JPH09241136A - Hair growing and restoring agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new hair growing and restoring agent having an excellent hair-growing effect and a stability capable of sufficiently tolerating in using for a long period of time by using an extract obtained from a specific plant belonging to the family Labiatae. SOLUTION: This agent is an extract obtained by extracting deucas cephalotes of a vegetation belonging to the genus deucas, family dabiatae originally growing and distributing at lowlands in a Nepal area with a water-soluble organic solvent or water-soluble organic solvent containing water. The amount of the extract containing in this hair grower is 0.001-10wt.%, particularly 0.05-5wt.%. It is preferable to include a vasodilator for peripheral blood vessel of skin in the hair grower. As the vasodilator for peripheral blood vessel of skin, e.g. carpronium chloride, benzeyl nicotinate, vitamin E, vitamin E acetate, etc. are illustrated. This hair grower is possible to prepare in dosage forms such as e.g. hair tonic, shampoo, rinse, pomade, hair lotion, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth / hair restoration material, and more particularly, to provide a hair growth / hair restoration material having excellent hair growth / hair growth effects and having sufficient safety to withstand long-term use. Is what you do.

[0002]

2. Description of the Related Art Conventionally provided hair growth and hair growth products contain various crude drug extracts or various compounds. For example, crude drug extracts include extracts such as yoquinin and cashew (see Japanese Patent Publication No. 1-13451, JP-A-2-48514, etc.), and compounds such as vitamin E, alloxazine, pyridine N-oxide and adenosine-3. ', 5'-cyclic monophosphate (JP-A-64-56608,
1-261321, JP-A-2-204406, etc.).

[0003]

However, the hair growth and hair growth materials provided so far include, as mentioned in the above examples,
Various crude drug extracts and various compounds have been applied, but few have a remarkable effect, and those having a certain effect are so stimulating that dermatitis is caused,
It has drawbacks such as difficulty in continuous use.

[0004] The present invention has been made in view of such circumstances, and provides a hair growth and fostering material that is excellent in hair growth and fostering effects and has sufficient safety to withstand long-term use. That is the task.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to solve the above problems, and as a result, an extract obtained from a specific plant belonging to the Labiatae family exhibits excellent hair growth and hair growth effects. The present invention has been found to have no safety problem during use, and the present invention has been completed based on such findings.

That is, the present invention is preferably an extract obtained by extracting from Leucus kephalothes with a water-soluble organic solvent or a water-containing water-soluble organic solvent, preferably 0.0
The present invention relates to a hair-growth / hair-growth material which is contained in the range of 01 to 10% by weight.

[0007] The present invention also relates to a hair growth and fostering material further comprising a skin peripheral vasodilator in the above hair growth and fostering material.

Hereinafter, the present invention will be described in detail. First, Leucus kephalothes (scientific name: Leuc) applied to the present invention
as cephalotes) is a herb belonging to the genus Yambaruhakka genus, which is natively distributed in the lowlands of the Nepal region, and is called another name in the Nepalese called Gunmpati. Up to now, it has been known that Leucus kephalotes is used as a stimulant, a sweating agent, an insecticide or its leaf juice as an external medicine for scabies, etc. -No example of verifying the hair-growth effect was found, and it was first discovered by the present inventor.

Next, in order to obtain the extract of the present invention from the above Leucus kephalothes, the plant is dried or ground as it is, and the extract solvent is used, for example, a monohydric alcohol such as methanol, ethanol, propanol or butanol, Polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane; or the above monohydric alcohols, polyhydric alcohols or acetone,
Extraction is carried out using a water-containing water-soluble organic solvent containing preferably 50% by weight or more of tetrahydrofuran, dioxane or the like, and a non-water-soluble organic solvent such as hexane, heptane, cyclohexane or ethyl acetate, preferably a water-soluble organic solvent or It is preferable to use a water-containing water-soluble organic solvent.

As a specific method, 100 g of Leucus kephalothes was used with 0.5 to 5 l of an extraction solvent at room temperature to
At the temperature of the boiling point of the extraction solvent, digestion extraction is performed once or twice at room temperature for 7 to 10 days and at heating for 4 to 8 hours. These extracts were combined, suction filtered, and concentrated under reduced pressure to remove the solvent,
A viscous or dry extract is obtained. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the hair growth and hair growth material of the present invention.

The content of the extract of Leucus kephalothes extract contained as an active ingredient of the hair-growth and hair-growth agent according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.05 to 5% by weight. Is. Content is 0.00
If it is less than 1% by weight, the hair-growth effect is lowered, and if it exceeds 10% by weight, the stability is lowered.

Next, the hair-growth / hair-growth composition of the present invention has a more preferable hair-growth / hair-growth effect when it contains a skin peripheral vasodilator in addition to the above-mentioned Leucus kephalothes extract. Such skin peripheral vasodilators include, for example, carpronium chloride, benzyl nicotinate,
Examples thereof include vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, capsicum tincture, and one or more of these are used.

Further, the hair growth and hair growth composition of the present invention includes the above-mentioned Leucus kephalothes extract, skin peripheral vasodilator, and other additives commonly used in hair growth and hair growth compositions, such as hinokitiol and cationic surfactants. , Bactericides such as parabens, cooling agents such as l-menthol, hydrocarbons, waxes, oils and fats, esters, higher fatty acids, oils such as higher alcohols, other surfactants, fragrances, pigments, antioxidants,
An ultraviolet protective agent, alcohols, a pH adjusting agent, water and the like can be added.

