JPH06100422A - Trichogenous and hair-growing agent - Google Patents

Abstract

PURPOSE:To provide a trichogenous and hair-growing agent having excellent trichogenous and hair-growing effects and high safety. CONSTITUTION:Silkworm waste is extracted with water and/or a water-soluble organic solvent and the extract is compounded to a base in an amount of 0.001-10wt.%, preferably 0.05-5wt.%.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a hair growth / hair-growth agent, and more specifically, it does not provide a hair growth / hair-growth agent having excellent hair growth / hair-growth effects and stability and safety that can withstand long-term use. It is what

[0002]

2. Description of the Related Art Conventionally known hair growth and hair-growth ingredients have been mixed with various herbal medicine extracts or various compounds. For example, the herbal medicine extract is an extract such as Yokuinin, Ginkgo biloba, and Kashi (Japanese Patent Publication No. 1-1345).
No. 1, JP-A-2-48512, JP-A-2-4
8514, etc.), and as compounds, vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ′, 5′-cyclic monophosphate, etc. (JP-A-64-56608, JP-A-1-56608). 2613
21 and JP-A-2-204406).

[0003]

However, as described in the above examples, various herbal medicine extracts and various compounds have been applied to the hair-growth and hair-growth agents that have been known so far. Almost no effect was exhibited, and those having a certain degree of effect had drawbacks such as strong irritation to cause dermatitis and difficulty in continuous use. The present invention has been made in view of such circumstances, and an object of the present invention is to provide a hair-growth / hair-growth material which is excellent in hair-growth / hair-growth effects and has sufficient safety to withstand long-term use.

[0004]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that there is a component having an excellent hair-growing / hair-growing effect for sericulture, and based on this, The present invention has been completed.

[0005] That is, the present invention, from the silkworm sand to water and /
Alternatively, the present invention relates to a hair-growth / hair-growth material, characterized in that the extract obtained by extraction with a water-soluble organic solvent is added to the base in an amount of 0.001 to 10 wt%.

The present invention will be described in detail below.

[0007] The silkworm sand applied to the present invention is dried feces of domestic silkworm moth ( Bombyx mori L.) larvae of Bombycidae. Other names are also known as Hara silkworm, silkworm, silkworm, evening silkworm, horse-meat liver, evening silkworm, two silkworms. This silkworm sand is sometimes used for the treatment of rheumatism and arthritis, but no example of verifying the hair growth and hair-growth effect has been found, and the present inventors have found it for the first time.

Next, regarding a method for producing an extract having a hair growth / promotion effect from silkworm sand, the silkworm sand is treated with water and / or
Or a water-soluble organic solvent, for example, a primary alcohol such as methanol, ethanol, propanol, butanol,
1,3-butylene glycol, polyhydric alcohol such as propylene glycol, or an organic solvent of acetone, tetrahydrofuran, dioxane alone or a water-containing organic solvent containing 50% by weight or more of the primary alcohol, polyhydric alcohol or acetone, tetrahydrofuran, dioxane, Further, cold soaking or warm soaking extraction is performed with these mixed solvents.

Specifically, 0.5 to 5 liters of a solvent is used per 100 g of silkworm sand, and the temperature is from room temperature to the boiling point of the extraction solvent at room temperature for 7 to 10 days and at heating for 4 to 8 hours. 1-2
Extract twice. The extracts are combined, filtered with suction, and concentrated under reduced pressure to remove the solvent, to obtain a viscous or dry silkworm extract. Below, the example of manufacture of a typical silkworm sand extract is shown.

Production Example 1 100 g of silkworm sand was extracted by immersion in 1 liter of 70% ethanol at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.3
%)

Production Example 2 100 g of silkworm sand was immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2%)

Production Example 3 100 g of silkworm sand was immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and extracted by heating for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 4 100 g of silkworm sand was immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.5%)

Production Example 5 100 g of silkworm sand was mixed with propylene glycol: distilled water = 1: 1.
It is immersed in 1 liter of the extraction solvent of 1), transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.5%)

The extract obtained as described above is blended in the base as it is or after being dissolved, dispersed and diluted with an appropriate solvent or the like. At this time, the amount of the extract to be mixed (dry matter conversion) is selected in the range of 0.001 to 10% by weight, preferably 0.05 to 5% by weight, based on the base. If the blending amount is less than 0.001% by weight, the hair-growing effect is not sufficiently exhibited,
Further, even if the amount exceeds 10% by weight, the effect is not enhanced and the stability as a hair-growth / hair-growth agent cannot be sufficiently ensured.

