JPH0977639A - Hair tonic cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic cosmetic excellent in hair growing effect, preventing effect on loss of hair, a feeling in use and safety by using both an extract of tea leaves prepared by a specific treatment and an extract of Gentiana lutea Linne. SOLUTION: An extract of tea leaves obtained by preserving raw tea leaves under an anaerobic condition and heat-treating them with steam and/or in a dry state is combined with an extract of Gentiana lutea Linne. The amount of tea leaves mixed is about 0.0001-5.0wt.% calculated as an evaporation residue of the extract of tea leaves based on the total of the hair tonic cosmetic. As the extract of Gentiana lutea Linne, an extracted solution prepared by extracting a root and rhizome of Gentiana lutea Linne with water, ethanol, propylene glycol, 1,3-butylene glycol or its mixed solution and the evaporation residue prepared by concentrating the extracted solution to dryness. The amount of the extract of Gentiana lutea Linne mixed is about 0.0001-5.0wt.% calculated as the evaporation residue of the extract of Gentiana lutea Linne. The cosmetic is excellent in hair tonic effect and hair growing effect free from tackiness and a squeaky feeling by synergistic effects of each component.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair nourishing cosmetic composition which is excellent in hair-growth effect, hair loss prevention effect, feeling of use and safety.

[0002]

2. Description of the Related Art Conventionally, hair nourishing cosmetics are known which contain blood circulation promoting substances such as capsicum tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair. Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003]

However, the conventionally used blood circulation promoting substances have drawbacks such as strong skin irritation, a limited amount of the mixture, and a short duration of blood circulation promotion. In addition, there is also a problem that the hair nutrient has low permeability to the skin at a low concentration, and its effect is not sufficiently exhibited by itself.

By the way, androgenetic alopecia is said to be caused by an excessive action of androgen, but phenomena such as poor blood circulation, decreased activity of hair mother cells, hypertrophy of sebaceous glands, and fibrosis of scalp are caused. It is presumed that they are complicatedly intertwined.

However, in order to suppress the decrease in the activity of hair mother cells and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male hormones, even when an androgen inhibitor is simply used as a hair-growing agent, the hair-growing action is exhibited. The current situation is that it does not reach this level. Moreover, even if a hair matrix activating agent or a blood circulation promoting agent is used alone, good results cannot be obtained.

As means for solving the above-mentioned problems, a large number of hair nourishing and hair-growth agents have been proposed, including JP-A-5-58850, JP-A-5-1399336 and JP-A-5-170625. However, even if a substance that promotes peripheral blood flow and activates hair matrix cells is used alone, no remarkable hair-growth effect was found.

Further, in Japanese Patent Laid-Open No. 63-280009, an extract of tea leaves obtained by subjecting fresh tea leaves to anaerobic conditions and then steam heat treatment and / or dry heat treatment is referred to as a solid content thereof. A hair nourishing cosmetic composition containing 0.1% by weight or more has been proposed, but if the amount is less than 0.1% by weight, the hair-growth and hair-nourishing effects are not sufficiently exhibited, and 0.1% by weight or more is added. However, there has been a demand for further improvement in hair growth and hair-growth effects. Further, the hair nourishing cosmetics containing the extract of tea leaves also have a usability problem in that the tannin contained in the extract of tea leaves causes a tingling sensation on the hair.

Furthermore, in Japanese Patent Laid-Open No. 2-121911, 18-21% by weight of gentian extract, 14-18% by weight of carrot extract, 5-7% by weight of saffron extract, 16-20% by weight of touki extract. , Senkyu extract 29 ~
Although a hair-growth cosmetic composition containing 46% by weight and 1 to 5% by weight of the placenta extract has been proposed, since the present invention contains a high concentration of each extract in order to obtain a hair-growth effect,
There was a peculiar offensive odor, there was stickiness, the feeling of use was poor, and there was a case of skin irritation, which was a problem in practical use.

In view of such circumstances, the inventors of the present invention have conducted extensive studies on substances having an action of promoting peripheral blood flow in the scalp and activating hair mother cells, and as a result, have found that fresh tea leaves are anaerobically treated. A hair nourishing cosmetic containing a tea leaf extract obtained by steam heat treatment and / or dry heat treatment and a gentian extract after storage in the present invention is an object of the present invention due to the synergistic effect of each component. Excellent hair nourishing and hair-growth effect, with no sticky feeling and no squeaky feeling and excellent usability, and
It was found that there was no skin irritation, and the present invention was completed.

