JP2002128687A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sin care preparation applicable to even persons with sensitive skin, particularly even persons sensitive to p-oxybenzoic esters. SOLUTION: This skin care preparation contains a natural ingredient extracted from the seeds or peels of citrus fruits and at least one ingredient selected from phenoxyethanol and hinokitiol. Another version of this preparation further contains, besides the above two kinds of ingredients, at least two polyhydric alcohols selected from 1,2-pentanediol, 1,3-butylene glycol and propylene glycol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a preparation for external use on the skin, such as cosmetics and pharmaceuticals, which is highly safe and does not use antibacterial agents such as paraoxybenzoates.

[0002]

2. Description of the Related Art Various antibacterial agents are used in skin external preparations such as cosmetics and pharmaceuticals. Particularly widely used are paraoxybenzoates. Paraoxybenzoates are widely used because of their good safety and antibacterial properties, but they may cause irritation to some people and may also act as environmental hormones.
Antimicrobial properties can be maintained to some extent by container and storage method. However, the usability and use are limited, and there has been a demand for the development of a skin external preparation that does not use paraoxybenzoates.

The antibacterial properties of citrus fruit seeds and epidermis are disclosed in JP-A-6-40834 and JP-A-7-292290.
And Japanese Patent Application Laid-Open No. 9-40516 for application to sprays, coating agents and wet tissues. Further, in JP-A-7-126142, it is used as a wrinkle improving agent.

[0004]

The antibacterial properties of the seeds of the fruits of citrus plants exhibit some antibacterial properties even when used alone. However, an external preparation for skin requires a broad antibacterial spectrum, and an external preparation for skin, especially recently. The number of people with dry skin, such as atopic dermatitis and senile xeroderma, is increasing, and moisture retention of the skin is one of the important required factors.

An object of the present invention is to provide a preparation which is plant-based, has good safety, has a mild effect on the skin, and has a sufficient moisturizing property.

[0006]

Accordingly, as a result of intensive studies, a skin external preparation comprising a natural component extracted from the seeds of citrus fruit and one or more selected from phenoxyethanol and hinokitiol is described in the present invention. It turned out to be optimal for my purpose. Furthermore, it contains natural components extracted from the seeds of the fruits of citrus plants and one or more selected from phenoxyethanol and hinokitiol, and is selected from 1,2-pentanediol, 1,3 butylene glycol, and propylene glycol. The use of one or more polyhydric alcohols results in a more suitable formulation.

[0007] Citrus plants refer to Rutaceae, Rutaceae, and Rutaceae in the Rutaceae family.
Grapefruit, summer tangerine, lemon, kabos, sudachi,
Unshu mandarin orange, Iyokan, orange, mandarin, hassaku,
Navel, Ponkan, etc. It refers to components extracted from the seeds and / or skins of citrus fruits, and conventional methods may be used to extract these. For example, the natural component used in the present invention can be extracted by squeezing or solvent extraction. For example, in a squeezing method, an extract can be squeezed out from the fruit of a citrus plant using a general squeezing machine, and separated and manufactured using a commercially available decanter or the like to extract the components. In addition, a solvent-extracted extract is obtained by pulverizing citrus plant fruits with a pulverizer such as a ball mill or a homogenizer, and then separating and producing the mixture using a solvent safe for the human body such as water or ethanol by Soxhlet extraction or filtration. be able to. Another option is to remove the added water and alcohol by evaporation or the like, and to obtain a concentrated extract from which 95% or more of the solvent used for removing the natural components has been removed.

The purpose of the use of the components extracted from the seeds and skins of the fruits of the citrus plants obtained by the above-described methods and the like in the present invention is to mainly use antibacterial properties. The antibacterial properties of the components obtained from fruit seeds are higher than the antibacterial properties, and when antibacterial effects are considered, extracts from fruit seeds are preferred. Since the extract from the fruit has a so-called citrus scent, it has a role as a fragrance and an effect as a masking agent for the raw material odor. Therefore, the seed or the epidermis alone or both may be mixed depending on the intended use.

[0009] In the present invention, seeds of citrus plant fruit;
Alternatively, the component concentration of the aqueous solution containing the natural components extracted from the skin depends on the type of citrus, the place of production, the plant part (seed or epidermis), the amount of phenoxyethanol and hinokitiol, the purpose of the formulation, and the container. Although there is no particular limitation, it is preferably 0.001% by weight to 10% by weight based on the preparation.

