JP2000007534A - Composition for skin of scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for skin of scalp and hair having excellent trichogenous effect, depilation inhibiting effect and scurf and pruritus inhibiting effect and safety by including decyltetradecyldimethylamine oxide and a specific inhibitor. SOLUTION: This composition preferably includes (A) 0.001 to 20 wt.%. (based on whole composition) of the decyltetradecyldimethylamine oxide and (B) 0.001 to 10% of the testostrone 5α reductase inhibitor. The preferable component (B) is solvent extracted vegetable extracts of one or more kinds of plants selected from Gambir, Foeniculm vulgare Miller, Glycyrrbiza glabra hinne, etc., or oxendolone, or Finasteride and the compound expressed in the formula such as 2-decyltetradecyldimethylamine oxide or the like is preferably used as the component (A).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composition for scalp hair. More specifically, the present invention relates to a composition for scalp hair which has an excellent hair-growing effect, an anti-hair loss effect and an anti-dandruff / kayumi effect, and is excellent in safety.

[0002]

2. Description of the Related Art There are various types of scalp hair compositions, and products corresponding to various scalp hair conditions are hair cosmetics,
It has been developed as a hair restorer and the like. For example, products have been developed that prevent hair loss by preventing dandruff and Kayumi on the scalp.

[0003] In today's aging society, various troubles on the scalp are increasing along with an increase in social stress, and the demand for scalp hair cosmetics corresponding to troubles on the scalp is rapidly increasing.

In general, baldness and alopecia of the head, thinning of hair, dandruff and kayumi of the scalp are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, and production of lipid peroxide. And a decrease in blood flow to the hair follicle and stress.

[0005] In addition, when sufficient nutrition is not supplied to hair follicles for growing durable and beautiful hair, fine hair and thin hair may be caused. Also, a decrease in blood flow to the hair follicle results in a lack of nutrition and a reduced function of excreting waste products.

[0006] From such a point of view, improving turnover of the stratum corneum and excessive sebum secretion in the scalp solves at least a decrease in blood flow function in the scalp and solves problems in the scalp and hair. It is an indispensable point on the top.

[0007] Conventional scalp hair compositions generally contain a substance having an action of removing or reducing the factors considered to be the cause of baldness and hair loss. For example,
Vitamins such as vitamin B and vitamin E; amino acids such as serine and methionine; assembly extracts; vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as purple root extract;
Hormonal preparations for women such as estradiol, skin function enhancers such as cepharanthin, etc. are blended and used for prevention and treatment of baldness, hair loss and hair thinning.

[0008]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the composition for scalp and hair. There is a problem in that the compounding amount is limited due to an increased tendency to accompany the irritating feeling and redness, and the desired effect cannot always be sufficiently obtained.

The present inventors have conducted intensive studies in view of the above viewpoints, and as a result, by combining decyltetradecyldimethylamine oxide with a testosterone 5α reductase inhibitor, an excellent hair-growth effect and a hair loss-preventing effect were obtained. The present inventors have found that a composition for scalp hair which has an effect of preventing dandruff and kayumi on the scalp and is also excellent in safety can be obtained, thereby completing the present invention.

An object of the present invention is to provide a composition for scalp hair which has an excellent hair-growing effect, an effect of preventing hair loss, an effect of preventing dandruff and swelling of the scalp and is also excellent in safety.

[0011]

That is, the present invention provides a composition for scalp hair comprising decyltetradecyldimethylamine oxide and a testosterone 5α reductase inhibitor.

The present invention also relates to the testosterone 5α.
Reductase inhibitors are used as Asenyaku, Atikoria, Yerbarisa, Yew, Intin, Woro, Fennel,
Usbenioi, Agetsu, Ortiganigra, Onji, Kagosou, Kakocha, Kashuu, Cuckoo Thistle,
Valerian, guarana, cardosanto, licorice, catalpa, calendula, chinensis, scallop, kengoshi,
Gennoshoko, Quacharate, Kusanaw, Kumaseba, Gobishi, Goboushi, Coriander, honey locust,
Psycho, Sanshishi, Sansho, Peony, Shazenshi, Jankan, Jouzan, Sedron, Senso, Sokuhakuyou, Soyou, Daio, Down Trawas, Chankapiedra, Chowji, Nigaki, Areca, Machiko,
Mokka, Yakumoso, Yamahagi, Yokuinin, Legro,
Rosin, a solvent-extracted extract of one or more plants selected from the group consisting of cotton, oxendrone, or
It is intended to provide the above composition for scalp hair, which is finasteride.

