JPH11180833A - Composition for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition having excellent depilation preventing effects, dandruff and itch preventing effects on scalp and excellent safety, by including acetylated hyaluronic acid and a hair follicle activator. SOLUTION: This composition comprises (A) 0.001-10 wt.% (based on the total of the composition, hereinafter in the same way), preferably 0.01-5 wt.% of acetylated hyaluronic acid, (B) 0.01-5 wt.%, preferably 0.01-3 wt.% of a hair follicle activator and (C) optionally an oil component, a surfactant, a humectant, a thickening agent, a perfume, a coloring matter, a solvent, etc. The number of substitution of acetyl groups of the component A is preferably 2-4 on the average in a repeating unit of the formula (R<1> to R<4> are each H or an acetyl subjected to ester bond and two or more of R<1> to R<4> are acetyl on the average in each repeating structure; R<5> is H or an alkali metal. Nicotinic acid amide, vitamin B6 (derivative) or the like is preferable as the component B.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composition for scalp hair. More specifically, it has an excellent hair loss prevention effect and dandruff
The present invention relates to a scalp hair composition having a Kayumi prevention effect.

[0002]

2. Description of the Related Art There are various types of scalp hair compositions, and products corresponding to various scalp hair conditions are hair cosmetics,
It has been developed as a hair restorer and the like. For example, products have been developed that prevent hair loss by preventing dandruff and Kayumi on the scalp.

[0003] In today's aging society, various troubles on the scalp are increasing along with an increase in social stress, and the demand for scalp hair cosmetics corresponding to troubles on the scalp is rapidly increasing.

In general, baldness and alopecia of the head, thinning of hair, dandruff and kayumi of the scalp are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, and production of lipid peroxide. And a decrease in blood flow to the hair follicle and stress.

[0005] In addition, when sufficient nutrition is not supplied to hair follicles for growing durable and beautiful hair, fine hair and thin hair may be caused. Also, a decrease in blood flow to the hair follicle results in a lack of nutrition and a reduced function of excreting waste products.

[0006] From such a point of view, improving turnover of the stratum corneum and excessive sebum secretion in the scalp solves at least a decrease in blood flow function in the scalp and solves problems in the scalp and hair. It is an indispensable point on the top.

[0007] Conventional scalp hair compositions generally contain a substance having an action of removing or reducing the factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, assembly extracts, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, hormonal agents for women such as estradiol, cepharanthin and the like It contains a skin function enhancer and the like, and is used for preventing and treating baldness, hair loss, and hair thinning.

[0008]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the scalp hair composition. Since the tendency to accompany irritation and redness increases, there is a problem that the compounding amount is limited and a desired effect cannot always be sufficiently obtained.

The inventors of the present invention have conducted intensive studies in view of the above viewpoints. As a result, the combination of acetylated hyaluronic acid and a specific hair follicle activator has an excellent hair loss preventing effect and dandruff on the scalp. The present inventors have found that a composition for scalp hair which has a Kayumi prevention effect and is also excellent in safety has been obtained, and has completed the present invention.

It is an object of the present invention to provide a composition for scalp hair which has an excellent effect of preventing hair loss and an effect of preventing dandruff and swelling of the scalp and is also excellent in safety.

[0011]

That is, the present invention provides a scalp and hair composition comprising acetylated hyaluronic acid and a hair follicle activator.

Further, the present invention is characterized in that the acetylated hyaluronic acid has an average of 2 to 4 substitutions of an acetyl group in the repeating structural unit represented by the following chemical formula (Formula 2). And a composition for scalp hair.

Embedded image (Wherein, R ¹ , R ² , R ³ , and R ^{4 each} represent hydrogen or an acetyl group bonded through an ester bond, and on average, at least two or more of R ^{1 to} R ⁴ in each repeating structure are acetyl groups. R ⁵ represents hydrogen or an alkali metal atom.)

Furthermore, the present invention, the hair follicle activating agent, nicotinic acid amide, vitamin of B ₆ and derivatives thereof, biotin, pantothenic acid and its derivatives, cepharanthine, mononitroguayacol, mononitroguayacol sodium, 6-benzylaminopurine The composition for scalp hair is one or more selected from the group consisting of purine, diisopropylamine dichloroacetic acid, and hinokitiol.

[0014] The present invention also relates to the present invention, wherein the content of the acetylated hyaluronic acid is 0.00% to the total amount of the scalp hair composition.
1 to 10% by weight of the composition for scalp hair.

Further, the present invention provides the composition for scalp hair, wherein the content of the hair follicle activator is 0.001 to 5% by weight based on the total amount of the composition for scalp hair. Is what you do.

[0016]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The acetylated hyaluronic acid used in the present invention is a high molecular compound in which the hydroxyl group of hyaluronic acid is partially acetylated. The acetylation rate for the hydroxyl group is not particularly limited, but is represented by the following general formula [Chemical Formula 3]. The number of substitution of the acetyl group in the repeating structural unit is 2 to 2 on average
Four are preferred.

