KR20180100288A - Composition for prevention of losing hair or promotion of growing hair - Google Patents
Composition for prevention of losing hair or promotion of growing hair Download PDFInfo
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- KR20180100288A KR20180100288A KR1020180102773A KR20180102773A KR20180100288A KR 20180100288 A KR20180100288 A KR 20180100288A KR 1020180102773 A KR1020180102773 A KR 1020180102773A KR 20180102773 A KR20180102773 A KR 20180102773A KR 20180100288 A KR20180100288 A KR 20180100288A
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- extract
- composition
- hair
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- soybean
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Abstract
Description
본 발명은 탈모 방지 또는 육모 촉진용 조성물에 관한 것이다.The present invention relates to a composition for preventing hair loss or promoting hair growth.
대부분의 동물들은 계절에 따라 털이 한꺼번에 빠지고 새로 털이 나는 털갈이를 하나, 사람은 전체 약 10만개 정도의 모발 중 매일 100개 정도가 빠지고, 또한 매일 약 100개 정도가 새로 태어나면서 항상 비슷한 개수를 유지한다.Most animals fall into hairs all at once and new hairy molasses, with about 100 of them hairs per day of about 100,000 hairs in total, and about 100 hairs per day are kept fresh each year .
모발의 주기(hair cycle)는 성장기, 퇴행기, 휴지기의 3주기로 크게 나눌 수 있다. 그 중 성장기(anagen)는 모유두에서 활발한 세포 분열이 일어나 새로운 모발의 성장이 촉진되는 시기로, 이 시기에만 모발이 성장한다. 각 모발은 대략 남성은 3~5년, 여성은 4~6년 정도의 성장기를 가지므로 전체적으로 볼 때 약 80~85%의 모발이 성장기에 해당한다. 퇴행기(catagen)는 세포 분열이 점차 멈추어 가는 시기로 대략 3~4주 정도이다. 마지막으로 휴지기(talogen)는 모유두가 위축되어 모발이 모세혈관과 분리되어 단순히 두피에 박혀 있는 시기이다. 대략 3개월 정도이며 휴지기에 있는 모발은 대개 물리적 자극에 의해 쉽게 빠진다.The hair cycle can be roughly classified into three periods: growth period, regressor period, and rest period. Among them, anagen is a period when active division of cells occurs in the dermal papilla and the growth of new hair is promoted. During this period, the hair grows. Each hair has a growth period of approximately 3 to 5 years for males and 4 to 6 years for females, and as a whole, approximately 80 to 85% of hair corresponds to growth. The catagen is about 3 to 4 weeks when cell division is gradually stopped. Finally, the taloge is a period when the hair is separated from the capillaries and is simply put on the scalp. Approximately three months, and the hair in the rest period is usually easily removed by physical stimuli.
본 발명은 탈모 방지 또는 육모 촉진용 및 모발 건강 증진용 조성물을 제공하고자 한다.The present invention provides a composition for preventing hair loss or for promoting hair growth and for improving hair health.
본 발명의 일측면은 콩 추출물; 및 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 유효 성분으로 포함하는 탈모 방지 또는 육모 촉진용 조성물을 제공한다.An aspect of the present invention relates to a soybean extract; And a composition for promoting hair loss prevention or hair growth, which comprises as an active ingredient at least one extract selected from the group consisting of flax seed extract, flaxseed extract and licorice extract.
본 발명의 다른 일측면은 콩 추출물; 및 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 유효 성분으로 포함하는 모발 건강 증진용 조성물을 제공한다.Another aspect of the present invention relates to a soybean extract; And at least one extract selected from the group consisting of prolapsed extract, flaxseed extract and licorice extract, as an active ingredient.
본 발명의 또 다른 일측면은 상기 조성물을 포함하는 화장품, 식품 또는 약학 조성물을 제공한다.Another aspect of the present invention provides a cosmetic, food or pharmaceutical composition comprising the composition.
본 발명에 따른 조성물은 콩 추출물; 및 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 유효 성분으로 포함함으로써, 각 성분의 시너지 작용을 통해 모세 혈관의 혈액 순환을 개선하며 혈액의 항산화능을 증가시키고 혈중 지질을 감소시켜 혈액을 맑게 하여 모근의 상피 세포에 영양을 효율적으로 공급한다. 또한 모근을 자극하여 모유두 세포의 활성화를 유도함에 있어 매우 우수한 효과를 나타낸다. 그리고 각 모발에 있어, 휴지기에서 성장기로의 이행을 촉진함으로써 육모를 촉진하는 효과가 높다. 따라서 탈모의 진행을 억제함과 동시에 육모를 촉진하고, 나아가 모발과 두피의 노화를 방지하고 모발 건강을 증진시키는 효과가 매우 뛰어나다.The composition according to the present invention comprises soybean extract; And extracts of at least one member selected from the group consisting of flax seed extract, flaxseed extract and licorice extract as an active ingredient, thereby improving the blood circulation of the capillary blood vessels through the synergistic action of each component, increasing the antioxidative capacity of blood and decreasing blood lipid To clear the blood and provide nutrition efficiently to the epidermal cells of the hair follicle. It also has a very good effect in inducing activation of the hair follicle cell by stimulating the hair follicle. In each hair, the effect of accelerating the hair growth is promoted by promoting the transition from the resting period to the growing period. Therefore, it suppresses the progress of hair loss, promotes hair growth, prevents aging of hair and scalp, and enhances hair health.
도 1은 본 발명에 따른 조성물 적용에 따른 마우스의 모발 성장 정도를 보여주는 사진이다.1 is a photograph showing the degree of hair growth in a mouse according to the composition of the present invention.