Further, the present invention provides the composition for scalp hair, wherein the content of the decyltetradecyldimethylamine oxide is 0.0001 to 20% by weight based on the total amount of the composition for scalp hair. It provides things.

The present invention also relates to the testosterone 5α.
The present invention provides the composition for scalp hair, wherein the content of the reductase inhibitor is 0.001 to 10% by weight based on the total amount of the composition for scalp hair.

[0015]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The decyltetradecyldimethylamine oxide used in the present invention is a known compound. For example, 2-decyltetradecyldimethylamine oxide represented by the following chemical formula is preferably used.

Embedded image

The testosterone 5α reductase inhibitor used in the present invention is a substance which suppresses the action of testosterone 5α reductase on testosterone. The preferred testosterone 5α reductase inhibitor in the present invention is senayak, atikoria, yervalisa, yew, intin, wool , Fennel, usbania oyster, age, oltiganigra, onji, kagosou,
Kakocha, Kashuu, Cuckoo Thistle, Antelope, Guarana, Cardosanto, Licorice, Catalpa, Calendula, Kinmokusei, Kaigai, Kengoshi, Gennoshoko, Kucharararate, Kusananou, Kumaseba, Gobishi, Goboushi, Coriander, Saikashi, Sashio, Sashio, Saiko, Sashio Shazenshi, Jankan, Jouzan, Cedron, Senso, Sokuhakuyou, Soyou, Daioh, Down Trawas, Chankapiedra,
It is a solvent-extracted extract, oxendrone, or finasteride of one or more plants selected from the group consisting of clove, nigaki, areca, machiko, mocca, yam moth, yamahagi, yokunin, reglo, rosin, and cotton.

The above-mentioned solvent-extracted plant extract is an extract with water or an organic solvent, for example, a dry powder or a non-dried powder of the above-mentioned plant, flower, seed, fruit, leaf, root or whole plant. The cut material is heated with water, methanol, ethanol, propylene glycol, 1,3-butylene glycol, butanol, chloroform, dichloroethane, carbon tetrachloride, ethyl acetate, or an ether or a mixture thereof at a temperature of 30 to 70 ° C. Extract with stirring for 1 to 10 hours, or extract for 1 to 20 days at room temperature, filter,
The filtrate may be concentrated, and further concentrated under reduced pressure to dryness. In the present invention, it can be used at the stage of a concentrated solution or at the stage of a dried product.

The content of decyltetradecyldimethylamine oxide is 0.00% based on the total amount of the scalp hair composition.
0.01 to 20% by weight, preferably 0.05% to 5%.
% By weight. If the amount is less than 0.0001% by weight, sufficient hair-growth effect, hair loss preventing effect and scalp dandruff / kayumi preventing effect cannot be obtained. If it exceeds 20% by weight, unpleasant sticky or irritating feeling is imparted to the upper scalp when used. .

The amount of the testosterone 5α reductase inhibitor is 0.0 to the total amount of the scalp hair composition.
It is 0.01 to 5% by weight, preferably 0.01% to 5% by weight. If the amount is less than 0.0001% by weight, sufficient hair loss prevention, hair-growth effect and dandruff / kayumi prevention effect on the scalp cannot be obtained. It is not preferable because it may be shown. In the case where the testosterone 5α reductase inhibitor is a solvent extract of a plant, it is expressed in terms of% by weight as a dried product or an extract after removing the extract solvent.

