JP2001181172A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic excellent in skin beautifying effects due to an improvement in dry feeling, skin roughening, etc., for the skin, and further, excellent in hair producing and hair growing effects such as hair producing and hair growth promotion for the hair of the head and having safety for sufficiently enabling the cosmetic to endure the use over a long period. SOLUTION: This cosmetic is produced by carrying out extraction of a plant body of Pavonia Schiedeana with preferably a water-soluble organic solvent or a hydrous organic solvent and formulating the resultant extracts from the Pavonia Schiedeana.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more particularly to cosmetics, which are excellent in skin-beautifying effects by improving dryness and rough skin on the skin. -It is intended to provide cosmetics having an excellent hair-growth effect.

[0002]

2. Description of the Related Art Various herbal extracts have been blended into cosmetics. For example, in skin cosmetics, placenta extract, extract such as yoquinin, gougon, bukuro, etc. (JP-A 57-31604, JP-A 59-73509, Japanese Patent Application Laid-Open (JP-A) No. 60-78910 and the like, and extracts for hair growth and hair growth, such as yoquinin and cashew, for the purpose of hair-growth effect (Japanese Patent Publication No. 1-13451, JP-A-2-48514). See)).

[0003]

However, as mentioned in the above examples, various herbal extracts have been applied to the cosmetics provided so far, but few of them show a remarkable effect. In addition, those having a certain effect have such drawbacks that they are so irritating that dermatitis is caused and that continuous use is difficult.

[0004] The present invention has been made in view of such circumstances, and is excellent in the skin beautiful effect by improving the dry feeling, rough skin, etc. on the skin.
It is an object of the present invention to provide a cosmetic composition which is excellent in hair growth and hair growth effects such as hair growth promotion and has sufficient safety for long-term use.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, an extract obtained from a specific plant belonging to the Malvaceae family has an excellent skin beautiful effect on the skin. On the other hand, they have found that they have excellent hair growth and hair growth effects on the hair and that there is no safety problem during use, and have completed the present invention based on such findings.

[0006] That is, the present invention relates to an extract obtained by extracting a plant of Pavonia Schiedeana with a water-soluble organic solvent or a water-soluble water-soluble organic solvent, preferably from 0.001 to 10%. It relates to a cosmetic characterized in that it is contained in the range of weight%. In addition, the present invention relates to a cosmetic preferably further containing a peripheral blood flow promoting agent. Further, the cosmetic of the present invention is suitable as a hair growth / hair restoration.

Hereinafter, the present invention will be described in detail.

First, Pavonia Schiedeana applied to the present invention is a herb or shrub belonging to the genus Pavonia, which is widely distributed in Central and South America. Until now, Pavonia Squideana has been cultivated mainly for horticulture, and this plant has never been applied practically from an external point of view, and it has a beautiful skin effect on the skin and a hair growth and hair growth effect on the hair. Has been found for the first time by the present inventors.

[0009] Since the above-mentioned plant of Pavonia squideana contains a component that activates the original function of the skin, when the Pavonia squidea extract is blended with a cosmetic, it has an excellent skin effect and hair growth. A cosmetic having a hair-growth effect can be obtained. In addition, the said beautiful skin means that the skin in a defective state such as dry skin or rough skin is improved to the extent that it can be confirmed from the appearance. Further, the above-mentioned hair growth / hair growth refers to a state where hair is growing, for example, hair growth for newly growing hair, growing hair growing, or maintaining a state where hair is growing. The concept includes hair growth and the like, and it is sufficient that at least one of the above-described hair growth and hair growth is exhibited.

Next, in order to obtain the extract according to the present invention from the above-mentioned Pavonia skideana, the whole tissue constituting the plant or each part of the plant which is a part thereof, preferably the stem, leaves or whole plant, is dried. Or as it is, pulverized, and extracted with an extraction solvent such as a monohydric alcohol such as methanol, ethanol, propanol or butanol, a polyhydric alcohol such as 1,3-butylene glycol or propylene glycol, or an aqueous solution such as acetone, tetrahydrofuran or dioxane. Water-soluble organic solvents, preferably containing at least 50% by weight of the above-mentioned monohydric alcohols, polyhydric alcohols, acetone, tetrahydrofuran, dioxane and the like, and also water-insoluble solvents such as hexane, heptane, cyclohexane and ethyl acetate. Extract with an organic solvent, preferably aqueous Good to use organic solvents or water-soluble organic solvent.

