JPH10287531A - Cosmetic for hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject high stable cosmetic having excellent hair restoring and growing effects, which promotes and normalizes the function of hair and head skin and makes them healthy by formulating a ginkgo extract containing a prescribed amount of a specific component as a hair restoring component. SOLUTION: The objective cosmetic is obtained by formulating (A) 0.00001-10 wt.% (dry solid) of ginkgo extract containing the whole flavonoid and the whole terpenoid in amounts of 15-40 wt.% and 2-15 wt.%, respectively, with (B), when necessary, a base such as emulsion, gel and aerosol, purified water, lower alcohol, oils and fats, surfactant, thickener, pigment, perfume and pharmaceutically active ingredient. The A component is obtained by chopping or grinding leaves of Ginkgo biloba picked just before turning yellow preferably in the early autumn, extracting by immersing it into an extraction solvent (e.g. 50 v/v% mixed solvent of ethyl alcohol and water), when necessary, carrying out concentration under reduced pressure, centrifugal separation and filtration, and then purifying.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic for hair containing a ginkgo biloba extract containing a certain amount of a specific component as an essential component, and an object thereof is to enhance and normalize the functions of hair and scalp. And to provide a hair cosmetic having an excellent hair-growth and hair-growth effect to make the hair healthy.

[0002]

2. Description of the Related Art Various hair cosmetics have been used for preventing and treating various physiological symptoms such as baldness, thinning hair, dandruff and seborrhea. These hair cosmetics are formulated with drugs having various effects such as promotion of blood circulation of the scalp, suppression of lipid secretion, activation of hair cells, and so far, these drugs have sufficient effects. I couldn't say that. Recently, plant extracts such as crude drugs have been attracting attention as a hair-growing component to be incorporated into hair cosmetics from the viewpoints of efficacy and safety. Among these crude drug extracts, ginkgo extract has been proposed as a drug showing an excellent hair-growing effect (JP-A-2-48512). However, although this ginkgo extract is more effective than conventional hair cosmetics containing other plant extracts, it has a satisfactory and sufficient hair-growth effect within a range that does not cause inconvenience in formulation. I haven't gotten it.

[0003]

Therefore, there has been a demand for the development of a cosmetic for hair which is safer and has excellent hair-growth and hair-growth effects.

[0004]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies in view of such circumstances, and as a result, the conventional ginkgo extract has been further purified to increase the content of specific components to a certain level or more, thereby improving hair growth and hair growth. It was found that the hair growth effect was enhanced. That is, it has been found that a cosmetic for hair exhibiting more excellent hair-growth and hair-growth effects can be obtained by purifying so that the total flavonoid content is 15 to 40% by weight and the total terpenoid content is 2 to 15% by weight. Completed the invention.

[0005] That is, the present invention is characterized in that the composition of the hair contains ginkgo biloba extract having a total flavonoid content of 15 to 40% by weight and a total terpenoid content of 2 to 15% by weight as essential components. Provide cosmetics.

[0006]

DETAILED DESCRIPTION OF THE INVENTION The ginkgo extract used as an essential component in the present invention is Ginkgo (Ginkgo).
biloba L. ) Extracted from leaves. The timing of collecting ginkgo leaves is not particularly limited, but the leaves immediately before yellowing in early autumn are most desirable in order to obtain the target component efficiently. The method for preparing the ginkgo extract is also not particularly limited. For example, the extract can be obtained by extracting with various appropriate solvents at a low temperature or at room temperature to heating, and then purifying.

[0007] Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; Can be used. In particular, a water mixed solvent such as 50 v / v% ethyl alcohol and 50 v / v% acetone is desirable for efficiently obtaining the target component.
Examples of the extraction method include a method of chopping or pulverizing the original plant, adding an extraction solvent, extracting by immersion at room temperature or under heating, and performing vacuum concentration, centrifugation, filtration, or the like as necessary. . Examples of the purification method include an ion exchange resin, a method by column chromatography using a carrier such as silica gel, a partitioning method using a suitable solvent such as hexane, ethyl acetate, acetone, methyl ethyl ketone, ethyl alcohol, and water. The operation removes hydrophobic substances such as chlorophyll, carotenoids, aliphatic hydrocarbons and low-polar phenols, and high-polar compounds such as sugars and tannins. In order to remove hydrophobic substances, it is desirable to remove the hexane-soluble part and / or the 50 v / v% ethyl alcohol-insoluble part of the crude extract. It is desirable to apply the extract to a column such as 20 (Mitsubishi Kasei) and wash it with water and a high-hydric alcohol (0 to 30 v / v%) to remove it.