The composition for scalp and hair of the present invention contains, in addition to the above-mentioned essential components, other components usually used in cosmetics, such as oils, surfactants, and moisturizers, as long as the effects of the present invention are not impaired. It can be manufactured by a conventional method according to the desired dosage form by appropriately mixing a solvent such as an agent, a thickener, an ultraviolet absorber, an antioxidant, an antiseptic, a fragrance, a pigment, water, and an alcohol as needed. it can.

The composition for scalp hair of the present invention includes cosmetics,
Pharmaceutical, an external preparation applied to the scalp or hair as a quasi-drug, its dosage form is arbitrary, for example, liquid, emulsion,
Ointments, creams, gels, aerosols, and other dosage forms that can be applied externally may be used. For example, they are used in the form of tonics, scalp treatments, and the like.

[0023]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. In the following examples, the amounts are by weight. As decyltetradecyldimethylamine oxide, 2-decyltetradecyldimethylamine oxide was used.

For the examples and comparative examples shown in Tables 1 and 2, the hair growth effect, hair loss prevention effect and dandruff / kayumi prevention effect were examined by the following tests and evaluation methods. The results are shown in "Table 3,""Table4," and "Table 5."

"Hair-growth effect test" In order to examine the hair-growth effect of the scalp hair composition, a tricogram test was carried out.
The test subjects were male, and each group of the examples and the comparative examples was 10 people. The test period was 4 months, and during the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day.
Immediately before the start of application and after the end of the application for 4 months, 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. (%) Was calculated. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria. (Judgment criteria) Remarkable effect: Hair root telogen rate decreased by 30% or more Effective: Hair root telogen rate decreased by 20% or more Weak effect: Hair root telogen rate decreased by 10% or more No effect: Hair root telogen rate: 10 Less than increase or less (hair growth effect evaluation criteria) The hair growth effect was evaluated when the number of subjects with significant effects and effects exceeded 50%, and the others were invalid.

"Test of hair loss prevention effect" In order to examine the hair loss prevention effect of the composition for scalp hair, the change in the number of hair loss due to hair washing before and after using the samples of Examples and Comparative Examples was measured. The test subjects were male, and each group of the comparative example and the example was 10 people. The test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period. During the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day. During the test period, the hair was washed every other day to collect the hair loss, and the number of end hairs was counted for one week. The number of hair loss was evaluated using the number of hair loss per hair washing during the sample application period, and the average value of the last week in the first half and the average value of the last week in the second half were compared. This result was determined based on the following criteria. (Judgment criteria) ++: The number of hair loss decreased by 70 or more, and a remarkable effect was recognized. +: The number of hair loss was reduced by 40 or more, and a considerable effect was recognized. ±: The number of hair loss was reduced by 10 or more, and a slight effect was recognized. -: The number of hair loss was less than 10 or the number of hair loss was increased, and no effect was observed. (Evaluation Criteria) For the evaluation of the hair loss preventing effect, the case where the ratio of ++ and + subjects was 50% or more was valid, and the others were invalid.

"Test for the effect of preventing dandruff and Kayumi"
Ten males in each of the comparative examples and the examples were examined for dander dandruff and kayumi after the test, and evaluated based on the amount of protein in dandruff and the degree of kayumi. The sample was applied for three months, during which time the hair was washed once a day with a shampoo containing no drug, and the sample was applied to the scalp twice a day, twice a day. At the end of the test, head dandruff was collected from the test subject with a suction device before washing the hair, and the amount of protein in the dandruff was measured. The scalp Kayumi was examined for each subject, and the degree was evaluated according to the following criteria. 3: Strong Kayumi 2: Kayumi 1: Some Kayumi 0: No Kayumi