본 명세서에서 “탈모”는 두피로부터 모발이 탈락하는 현상 또는 모발이 성기거나 가늘어지는 상태를 의미하며, “탈모 방지”라 함은 상술한 바와 같은 탈모를 예방하고 억제하는 것을 의미하고, “육모 촉진”이라 함은 새로운 모발의 생성 촉진뿐만 아니라 기존 모발이 건강하게 자라도록 하는 것을 의미한다.As used herein, the term " hair loss " means prevention of hair loss and prevention of hair loss as described above, and " hair growth promotion "Refers to promoting the creation of new hair as well as allowing existing hair to grow healthily.
모발의 성장은 온도 또는 일광과 같은 환경적인 요인, 개체의 영양 상태와 질환 유무, 호르몬, 분만 여부, 방사선 또는 각종 약물에의 노출 여부 등 여러 가지 요인에 영향을 받는다. 탈모의 주 요인은 크게 생리적인 측면의 신체 내적인 요인과 외부 환경에 의한 외적인 요인으로 나눌 수 있다. 생리적인 측면의 신체 내적인 요인으로는 남성호르몬(androgen)의 일종으로 알려져 있는 테스토스테론(testosterone)과 테스토스테론을 DHT(dihydrotestosterone)로 변환 시켜 피지의 분비를 증가시키는 5-알파 환원효소(5-alpha reductase)의 활성 증가를 예로 들 수 있다. 외부 환경에 의한 외적인 요인으로는 혈액 순환이 원활하게 이루어지지 않아 발생하는 혈관 위축에 따른 모근에로의 영양 공급 부족, 두피 건조 등을 들 수 있다. 이를 토대로 탈모를 방지하고 육모를 촉진하기 위해서, 혈관을 확장시켜 모근에 영양 공급이 잘 이루어지도록 하거나, 모발의 구성 성분과 동일한 작용을 하는 성분을 직접 모근에 공급하거나, 세정제 또는 피지 분비 억제제를 이용하여 모근 부위의 과잉 피지를 제거하거나, 보습제를 이용하여 두피의 건조를 막는 방법 등이 이용될 수 있다.Hair growth is influenced by various factors such as temperature or sunlight, the nutritional status of the individual, the presence or absence of the disease, the presence of hormones, delivery, and exposure to radiation or various drugs. The main factors of hair loss are physiological internal factors and external factors. Physiological aspects of the body include testosterone, a type of male hormone (androgen), and 5-alpha reductase, which converts testosterone into DHT (dihydrotestosterone) to increase secretion of sebum For example). Outside factors due to the external environment include lack of nutritional supply to the hair follicles due to vascular atrophy caused by a lack of blood circulation, and scalp drying. On the basis of this, in order to prevent hair loss and promote hair growth, it is necessary to expand the blood vessels so that the nutrients are supplied to the hair follicles, or to supply directly the hair follicles with the components having the same action as the hair components, or by using a detergent or an anti- To remove excess sebum in the hair follicles, or to prevent drying of the scalp using a moisturizing agent.
본 발명의 일측면은 콩 추출물; 및 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 유효 성분으로 포함하는 모발용 조성물, 구체적으로 탈모 방지 또는 육모 촉진용 및 모발 건강 증진용 조성물을 제공한다. An aspect of the present invention relates to a soybean extract; And a composition for hair, which comprises at least one extract selected from the group consisting of an extract of Panax ginseng, a flaxseed extract and a licorice extract, as an active ingredient, more specifically, a composition for promoting hair loss prevention or hair growth and for promoting hair health.
본 발명의 일측면에서, 콩 추출물은 천연물 추출 방법에서 일반적으로 추출 용매로 사용되는 고농도의 유기 용매 대신 저농도의 유기 용매를 사용하여 추출한 추출물일 수 있다. 저농도의 유기 용매에 의한 추출물은 기존의 추출물에 비해 모유두 세포의 활성화를 유도하여 증식을 촉진하는 효과 및 모세 혈관을 확장시켜 혈액 순환을 활성화하여 모근에 영양을 공급하는 효과가 뛰어나므로, 탈모 방지, 육모 촉진 및 모발 건강을 증진하는 효과가 우수하다. In one aspect of the present invention, the soybean extract may be an extract obtained by using a low concentration organic solvent instead of a high concentration organic solvent generally used as an extraction solvent in a natural material extraction method. The extract of the low concentration organic solvent is more effective than the conventional extract to induce activation of the dermal papilla cell to promote proliferation and to expand the capillary blood vessels to activate the blood circulation to supply nutrition to the hair follicle, It is excellent in promoting hair growth and promoting hair health.
본 발명의 일측면에서, 상기 유기 용매는 저급 알코올, 구체적으로 C1~C5 알코올을 포함한다. 상기 C1~C5 알코올은, 예를 들어, 메탄올, 에탄올, 이소프로필알코올, n-프로필알코올, n-부탄올 및 이소부탄올로 구성된 군으로부터 선택된 어느 하나 또는 둘 이상의 혼합 용매일 수 있으며, 구체적으로 에탄올일 수 있으나, 이에 제한되는 것은 아니다. 본 발명의 또 다른 일측면에서, 상기 유기 용매의 농도는 1 내지 70%(v/v), 구체적으로 1 내지 40%(v/v), 더 구체적으로는 5 내지 30%(v/v), 보다 더 구체적으로는 12 내지 25%(v/v)일 수 있다.In one aspect of the present invention, the organic solvent comprises a lower alcohol, specifically a C 1 to C 5 alcohol. The C 1 to C 5 alcohols may be any one or a mixture of two or more selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol, Ethanol, but is not limited thereto. In another aspect of the present invention, the concentration of the organic solvent is 1 to 70% (v / v), specifically 1 to 40% (v / v), more specifically 5 to 30% (v / , And more specifically 12 to 25% (v / v).