Embedded image (Wherein, R ¹ , R ² , R ³ , and R ^{4 each} represent hydrogen or an acetyl group bonded through an ester bond, and on average, at least two or more of R ^{1 to} R ⁴ in each repeating structure are acetyl groups. R ⁵ represents hydrogen or an alkali metal atom.)

The method for producing acetylated hyaluronic acid includes, for example, a method in which powdery hyaluronic acid is dispersed in acetic acid and reacted by adding trifluoroacetic anhydride as a catalyst, or a method in which p-toluenesulfonic acid is dispersed in acetic acid and p-toluenesulfonic acid is added. A method of reacting by adding acetic anhydride or a method of suspending in acetic anhydride solvent and adding concentrated sulfuric acid to react is known (see JP-A-6-9707 and JP-A-8-53501).

The amount of acetylated hyaluronic acid to be used in the present invention is usually 0.1% based on the total amount of the composition for scalp and hair.
001 to 10% by weight, preferably 0.01 to 5% by weight. If the amount is less than 0.001% by weight, sufficient hair loss prevention effect and dandruff / kayumi prevention effect on the scalp cannot be obtained, and 10% by weight.
Exceeding the scalp may give an unpleasant sticky feeling.

The hair follicle activating agent used in the present invention include, for example, nicotinic acid amide, vitamin of B ₆ and derivatives thereof, biotin, pantothenic acid and its derivatives, cepharanthine, mononitroguayacol, mononitroguayacol sodium, 6-benzylaminopurine , Diisopropylamine dichloroacetic acid, hinokitiol and the like, and in the present invention, one or more of these are preferably used.

The amount of the hair follicle activator used in the present invention is usually 0.001 to 5% by weight, preferably 0.01 to 3% by weight, based on the total amount of the scalp hair composition. 0.00
If the amount is less than 1% by weight, sufficient hair loss prevention and scalp dandruff and Kayumi preventive effects cannot be obtained. If the amount is more than 5% by weight, it may be difficult to formulate the composition or may give an unpleasant irritant feeling to the scalp. It is not preferable.

The composition for scalp and hair of the present invention contains, in addition to the above-mentioned essential components, other components usually used in cosmetics, such as oils, surfactants, and moisturizers, as long as the effects of the present invention are not impaired. It can be manufactured by a conventional method according to the desired dosage form by appropriately mixing a solvent such as an agent, a thickener, an ultraviolet absorber, an antioxidant, an antiseptic, a fragrance, a pigment, water, and an alcohol as needed. it can.

The composition for scalp hair of the present invention includes cosmetics,
Pharmaceutical, an external preparation applied to the scalp or hair as a quasi-drug, its dosage form is arbitrary, for example, liquid, emulsion,
Ointments, creams, gels, aerosols, and other dosage forms that can be applied externally may be used. For example, they are used in the form of tonics, scalp treatments, and the like.

[0024]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. In addition, in the following examples, the compounding amount is% by weight.
It is.

With respect to the examples and comparative examples shown in Tables 1 and 2, the hair removal effect and the dandruff / kayumi prevention effect were examined by the following tests and evaluation methods. The results are shown in “Table 3” and “Table 4”.

"Test for the effect of preventing hair loss" The change in the number of hair loss due to hair washing before and after using the samples (lotions) of the examples and comparative examples was measured. The test subjects were male, and each of the comparative example and the example was 10 persons in each group. The test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period. During the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day. During the test period, the hair was washed every other day to collect the hair loss, and the number of end hairs was counted for one week. The number of hair loss was evaluated by using the number of hair loss per hair washing during the sample application period, and the average value of the last week in the first half and the average value of the last week in the second half were compared. The results were judged according to the following criteria. A case where the proportion of subjects with + or more was 50% or more was evaluated as valid, and the others were evaluated as invalid. (Evaluation criteria) ++: The number of hair loss decreased by 70 or more, and a remarkable effect was recognized. +: The number of hair loss was reduced by 40 or more, and a considerable effect was recognized. ±: The number of hair loss was reduced by 10 or more, and a slight effect was recognized. -: The number of hair loss was less than 10 or the number of hair loss increased, and no effect was observed.

"Test for the effect of preventing dandruff and Kayumi"
A group of 10 men in each of the comparative example and the example were investigated for dandruff / kayumi after the test, and evaluated based on the amount of protein in dandruff and the degree of kayumi. The sample application period was three months. During this period, the hair was washed once a day with a shampoo containing no drug, and the sample was applied twice a day to the scalp twice a day. At the end of the test, head dandruff was collected from the subject with a suction device before washing the hair, the amount of protein in the dandruff was measured, and the average value was evaluated as the average dandruff amount. In addition, each subject was examined for scalp Kayumi, the degree was determined according to the following criteria, and the average was evaluated. (Judgment criteria) 3: There is strong Kayumi. 2: There is Kayumi. 1: There is a little Kayumi. 0: There is no Kayumi.

