JP3744758B2 - Cosmetics - Google Patents

Description

【００２６】
【表２】

【００２７】
表１、表２の結果に示されるように、本発明品の化粧水は比較品の化粧水に比べ乾燥感の改善、肌あれ改善が顕著であり、美肌効果に優れていることが実証された。
尚、上記評価要素以外の意見として、本発明の化粧料は使用時における刺激感、皮膚の炎症などの安全性面での弊害はないことも同時に明らかとなった。
【００２８】
２．発毛・育毛効果試験
「マウス毛成長評価試験」
（１）試料
本発明品 ：プラタヌス・メキシカーナ抽出物（製造例２）を５％含有する７０％エタノール水分散液
比較品 ：ビタミンＥを１％含有する７０％エタノール水分散液
コントロール：７０％エタノール水溶液
【００２９】
（２）試験方法
９週令のＣ３Ｈマウスを用い、１群を１０匹とし、３群作り、これらの背部を２.０×２.０ｃｍの広さに除毛した後、翌日除毛部位に各試料を０．０４ｇ塗布した後、２０日目に当該部位の毛成長の密度を色差計を用いて黒色増加度として評価した。その結果を表３に示す。
【００３０】
【表３】

【００３１】
表３の結果から明らかなように、本発明に係るプラタヌス・メキシカーナ抽出物では、コントロールと比較してＬ値が減少し、黒色度が増加していることが分かる。一方、比較品のビタミンＥでは本発明品と比較してコントロールに対するＬ値の減少が少ししか認められなかった。これは本発明に係るプラタヌス・メキシカーナ抽出物が毛根を刺激、毛包周囲の血行をより盛んにし、代謝を活発にした結果と推察される。
【００３２】
「ヒト発毛・育毛評価試験」
（１）試料
本発明品：後記実施例７〜９のヘアトニック
比較品 ：後記実施例７のヘアトニックからプラタヌス・メキシカーナ抽出物（製造例２）を除いた（水を増量）ヘアトニック
【００３３】
（２）試験方法
薄毛症、脱毛症を訴える２０名のパネラーを各５名ずつ４群に分け、各試料を用いて６ヶ月間の長期連用試験を実施した。適用方法は通常のトニック使用法と同様一日２回、頭部にまんべんなく塗布する方法を用いた。また評価は使用開始後３ケ月目と６ケ月目に行ない、うぶ毛、硬毛が増えてきたと感じた被験者がどの程度増えたかを計測した。更に、テスト終了時に頭皮の状態の改善や、ふけの発生の減少についても申告してもらった。その結果を表４に示す。
【００３４】
【表４】

【００３５】
表４の結果から明らかなように、本発明の発毛・育毛料は、何れもうぶ毛を生じた人、硬毛を生じた人が増加していることから発毛・育毛効果が認められた。また、テスト終了時に頭皮の状態が改善され、ふけの発生の減少を申告した人が、実施例７では３名、実施例８では２名数えられた。このことから本発明の発毛・育毛料には頭皮の状態を改善する効果も認められた。更に、使用テスト期間中に何れのパネラーにも頭皮の状態の悪化、炎症性の反応等の皮膚障害は全く観察されなかったことから、安全性も高いことが確認された。
【００３６】
【実施例】
以下に、本発明の実施例を示す。尚、配合割合は重量部である。
【００３７】

【００３８】
（調製方法）
（Ａ）の各成分を合わせ、室温下に溶解する。一方、（Ｂ）の各成分も室温下に溶解し、これを（Ａ）処方分に加えて可溶化する。
【００３９】

【００４０】
（調製方法）
（Ａ）の各成分に合わせ、加熱混合し、７０℃とする。（Ｂ）の各成分を合わせ、７０℃に加熱混合し、これに（Ａ）処方分を加え乳化し、冷却しながら（Ｃ）を加える。
【００４１】

【００４２】
（調製方法）
実施例２と同様の方法による。
【００４３】

【００４４】
（調製方法）
（Ａ）の各成分を合わせ、８０℃に加熱する。（Ｂ）の各成分を合わせ、８０℃に加熱する。（Ａ）の処方分を攪はんしながら、それに（Ｂ）の処方分を加え攪はん乳化し、その後冷却する。
【００４５】

【００４６】
（調製方法）
（Ａ）を室温にて分散溶解する。これに（Ｂ）を加えて均一に溶解する。
【００４７】

【００４８】
（調製方法）
（Ｂ）の各成分を合わせ、７０〜８０℃に加熱し、これに（Ａ）を溶解する。これに、（Ｃ）の処方分を加え、冷却して４０℃になったら（Ｄ）を添加し、次いで冷却する。
【００４９】
実施例７〜９．ヘアトニック
下記表５に示す成分及び配合組成を用い、各成分を加温溶解し、可溶化してヘアトニックを調製した。
【００５０】
【表５】

