JPH1160450A - Hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic which is utilized in fields of medicines, quasi- drugs and cosmetics and has excellent hair-restoring effect such as depiratory prevention and hair-growing effect by formulating an extract from plants of the family Menispermaceae and the family Nymphaeaceae. SOLUTION: This hair tonic is obtained by formulating at least one kind or more selected from extracts from plants of the family Menispermaceae, the genus Menispermum (e.g. Menispermum daurium DC.) or the genus Cocculus (e.g. Cocculus laurifolius DC., Cocculus trilobus DC., etc.), plants of the family Nymphaeaceae, the genus Nelumbo (e.g. Nelumbo nucifera Gaertn.), plants of the family Malvaceae, the genus Abelmoschus (e.g. Ahelmoschus crinitus, Ahelmoschus manihot, etc.), plants of the family Gnetaceae, the genus Gnetum (e.g. Gnetum montanum and the like) and plants of the family Lauraceae, the genus machilus (e.g. Machilus bracteate and the like) preferably in an amount of 0.005-10 wt.% based on the whole weight of the composition. This hair tonic can be prepared in dosage forms of liquid, emulsion and ointment.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer and, more particularly, to a hair restorer having an excellent hair growth-inhibiting effect such as an anti-hair loss effect and a hair growth effect, which is used in the fields of pharmaceuticals, quasi-drugs and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the cause of baldness and hair loss has been removed.
Alternatively, a hair nourishing cosmetic in which various agents are blended in order to reduce the amount is known. In these hair-growing cosmetics, for example, in order to improve the blood flow to the hair root, assembly extract or an acetylcholine derivative is blended, or a female hormonal agent such as estradiol as an anti-androgen is blended. And hinokitiol for improving scalp metabolism are used for preventing and treating alopecia.

[0003] However, the mechanism of hair loss and hair growth is very complicated, and it is satisfactory to prevent hair loss only by blending the assembly extract or the like to promote blood circulation or reduce the activity of male hormones, as in the conventional hair restorer. No hair growth effect has been obtained.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a hair restorer containing an extract from a plant such as the genus Menispermum, which has an excellent anti-hair loss and hair growth promoting action, with few side effects. is there.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have intensively studied a medicinal agent having an excellent effect on the prevention and treatment of alopecia and having no side effects. As a result, genus Menispermum or Coccul
us genus plant, waterlily Nelumbo genus plant, mallow
It has been found that a composition containing at least one selected from an extract of a plant of the genus Abelmoschus, a plant of the genus Gnetum, and a plant of the genus Machilus has an excellent hair-growing effect, thereby completing the present invention. Reached.

[0006] That is, the present invention relates to Menis
Permum or Cocculus genus plant, Nymphaeaceae Nelu
An object of the present invention is to provide a hair tonic comprising at least one extract of a plant of the genus mbo, a plant of the genus Abelmoschus, a plant of the genus Gnetum, and a plant of the genus Machilus.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extract used in the present invention is extracted from the following plants. That is, a plant belonging to the genus Menispermum of the family Aphididae;
um dauricum), a plant belonging to the genus Cocculus, Cocculus laurifolius, and a shrimp (Cocc)
ulus trilobus)
tus), a plant of the genus Nelumbo belonging to the waterlily family; lotus (Nelumbo nu)
cifera), a plant of the genus Abelmoschus of the family Malvaceae; Butterfly (Abelmoschus crinitus), corn squirrel (Abelmoschus manihot), trolley mallow (Abelmosch)
us moschatus), Senshushu (Abelmoschus sagi)
ttifolius), okra (Abelmoschus esculentus), Gnetum family Gnetum genus plant;
num), Ginkgo biloba (Gnetum parvifoliu)
m), camphor tree Machilus genus plant; Euphorthein (Machilus bracteate), Euphorbia (Machilus lep)
tophylla), Tabunoki (Machilus thunbergii), Dauphin tenin (Machilus velutina), Tentenin (Machilus yannanensis), Green oak (Machilus japon)
ica).

The extract used in the present invention may be, for example, fresh tissue or dried material of the above-mentioned plant such as flowers, skins, fruits, leaves, roots or stems. After chopping or shredding, it is obtained by extraction with an appropriate solvent, preferably a lower monohydric or polyhydric alcohol, or an aqueous solvent thereof. Examples of the lower monohydric alcohol used for the extraction include alcohols having 1 to 3 carbon atoms, such as methanol, ethanol, propanol and isopropanol. Among them, ethanol is most preferable, but hydroalcohol (water content of 10 to 80%, preferably 30 to 70%) may be used.

