JP2007204426A - Hair growth promoter - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair growth promoter having excellent hair-growing, hair-nourishing, hair loss-preventing and dandruff-preventing actions on alopecia. <P>SOLUTION: The hair growth promoter contains a peripheral blood flow promoting agent such as γ-aminobutyric acid derivative, nicotinic acids, vitamin E compounds, trans-3,4'-dimethyl-3-hydroxyflavanone and 6-benzylaminopurine, and a coenzyme such as coenzyme Q10 and α-lipoic acid. The invention further provides a hair growth promoter containing an extract of Reishi fungus or Ligusticum acutilobum in addition to the above components. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a hair growth material, and more particularly, to a hair growth material excellent in effects such as hair growth, hair growth, hair loss prevention, and anti-dandruff. The hair restorer of the present invention is specifically used in the field of pharmaceuticals, quasi drugs or cosmetics.

  In general, alopecia is thought to be caused by complex intertwining of various factors such as poor blood circulation, decreased hair matrix activity, and sex hormone imbalance. Especially in modern society, aging society and stress society As said, there are many opportunities to be at risk of hair loss due to various causes. However, the mechanism and mechanism of hair loss have not been fully elucidated yet. As a medicinal ingredient expected to have a hair-growth effect in conventional hair-growth materials, for example, red pepper tincture, assembly extract, ginseng extract, nicotinic acid derivative and other scalp blood circulation promoting substances, cephalanthin and other skin function enhancing substances, acetylcholine derivatives and the like Vascular dilators, female hormone agents such as estradiol, melanin synthesis catalyst agents such as pantothenic acid derivatives, keratolytic agents such as salicylic acid and resorcin, and anti-inflammatory agents such as glycyrrhetinic acid and azulene are combined to prevent and treat hair loss. It is used (for example, refer nonpatent literature 1). However, these ingredients have the effect of adjusting the hair growth environment of the scalp and improving the growth rate of hair that has already grown, but have a weak hair growth action and may cause skin irritation in some cases. Therefore, there is a limit to the amount of blending, and it has not yet reached a sufficient effect. In hair restorations, it is also important to promote the generation of new hair, and hair growth preparations containing minoxidil as a hair growth promoting substance (for example, see Patent Documents 1 and 2) have been reported. This is an application of a lowering action, and has side effects and is concerned from the viewpoint of safety. Further, although hair growth agents containing coenzyme Q10 (see, for example, Patent Documents 3 and 4) have been reported, it cannot be said that the hair growth / hair growth effect is sufficient, and therefore hair growth. There is a strong demand for a more effective hair restorer that has both an effect and a hair nourishing effect.

Tajima Masahiro “Current Status and Challenges of Hair Growth Agents” Fragrance Journal, May 1997, p. 43-51 Japanese Patent Laid-Open No. 5-4908 JP-A-7-53338 Japanese Patent No. 2969179 JP 2002-332217 A

  An object of the present invention is to provide a hair-growth agent having an effect of hair growth, hair growth, hair loss prevention and anti-dandruff which is excellent against alopecia.

That is, the invention of claim 1 of the present invention is a hair restorer containing a peripheral blood flow promoter and a coenzyme, and the invention of claim 2 is characterized in that the peripheral blood flow promoter is γ-amino. Butyric acid derivatives, nicotinic acids, vitamin E, trans-3,4'-dimethyl-3-hydroxyflavanone, 6
The hair growth material according to claim 1, which is at least one selected from the group consisting of -benzylaminopurine, and the invention according to claim 3 contains one or more coenzymes selected from coenzyme Q10 or α-lipoic acid. It is hair restorer.

  As a result of intensive studies to achieve the above object, the present inventor has obtained a peripheral blood flow promoter such as a γ-aminobutyric acid derivative and nicotinic acid, and a coenzyme such as coenzyme Q10 and α-lipoic acid. In combination, more preferably, by blending an extract extracted from litchi and spruce, it exhibits an effect of promoting hair growth and promoting hair growth, and also has a significant effect on hair loss inhibiting effect and anti-dandruff preventing effect. As a result, the present invention has been completed.

  Hereinafter, embodiments of the present invention will be described in detail.

  The hair restorer according to the present invention contains a peripheral blood flow promoter as the first essential component. Peripheral blood flow promoters include diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, nicotinic acids, minoxidil, hinokitiol, vitamin E, capronium chloride, garlic iodide extract, camphor, nonyl acid vanillylamide, glyceryl pentadecanoate, trans -3,4'-dimethyl-3-hydroxyflavanone, 6-benzylaminopurine, Ginkgo biloba extract, Hypericum herb extract, Pepper tincture, Cantalis tincture and the like. Among these, diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, nicotinic acids, vitamin Es, trans-3,4'-dimethyl-3-hydroxyflavanone, and 6-benzylaminopurine are preferable.