In addition, phenoxyethanol and hinokitiol may be used alone or in combination of two or more, and when 1,2-pentanediol, 1,3-butylene glycol and propylene glycol are added, the moisture retention is enhanced. It is effective as a formulation. Furthermore, there is no problem in combination with glycerin and other humectants. The amount of phenoxyethanol and hinokitiol varies depending on the conditions of the natural components extracted from the seeds or epidermis of the fruits of the citrus plant, the type of moisturizing required by the preparation, the type and amount of other humectants, the purpose of the preparation, etc. However, it is preferably 0.01% by weight to 10% by weight based on the preparation. 1,2
-The amounts of pentanediol, 1,3 butylene glycol and propylene glycol are determined according to the conditions of natural components extracted from the seeds or epidermis of citrus fruits, the amounts of phenoxyethanol and hinokitiol, and the moisturizing required by the preparation. Although it varies depending on the nature, type and amount of other humectants, purpose of the preparation, and the like, it is preferable that 1.
0% to 50% by weight is preferred.

[0011] These may be combined with other base materials for skin external preparations, additives and the like to prepare the necessary preparations. Although there is no particular contraindication, there is a substance that weakens antibacterial properties depending on the type. Therefore, depending on the amount of the substance, natural components extracted from the seeds or epidermis of citrus fruits or 1,2-pentanediol , 1,3 butylene glycol, propylene glycol, etc. need to be sufficiently studied. However, in the present invention, since the primary purpose is to impart antibacterial properties using a highly safe natural agent, components that are undesirable for safety and hygiene to the human body should not be used or should be kept in a small amount. Is desirable. Also,
Other antibacterial agents and cationic surfactants also have aspects that do not conform to the spirit of the present invention, and it is contrary to the spirit of the present invention to allow them to carry the main part of antibacterial properties.
It goes without saying that the amount is naturally limited.

The dosage form can be selected from various dosage forms such as ointments, lotions, emulsions, creams, packs, and gels, and is not particularly limited. Examples of a method for extracting a citrus plant fruit from seeds or epidermis and an example of an actual method for producing an external preparation for skin are described below, but are not particularly limited thereto.

Production Example 1 1 kg of dried grapefruit seeds was pulverized with a ball mill, 500 ml of ethanol was added, and the mixture was charged into a Soxhlet extractor and heated under reflux for 20 hours. The obtained extract was concentrated under reduced pressure to obtain about 35 g of a concentrated extract of grapefruit seeds.

Production Example 2 1 kg of skin of grapefruit was ground with a ball mill,
500 ml of ethanol was added, and the mixture was charged in a Soxhlet extractor and heated under reflux for 20 hours. The obtained extract was concentrated under reduced pressure to obtain a concentrated extract of about 80 g of grapefruit epidermis.

Production Example 3 1 kg of dried summer tangerine seeds were pulverized with a ball mill, 500 ml of ethanol was added, and the mixture was charged in a Soxhlet extractor and heated under reflux for 20 hours. The obtained extract was concentrated under reduced pressure to obtain a concentrated extract of about 30 g of summer tangerine seeds.

Example 1 (Cream type) Oil phase 8.0 parts by weight of squalane, 4.0 parts by weight of beeswax, 3.0 parts by weight of cetanol, 3.0 parts by weight of stearic acid, polyoxyethylene stearate (5E. 0) 2.0 parts by weight of cetyl ether, 1.2 parts by weight of polyoxyethylene (5E.0) stearyl ether,
E. FIG. 0) 0.6 parts by weight of stearyl ether, 0.3 parts by weight of polyoxyethylene (15E.0) lauryl ether, 0.1 parts by weight of sodium hydroxide, 1.0 part by weight of phenoxyethanol, 1.0 part by weight of propylene glycol Department,
1.0 part by weight of 1,2-pentanediol, Production Example 1-
0.1 part by weight, 74.7 parts by weight of water In the production method, the oil phase and the aqueous phase were separately heated, and the aqueous phase was gradually added to the oil phase while stirring, and then gradually cooled to 45 ° C.