【００５１】

【００５２】
（製法）
（Ｂ）に（Ａ）を溶かしておき、これに（Ｃ）を溶解した（Ｄ）及び（Ｅ）を加えてヘアトニックを調製した。
【００５３】

【００５４】
（製法）
（Ａ）および（Ｂ）をそれぞれ８０℃に加温し、両者を混合して乳化する。その後４０℃付近まで冷却し、その時点で（Ｃ）を添加し、更に（Ｄ）を添加しヘアトリートメントを調製した。
【００５５】

【００５６】
（製法）
（Ａ）を８０℃にて混合し、その後４０℃付近まで冷却して（Ｂ）を添加し、更に（Ｃ）を添加しヘアシャンプーを調製した。
【００５７】

【００５８】
（製法）
（Ａ）及び（Ｂ）をそれぞれ８０℃に加温し、その時点で混合して乳化する。その後 ４０℃付近まで冷却し、（Ｃ）を添加し更に（Ｄ）を添加しヘアリンスを調製した。
【００５９】

【００６０】
（製法）
（Ａ）を８０℃にて混合溶解し、次に予め８０℃に加熱しておいた（Ｂ）を（Ａ）に徐々に加えクリーム状とした。その後４０℃まで冷却し、（Ｃ）を添加してヘアクリームを調製した。
【００６１】