Other raw material components used in the hair growth / hair growth material of the present invention include hydrocarbons, waxes, oils and fats, esters, higher fatty acids, and higher grades which are usually applied to hair growth / hair growth materials. Alcohols, surfactants, fragrances, dyes, preservatives, antioxidants, ultraviolet protective agents, alcohols, pH adjusters, and medicinal ingredients suitable for the purpose of the present invention are appropriately selected and prepared. Further, it can be used in combination with a known hair growth / hair growth ingredient.

Next, there is no particular restriction on the dosage form of the hair-growth / hair-growth material of the present invention. For example, hair tonic, shampoo,
Various dosage forms such as rinses, pomades, hair lotions, hair creams and hair treatments can be mentioned.

The results of evaluation of the effect of the silkworm sand extract according to the present invention on the hair growth of mice are shown below.

(Sample) A 70% ethanol aqueous dispersion containing 5% of an ethanol extract from silkworm sand according to the present invention,
70% ethanol aqueous dispersion containing 1% of vitamin E, which has been conventionally known as a substance having hair-growth and hair-growth effects, as a comparative product, and a solvent of 70% as a control.
An aqueous solution of ethanol was used.

(Test method) Using 9-week-old C3H mice, one group has 10 mice, and 4 groups are prepared.
After removing 0.04 g of each sample on the site where hair was removed to a width of 0 × 2.0 cm on the next day after hair removal, on the 16th day, the density of hair growth of the site was measured as a degree of black increase using a color difference meter. I caught it. The results are shown in Table 1.

[0021]

[Table 1]

As is clear from the results shown in Table 1, it is understood that the L-value is decreased and the black color is increased in the silkworm sand extract according to the present invention. On the other hand, the vitamin E of the comparative product showed almost no decrease in L value. This is presumed to be the result of the silkworm extract according to the present invention stimulating hair roots, making blood circulation around hair follicles more active, and activating metabolism.

[0023]

EXAMPLES The present invention will be described in more detail below with reference to examples and comparative examples. The blending amount is parts by weight.

Examples 1 and 2 and Comparative Example 1 Hair tonic type hair growth material

[0025]

[Table 2]

Next, a human hair growth / hair growth effect test was conducted to evaluate the hair growth / hair growth material of the present invention.

(Sample) Examples 1 and 2 and Comparative Example 1
The hair tonic type hair growth material of was used.

(Test method) Complain about thinning hair and alopecia 15
The five panelists were divided into three groups of five, and the first and second examples were performed.
(Invention product), hair tonic type hair growth material of Comparative Example 1 (comparative product) was used for 6 consecutive months to carry out a hair growth / hair growth effect test. As a method of use, a method of evenly applying to the head twice a day was used as in the normal tonic method. The evaluation is performed at the 3rd and 6th months after the start of use,
The extent to which the number of subjects who felt that their downy hairs and terminal hairs had increased increased was measured. In addition, at the end of the test, they were asked to report improvements in their scalp condition and a decrease in the occurrence of dandruff. The results are shown in Table 3.

[0029]

[Table 3]

As is clear from the results shown in Table 3, the hair tonic type hair regrowth material of the present invention containing the silkworm sand extract according to the present invention in a certain amount or more produced vellus hair and bristles. It has been proved to have a hair growth effect from the increasing number of people. On the other hand, it was found that the effect was not detected with the comparative hair tonic type hair regrowth that contained 0.0005% of the silkworm sand extract.

At the end of the test, the condition of the scalp was improved, and the person who declared that the occurrence of dandruff was reduced to 3 in Example 1.
In the first example and in Example 2, one person was counted. From this, a hair tonic containing the silkworm extract of the present invention was also found to have a hair-growing effect.

