JP2534010B2 - Hair growth and hair growth materials - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a hair growth / hair-growth agent, and more specifically, it does not provide a hair growth / hair-growth agent having excellent hair growth / hair-growth effects and stability and safety that can withstand long-term use. It is what

[0002]

2. Description of the Related Art Conventionally, various known herbal extracts or various compounds have been blended with known hair growth and hair growth materials. For example, as a crude drug extract, extracts such as Yokuinin, Ginkgo biloba, Kashi, etc.
Japanese Patent Laid-Open No. 2-48512, Japanese Patent Laid-Open No. 2-48
514 etc.), and as compounds, vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ′, 5′-cyclic monophosphate, etc. (JP-A-64-56608, Kaihei 1-2613
21 and JP-A-2-204406).

[0003]

However, as described in the above-mentioned examples, various crude drug extraction exhausts and various compounds are applied to the hair growth and hair-growth agents that have been known so far. Almost no effect was exhibited, and those having a certain degree of effect had drawbacks such as strong irritation to cause dermatitis and difficulty in continuous use. Accordingly
Therefore, it is desired to provide a hair growth / hair-growth material that has excellent hair growth / hair-growth effects and is safe enough to withstand long-term use.
That was the challenge in this area .

[0004]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that there is a component having an excellent hair-growing / hair-growing effect for sericulture, and based on this, The present invention has been completed. That is, the present invention is characterized in that the extract obtained by extracting the water-soluble organic solvent or the water-containing water-soluble organic solvent from the silkworm sand is blended in the base material in an amount of 0.001 to 10% by weight (dry matter conversion). The present invention relates to a hair growth / hair growth material.

The present invention will be described in detail below. The silkworm applied to the present invention is dried feces of domestic silkworm moth ( Bombyx mori L.) larvae of the Bombycidae family. Other names are also known as Hara silkworm, silkworm, silkworm, evening silkworm, horse-meat liver, evening silkworm, and two silkworms. This silkworm sand is sometimes used for the treatment of rheumatism and arthritis, but no examples of verifying the hair growth and hair-growth effect have been found, and the present inventors have found it for the first time. Next, one example of a method for producing an extract having a hair growth / promotion effect from silkworm sand will be described. Silkworm sand is a water-soluble organic solvent, for example, primary alcohol such as methanol, ethanol, propanol, butanol, polyhydric alcohol such as 1,3-butylene glycol, propylene glycol. Water, a water-soluble organic solvent of acetone, tetrahydrofuran or dioxane alone, or a water-containing water- soluble organic solvent containing 50% by weight or more of the above-mentioned primary alcohol, polyhydric alcohol, acetone, tetrahydrofuran or dioxane, and further these. Cold-extract or warm-extract extraction with the mixed solvent of
To get . Furthermore, specifically, using 0.5 to 5 liters of solvent for 100 g of silkworm sand, at room temperature to the boiling point of the extraction solvent, at room temperature for 7 to 10 days, at heating for 4 to 8 hours, at 1 to 2 Extract twice. The extracts are combined, filtered with suction, and concentrated under reduced pressure to remove the solvent, to obtain a viscous or dry silkworm extract. Below, the example of manufacture of a typical silkworm sand extract is shown.