[0008] The content of the ginkgo extract in the composition of the present invention is preferably 0.00001 to
It is in the range of 10% by weight (hereinafter simply indicated by "%"), and more preferably in the range of 0.001 to 1%. The content of the total flavonoid is preferably 0.000001.
In the range of 5-4%, more preferably 0.00015.
０．４0.4%. The total terpenoid content is preferably in the range of 0.0000002 to 1.5%, and more preferably in the range of 0.00002 to 0.15%.

[0009] The ginkgo biloba extract of the present invention is prepared according to a conventional method.
For example, a hair tonic, a hair liquid, a hair lotion, a hair cream, and the like can be prepared by mixing with various types of bases commonly known as hair cosmetics such as emulsions, creams, lotions, gels, and aerosols.

[0010] The components constituting the hair cosmetics include purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, cosmetic ingredients, ultraviolet absorbers, thickeners,
It can be appropriately selected from pigments, preservatives, fragrances, and other commonly used cosmetics as long as the effects of the present invention are not impaired.

Further, vasodilators, female hormones, skin function enhancers, local stimulants, keratolytics, anti-inflammatory agents, vitamins, which are generally known as medicinal agents for hair cosmetics,
Nourish amino acids, herbal extracts, moisturizers, etc. as needed.
You may mix | blend in expectation of a hair-growth effect more.

[0012]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

REFERENCE EXAMPLE 1 Preparation of Ginkgo Extract Extract 10 kg of a water-acetone mixture (1: 1) was added to 1.0 kg of the dried pulverized ginkgo green leaves, and extracted at room temperature for 3 days. Thereafter, the residue was again subjected to a water-acetone mixture (1:
1) Extraction was performed with 10 l at room temperature for one week, and the obtained extract was combined with the previous extract and concentrated to dryness at 50 ° C. or lower. 200 ml of 50 v / v% ethanol was added thereto, and the mixture was stirred. The insoluble matter was separated by filtration, and then applied to a Diaion HP-20 (Mitsubishi Chemical) column (500 ml). 2500 ml of water,
Washing was performed by flowing 2500 ml of 30 v / v% ethanol to remove highly polar compounds.
The fraction eluted with 500 ml was collected and concentrated to dryness to obtain a ginkgo extract.

Reference Example 2 Production of Ginkgo biloba extract Dried ginkgo biloba green leaf was added to 1.0 kg of 50 v / v
10 liters of ethanol and refluxed at 60 ° C. for 5 hours.
Time extracted. Thereafter, 10 l of 50 v / v% ethanol was again added to the residue, and the mixture was extracted at 60 ° C. under reflux for 5 hours.
The obtained extract was combined with the previous extract and concentrated to dryness at 50 ° C. or lower. Add 200ml of 50v / v% ethanol to this
Then, 200 ml of hexane was added, and the mixture was stirred, and then the hexane layer was removed. The remaining aqueous ethanol layer was concentrated to dryness at 50 ° C. or less, and this was mixed with a water-acetone mixture (1: 1) 10
The mixture was dissolved in 0 ml, and 100 ml of methyl ethyl ketone was further added. The acetone-methyl ethyl ketone layer formed after mixing was separated and concentrated to dryness to obtain a ginkgo extract.

The obtained Ginkgo biloba extract was hydrolyzed under acidic conditions, and this was used as a sample solution to determine the total flavonoids by liquid chromatography. That is, as a result of calculating the total flavonoids from the peak areas of the chromatograms using quercetin and kaempferol as standard substances, about 32.3% in Reference Example 1 and about 22.3% in Reference Example 2.
9%.

The total terpenoids were determined by liquid chromatography using a sample solution obtained by extracting the ginkgo extract with ether under acidic conditions. That is, as a result of calculating the total terpenoids from the peak areas of the chromatograms using bilobaloid and ginkgolides A, B, and C as standard substances, it was found to be about 8.7% in Reference Example 1 and about 5.2% in Reference Example 2.

