JP2003176213A - Hair grower - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair grower having high hair growing effect and also high safety with no unfavorable irritation on the scalp. <P>SOLUTION: This hair grower contains extract from Monostroma nitidum or Momordica charantia as an active ingredient. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair-growing agent, and more specifically, it has an extract of human rush or bitter gourd as an active ingredient, has an excellent hair-growing effect and does not give unfavorable irritation to the scalp. The present invention relates to a highly safe hair restorer.

[0002]

2. Description of the Related Art Alopecia is generally said to occur when the balance of the hair cycle is disturbed and the proportion of hair in the growing phase to that in the resting phase is disturbed. Examples of the cause include malnutrition of hair mother cells, autoimmunity, peripheral nerve abnormalities, mental stress, bacterial infection of the scalp, and the like, which are caused by complicated involvement of these intrinsic or extrinsic causes. It is thought to do.

[0003] Specific alopecia can be classified into resting hair loss and alopecia in which abnormally many resting hairs are lost, and growing hair loss in which atrophy hair is observed. As alopecia, androgenetic alopecia, alopecia due to dandruff or seborrheic alopecia, etc.
Alopecia areata and the like can be mentioned as an example.

[0004] A hair-growth agent is intended to improve the symptoms of hair loss and promote hair growth, and its components include a keratolytic agent on the epidermis for preventing the occurrence of dandruff on the scalp and a keratolytic agent. , A bactericidal agent to prevent bacterial growth in the scalp, a blood flow promoting agent to promote blood flow in capillaries connected to the papilla to improve blood circulation, activate hair mother cell metabolism and grow hair Various components such as a hair mother cell activator for promoting the above are used.

However, the above-mentioned conventional active ingredients are not sufficiently satisfactory in their hair-growth effect, and some of them may cause undesired irritation to the scalp and cause inflammation.

[0006]

Therefore, there is a strong demand for the provision of a hair-growth component having an excellent hair-growth effect and a high level of safety, and the present invention has found a hair-growth component satisfying the above-mentioned needs from the natural world. It is an object of the present invention to provide a hair restorer containing

[Means for Solving the Problems]

[0007] The inventors of the present invention have conducted an earnest search for the physiological actions of plants existing in the natural world.
The present invention was completed by finding that it has an excellent hair-growth effect.

[0008] That is, the present invention provides a hair-growing agent containing an extract of Astragalus orientalis as an active ingredient.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The first aspect of the hair-growth agent of the present invention is a hair-growth agent containing an extract of Human Exa. In this embodiment, the raw material for obtaining the extract, Monostroma nitidum, is a seaweed belonging to the family Astragalus, and is also called Hitoeaosa, Gingao, Bekkokoao, Betaao and the body. Is a thin film, has a wide wavy, bright green color and is flexible.
Prosperous from winter to spring, first grader about 6-15c in length
It is a seaweed that is attached to rocks and boulders and has been cultivated in Okinawa prefecture in recent years.

[0010] The human rush, which has been eaten as so-called "blue seaweed" or "ursa" since ancient times, contains abundant dietary fiber, minerals, calcium, vitamins and iron, and has a colon cancer preventive effect. It is known to have the effect of reducing cholesterol in the blood. However, there is no report on whether or not this product contains a hair-growth component.

In obtaining the extract from human Exa, all parts of human Exa can be used, and each part can be used as an extraction raw material alone or in an appropriate mixture. Moreover, as a property of the human Exa as a raw material, both dried and non-dried properties can be preferably used.

In order to obtain the extract used in the present invention from human Exa, the above-mentioned raw materials of human Exa may be shredded or crushed if necessary, and solvent extraction may be carried out by a generally used extraction method using an appropriate solvent.

The solvent used for the solvent extraction is not particularly limited, and examples thereof include water and anhydrous or water-containing organic solvents. 1 as an anhydrous or hydrous organic solvent
Examples thereof include one or more selected from a polyhydric alcohol, a polyhydric alcohol or a derivative thereof, a ketone, an ester, an ether, a petroleum ether, an aliphatic hydrocarbon or a halide, and an aromatic hydrocarbon.