[ Production Example 1 ] 100 g of silkworm sand was soaked and extracted with 1 liter of 70% ethanol at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract. Was obtained (yield 1.3%). [ Production Example 2 ] 100 g of silkworm sand was soaked in 1 liter of ethanol, and sock tray
Transfer to extractor and perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 2%). [ Production Example 3 ] 100 g of silkworm sand was immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and extracted by heating for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 2.6%). [ Production Example 4 ] 100 g of silkworm sand was immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and extracted by heating for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 1.5%). [ Production Example 5 ] 100 g of silkworm sand was immersed in 1 liter of an extraction solvent of propylene glycol: distilled water = 1: 1, and transferred to a Soxhlet extractor,
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 1.5%). [ Production Example 6 ] 100 g of silkworm sand was dipped in 1 liter of 1,3-butylene glycol, transferred to a Soxhlet extractor, and extracted by heating for 7 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 0.8%).
The extract thus obtained is blended in the base as it is or after being dissolved, dispersed and diluted with an appropriate solvent or the like. At this time, the blending amount of the extract (converted to dry matter) is selected from the range of 0.001 to 10% by weight, preferably 0.05 to 5% by weight, based on the base. If the blending amount is less than 0.001% by weight, the hair-growth effect is not sufficiently exhibited, and even if the amount is more than 10% by weight, the effect is not enhanced and the stability as a hair-growth / hair-growth agent cannot be sufficiently guaranteed. Other raw material components used in the hair growth / hair growth material of the present invention include hydrocarbons, waxes, oils and fats, esters, which are usually applied to hair growth / hair growth material.
Higher fatty acids, higher alcohols, surfactants, fragrances, dyes, preservatives, antioxidants, UV protectors, alcohols,
A pH adjuster, a medicinal component suitable for the purpose of the present invention and the like are appropriately selected and prepared. Further, it can be used in combination with a known hair growth / hair growth ingredient. Next, the hair growth of the present invention
The dosage form of the hair-growth agent is not particularly limited, and examples thereof include various dosage forms such as hair tonic, shampoo, conditioner, pomade, hair lotion, hair cream, and hair treatment.

Here, the results of evaluation of the effect of the silkworm sand extract according to the present invention on the hair growth of mice will be shown. (Sample) 70% ethanol aqueous dispersion containing 5% of 70% ethanol extract from silkworm (Production Example 1) according to the present invention, and a comparative product known as a substance having a hair-growth / hair-growth effect. 70% containing 1% of vitamin E
An aqueous ethanol dispersion and a 70% aqueous ethanol solution as a solvent were used as controls. (Test method) Using 9-week-old C3H mice,
There are 0 animals, 4 groups are made, and 2.0 x 2.0c of these backs
After removing hair, remove each sample 0.0
After applying 4 g, the density of hair growth at the site was captured as the degree of increase in blackness using a color difference meter on the 16th day. Table 1 shows the results.

[0008]

[Table 1]

As is clear from the results shown in Table 1, the silkworm extract according to the present invention has a reduced L value and an increased black color. On the other hand, the vitamin E of the comparative product showed almost no decrease in L value. This is presumed to be the result of the silkworm extract according to the present invention stimulating hair roots, making blood circulation around hair follicles more active, and activating metabolism.

[0010]

EXAMPLES The present invention will be described in more detail below with reference to examples and comparative examples. The blending amount is parts by weight. [ Examples 1 and 2 and Comparative Example 1 ] Hair tonic type hair growth material

[0011]

[Table 2]

Next, a human hair growth / hair growth effect test was conducted to evaluate the hair growth / hair growth material of the present invention. (Sample) The hair tonic type hair regrowth agents of Examples 1 and 2 and Comparative Example 1 were used. (Test method) Fifteen panellers who complain of thinning hair and alopecia were divided into three groups of five persons each, and Examples 1 and 2 (product of the present invention),
A hair-growth / hair-growth effect test was carried out by continuously using the hair tonic-type hair regrowth agent of Comparative Example 1 (comparative product) for 6 months. Usage is the same as normal tonic usage 2 a day
The method of applying evenly on the head and the head was used. The evaluation was performed 3 months and 6 months after the start of use, and the extent to which the number of subjects who felt that the vellus hair and vellus had increased increased was measured. Also, they were asked to report improvement in the condition of the scalp at the end of the test and a reduction in the occurrence of dandruff. Table 3 shows the results.

[0013]

[Table 3]

As is clear from the results shown in Table 3, the hair tonic type hair regrowth agent of the present invention containing the silkworm sand extract according to the present invention in a certain amount or more produced vellus hair and bristles. It has been proved to have a hair growth effect from the increasing number of people. On the other hand, it was found that the effect was not detected in the comparative hair tonic type hair growth composition containing 0.0005% of the silkworm sand extract. At the end of the test, the number of persons who reported improvement in scalp condition and reduction in the occurrence of dandruff in Example 1 and 3 in Example 2 were counted. From this, a hair tonic containing the silkworm extract of the present invention was also found to have a hair-growing effect. Furthermore, during the use test period, no skin damage such as deterioration of scalp condition or inflammatory reaction was observed in any of the panelers, which confirmed that the product of the present invention has high safety.

