JPS6168408A - Hair tonic - Google Patents

Abstract

PURPOSE:A hair tonic that contains an extract obtained from Prunus africana barks and, preferably a dermovasodilator such as capronium chloride or benzyl nicotinate, thus having hair tonic effect with high safety. CONSTITUTION:Barks of Prunus africana are dried, extracted with chloroform and the resultant essence is combined with a dermoperipheral vasodilator such as capronium chloride or benzyl nicotinate, vitamin E acetate, vitamin E linolate or vitamin E nicotinate to give the objective hair tonic. This hair tonic has good acceleration effect on hair growth and shows action to inhibit dandruff, hair falling without undesirable side-effect by hormones. The essence of Prunus africana is added by 0.001-5wt% and added as such or in the form of a solution in, e.g., alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION "Object of the Invention" The present invention is directed to Prunus africana.
The present invention relates to a hair nourishing agent that is highly safe and has an excellent hair nourishing effect, which contains an extract obtained from the bark of Prunus africana (hereinafter referred to as Prunus or Africana extract).

"Prior Art" Conventionally, hair nourishing products have been made by adding substances that have a hair growth promoting effect or a hair nourishing effect to a lotion type base and applying this to the scalp. Many substances have been proposed to have this effect of promoting hair growth or nourishing hair, including hormonal agents and 5α-reductase inhibitors, but some of them have undesirable side effects such as hormonal effects, or are not actually effective. It had drawbacks such as weak hair-growth effect when applied to the scalp. In addition, skin peripheral vasodilators such as vitamin E nicotinate, which have been used since ancient times, were insufficient in terms of hair-growth effects.As mentioned above, many of the products currently used as hair-growth agents are However, there are some drawbacks, and the development of a new hair nourishing agent is desired.

[Improvements made by the present inventors] Therefore, the present inventors first examined the bald area of a male-type bald head using an MZ surface microscope (X25) manufactured by eitZ Co., Ltd.
Upon closer observation, it was observed that there was no hair at all in the area, but rather a sparse growth of downy hair. In other words, androgenetic alopecia is a result of the terminal hair becoming thinner and shorter each time it grows through the hair cycle, becoming electrified, and is caused by the weakening of the hair matrix cells and hair follicles at the hair root due to some reason. considered to be a thing. Furthermore, the present inventors biopsied the skin of this patient with androgenetic alopecia and observed histologically.

As a result, no particular abnormality was observed in the epidermis or dermis, but the hair roots were atrophied and became seed-rod-shaped, and the sebaceous glands were found to be abnormally developed and enlarged. In other words,
Abnormal development of the sebaceous glands, which is not seen in normal terminal conditions, was observed. As a result of similar investigation and examination of a large number of patients with androgenetic alopecia, it was found that the development of sebaceous glands in the scalp at the site of hair loss was more pronounced than in normal scalp, and the activity of sebaceous gland cells and hair matrix cells was significantly lower. It turned out to be a contradictory relationship.

Based on the above findings, the present inventors have discovered that the development of sebaceous glands,
In particular, we have searched for a substance that suppresses the proliferation of sebaceous glands enlarged by Testosterone, is harmless to the human body, and has no side effects, and have conducted extensive research in order to develop a hair nourishing agent with excellent hair nourishing effects by incorporating this substance. As a result, it was discovered that Prunus africana extract achieves the above object, and based on this finding, the present invention was completed.

That is, the present invention provides a hair nourishment containing Prunus and Africana extracts.

(The following is a blank space) "Configuration of the present invention" The configuration of the present invention will be described in detail below. The Prunus africana extract used in the present invention is a tree native to the Natal region of South Africa, Prunus africana or Pygeum african.
It is an extract extracted from the bark of the um) tree using an organic solvent, etc., and is used as a folk medicine for bladder dysfunction in Atsuji. These substances are generally blackish brown semi-solid,
It has a specific odor. The method for producing the above extract is as follows:
A known method can be used, for example, first, bark is collected from an adult Prunus or Africana tree, coarsely ground into small pieces with a diameter of 3 cm or less, dried, further pulverized with a grinding layer, and immersed in a specific solvent such as chloroform. After extraction, the organic solvent is distilled off from the resulting extract, and the active ingredients can be separated and collected. The extract obtained in this way is generally a blackish brown semi-solid and is soluble in hair nourishment bases such as ethanol and vegetable oil.