As a specific method for obtaining the cosmetic according to the present invention, for example, 100 g of Pavonia skideana is
Using 0.5 to 5 L of the extraction solvent, at room temperature to the boiling point of the extraction solvent, at room temperature for 4 to 10 days, at heating for 4 to 8 hours,
Extract by digestion twice. These extracts are combined, filtered with suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous or dried extract. The obtained extract is dissolved or dispersed or diluted with an appropriate solvent or the like as it is, and then mixed with a base to obtain the cosmetic of the present invention.

[0012] Here, the content of the Pavonia squidiana extract according to the present invention is preferably 0.001 to 10% by weight, particularly preferably 0.01 to 5% by weight based on the total amount of the cosmetic.
% By weight. If the content is less than 0.001% by weight, the effects intended in the present invention are not sufficiently exhibited, and if the content exceeds 10% by weight, the stability of the cosmetic may be reduced depending on the dosage form.

Next, when the cosmetic of the present invention is used as a hair growth and hair growth agent, a more preferable hair growth and hair growth effect can be obtained by adding a peripheral vascular blood flow promoter in addition to the above-mentioned Pavonia skidiana extract. Have. In addition, the peripheral blood flow promoter is
It may be a substance that has the effect of promoting blood flow in peripheral blood vessels by expanding the blood vessel wall, or may strengthen the blood vessel wall by suppressing the generation of lipids and the like that deteriorate blood flow in peripheral blood vessels, thereby strengthening the original blood vessel. It may be a substance that restores vasomotor function. Such peripheral blood flow promoters include:
Examples thereof include carpronium chloride, benzyl nicotinate, vitamin E, vitamin E acetate, vitamin E linoleate, vitamin E nicotinate, pepper tincture, and the like, and one or more of these are used.

In addition, the cosmetic of the present invention may be used, if necessary, in ordinary skin cosmetics and hair growth / hair restoration in addition to the above-mentioned Pavonia squideana extract and peripheral blood flow promoter. Various components and additives such as inorganic pigments, organic pigments, inorganic powders, organic powders, hydrocarbons, waxes, fats and oils, esters, higher fatty acids, higher alcohols, triglycerides, lanolins, waxes , Animal and vegetable oils,
Silicones, surfactants, polyhydric alcohols, sugars, vitamins, amino acids, cooling agents, antioxidants, preservatives / bactericides, fragrances, thickeners, UV protection agents, alcohols, pH adjusters and Water and the like can be blended.

The cosmetic of the present invention includes various dosage forms. Examples of the skin cosmetic include a lotion, an emulsion, a cream, a pack, a foundation, a lipstick, and the like.
In addition, hair tonic, shampoo,
Rinsing, pomade, hair lotion, hair cream, hair treatment and the like can be mentioned, and are prepared according to a conventional method.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION Here, a production example of a Pavonia squidiana extract according to the present invention will be described. Production Example 1. Pavonia Ski Deana Whole Plant Dried 100
g of methanol at room temperature for 4 days, and the residue was filtered off with filter paper. The filtrate was evaporated to dryness.
An extract was obtained. (Yield 3.0%)

Production Example 2 100 g of dried whole plant of Pavonia Squideana is dried at room temperature with 2 L of 70% ethanol at room temperature.
Extraction was performed by immersion for one day, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.3%)

Production Example 3 100 g of dried leaves of Pavonia schidegana are immersed in 2 L of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.9%)

Production Example 4 100 g of dried stalks of Pavonia schideana are immersed in 2 L of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 2.6%)

Production Example 5 100 g of dried leaf of Pavonia schideana is propylene glycol: distilled water = 1: 1
Immersed in 2 L of extraction solvent, and transferred to a Soxhlet extractor.
Perform warm extraction for 8 hours. After cooling, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (1.4% yield)

Production Example 6 100 g of dried stalks of Pavonia schideana were immersed and extracted with 2 L of ethyl acetate at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract. (Yield 1.1%)

Next, the results of tests conducted to demonstrate how the cosmetics of the present invention are excellent in terms of a beautiful skin effect and hair growth and hair growth effects will be described.

1. Skin beauty effect test (1) Sample The present invention product: lotion of Example 1 described below Comparative product 1: lotion prepared by replacing Pavonia squideana extract in the lotion of Example 1 described below with placenta extract Comparative product 2: The lotion obtained by removing the Pavonia squidiana extract from the lotion of Example 1 (increase the amount of water).