The lower polyhydric alcohol includes alcohols having 2 to 4 carbon atoms, for example, ethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin and the like. Of these, 1,3-butylene glycol is most preferred, but hydrated glycol (water content of 10 to 80%, preferably 30 to 70%) may be used. The extraction operation may be performed by a known method such as a batch method or a reflux method. For example, 3 to 30 parts of an extraction solvent is added to 1 part of a dried plant (shredded). The extraction temperature may be any of room temperature and heating, for example, room temperature to 80 ° C.
It is preferable to carry out the stirring for about 1 to 10 hours in a moderate temperature range under gentle conditions. Repeat the extraction operation several times,
Liquid combined extract, or 40 ° C under reduced pressure
Concentrate or dry at the following temperature to obtain an extract. The extract of the present invention can also use a high alkaloid fraction that can be obtained according to a general method for preparing alkaloids. A hair restoration composition using reticuline as an alkaloid is described in JP-A-8-217.
No. 640.

The amount of these extracts in the hair restorer of the present invention is not particularly limited, but is usually 0.001 to 20% by weight, preferably the solid content of the extract, based on the total amount of the composition. Is 0.005 to 10% by weight. The hair restorer of the present invention can be produced according to a known method, and can be in any form applicable to the scalp, such as a liquid, a milky, or an ointment containing the above components.

Further, the hair restorer of the present invention comprises minoxidil,
Diazoxide, various antiandrogens, for example, oxendrone, 4-androstene-3,17-dione-1
Nicotinic acid and its derivatives, such as 7-cyclic ethylene ketal derivative, carboxynium chloride, vitamin E acetate, vitamin E nicotine, pantothenic acid and its derivatives, biotin, glycyrrhizic acid, glycyrrhetinic acid, Cordyceps sinensis extract, Korea Carrot extract,
Assembly extract, pepper extract, cepharanthin,
Placenta extract, ethinyl estradiol, carpronium chloride, photosensitizer, other vitamins and amino acids can be simultaneously added. Further, additives usually used for hair restoration, for example, hinokitiol, hexachlorophen, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid,
Antibacterial agents such as trichlorocarbanilide and bitionol, cooling agents such as menthol, agents such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, olive oil, squalane, liquid paraffin, isopropyl myristate Oils such as alcohols, higher fatty acids, higher alcohols, other surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water, humectants, thickeners, etc. It can be appropriately compounded within a range that does not impair.

[0012]

EXAMPLES The present invention will be described in more detail with reference to Preparation Examples, Test Examples and Examples, but the present invention is not limited thereto. Preparation Example 1 Bat moss Methanol extract A bat moss methanol extract was obtained by extracting 10 parts of methanol per 1 part of stems and leaves of bats at 80 ° C. for 2 hours.

Preparation Example 2 Fraction of bat and high alkaloid fraction The above bat and methanol extract was evaporated to dryness to obtain a bat and methanol extract.
After dissolving 0 g in 2% sulfuric acid and filtering off insolubles, extraction with ether is performed to remove acidic substances. After making the acidic aqueous layer alkaline with sodium carbonate, it is extracted with ether. The ether layer was dried over anhydrous potassium carbonate and the ether was removed to obtain 0.24 g of a high alkaloid fraction.

Preparation Example 3 Ethanol Extracts of Various Plants Bats: foliage, foliage, isoyama aoki: root, lotus: seeds, trolley mallow: stem, gunnetum: foliage, tabunoki: bark: in place of methanol according to Preparation Example 1 For 10 hours at room temperature to obtain ethanol extracts of various plants.

Test Example 1 Qualitative Test of High Alkaloid Fraction A qualitative test of the high alkaloid fraction obtained in Preparation Example 2 gave the following results. Colored orange-red by Dragendorff's reagent. As a result of TLC chromatographic analysis (adsorption layer; silica gel, developing solvent; chloroform: methanol = 4: 1), a single elliptical spot near Rf = 0.26. Water insoluble, alcohol soluble.

Test Example 2 Test for Action on Proliferation of Cultured Hair Mother Cells Mouse hair tissue was collected and hair mother cells were cultured in a serum-free medium (Tanigaki et al. (1990) Arch. Dermato.
l. Res. 282: 402-407). Preparation Examples 1-3
The extracts of various plants obtained in the above were dissolved in a medium to obtain 0.1 to 10
It was adjusted to a concentration of μg / ml. On the first day of the culture, each plant extract was added. After culturing for 6 days, the cells were detached from the dish, and the number of cells was determined. The effect of each plant extract was expressed as a relative ratio when the number of cells in a control group (a group cultured only in a serum-free medium) was 100%. Table 1 shows the results.