  Examples of γ-aminobutyric acid derivatives include γ-aminobutyric acid and γ-amino-β-hydroxybutyric acid, which are known as brain metabolism-related substances and are currently commercially available. Pharmaceutical Co., Ltd.) and Visamine (Kaken Pharmaceutical Co., Ltd.). Examples of nicotinic acids include benzyl nicotinate, tocopherol nicotinate, β-butoxyethyl nicotinate, nicotinic acid amide, nicotinic alcohol tartrate, etc., and these nicotinic acids are those currently on the market. be able to.

  Examples of vitamin E include α-tocopherol, DL-α-tocopherol acetate, tocopherol nicotinate, natural vitamin E, and the like. These vitamin Es are currently commercially available, and include E-mix D (manufactured by Iwase Kosfa), RIKEN E Acetate α (manufactured by RIKEN VITAMINS), and d-α-tocopherol acetate (manufactured by Sasaki Chemical Co., Ltd.). In addition, it can be manufactured by a known manufacturing method. Trans-3,4′-dimethyl-3-hydroxyflavanone and 6-benzylaminopurine are currently commercially available and can be produced by known production methods.

  In the present invention, one or more of these peripheral blood flow promoters can be appropriately selected and used. The blending amount of these peripheral blood flow promoters is usually 0.001 to 10.0% by mass (hereinafter referred to as%), preferably 0.02 to 3.0%, based on the total amount of hair restorer. It is. If the blending amount of the blood flow promoter is less than 0.001%, sufficient effects may not be exhibited. If it exceeds 10.0%, skin irritation may occur, which is a problem from the viewpoint of safety. May occur, which is not preferable.

A coenzyme is blended as a second essential component in the hair restorer according to the present invention. As coenzymes, adenosine triphosphate, cotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, flavin adenine dinucleotide, coenzyme A, α-lipoic acid, thiamine pyrophosphate, pyridoxal phosphate, tetrahydrofolate, UDP glucose Coenzyme Q10, biotin, coenzyme B12, S-adenosylmethionine and the like are preferably used. More preferably, one or more coenzymes selected from coenzyme Q10 or α-lipoic acid are blended.

  A preferable blending amount of these coenzymes is 0.0001 to 1%, more preferably 0.001 to 0.5% in the hair growth material of the present invention. If it is less than 0.0001%, the effect of the present invention may not be exhibited even if it is blended. If it exceeds 1%, strong coloring and low-temperature starch may occur, which is not preferable.

  Moreover, the hair restorer of this invention can exhibit the more outstanding effect by mix | blending the extract extracted from a lychee and spruce as a 3rd component. As an extract extracted from litchi and spruce, a water-soluble extract extracted in a solvent such as water or 1,3-butylene glycol is preferable. For example, litchi extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.), Sue Hill Liquid B (manufactured by Ichimaru Falcos) and the like.

  The preferable compounding quantity of the extract extracted from these litchi and spruce is 0.0001 to 1% in the hair restorer of this invention, More preferably, it is 0.001 to 0.5%. If it is less than 0.0001%, the effect of the present invention may not be exhibited even if it is blended. If it exceeds 1%, strong coloring and low-temperature starch may occur, which is not preferable.

  The hair restorer of the present invention can be used in various forms, for example, blended into a dosage form to be applied directly to the scalp such as hair tonic, hair lotion, hair cream, shampoo, rinse, hair foam, hair gel, aerosol, etc. Can be produced according to a conventional method.

  In addition to the above-mentioned components, the hair-care product of the present invention includes various components that are generally used in cosmetics, quasi-drugs, pharmaceuticals, etc. as necessary and within a range that does not impair the effects of the present invention. , For example, oil, moisturizer, thickener, dye, fragrance, bactericidal agent, antiseptic, UV absorber, solvent, water, keratolytic agent, anti-inflammatory agent, anti-androgen agent, hair restorer, antioxidant, refreshing Agents, herbal extracts, vitamins and the like can be appropriately blended.

  EXAMPLES Hereinafter, although an Example demonstrates this invention concretely, the technical scope of this invention is not limited by these Examples. In addition, the test method regarding the hair papillary cell proliferation promotion effect test, the hair growth promotion effect test, the hair loss prevention effect test, and the anti-dandruff effect test described in Examples is shown below.

