KR101189838B1 - Composition for improving condition of hair and scalp containing fermented plant extracts - Google Patents

Abstract

The present invention relates to a composition for improving the condition of hair and scalp containing fermented herbal extract, and more particularly, at least one fermentation selected from the group consisting of camphorol and isoflavone obtained by fermenting and extracting green tea and soybean in a gel-type formulation. The present invention relates to a composition for improving the condition of hair and scalp by reducing the stimulation of the scalp by promoting the induction from the resting phase to the growing hair cycle and maintaining the growing hair cycle for a long time, thereby preventing hair loss and promoting hair growth.

Fermented Extract, Green Tea, Soybean, Camperol, Isoflavones, Stimulation, Hair Loss Prevention, Hair Growth

Description

Composition for improving condition of hair and scalp containing fermented plant extracts}

The present invention relates to a composition for improving the condition of hair and scalp containing fermented herbal extract, and more particularly to a composition for improving the condition of hair and scalp containing fermented extract of green tea or soybean in a gel type formulation using a thickener. will be.

In the modern society that emphasizes beauty, various studies are being actively conducted around the world to treat hair loss and promote hair growth of men or women who suffer from severe mental pain due to genetic or environmental hair loss.

There are about 100,000 hairs in the human body, and each hair repeats growth and degeneration through different cycles. The hair has a growing growth period (Anagen), a degenerative period (Catagen) that slows metabolism while maintaining the shape of the hair and the hair papilla is contracted and the hair follicles are contracted gradually so that the hair roots are pushed upwards and the hair follicles become smaller ( Telogen) is repeated in three phases, which can vary in terms of nutrition, medical history, heredity, constitution, hormone secretion or aging.

There are many reasons for hair loss. Androgenetic alopecia due to androgenic secretion and genetic influences; Alopecia areata due to autoimmune abnormalities due to stress; Restless hair loss after delivery due to hormones such as estrogen in late pregnancy; Hair loss due to malnutrition and metabolic disorders; Hair loss due to abnormal scalp environments such as skin diseases, keratin and dandruff; And hair loss by stimulation of the scalp through chemical treatment such as staining or perm.

Recently, as biotechnology is further developed, new cosmetic raw materials are being developed by separating pure microorganisms from various microorganisms using fermentation technology. However, depending on the microbial conditions, different types of substances were made, and there was a problem such as the smell of microorganisms. Recent research is using a method to separate the core pure enzymes that are responsible for the fermentation of microbial fermentation and develop them into new cosmetic ingredients. However, it has been known that there is an efficacy effect on hair loss prevention and hair growth in relation to hair and scalp, but the effect is still very weak.

In addition, conventional tonic formulations having an effect on hair loss prevention and hair growth may flow down to the scalp and cause eye irritation or irritation. However, recently released foam type formulations do not flow down, but have a sticky and damp feeling, which tends to reduce the fresh feeling of use on the scalp.

Therefore, there is an urgent need to develop compositions that are effective in improving ease of use and ease of use, relieving irritation to the scalp, and maintaining hair growth periods for a long time to prevent hair loss and promote hair growth.

Accordingly, the present inventors have provided an anti-hair loss and hair growth effect, and solved problems such as scalp side effects to develop a composition that can provide a stimulating effect when used in hair and scalp, gel type formulation using a thickener The fermented extract of green tea or soybean was found to alleviate the scalp irritation and to impart hair root strengthening, hair loss prevention and hair growth promoting effect and completed the present invention.

Accordingly, an object of the present invention is to improve the convenience of use, to relieve scalp irritation, to promote the induction from the resting phase to the growth hair cycle and to maintain the growth hair cycle for a long time to strengthen the hair roots and prevent hair loss and hair growth promoting effect And to provide a composition for improving the scalp condition.

In order to achieve the above object, the present invention is a hair and scalp composition containing an alcohol, a thickener; And it provides a composition for improving hair and scalp conditions containing at least one fermented extract selected from the group consisting of green tea and soybean as an active ingredient.