[0017]

Table 1 Cell number Proliferation specimen (μg / ml) Relative value (%) Acceleration rate (%) Medium alone (control group) 100-Bat (Preparation Example 1) (0.1) 145 45 (1) 152 52 (10) 150 50 Bat bat (Preparation example 2) (0.1) 16868 (1) 175 75 (10) 161 61 Isoyamaaki (Preparation example 3) (0.1) 138 38 (1) 144 44 (10) ) 159 59 Lotus (Preparation Example 3) (0.1) 121 21 (1) 140 40 (10) 148 48 Trolley mallow (Preparation Example 3) (0.1) 147 47 (1) 158 58 (10) 162 62 (Preparation Example 3) (0.1) 127 27 (1) 146 46 (10) 153 53 Taboki (Preparation Example 3) (0.1) 135 35 (1) 141 41 (10) 155 55 As is clear from Table 1, each plant extract has an excellent growth promoting effect of hair mother cells as compared with the control.

Test Example 3 Hair growth promotion test using C3H mice C8H male mice, 8 weeks old, were shaved to a size of about 2 × 4 cm, and from the next day, 50% ethanol containing 1% by weight of an ethanol extract of each plant was used. The solution was applied once a day to the shaved part for 15 days, in an amount of 0.1 ml, and the effect on hair regeneration at the site was examined. The effect of each plant extract was expressed as a relative ratio when the hair weight of the control group (the group coated with 50% ethanol) was 100%. Table 2 shows the results. In addition,
All samples were obtained according to Preparation Example 3.

[0019]

[Table 2] Hair weight Hair growth test sample Relative value (%) Acceleration rate (%) 50% ethanol (control group) 100-bat Kazura 250 150 Isoyama aoki 211 111 Hassu 240 140 Troroaoi 252 152 152 Gnetsum 237 137 Tabunoki 243 143143 Table 2 As is evident, each plant extract has a superior hair growth promoting effect compared to the control.

Example 1 A hair tonic was produced according to the following formulation by a conventional method. Ingredients Compounding amount (% W / V) Bats extract (Preparation Example 1) 5 95% ethanol 70 Solubilizer 1 (polyoxyethylene [60EO] hydrogenated castor oil) Propylene glycol 5 Perfume Trace amount Purified water Remainder Total 100

Example 2 A hair tonic was produced according to the following formulation by a conventional method. Ingredients Compounding amount (% W / V) Bats (Preparation Example 2) 1 95% Ethanol 70 Solubilizer 1 (Polyoxyethylene [60EO] hydrogenated castor oil) Propylene Glycol 5 Fragrance Trace amount of purified water Remainder Total 100

Example 3 A lotion was prepared according to the following formulation by a conventional method. Ingredients Compounding amount (% W / V) Hydroxyethyl cellulose 0.4 Ethanol 51 1,3-butylene glycol 5 Paraoxybenzoate 0.2 Isoyamaaki extract (Preparation example 3) 5 Fragrance trace amount Purified water balance Total 100

Example 4 A lotion was prepared according to the following formulation by a conventional method. Ingredients Compounding amount (% W / V) Hydroxyethyl cellulose 0.4 Ethanol 5 1,3-butylene glycol 5 Paraoxybenzoic acid ester 0.2 Trolloaoi extract (Preparation example 3) 5 Fragrance trace amount Purified water Remainder Total 100

Example 5 A hair cream was prepared according to the following formulation by a conventional method. Ingredient Compounding amount (% W / V) Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Emulsifier 4 (Polyoxyethylene [20EO] sorbitan monostearate) Paraoxybenzoate ester 0.2 Fragrance Trace amount of Gnetum extract (Preparation example 3) 5 Borax 1 Purified water Remainder Total 100

Example 6 A hair cream was produced according to the following formulation by a conventional method. Ingredients Compounding amount (% W / V) Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Emulsifier 4 (Polyoxyethylene [20EO] sorbitan monostearate) Paraoxybenzoate ester 0.2 Flavoring amount Tabanoki extract (Preparation example 3) 5 Borax 1 Purified water Remainder Total 100

[0026]

According to the present invention, according to the present invention, Menispe
Plant of the genus rmum or Cocculus, Nymphaeaceae Nelu
A composition comprising at least one extract selected from a plant belonging to the genus mbo, a plant belonging to the genus Abelmoschus, a plant belonging to the genus Gnetum and a plant belonging to the genus Machilus, has a strong hair-growth effect. And can significantly exert effects such as prevention of hair loss and promotion of hair growth.

Claims (1)

[Claims] 1. The genus Menispermum or Coc
It contains at least one selected from the extract of plants belonging to the genus culus, plants belonging to the genus Nelumbo of the waterlily family, plants belonging to the genus Abelmoschus, plants belonging to the genus Gnetum, and plants belonging to the genus Machilus. Hair restorer.