JP2000044439A - Composition for scalp and hair treatment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a scalp and hair treatment composition having excellent hair-tonic effect, falling-off preventing effect, dandruff and itchiness preventing effect on scalp and safety by including oleyldimethylamine oxide, isostearyldimethylamine oxide and a testosterone 5α-reductase inhibitor. SOLUTION: The objective composition contains (A) oleyldimethylamine oxide of formula I and/or isostearyldimethylamine oxide of formula II and (B) a testosterone 5α-reductase inhibitor preferably selected from Uncaria gambir, Taxus cuspidata, Artemisia capillaris, Foeniculum vulgare, Malva sylvestris var. sylvestris, Rosa multiflora, Polygala tenuifolia, Prunella vulgaris, Polygonum multiflorum, Ageratum conyzoides, Valeriana fauriei, Paullinia cupana, Glycyrrhiza glabra, Catalpa ovata, Calendula officinalis, etc. The amounts of the components A and B in the composition are preferably 0.0001-20 wt.% and 0.001-5 wt.%, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composition for scalp hair. More specifically, the present invention relates to a composition for scalp hair which has an excellent hair-growing effect, an anti-hair loss effect and an anti-dandruff / kayumi effect, and is excellent in safety.

[0002]

2. Description of the Related Art There are various types of scalp hair compositions, and products corresponding to various scalp hair conditions are hair cosmetics,
It has been developed as a hair restorer and the like. For example, products have been developed that prevent hair loss by preventing dandruff and Kayumi on the scalp.

[0003] In today's aging society, various troubles on the scalp are increasing along with an increase in social stress, and the demand for scalp hair cosmetics corresponding to troubles on the scalp is rapidly increasing.

In general, baldness and alopecia of the head, thinning of hair, dandruff and kayumi of the scalp are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, and production of lipid peroxide. And a decrease in blood flow to the hair follicle and stress.

[0005] In addition, when sufficient nutrition is not supplied to hair follicles for growing durable and beautiful hair, fine hair and thin hair may be caused. Also, a decrease in blood flow to the hair follicle results in a lack of nutrition and a reduced function of excreting waste products.

[0006] From such a point of view, improving turnover of the stratum corneum and excessive sebum secretion in the scalp solves at least a decrease in blood flow function in the scalp and solves problems in the scalp and hair. It is an indispensable point on the top.

[0007] Conventional scalp hair compositions generally contain a substance having an action of removing or reducing the factors considered to be the cause of baldness and hair loss. For example,
Vitamins such as vitamin B and vitamin E; amino acids such as serine and methionine; assembly extracts; vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as purple root extract;
Hormonal preparations for women such as estradiol, skin function enhancers such as cepharanthin, etc. are blended and used for prevention and treatment of baldness, hair loss and hair thinning.

[0008]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the composition for scalp and hair. There is a problem in that the compounding amount is limited due to an increased tendency to accompany the irritating feeling and redness, and the desired effect cannot always be sufficiently obtained.

The inventors of the present invention have conducted intensive studies in view of the above viewpoints, and as a result, by combining oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide with a testosterone 5α reductase inhibitor, excellent nutrients have been obtained. The present inventors have found that a composition for scalp hair which has a hair effect, an anti-hair loss effect, an anti-dandruff and kayumi effect on the scalp, and is excellent in safety can be obtained, and has completed the present invention.

An object of the present invention is to provide a composition for scalp hair which has an excellent hair-growing effect, an effect of preventing hair loss, an effect of preventing dandruff and swelling of the scalp and is also excellent in safety.

[0011]

That is, the present invention provides a composition for scalp hair comprising oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide and a testosterone 5α reductase inhibitor. Is what you do.

The present invention also relates to the testosterone 5α.
Reductase inhibitors are used as Asenyaku, Atikoria, Yerbarisa, Yew, Intin, Woro, Fennel,
Usbenioi, Agetsu, Ortiganigra, Onji, Kagosou, Kakocha, Kashuu, Cuckoo Thistle,
Valerian, guarana, cardosanto, licorice, catalpa, calendula, chinensis, scallop, kengoshi,
Gennoshoko, Quacharate, Kusanaw, Kumaseba, Gobishi, Goboushi, Coriander, honey locust,
Psycho, Sanshishi, Sansho, Peony, Shazenshi, Jankan, Jouzan, Sedron, Senso, Sokuhakuyou, Soyou, Daio, Down Trawas, Chankapiedra, Chowji, Nigaki, Areca, Machiko,
Mokka, Yakumoso, Yamahagi, Yokuinin, Legro,
Rosin, a solvent-extracted extract of one or more plants selected from the group consisting of cotton, oxendrone, or
It is intended to provide the above composition for scalp hair, which is finasteride.