【００６２】
（製法)
（Ｂ）に（Ａ）を溶かしておき、これに（Ｃ）を溶解した（Ｄ）及び（Ｅ）を加えてヘアトニックを調製した。
【００６３】
上記実施例１０〜１５で得られた本発明の発毛・育毛料について、実施例７〜９と同様の又は準じる方法で発毛・育毛効果の検定を行ったところ、何れも優れた効果を示し、また頭皮の状態の悪化、炎症性の反応等の皮膚障害は全く観察されなかった。
【００６４】
【発明の効果】
本発明によれば、従来から知られている肌あれ改善剤などに比べて、肌あれ等の皮膚状態の改善などの美肌効果が格段に優れていることは勿論のこと、優れた発毛・育毛効果を有し、長期連用による皮膚障害等も認められず安全性面の弊害もない化粧料を使用することができる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to cosmetics, and in particular, it has excellent skin beautifying effects by improving dryness, rough skin, etc. on the skin, while it has excellent hair growth and hair growth effects such as hair growth and hair growth promotion for hair. The fee is not provided.
[0002]
[Prior art]
Conventionally, various herbal extracts have been blended in cosmetics. For example, in the case of skin cosmetics, for the purpose of preventing rough skin and improving wrinkles, extract extracts such as placenta extract, Yokuinin, Ogon, Bukkuri (Japanese Patent Laid-Open Nos. 57-31604 and 59-73509) Extracts such as Yokuinin and Kashu for hair growth effect (see Japanese Patent Publication No. 1-13451, Japanese Patent Laid-Open No. 2-48514, etc.) Etc.) are blended.
[0003]
[Problems to be solved by the invention]
However, as shown in the above examples, various herbal extracts have been applied to the cosmetics provided so far, but there are almost no significant effects, and there are some effects. There were drawbacks such as strong irritation that caused dermatitis and difficulty in continuous use.
[0004]
The present invention has been made in view of such a situation, and has excellent skin beautifying effects by improving dry feeling, rough skin, etc. on the skin, while hair growth, hair growth promotion, etc. on the hair. It is an object of the present invention to provide a cosmetic material that has excellent hair growth and hair growth effects and has safety sufficient to withstand long-term use.
[0005]
[Means for Solving the Problems]
As a result of intensive research to solve the above problems, the present inventor has an excellent skin-beautifying effect on the skin of an extract obtained from a specific plant belonging to the family Papaveraceae, while being excellent for hair. The present invention has been found to have a hair growth / hair growth effect and has no safety problems during use, and the present invention has been completed based on such findings.
[0006]
That is, the present invention is preferably 0.001 to 10% by weight of an extract obtained by extraction from a plant of Platanus Mexicana, preferably with a water-soluble organic solvent or a water-containing water-soluble organic solvent. It is related with the cosmetics characterized by containing in the range. The present invention also relates to a cosmetic that preferably further contains a peripheral blood flow promoter. The cosmetic of the present invention is suitable as a hair growth / hair growth material.
[0007]
Hereinafter, the present invention will be described in detail.
[0008]
First, Platanus Mexicana applied to the present invention is a large deciduous tree belonging to the genus Platanus, which is distributed mainly from North America to Mexico. Until now, it was known that Platanus mexicana was used as a roadside tree or a row of trees, but it was not practically applied from an external point of view. It was discovered for the first time by this inventor about having an effect.
[0009]
The above plant of Platanus mexicana contains ingredients that activate the original functions of the skin, so when Platanus mexicana extract is added to cosmetics, it has excellent skin beautifying effects and hair growth / hair growth effects. The cosmetics to play can be obtained. In addition, the said beautiful skin means that the skin in bad states, such as dry skin and rough skin, is improved so that it can confirm from an external appearance. In addition, the above-mentioned hair growth / growth refers to making the hair grow, for example, hair growth for newly growing hair, growing the growing hair, or maintaining the hair growing state. It is a concept that includes hair growth and the like, and it is sufficient that at least one of the above-described hair growth and hair growth is exhibited.
[0010]
Next, in order to obtain the extract according to the present invention from the above-mentioned Platanus mexicana, each part of the plant body which is the whole tissue constituting the plant or a part thereof, preferably a leaf or a bark is dried or ground as it is. Extracted solvents such as monohydric alcohols such as methanol, ethanol, propanol and butanol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, or water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane, or the above-mentioned Extraction with monohydric alcohol, polyhydric alcohol or water-containing water-soluble organic solvent preferably containing 50% by weight or more of acetone, tetrahydrofuran, dioxane, etc., and water-insoluble organic solvents such as hexane, heptane, cyclohexane, ethyl acetate However, preferably a water-soluble organic solvent or Good to use a water-soluble organic solvent.
[0011]
As a specific method for obtaining a cosmetic according to the present invention, for example, 100 g of Platanus mexicana is used with an extraction solvent of 0.5 to 5 L, at a temperature from room temperature to the boiling point of the extraction solvent, and at room temperature for 4 to 10 days. Digestion is performed once or twice for 4 to 8 hours during warming. These extracts are combined, filtered with suction, and concentrated under reduced pressure to remove the solvent to obtain a viscous or dry extract. The obtained extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and blended in a base to obtain the cosmetic of the present invention.
[0012]
Here, the content of the Platanus mexicana extract according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.01 to 5% by weight, based on the entire cosmetic. When the content is less than 0.001% by weight, the intended effect of the present invention is not sufficiently exhibited, and when the content exceeds 10% by weight, the stability of the cosmetic may be lowered depending on the dosage form.
[0013]
Next, when the cosmetic composition of the present invention is used as a hair growth / hair growth material, it can have a more preferable hair growth / hair growth effect by adding a peripheral blood flow promoter in addition to the above-mentioned Platanus mexicana extract. The peripheral blood flow promoter may be a substance that has the effect of promoting blood flow in the peripheral blood vessels by expanding the blood vessel wall, and suppresses the generation of lipids that worsen the blood flow in the peripheral blood vessels. By doing so, a substance that reinforces the blood vessel wall and restores the original vasomotor function may be used. Examples of such peripheral vascular blood flow promoters include carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, capsicum tincture, etc., one or two of these The above is used.
[0014]
In addition to the above-mentioned Platanus mexicana extract and peripheral vascular blood flow promoter, the cosmetics of the present invention include various components used in normal skin cosmetics and hair growth / hair growth agents, if necessary. Additives such as inorganic pigments, organic pigments, inorganic powders, organic powders, hydrocarbons, waxes, fats and oils, esters, higher fatty acids, higher alcohols, triglycerides, lanolins, waxes, animal and vegetable oils , Silicones, surfactants, polyhydric alcohols, sugars, vitamins, amino acids, refreshing agents, antioxidants, antiseptics / disinfectants, fragrances, thickeners, UV protection agents, alcohols, pH adjusters And water etc. can be mix | blended.
[0015]
Examples of the cosmetics of the present invention include various dosage forms. Examples of skin cosmetics include skin lotions, emulsions, creams, packs, foundations, and lipsticks, and examples of hair growth / hair growth materials include hair tonics and shampoos. , Rinse, pomade, hair lotion, hair cream, hair treatment and the like, and are prepared according to conventional methods.
[0016]
DETAILED DESCRIPTION OF THE INVENTION
Here, the manufacture example of the Platanus mexicana extract which concerns on this invention is shown.
Production Example 1
100 g of dried bark of Platanus mexicana was extracted by immersion in 2 L of methanol at room temperature for 4 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.1%)
[0017]
Production Example 2
100 g of dried bark of Platanus mexicana was extracted by immersion in 2 L of 70% ethanol at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.9%)
[0018]
Production Example 3
100 g of dried Platanus mexicana leaves are immersed in 2 L of acetone, transferred to a Soxhlet extractor, and warmed extraction is performed for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.2%)
[0019]
Production Example 4
100 g of dried Platanus mexicana leaves are immersed in 2 L of butanol, transferred to a Soxhlet extractor, and warmed extraction is performed for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.8%)
[0020]
Production Example 5
100 g of dried bark of Platanus mexicana is dipped in 2 L of an extraction solvent of propylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and heated extraction is performed for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.3%)
[0021]
Production Example 6
100 g of dried Platanus mexicana leaves were immersed and extracted with 2 L of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.7%)
[0022]
Next, the results of tests conducted to demonstrate how the cosmetics of the present invention are superior in terms of skin beautifying effects and hair growth / hair growth effects are shown.
[0023]
1. Skin care effect test (1) Sample product of the present invention: skin lotion comparison product of Example 1 described later 1: skin lotion comparison product 2 prepared by replacing Platanus mexicana extract in the skin lotion of Example 1 below with placenta extract: Skin lotion from which Platanus mexicana extract was removed from the skin lotion of Example 1 described later (water increased)
(2) Test method Forty-five Japanese adult women with dry skin were randomly divided into 3 groups (A to C groups) of 15 each. The skin lotion of the present invention was applied to the face of Group A, the skin lotion of Comparative Product 1 was applied to the face of Group B, and the skin lotion of Comparative Product 2 was applied to the face of Group C for 4 weeks. Comparison was made between groups regarding the state of improvement in dry feeling after 4 weeks and the state of natural exacerbation (the state in which skin drying progressed despite the application of the above-described lotion). For evaluation of skin roughness, the stratum corneum was isolated from the facial skin by a tape stripping method, and according to the method described in Japanese Patent Laid-Open No. 63-113358, the degree of delamination and presence were confirmed by optical microscope observation of the stratum corneum. The presence or absence of nuclear cells was evaluated on a five-point scale. The results are shown in Tables 1 and 2.
[0025]
[Table 1]