(1) Test method for promoting proliferation of dermal papilla cells 2 × 10 ⁴ cells per well of cultured dermal papilla cells in a 24-well plate, preincubated for 24 hours in a CO ₂ incubator at 37 ° C., and 1 mL test sample Was added and preincubated for 24 hours. To these, 1 mL of a test sample containing 0.5 μCi of ³ H-thydimine per well was added and incubated for 6 hours. Thereafter, the cells were washed twice, 10% TCA was added, allowed to stand at 4 ° C. for 10 minutes, TCA was then removed, alkali hydrolysis with sodium hydroxide was performed, neutralized with formic acid, scintillation cocktail was added, and radiation was performed. Activity was measured and DNA synthesis levels were examined. The determination of the proliferation effect was compared with the control, and the proliferation effect was evaluated by the following formula.
Hair papilla cell proliferation promoting effect = (B) / (A)
(A): Effect of control (Comparative Example 1) on proliferation of dermal papilla cells (dpm / 10 ⁴ cells)
(B): Hair papillary cell proliferation promoting effect (dpm / 10 ⁴ cells) in the samples of Examples and Comparative Examples
Note: dpm = 1/30 Bq

(2) Human scalp hair growth promoting effect test method The head of 10 test subjects who are male pattern baldness patients, and the head hair located 5 cm above the ear in a circular shape with a diameter of 1 cm at two left and right positions. About 3 mL of each sample of Examples and Comparative Examples was applied to the left side twice daily in the morning and evening on the shaved test site, and compared with the untreated right side. On the 28th day after the start of the test, the effect was determined by shaving 20 hairs on each of the left and right test sites, and evaluating the degree of hair growth promotion with the value determined by the following formula.
Hair growth promotion level = (D) / (C)
(C): Average value of the length of 20 hairs on the right side (no treatment) (D): Average value of the length of 20 hairs on the left side (the sample of the example and the comparative example applied)

(3) Human Hair Loss Prevention Test Method The hair loss was applied to the heads of 10 test subjects who were male pattern baldness patients twice daily in the morning and evening for 4 months. The hair that was lost during shampooing was collected, the number of hairs was counted, and the number of hairs lost per day was calculated. In the fourth month after the application of the sample, hair washing was again performed by a professional beautician for 3 days, the hair that was lost during the hair washing was collected, the number of hairs was measured, and the number of hair loss per day was calculated. The hair loss prevention effect was evaluated by the value obtained by the following formula for the number of hair loss per day before the start of the test and after 4 months.
Hair loss prevention effect (%) = (F) / (E)
(E): Number of hair loss per day before application (F): Number of hair loss per day 4 months after application

(4) Anti-dandruff test method The occurrence of dandruff after application to the heads of 10 test subjects who are male pattern baldness patients twice a day for 4 months was evaluated. The test results are shown by the number of respondents who answered that “dandruff was reduced”.

Examples 1-4, Comparative Examples 1-2
A hair restoration having the formulation shown in Table 1 was prepared according to a conventional method, and the above tests were performed for evaluation. The results are also shown in Table 1.

  As is clear from Table 1, the hair-growth material of the present invention clearly has a hair papillary cell proliferation-promoting effect, hair growth-promoting effect, hair growth-promoting effect, hair loss prevention, and anti-dandruff evaluation in comparison with the comparative example. It was excellent.

  Hereinafter, the other prescription example of the hair restorer of this invention is given as an Example. In addition, for the hair growth material of the present invention of these examples, the above-described hair papilla cell proliferation promoting effect, hair growth promoting effect, hair growth promoting degree, hair loss prevention, anti-dandruff effect were examined. It had excellent characteristics and was good.

Example 5 (Tonic)
Compounding amount (%)
(1) 95% ethanol 60.0
(2) γ-amino-β-hydroxybutyric acid 0.5
(3) Benzyl nicotinate 0.01
(4) α-Lipoic acid 0.1
(5) Propylene glycol 2.0
(6) Spruce extract (Ichimaru Falcos) 0.05
(7) Fragrance 0.1
(8) Dye proper amount
(9) Purified water balance

(Manufacturing method) In (1), (2) to (5) and (7) are dissolved, and then (6) and (8) to (9) are added, and the mixture is stirred and transparent. I got a liquid tonic.