Specific solvents include methanol, ethanol, isopropyl alcohol, n-propyl alcohol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octanol and the like having 1 to 8 carbon atoms. Monohydric alcohol; ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, etc.
6 polyhydric alcohol or its derivative; carbon number of 3 to 6 such as acetone, methylacetone, ethylmethylketone, isobutylmethylketone, methyl-n-propylketone
Ketone; ester having 4 to 5 carbon atoms such as ethyl acetate and isopropyl acetate; ether and petroleum ether having 4 to 8 carbon atoms such as ethyl ether, isopropyl ether and n-butyl ether; n-butane, n-pentane, Aliphatic hydrocarbons having 4 to 8 carbon atoms such as n-hexane and n-octane; Halides of aliphatic hydrocarbons having 1 to 2 carbon atoms such as carbon tetrachloride, chloroform, dichloroethane and trichloroethylene; benzene and toluene 6 to 7 carbon atoms
The aliphatic hydrocarbons and the like are exemplified, and these can be used alone or in combination of two or more. Among these, it is particularly preferable to use water or a monohydric alcohol such as methanol or ethanol.

The amount of the above-mentioned solvent used in the extraction is not particularly limited.
It is 0.1 to 1000 times by weight, preferably 1 to 100 times by weight, and more preferably 10 to 40 times by weight.

Further, the extraction method using the above-mentioned solvent can also be carried out according to a conventional method. For example, regarding the extraction temperature, extraction may be performed at a temperature of about room temperature, or extraction may be performed at a temperature near the boiling point of the solvent used. In addition, regarding the extraction operation, the dried and pulverized product of H. exa
A method of extracting by immersion for 30 days, a method of performing reflux extraction at a temperature around the boiling point of the extraction solvent, and the like can be adopted.

The second aspect of the hair restorer of the present invention is a hair restorer containing an extract of bitter melon. In this embodiment, bitter gourd (Momord
icacharantia) belongs to the genus Vorticella genus Vorticella, commonly known as Virgin (vine) or bitter melon,
It is a climbing annual grass and the petiole is about 1.5-10c in length.
m. The flowers are yellow and extend from the leaves and axilla about 2 to 1
One is attached to the tip of a 3 cm floral pattern. In the middle of the flower stem, there is a heart-shaped bract about 3 to 20 cm in length. The fruits are spindle-shaped to oval, 3 to 12 cm in length, and have intermittent peaks running vertically and covered with wart-shaped projections. The surface of the fruit becomes orange when ripe, and the soft meat that wraps the seed becomes red.

The fruits of this bitter gourd have long been known to be edible, and since the fruits contain abundant vitamin C (120 mg per 100 g), it is possible to counter the cold by eating, and the skin is glossy. It is known that the effect of giving. Further, it is known that the antioxidant effect of vitamin C contained in bitter gourd has an effect on active oxygen in the body which is increased by heat and ultraviolet rays, especially in summer. In addition, a component called charantin contained in the skin of bitter gourd lowers the blood sugar level in the blood, that is, it has an action similar to insulin, and because it is rich in potassium, it is effective in lowering blood pressure. It is known as an effect of. However, it is not known at all whether this bitter gourd contains a component having a hair-growing effect.

In obtaining the extract from bitter gourd,
All parts of bitter gourd can be used, and the respective parts such as the fruit part, the root part, the stem part and the leaf part can be used alone or in an appropriate mixture. As for the properties of bitter gourd, both dried and non-dried ones are preferably used.

The extraction solvent, extraction method, etc. used to obtain the extract from bitter gourd may be the same as in the case of human Exa, and the amount of the extraction solvent to be used is not particularly limited, but it is 0.1 for a bitter gourd
˜1000 times by weight, preferably 1 to 200 times by weight, particularly preferably 10 to 50 times by weight.

The above-mentioned extract, which is the active ingredient of the hair-growing agent of the present invention, can be used as it is or after being appropriately diluted, or can be used after further distilling off the extraction solvent. For example, when water or ethanol is used as the extraction solvent, it can be used without distilling the solvent from the extraction liquid because it is highly safe to the skin. On the other hand, when another solvent is used, the extraction solvent can be distilled off from the extract and used if necessary.

In the hair-growing agent of the present invention, the extract obtained by the above method may be further purified and the purified extract obtained may be used as an active ingredient. As the purification treatment, any method that is usually used may be used, and for example, liquid-liquid distribution, liquid column chromatography, or the like can be used. In the case of purification by liquid column chromatography, as the packing material packed in the column, ion exchange resin, alumina, silica gel, agarose gel, etc. can be used. The purification treatment by liquid column chromatography may be performed according to a conventional method.