Further, no skin damage such as deterioration of scalp condition or inflammatory reaction was observed in any panel during the use test period, which confirms that the product of the present invention has high safety. It was

Example 3 Hair Tonic Silkworm Ethanol Extract 3.0 Menthol 0.2 Ethanol 50.0 Vitamin E 0.05 Propylene Glycol 5.0 Vitamin B2 0.5 Purified Water 37.85 Yeast Extract (containing nucleic acid) ) 0.5 Glycyrrhizin dipotassium 0.3 Diphenhydramine hydrochloride 0.3 Methylparaben 0.2 Perfume 0.1 (Manufacturing method) A silkworm sand extract, menthol and vitamin E are dissolved in ethanol, and then propylene glycol, vitamin B2 and yeast are dissolved. An extract (containing nucleic acid), dipotassium glycyrrhizin, diphenhydramine hydrochloride, purified water in which methylparaben is dissolved, and a fragrance are added for production.

Example 4 Hair Treatment (A) Liquid Paraffin 2.0 Methylpolysiloxane (10 cs) 2.0 Cetanol 4.0 Silkworm 1,3-butylene glycol extract 4.5 (B) Stearyltrimethylammonium chloride 3 0.0 Distearyldimethylammonium chloride 0.5 Propyrin glycol 5.0 Piroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract extract 0.5 Purified Water 40.09 Diphenhydramine hydrochloride 0.25 Methylparaben 0.2 Perfume 0.1 (Production method) A and B are each heated to 80 ° C., and both are mixed and emulsified. After that, it is cooled down to around 40 ° C., and at that time, C is added and a fragrance is further added to obtain a product.

Example 5 Hair Shampoo (A) Lauryl Sulfate Triethanolamine 10.0 Sodium Lauryl Sulfate 5.0 Coconut Oil Diethanolamide 2.0 Propyrin Glycol 5.0 Piroctone Oramine 0.25 Silkworm Acetone Extract 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.4 Perfume 0.1 (Production method) A is mixed at 80 ° C., then cooled to around 40 ° C., B is added, and the fragrance is further added. Add to make a product.

Example 6 Hair Rinse (A) Liquid Paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium Chloride 3.0 Silkworm Ethanol Extract 2.0 (B) 1,3- Butylene glycol 5.0 Purified water 40.0 (C) Diphenhydramine hydrochloride 0.25 Glycyrrhizin dipotassium 0.25 Purified water 46.4 Perfume 0.1 (Production method) A and B were heated to 80 ° C., respectively. Mix and emulsify. Then cool down to around 40 ° C,
C was added, and then a fragrance was added to obtain a product.

Example 7 Hair Cream (A) Silkworm 70% Ethanol Extract 2.5 Vaseline 7.0 Beeswax 8.0 Liquid Paraffin 37.0 Polyoxyethylene (20EO) Cetyl Ether 3.0 Glyceryl Monostearate 2 0.0 (B) Purified water 32.2 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Glycyrrhizin dipotassium 0.2 Ethylparaben 0.3 Perfume 0.1 (Production method) The composition of A was mixed and dissolved at 80 ° C. Next, B preheated to 80 ° C. was gradually added to A to form a cream. Then, it cooled to 40 degreeC, and added the fragrance | flavor, and set it as the product.

[0038]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a highly safe hair-growth / hair-growth agent which has excellent hair-growth / hair-growth effects and is free from skin disorders even after long-term continuous use.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Katsuo Matsumoto 560 Kashio-cho, Totsuka-ku, Yokohama, Kanagawa Pola Chemical Industry Co., Ltd.Totsuka Research Institute (72) Hideo Kuroda 560 Kashio-cho, Totsuka-ku, Yokohama, Kanagawa Pola Kasei Kogyo (72) Inventor Masami Suzuki, 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Pola Chemical Industry Co., Ltd.

Claims (1)

[Claims] 1. An extract obtained by extracting water and / or a water-soluble organic solvent from silkworm sand in an amount of 0.001
Hair growth and hair restoration material characterized by being mixed in an amount of 10% by weight.