Test Example 1 Test of hair growth effect Male C3H mice (8-week-old) were grouped into 10 mice, and the method of Ogawa et al. Was used (Nisshin Gakkai: 96 (3), 195-197, 1).
986), and the test was performed. That is, about 2 × 4 cm of the back of the mouse was shaved, and once a day from the next day, Table 1
Was applied every day, and the hair regeneration score was determined over time. As shown in Table 2, the hair regeneration score is the sum of the hair regeneration area score and the state score of the reproduced portion, and the score is 10 when the regeneration rate is 100%. The results are shown in Table 1.

[0018]

[Table 1]

[0019]

[Table 2]

As shown in the results of Table 1, those containing the ginkgo biloba extract promoted mouse hair regrowth and showed excellent hair growth compared to the solvent control and the crude ginkgo biloba extract preparation.
It was revealed that it has a hair growth effect.

Example 1 Hair lotion type hair restorer: A lotion was prepared according to the composition shown in Table 3 and the following method, and its hair restorer effect was examined.

(Composition and results)

[Table 3]

(Production method) A. Mix components (1) to (5).

(Test Method) A usage test was conducted in which 10 subjects were grouped as one group and the sample was applied to the head. The use period was 16 weeks, during which time subjects were required to wash their hair daily and apply the appropriate amount of sample to the scalp. In order to reduce the measurement error in the number of hair loss measurements, hair wash was instructed every day from two weeks before the use test was started, and the number of hair loss during hair wash was counted every other day from one week before. The average value of the total of three measurements was taken as the number of hair loss before application. At the end of the application period, two weeks before that, instructions were given to perform hair washing in the same manner as in the measurement before application, the number of hair loss was counted, and the average value of the total of three measurements was taken as the number of hair loss after application. The number of hair removal before application and the number of hair removal at the end of the application period were compared, and the hair removal prevention effect was defined as the hair growth effect.

Hair Restoring Effect: [Evaluation] [Contents] Effective 60% or more of test subjects 'hair loss was reduced by 20 or more. Slightly effective 60% or more subjects' hair loss was reduced by 10 or more. Less than 60% of subjects decreased

As shown in the results in Table 3, when the ginkgo biloba extract was blended, the ratio of hair loss was significantly larger than that of the comparative product 1 containing the crude ginkgo biloba extract and the comparative product 2 containing the solvent control. It was revealed that it has excellent hair-growth and hair-growth effects.

Example 2 Aerosol type hair tonic: A hair tonic was prepared according to the following formulation and the following method. (Prescription) (%) (1) Ginkgo extract * 1 5.0 (2) Isopropylmethylphenol 0.1 (3) Menthol 0.1 (4) Ethanol 40.0 (5) Perfume appropriate amount (6) Purified water Remaining amount * 1 Manufactured in Reference Example 1

(Production method) A. Components (1) to (6) are mixed. Fill aerosol container with propellant.

The aerosol-type hair tonic of Example 2 exhibited excellent hair-growth and hair-growth effects when applied to the scalp.

Example 3 Hair Cream A hair cream was prepared according to the following formulation and the following method. (Formulation) (%) (1) Ginkgo extract * 1 0.01 (2) Beeswax 1.0 (3) Liquid paraffin 50.0 (4) Stearic acid 3.0 (5) Sorbitan sesquioleate 2.2 (6) Polyoxyethylene sorbitan monolaurate 1.8 (20EO) (7) dl-α-tocopherol acetate 0.2 (8) Perfume appropriate amount (9) Methyl parahydroxybenzoate 0.1 (10) Purified water Remaining amount * 1 Manufactured in Reference Example 2

(Production method) A. The components (1) to (7) are heated and dissolved at 70 ° C. B. The components (9) and (10) are heated and dissolved at 70 ° C. C. Add A to B and emulsify. D. Add (8) to C and cool to obtain a hair cream.

The hair cream of Example 3 exhibited excellent hair-growth and hair-growth effects when applied to the scalp.

[0033]

As described above, the hair cosmetic composition of the present invention has an effective hair regeneration promoting effect and an effect of preventing hair loss. In other words, it is excellent in hair growth and hair growth effects that enhance and normalize the functions of the hair and scalp, and are extremely useful in beauty and medicine.

Claims (1)

[Claims] 1. A hair cosmetic comprising a ginkgo biloba extract having a total flavonoid content of 15 to 40% by weight and a total terpenoid content of 2 to 15% by weight as a hair restoration component.