The hair restorer of the present invention is prepared by using the extract obtained by the above-mentioned method as an active ingredient and, if necessary, combining it with an appropriate optional ingredient. The content of the extract is not particularly limited, but if it is too small, the effect of containing the component will not be sufficiently exerted, so in the case of Human Exa, the dry powder weight is 0.00
It is preferable to set it to 01 to 30% by mass, and 0.001 to 1
Mass% is more preferable, and 0.01 to 0.1 mass% is particularly preferable. In the case of bitter gourd, the dry powder weight is preferably 0.0001 to 30% by mass,
0.001 to 5 mass% is more preferable, and 0.05 to
0.5% by weight is particularly preferred.

In addition to the above-mentioned essential components, the hair restorer of the present invention also includes, as a hair restorer and hair restorer component, for example, vitamin E and its derivatives, ginseng extract, ginseng extract, methyl nicotinate, benzyl nicotinate, Blood circulation promoters such as garlic extract, cepharanthin, carpronium chloride, touki extract, acetylcholine, local stimulants such as capsicum tincture, cantharisin tincture, ginger tincture, vanillamide nonylate, keratin such as phenol, urea, salicylic acid, resorcin, lactic acid Solubilizer, placenta extract, pentadecanoic acid glyceride, pantothenyl ethyl ether, biotin, hinokitiol, linoleic acid, linoleic acid, arachidonic acid, succinic acid, citric acid, alite-in, photosensitizer No. 301 and other metabolic activators, glycyrrhizic acid and its Invitation Body, diphenhydrazine hydrochloride, hydrocortisone, chlorpheniramine arylate, anti-inflammatory agent such as glycyrrhetinic acid, orthomethoxycinnamaldehyde, methyl paraoxybenzoate, ethyl paraoxybenzoate, isopropylmethylphenol, sorbic acid, benzalkonium chloride, isopropyl Methylphenol, triclosan, zinc pyrithione, hinokitiol, and other fungicides, menthol, peppermint oil, camphor, and other cooling agents, as well as estriol, estrone, estradiol, ethinyl estradiol, and other female hormones, etc. should be added as appropriate for the purpose. You can

Further, monohydric alcohols such as ethanol, n-propanol, isopropanol, and phenoxyethanol, and polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, glycerin, diglycerin, and dipropylene glycol may be used as long as the effects of the present invention are not impaired. Polyhydric alcohol, water-soluble polymer, antioxidant,
pH adjusters, UV inhibitors, sequestering agents, thickeners, surfactants, purified water, fragrances, preservatives, antibacterial agents, oils and waxes, higher fatty acids, sterols, fatty acid esters, moisturizers, cooling agents , Ordinary cosmetic ingredients such as pigments, or hormones, vitamins, amino acids, astringents and placenta extracts, elastin, collagen, mucopolysaccharides, aloe extract, loofah water, royal jelly, birch, carrot extract, chamomile extract, Special blending components such as animal and plant extract components including crude drug components such as licorice extract, salvia extract, altea extract, yarrow extract and the like can be appropriately blended according to the purpose.

The hair-growing agent of the present invention thus obtained can be used as a cosmetic, a quasi drug or a drug,
For example, it can be used as a hair tonic, hair cream, ointment, hair treatment, hair liquid, hair lotion, shampoo, and conditioner.

[0027]

EXAMPLES The present invention will be described in detail below with reference to examples and test examples, but the present invention is not limited to these examples.

Examples 1 to 5 Preparation of Ethanol Extract of Human Exa: 50 g of ethanol was added to 2 g of dried human Exa and shaker (RECIPRO SHAKER: TAI) was added.
Using TEC), the number of shaking was 290 times / minute, and the shaking extraction was performed for 2 hours. About this extract,
After centrifugation at 15000 rpm for 15 minutes, the obtained supernatant was filter-sterilized (0.45 μm) and stored at 4 ° C.

This ethanol extract of human Exxa
After diluting with 00% ethanol, sample culture solution (Assay
Medium) ^{* 1)} , diluted 10000 times, 300 times
Five kinds of diluted solutions of 0 times, 1000 times, 300 times and 100 times (in order, the diluted solutions of Examples 1 to 5) were prepared. The final concentration of ethanol was 1 in all dilutions.
%.