Incidentally, the above-mentioned Prunus and Africana extracts have already been used for other purposes. That is,
It is used as a treatment for benign prostatic hyperplasia (Kuwana Pigenil) or as a skin cosmetic.

Moreover, a hair nourishment containing a skin peripheral vasodilator in addition to the above-mentioned Prunus and Africana extracts has a particularly favorable effect. Examples of such skin peripheral vasodilators include capronium chloride, benzyl nicotinate, vitamin E acetate, vitamin E acetate,
Examples include vitamin E nicotinate, and one or more of these may be used.

Next, the hair nourishing agent according to the present invention can be of various types such as lotion, emulsion, cream, oil gel, water-soluble gel, spray, etc., and the hair nourishing agent provided by the present invention can also be a hair styling agent having a hair nourishing effect. Needless to say, it is included in

In addition, the Prunus and Africana extracts can be blended as they are or dissolved in alcohol or the like, and then blended into the hair nourishment in the same manner as conventional medicinal ingredients are blended. The blending amount is approximately 0°0001 to 0.5% by weight, and the method of use is to apply the hair nourishing agent to the scalp once or twice a day. It is preferable to apply 1 coat and lightly pine serge or bat with a brush.

In addition, the hair care product according to the present invention may contain additives commonly used in hair care products, such as Prunus extract and Africana extract.
Hinokitiol, cationic surfactants, disinfectants such as parabens, cooling agents such as 1-menthol, hot pepper tincture,
Oils such as squalane and higher alcohols, other surfactants, fragrances, antioxidants, sunscreen agents, pigments, ethanol, water, and the like can be blended.

"Production Example" Next, a production example of the Prunus Africana extract used in the present invention will be shown.

Production example-1 Collect 3 kg of bark from an adult Prunus or Africana tree,
Cut by cutting, coarsely pulverize into small pieces with a diameter of 3 cm or less, dry and further pulverize with a pulverizer to powder, then add chloroform 32, install a reflux condenser, and after 4 hours of rapid flow, Filter and separate the extract. Next, the solvent was distilled off under reduced pressure to obtain Prunus Africana Extract 30Q.

The composition of the Prunus and Africana extract thus obtained was investigated and is shown in Table 1 below. Note that the composition of the above extract varies depending on the region of production, climate, extraction method, etc., so the Prunus and Africana extracts used in the present invention are not limited to these.

Hydrocarbon 2.10 Unister
53.3 Higher alcohol
1.0 Sterol derivative 6.0 Sterol 16.3 Triglyceride
4.4 Fatty acids 6
．． 7 "Example" Next, an example of the present invention will be shown.

Example 1 1 Hair material (a) (Lotion type) Weight % (Production method) The above formulation A was stirred and dissolved, and the above formulation B was added thereto and mixed to obtain a transparent liquid hair nourishing agent.

Example 2 1 Hair (TL) (0-john type) Weight % (Production method) A product was obtained in the same manner as in Example 1.

Example 3 Hair nourishing agent (emulsion type) Weight % (Production method) The above formulations A and B were heated to 80°C and mixed Fj
Both components were mixed and emulsified at the same temperature, and cooled to room temperature while stirring to obtain a product.

Example 4 Hair nourishing agent (cream type) Weight % r Squalane 30.0C fragrance
0.2 (Production method) The above formulation A is mixed and heated to 80°C. To this is added Formulation B, which has been mixed and heated to 80° C. in the same manner, and homogeneously emulsified with a homomixer, and the above C is added and cooled to obtain a product.

(The following is a blank space) "Effects of the Invention" Next, in order to confirm the safety of the Prunus and Africana extracts used in the present invention, a human batch test (20 men) was conducted, and the results are shown in Table 2.

