KR20160116721A - Composition for prevention of hair loss or promotion of hair growth containing assam extract and/or isodon japonicus extract - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss or promoting hair growth, comprising an Assam tea extract, an Isodon japonicus extract, or a mixture thereof. The composition for preventing hair loss or promoting hair growth of the present invention prevents the death of follicular cells and skin epithelial cells due to the oxidation of sebum by inhibiting neutral fat secreted from the sebaceous gland of the follicles, and exhibits effects in preventing hair loss or promoting hair growth by improving the scalp condition.

Description

[0001] The present invention relates to a composition for prevention of hair loss or promotion of hair growth comprising an extract of Asami and /

The present invention relates to a composition for promoting hair loss prevention or hair growth, which comprises an extract of Acanthamoeba, an extract of Agrobacterium tumefaciens, or a mixture thereof.

Along with the recent increase in social stress, the hair loss population is gradually increasing due to westernized eating habits such as environmental pollution and instant food, frequent perm and dyeing. The cycle of hair consists of anagen which grows hair, catagen which is the period of termination of growth and reduction of the size of the moles, taloge which is the period when the papilla stops its activity and keeps its hair on the scalp, Or a generator that generates new hair to depilate old hair.

The Anagen Stage (2-7 years) is the period of hair growth, divided into hair growth stages where the hair is going to go out from the hair to the blanket and the stage where the hard keratin is made inside the hair follicle. Hair continues to self-grow until the retrogressive.

Catagen Stage (2 to 3 weeks) is the period when the metabolic process is slowed down at the end of the growing season, maintaining the shape of the hair, and does not produce keratin at this stage. Degenerators account for 1% of total hair. At this time, the mothers shrink and divide into the dermal papilla, surrounded by the hair follicles and go upwards, and the cell division is stopped. The Talogen Stage (3 months) shrinks the papillary, the hair follicles shrink gradually, and the hair follicles are pushed upwards and fall out. The lifespan of the hair until the next stage of growth begins is 3 to 4 months.

People with normal hair have a lot of hair growing, but people with alopecia (Alopecia) have a lot of hair in their resting state. As hair loss progresses, the period of growth is shortened and hair becomes smaller and smaller. Therefore, in order to treat hair loss, it is important to allow the hair follicle in a resting state to rapidly grow and to shorten the growth period.

Male alopecia are caused by testosterone, a testosterone that is converted to a more powerful hormone, Dihydrotestosterone (DHT), by an enzyme called 5α-reductase. Hormone acts on the hair follicle to induce the hair follicle from the growing stage to the regenerator stage to cause hair loss. Therefore, a method of inhibiting the production of DHT by 5 alpha-reductase in order to treat male alopecia is mainly used.

Female alopecia are caused mainly by a decrease in the amount of estrogen after menopause. Minoxidil and estrogen are mainly used as therapeutic agents for female alopecia.

Alopecia areata is caused by autoimmune diseases, mental stress, genetic predisposition. These alopecia areata are fundamentally different from those of androgenetic alopecia, and different methods of treatment are used, either by a method of treating corticosteroids, or by applying minoxidil to the affected area or artificially inducing a stimulus to the affected area.

As a result, it has been known that there are no known effects on hair loss caused by various complications, such as blood circulation promotion, suppression of male hormone function, hair follicle enhancement, etc. However, . For example, minoxidil has been reported to cause sticky sensation and side effects that cause irritation to the skin. Pinastaride is currently used as a preparation for oral administration, but adverse effects such as sexual dysfunction have been reported depending on its consumption, There was a lot of inconvenience to use because it was expected to be effective only by oral administration.

In addition, although many substances have been reported to exhibit hair loss treatment or hair growth effect, it has been reported that prevention of sebum oxidation by suppressing the triglyceride secreted from the hair follicle and the skin epithelial cell death due to sebum oxidation, The development of a product that effectively prevents hair loss by preventing the death of the hair is very limited. In addition, there is an urgent need to develop products for preventing or treating hair growth, wool or hair loss, which are not only safe and effective to the living body but also stable and economical to manufacture.