Note 1: Sample culture medium (Assay Medium); MC
In DB153 medium, 5 μg / mL insulin, 10
μg / mL transferrin, 5 ng / mL epidermal growth factor (EGF), 3
Prepared by adding 5 μg / mL bovine pituitary extract, 0.5 μg / mL hydrocortisone, 6.1 μg / mL ethanolamine, 14 μg / mL o-phosphorylethanolamine.

Test Example 1 Activity Measurement of Human Exa Extract on Hair Follicle Epithelial Cells: (1) Separation of hair follicle epithelial cells: C3H / HeN at 5 days of age
The skin of the newborn mouse was collected aseptically. Using a surgical knife, cut a mouse skin piece into a strip with a width of about 2 mm,
Dispase (dispase; 500 U / mL) (combined liquor purification) / 5% Fetal Bovine Serum (FBS) (CELL
CULTURE TECHNOLOGY) -Dulb
ecco's Modified Eagle's Medium (DMEM) (SIG
It was dipped in a liquid (manufactured by MA) and allowed to stand at 4 ° C. for 16 hours. After standing, the epidermis was peeled off from the skin piece using tweezers to obtain only the dermal tissue. The obtained dermis tissue was finely cut using scissors under the eye, and 0.2% of collagenase (collagen
ase) (manufactured by Nitta) / DMEM culture solution and digested at 37 ° C. for 1 hour. This dermal digestive fluid was centrifuged at 1000 rpm for 5 minutes to remove the supernatant, and then Phosphate-Buff
Ered Saline (PBS) (-) was added and gently pipetted to give a dermal suspension. Since dermal fibroblasts were removed from this dermal suspension and only the hair bulb was isolated, 1
It was allowed to stand for 5 minutes to precipitate only the hair bulb. This "stationary →
The operation of "precipitation" was performed three times. The obtained hair bulb is 0.25
% Trypsin / 2.65 mM Ethylenedia
mine-N, N, N ', N'-tetraacetic acid, disodium salt, dihy
The cells were immersed in a drate (EDTA) solution and treated at 37 ° C. for 5 minutes to disperse the cell population forming hair globules. The cell dispersion solution was centrifuged at 1000 rpm for 5 minutes, and the supernatant was removed after centrifugation. After removing the supernatant, a culture medium for cell separation (Culture Medium) ^{Note 2)} was newly added to disperse the hair follicle epithelial cells, and the cells were seeded on collagen-coated 96-well microflate (Biocoat: BD). 5% C
Incubated with O ₂ at 37 ° C.

Note 2: Culture medium for cell separation (Culture Mediu
m); was prepared by adding 10% FBS / and 1% penicillin / streptomycin (15140-122 / GIBCO) to a DMEM (D-5523: SIGMA) medium.

(2) Cell proliferation test: 24 hours after seeding the cells in the above (1), a culture medium for cell separation (Culture)
Medium) was removed and the cultured cells were washed with MCDB153 solution. To the cultivated cells, 100 μL / well of the preparations of Examples 1 to 5 were added and cultivated at 37 ° C. in 5% CO ₂ . Four days later, WTS-8 (341-07761:
Dojindo Laboratories) was added at 10 μL / well, and again 5%
Incubated in CO ₂ at 37 ° C. As a control, 1
% Ethanol aqueous solution (100% ethanol: sample medium of Assay 1 (Assay Medium) = 1: 99) and as a comparison,
A 300 μM solution of minoxidil was used. Two hours later, a microplate reader (MTP-30: CORONA
Absorbance (Measurement wavelength:
(450 nm, reference wavelength: 630 nm) was measured to evaluate the number of cells.

In the evaluation, the ratio with respect to the control was calculated as a percentage, and the results were compared with Examples 1 to 5 and comparison (minoxidil 300 μm).
The degree of cell proliferation in M) was calculated as the average of cell proliferation ratios ± standard deviation (n = 3). The test was performed by Dunnett's multiple comparison test (Super ANOVA V.1.1.
1: Abacus Concepts Inc. ), And if the risk rate was less than 5% (p <0.05), it was determined that there was a significant difference. The results are shown in Fig. 1.