The thickening agent contained in the composition of the present invention is ammonium acryloyldimethyltaurate / VP copolymer (Ammonium acryloyldimethyltaurate / VP copolymer), the fermentation extract is in the group consisting of camphorol (kaempferol) and isoflavones (isoflavone) It is characterized in that at least one selected.

The composition according to the present invention improves the convenience of use as a gel-type formulation using a thickener, and contains the fermented extracts of green tea and soybeans, camphorol and isoflavone, as active ingredients to alleviate scalp irritation and in the resting phase. The hair cycle promotes induction and maintains the growing hair cycle for a long time, thus reducing the hair loss of the scalp and promoting hair growth.

The composition of the present invention contains a fermented extract of green tea or soybean as an active ingredient as a gel type using a thickener.

The ethanol thickener used in the present invention is an ammonium acryloyldimethyltaurate / VP copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers. It is in copolymer form. .

Ammoniumacryloyldimethyltaurate / VPicopolymer is used as a thickening agent as a synthetic polymer. This ingredient is added to skin care products such as after shave lotion, body lotion after shaving, and hand lotion. Most thickeners do not increase with high levels of ethanol in solubilized formulations such as tonics, while ammonium acryloyldimethyltaurate / VP copolymers have the advantage of increasing with high levels of ethanol. Have. In addition, by increasing the existing solubilized tonic formulation with ammonium acryloyl dimethyl taurate / V-copolymer to produce a gel formulation, the downflow that is a disadvantage of using the existing formulation is improved to increase the time the active ingredient stays on the scalp. Therefore, the absorption time of the active ingredient is increased to help prevent hair loss and promote hair growth.

In the present invention, it is preferable to contain ammonium acryloyl dimethyl taurate / V-Picopolymer in an amount of 0.001 to 5% by weight based on the total weight of the composition, for the purpose of improving the convenience of use and the feeling of use. When the content of the V-Picopolymer is less than 0.001% by weight, the efficacy and effect are insignificant, and when the content of the V-Picopolymer exceeds 5% by weight, problems in stabilizing the formulation and feeling of use occur.

Green tea (Thea sinensis Linnaeus) is an evergreen tree or shrub belonging to theaceae. Green tea is the second most widely consumed beverage after water, and its efficacy has long been studied. Green tea, black tea and oolong tea are produced from the leaves. The green tea is obtained by inactivating oxidation-related enzymes by vaporizing tea leaves, stems or flowers, and stably maintaining the polyphenol component. Polyphenols found in green tea are known as flavonols and catechins, and are known to have various effects such as antioxidant, anticancer, anti-inflammatory and antibacterial properties, and are widely used as cosmetic raw materials.

Green tea fermented extract used in the present invention is camphorol (kaempferol). It is characterized in that it is derived from green tea seed or green tea leaves, and it is possible to produce a large amount of camphorol which is a major bioactive substance from green tea seed and green tea leaves by the fermentation method.

Camphorol (kaempferol) used in the present invention is represented by the following formula (1), and is one of the representative components of flavonol (flavonol), one of flavonoids (flavonoid) is widely distributed in the flowers or leaves of plants.

In particular, camphorol is a substance with excellent physiological activities such as antioxidant and anti-inflammatory, and various effects have been researched and applied to various fields.

Camphorol, the green tea fermentation extract used in the present invention, may be prepared by a method known in the art, and preferably, may be prepared by the method described in Patent Publication 10-2006-0083778. Specifically, green tea seed or green tea leaves using about 1 to 6 times water or at least one organic solvent selected from the group containing ethanol, methanol, butanol, ether, ethyl acetate and chloroform or a mixture of these organic solvents with water To obtain green tea seed or green tea leaf extract. Then, the extracts obtained were genus Aspergillus, Bacillus, Penicillium, Rhizopus, Cryptococcus and Microbacterium. One or more microorganisms or glucosidase, arabinosidase, rhamnosidase, xylosidase, cellulase, hesperidina selected from the group consisting of the genus Hesperidinase, naringinase, glucuronidase, pectinase, galactosidase and amyloglucosidase selected from the group consisting of Hydrolysis with one or more enzymes yields camphorol.