[0026]
[Table 2]

[0027]
As shown in the results of Tables 1 and 2, the skin lotion of the present invention has a significant improvement in dry feeling and rough skin compared to the skin lotion of the comparative product, and it has been demonstrated that it has an excellent skin beautifying effect. It was.
As an opinion other than the above evaluation factors, it was also clarified at the same time that the cosmetic of the present invention has no adverse effects on safety such as irritation during use and skin irritation.
[0028]
2. Hair growth and hair growth effect test "Mouse hair growth evaluation test"
(1) Sample product of the present invention: 70% ethanol aqueous dispersion containing 5% Platanus mexicana extract (Production Example 2): 70% ethanol aqueous dispersion containing 1% vitamin E Control: 70% ethanol Aqueous solution 【0029】
(2) Test method Using 9-week-old C3H mice, one group consists of 10 mice, and 3 groups are made. After these hairs are removed to a size of 2.0 × 2.0 cm, the next day, the hair removal site is applied. After applying 0.04 g of each sample, on the 20th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. The results are shown in Table 3.
[0030]
[Table 3]

[0031]
As is clear from the results in Table 3, it can be seen that in the Platanus mexicana extract according to the present invention, the L value decreased and the blackness increased compared to the control. On the other hand, in the comparative product Vitamin E, there was little decrease in the L value relative to the control compared to the product of the present invention. This is presumed to be a result of the Platanus mexicana extract according to the present invention stimulating the hair roots, making blood circulation around the hair follicle more active, and activating metabolism.
[0032]
"Human hair growth and hair growth evaluation test"
(1) Sample product of the present invention: Comparative hair tonic of Examples 7 to 9 described later: Hair tonic obtained by removing Platanus mexicana extract (Production Example 2) from the hair tonic of Example 7 described later (increasing water) ]
(2) Test method 20 panelists complaining of hirsutism and alopecia were divided into 4 groups of 5 each, and a 6-month long-term continuous test was conducted using each sample. The application method used was a method of evenly applying to the head twice a day in the same manner as in the normal tonic method. The evaluation was performed in the third and sixth months after the start of use, and the degree of increase in the number of subjects who felt that vellus hair and bristles increased was measured. In addition, at the end of the test, I was told to improve my scalp condition and reduce the occurrence of dandruff. The results are shown in Table 4.
[0034]
[Table 4]

