KR101558185B1 - Composition for improving condition of hair and scalp containing plant extracts - Google Patents

Abstract

The present invention relates to a composition for improving hair and scalp containing bamboo sap. More specifically, it contains bamboo sap, which is effective to alleviate irritation and irritation such as itching and stinging of the scalp which may appear in chemical treatments such as dyeing and perming, and is effective in preventing hair loss and promoting hair growth And a composition for improving scalp condition. In addition, the composition may further comprise one or more plant extracts selected from the group consisting of peony root extract, white porcelain extract, Sasa extract, and green tea extract.

Peony extract, white porcelain extract, Sasuo extract, green tea extract, relieve irritation, prevent hair loss, promote hair growth

Description

Technical Field [0001] The present invention relates to hair and scalp containing plant extracts containing bamboo sap,

The present invention relates to a composition for improving hair and scalp containing bamboo sap. More specifically, it contains bamboo sap, which is effective to alleviate irritation and irritation such as itching and stinging of the scalp which may appear in chemical treatments such as dyeing and perming, and is effective in preventing hair loss and promoting hair growth And a composition for improving scalp condition. In addition, the composition may further comprise one or more plant extracts selected from the group consisting of peony root extract, white porcelain extract, Sasa extract, and green tea extract.

In contemporary society, which emphasizes beauty, many people, both men and women, use hair dye, permanent hair, and the like in order to meet their individuality expression needs. However, in the case of some sensitive scalp, such dyeing, perming, and other chemical treatments may cause irritation and irritation such as itching or stinging of the scalp. These stimuli and inflammation are leading to environmental hair loss, and various studies are actively carried out to prevent hair loss of men or women suffering from serious mental suffering and to promote hair growth.

Therefore, it is urgent to develop a composition having an effect of alleviating scalp irritation and inflammation due to the use of various hair dyes, permanent agents and the like and preventing hair loss and promoting hair growth.

On the other hand, Korean Patent No. 0839648 discloses a composition having hair loss preventive and hair growth effect, which contains acaran sulfate and bamboo sap, Korean Patent No. 0755983 discloses a method of heating bamboo at 180 to 400 ° C for 24 to 48 hours And then cooling the collected bamboo extract to obtain a bamboo extract. The composition for promoting hair growth or preventing hair loss is known as an effective ingredient. Japanese Patent Laid-Open Publication No. 2008-120742 discloses a hair restorer containing bamboo ingredient extract obtained by immersing bamboo in ethanol. Japanese Patent Laid-Open Publication No. 2007-031340 discloses hair growth and hair growth A composition for promoting is known.

The present inventors have solved the above problems such as side effects in the scalp and studied a composition capable of providing a stimulation-relieving effect when used on hair and scalp and also capable of providing hair loss prevention and hair growth. As a result, In the case of containing more than one kind selected from the group consisting of peony root extracts extracted from roots of peony root, extracts of white porcine marijuana extracted from seeds of Sasa spp., Extracts of Sasa roots extracted from Sasa roots, and green tea extracts extracted from green tea, It is possible to alleviate the irritation and inflammation of the scalp which can appear in the same chemical treatment, as well as to prevent hair loss and promote hair growth, thereby imparting a force to the thinned hair, thus completing the present invention.

Accordingly, a problem to be solved by the present invention is to provide a composition capable of improving hair and scalp condition.

In order to achieve the above object, the composition for improving hair and scalp according to the present invention contains bamboo sap as an active ingredient. In addition, the composition may further comprise one or more plant extracts selected from the group consisting of peony root extract, white porcelain extract, Sasa extract, and green tea extract.

The composition for improving hair and scalp condition according to the present invention may be present in chemical treatment such as dyeing and perming by containing at least one kind selected from the group consisting of peony extract, white porcelain extract, dashi extract and green tea extract as active ingredients in bamboo sap. It has the effect of relieving irritation such as itching and stinging of the scalp and inflammation. It prevents the hair from being tapered due to the damage of the hair and scalp caused by the chemical treatment, and furthermore, Effect.

Bamboo sap is produced as a by-product during periodic cutting to help growth during bamboo cultivation. The composition ratio varies depending on the environmental factors such as the area normally cultivated, the species of bamboo, and the sampling period. However, protein (0.08 ), Calcium (422 mg / l), sugar (1.6 ~ 2.7 g / l) and amino acids (7.6 ~ 30 mg / l) and the pH is about 4.5.

Although the bamboo sap can be obtained from all bamboo trees, it is preferable from the standpoint of yield in terms of harvesting from the bamboo shoots, cotton bolls, and bamboo shoots, which are relatively useful weeds. As is commonly known, the bamboo roots are cut at the first node or just above the node of the second node (height: 10-20 cm), attached with a container, and then filtered with a filter cloth. The filtrate is generally sterilized and used in a cosmetic composition. It may be used as it is or may be used in powder form. Bamboo sap is preferably collected around May to June.

In the present invention, this bamboo sap solution can be used directly as an active ingredient of a composition for improving hair and scalp condition, or can be pretreated to prevent discoloration and spoilage before storage and used as an active ingredient.

On the other hand, in the pretreatment method, bamboo sap immediately after harvesting is filtered with a filtration membrane having a pore size of 0.001 to 0.45 μm, preferably 0.2 μm, and anhydrous ethanol is added to the filtrate in an amount of 7.0 wt% By weight, preferably 7.0 to 50% by weight. If the size of the filtration membrane is less than 0.001 탆, the filtration takes a long time. If the size exceeds 0.45 탆, the filtration efficiency is ineffective.

That is, by filtering with a filtration membrane, protein having a large molecular weight which is likely to precipitate or denature during long-term preservation of bacteria, microorganisms and microorganisms present in bamboo sap is removed, and then anhydrous ethanol is added to inhibit the activity of the enzyme Prevent discoloration and detachment.

 The pre-treated bamboo sap is sealed immediately under a nitrogen atmosphere to prevent intrusion of external bacteria or microorganisms.

The bamboo sap pretreated by the method described above has no skin irritation, has a stimulation-alleviating effect when used for hair and scalp, and can provide a hair loss prevention and hair growth effect.

The content of the hair and scalp care composition of the bamboo sap may be appropriately selected according to the formulation, and may be selected within the range of 0.01 to 99.5% by weight, preferably 1.0 to 90.0% by weight based on the total weight of the composition.

On the other hand, the present invention also relates to a composition containing at least one selected from the group consisting of peony root extracts extracted from roots of Peony root, white porcelain extracts obtained from seeds of Panax ginseng, and green tea extracts extracted from Sasa roots, green tea leaves, .

Hereinafter, the present invention will be described in more detail.

Peonies are peonies and Paeonia belonging to Paeoniaceae As a Lactiflora variety, its cultivation history is older than Moran. In one room, after washing the roots, the dried roots are called peony roots, and the roots of peony roots are called peony roots. The efficacy and efficacy of peonies have been studied for a long time, and the roots of peonies have been used as medicines for analgesic, abdominal pain, hematemesis, anemia and bruises. In addition, it is known that it has various effects and effects such as skin whitening and antioxidant as a cosmetic raw material. In the scalp and hair, it protects the hair from external damages, provides moisturizing to the scalp, induces hair growth, It is known that it has efficacy and efficacy to inhibit, but its efficacy and efficacy are very weak.

The peony root extract used in the present invention is an extract obtained by supercritical extraction of Peony root and can be extracted by the following method. To be diluted with peony and spray the CO ₂ supercritical extraction solvent, and still bound butylene glycol extract with a (Butylene Glycol) and then butylene glycol (Butylene Glycol) aqueous solution of 15% of the peony (Paeonia Lactiflora) belonging to the (Paeoniaceae) Peony extract is obtained.

Thujae semen is a seed of the Thuja orientalis (occidentalis) dwarf and Curpressaceae , long oval or long columnar in oval shape, 3 to 5 mm in length and 2 to 3 mm in diameter. The outer surface is pale yellow to yellowish white, and the old ones gradually change to yellowish brown and contain a lot of fatty oil. The outer surface of the seed is often wrapped in a thin film-like endothelium. The tip is usually pointed, with a point of dark brown with a horny rhomboid shape, and a dull circular shape with a thin color. Microscopic examination of the cross section of white porcelain reveals white to yellowish white, rich in endosperm, and rich in lipids (Korean Pharmacopoeia and herbal medicine specifications). The white porcelain has the efficacy of conscientious anxiety, Yoon Jang-taeun (introduction of oriental medicine), and Dongbok-Bok's hair piece is composed of rich, It is said that it should come out again with missing mustache or hair. In addition, white porcine can be used as a useful substance for hair loss symptoms, as it has 5? -Reductase inhibitory activity that enhances hair growth activity (Journal of Dermatological Science (2003) 31, 91-98).

The white porphyrin extract used in the present invention is an extract extracted from the seeds of a Japanese cabbage tree, and can be extracted by the following method. The white porcelain is extracted with twice the volume of 95% ethanol, filtered and concentrated, and then 5 times of water and 5 times of ethyl acetate are added to shake and the layer is separated. The water content of the ethyl acetate layer was removed using magnesium sulfate, filtered and concentrated to obtain a white porcelain extract.

Polygonum multiflorum is a vineous perennial plant belonging to Polygonaceae. Chrysophanol, Emodin, lecithin, etc., which are oxymethyl anthraquinone derivatives, have. Some records say that there are deficits and white porcelain in the records of some ancient books, and they are called enemy Suseo and Baekseoso. Sasao effectively absorbs ultraviolet rays and is effective as an antioxidant for scalp and hair. It is effective in preventing skin and scalp aging through antioxidant and astringent action.

The Sucrose extract used in the present invention is an extract obtained from Sasa roots and can be extracted by the following method. The roots of Sasa roots are extracted with 50% ethanol, filtered, and then treated with activated charcoal to remove the color and odor of the extract and filtered through a filter paper to obtain a Sasa extract.

Green tea (Thea sinensis Linnaeus) is an evergreen tree or shrub belonging to the tea tree (Theaceae). Green tea is the next most widely consumed beverage, and its efficacy has long been studied. Green tea, black tea and oolong tea are produced from the leaves. The green tea is obtained by inactivating the oxidation-related enzymes by steaming tea leaves, stems and flowers, and keeping the polyphenol component stably. The polyphenol component found in green tea is known as flavonol and catechin, and has been known to have various effects such as antioxidant, anticancer, antiinflammation, and antibacterial, and is widely used as a cosmetic raw material.

The green tea extract used in the present invention is an extract obtained from green tea leaves, stems and flowers, and can be extracted by the following method. The green tea is soaked in 30% ethanol at 25 ° C for 4 days, and then filtered using a filter paper to obtain a green tea extract.

The composition for improving hair and scalp according to the present invention contains two or more kinds selected from the group consisting of peony extract, white porcelain extract, dashi extract and green tea extract as an active ingredient to alleviate the irritation and inflammation of the scalp, And it has an effect on hair growth.

In addition, the content of each of the above peony extract, white porcelain extract, Sasa extract, and green tea extract is preferably 0.005 to 5% by weight based on the total weight of the composition. If the content of the active ingredient is less than 0.005% by weight, the effect is insignificant. If the content is more than 5% by weight, there is a problem in formulation stability.

The composition for improving hair and scalp state of the present invention is not particularly limited in the formulation, but may be a cosmetic having formulations such as hair tonic, hair nutritional lotion, scarf treatment, hair treatment, hair rinse, hair shampoo, Composition.

In addition, in the respective formulations, the ingredients other than the above-mentioned essential ingredients can be suitably selected and blended by those skilled in the art depending on the kind of the external preparation, the purpose of use, and the like.

Hereinafter, the present invention will be described in more detail with reference to examples and test examples, but the present invention is not limited to these examples.

[Referential Example 1] Preparation of bamboo sap

The first or second nodal area was cut out from the root of bamboo, and the bamboo sap from the roots was collected using a connector attached to the cut-off area. The bamboo sap just after harvesting was passed through a filtration membrane having a pore size of 0.2 mu m, and then anhydrous ethanol was added to the filtrate at a concentration of 7.0 wt% to perform pre-treatment. 100 g of the thus-obtained bamboo sap solution was pulverized according to a conventional vacuum concentration method to obtain 1.05 g.

[Reference Example 2] Preparation of peony extract

100 g of peanut roots were placed in a supercritical extraction tank, and 100 g of carbon dioxide and butylene glycol were added thereto. The supernatant was extracted at 40 ° C and 300 atm. Then, carbon dioxide was removed by reducing the pressure to obtain peony root extract. 45 g of butylene glycol and 225 g of water were added and mixed to obtain 300 g of supercritical fungus extract.

[Reference Example 3] Preparation of white porphyrin extract

1.5 kg of white porcelain was put into an extractor and 3 kg of 95% ethanol was added. Heat extraction was performed at reflux temperature for 6 hours. After cooling at room temperature, the mixture was filtered under reduced pressure through a filter paper. The filtrate was concentrated under reduced pressure to remove ethanol, and water and ethyl acetate were added to the concentrate in an amount of 5 times the amount of the concentrate. After stirring, the layers were separated and the water layer was discarded. The ethyl acetate layer was concentrated and reduced to obtain about 120 g of the extract.

[Reference Example 4] Preparation of Sasa extract

Ultrapure water was removed by using purified water, and debris was removed with ultrapure water using 250 mesh. After drying the roots at 50 ° C. for 24 hours, 50 kg of the dried roots of Sasa root were mixed with 250 kg of 50% ethanol (EtOH) and heated at 60 ° C. for 3 to 5 hours to extract. The foreign matter was removed by using 250 mesh and centrifugal separation and filtered with filter paper of 0.5 mu m. The color and odor of the extract were removed by treating the activated carbon. After filtration through filter paper of 3 mu m, 1 mu m, and 0.5 mu m over the third order, a butylene glycol solvent was added to obtain a sulfo extract.

[Reference Example 5] Preparation of green tea extract

Ultrapure water was removed by using purified water, and debris was removed with ultrapure water using 250 mesh. And extracted with 30% ethanol for 4 days at 25 ° C. The foreign matter was removed by using 250 mesh and centrifugal separation and filtered with filter paper of 0.5 mu m. After filtration through filter paper of 3 mu m, 1 mu m, 0.5 mu m over the third order, a butylene glycol solvent was added to obtain a green tea extract.

[Comparative Example 1 and Examples 1 to 4]

The compositions of Comparative Example 1 and Examples 1 to 4 were prepared with the compositions shown in Table 1 below.

Component (% by weight) Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Reference Example 1 10.0 10.0 10.0 10.0 10.0 Reference Example 2 - 1.0 - - - Reference Example 3 - - 1.0 - - Reference Example 4 - - - 1.0 - Reference Example 5 - - - - 1.0 ethanol 50 50 50 - - Purified water balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100)

[Test Example 1] Stimulation relaxation efficacy test

To evaluate the efficacy of the stimulant mitigation treatment by stimulation of the hair dye, the MEST method using a mouse was applied and the test method was as follows.

Six - week - old BALB / c mice were purchased and the test system was constructed with 10 - day quarantine and adaptation period. The test group was constructed as follows.

The hair was removed from the abdomen of the rats and 2.5% para-phenylenediamine (PPD) was applied for 3-5 days. After a one-week rest period, the hair dye was applied to the rat's ear and wiped off after 30 minutes. After a resting period of one week, the compositions of Examples 1 to 4 and Comparative Example 1 were applied twice at intervals of one hour. After applying the hair dye again, the compositions of Examples 1 to 4 and Comparative Example 1 were applied twice after 24 hours. After 24 hours, the weight of the ear was measured, and the weight of the ear that was pathologically organized by H & E staining was measured. The formulation of the hair dye is shown in Table 2 below and the measurement results are shown in Table 3 below.

ingredient Content (% by weight) 1 Component Purified water To 100 Sodium sulfite 0.5 Ascorbic acid 0.5 Polyoxyethylene < / RTI > 4.0 Polyoxyethylene oleyl ether 4.0 Cetostearyl alcohol 8.0 p-phenylenediamine 0.5 Resorcinol 0.5 Monoethanolamine Suitable amount ammonia Suitable amount 2 ingredients Purified water 0.1 Hydrogen peroxide (30%) 17.0 Phosphoric acid 0.1

Treated group Ear Weight (mg) Ear thickness (㎛) Comparative Example 1 15.92 + 0.225 457.13 + - 13.462 Example 1 9.74 0.984 258.20 ± 25.572 Example 2 9.38 ± 0.758 261.37 ± 25.337 Example 3 9.25 + - 0.483 266.56 ± 18.102 Example 4 9.54 + 0.249 253.72 + - 21.485

As can be seen from Table 3, it was confirmed that the ear weight and ear thickness decreased significantly when the composition of the present invention was pretreated with the compositions of Examples 1 to 4. Thus, the composition for improving hair and scalp according to the present invention has an effect of alleviating inflammation caused by a hair dye.

[Test Example 2] In vivo itching inhibition test

The itching inhibiting effect of the composition according to the present invention was tested. In order to facilitate skin application of the compositions prepared in Examples 1 to 4 and Comparative Example 1, hairless mice were used. All mice were 7 - week - old males and 8 - reared mice were used in all groups for comparison with negative controls.

The treatment with the external preparation was carried out in such a manner that 150 占 퐇 of the compositions of Examples 1 to 4 and Comparative Example 1 were spread and spread widely on the back region of the hairless mice. Morning and afternoon, twice a day for 1 day, and 2 days for the last treatment 30 minutes before the injection of the itch inducer.

The itching test gave a 30-minute adaptation time to the obsessive-to-obese mice, 30 minutes before the injection of the itch inducer. At the end of the adaptation period, compound 48/80 (compound 48/80), which is an itch inducing substance, was dissolved in physiological saline at a concentration of 1 mg / ml, and then intradermal injection was performed on the back skin of the adaptation test hamster . Immediately after the injection, the rats were placed in the observer for 30 minutes, and the number of scratches on the area where the itch inducing substance was injected into the hind legs was measured and displayed as a number. Except for scratching with the paws and biting with the mouth, only the scratching of the injection site with the hindpaw was regarded as an index of the itching behavior. The measurement results are shown in Fig. 1 and Table 4 below.

Treated group Itching substance Average number of scratches for 30 minutes Negative control group Saline solution 15.2 ± 35.2 Comparative Example 1 C48 / 80 151.2 ± 25.2 Example 1 C48 / 80 113.2 ± 27.0 Example 2 C48 / 80 115.3 ± 29.2 Example 3 C48 / 80 118.6 ± 22.8 Example 4 C48 / 80 119.2 ± 21.6

As can be seen from FIG. 1 and Table 4, the pretreatment group of the compositions of Examples 1 to 4 according to the present invention showed a tendency to suppress itching.

[Test Example 3] Test for preventing hair loss

The hair growth inhibitory effect of the present invention was confirmed using a mouse, and the effect of preventing hair loss was clinically tested in order to confirm whether it is effective in preventing hair loss of scalp hair. As a test method, only patients satisfying the following criteria were registered as study subjects.

1) A man who has good physical and mental health status of 20 years or older and who has hair loss

2) patients who maintain the same hair shape during the study period

3) Patients not to be stained during the study

4) Patients who do not have special hair supplies or hair care and manipulation during the study period

20 voluntary subjects who met the above conditions were selected and tested, and the results were recorded and evaluated on the evaluation sheet while grasping the specific patient individual status.

The hair loss prevention effect evaluation method measures the number of hairs that fall when the hair is wound. The shampoo used before and after the shampoo used in Comparative Example 1 and Examples 1 to 4 were compared. The number of hairs that fall when the hair is wrapped is recorded once a day, and the hair loss quantity is averaged on a monthly basis.

division Average number of hair loss after shampooing Comparative Example 1 Example 1 Example 2 Example 3 Example 4 After 1 month of use 17.78 13.20 13.28 12.73 13.11 After 2 months of use 14.22 10.42 9.82 11.24 11.32 After 3 months use 12.74 7.38 7.34 6.76 6.64

Thus, it was found that the amount of hair loss was remarkably decreased with the number of months after using the shampoo corresponding to Examples 1 to 4. From the above-mentioned test results, it was confirmed that the present invention provides a composition which is safe to the living body and which provides hair loss prevention and hair growth effect by using bamboo roots and herbal medicine extract together.

[Test Example 4] Hair growth effect test

The hair growth effect of the composition according to the present invention was tested.

Seven weeks-old mice (C57BL / 6) were sacrificed and the skin of the back area was cleaned. Eight mice were selected for each material group, and the compositions of Examples 1 to 4 and Comparative Example 1 were administered to each mouse group 150 占 퐇 / individual was applied for 21 days. As the negative control, 0.5% by weight of Peony root extract was dissolved in a solvent composed of water / ethanol / 1,3-butylene glycol (5/3/2) and used.

The weight of newly emerged hair after 23 days was measured and compared with the negative control, and the results are shown in Table 6 below.

Treated group Hair Weight (mg) Negative control group 26 ± 17 Comparative Example 1 60 ± 12 Example 1 73 ± 15 Example 2 71 ± 9 Example 3 72 ± 15 Example 4 78 ± 13

As can be seen from Table 5, in Examples 1 to 4 according to the present invention, it was confirmed that the hair growth promoting effect was promoted by acting on the mouse of the resting hair cycle and promoting the transition to the growing hair cycle.

Based on the results of the above-described test examples, various formulation examples are prepared and presented. However, it should be apparent to those skilled in the art that these formulation examples are for illustrating the present invention and that the formulation of the present invention is not limited to these formulation examples.

[Formulation Example 1] Hair tonic

ingredient Weight ratio (%) ethanol 50 menthol 0.02 glycerin 3 Salicylic acid 0.05 Bamboo sap 10.0 White potato extract 0.5 Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 2] Hair lotion

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 EDTA 2Na 0.2 Hydroxyethyl cellulose 0.5 Mineral oil 5.0 Bamboo sap 10.0 Sashou extract 1.0 Green tea extract 0.5 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 3] Hair nutrition lotion

ingredient Weight ratio (%) Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Mineral oil 10.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Bamboo sap 20.0 Peony extract 1.0 Green tea extract 0.5 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 4] Hair shampoo

ingredient weight% Purified water Balance (To 100) Bamboo sap 30.0 Green tea extract 0.5 Sodillauryl sulphite 36.0 Cocamidopropyl betaine 8.0 Palmitidine dimalate 2.0 Glycollosteralate 1.5 Polyquaternium 10 0.5 Saitric Acid 0.1 glycerin 2.0 Preservatives, coloring and flavoring Suitable amount

[Formulation Example 5] Hair rinse and treatment

ingredient weight% Purified water Balance (To 100) Bamboo sap 5.0 White potato extract 0.5 Sashou extract 1.0 Green tea extract 0.5 Propylene glycol 2.0 Cetyltrimethylammonium chloride 1.0 Cetyl alcohol 3.0 Stearyl alcohol 3.0 Mineral oil 0.5 Saitric Acid 0.2 Polydimethylsiloxane 1.0 Preservatives, coloring and flavoring Suitable amount

Claims (6)

a) bamboo sap; And b) at least one selected from the group consisting of Paeonia Lactiflora extract, Thujae semen extract, Polygonum multiflorum , and Green tea extract ( Thea sinensis Linnaeus ); As an active ingredient, Wherein the content of each of the Peony root extract, White Pepper extract, Sasa extract, and Green tea extract is 1.0 wt% based on the total weight of the composition. delete delete delete delete The composition according to claim 1, wherein the composition is selected from the group consisting of hair tonic, hair nourishing lotion, scarf treatment, hair treatment, hair rinse, hair shampoo and hair lotion.