본 발명의 일측면에서, 콩은 그 추출물이 탈모 방지, 육모 촉진 또는 모발 건강 증진 효과를 가지는 콩을 모두 포함한다. 본 발명의 다른 일측면에서, 콩은 검은콩 또는 유색콩을 포함한다. 본 발명의 또 다른 일측면에서, 콩은 서리태, 서목태, 흑태, 황태, 푸르대콩(청태), 강낭콩, 얼룩강낭콩, 울타리콩, 녹두, 적두, 거두, 콩나물콩, 선비콩 및 대두로 구성된 군으로부터 선택된 하나 이상을 포함한다.In one aspect of the present invention, the soybean contains all of the soybean extracts having the effect of preventing hair loss, accelerating hair growth, or improving hair health. In another aspect of the invention, the beans comprise black beans or colored beans. In another aspect of the present invention, the soybean is selected from the group consisting of Seolite, Seomyeutae, Blackcurrant, Chrysanthemum, Fuda bean, Kidney bean, Stark bean, Fence bean, Mung bean, Red bean, And includes at least one selected.
본 명세서에서 “검은콩(black bean)”이란, 낟알 껍질의 색이 검은 빛깔을 띠는 콩을 총칭한다. 상기 검은콩의 예로는, 서리태, 서목태 및 흑태 등을 들 수 있으나, 이에 제한되는 것은 아니다. 검은콩의 명칭은 지역이나 분류, 방언의 영향 등에 의해 다양하게 불릴 수 있다. 본 명세서에서 “검은콩 추출물”이란, 다양한 추출 방법을 통해 검은콩에서 추출된 물질을 총칭하며, 예를 들어, 유기 용매 등을 이용하여 추출된 물질, 추출된 물질에 대한 다양한 분획물 등을 포함한다. As used herein, the term " black bean " refers to soybeans having a black color in the color of the grain shell. Examples of the black beans include, but are not limited to, seaweed, seomyeotae, and black soybeans. The name of black bean can be variously called by region, classification, influence of dialect. As used herein, the term "black bean extract" refers to a substance extracted from black beans through various extraction methods, and includes, for example, a substance extracted using an organic solvent or the like, various fractions of the extracted substance, and the like .
본 명세서에서 "유색콩(colored-bean)"이란, 낟알 껍질의 색이 짙은 빛깔을 띠는 콩을 총칭하며, 검은색 뿐만 아니라 적색, 황색 또는 청색 등의 빛깔을 띠는 콩을 포괄한다. 상기 유색콩의 예로는, 서리태, 서목태, 흑태, 황태, 푸르대콩, 강낭콩, 얼룩강낭콩, 울타리콩, 녹두, 적두, 거두, 콩나물콩, 선비콩 또는 대두 등을 들 수 있으나, 이에 제한되는 것은 아니다. 유색콩의 명칭은 지역이나 분류, 방언의 영향 등에 의해 다양하게 불릴 수 있다. 본 명세서에서 "유색콩 추출물"이란, 다양한 추출 방법을 통해 유색콩에서 추출된 물질을 총칭하며, 예를 들어, 유기 용매 등을 이용하여 추출된 물질, 추출된 물질에 대한 다양한 분획물 등을 포함한다.As used herein, the term "colored-bean" refers to soybeans having a dense color of grain shells, and includes not only black but also beans having a color such as red, yellow or blue. Examples of the above-mentioned colored beans include, but are not limited to, Seoritae, Seomotei, Black tea, Yellowtail, Fuda bean, Kidney bean, Stain kidney bean, Fence bean, Mung bean, Red bean, Reed, Soybean bean, Soybean bean or Soybean . The names of colored beans can be variously called by region, classification, and the influence of dialects. In the present specification, the term "colored bean extract" refers to a substance extracted from colored beans through various extraction methods, and includes, for example, a substance extracted using an organic solvent or the like, various fractions of the extracted substance, and the like .
본 발명의 일측면에서, 측백(Biota orientalis)은 측백나무과에 속하는 측백나무의 어린 가지 또는 잎을 포함한다. 측백 추출물은 모발을 검게 하고 육모를 촉진한다. 아마씨는 아마인이라고도 하며, 아마(Linum usitatissimum .)의 종자를 의미한다. 아마씨 추출물에는 여성 호르몬이 다량 포함되어 있으므로, 남성 호르몬에 의한 탈모 현상을 감소시킬 수 있다. 감초는 감초(Glycyrrhiza uralensis)의 잎, 줄기 또는 뿌리를 모두 포함하는 개념이다. 감초 추출물은 모근에 작용하여 모발의 발육을 억제하는 DHT의 혈중 농도를 낮추는 이소플라본(isoflavone)을 다량 포함하여, 탈모 방지 및 육모 촉진 효과를 나타낼 수 있다.In one aspect of the present invention, the Biota orientalis comprises a young branch or leaf of a cinnabar tree belonging to the Quercus variabilis. Extracts of horsetail will make hair black and promote hair growth. Flaxseed is also known as flax seed, flax (Linum usitatissimum . ) Seeds. Since flaxseed extract contains a large amount of female hormone, it can reduce the hair loss caused by male hormone. Licorice is licorice ( Glycyrrhiza uralensis ) leaves, stems, or roots. The licorice extract contains a large amount of isoflavone which acts on the hair follicle to lower the blood concentration of DHT, which inhibits the hair growth, and can exhibit hair loss prevention and hair growth promoting effect.
측백 추출물, 아마씨 추출물 및 감초 추출물은 각각 측백, 아마씨 또는 감초를 물 또는 탄소수 1 내지 5의 저급 알코올을 포함하는 알코올로 당업계의 통상적인 방법을 이용하여 추출한 추출물일 수 있다. 예를 들어, 구체적으로, 상기 추출물은 원료 1 ㎏당 0.1 내지 10ℓ, 구체적으로 0.5 내지 7ℓ의 물을 추출 용매로서 가하고 20 내지 90 ℃에서, 구체적으로 70 내지 80 ℃에서 3 내지 6시간, 구체적으로 4시간 동안 환류하여 추출한 추출물일 수 있다.Flaxseed extract, flaxseed extract and licorice extract may each be an extract obtained by using a conventional method in the art, such as flaxseed, flaxseed or licorice, with an alcohol containing water or a lower alcohol having 1 to 5 carbon atoms. For example, specifically, the extract is prepared by adding 0.1 to 10 L, specifically 0.5 to 7 L of water per 1 kg of the raw material as an extraction solvent, at 20 to 90 DEG C, specifically at 70 to 80 DEG C for 3 to 6 hours, It may be an extract obtained by refluxing for 4 hours.
본 발명의 일측면에 따른 조성물은 저농도의 유기 용매로 추출한 콩 추출물과 함께 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 더 포함함으로써, 시너지 작용을 통해 탈모를 방지하고 육모를 촉진함에 있어 매우 우수한 효과를 발휘할 수 있다. 구체적으로 상기 조성물은 모유두 세포의 활성화를 유도하여 증식을 촉진하고, 모세 혈관을 확장시키며 혈액 내 산화 성분을 제거하고 혈중 중성 지질을 감소시켜 혈액 순환을 활성화하여 모근에 영양을 공급한다. 또한 휴지기의 모발에 대해 성장기로의 이행을 촉진한다. 이와 같은 작용을 통해 상기 조성물은 탈모를 방지하고 육모를 촉진하는 효과가 뛰어나며, 나아가 모발의 노화를 방지하고 모발의 윤기를 높이며, 모근을 강화하여 모발 건강을 증진시키는 효과가 탁월하다.The composition according to one aspect of the present invention further comprises a soybean extract extracted with a low concentration of an organic solvent and at least one extract selected from the group consisting of a panax, an flaxseed extract and a licorice extract to prevent hair loss through synergistic action, A very excellent effect can be exerted in promoting. Specifically, the composition promotes the activation of the dermal papilla cells to promote proliferation, enlarges the capillary blood vessels, removes the oxidation components in the blood, and reduces the neutral lipids in the blood, thereby activating blood circulation to nourish the hair follicles. It also promotes the transition to growth period for the hair of the resting period. Through such an action, the composition is excellent in the effect of preventing hair loss and accelerating hair growth, further preventing the aging of the hair, increasing the shine of the hair, and strengthening the hair root to enhance the hair health.
본 발명의 일측면에 따른 조성물은 조성물 전체 중량을 기초로 0.001 내지 90 중량%, 구체적으로 1.0 내지 70 중량%, 더 구체적으로 5.0 내지 50 중량%의 콩 추출물을 포함한다. 본 발명의 일측면에 따른 조성물은 조성물 전체 중량을 기초로 0.001 내지 90 중량%, 구체적으로 1.0 내지 70 중량%, 더 구체적으로 5.0 내지 50 중량%의 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 포함한다. 상기 중량%로 포함되는 경우 본 발명의 의도한 효과를 나타내기에 적절할 뿐만 아니라, 조성물의 안정성 및 안전성을 모두 만족할 수 있으며, 비용 대비 효과의 측면에서도 상기 범위로 포함되는 것이 적절할 수 있다.The composition according to one aspect of the present invention comprises from 0.001 to 90% by weight, specifically from 1.0 to 70% by weight, more particularly from 5.0 to 50% by weight, of soybean extract, based on the total weight of the composition. The composition according to one aspect of the present invention comprises from 0.001 to 90% by weight, in particular from 1.0 to 70% by weight, more particularly from 5.0 to 50% by weight, of a scurf extract, flaxseed extract and licorice extract, And one or more extracts selected. When it is contained in the above weight percentage, it is not only suitable for exhibiting the intended effect of the present invention but also can satisfy both the stability and safety of the composition, and may be suitably included in the above range in terms of cost effectiveness.
본 발명의 일측면에서, 조성물은 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 10 : 1 내지 1 : 10, 구체적으로 5 : 1 내지 1 : 5, 더 구체적으로 3 : 1 내지 1 : 3의 중량비로 포함한다. 상기 비율로 포함되는 경우 본 발명의 의도한 효과를 나타내기에 적절할 뿐만 아니라, 조성물의 안정성 및 안전성을 모두 만족할 수 있으며, 비용 대비 효과의 측면에서도 상기 범위로 포함되는 것이 적절할 수 있다.In one aspect of the present invention, the composition comprises at least one extract selected from the group consisting of soybean extract, flax extract, flaxseed extract and licorice extract at a ratio of 10: 1 to 1:10, specifically 5: 1 to 1: 5, 3: 1 to 1: 3. When included in the above ratio, it is not only suitable for exhibiting the intended effect of the present invention but also can satisfy both stability and safety of the composition, and may be suitably included in the above range in terms of cost effectiveness.
본 발명의 일측면은 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 포함하는 조성물을 포함하는 화장품 조성물을 제공한다.One aspect of the present invention provides a cosmetic composition comprising a composition comprising a soybean extract, an extract from a foliage, a flaxseed extract, and at least one extract selected from the group consisting of licorice extract.
상기 화장품 조성물은 국소 적용에 적합한 모든 제형으로 제공될 수 있다. 예를 들면, 용액, 수상에 유상을 분산시켜 얻은 에멀젼, 유상에 수상을 분산시켜 얻은 에멀젼, 현탁액, 고체, 겔, 분말, 페이스트, 포말(foam) 또는 에어로졸 조성물의 제형으로 제공될 수 있다. 이러한 제형의 조성물은 당해 분야의 통상적인 방법에 따라 제조될 수 있다.The cosmetic composition may be provided in any formulation suitable for topical application. For example, it may be provided as a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an oil phase in water, a suspension, a solid, a gel, a powder, a paste, a foam or an aerosol composition. Compositions of such formulations may be prepared according to conventional methods in the art.
상기 화장품 조성물은 상기한 물질 이외에 주 효과를 손상시키지 않는 범위 내에서, 바람직하게는 주 효과에 상승 효과를 줄 수 있는 다른 성분들을 함유할 수 있다. 본 발명에 따른 화장품 조성물은 비타민, 고분자 펩티드, 고분자 다당 및 스핑고 지질로 이루어진 군에서 선택된 물질을 포함할 수 있다. 또한 본 발명에 따른 화장품 조성물은 보습제, 에몰리언트제, 계면 활성제, 자외선 흡수제, 방부제, 살균제, 산화 방지제, pH 조정제, 유기 및 무기 안료, 향료, 냉감제 또는 제한(制汗)제를 포함할 수 있다. 상기 성분의 배합량은 본 발명의 목적 및 효과를 손상시키지 않는 범위 내에서 당업자가 용이하게 선정 가능하며, 그 배합량은 조성물 전체 중량을 기준으로 0.01~5 중량%, 구체적으로 0.01~3 중량%일 수 있다.The cosmetic composition may contain, in addition to the above-mentioned substances, other ingredients which can give rise to a synergistic effect on the main effect, so long as they do not impair the main effect. The cosmetic composition according to the present invention may comprise a material selected from the group consisting of vitamins, high molecular peptides, high molecular weight polysaccharides and sphingolipids. The cosmetic composition according to the present invention may also contain a moisturizing agent, an emollient agent, a surfactant, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjusting agent, an organic and inorganic pigment, a fragrance, . The blending amount of the above components can be easily selected by those skilled in the art within a range not to impair the objects and effects of the present invention. The blending amount thereof can be 0.01 to 5% by weight, specifically 0.01 to 3% by weight based on the total weight of the composition have.
본 발명의 일측면은 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 포함하는 조성물을 포함하는 식품 조성물을 제공한다.One aspect of the present invention provides a food composition comprising a composition comprising a soybean extract, a cottonseed extract, a flaxseed extract, and at least one extract selected from the group consisting of licorice extract.
상기 식품 조성물의 제형은 특별히 한정되지 않으나, 예를 들어, 정제, 과립제, 드링크제, 캐러멜 등으로 제형화될 수 있다. 각 제형의 식품 조성물은 유효 성분 이외에 해당 분야에서 통상적으로 사용되는 성분들을 제형 또는 사용 목적에 따라 당업자가 어려움 없이 적의 선정하여 배합할 수 있으며, 다른 성분과 동시에 적용할 경우 상승 효과가 일어날 수 있다.The formulation of the food composition is not particularly limited, but may be formulated into tablets, granules, drinks, caramels, and the like. The food composition of each formulation may be formulated by the person skilled in the art without difficulty, depending on the purpose of formulation or use, in addition to the active ingredient, and the synergistic effect may occur when the composition is applied simultaneously with other ingredients.
상기 유효 성분의 투여량 결정은 당업자의 수준 내에 있으며, 이의 1일 투여 용량은 예를 들어 0.1mg/kg/일 내지 5000mg/kg/일, 보다 구체적으로는 50 mg/kg/일 내지 500 mg/kg/일이 될 수 있으나, 이에 제한되지 않으며, 투여하고자 하는 대상의 연령, 건강 상태, 합병증 등의 다양한 요인에 따라 달라질 수 있다.The dosage of the active ingredient is within the level of those skilled in the art and its daily dose is, for example, from 0.1 mg / kg / day to 5000 mg / kg / day, more specifically from 50 mg / kg / day, but it is not limited thereto, and may be varied depending on various factors such as the age, health condition, and complications of the subject to be administered.
본 발명의 일측면은 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물로 이루어진 군에서 선택된 하나 이상의 추출물을 포함하는 조성물을 포함하는 약학 조성물을 제공한다. 본 발명의 다른 일측면에서, 상기 약학 조성물은 탈모를 예방 또는 치료하고, 육모를 촉진하며, 모발 건강을 증진하는 효과를 나타낼 수 있다.One aspect of the present invention provides a pharmaceutical composition comprising a composition comprising a soybean extract, a flaxseed extract, a flaxseed extract, and at least one extract selected from the group consisting of licorice extract. In another aspect of the present invention, the pharmaceutical composition may exhibit an effect of preventing or treating hair loss, promoting hair growth, and enhancing hair health.
본 발명의 일측면에 따른 약학 조성물은 경구, 비경구, 직장, 국소, 경피, 정맥 내, 근육 내, 복강 내, 피하 등으로 투여될 수 있다. 경구 투여를 위한 제형은 정제(錠劑), 환제(丸劑), 연질 및 경질 캅셀제, 과립제(顆粒劑), 산제, 세립제, 액제, 유탁제(乳濁濟) 또는 펠렛제일 수 있으나, 이에 제한되는 것은 아니다. 비경구 투여를 위한 제형은 용액제, 현탁제, 유액제, 겔, 주사제, 점적제, 좌제(坐劑), 패취 또는 분무제일 수 있으나, 이에 제한되는 것은 아니다. 상기 제형은 당해 분야의 통상적인 방법에 따라 용이하게 제조될 수 있으며, 계면 활성제, 부형제, 수화제, 유화 촉진제, 현탁제, 삼투압 조절을 위한 염 또는 완충제, 착색제, 향신료, 안정화제, 방부제, 보존제 또는 기타 상용하는 보조제를 적당히 사용할 수 있다.The pharmaceutical composition according to one aspect of the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, and the like. Formulations for oral administration may be in the form of tablets, pills, soft and hard capsules, granules, powders, granules, solutions, emulsions or pellets, It is not. Formulations for parenteral administration may be, but are not limited to, solutions, suspensions, emulsions, gels, injections, drops, suppositories, patches or spray formers. The formulations may be readily prepared according to conventional methods in the art and may be prepared by conventional means including, but not limited to, surfactants, excipients, wetting agents, emulsifying accelerators, suspending agents, salts or buffers for controlling osmotic pressure, colorants, spices, stabilizers, preservatives, Other commonly used adjuvants may be used.
본 발명의 일측면에 따른 약학 조성물의 유효 성분은 투여 받을 대상의 연령, 성별, 체중, 병리 상태 및 그 심각도, 투여 경로 또는 처방자의 판단에 따라 달라질 것이다. 이러한 인자에 기초한 적용량 결정은 당업자의 수준 내에 있으며, 이의 1일 투여 용량은 예를 들어 0.1mg/kg/일 내지 5000mg/kg/일, 보다 구체적으로는 50 mg/kg/일 내지 500 mg/kg/일이 될 수 있으나, 이에 제한되는 것은 아니다.The effective ingredients of the pharmaceutical composition according to one aspect of the present invention will vary depending on the age, sex, weight, pathological condition and severity of the subject to be administered, route of administration, or judgment of the prescriber. Determination of the amount of application based on these factors is within the level of ordinary skill in the art and its daily dose is, for example, from 0.1 mg / kg / day to 5000 mg / kg / day, more specifically from 50 mg / kg / day to 500 mg / / Day, but is not limited thereto.
이하, 비교예, 실시예 및 시험예를 들어 본 발명의 구성 및 효과를 보다 구체적으로 설명한다. 그러나 이들 실시예, 비교예 및 시험예는 본 발명에 대한 이해를 돕기 위해 예시의 목적으로만 제공된 것일 뿐 본 발명의 범주 및 범위가 그에 의해 제한되는 것은 아니다.Hereinafter, the constitution and effects of the present invention will be described in more detail with reference to comparative examples, examples and test examples. However, these examples, comparative examples and test examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope and scope of the present invention are not limited thereto.
[비교예] 콩 추출물의 제조[Comparative Example] Production of soybean extract
건조된 서리태 1kg을 50℃의 온도에서 각각 10%, 20%, 50% 및 70%(v/v)의 (v/v)의 에탄올 용액 10L에 침지하여 5시간 동안 3회 환류 추출한 다음, 상온에서 12시간 동안 방치하였다. 추출액을 여과하여 감압 농축하고 동결 건조하여 분말 시료를 제조하였다. 수율은 7~20%이었으며, 조제된 분말은 사용시까지 저온에서 보관하였다.1 kg of dried seaweed was immersed in 10 L of an ethanol solution of 10%, 20%, 50% and 70% (v / v) respectively at a temperature of 50 캜 and refluxed for 3 hours for 5 hours. Lt; / RTI > for 12 hours. The extract was filtered, concentrated under reduced pressure and lyophilized to prepare a powder sample. The yield was 7 ~ 20% and the prepared powder was stored at low temperature until use.
[실시예] 복합 추출물의 제조[Examples] Preparation of complex extract
비교예 중 20% 에탄올로 추출한 콩 추출물과 물로 추출한 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 혼합하여 실시예 1 내지 6을 제조하였다. 각 실시예가 포함하는 유효 성분 및 각 성분의 중량비는 아래와 같다.Examples 1 to 6 were prepared by mixing at least one of soybean extract extracted with 20% ethanol and water extract, flaxseed extract and licorice extract. The active ingredients and the weight ratios of the respective components contained in each example are as follows.
[시험예 1] 모유두 세포 증식 촉진 효과 평가[Test Example 1] Evaluation of promoting effect of proliferation of dermal papilla cells
쥐수염 모유두세포(Rat Vibrissa dermal papillae cell; 온도 민감 T 항원을 인코딩한 폴리오마바이러스 라지 T 유전자(polyomavirus large T gene)를 PVG 쥐수염 모유두세포(vibrissa dermal papilla cell)에 트랜스펙션하여 만든 PVGDPLTt sa 6이다. 이하, DP 세포라 한다.)를 이용하여 본 발명에 따른 조성물의 모유두 세포 증식 촉진 효과를 평가하였다.Rat Vibrissa dermal papillae cell (PVGDPLTT sa) transfected with polyomavirus large T gene encoding temperature-sensitive T antigen into PVG mouse vibrissa dermal papilla cell 6. Hereinafter referred to as DP cells), the effect of promoting the growth of the dermal papilla cells of the composition according to the present invention was evaluated.
먼저 DP 세포를 96-웰 플레이트에 한 웰 당 약 104 세포/웰의 농도가 되도록 준비하였다. 실시예 1 내지 6 및 비교예를 DMSO(Dimethyl sulfoxide) 또는 에탄올에 각각 용해시킨 후, 5% FBS 세럼 농도를 가지는 DMEM 배지로 순차적 희석(serial dilution)하여 최종 농도가 10ppm이 되도록 하였다. 비교예로는 20% 에탄올로 추출한 콩 추출물을 사용하였다. 실시예 1 내지 6 및 비교예가 첨가된 배지 200㎕를 각각 웰 당 첨가한 후, 37℃, 5% CO2 배양기에서 약 3일간 배양하였다. 2㎎/㎖의 농도로 조제된 MTT 용액을 각 웰 당 50㎕씩 첨가한 후, 동일한 배양기에서 4시간 동안 방치하였다. MTT 시약이 세포 내 미토콘드리아에 흡수되었다고 판단되면 상등액을 제거하고, DMSO를 150㎕ 첨가한 다음, 10분간 교반하여 균일하게 프로마잔(formazan) 염색(dye)을 녹여내었다. 그런 다음 ELISA 리더를 이용하여 515nm 파장에서 O.D. 값을 측정하고, 미리 만들어둔 표준 곡선에 맞추어 세포 수를 측정하였다. 측정한 세포 수를 기초로 실시예 1 내지 6 및 비교예의 모유두 세포 증식 촉진능(%)을 계산하고 그 결과를 아래 표에 나타내었다.DP cells were first prepared to a concentration of about 10 4 cells / well per well in a 96-well plate. Examples 1 to 6 and Comparative Example were dissolved in DMSO (dimethyl sulfoxide) or ethanol, and then serial dilution was performed with DMEM medium having a 5% FBS serum concentration to obtain a final concentration of 10 ppm. As a comparative example, soybean extract extracted with 20% ethanol was used. 200 占 퐇 of the medium to which Examples 1 to 6 and Comparative Example were added was added to each well, followed by incubation at 37 占 폚 in a 5% CO 2 incubator for about 3 days. MTT solution prepared at a concentration of 2 mg / ml was added in an amount of 50 占 퐇 / well, followed by incubation in the same incubator for 4 hours. When it was judged that the MTT reagent was absorbed into the intracellular mitochondria, the supernatant was removed, 150 μl of DMSO was added, and the mixture was stirred for 10 minutes to uniformly dissolve the formazan dye. The OD value at 515 nm was measured using an ELISA reader, and the number of cells was measured according to a standard curve prepared beforehand. Based on the measured number of cells, the ability of the dermal papilla growth promoting (%) in Examples 1 to 6 and Comparative Example was calculated, and the results are shown in the table below.
상기에서 볼 수 있듯이, 콩 추출물만을 포함하는 비교예에 비해 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 실시예 1 내지 6의 모유두 세포 증식 촉진 효과가 더 우수하였다. 특히 콩 추출물, 측백 추출물 및 감초 추출물을 포함하는 실시예 5의 모유두 세포 증식 촉진 효과가 가장 우수하였다. 따라서 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물은 모유두 세포 증식 촉진에 있어 시너지 효과를 가지므로 탈모를 방지하고 육모를 촉진하며 나아가 모발 건강을 증진하는 효과가 더욱 우수함을 알 수 있다.As can be seen from the above, the effect of promoting the growth of the papilla cells in Examples 1 to 6 including at least one of the soybean extract, the sage extract, the flaxseed extract and the licorice extract was better than the comparative example including only the soybean extract. In particular, the effect of promoting the growth of the papilla cells of Example 5, which contained soybean extract, horsetail extract and licorice extract, was the most excellent. Therefore, a composite composition comprising at least one of soybean extract, bark extract, flaxseed extract and licorice extract has a synergistic effect in promotion of papillary cell proliferation, thereby preventing hair loss, promoting hair growth, and further enhancing hair health. .
[시험예 2] 모세혈관 확장 효과 평가[Test Example 2] Capillary expansion effect evaluation
K+ 채널이 열리면 미토제네시스(mitogenesis)가 활성화되고 혈관 평활근(vascular smooth muscle)이 이완되면서 혈관이 확장된다. 한편, K+ 채널이 차단되면 NIH3T3 섬유아세포(fibroblast)의 증식이 저해된다고 알려져 있다. 따라서 시료 처리에 의해 NIH3T3 섬유아세포의 성장이 촉진되면, K+ 채널이 열린다고 볼 수 있고, 나아가 혈관 확장이 촉진된다고 볼 수 있다.When the K + channel is opened, mitogenesis is activated and the vascular smooth muscle relaxes and blood vessels expand. On the other hand, it is known that inhibition of NIH3T3 fibroblast proliferation is inhibited when K + channel is blocked. Therefore, when the growth of NIH3T3 fibroblasts is promoted by the sample treatment, it can be seen that the K + channel is opened and further the vasodilation is promoted.