Soybeans are Glycine soja ) is a variety grown as an edible crop. Fruits are edible, streaked, flat oval, with 1-7 seeds. When fully cooked, the pod bursts, dispersing the seeds. Seeds vary in size, including round, flat and round, depending on the variety. Seeds come in many varieties such as yellow, black, light brown, and green. Recently, research on soybeans has been actively conducted, and it is consumed not only as a grain but also as a drink. In addition, it is also used in cosmetics, it is known to have an effect on the dry skin moisturizing effect, soothing itching, hair loss prevention, but the effect is very weak.

Soybean fermented extract used in the present invention is isoflavon (isoflavon). Soy isoflavon is typically genistein, daidzein, and glycidin. These are antioxidants that remove the active ingredient. In addition, isoflavones have a structure similar to estrogen, a female hormone, and have a high absorption rate in the body, and have effects such as removing the sebum by suppressing testosterone.

Isoflavon used in the present invention is represented by the following formula (2).

Soybean extract used in the present invention is obtained from soybean seeds can be extracted by the following method. Soybean seeds are inoculated with a Bacillus culture solution and fermented to obtain isoflavones.

In the present invention, at least one fermented extract selected from the group consisting of camphorol and isoflavone, which are products of the respective fermentation and extraction methods of the green tea and soybean, for the purpose of improving the hair and scalp condition, 0.001 to the total weight of the composition, respectively. It is preferable to contain in 10 weight%. This is because when the content of the fermented extract is less than 0.001% by weight, the efficacy and effect are insignificant, and when it exceeds 10% by weight, there is a problem in stabilizing the formulation.

The composition for improving hair and scalp condition of the present invention not only improves scalp condition by reducing scalp itching and relieves scalp irritation by relieving inflammation of the scalp, but also affects hair growth by improving the condition of the scalp. In other words, it relieves scalp irritation and nourishs thinner hair, helping to grow hair into elastic and healthy hair. In addition, it promotes the induction from the resting phase to the growth phase hair cycle, and maintains the growth phase hair cycle for a long time provides the effect of reducing the hair loss phenomenon of the scalp and promoting hair growth.

The hair and scalp condition improving composition of the present invention is particularly effective in the gel-type formulation of the formulation containing alcohol, in particular the formulation of the hair and scalp improving composition of the present invention hair gel tonic, hair nourishing cosmetics It is limited to cosmetic compositions of gel type, such as a gel.

In addition, in the gel type formulation, other ingredients in addition to the above essential ingredients may be appropriately selected and blended by those skilled in the art without difficulty according to the kind or purpose of use of other external preparations.

In each of the above formulations, other ingredients other than camphorol and soy isoflavones of green tea may be appropriately selected and blended by those skilled in the art without difficulty according to the type or purpose of external preparation.

Hereinafter, although an Example and a test example are given and demonstrated more concretely of this invention, this invention is not limited only to these examples.

Preparation Example 1 Preparation of Camperol, a Fermentation Product of Green Tea

6 kg of hexane was added to 2 kg of green tea seeds, and extracted by stirring and stirring three times at room temperature. Then, 4 L of 80% methanol was added to 1 kg of degreased green tea seeds, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the filtrate was filtered, the residue and the filtrate were separated by centrifugation, and the extract obtained by concentrating the separated filtrate under reduced pressure was suspended in water, and then extracted five times with 1 L of ether to remove the pigment, and the aqueous layer was 1-. Extracted three times with 500 ml of butanol. The total 1-butanol layer thus obtained was concentrated under reduced pressure to obtain 1-butanol extract, which was dissolved in a small amount of methanol, and then added to a large amount of ethyl acetate to dry the resulting precipitate, thereby obtaining 250 g of green tea seed extract.

10 g of the obtained green tea seed extract was dissolved in 100 ml of 0.1 M acetic acid buffer solution (pH 4.5), and 2.5 g of enzyme (0.5 g of hesperidinase, 0.5 g of naringinase, 0.5 g of cellulase, beta-glucu) 0.2 g of ronidase, 0.5 g of beta-galactosidase, 0.3 g of amyloglucosidase; manufactured by Sigma) was periodically checked by thin layer chromatography with stirring at 37 ° C. for 48 hours, and the substrate After the complete disappearance, the mixture was heated for 10 minutes in hot water (80-100 ° C.) to terminate the reaction. The reaction solution was concentrated under reduced pressure to remove the solvent, 200 ml of ethanol was added to the residue, followed by stirring (3 times). Removal through, and the filtrate was concentrated under reduced pressure to give the product. The obtained product was separated by silica gel column chromatography (chloroform: methanol = 8: 1 to 4: 1) to obtain 1.02 g of camphorol (public patent 10-2006-0083778).