The solvent extract of the plant used in the examples is as follows. (1) Fennel extract is from Fennel (Foeniculum vulg)
are miller), and the extract was extracted in 70% ethanol at room temperature for 1 week, filtered, and the filtrate was concentrated to remove the solvent. (2) The cashew extract was made from Polygonum multi
The dried product of the tuberous root of K. florum Thunbergii) was cut into small pieces, extracted in 50% ethanol under heating at 50 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (3) Licorice extract is Glycyrrhiza glabra
The dried product of the roots and rhizomes of Linne or glycyrrhizauralensis Fisher) was minced, extracted in water at 100 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (4) Quachararate extract is qualarate (Jul
iania adstringens), and the bark was cut into pieces, extracted in methanol at 50 ° C. for 5 hours, and filtered.
A concentrate obtained by evaporating the solvent of the filtrate was used. (5) Coriander extract is Coriandrum
sativum Linne) was crushed, extracted in 75% ethanol at 70 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (6) Sansho extract is Zanthoxylum pip
(Eritum De Candolle or other congener plants) The dried product of the pericarp is shredded, extracted in ethanol at 50 ° C. for 5 hours, filtered, and the filtrate is concentrated to remove the solvent. did. (7) The Jankan extract was extracted from Jancan (Sterculia foeti)
da) The dried pericarp is cut into small pieces, and in ethyl acetate at 50 ° C.
After extraction under heating for 5 hours, filtration was performed, and a concentrate obtained by evaporating the solvent of the filtrate was used. (8) The clove extract is a clove (Syzygium aromaticum)
The dried product of the bud of Merrill et Perry) was extracted in ethanol under heating at 50 ° C. for 5 hours, and then filtered, and the concentrate obtained by distilling off the solvent of the filtrate was used. (9) Sanshishi extract is gardenia (Gardenia jasminoide)
s Ellis) was dried and pulverized, and extracted in butanol under heating at 50 ° C. for 5 hours, and then filtered. (10) The cuckoo thistle extract is a cuckoo thistle (Agera
tum conyzoides Linne)
After extraction in 0% ethanol under heating at 50 ° C. for 5 hours, filtration was performed, and a concentrate obtained by evaporating the solvent of the filtrate was used. (11) Peony extract is Paeonia lacti
(flora Pallas or other closely related plants) The dried product of the root is cut into small pieces, extracted in 90% ethanol at 50 ° C for 5 hours, filtered, and the filtrate is concentrated to remove the solvent. did.

[0029]

[Table 1]

[Table 2]

[Preparation Method] Decyltetradecyldimethylamine oxide was dissolved in 95% ethanol, and the medicines (fennel extract, cashew extract, licorice extract, quacharate extract, coriander extract, sansho extract, jankan extract) Product, clove extract, oxendrone, finasteride), dipropylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct,
A succinic acid and a fragrance were dissolved, and then a dye was added to purified water and dissolved. The solution was added to an ethanol part, and then stirred to obtain a transparent liquid lotion.

[0031]

[Table 3]

[Table 4]

[Table 5]

As is clear from Table 3, Table 4, and Table 5, the composition for scalp hair of the present invention is excellent in hair-growth effect, hair loss prevention effect, and dandruff / kayumi prevention effect. Are better.

Example 12 A lotion having the following composition was prepared by a conventional method. Ingredients% by weight 95% ethanol 55.0 Decyltetradecyldimethylamine oxide 10.0 Sanshishi extract 0.5 Pantothenylethyl ether 1.0 1,3-butylene glycol 1.5 POE hydrogenated castor oil (60 mol addition) 1.0 Succinic acid qs Perfume and pigment qs Purified water residue Production method: Dissolve decyltetradecyldimethylamine oxide in 95% ethanol, and extract sanshishi extract, pantothenyl ethyl ether, 1,3-butylene glycol, POE Dissolve the hardened castor oil (addition of 60 moles) and perfume. Next, succinic acid and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

Example 13 A lotion having the following composition was prepared by a conventional method. Ingredients% by weight 95% ethanol 75.0 Decyltetradecyldimethylamine oxide 0.03 Cuckoo thistle extract 1.0 Hinokitiol 0.2 Cepharanthin 0.05 Dipropylene glycol 1.0 POE (24 mol) / POP (13 mol) ) Tesyltetradecylether 0.5 Lactic acid qs Sodium lactate qs Flavors and dyes qs Purified water residue Production method: Dissolve decyltetradecyldimethylamine oxide in 95% ethanol, and extract cuckoo thistle extract, hinokitiol, cepharanthin, Dissolve dipropylene glycol, POE (24 mol), POP (13 mol) decyltetradecyl ether and perfume. Next, lactic acid, sodium lactate and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