Assam is a tea made in Assam province, which boasts the most tea production in India. It is the name of Indian native black tea cultivated by British in 1823. The Assam Black tea originated from the native trees of Assam, India, and became known to the world in 1823 by Major British soldier Robert Bruce. The tree that Bruce discovered was a large tree that grew to a height of 12m. The leaves are about 20cm long, about 4cm wide, pointed end, and much larger than ordinary trees. It is suitable for making black tea because it contains a lot of tannins. It also makes tea varieties for tea by breeding with Japanese and Chinese tea trees. It is currently being cultivated on a large scale in countries such as India, Sri Lanka, Indonesia, and Kenya as well as the African East Coast. It is a blend of intense flavor, malt flavor and deep red color. Because it has strong taste and flavor, it is mainly used as a blending base material such as English breakfast and milk drink.

Isodon japonicus (Burm.) Hara) is a perennial herb in the mountains and fields of each country. The growth environment is slightly dry and grows in sunny or semi-dark. Its height is 50-100㎝. Leaves face opposite to each other. Its length is 6 ~ 15㎝, width is 3.5 ~ 7㎝ wide egg-shaped, and its tip is pointed. The surface of the leaf is green and the back side is light green, with fine hairs and sawtooth on the edge. The flower is light purple, about 0.5 ~ 0.7㎝ long, and faces the axil and the end of the main stem. Fruits run oval in October. It is used for edible use, and for medicinal purposes.

Japanese Patent Application Laid-Open No. 2009-212634 discloses an anti-aging composition including an extract of Fenugreek, and Korean Patent Laid-Open Publication No. 2014-0109631 discloses an antioxidant activity of Fenugreek extract. However, There is no document which describes the effect of preventing the hair loss or accelerating the hair growth of the extract of Asan or Radix extract.

Accordingly, the present inventors have made intensive efforts to find a substance that is harmless to the human body, prevents hair loss, and effectively promotes the growth of hair. As a result, it has been found that a composition containing Asami extract, Thereby improving the scalp condition, preventing hair loss, and allowing hair follicles to grow well, thus completing the present invention.

It is an object of the present invention to provide a composition which contains an extract of Asami, an extract of Panax ginseng, or a mixture thereof as an active ingredient, thereby suppressing sebum oxides and improving the scalp state, thereby preventing hair loss or promoting hair growth.

In order to achieve the above object, the present invention provides a composition for promoting hair loss prevention or hair growth comprising an extract of Acanthopanax senticosus, Radix extract, or a mixture thereof as an active ingredient.

The composition for preventing hair loss or hair growth of the present invention inhibits the triglyceride secreted from the hair follicle line to prevent skin epithelial cells and hair follicle cell death due to sebum oxidation and improves the scalp state to prevent hair loss or promote hair growth . In addition, it is excellent in stability to the skin and has no side effects, and can be widely used in external preparations for skin, cosmetic compositions, and pharmaceutical compositions.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

In one embodiment of the present invention, it was confirmed that when the hair follicle cells were treated with a mixture of Assam extract, Radix extract, or Assam extract and Radix extract, the number of hair follicle cells proliferated remarkably and the hair follicle length was grown Respectively.

Accordingly, the present invention relates to a composition for preventing hair loss or promoting hair growth comprising an extract of Acanthamoeba sp., Radix Herba extract, or a mixture thereof as an active ingredient.

Assam is a tea made in Assam province, which boasts the most tea production in India. It is the name of native varieties of black tea in India. It is grown in Camellia Sinensis (Indian subspecies), and the tea tree is a large tree with a length of about 20cm, a width of about 4cm, a pointed end, . It is suitable for making black tea because it contains a lot of tannins. It also makes tea varieties for tea by breeding with Japanese and Chinese tea trees. It is a mixture of intense flavor, malt flavor and deep red color. It is characterized by strong taste and flavor.

Isodon japonicus (Burm.) Hara) is a perennial herb in the mountains and fields of each country. The growth environment is slightly dry and grows in sunny or semi-dark. Its height is 50-100㎝. Leaves face opposite to each other. Its length is 6 ~ 15㎝, width is 3.5 ~ 7㎝ wide egg-shaped, and its tip is pointed. The surface of the leaf is green and the back side is light green, with fine hairs and sawtooth on the edge. The flower is light purple, about 0.5 ~ 0.7㎝ long, and faces the axil and the end of the main stem. Fruits run oval in October. It is used for edible use, and for medicinal purposes.

There are many causes of hair loss, but it is also caused by triglycerides (sebum) secreted from the hair follicles. Although sebaceous glands are secreted through the hair follicle line to form a thin film on the scalp to protect the scalp, the excess sebum induces scalp itching and inflammation, and skin epithelium and hair follicle cells are killed due to sebum oxidation, To the regressor to induce hair loss. The extract of Asam or Acanthamoeba extract of the present invention not only prevents hair loss by suppressing sebaceous oxide to improve the scalp state, but also shortens the period of transition from dormant period to growing period, promotes hair growth, It helps to grow.