[0035]
As is apparent from the results of Table 4, the hair growth / hair growth material of the present invention has a hair growth / hair growth effect due to the increase in the number of people who have grown hair and those who have hard hair. It was. In addition, 3 people in Example 7 and 2 people in Example 8 reported that the condition of the scalp was improved at the end of the test and the decrease in the occurrence of dandruff was reported. From this, the hair growth / hair growth material of the present invention was also recognized to have an effect of improving the condition of the scalp. Furthermore, since no skin damage such as deterioration of the scalp and inflammatory reaction was observed in any of the panelists during the use test period, it was confirmed that the safety was high.
[0036]
【Example】
Examples of the present invention are shown below. In addition, a mixture ratio is a weight part.
[0037]

[0038]
(Preparation method)
The components (A) are combined and dissolved at room temperature. On the other hand, each component of (B) also melt | dissolves at room temperature, and this is added and solubilized in (A) prescription part.
[0039]

[0040]
(Preparation method)
According to each component of (A), it heat-mixes and makes it 70 degreeC. (B) Each component is match | combined, it heat-mixes at 70 degreeC, (A) prescription part is added and emulsified to this, and (C) is added, cooling.
[0041]

[0042]
(Preparation method)
By the same method as in Example 2.
[0043]

[0044]
(Preparation method)
The components (A) are combined and heated to 80 ° C. Combine each component of (B) and heat to 80 ° C. While stirring the prescription of (A), the prescription of (B) is added to it and stirred to emulsify, and then cooled.
[0045]

[0046]
(Preparation method)
Disperse and dissolve (A) at room temperature. (B) is added to this and it melt | dissolves uniformly.
[0047]

[0048]
(Preparation method)
The components (B) are combined and heated to 70 to 80 ° C., and (A) is dissolved therein. To this, the formulation of (C) is added, and when cooled to 40 ° C., (D) is added and then cooled.
[0049]
Examples 7-9. Hair tonic Using the components and composition shown in Table 5 below, each component was dissolved by heating and solubilized to prepare a hair tonic.
[0050]
[Table 5]

[0051]

[0052]
(Manufacturing method)
A hair tonic was prepared by dissolving (A) in (B) and adding (D) and (E) in which (C) was dissolved.
[0053]

[0054]
(Manufacturing method)
Each of (A) and (B) is heated to 80 ° C., and both are mixed and emulsified. Thereafter, it was cooled to around 40 ° C., at which point (C) was added, and (D) was further added to prepare a hair treatment.
[0055]

[0056]
(Manufacturing method)
(A) was mixed at 80 ° C., then cooled to around 40 ° C., (B) was added, and (C) was further added to prepare a hair shampoo.
[0057]

[0058]
(Manufacturing method)
(A) and (B) are each heated to 80 ° C. and mixed and emulsified at that time. Thereafter, it was cooled to around 40 ° C., (C) was added, and (D) was further added to prepare a hair rinse.
[0059]

[0060]
(Manufacturing method)
(A) was mixed and dissolved at 80 ° C, and then (B), which had been heated to 80 ° C in advance, was gradually added to (A) to form a cream. Thereafter, it was cooled to 40 ° C. and (C) was added to prepare a hair cream.
[0061]

[0062]
(Manufacturing method)
A hair tonic was prepared by dissolving (A) in (B) and adding (D) and (E) in which (C) was dissolved.
[0063]
When the hair growth / hair growth material of the present invention obtained in Examples 10-15 above was tested for hair growth / hair growth effect in the same or similar manner as in Examples 7-9, all had excellent effects. No skin disorders such as worsening of the scalp condition and inflammatory reaction were observed.
[0064]
【The invention's effect】
According to the present invention, compared with conventionally known skin roughness improving agents and the like, not only the skin beautification effect such as improvement of skin condition such as skin roughness is remarkably superior, but also excellent hair growth / Cosmetics that have a hair-growth effect, do not cause skin damage or the like due to long-term continuous use, and have no adverse effects on safety can be used.

Claims (5)

A cosmetic comprising an extract of a plant of Platanus Mexicana. The cosmetic according to claim 1, wherein the extract is extracted from the plant with a water-soluble organic solvent or a water-containing water-soluble organic solvent. The cosmetic according to claim 1, wherein the content of the extract is 0.001 to 10% by weight. The cosmetic according to any one of claims 1 to 3, wherein the cosmetic is a hair growth / hair growth material. Furthermore, the cosmetics of Claim 4 containing a peripheral vascular blood flow promoter.