Example 2 (Lotion type) Oil phase Perfume 0.2 parts by weight, olive oil 0.1 part by weight, sorbitan monostearate 0.5 part by weight, polyoxyethylene (20E.0) sorbitan monostearate 1 1.0 part by weight, polyoxyethylene (60E.0) hydrogenated castor oil 1.0 part by weight Aqueous phase hinokitiol 0.1 part by weight, 1,2-pentanediol 1.5 parts by weight, 1,3 butylene glycol 5.0 Parts by weight, Production Example 2-0.15 parts by weight, water 90.65 parts by weight

EXAMPLE 3 0.1 part by weight of Production Example 1 of Example 1 is replaced with Production Example 3-0.1
Manufactured in the same manner as in Example 1 except that the parts are replaced by parts by weight.

Example 4 Production was carried out in the same manner as in Example 1 except that 0.15 parts by weight of Production Example 2 of Example 2 was replaced with 0.15 parts by weight of grapefruit seed extract (manufactured by Chemie Brasilaira, Sao Paulo, Brazil). thing.

Example 5 0.1 part by weight of Production Example 1 of Example 1 was mixed with 0.05 of grapefruit oil (manufactured by Takasago International Corporation) and Production Example 3-0.05.
Manufactured in the same manner as in Example 1 except that the parts are replaced by parts by weight.

Example 6 0.15 parts by weight of Production Example 2 of Example 2 was combined with 0.05 part by weight of grapefruit seed extract (Chemie Brasilaira, Sao Paulo, Brazil) and Production Example 2
Manufactured in the same manner as in Example 1 except for replacing with −0.10.

Antibacterial test Escherichia coli ATCC
16404), Staphylococcus aureus
ccus aureus ATCC 6538), Pseudomonas aeruginosa A
TCC9027), Candida albicans (Candida al
bicans ATCC 10231), mold (Aspe)
rgillus niger ATCC 16404) was inoculated into 10 g of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa in an amount of about 106 cells per gram.
The cells were cultured at 37 ° C., and the viable cell count was measured immediately after inoculation, 1 day, 2 days, and 1 week. (Immediately after inoculation, the viable cell count of the inoculated bacterial solution was measured and determined from the dilution factor.) Candida fungi and mold were inoculated at 105 cells per gram, and then cultured at 25 ° C. Thereafter, the viable cell count was measured three weeks later. Tables 1 to 10 show the results.

[0023]

[0024]

[0025]

[0026]

[0027]

[0028]

[0029]

[0030]

[0031]

[0032]

Skin irritation test Skin sensitive persons, 5 women 18-49 years old and 33-4
Three 9-year-old men, a total of nine people, about 2 cm on the cheek skin under the eyes
The examples and comparative examples were applied to the left and right sides on all sides, and the skin was evaluated for irritation based on the following criteria. I didn't feel any stimulus = 0,
Slight irritation = 1, irritation = 2, strong irritation = 3 In the comparative examples, the production examples blended in the examples were replaced with methyl paraoxybenzoate in an amount showing the same antibacterial activity. The results are shown in Table 11, where the numerical values are the sum of the evaluation points.

[0034]

[0035]

[Effect] An external preparation for skin containing a natural component extracted from the seed or epidermis of a citrus fruit and one or more selected from phenoxyethanol and hinokitiol,
It contains natural components extracted from the seeds or epidermis of citrus fruits and one or more selected from phenoxyethanol and hinokitiol, and is selected from 1,2-pentanediol, 1,3-butylene glycol and propylene glycol. Skin external preparations containing one or more polyhydric alcohols can also be applied to people with sensitive skin, especially those who are sensitive to paraoxybenzoate.

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Claims (3)

[Claims] 1. An external preparation for skin containing a natural component extracted from the seed or epidermis of a citrus fruit and at least one selected from phenoxyethanol and hinokitiol. 2. A composition comprising a natural component extracted from the seeds or epidermis of a citrus fruit and at least one selected from phenoxyethanol and hinokitiol, and comprising 1,2-pentanediol, 1,3-butylene glycol and propylene glycol. External preparation for skin containing two or more polyhydric alcohols selected from 3. The external preparation for skin according to claim 1, wherein the fruit of the citrus plant is grapefruit.