In the present invention, the Assam extract may be contained in an amount of 0.01 to 50% by weight based on the total weight of the composition, and the extract of Radix Salvia may be contained in an amount of 0.01 to 50% by weight based on the total weight of the composition. have. If it is less than 0.01% by weight, sufficient hair growth promoting effect can not be obtained. If it exceeds 50% by weight, safety and formulation stability may be lowered.

In addition, the extracts of Assam and Nascentrum can be mixed in various combination ratios such as 1: 1 to 1: 5, 1: 1 to 5: 1, and contained in the composition of the present invention.

In the present invention, the composition may further comprise at least one selected from the group consisting of ginseng extract, pine needle extract, green tea extract, and Rhodiola extract. Ginseng extract, pine leaf extract, green tea extract, and garlic extract also have an effect of inhibiting oxidation of sebum secreted from hair follicles to reinforce the scalp and prevent hair loss. The extracts of Asami, When added to a mixture of the grass extract, the effect of preventing hair loss and promoting hair growth can be further enhanced.

In the present invention, the composition is at least one type of formulation selected from the group consisting of hair tonic, hair nutrition lotion, hair essence, hair serum scarf treatment, hair treatment, hair conditioner, hair shampoo, and hair lotion .

In addition, the composition for promoting hair growth and hair growth according to the present invention can be formulated into, for example, a pharmaceutical composition, a cosmetic composition, a composition for external application for skin, or an oral composition for a health food composition.

The pharmaceutical composition for promoting hair growth and hair growth according to the present invention may further contain a preservative, a stabilizer, a wetting agent or an emulsifying accelerator, a pharmaceutical adjuvant such as a salt and / or a buffer for controlling osmotic pressure, and other therapeutically useful substances And may be formulated into various oral or parenteral dosage forms according to conventional methods.

Examples of the oral administration agent include tablets, pills, hard and soft capsules, liquids, suspensions, emulsions, syrups, powders, powders, granules, granules and pellets, , Diluents (such as lactose, dextrose, sucrose, mannitol, sorbitol, cellulose and glycine), lubricants (such as silica, talc, stearic acid and magnesium or calcium salts thereof and polyethylene glycols). The tablets may also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and polyvinylpyrrolidine, optionally mixed with starch, agar, alginic acid or its sodium salt Such as disintegrants, absorbents, coloring agents, flavoring agents, and sweetening agents. The tablets may be prepared by conventional mixing, granulating or coating methods. In addition, it may be a transdermal dosage form in the form of parenteral administration. For example, it may be in the form of injections, drops, ointments, lotions, gels, creams, sprays, suspensions, emulsions, suppositories, But is not limited thereto.

The pharmaceutical composition according to the present invention can be administered by parenteral, rectal, topical, transdermal, subcutaneous, and the like. The pharmaceutical composition according to the present invention can be administered topically to, for example, the scalp.

The dosage of the active ingredient is within the level of those skilled in the art, and the daily dose of the drug depends on various factors such as the degree of symptom progression, age, health condition, and complications of the subject to be administered. As a standard, it is generally possible to administer the composition at a dose of 1 / / kg to 200 mg / kg, preferably 50 / / kg to 50 mg / kg, once or twice a day, Are not intended to limit the scope of the present invention.

The composition for promoting hair growth and hair growth according to the present invention may be a cosmetic composition, and the external form of the cosmetic composition contains a cosmetically or dermatologically acceptable medium or base. It may be in any form suitable for topical application, for example, as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing an oil phase in water, a suspension, a microemulsion, a microcapsule, In the form of ionic fibrin dispersions, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The composition for promoting hair growth and hair growth according to the present invention can be formulated in the form of shampoo, hair treatment, scarf treatment, hair essence, hair pack, hair cream, hair tonic, general ointment and the like.

When the formulation of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

In the case of the solution or emulsion of the present invention, a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

The composition of the present invention may further contain, in addition to the above-described components, a functional additive and components contained in a general scalp or hair composition. The functional additives may include water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymeric polysaccharides, sphingolipids and seaweed extracts.

The cosmetic composition of the present invention may further contain, in addition to the above-described functional additive, components contained in a general cosmetic composition as required. Examples of the other ingredients that can be included in the composition include humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbents, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, Accelerators, coolants, antiperspirants, purified water, and the like.