Further, the present invention is characterized in that the content of the oleyldimethylamine oxide and / or isostearyldimethylamine oxide is 0.0001 to 20% by weight based on the total amount of the composition for scalp hair. It is intended to provide the above composition for scalp hair.

The present invention also relates to the testosterone 5α.
The present invention provides the above composition for scalp hair, wherein the content of the reductase inhibitor is 0.001 to 5% by weight based on the total amount of the composition for scalp hair.

[0015]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The oleyldimethylamine oxide used in the present invention is a known compound represented by the following general formula.

Embedded image Isostearyl dimethylamine oxide is a known compound represented by the following general formula.

Embedded image All are known as surfactants having good foam stability, excellent viscosity and degreasing power.

The testosterone 5α reductase inhibitor used in the present invention is a substance that inhibits the action of testosterone 5α reductase on testosterone. Preferred testosterone 5α reductase inhibitors in the present invention include acenyak, atikoria, yervalisa, yew, intin, Woro, Fennel, Usbania Oy,
Agetsu, Ortiganigra, Onji, Kagosou, Kakocha, Kashu, Cuckoo Thistle, Valeriana officinalis, Guarana, Cardosanto, Licorice, Catalpa, Calendula,
Golden finch, kaygai, kengoshi, gennoshoko,
Quacharate, Celandine, Kumaseva, Gobishi,
Goboushi, coriander, honey locust, psycho, sanshishi, sansho, peony, shazenshi, jankan, jozan, cedron, senso, sokuhakuyou, soyou, rhubarb, downtrawas, chancapiedra,
It is a solvent-extracted extract, oxendrone, or finasteride of one or more plants selected from the group consisting of clove, nigaki, areca, machiko, mocca, yam moth, yamahagi, yokunin, reglo, rosin, and cotton.

The above-mentioned solvent-extracted plant extract is an extract with water or an organic solvent, for example, a dry powder or a non-dried powder of the above-mentioned plant, flower, seed, fruit, leaf, root or whole plant. The cut material is heated with water, methanol, ethanol, propylene glycol, 1,3-butylene glycol, butanol, chloroform, dichloroethane, carbon tetrachloride, ethyl acetate, or an ether or a mixture thereof at a temperature of 30 to 70 ° C. Extract with stirring for 1 to 10 hours, or extract at room temperature for 1 to 20 days, filter,
The filtrate may be concentrated, and further concentrated under reduced pressure to dryness. In the present invention, it can be used at the stage of a concentrated solution or at the stage of a dried product.

The amount of oleyldimethylamine oxide and / or isostearyldimethylamine oxide is
It is 0.0001 to 20% by weight, preferably 0.05% to 5% by weight, based on the total amount of the scalp hair composition. If the amount is less than 0.0001% by weight, sufficient hair-growth effects, hair loss-preventing effects and scalp dandruff / kayumi-preventing effects cannot be obtained.
If it exceeds 0% by weight, it gives an unpleasant sticky or irritating feeling to the scalp during use, which is not preferable.

The amount of the testosterone 5α reductase inhibitor is 0.0 to the total amount of the scalp hair composition.
It is 0.01 to 5% by weight, preferably 0.01% to 5% by weight. If the amount is less than 0.0001% by weight, sufficient hair loss prevention, hair-growth effect and dandruff / kayumi prevention effect on the scalp cannot be obtained. If the amount exceeds 5% by weight, unpleasant irritation or hormonal action is exerted on the preparation or on the scalp. It is not preferable because it may be shown. In the case where the testosterone 5α reductase inhibitor is a solvent extract of a plant, it is expressed in terms of% by weight as a dried product or an extract after removing the extract solvent.

The composition for scalp and hair of the present invention contains, in addition to the above-mentioned essential components, other components usually used in cosmetics, such as oils, surfactants, and moisturizers, as long as the effects of the present invention are not impaired. It can be manufactured by a conventional method according to the desired dosage form by appropriately mixing a solvent such as an agent, a thickener, an ultraviolet absorber, an antioxidant, an antiseptic, a fragrance, a pigment, water, and an alcohol as needed. it can.