Preparation Example 2 Preparation of Isoflavones as a Soybean Fermentation Product

Purified water was added to the soybean seeds for sterilization and ripening, followed by inoculation with a Bacillus broth, followed by fermentation with stirring at 30 to 40 ° C. 100% ethanol was added to the soybean seed solution during fermentation, extracted 2-3 times with stirring, and then separated and concentrated. After concentration, the porous adsorptive resin was washed with water and 10% ethanol aqueous solution, and then concentrated under reduced pressure by adding 60% ethanol aqueous solution to prepare a solid. Soluble component was completely dissolved by adding about 20 times of water at 50 to 60 ° C., and the mixture was allowed to stand for 12 to 24 hours at a low temperature of 4 to 10 ° C. to recrystallize the isoflavone and centrifuged to obtain isoflavone. .

[Comparative Examples 1-3 and Examples 1-3]

The components of Comparative Examples 1 to 3 and Examples 1 to 3 were prepared by mixing at room temperature in the compositions shown in Table 1 below.

In Table 1, camphorol and isoflavones were prepared in Preparation Examples 1 and 2, respectively, and the green tea extract was used as the green tea seed extract before fermentation using an enzyme in the preparation example 1.

Ingredient (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 ethanol 50.0 50.0 50.0 50.0 50.0 50.0 Green tea extract 1.0 - - 1.0 - - Camphorol - 0.1 - - 0.1 - Isoflavones - - 0.1 - - 0.1 Ammonium Acryloyldimethyl Taurate / VPicopolymer - - - 1.5 1.5 1.5 Purified water balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100)

Test Example 1 Skin Irritation Relief Test

Test methods for skin irritation are as follows. In order to test the degree of skin irritation of the composition of the present invention, the composition of Comparative Examples 1 to 3 and Examples 1 to 3 Haye's Test Chamber for 10 women in their 20-30s The skin patch test (Patch Test) was performed to the upper arm using the. Those with psoriasis, eczema and other skin lesions, pregnant women, lactating or contraceptives, and antihistamines were excluded from this study.

After wiping the test site with 70% ethanol and drying, 15 g of the prepared test substance was dropped into a chamber, and then fixed on the upper part of the test site. The patch was applied for 24 hours, and after removing the patch, the test site was marked with a marking pen, and the test site was observed after 30 minutes, 24 hours, and 48 hours, respectively.

Determination was carried out 30 minutes, 24 hours and 48 hours after patch removal, skin reaction was determined according to the rules of the International Contact Dermatitis Research Group (ICDRG) of Table 2 below, the test results are shown in Table 3 below Indicated.

evaluation Average stimulus level
Mean Score Smile stimulation
Light stimulation
Moderate irritation
Strong stimulation
Non-irritating 0 to 0.9
1.0 to 2.9
3.0 to 3.9
4.0 to 4.9
5.0 to

time Skin irritation degree of test substance Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 30 minutes 1.6 1.3 1.2 0.4 0.5 0.4 24 hours 1.0 0.6 0.6 0 0 0 48 hours 0 0 0 0 0 0

As can be seen from the results in Table 3, Comparative Examples 1 to 3 exhibited a mean stimulation degree of 1.2 to 1.6 at 30 minutes of, and after 24 hours, the average stimulation degree exceeded 0.5, but Example 1 ~ 3 showed almost no stimulus with an average degree of stimulation of less than 0.5 at 30 minutes. In addition, after the application of Examples 1 to 3, the composition of the present invention 24 hours and 48 hours, all the subjects showed no stimulation. Through this, it can be seen that, unlike the tonic formulation, a gel-type formulation containing camphorol or an isoflavone component can alleviate skin irritation.