[0010]

[Means for Solving the Problems] That is, a tea leaf extract obtained by storing fresh tea leaves under anaerobic conditions and then steam heat treatment and / or dry heat treatment, and a gentian extract are contained. The hair nourishing cosmetics achieve the object of the present invention.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The tea leaf extract used in the present invention is an extract obtained by easily extracting by the method described in JP-A-63-280009, or obtained by concentrating and drying the extract. It is an evaporation residue. Specifically, plucked tea [Thea sinensis L. (Theaca
e)] The leaves are placed in a hermetically sealed container, and the air in the container is completely replaced with an inert gas such as carbon dioxide gas or nitrogen gas, and then at room temperature for 3 hours or more (preferably 5 hours or more, more preferably (8 hours or more) Leave (store). Next, the tea leaves are taken out of the container and subjected to steam heat treatment for 10 to 30 minutes, heat treatment at 80 ° C. to 100 ° C., or both in the same manner as in the usual tea manufacturing process. The types of green tea leaves to be subjected to the above treatment are Yabukita seeds,
Any kind of cultivar such as Beni Fuji can be applied, and the sampling time is not particularly limited. The extraction method of tea leaves is a common method, for example, in a extractor equipped with a reflux device, tea leaves in a solvent such as water, a water-miscible organic liquid, a mixture of a water-miscible organic liquid and water. Dip in a solvent at a boiling point of 30-
Extract for 60 minutes. This extract may be concentrated and dried under a reduced pressure, or may be purified by activated clay, a chromatography method or the like, if necessary.

Examples of the water-miscible organic liquid (hydrophilic organic liquid) in the above solvent include glycols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol and dipropylene glycol, and glycerin. , Polyhydric alcohols such as maltitols, lower monohydric alcohols such as ethyl alcohol, propyl alcohol and butyl alcohol, water-miscible ketones such as acetone and methyl ethyl ketone, and tetrahydrofuran.

The amount of the tea leaf extract used in the present invention is determined as a result of examining the ranges showing the hair growth effect, hair loss prevention effect, and safety to the skin, which are the objects of the present invention, and as a result, the total amount of hair nourishing cosmetics is determined. As a standard, it is 0.
0001 to 5.0 wt% (hereinafter abbreviated as wt%) is preferable, and 0.002 to 0.5 wt% is more preferable.
Is preferable from the viewpoints of hair-growth effect, hair loss-preventing effect, and feeling of use (no sticky feeling and no tingling sensation).

The extract of gentian used in the present invention means gentiana lutea.
Linne (Gentianaceae)], water, ethanol, propylene glycol,
It is an extract obtained by extracting with 1,3-butylene glycol or a mixed solution thereof, or an evaporation residue obtained by concentrating and drying the extract.

The amount of the gentian extract used in the present invention was determined as a result of examining the ranges showing the hair growth effect, hair loss prevention effect, and safety to the skin, which are the objects of the present invention. On the basis of 0.0001 to 5.0% by weight (hereinafter referred to as wt%) in terms of evaporation residue of the gentian extract.
Is abbreviated), and more preferably 0.002-
0.5 wt% is preferable from the viewpoints of hair-growth effect, hair loss prevention effect, and feeling of use (no sticky feeling and no tingling sensation).

The hair nourishing cosmetic composition of the present invention can be prepared according to a conventional method, for example, a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner.
It can be manufactured and used in a dosage form such as hair gel, hair mist, and hair foam.

The hair nourishing cosmetic composition of the present invention is applied or sprayed to a desired topical region (scalp) according to its dosage form to prevent hair nourishment, hair growth and / or hair loss.

The hair nourishing cosmetic composition of the present invention includes dyes, fragrances, bactericides, antiseptics, keratolytic agents, antiandrogens,
Antioxidants and the like can be appropriately added within a range that achieves the object of the present invention.

[0020]

The present invention will be described in detail below with reference to examples, but the present invention is not limited thereto. The test method used in the present invention is as follows.

(1) Test Method for Mouse Hair Growth Promoting Effect C3H mice (male, 8 weeks old, average weight 35 g) were shaved at the center of the back with electric clippers, and then completely shaved by a shaver. From the next day, 0.2 ml per animal of each sample of Example and Comparative Example was applied once daily to the skin of the test site. For each sample, 10 animals were used per group. In addition, the base alone (control product) was applied as a control group. On the 14th day after the start of the experiment, the animals were sacrificed and photographs of the skin of the test area were taken. Next, import the photo into the image analysis device,
First, the area (A) where the hair was shaved and the hair-growth area (B) were obtained, and the hair-growth rate (%) = [(B) / (A)] × 100 was calculated for each animal. Finally, a value obtained by dividing the average value of each group of Examples or Comparative Examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Human hair growth promoting effect test method Male subject 1 in the thirties and forties with a decline in hair growth 1
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm. One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 12
Volume 5, p. 123, 1991), the hair growth rate was determined for the hair (about 30-40 hairs) at the target site, and the average value was calculated (A). Next, focusing on the test site for each subject, samples of the examples, comparative examples and control products were twice daily in the morning and evening,
About 3 ml was applied and massaged well. The hair growth rate of the same site is measured in the same manner on the 3rd month after the start of the test.
The average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method Twenty male pattern baldness heads were exposed to the head twice daily in the morning and evening for 6 consecutive times.
The effect after applying the sample for a month was evaluated. The test results, for each item of hair growth effect and hair loss prevention effect,
The number of respondents who responded that "downy hair was bristled or bristles increased" and "hair loss decreased" was shown.