[0015] Example 3 Hair tonic Kosuna 70% ethanol - Le extract (Production Example 1) 3.0 Instrument - Le 0.2 ethanol - le 50.0 Vitamin E 0.05 propylene glycol - Le 5.0 Vitamin B ₂ 0.5 Purified water 37.85 Yeast extract liquid (nucleic acid-containing) 0.5 glycyrrhizin dipotassium 0.3 diphenhydramine hydrochloride 0.3 methylparaben 0.2 perfume 0.1 (Production method) ethanol - Kosuna extract Le, instrument - Le, advance by dissolving vitamin E, then propylene glycol - le, vitamin B _2, It is manufactured by adding yeast extract (containing nucleic acid), dipotassium glycyrrhizin, diphenhydramine hydrochloride, purified water in which methylparaben is dissolved and a fragrance.

[Example 4] Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10cs) 2.0 Cetanol 4.0 Silkworm sand 1,3-butylene glycol extract (Production Example 6) 4.5 (B) Stearyl trimethyl chloride Ammonium 3.0 Distearyldimethylammonium 0.5 Propyrin glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 40.09 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 Perfume 0.1 ( Manufacturing method) Each of A and B is heated to 80 ° C, and both are mixed and emulsified. After that, it is cooled to around 40 ° C., and at that time, C is added and a fragrance is added to obtain a product.

[0017] Example 5 Hair Shampoo - (A) lauryl sulfate triethanolamine - triethanolamine 10.0 Sodium lauryl sulphate 5.0 coconut Jietano - Ruamido 2.0 Pro pilin glycolate - Le 5.0 Piroctone olamine 0.25 silkworm sand acetone extract (Production Example 3 ) 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.4 Perfume 0.1 (Production method) A is mixed at 80 ° C, then cooled to around 40 ° C, B is added, and the perfume is further added to obtain a product.

[0018] Example 6 rinses (A) Liquid paraffin 0.5 methylpolysiloxane (10 cs) 0.5 Setano - Le 2.0 stearyl triethyl ammonium chloride 3.0 Kosuna ethanol - Le extract (Production Example 2) 2.0 (B) 1, 3 -Butylene glycol 5.0 Purified water 40.0 (C) Diphenhydramine chloride 0.25 Glycyrrhizin dipotassium 0.25 Purified water 46.4 Perfume 0.1 (Production method) A and B are heated to 80 ° C. and mixed at that time to emulsify. After that, the product was cooled to about 40 ° C., C was added, and then a fragrance was added.

[0019] Example 7 Heakuri - beam (A) Kosuna 70% ethanol - Le extract (Production Example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20 EO) Sechirue - ether 3.0 Glyceryl monostearate Ares -To 2.0 (B) Purified water 32.2 Propylene glycol 5.0 Diphenhydramine chloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 Perfume 0.1 (Production method) The composition of A was mixed and dissolved at 80 ° C., and then beforehand.
B, which had been heated to 80 ° C., was gradually added to A to form a cream. After that, it was cooled to 40 ° C., and a fragrance was added to obtain a product.

[0020]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a highly safe hair-growth / hair-growth agent which has excellent hair-growth / hair-growth effects and is free from skin disorders even after long-term continuous use.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Katsuo Matsumoto 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Polar Chemical Industry Co., Ltd. Totsuka Laboratory (72) Hideo Kuroda 560, Kashio-cho, Totsuka-ku, Yokohama, Kanagawa Kasei Kogyo Co., Ltd. in the Totsuka Laboratory (72) Inventor Masami Suzuki 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Polar Chemical Industry Co., Ltd. in the Totsuka Laboratory

Claims (1)

(57) [Claims] 1. From a silkworm, a water-soluble organic solvent or a water-containing aqueous solution
The extract obtained by extraction with a volatile organic solvent was added to the base in an amount of 0.001
Hair growth and hair-growth material characterized by being mixed up to 10% by weight (dry matter conversion).