The hair growth and hair growth agent of the present invention includes various dosage forms, for example, hair tonic, shampoo, rinse, pomade, hair lotion, hair cream, hair treatment and the like, and is prepared according to a conventional method.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of the Leucus kephalothes extract according to the present invention will be shown. Production Example 1. 100 dried whole plants of Leucus kephalothes
g was immersed in 1 liter of 70% ethanol at room temperature for 10 days for extraction, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.1%)

Production Example 2 100 g of dried whole grass of Leucus kephalothes is immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and extracted by heating for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 3.2%)

Production Example 3 100 g of dried whole grass of Leucus kephalothes is immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 4 100 g of a dried whole plant of Leucus kephalothes is immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.2%)

Production Example 5 100 g of dried whole grass of Leucus kephalothes was added to propylene glycol: distilled water = 1:
It is immersed in 1 liter of extraction solvent 1 and transferred to a Soxhlet extractor, and hot extraction is performed for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.8%)

Production Example 6 100 g of a dried whole plant of Leucus kephalothes was immersed and extracted with 1 liter of ethyl acetate at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extracted extract. (Yield 1.5%)

Next, the Leucus
A test was carried out for the effect of Kefalotes extract on hair growth in mice.

"Mouse Hair Growth Evaluation Test" (1) Sample This invention: 70% ethanol aqueous dispersion containing 5% Leucus kephalothes extract (Production Example 2) Comparative product: 1% vitamin E 70% ethanol aqueous dispersion control: 70% ethanol aqueous solution

(2) Test method Using 9-week-old C3H mice, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 16th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 1 shows the results.

[0024]

[Table 1]

As is clear from the results shown in Table 1, in the Leucus kephalothes extract according to the present invention, the L value is decreased and the blackness is increased as compared with the control. On the other hand, the vitamin E of the comparative product showed almost no decrease in the L value as compared with the control. It is speculated that this is because the Leucus kephalothes extract according to the present invention stimulated the hair roots, increased blood circulation around the hair follicles, and activated metabolism.

[0026]

The present invention will be further described with reference to the following examples.
In addition, the compounding amount is a weight part. Embodiments 1-3. Hair tonic Using the components and composition shown in Table 2 below, each component was heated and dissolved, and solubilized to prepare a hair tonic.

[0027]

[Table 2]

"Human Hair Growth / Hair Growth Evaluation Test" (1) Sample Product of the present invention: Hair tonic of Examples 1 to 3 Comparative product: Leucus kephalothes extract (Production Example 2) from hair tonic of Example 1 Removed (increased water)
Hair tonic

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into four groups of five each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to report their scalp condition and reduce dandruff. Table 3 shows the results.

[0030]

[Table 3]

As is evident from the results in Table 3, the hair growth and growth stimulant of the present invention has a hair growth effect because the number of people who have developed alveoli and those who have hard hair have increased. Was done. At the end of the test, the number of persons who reported improvement in the condition of the scalp and reduced occurrence of dandruff were 4 in Example 1 and 3 in Example 2. From this, the hair growth / hair growth material of the present invention was also confirmed to have a hair growth effect. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

Example 4. Hair Tonic (A) Leucus kephalothes extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Hydrochloric acid Diphenhydramine 0.3 Methylparaben 0.2 (D) Purified water 39.75 (E) Perfume 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

Example 5. Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10cs) 2.0 Cetanol 4.0 Leucus kephalotes extract (Production Example 5) 4.5 (B) Stearyltrimethylammonium chloride 3.0 Distearyldimethylammonium chloride 0.5 Propylene glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing them. Thereafter, the mixture was cooled to around 40 ° C., at which point (C) was added, and further (D) was added to prepare a hair treatment.

Example 6. Hair shampoo (A) lauryl sulfate triethanolamine 10.0 Sodium lauryl sulfate 5.0 Coconut oil diethanolamide 2.0 Propylene glycol 5.0 Piroctone olamine 0.25 Benzyl nicotinate 0.1 Leucus kephalotes extract (Production Example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.3 (C) Perfume 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.

Example 7. Hair rinse (A) Liquid paraffin 0.5 Methyl polysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyl trimethyl ammonium chloride 3.0 Leucus kephalotes extract (Production example 2) 2.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C ) Glycyrrhizin dipotassium 0.25 Purified water 46.4 (D) Perfume 0.1

(Preparation method) (A) and (B) were each heated to 80 ° C.
And emulsify by mixing at that point. Then 40 ° C
After cooling to near, (C) was added, and (D) was further added to prepare a hair rinse.

Example 8. Hair Cream (A) Leucus kephalothes extract (Production Example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) Cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E Nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 (C) Perfume 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C., and then (B), which had been heated to 80 ° C. in advance, was gradually added to (A) to form a cream. Thereafter, the mixture was cooled to 40 ° C., and (C) was added to prepare a hair cream.

Example 9. Hair Tonic (A) Leucus kephalothes extract (Production Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Capsicum tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Perfume 0.1

(Preparation method) (A) was dissolved in (B), and (D) and (E), in which (C) was dissolved, were added thereto to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in the above Examples 4 to 9 were tested for hair growth and hair growth effects by the same method as in Examples 1 to 3 or according to the same method. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0045]

According to the present invention, it is possible to provide a hair-growth / hair-growing agent which has an excellent hair-growth / hair-growth effect and which is free from skin disorders due to long-term continuous use and which is excellent in safety.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 45/00 ABR A61K 45/00 ABR // (A61K 35/78 45:00)

Claims (4)

[Claims] 1. A hair-growth / hair-growth material containing an extract of Leucus kephalothes. 2. The hair growth and fostering composition according to claim 1, wherein the extract is extracted with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
3% by weight.
Hair restoration. 4. The hair growth and fostering composition according to claim 1, wherein the hair growth and fostering composition contains a skin peripheral vasodilator.