The composition for scalp hair of the present invention includes cosmetics,
Pharmaceutical, an external preparation applied to the scalp or hair as a quasi-drug, its dosage form is arbitrary, for example, liquid, emulsion,
Ointments, creams, gels, aerosols, and other dosage forms that can be applied externally may be used. For example, they are used in the form of tonics, scalp treatments, and the like.

[0023]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. In the following examples, the amounts are by weight.

For the examples and comparative examples shown in Tables 1 and 2, the hair growth effect, hair loss prevention effect and dandruff / kayumi prevention effect were examined by the following tests and evaluation methods. The results are shown in "Table 3,""Table4," and "Table 5."

"Hair-growth effect test" In order to examine the hair-growth effect of the scalp hair composition, a tricogram test was carried out.
The test subjects were male, and each group of the examples and the comparative examples was 10 people. The test period was 4 months, and during the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day.
Immediately before the start of application and after the end of the application for 4 months, 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. (%) Was calculated. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria. (Judgment criteria) Remarkable effect: Hair root telogen rate decreased by 30% or more Effective: Hair root telogen rate decreased by 20% or more Weak effect: Hair root telogen rate decreased by 10% or more No effect: Hair root telogen rate: 10 Less than increase or less (hair growth effect evaluation criteria) The hair growth effect was evaluated when the number of subjects with significant effects and effects exceeded 50%, and the others were invalid.

"Test of hair loss prevention effect" In order to examine the hair loss prevention effect of the composition for scalp hair, the change in the number of hair loss due to hair washing before and after using the samples of Examples and Comparative Examples was measured. The test subjects were male, and each group of the comparative example and the example was 10 people. The test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period. During the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day. During the test period, the hair was washed every other day to collect the hair loss, and the number of end hairs was counted for one week. The number of hair loss was evaluated using the number of hair loss per hair washing during the sample application period, and the average value of the last week in the first half and the average value of the last week in the second half were compared. This result was determined based on the following criteria. (Judgment criteria) ++: The number of hair loss decreased by 70 or more, and a remarkable effect was recognized. +: The number of hair loss was reduced by 40 or more, and a considerable effect was recognized. ±: The number of hair loss was reduced by 10 or more, and a slight effect was recognized. -: The number of hair loss was less than 10 or the number of hair loss was increased, and no effect was observed. (Evaluation Criteria) For the evaluation of the hair loss preventing effect, the case where the ratio of ++ and + subjects was 50% or more was valid, and the others were invalid.

"Test for the effect of preventing dandruff and Kayumi"
Ten males in each of the comparative examples and the examples were examined for dander dandruff and kayumi after the test, and evaluated based on the amount of protein in dandruff and the degree of kayumi. The sample was applied for three months, during which time the hair was washed once a day with a shampoo containing no drug, and the sample was applied to the scalp twice a day, twice a day. At the end of the test, head dandruff was collected from the test subject with a suction device before washing the hair, and the amount of protein in the dandruff was measured. The scalp Kayumi was examined for each subject, and the degree was evaluated according to the following criteria. 3: Strong Kayumi 2: Kayumi 1: Some Kayumi 0: No Kayumi