As shown in the results of FIG. 1, the comparative minoxidil 300 μM group increased the cell number by about 1.6 times as compared with the control group, and a significant difference (p <0.01) was observed. It was In addition, the sample containing the extract of Human Exa increased the number of cells depending on the concentration of the extract, 1000 times, 30 times.
A significant difference was observed at 0-fold and 100-fold (10
00 times and 300 times: p <0.05, 100 times: p <
0.01). From these results, it was concluded that the growth of mouse hair follicle epithelial cells depending on the concentration of the stock solution was observed in the ethanol extract of human Exa, and that the extract of Human Exa had a hair growth promoting action. Furthermore, since the maximum activity of this diluted solution was higher than that of minoxidil used as a comparison, it was judged that when the product was developed as a hair-growth agent, it was more effective than minoxidil.

Examples 6 to 8 Preparation of hot water extract of bitter melon: 20 g of dried bitter melon,
It was immersed in 400 mL of MilliQ water (manufactured by Millipore) and boiled at 100 ° C. for 30 minutes. 1000 this
After centrifugation at 0 rpm for 15 minutes, the obtained supernatant was filter-sterilized (0.22 μm) and stored at 4 ° C.

This extract was diluted with MilliQ water and then further diluted with the above-mentioned sample culture solution of Note 1, to give 300
Three-fold, 100-fold and 30-fold dilutions (in order, the dilutions of Examples 6 to 8) were prepared. 30 times, 100
The final concentrations of MilliQ water in fold and 300 fold dilutions were 3%, 1% and 1%, respectively.

Test Example 2 Measurement of activity of bitter melon extract on hair follicle epithelial cells: Using the same method as in Test Example 1, "(1) Separation of hair follicle epithelial cells" and "(2) Cell proliferation test" The dilutions prepared above in Examples 6-8 and 1% Milli as control
Q water aqueous solution (Milli Q water: Note 1 sample culture solution (Assa
y Medium) = 1: 99), the absorbance was measured in the same manner as in Test Example 1, and the numbers of cells were compared and evaluated.

In the evaluation, as in Test Example 1, the ratio with the control was calculated as a percentage, and the cell proliferation rate of Examples 6 to 8 was calculated as the average value of cell proliferation ratio ± standard deviation (n = 6). did.
The test is performed by Dunnett's multiple comparison test (Super
ANOVA V. 1.11: Abacus Conce
pts Inc. ), The risk rate is 5% (p <0.
When it was less than 05), there was a significant difference. The results are shown in Figure 2.

As shown in the results of FIG. 2, the comparative minoxidil 300 μm group had a 1.2-fold increase in the number of cells as compared with the control group, and a significant difference (p <0.01) was observed. . The dilution containing the extract of bitter gourd increases the number of cells depending on the concentration of the extract, and the dilution concentration is 100 times, 3 times or more.
A significant difference was observed at 0 times (both p <0.0.
1). From these results, it was concluded that the growth of mouse hair follicle epithelial cells in the ethanol extract of bitter gourd was dependent on the concentration of the stock solution, and that the bitter gourd extract had a hair growth promoting action. Further, the maximum value of the activity of this diluted solution was higher than that of minoxidil used as a comparison, and therefore, when the product was developed as a hair-growing agent, it was judged to be more effective than minoxidil.

Example 9: Hair liquid A hair liquid was produced by a conventional method with the following formulation.

[0042]   (Direction)       Component mass%     1. Diluent obtained in Example 5 0.1     2. Ethanol 40     3. Glycerin 1     4. Fragrance suitable amount     5. Purified water Remaining amount

Example 10: Hair liquid A hair liquid was produced by a conventional method with the following formulation.

[0044]   (Direction)       Component mass%     1. Diluent obtained in Example 8 0.1     2. Ethanol 40     3. Glycerin 1     4. Fragrance suitable amount     5. Purified water Remaining amount

Example 11: Hair shampoo A hair shampoo was produced by a conventional method with the following formulation.

[0046]   (Direction)       Component mass%     1. Diluent obtained in Example 5 0.1     2. Sodium lauryl ether sulfate ethanol 20     3. Sodium lauryl sulfate 10     4. 1,3 butylene glycol 1     4. Fragrance suitable amount     5. Purified water Remaining amount

Example 12: Hair shampoo A hair shampoo was produced by a conventional method with the following formulation.