[0028]

[Table 1]

[Table 2]

[Production method] Acetylized hyaluronic acid, hair follicle activator, glycerin, POE hydrogenated castor oil (100 mol added) and perfume were dissolved in 95% ethanol. Next, malic acid and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

[0030]

[Table 3] 1

[Table 4]

As is clear from Tables 3 and 4, the examples of the present invention were excellent in the effect of preventing hair loss and the effect of preventing dandruff and kayumi.

Hereinafter, other embodiments of the present invention will be described.
All of the examples were excellent in the effect of preventing hair loss, the effect of preventing dandruff and Kayumi, the safety, and the stability.

Example 12: Lotion Ingredients Weight% 95% Ethanol 55.0 Acetylated Hyaluronic Acid 5.0 Nicotinamide 0.5 Hinokitiol 0.2 1,3-butylene glycol 1.5 POE hydrogenated castor oil (60 mol addition) 1.0 Succinic acid Appropriate amount Fragrance and pigment Appropriate amount Purified water residue Production method: Acetylated hyaluronic acid is dissolved in 95% ethanol, and nicotinamide, hinokitiol, 1,
3-butylene glycol, POE hydrogenated castor oil (60 mole addition) and perfume were dissolved. Next, succinic acid in purified water,
After dissolving the dye and adding it to the ethanol part, the mixture was stirred to obtain a transparent liquid lotion.

“Example 13: Lotion” Ingredients Ingredients% by weight 95% Ethanol 75.0 Acetylated hyaluronic acid 0.3 Pantothenyl ethyl ether 5.0 Cepharanthin 0.05 Dipropylene glycol 1.0 POE (24 mol) · POP (13 mol) decyltetradecyl ether 0.5 lactic acid proper amount sodium lactate proper amount fragrance and dye proper amount purified water residue Production method: Dissolve acetylated hyaluronic acid in 95% ethanol, pantothenyl ethyl ether, cepharanthin, dipropylene glycol , POE (24mol) ・ POP (13mol)
Tetrasyltetradecyl ether and perfume were dissolved. Next, lactic acid, sodium lactate and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

Example 14: Lotion Ingredients Weight% 95% Ethanol 60.0 Acetylated Hyaluronic Acid 3.0 Mononitroguaiacol Sodium 1.0 Vitamin B ₆ 0.5 6-Benzylaminopurine 0.5 Diisopropylamine Dichloroacetic acid 0.05 Polyethylene glycol-400 1.0 POE hydrogenated castor oil (20 mol) 1.0 Phosphoric acid Appropriate amount Flavor and pigment Appropriate amount Purified water residue Production method: Dissolve acetylated hyaluronic acid in 95% ethanol, mononitroguayacol sodium, vitamin B _6, 6- benzylaminopurine, diisopropylamine di chloroacetic acid, polyethylene glycol -40
0, POE hydrogenated castor oil (20 mol) and perfume were dissolved. Next, phosphoric acid and a dye were dissolved in purified water and added to the ethanol part, followed by stirring to obtain a transparent liquid lotion.

[0036]

According to the present invention, it is possible to provide a composition for scalp hair which has an excellent effect of preventing hair loss and also an excellent effect of preventing dandruff and Kayumi.

Claims (5)

[Claims] 1. A composition for scalp and hair, comprising acetylated hyaluronic acid and a hair follicle activator. 2. The acetylated hyaluronic acid according to claim 1, wherein the number of substitutions of the acetyl group in the repeating structural unit represented by the following chemical formula (Chemical Formula 1) is 2 to 4 on average. Composition for scalp hair. Embedded image (Wherein, R ¹ , R ² , R ³ , and R ^{4 each} represent hydrogen or an acetyl group bonded through an ester bond, and on average, at least two or more of R ^{1 to} R ⁴ in each repeating structure are acetyl groups. R ⁵ represents hydrogen or an alkali metal atom.) Wherein the hair follicle activating agent nicotinamide, vitamin of B ₆ and derivatives thereof, biotin, pantothenic acid and its derivatives, cepharanthine, mononitroguayacol, mononitroguayacol sodium, 6-benzylaminopurine, diisopropylamine di The scalp hair composition according to claim 1 or 2, wherein the composition is one or more selected from the group consisting of chloroacetic acid and hinokitiol. 4. The content of the acetylated hyaluronic acid is 0.001 to 10% by weight based on the total amount of the scalp hair composition.
The composition for scalp hair according to claim 1, 2, or 3. 5. The scalp hair according to claim 1, wherein the content of the hair follicle activator is 0.001 to 5% by weight based on the total amount of the scalp hair composition. Composition.