The solvent extract of the plant used in the examples is as follows. (1) Fennel extract is from Fennel (Foeniculum vulg)
are miller), and the extract was extracted in 70% ethanol at room temperature for 1 week, filtered, and the filtrate was concentrated to remove the solvent. (2) The cashew extract was made from Polygonum multi
The dried product of the tuberous root of K. florum Thunbergii) was cut into small pieces, extracted in 50% ethanol under heating at 50 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (3) Licorice extract is Glycyrrhiza glabra
The dried product of the roots and rhizomes of Linne or glycyrrhizauralensis Fisher) was minced, extracted in water at 100 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (4) Quachararate extract is qualarate (Jul
iania adstringens), and the bark was cut into pieces, extracted in methanol at 50 ° C. for 5 hours, and filtered.
A concentrate obtained by evaporating the solvent of the filtrate was used. (5) Coriander extract is Coriandrum
sativum Linne) was crushed, extracted in 75% ethanol at 70 ° C. for 5 hours, filtered, and the filtrate was concentrated to remove the solvent. (6) Sansho extract is Zanthoxylum pip
(Eritum De Candolle or other congener plants) The dried product of the pericarp is shredded, extracted in ethanol at 50 ° C. for 5 hours, filtered, and the filtrate is concentrated to remove the solvent. did. (7) The Jankan extract was extracted from Jancan (Sterculia foeti)
da) The dried pericarp is cut into small pieces, and in ethyl acetate at 50 ° C.
After extraction under heating for 5 hours, filtration was performed, and a concentrate obtained by evaporating the solvent of the filtrate was used. (8) The clove extract is a clove (Syzygium aromaticum)
The dried product of the bud of Merrill et Perry) was extracted in ethanol under heating at 50 ° C. for 5 hours, and then filtered, and the concentrate obtained by distilling off the solvent of the filtrate was used. (9) Sanshishi extract is gardenia (Gardenia jasminoide)
s Ellis) was dried and pulverized, and extracted in butanol under heating at 50 ° C. for 5 hours, and then filtered. (10) The cuckoo thistle extract is a cuckoo thistle (Agera
tum conyzoides Linne)
After extraction in 0% ethanol under heating at 50 ° C. for 5 hours, the mixture was filtered, and the concentrate obtained by distilling off the solvent of the filtrate was used. (11) Peony extract is Paeonia lacti
(flora Pallas or other closely related plants) The dried product of the root is cut into small pieces, extracted in 90% ethanol at 50 ° C for 5 hours, filtered, and the filtrate is concentrated to remove the solvent. did.

[0029]

[Table 1]

[Table 2]

[Preparation method] Oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide were dissolved in 95% ethanol, and a drug (a fennel extract, a cashew extract, a licorice extract, a quacharate extract, a coriander extract, Sansho extract, Jankan extract, Clove extract, oxendron, finasteride), dipropylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, succinic acid, and fragrance are dissolved, and then the pigment is added to purified water. After dissolving and adding to the ethanol part, the mixture was stirred to obtain a transparent liquid lotion.

[0031]

[Table 3]

[Table 4]

[Table 5]

As is clear from Table 3, Table 4, and Table 5, the composition for scalp hair of the present invention is excellent in hair-growth effect, hair loss prevention effect, and dandruff / kayumi prevention effect. Are better.

Example 14 A lotion having the following composition was prepared. Ingredients% by weight 95% ethanol 75.0 Isostearyl dimethylamine oxide 5.0 Sanshishi 1.5 1,3-butylene glycol 1.5 POE hydrogenated castor oil (60 mol addition) 1.0 Succinic acid Appropriate amount Flavor and pigment Purified water residue Production method: Dissolve isostearyl dimethylamine oxide in 95% ethanol, and add sansisi, isostearyl dimethylamine oxide 1,3-butylene glycol,
Dissolve POE hydrogenated castor oil (60 moles added) and fragrance. Next, succinic acid and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

Example 15 A lotion having the following composition was prepared. Ingredients 95% ethanol 55.0 Isostearyl dimethylamine oxide 5.0 Coriander 0.5 Dipropylene glycol 1.0 POE (24 mol) / POP (13 mol) Tesyl tetradecyl ether 0.5 Lactic acid Suitable amount Sodium lactate Appropriate amount Perfume and dye Appropriate amount Purified water residue Production method: Dissolve decyltetradecyldimethylamine oxide in 95% ethanol, and add coriander, dipropylene glycol, POE (24 mol) / POP (13 mol) decyltetradecyl ether, perfume Allow to dissolve. Next, lactic acid, sodium lactate, and a dye were dissolved in purified water, added to the ethanol part, and then stirred to obtain a transparent liquid lotion.

Example 16 A lotion having the following composition was prepared. Ingredients Weight% 95% Ethanol 75.0 Oleyldimethylamine oxide 0.1 Yoquinin 1.0 Glycerin 1.0 POE hydrogenated castor oil (60 mol) 2.0 Citric acid qs Sodium citrate qs Flavor and pigment qs Purified water residue Min Production method: Dissolve oleyl dimethylamine oxide in 95% ethanol, add yoquinin, glycerin, POE
Dissolve the hydrogenated castor oil (60 moles) and perfume. Next, citric acid, sodium citrate and a dye were dissolved in purified water, added to the ethanol part, and then stirred to obtain a transparent liquid lotion.