(2) Test method Forty-five Japanese adult women with dry skin were randomly divided into three groups (groups A to C), each having 15 persons. The lotion of the present invention product is applied to the face of Group A, the lotion of Comparative Product 1 is applied to the face of Group B, and the lotion of Comparative Product 2 is applied to the face of Group C.
Applied for a week. A comparison was made between the groups in the state of improvement in dry feeling after 4 weeks and in the state of spontaneous deterioration (the state in which skin drying progresses despite application of the above-mentioned lotion). Also,
For evaluation of the rough skin condition, the stratum corneum was isolated from the facial skin by a tape stripping method,
According to the method described in JP-A-58-58, the stratum corneum was observed by an optical microscope, and the degree of delamination and the presence or absence of nucleated cells were evaluated in five steps. The results are shown in Tables 1 and 2.

[0025]

[Table 1]

[0026]

[Table 2]

As shown in the results of Tables 1 and 2, the lotion of the product of the present invention has a remarkable improvement in dry feeling and skin roughness as compared with the lotion of the comparative product, and has an excellent skin effect. Has been demonstrated. In addition, as an opinion other than the above evaluation factors, it was also clarified that the cosmetic of the present invention had no adverse effects on safety such as irritation and skin irritation during use.

2. Hair growth / hair growth effect test "Mouse hair growth evaluation test" (1) Sample The present invention product: 70% ethanol aqueous dispersion containing 5% of Pavonia schidegana extract (Production Example 2) Comparative product: Vitamin E 1% 70% ethanol aqueous dispersion containing: 70% ethanol aqueous solution

(2) Test method Using C3H mice of 9 weeks old, one group consisted of 10 mice, and three groups were formed. The backs of these groups were shaved to a size of 2.0 × 2.0 cm and then removed the next day. After applying 0.04 g of each sample to the hair site,
On the 20th day, the density of hair growth at the site was evaluated as a degree of black increase using a color difference meter. Table 3 shows the results.

[0030]

[Table 3]

As is evident from the results in Table 3, it can be seen that in the Pavonia squideana extract according to the present invention, the L value decreases and the blackness increases as compared with the control. On the other hand, the vitamin E of the comparative product showed only a small decrease in the L value compared to the control of the present invention. This is presumed to be the result of the Pavonia squidiana extract according to the present invention stimulating hair roots, increasing blood circulation around hair follicles, and activating metabolism.

"Human hair growth / hair growth evaluation test" (1) Sample The present invention product: Hair tonic of Examples 7 to 9 described below Comparative product: From hair tonic of Example 7 to Pavonia
Ski deana extract (Production Example 2) was removed (increased water)
Hair tonic

(2) Test Method Twenty panelists complaining of alopecia and alopecia were divided into 4 groups of 5 each, and a long-term continuous test for 6 months was performed using each sample. The application method was a method of evenly applying the composition to the head twice a day as in the usual tonic usage. The evaluation was performed on the third and sixth months after the start of use, and the degree of increase in the number of test subjects who felt that the hairs and hairs had increased was measured. In addition, at the end of the test, they were asked to improve their scalp condition and reduce dandruff. Table 4 shows the results.

[0034]

[Table 4]

As is evident from the results in Table 4, the hair growth and hair growth-promoting agent of the present invention has a hair growth and hair growth effect because the number of people who have hair growth and those who have hard hair have increased. Was observed. At the end of the test, the number of persons who reported improvement in the condition of the scalp and reduced occurrence of dandruff was 4 in Example 7 and 2 in Example 8. From this, the hair growth of the present invention
The effect of improving the condition of the scalp was also recognized in the hair restoration material. Furthermore, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the safety was high.

[0036]

Examples of the present invention will be described below. The mixing ratio is part by weight.

Embodiment 1 Lotion (A) Purified water 78.89 Glycerin 5.0 Propylene glycol 4.0 (B) POE (20) Sorbitan monolaurate 1.5 POE (20) Lauryl ether 0.5 Ethanol 10.0 Pavonia Skideana Extract (Production Example 2) 0.01 Fragrance 0.1

(Preparation method) The components of (A) are combined and dissolved at room temperature. On the other hand, each component of (B) is also dissolved at room temperature, and is added to (A) formulation and solubilized.