Example 6 (hair growth lotion)
Compounding amount (%)
(1) 95% ethanol 45.0
(2) dl-α-tocopherol acetate 0.05
(3) 6-benzylaminopurine 0.5
(4) Benzyl nicotinate 0.01
(5) α-Lipoic acid 0.1
(6) Coenzyme Q10 0.003
(7) Menthol JP (manufactured by Takasago International Corporation) 0.3
(8) D-pantothenyl alcohol 0.4
(9) Isopropylmethylphenol 0.2
(10) Hydrogenated bisabolol 0.2
(11) Dipropylene glycol 2.0
(12) Polyoxyethylene (80) hydrogenated castor oil 0.5
(13) Edetate tetrasodium 0.02
(14) L-serine 0.1
(15) L-threonine 0.1
(16) Ganoderma Extract (Maruzen Pharmaceutical Co., Ltd.) 0.3
(17) Balance of purified water

(Production Method) (2) to (11) were dissolved in (1). Subsequently, it mixed and stirred with what dissolved (12)-(16) in (17), and obtained the transparent liquid hair growth lotion.

Example 7 (aerosol hair restorer)
Compounding amount (%)
<Undiluted solution formulation>
(1) 95% ethanol 80.0
(2) Trans-3,4'-dimethyl
-3-Hydroxyflavanone 0.5
(3) γ-amino-β-hydroxybutyric acid 0.5
(4) Adenosine triphosphate 0.05
(5) Sodium lauryl sulfate 0.1
(6) Polyoxyethylene (60) hydrogenated castor oil 0.5
(7) Salicylic acid 0.1
(8) Sodium lactate 0.05
(9) Spruce extract (Maruzen Pharmaceutical Co., Ltd.) 0.05
(10) Ganoderma extract (Ichimaru Falcos) 0.05
(11) Fragrance 0.2
(12) Dye amount
(13) Balance of purified water
<Filling prescription>
(14) Stock solution 50.0
(15) Liquefied petroleum gas 50.0

(Manufacturing method) Each component of the stock solution formulation was mixed and dissolved to prepare a stock solution, which was filled in a can. After mounting the valve, liquefied petroleum gas was filled to prepare an aerosol hair restorer.

Example 8 (Emulsion type hair restorer)
Compounding amount (%)
(1) Isopropyl isostearate 3.0
(2) Carboxyvinyl polymer (Syntalne K; manufactured by Wako Pure Chemical Industries, Ltd.) 0.3
(3) Carboxyvinyl polymer (Syntalne L; manufactured by Wako Pure Chemical Industries, Ltd.) 0.3
(4) 6-benzylaminopurine 0.2
(5) dl-α-tocopherol acetate 0.4
(6) Coenzyme Q10 0.03
(7) Carrot extract (Maruzen Pharmaceutical Co., Ltd.) 1.0
(8) L-menthol 0.2
(9) Isopropylmethylphenol 0.1
(10) Hydrogenated bisabolol 0.5
(11) Squalane 0.1
(12) Triethanolamine 0.5
(13) Murasaki assembly extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0
(14) Ganoderma extract (Ichimaru Falcos) 0.5
(15) Spruce extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(16) VC-SS (manufactured by Nippon Surfactant) 0.01
(17) L-serine 0.1
(18) L-threonine 0.1
(19) N-acetyl-DL-methionine 0.1
(20) Fish-derived hydrolyzed collagen solution 0.5
(21) Ethanol 10.0
(22) Polyoxyethylene hydrogenated castor oil (60 EO) 0.5
(23) Disodium edetate 0.1
(24) Fragrance 0.2
(25) Balance of purified water

(Production method) (1), (4) to (12), (22), (24) are added to (21), and after stirring and dissolving, (2) to (3), (13) are added to (25). -(20), (23) was added, and what was stirred and dissolved was added to obtain an emulsion type hair restorer.

In addition, the fragrance | flavor used in the said Example is the following.

  As described above, it is apparent that the present invention can provide a hair-growth material having effects such as hair growth, hair growth, hair loss prevention, and anti-dandruff which are excellent for alopecia.

Claims (4)

A hair restorer comprising a peripheral blood flow promoter and a coenzyme. The peripheral blood flow promoting agent is at least one selected from the group consisting of γ-aminobutyric acid derivatives, nicotinic acids, vitamin Es, trans-3,4'-dimethyl-3-hydroxyflavanone and 6-benzylaminopurine. The hair restorer according to claim 1. 3. The hair restorer according to claim 1 or 2, wherein the coenzyme is blended with at least one selected from coenzyme Q10 and α-lipoic acid. Furthermore, 1 or more types of extract extracted from litchi and spruce is mix | blended, The hair restorer in any one of Claims 1-3 characterized by the above-mentioned.