In addition, the composition of the present invention may be in the form of a health food composition. In the health food composition of the present invention, the composition may be in a liquid or solid form and may be in the form of tablets, capsules, soft capsules, pills, granules, beverages (drinks), diet bars, chocolates, And the formulation is not particularly limited. In the health food composition of the present invention, the health food composition may contain excipients, saccharides, fragrances, pigments, oils, proteins and the like as needed in addition to the active ingredients.

In addition, the composition of the present invention may contain a skin absorption promoting substance to increase the hair growth promoting effect.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments. It is therefore intended that the scope of the invention be defined by the claims appended hereto and their equivalents.

[Example 1] Preparation of Assam extract

10 kg of tea leaf of Assam main tea was collected and dried for 3 days in a constant temperature drier (20 ° C.) so that the moisture content of the dried product was less than 8% (wt / wt). Then, the dried grass leaf was put into a grinder and crushed into 18 mesh. Then, 5 L of purified water was added thereto, followed by stirring at 38 to 42 ° C in hot water for 24 hours, followed by immersion for one day at 15 ° C. Thereafter, the residue and filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 540 g of the extract.

In the following Test Example, Camellia sinensis extract prepared by the above method was purchased from Bioland nature (science & Life).

[Example 2] Preparation of extracts

10 kg of eggplant paste was sampled and dried in a constant temperature drier (20 ° C.) for 3 days so that the moisture content on the dry matter basis was 8% (wt / wt) or less. Thereafter, the dried flower buds were pulverized into 18 mesh, and 5 liters of purified water was added thereto. The resulting mixture was stirred for 24 hours at 38 to 42 ° C in hot water, and then immersed at 15 ° C for 1 day. Thereafter, the residue and filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 540 g of the extract.

In the following Test Example, Isodon japonicus (Burm.) Hara prepared by the above method was purchased from Bioland nature, science & Life.

[Example 3] Preparation of a mixture of Assam extract and Radix extract

The AAsam extract prepared in Example 1 and the ginger extract prepared in Example 2 were mixed at a weight ratio of 1: 1 to obtain a 1.08 kg mixture.

[Test Example 1] Follicular cell proliferation test (MTT analysis)

1. Isolation / culture of dermal papilla cells

A 26 - year - old woman with hair loss symptoms underwent a hair transplantation procedure, and scalp tissue was obtained. The dermal papilla cells were separated from the scalp tissues using a microscope and cultured for 14 days in collagen type I coated 35 mm culture dishes (BD Biosciences, San Diego, Calif., USA). (Gibco, NY, USA), 100 U / ml penicillin (Gibco, NY, USA) and 20% heat-inactivated fetal bovine serum (FBS, Lonza, Walkersville, MD) as the culture medium Dulbecco's modified Eagle's medium (DMEM; Gibco BRL, Gaithersburg, MD) (5% CO ₂ , 37 ° C) was used.

When cells were 80% confluent, cells were collected using 0.25% trypsin / 10 mM EDTA (Gibco, NY, USA) and cultured in DMEM medium supplemented with 10% FBS.

2. Culture for growth of dermal papilla cells

Dermal papilla cells were seeded in 96-well plates (Nunc, Wiesbaden, Germany) at 2000 seeds per well and cultured for 24 hours (5% CO ₂ , 37 ° C). Then, 10 μM treatment of only 10 μM treatment of only the assam extract (Example 1) or the scutellariae extract (Example 2), or a 1: 1 mixture of the assas extract and scutellariae extract (Example 3) was carried out and further cultured for 96 hours . For comparison, the control group was cultured without treatment of either Acasanthus extract or Radix grass extract.

3. Cell proliferation measurement

(70 μg / well) of MTT (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide; Sigma, St Louis, MO) was added to each well of a 96- And cultured for 3 hours. Then, the absorbance was measured at 570 nm by adding 100 μl of DMSO (dimethyl sulfoxide; Sigma, St Louis, MO) to each well (ELISA Reader). As a result, the control group to which no extract of Asam or the extract of Panax notoginseng was added was taken as 100 and the relative value thereof was calculated.

In the case of treatment with either the extract of Asam or the extract of Nympumula, the papilla cells proliferate by about 50% when treated with the Assam extract or the Nympumarum extract. When the Assam extract and Nympumarum extract are treated simultaneously, these two components And that the proliferation of the dermal papilla cells was improved by 100% or more.