Embodiment 2 Emulsion (A) POE (20) hydrogenated castor oil 1.5 coconut oil fatty acid monoglyceride 1.0 oleic acid triglyceride 7.5 (B) glycerin 2.5 Pavonia schiadeana extract (Production Example 1) 1.0 Water 86.3 (C) Fragrance 0.2

(Preparation method) According to each component of (A), heat and mix to 70 ° C. Combine each component of (B) and add 7
Heat and mix at 0 ° C, add the (A) formulation to this, emulsify,
Add (C) while cooling.

Embodiment 3 FIG. Hand cream (A) Vaseline 18.0 Cetanol 8.0 POE (20) Oleyl ether 1.4 Sorbitan monostearate 0.8 (B) Preservative 0.3 Pavonia skidiana extract (Production Example 4) 5 Refined water 70.8 (C) Fragrance 0.2

(Preparation method) The same method as in Example 2 was used.

Embodiment 4 Cream (A) POE (30) Cetyl ether 2.0 Glycerin monostearate 10.0 Liquid paraffin 10.0 Vaseline 4.0 Cetanol 5.0 Preservatives 0.2 (B) Propylene glycol 10.0 Pavonia skideana Extract (Production Example 5) 2.0 Refined water 56.8

(Preparation method)
Heat to 0 ° C. Combine the components of (B) and heat to 80 ° C. While stirring the prescription of (A), the prescription of (B) is added thereto to stir and emulsify, followed by cooling.

Example 5 Packing Charge (A) Polyvinyl Alcohol 15.0 Purified Water 40.0 (B) Bisabolol 0.5 γ-Tocopherol 0.02 Ethanol 4.0 Pavonia Schiadeana Extract (Production Example 3) 0 POE (8) Polyoxypropylene glycol (55) 3.0 Refined water 33.48

(Preparation method) (A) is dispersed and dissolved at room temperature. (B) is added thereto and uniformly dissolved.

Example 6 Gel cosmetic oil (A) Sucrose fatty acid ester 5.0 (Daiichi Kogyo Seiyaku DK Ester F-160) (B) 1,3-butylene glycol 10.0 Glycerin 24.0 Purified water 4.5 Preservative 0.3 (C) Liquid paraffin 20.0 Olive oil 30.0 2-Ethylhexanoic acid triglyceride 5.0 Pavonia schidegana extract (Production Example 6) 1.0 (D) Flavor 0 2

(Preparation method)
Heat to 0-80 ° C. and dissolve (A) in this. To this, the prescription of (C) is added, and when cooled to 40 ° C., (D) is added and then cooled.

Embodiments 7 to 9 Hair tonic Using the components and composition shown in Table 5 below, each component was heated and dissolved and solubilized to prepare a hair tonic.

[0050]

[Table 5]

Embodiment 10 FIG. Hair tonic (A) Pavonia ski deana extract (Production Example 4) 3.0 Menthol 0.2 Vitamin E 0.05 Carpronium chloride 0.1 (B) Ethanol 50.0 (C) Propylene glycol 5.0 Vitamin B2 0.5 Yeast extract (containing nucleic acid) 0.5 Glycyrrhizin dipotassium 0.3 Hydrochloric acid Diphenhydramine 0.3 Methyl paraben 0.2 (D) Purified water 39.75 (E) Fragrance 0.1

(Preparation method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

Embodiment 11 FIG. Hair treatment (A) Liquid paraffin 2.0 Methyl polysiloxane (10 cs) 2.0 Cetanol 4.0 Pavonia schideana extract (Production Example 5) 4.5 (B) Stearyl trimethyl ammonium chloride 3.0 Distearyl dimethyl ammonium chloride 0.5 Propylene glycol 5.0 Pyroctone olamine 0.25 Purified water 40.0 (C) Hydrolyzed collagen 0.5 Hyaluronic acid 0.01 Bovine placenta extract 0.5 Purified water 37.19 Diphenhydramine hydrochloride 0.25 Methyl paraben 0.2 (D) Fragrance 0.1

(Production method) (A) and (B)
Heat to 0 ° C., mix and emulsify both. Then 40 ° C
After cooling to the vicinity, (C) was added at that point, and (D) was further added to prepare a hair treatment.