(5) Feeling test method Ten panelists of 10 men applied the respective samples to hair, and the results of the questionnaire for stickiness and crease were evaluated as follows.

[0025]

[Table 1]

The tea leaf extract and the gentianian extract used in the following Examples and Comparative Examples were produced by the following production method.

(1) Extract of tea leaves 10 kg of fresh tea leaves are left under a nitrogen stream for 4 hours to be mashed, then roasted in a kettle and dried. Purified water 3
Add 0 l, heat for 2 hours, extract, cool, and filter. 20 l of purified water is added to the residue, and the same operation is performed twice. The filtrates were combined, to which 20 l of a synthetic adsorbent (manufactured by Mitsubishi Kasei Co., Ltd., Diaion HP-20) was added, and the mixture was stirred at room temperature for about 2 hours, filtered, and the filtrate was concentrated under reduced pressure to give a concentrate of about 1 0.0 kg was obtained. To this, absolute ethanol of about 0.
After adding 4 kg and leaving it in a cold place for 7 to 10 days, the sediment and the precipitate formed were removed, and a 30 vol% ethanol solution was added to obtain 1.5 kg of a product. This product was a brown transparent liquid and had a slightly peculiar odor. The evaporation residue of this product was 5 to 10% by weight.

(2) Method for producing gentian extract After extracting 1000 g of dried roots of "Gentian" by heat with purified water for about 12 hours, 400 g of propylene glycol as a stabilizer was added, and further purified water was added, Extract 1
000 g were obtained. This product was a light brown transparent liquid with a slightly peculiar odor. The evaporation residue of this product was 2 to 6% by weight.

Examples 1-5, Comparative Examples 1-6, Control Product (Heartonic) In the raw material composition shown in Table 2, the active ingredients were blended as shown in Table 3 to prepare a hairnic, and the various tests described above were conducted. Was carried out.

[0030]

[Table 2]

[0031]

[Table 3]

(1) Preparation Method After dissolving the component (B) shown in Table 2 in the component (A), the component (C) was added, and the mixture was stirred and dispersed to fill a container. At the time of use, the content was uniformly dispersed by shaking before use.

(2) Characteristics Table 3 shows the results of various tests conducted on each heartnic. As shown in Table 3, in Comparative Examples 1 to 5, the mouse hair growth promoting effect and the human hair growth promoting effect were low, and the results of the practical test and the feel test were also inferior. On the other hand, the hair artics of the present invention of Examples 1 to 5 showed a high mouse hair growth promoting effect and human hair growth promoting effect, and the results of practical tests were also good. In addition, when the hair nick of each example was used, there was no sticky feeling or creaking feeling during use, and the feeling during use was excellent. Furthermore, inflammation in mice and humans,
No other side effects were observed, and it was clear that the hair nick of the present invention has excellent safety. The hair growth rates of the control products in Table 3, Comparative Examples 2, 3, 5 and 6 and the hairnic mice of Example 2 were as follows:
The result of examining the difference between samples by t-test is shown in FIG.
As a result, it was clear that Example 2 had a prominent hair growth promoting action at a risk rate of 1%, as compared with the control product and Comparative Examples 2, 3, and 5.

[0034]

EFFECTS OF THE INVENTION The hair nourishing cosmetic composition of the present invention is excellent in hair-growth effect and hair loss prevention effect, and is excellent in feeling of use without stickiness and tingling sensation and also in safety.

[Brief description of drawings]

FIG. 1 is a graph showing the hair growth rates of mice of Examples, Comparative Examples and Control products.

Front page continuation (72) Inventor Tatsuo Oshima 5-3 28, Kotobuki-cho, Odawara-shi, Kanagawa Kanebo Co., Ltd.

Claims (1)

[Claims] Claims 1. After storing fresh tea leaves under anaerobic conditions,
A hair nourishing cosmetic comprising a tea leaf extract obtained by steam heat treatment and / or dry heat treatment, and a gentian extract.