[Test Example 2] Follicular organ culture (evaluation of hair follicle growth length)

1. Human hair follicle separation

A 26 - year - old woman with hair loss symptoms underwent a hair transplantation procedure, and scalp tissue was obtained. The hair follicle samples were separated from the scalp scalp tissue using a microscope. At this time, 6 groups of follicular samples (ie, 90 samples) were divided into 15 groups for experimental application.

2. Follicular cultivation

500 [mu] l of the culture medium was dispensed into a 24-well plate (Nunc, Wiesbaden, Germany) and then 5-6 samples were cultured per well. (Gibco, NY, USA), 10 μg / ml insulin, 10 ng / ml hydrocortisone (Sigma, St Louis, MO) William's E medium (Gibco, NY, USA) containing 10 [mu] g / ml streptomycin, 100 U / ml penicillin (Gibco, NY, USA) was used. Then, a 1: 1 mixture (Example 3) of 10 ppm of lipid peroxide and 50 ppm of Assam extract (Example 1), 10 ppm of lipid peroxide and 50 ppm of Radix grass extract (Example 2), 10 ppm of lipid peroxide, 50ppm, respectively, and cultured for 3 days while changing medium every 2-3 days. For comparison, only 10 ppm of lipid peroxide was treated in the control group.

3. Growth length measurement

The hair follicles were photographed using a stereomicroscope (Dongwon CNS, Korea), and the growth length was measured on the 3rd and 6th days using the Image J program.

The degree of hair growth was significantly increased in the case of treatment with the extract of Asan and Radix extract compared to the case of neither the extract of Asan and the extract of Radix extract. Especially, when the extract of Asan and Radix extract was treated at the same time, It was confirmed that the degree of hair growth was improved by 100% or more due to the synergistic action of the components.

[Formulation Example 1] Hair tonic

A hair tonic was prepared according to a conventional method according to the composition shown in Table 1 below.

ingredient Weight ratio (%) ethanol 50 menthol 0.02 glycerin 3 Salicylic acid 0.05 Assam extract, Radix grass extract, or a mixture thereof 2.0 Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 2] Hair lotion

Hair lotions were prepared in a conventional manner according to the composition shown in Table 2 below.

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 EDTA 2Na 0.2 Hydroxyethyl cellulose 0.5 Mineral oil 5.0 Assam extract, Radix grass extract, or a mixture thereof 2.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 3] Hair nutritional lotion

The hair nutritional lotion was prepared according to a conventional method according to the composition shown in Table 3 below.

ingredient Weight ratio (%) Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Mineral oil 10.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Assam extract, Radix grass extract, or a mixture thereof 2.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 4] Hair shampoo

Hair shampoos were prepared in a conventional manner according to the composition shown in Table 4 below.

ingredient weight% Purified water Balance (To 100) Assam extract, Radix grass extract, or a mixture thereof 2.0 Sodillauryl sulphite 36.0 Cocamidopropyl betaine 8.0 Palmitidine dimalate 2.0 Glycollosteralate 1.5 Polyquaternium 10 0.5 Saitric Acid 0.1 glycerin 2.0 Preservatives, coloring and flavoring Suitable amount

[Formulation Example 5] Hair rinse

Hair rinses were prepared according to the compositions shown in Table 5 below by a conventional method.

ingredient weight% Purified water Balance (To 100) Assam extract, Radix grass extract, or a mixture thereof 2.0 Propylene glycol 2.0 Cetyltrimethylammonium chloride 1.0 Cetyl alcohol 3.0 Stearyl alcohol 3.0 Mineral oil 0.5 Saitric Acid 0.2 Polydimethylsiloxane 1.0 Preservatives, coloring and flavoring Suitable amount

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (5)

A composition for preventing hair loss or promoting hair growth comprising an extract of Assam, an extract of Panax ginseng, or a mixture thereof as an active ingredient. [3] The composition for preventing hair loss or hair growth of claim 1, wherein the extract is in an amount of 0.01 to 50% by weight based on the total weight of the composition. [2] The composition according to claim 1, wherein the extract is present in an amount of 0.01 to 50% by weight based on the total weight of the composition. [2] The composition according to claim 1, wherein the composition further comprises at least one selected from the group consisting of ginseng extract, pine needle extract, green tea extract, and Rhodiola extract. 6. The composition according to any one of claims 1 to 5, wherein the composition is selected from the group consisting of hair tonic, hair nutritional lotion, hair essence, hair serum scarf treatment, hair treatment, hair conditioner, hair shampoo, Wherein the composition is one or more formulations selected from the group consisting of: