JPH11158042A - Trichogen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a trichogen having an excellent trichogenous effect and having safety capable of sufficiently enduring its employment over a long period. SOLUTION: This trichogen contains an extract preferably in an amount of 0.001-10 wt.%. The extract is obtained by extracting Scrophularia buergeriana Miq. And/or Scrophularia ningpoensis Hemsl. preferably with a water-soluble organic solvent or a water-containing aqueous organic solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth / hair restoration material, and more particularly, to an object of the invention is to provide a hair growth / hair restoration material having excellent hair growth / hair restoration effects and having sufficient safety for long-term use. It is.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, as a crude drug extract, extracts such as yokuinin, ginkgo, cashew and the like (Japanese Patent Publication No. 1-13451)
And compounds such as vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ', 5'-cyclic monophosphate (see JP-A-64-56608). Gazette,
JP-A-1-261321, JP-A-2-20440
No. 6).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
There are drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, an extract obtained from a specific plant belonging to the family Scrophulariaceae has excellent hair growth and hair growth effects. In addition, they have found that there is no problem in safety during use, and have completed the present invention based on such findings.

[0006] That is, the present invention relates to sesame seeds and / or
Or hair growth and hair growth, characterized in that it contains an extract obtained by extracting from ginseng preferably with a water-soluble organic solvent or a water-containing water-soluble organic solvent in a range of 0.001 to 10% by weight. About charges.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, Scrophularia b (scientific name: Scrophularia b) applied to the present invention
uergeriana Miq.) and Ginseng (scientific name: Scrophularia ning)
poensis Hemsl.) is a perennial plant belonging to the family Scrophulariaceae distributed in Japan, Korea and China. Sesame clover or dried ginseng root is generally called ginseng in Chinese medicine, has vasodilatory and hypotensive effects, and has been used as an antipyretic and antithroat drug, but it has been used topically. From the point of view, it has never been used practically in cosmetics.
There is no example that directly examines the hair-growth effect at all, and it was found for the first time by the present inventors.

Next, in order to obtain the extract according to the present invention from the above-mentioned plants, a plant obtained by drying or pulverizing the plant body or a commercially available Chinese herb is extracted with an extraction solvent such as methanol, ethanol, propanol or butanol. Monohydric alcohols, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane, or the monohydric alcohols, polyhydric alcohols or acetone,
Extraction is carried out using a water-containing water-soluble organic solvent containing preferably at least 50% by weight of tetrahydrofuran, dioxane and the like, and further using a water-insoluble organic solvent such as hexane, heptane, cyclohexane and ethyl acetate. It is preferable to use a water-containing water-soluble organic solvent.

As a specific method, 100 g of a plant is used in an extraction solvent of 0.5 to 5 l at a temperature from room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, at heating for 4 to 8 hours, ~
Extract by digestion twice. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

Here, the content of the extract contained as an active ingredient of the hair growth and fostering agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 5% by weight.
% By weight. When the content is less than 0.001% by weight, the hair growth effect is reduced, and when the content exceeds 10% by weight, the stability is reduced.

Next, the hair growth and hair growth agent of the present invention has a more preferable hair growth and hair growth effect when it contains a skin peripheral vasodilator in addition to the above-mentioned extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, etc., and one or more of these. Is used.

[0013] The hair growth and fostering composition of the present invention includes, in addition to the above-mentioned extract and skin vasodilator, additives usually used for hair growth and fostering, such as hinokitiol, cationic surfactants and parabens. Fungicides, cooling agents such as l-menthol, hydrocarbons, waxes, fats and oils, esters,
Oils such as higher fatty acids and higher alcohols, and other surfactants, fragrances, pigments, antioxidants, ultraviolet protective agents, alcohols, pH adjusters, water, and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Here, a production example of an extract according to the present invention will be described. Production Example 1. 100 g of dried whole plant material of Gensan in 1 liter of ethanol
, Transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 2 Sesame seeds dried whole plant 10
0 g was immersed and extracted in 1 liter of 70% ethanol at room temperature for 10 days, the residue was separated by filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.9%)

Production Example 3 100 g of dried whole plant of Genseng is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.5%)

Production Example 4 Sesame seeds dried whole plant 10
0 g is immersed in 1 l of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.8%)

Production Example 5 Sesame seeds dried whole plant 10
0 g is immersed in 1 liter of an extraction solvent of propylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper,
The filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 6 100 g of dried whole plant of Genseng was immersed and extracted with 1 l of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (1.9% yield)

Next, a comparative test was conducted on the effect of the extract thus obtained on hair growth in mice.

"Mouse hair growth evaluation test" (1) Sample Invention product 1: 70% aqueous ethanol dispersion containing 5% ginseng extract (Production example 1) Invention product 2: Sesame plant extract (Production example) 70% aqueous ethanol dispersion containing 5% of 2) Invention product 3: 70% ethanol aqueous dispersion containing 5% of ginseng extract (Production Example 3) Invention product 4: Sesame plant extract (Production Example 4) Ingredient 5) in 70% Ethanol Aqueous Dispersion Product 5 of the Invention: A 70% Ethanol Aqueous Dispersion Containing 5% Sesame Extract (Preparation Example 5) Product 6: Ginseng Extract (Preparation Example 6) 70% aqueous ethanol dispersion containing 5% of water Comparative: 70% aqueous ethanol dispersion containing 1% of vitamin E Control: 70% aqueous ethanol

(2) Test method Eight groups were prepared using 9-week-old C3H mice, each group consisting of 10 mice, and their backs were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0024]

[Table 1]

As is evident from the results in Table 1, the extract of Sesame Scrophularis and the extract of Ginseng according to the present invention
It can be seen that the L value is greatly reduced and the blackness is increased as compared with the control and comparative vitamin E. This is presumed to be the result of the extract according to the present invention stimulating hair roots, increasing blood circulation around hair follicles, and activating metabolism.

[0026]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0027]

[Table 2]

"Human hair growth and hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 1 to 3 Comparative product: Sesame clover extract extract (Production Example 2) was removed from the hair tonic of Example 1. (Increase water) Hair tonic

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into four groups of five each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 3 shows the results.

[0030]

[Table 3]

As is evident from the results in Table 3, the hair growth and growth stimulant of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. Further, at the end of the test, three persons in Example 1 and one person in Example 2 reported that the condition of the scalp was improved and the occurrence of dandruff was reduced. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Embodiment 4 Hair tonic (A) Sesame plant extract (Preparation example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Embodiment 5 Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10 cs) 2.0 Cetanol 4.0 Sesame plant extract (Preparation example 5) 4.5 (B) Stearyl trimethyl ammonium chloride 3.0 Distearyl dimethyl ammonium chloride 0.5 Propylene glycol 5.0 Pyroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Embodiment 6 Hair shampoo (A) triethanolamine lauryl sulfate 10.0 sodium lauryl sulfate 5.0 coconut oil diethanolamide 2.0 propylene glycol 5.0 pyrocton olamine 0.25 benzyl nicotinate 0.1 ginseng extract (Production Example 3) 1.0 (B) trichlorocarbanilide 0.25 Purified water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Embodiment 7 Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 Ginseng extract (Production Example 1) 2.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C) Glycyrrhizin dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And mixed at that point. Thereafter, the mixture was cooled to around 40 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 8 FIG. Hair cream (A) Sesame clover extract (Production Example 2) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B) preliminarily heated to 80 ° C. was gradually added to (A) and emulsified. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

Embodiment 9 Hair tonic (A) Ginseng extract (Preparation Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in the above Examples 4 to 9 were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or according to the same method. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0045]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hideo Kuroda 560 Pola, Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Inside the Totsuka Research Laboratories Co., Ltd. Industrial Co., Ltd.

Claims (4)

[Claims] 1. A hair-growing / hair-growing agent comprising an extract of sesame seeds and / or ginseng. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
The hair growth and fostering material according to any one of claims 1 and 2, which is in terms of% by weight. 4. The hair growth and fostering composition according to claim 1, wherein the hair growth and fostering composition contains a skin peripheral vasodilator.