Example 17 A lotion having the following composition was prepared. Ingredients Weight% 95% Ethanol 65.0 Oleyldimethylamine oxide 5.0 Licorice 1.0 Rhubarb 1.0 1,3 Butylene glycol 1.0 POE (10 mol) POP (20 mol) Tesyltetradecyl ether 1. 0 Lactic acid appropriate amount Sodium lactate appropriate amount Fragrance and pigment appropriate amount Purified water residue Production method: Oleyldimethylamine oxide is dissolved in 95% ethanol, and liquorice, rhubarb, 1,3 butylene glycol, POE (10 mol) and POP (20 mol) Dissolve decyl tetradecyl ether and perfume. Next, lactic acid, sodium lactate, and a dye were dissolved in purified water, added to the ethanol part, and then stirred to obtain a transparent liquid lotion.

Example 18 A lotion having the following composition was prepared. Ingredients Weight% 95% Ethanol 75.0 Oleyldimethylamine oxide 3.0 Isostearyldimethylamine oxide 2.0 Peony 0.5 Gennoshow 0.05 Polyethylene glycol-1000 0.5 POE hydrogenated castor oil (100 mol) 0 .05 Malic acid Appropriate amount Perfume and pigment Appropriate amount Purified water residue Production method: Oleyl dimethylamine oxide and isostearyl dimethylamine oxide are dissolved in 95% ethanol, and then peonies, ginger pepper, polyethylene glycol-1000, POE hydrogenated castor oil (1
00 mol) and dissolve the perfume. Next, malic acid and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

The compositions for scalp hair of Examples 14-18 were
Excellent hair growth and hair loss prevention effects, as well as dandruff and Kayumi prevention effects.

[0039]

According to the present invention, it is possible to provide a scalp hair composition having excellent hair-growth effects, hair loss prevention effects, dandruff and Kayumi prevention effects, and excellent safety.

Continued on the front page (72) Inventor Masaaki Uemura 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture F-term in Shiseido Daiichi Research Center (reference) 4C083 AA071 AA072 AA111 AA112 AC102 AC122 AC182 AC292 AC302 AC432 AC561 AC562 AC851 AC852 AD042 AD491 AD492 BB53 CC31 CC37 DD01 DD23 DD27 EE10 EE12 EE22 EE23 FF05 4C084 AA24 DC32 MA17 MA63 NA14 ZA362 ZA891 ZA921 ZA922 ZB112 ZC201 ZC202 ZC752 4C088 AB03 AB12 AB13 AB14 AB21 AB23 AB23 AB64 AB66 AB77 AB83 AC02 AC03 AC04 AC05 AC11 AC13 AD09 AD12 BA09 BA10 CA05 CA06 CA08 MA17 MA63 NA14 ZA36 ZA89 ZA92 ZB11 ZC20 ZC75 4C206 AA01 AA02 CB24 HA40 KA18 MA02 MA03 MA04 MA21 MA37 MA83 NA14 ZA36 ZA89 ZAZZAZZA92

Claims (4)

[Claims] An oleyl dimethylamine oxide and / or
Alternatively, a composition for scalp hair comprising isostearyl dimethylamine oxide and a testosterone 5α reductase inhibitor. 2. The testosterone 5α reductase inhibitor according to claim 1, wherein the agent is Acacia catechu, Atikoria, Yerbarisa, Yew, Intin, Woro, Fennel, Usbena oy, Eijitsu, Ortiganigra, Onji, Kagosou,
Kakocha, Kashuu, Cuckoo Thistle, Antelope, Guarana, Cardosanto, Licorice, Catalpa, Calendula, Kinmokusei, Kaigai, Kengoshi, Gennoshoko, Kucharararate, Kusananou, Kumaseba, Gobishi, Goboushi, Coriander, Saikashi, Sashio, Sashio, Saiko, Sashio Shazenshi, Jankan, Jouzan, Cedron, Senso, Sokuhakuyou, Soyou, Daioh, Down Trawas, Chankapiedra,
Clove, Nigaki, Areca, Machiko, Mokka, Yakumoso, Yamahagi, Yokunin, Legro, Rosin, Cotton Extracted from one or more plants selected from the group consisting of cotton, oxendrone, or finasteride The composition for scalp hair according to claim 1. 3. The content of the oleyl dimethyl amine oxide and / or isostearyl dimethyl amine oxide is 0.0001 to 2 with respect to the total amount of the scalp hair composition.
The composition for scalp hair according to claim 1 or 2, which is 0% by weight. 4. The content of the testosterone 5α reductase inhibitor is 0.0
The composition for scalp hair according to claim 1, 2 or 3, wherein the content is from 0.01 to 5% by weight.