Example 14 A lotion having the following composition was prepared by a conventional method. Ingredients Weight% 95% ethanol 60.0 Decyltetradecyldimethylamine oxide 20.0 Peony extract 0.3 Mononitroguaiacol sodium 1.0 Vitamin B ₆ 0.5 6-Aminobenzylpurine 0.5 Pentadecanoic acid monoglyceride 1 0.0 Polyethylene glycol-400 0.5 POE hydrogenated castor oil (20 mol) 1.0 Phosphoric acid qs Perfume and dye qs Purified water residue Production method: Dissolve decyltetradecyldimethylamine oxide in 95% ethanol, Mononitroguaiacol sodium, vitamin B ₆ , peony extract, 6-
Dissolve aminobenzyl purine, diisopropylamine dichloroacetic acid, polyethylene glycol-400, POE hydrogenated castor oil (20 mol), and fragrance. Next, phosphoric acid and a dye are dissolved in purified water and added to the ethanol part.
The mixture was stirred to obtain a clear liquid lotion.

The compositions for scalp hair of Examples 12 to 14 are as follows:
Excellent hair growth and hair loss prevention effects, as well as dandruff and Kayumi prevention effects.

[0037]

According to the present invention, it is possible to provide a scalp hair composition having excellent hair-growth effects, hair loss prevention effects, dandruff and Kayumi prevention effects, and excellent safety.

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Masaaki Uemura 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa F-term in Shiseido Daiichi Research Center (reference) 4C083 AA111 AA112 AB282 AC102 AC122 AC182 AC302 AC422 AC432 AC472 AC561 AC562 AC642 AC852 AD042 AD531 AD552 AD632 BB51 CC37 DD01 DD31 EE01 EE22 EE23 FF05 4C084 AA24 CA13 DC32 MA22 MA63 NA14 ZA922 ZC202 4C088 AB03 AB12 AB13 AB22 AB23 AB26 AB29 AB32 AB35 AB38 AB40 AB43 AB54 AB60 AB99 AC04 AC05 AC06 AC11 AC13 BA07 BA09 BA10 CA03 MA01 MA63 NA14 ZA92 4C206 AA01 AA02 FA41 MA03 MA04 MA36 MA42 MA83 NA14 ZA92 ZC20

Claims (4)

[Claims] 1. A composition for scalp hair, comprising decyltetradecyldimethylamine oxide and a testosterone 5α reductase inhibitor. 2. The testosterone 5α reductase inhibitor according to claim 1, wherein the agent is Acacia catechu, Atikoria, Yerbarisa, Yew, Intin, Woro, Fennel, Usbena oy, Eijitsu, Ortiganigra, Onji, Kagosou,
Kakocha, Kashuu, Cuckoo Thistle, Antelope, Guarana, Cardosanto, Licorice, Catalpa, Calendula, Kinmokusei, Kaigai, Kengoshi, Gennoshoko, Kucharararate, Kusananou, Kumaseba, Gobishi, Goboushi, Coriander, Saikashi, Sashio, Sashio, Saiko, Sashio Shazenshi, Jankan, Jouzan, Cedron, Senso, Sokuhakuyou, Soyou, Daioh, Down Trawas, Chankapiedra,
Clove, Nigaki, Areca, Machiko, Mokka, Yakumoso, Yamahagi, Yokunin, Legro, Rosin, Cotton Extracted from one or more plants selected from the group consisting of cotton, oxendrone, or finasteride The composition for scalp hair according to claim 1. 3. The scalp hair according to claim 1, wherein the content of the decyltetradecyldimethylamine oxide is 0.0001 to 20% by weight based on the total amount of the scalp hair composition. Composition. 4. The content of the testosterone 5α reductase inhibitor is 0.0
3. The composition according to claim 1, wherein the content is from 0.01 to 10% by weight.
Or the composition for scalp hair according to 3.