[Test Example 2] Test for preventing hair loss

Ten subjects with initial hair loss were tested for anti-hair loss for 12 weeks. After using the compositions of Comparative Examples 1 to 3 and Examples 1 to 3 once a day for 12 weeks, after 12 weeks elapsed after collecting the hair fall off hair was collected and counted, the results are shown in Figure 1 Indicated.

As can be seen in Figure 1, when treated with the composition of Examples 1 to 3 according to the present invention it was confirmed that the number of falling off hair significantly reduced. It was confirmed that there is an effect of preventing hair loss and more effective hair growth by promoting the transition to the growth hair cycle by acting on the resting hair cycle.

[Test Example 3] Evaluation of stimulation sensory evaluation in the scalp

Sensory evaluation of the degree of irritation, eye stinging and stiffness in the scalp was performed by the following method.

After shampooing using Comparative Examples 1 to 3 and Examples 1 to 3 above, dry the towel and apply it to both scalp on the basis of the crown. Sensory evaluation). Sensory evaluation items were selected to irritate the scalp, eyes stinging and swelling after use, freshness after use, and overall satisfaction after use, and the results are shown in Table 4 below.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Scalp irritation 4.3 3.9 3.8 3.0 2.9 3.2 Eye sting and stiffness after use 4.0 3.5 3.6 2.0 1.7 1.5 Freshness after use 3.6 4.0 3.8 5.2 5.5 5.4 Overall satisfaction after use 4.1 4.2 4.0 5.0 5.4 5.4

As shown in Table 4, when using the compositions of Examples 1 to 3 compared to Comparative Examples 1 to 3 was confirmed that the irritation and eye sting in the scalp is resolved and the overall satisfaction is also improved. In addition, the case of Example 2 containing the camphorol extracted by fermentation compared to Example 1 containing the general green tea extract is also low tingling and stiffness, excellent freshness after use of the composition, high overall satisfaction after use of the composition You can see it coming out.

Hereinafter, based on the results of the above test example, various formulation examples are shown and presented. However, these formulation examples are intended to illustrate the present invention, and it is apparent to those skilled in the art that the formulation of the present invention is not limited to these formulation examples.

[Formulation Example 1] Hair Gel Tonic

Hair gel tonic according to the present invention was prepared in the composition of Table 5 below.

ingredient Weight ratio (%) ethanol 50 menthol 0.05 Salicylic acid 0.05 Camphorol 0.1 Ammonium Acryloyldimethyl Taurate / VPicopolymer 1.5 Spices and Colors Proper amount Purified water Balance (to 100)

Formulation Example 2 Hair Nourishing Cosmetic Gel

Hair nourishing cosmetic gel according to the present invention was prepared in the composition of Table 6.

ingredient Weight ratio (%) ethanol 30.0 Polysorbate 60 1.5 glycerin 3.0 Xylitol 1.0 Camphorol 0.1 Ammonium Acryloyldimethyl Taurate / VPicopolymer 1.5 antiseptic Proper amount Spices and Colors Proper amount Purified water Balance (to 100)

1 is a graph showing the hair loss preventing effect of the compositions of Comparative Examples 1 to 3 and Examples 1 to 3 of the composition according to the present invention.

Claims (8)

In the composition for hair and scalp containing ethanol 30% by weight or more based on the total weight of the composition, 1) thickeners; And 2) kaempferol as an active ingredient; Containing, The thickener is ammonium acryloyldimethyltaurate / VP copolymer, The ammonium acryloyl dimethyl taurate / V copolymer is contained in an amount of 0.001 to 5% by weight based on the total weight of the composition, The camphorol is characterized in that it is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition, Cosmetic composition for improving the condition of hair and scalp of the gel type. delete delete delete delete According to claim 1, wherein the composition is a cosmetic composition for improving the hair and scalp condition, characterized in that to relieve scalp irritation. The cosmetic composition for improving the condition of hair and scalp according to claim 1, wherein the composition promotes hair growth or prevents hair loss. According to claim 1, wherein the composition is a hair gel tonic or hair nutrition cosmetic composition for improving the hair and scalp condition, characterized in that the gel formulation.

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