[0048]   (Direction)       Component mass%     1. Diluent obtained in Example 8 0.1     2. Sodium lauryl ether sulfate ethanol 20     3. Sodium lauryl sulfate 10     4. 1,3 butylene glycol 1     4. Fragrance suitable amount     5. Purified water Remaining amount

Example 13 Hair Cream A hair cream was produced by a conventional method with the following formulation.

[0050]   (Direction)       Component mass%     1. Diluent obtained in Example 5 0.1     2. Liquid paraffin 5     3. Vaseline 2     4. Cetostearyl alcohol 1     5. Methyl polysiloxane 1     6. Methyl paraoxybenzoate 0.2     7. Propylene glycol 5     8. Fragrance suitable amount     9. Purified water Remaining amount

Example 14: Hair Cream A hair cream was produced by a conventional method with the following formulation.

[0052]   (Direction)       Component mass%     1. Diluent obtained in Example 8 0.1     2. Liquid paraffin 5     3. Vaseline 2     4. Cetostearyl alcohol 1     5. Methyl polysiloxane 1     6. Methyl paraoxybenzoate 0.2     7. Propylene glycol 5     8. Fragrance suitable amount     9. Purified water Remaining amount

The hair liquids, hair shampoos and hair creams of Examples 9 to 14 were all excellent in hair growth effect. Further, it was safe without giving any unpleasant irritation to the scalp.

[0054]

EFFECTS OF THE INVENTION The hair-growing agent of the present invention contains an extract of H. nigrum or bitter melon and has a hair follicle cell proliferating activity, and therefore activates hair follicles to exert an excellent hair-growing effect. be able to. Moreover, it is safe without giving any unfavorable irritation to the scalp.

Therefore, the hair nourishing agent of the present invention can be used as a cosmetic, a quasi drug, or a drug.
It effectively acts as a hair tonic, a hair cream, an ointment, a hair treatment, a hair liquid, a hair lotion, a shampoo and a conditioner.

[Brief description of drawings]

FIG. 1 is a graph showing the cell proliferation degree of human Exa in test example 1 (control is taken as 100%).

FIG. 2 is a graph showing the degree of cell growth of bitter gourd in Test Example 2 (control is taken as 100%). that's all

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Shuichi Oka             1-1-1 Higashi 1-1-1 Tsukuba City, Ibaraki Prefecture             Inside the Tsukuba Center, National Institute of Advanced Industrial Science and Technology (72) Inventor Akira Tsuruta             1-1-1 Higashi 1-1-1 Tsukuba City, Ibaraki Prefecture             Inside the Tsukuba Center, National Institute of Advanced Industrial Science and Technology (72) Inventor Koori Yamamoto             1-1-1 Higashi 1-1-1 Tsukuba City, Ibaraki Prefecture             Inside the Tsukuba Center, National Institute of Advanced Industrial Science and Technology (72) Inventor Masahiko Inami             5-1 Kyushuzaki, Gushikawa City, Okinawa Prefecture             Inside the Tropical Techno Center (72) Inventor Hirozo Tamura             5-1 Kyushuzaki, Gushikawa City, Okinawa Prefecture             Inside the Tropical Techno Center (72) Inventor Toshikatsu Higa             5-1 Kyushuzaki, Gushikawa City, Okinawa Prefecture             Inside the Tropical Techno Center (72) Inventor Yasuhiro Kamata             12-2 Kyushuzaki, Gushikawa City, Okinawa Prefecture Okinawa Industry             Inside the technical center (72) Inventor Tetsuya Toyokawa             12-2 Kyushuzaki, Gushikawa City, Okinawa Prefecture Okinawa Industry             Inside the technical center F term (reference) 4C083 AA111 AA112 AC012 AC022                       AC072 AC102 AC122 AC342                       AC782 AD152 CC37 CC38                       DD23 DD27 DD31 EE10 EE12                       EE22                 4C088 AA12 AB19 AC04 AC05 AC11                       AC15 BA08 CA03 MA17 MA28                       MA63 NA14 ZA92

Claims (3)

[Claims] 1. A hair restorer containing, as an active ingredient, an extract of human rush (Monostroma nitidum) or an extract of bitter melon (Momordica charantia). 2. The hair restorer according to claim 1, wherein the dry extract contains the human Exa extract in an amount of 0.0001 to 30 mass% with respect to the entire hair restorer. 3. The hair restorer according to claim 1, which contains 0.0001 to 30 mass% of the bitter melon extract as a dry weight thereof based on the entire hair restorer.