Embodiment 12 FIG. Hair shampoo (A) Triethanolamine lauryl sulfate 10.0 Sodium lauryl sulfate 5.0 Coconut oil diethanolamide 2.0 Propylene glycol 5.0 Piroctone olamine 0.25 Benzyl nicotinate 0.1 Pavonia squideana extract (Production example 3) 1.0 (B) Trichlorocarbanilide 0.25 Purified water 76.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed at 80 ° C., then cooled to about 40 ° C., (B) was added, and (C)
Was added to prepare a hair shampoo.

Embodiment 13 FIG. Hair rinse (A) Liquid paraffin 0.5 Methylpolysiloxane (10 cs) 0.5 Cetanol 2.0 Stearyltrimethylammonium chloride 3.0 Pavonia schideana extract (Production Example 2) 2.0 (B) 1,3-butylene glycol 5.0 Purified water 40.0 Diphenhydramine hydrochloride 0.25 (C ) Glycyrrhizin dipotassium 0.25 Purified water 46.4 (D) Fragrance 0.1

(Preparation method) (A) and (B) were
Warm to ° C., at which point mix and emulsify. Then 4
After cooling to about 0 ° C., (C) was added, and (D) was further added to prepare a hair rinse.

Embodiment 14 FIG. Hair cream (A) Pavonia ski deana extract (Production example 1) 2.5 Vaseline 7.0 Beeswax 8.0 Liquid paraffin 37.0 Polyoxyethylene (20E.O.) cetyl ether 3.0 Glyceryl monostearate 2.0 Vitamin E nicotinate 0.1 (B) Purified water 34.6 Propylene glycol 5.0 Diphenhydramine hydrochloride 0.2 Dipotassium glycyrrhizin 0.2 Ethyl paraben 0.3 (C) Fragrance 0.1

(Preparation method) (A) was mixed and dissolved at 80 ° C.
Next, (B) previously heated to 80 ° C. was gradually added to (A) to form a cream. Then cool down to 40 ° C,
(C) was added to prepare a hair cream.

Embodiment 15 FIG. Hair tonic (A) Pavonia ski deana extract (Production Example 6) 0.5 Salicylic acid 0.3 Menthol 0.2 Pepper tincture 0.01 (B) Ethanol 60.0 (C) Glycerin 5.0 (D) Purified water 33.89 (E) Fragrance 0.1

(Preparation method) (A) is dissolved in (B),
To this was added (D) and (E) in which (C) was dissolved to prepare a hair tonic.

The hair growth and hair growth effects of the present invention obtained in Examples 10 to 15 were tested for hair growth and hair growth effects in the same manner as in Examples 7 to 9, and all were excellent. No skin damage such as deterioration of the scalp condition and inflammatory reaction was observed at all.

[0064]

According to the present invention, of course, the beautiful skin effect such as improvement of skin condition such as rough skin is remarkably superior to conventionally known skin roughening agents and the like.
It is possible to use cosmetics that have excellent hair growth and hair growth effects, do not cause skin damage due to long-term continuous use, and have no adverse effects on safety.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) // A61K 7/075 A61K 7/075 7/08 7/08 (72) Inventor Takuya Yamamoto Yokohama, Kanagawa Prefecture 560 Kashio-cho, Totsuka-ku, Toura Research Laboratories, Ltd. (72) Inventor Mayumi Shishido 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture, Japan 1144 Togo, Mobara-shi Mitsui Chemicals Co., Ltd. In-house (72) Inventor Satoshi Yoshitani 1144, Togo, Mobara-shi, Chiba Prefecture Mitsui Chemicals In-house Terms (reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AC012 AC022 AC072 AC102 AC122 AC182 AC422 AC432 AC442 AC472 AC482 AC552 AC642 AC692 AC782 AC812 A C852 AD112 AD152 AD222 AD332 AD432 AD532 AD632 AD662 BB51 CC01 CC04 CC05 CC06 CC07 CC32 CC37 CC38 CC39 DD23 DD30 DD31 DD38 DD41 EE12 EE22 FF05

Claims (5)

[Claims] 1. Pavonia Schie
A cosmetic composition comprising an extract of a plant of the present invention. 2. The cosmetic according to claim 1, wherein the extract is extracted from the plant with a water-soluble organic solvent or a water-containing water-soluble organic solvent. 3. The content of the extract is from 0.001 to 10
The cosmetic according to any one of claims 1 and 2, which is in terms of% by weight. 4. The cosmetic according to claim 1, wherein the cosmetic is a hair growth / hair restoration. 5. The cosmetic according to claim 4, further comprising a peripheral blood flow promoting agent.