The test method is as follows.

(a) 1 part of Prunus, African Chekis dissolved in 99 parts of wvj paraffin (b) Liquid paraffin test method: One drop of the above sample was placed on a lint cloth in an area of 0.05m, and the batch test was conducted. A plaster was applied to the back of the patient's back, removed after 24 hours, and a new one was applied, and the reaction state of the skin was observed after 48 hours. The judgment is ++: strong reaction, +: reaction, ±: weak reaction, -: no reaction Table 2 As described above, the Prunus Africana extract used in the present invention has no safety problems and is excellent It is a hair nourishing ingredient.

Next, in order to examine the hair growth effect of the Prunus and Africana extracts, an anti-androgen action test was conducted and the results are shown in Table 3. The greater the inhibition rate of sebaceous gland hypertrophy, the stronger the anti-androgenic effect. The test method is pl
ewig, G. et al. (J, of Invest, D.
ermatol.

68.171-176.1977) as follows.

Anti-androgenic effect test: Thirty female Syrian hamsters were subcutaneously injected with 1 ml of a 1.0% (w/v) liquid paraffin solution of testosterone propionate into the back twice every two days to enlarge the auricular intestinal line. These were divided into groups 1 to 3 of 10 animals each. Next, as a vehicle, equal volumes of ethanol and propylene are used.
Le equal capacity! Using the mixed solution, 1 group was placed in the ear pinna of the hamster.
The vehicle was applied once a day for 7 days, and the second group was similarly applied with a 1% vehicle solution of Prunus and Africana extract.
Groups were similarly treated with oxendron 1% vehicle solution. Next, a hamster ear tissue specimen was prepared, and the ear phase line cross-sectional area was measured using a branimeter. The catgut hypertrophy inhibition rate was calculated using the following formula. In addition, the catgut cross-sectional area of each group is 1
This is the average value for 0 animals.

Inhibition rate of catgut hypertrophy (%) - Table 3 Specimen Inhibition rate of catgut hypertrophy (%) Prunus, Africana 28.1 Exoxendron 25.0 or higher,
Prunus africana extract has an inhibitory effect on hamster auricular line hypertrophy induced by testosterone propionate, that is, it has an anti-androgenic effect.
The effect was equivalent to or better than that of oxendron, a commercially available anti-androgenic hormone.

Next, a hair growth effect test of the hair growth agent provided by the present invention was conducted, and the results are shown in Table 4.

The test method is as follows.

Hair growth effect test: Nine patients with androgenetic alopecia (age 29 to 48 years old) were tested, and the hair growth product of Example 1 was administered twice a day (2.01% per time).
111 administration) The product was administered to the hair removal area of the scalp while doing a light massage. This test was conducted for 3 months under the supervision of a doctor, and in the third month, the following three items were evaluated based on the doctor's judgment.

・Hair growth promotion effect +10: Increased hair growth.

+: Increased downy hair.

±; No change.

m: The hair removal site expanded.

・Anti-dandruff effect +: Decreased dandruff.

-No two changes.

- Handling has hair prevention effect +: Hair removal decreased.

−: No change.

Table 4 As shown above, the hair growth agent of the present invention had an excellent hair growth promoting effect, and was effective in the majority of patients with androgenetic alopecia.

This is considered a surprising effect at the current scientific level. It also exhibited excellent effects in preventing dandruff and hair loss, and no undesirable side effects such as hormonal effects were observed. Taking the above points together, the hair nourishing agent provided by the present invention is unprecedented, has excellent hair nourishing effects, and is highly safe.

Claims (2)

[Claims] (1) Prunus. Africana (Prunus afr)
A hair nourishing agent characterized by containing an extract obtained from the bark of A. icana. (2) Capronium chloride, benzyl nicotinate, vitamin E acetate, vitamin E linoleate,
The hair nourishment according to claim (1), which contains a skin peripheral vasodilator such as vitamin E nicotinate.