먼저 NIH3T3 섬유아세포를 24-웰 배양 플레이트에 104 세포/웰의 농도로 시드(seed)하고, 10% FCS(fetal calf serum) 및 2mM L-글루타민을 포함하며 항생제를 포함하지 않는 DMEM 배지에서 24시간 배양하였다. 이후 배양 배지를 각각 실시예 1 내지 6 및 비교예가 첨가된 배지로 교체하고 72시간 배양하였다. 실시예 1 내지 6 및 비교예가 첨가된 배지 제조 방법은 시험예 1과 같으며, 비교예로는 20% 에탄올로 추출한 콩 추출물을 사용하였다. 배지를 제거한 후 PBS(Ca2 +/Mg2 + 없음)로 세척하고, 0.5ml TE(trypsin-ethylenediamine tetraacetic acid)로 처리한 후 배양하였다. 10% FCS가 포함된 DMEM를 가하고 세포를 취한 다음 EP 튜브에 담아 6000rpm에서 원심 분리하였다. 상등액을 제거하고 남은 세포액을 100㎕의 PBS에 현탁한 후 혈구 계산기(hemocytometer)를 사용하여 세포 수를 측정하였다. 이를 기초로 실시예 1 내지 6 및 비교예의 모세혈관 확장능을 계산하여 아래 표에 나타내었다.First, NIH3T3 fibroblasts were seeded at a concentration of 10 4 cells / well in a 24-well culture plate and cultured in DMEM medium containing 10% FCS (fetal calf serum) and 2 mM L-glutamine, Time. Then, the culture medium was replaced with the medium to which each of Examples 1 to 6 and Comparative Example was added, and cultured for 72 hours. The culture medium to which Examples 1 to 6 and Comparative Examples were added was the same as that of Test Example 1, and as a comparative example, soybean extract extracted with 20% ethanol was used. After removal of the medium and washed with PBS (Ca + 2 / Mg + 2 N), treated with 0.5ml TE (trypsin-ethylenediamine tetraacetic acid ) and cultured. DMEM containing 10% FCS was added and cells were taken and centrifuged at 6000 rpm in an EP tube. The supernatant was removed, and the remaining cell lysate was suspended in 100 μl of PBS, and then the number of cells was measured using a hemocytometer. Based on this, the capillary vasodilating capacity of Examples 1 to 6 and Comparative Example was calculated and shown in the table below.
상기에서 볼 수 있듯이, 콩 추출물만을 포함하는 비교예에 비해 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 실시예 1 내지 6의 모세혈관 확장 효과가 더 우수하였다. 특히 콩 추출물, 측백 추출물 및 감초 추출물을 포함하는 실시예 5의 모세혈관 확장 효과가 가장 우수하였다. 따라서 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물은 두피 모세혈관의 혈액 순환 개선에 있어 시너지 효과를 가지므로, 모발 건강을 증진시키고 탈모의 진행을 억제하며 육모를 촉진하는 효과가 더욱 뛰어남을 알 수 있다.As can be seen from the above, the capillary vasodilating effect of Examples 1 to 6 including at least one of soybean extract, flax seed extract, flaxseed extract and licorice extract was superior to the comparative example including soybean extract alone. In particular, the capillary vasodilating effect of Example 5 including soybean extract, horsetail extract and licorice extract was the best. Therefore, a composite composition comprising at least one of a soybean extract, a flaxseed extract, a flaxseed extract and a licorice extract has a synergistic effect in improving circulation of the capillary blood vessels of the scalp, thereby enhancing hair health, inhibiting the progress of hair loss, It can be seen that the effect is more excellent.
[시험예 3] 모발 성장 촉진 효과 평가[Test Example 3] Evaluation of hair growth promoting effect
비교예의 20% 에탄올로 추출한 콩 추출물과 실시예 5를 이용하여 마우스의 모발 성장 촉진 효과를 평가하였다. 먼저 생후 47∼53일된 마우스(C57BL/6)의 등 부위 털을 일렉트릭 크립퍼(electric clipper)로 제거하였다. 상기 연령의 마우스 모발은 휴지기에 들어선 상태이므로 바로 성장하지 않는다는 특징을 가진다. 그 중 등 부위 피부가 양호한 마우스들을 골라 한 군당 5~7마리의 마우스가 포함되도록 3개의 군으로 나눈 후, 별도의 케이스에서 사육하였다. 비교예와 실시예 5가 각각 0.6%로 포함되도록 한 시리얼 사료를 식이를 통하여 자유 섭취하도록 하였다. 본 발명에 따른 유효 성분을 포함하지 않은 시리얼 사료를 섭취하도록 한 군을 대조군으로 하였다. 23일 후 각 군의 제모 부위 변화를 관찰하고 그 사진을 도 1에 나타내었다. 또한 제모 부위에 새로 성장한 각 마우스의 모발을 일렉트릭 크립퍼로 수거하여 무게를 측정하였다. 그 결과는 아래 표에 나타내었다.The soybean extract extracted with 20% ethanol of Comparative Example and Example 5 were used to evaluate the hair growth promoting effect of the mouse. First, the dorsal hairs of mice (C57BL / 6) that were 47 to 53 days old were removed with an electric clipper. Since the mouse hair of this age is in a resting state, it does not grow immediately. Among them, mice with good back skin were selected and divided into three groups so that 5 to 7 mice were included in each group, and then they were raised in a separate case. The cereal feeds, which were 0.6% and 0.6%, respectively, were freely ingested through diets. The control group was fed with a cereal feed containing no active ingredient according to the present invention. After 23 days, the change of the epilation area of each group was observed and the photograph is shown in Fig. In addition, hair of each newly-developed mouse on the hair removal area was collected by electric creepers and weighed. The results are shown in the table below.
상기에서 볼 수 있듯이, 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물을 적용한 경우는 양자 모두 적용하지 않은 경우뿐만 아니라 콩 추출물만을 포함하는 조성물을 적용한 경우보다 마우스 모발의 성장을 촉진시켰다. 이는 도 1에 나타나는 외관 및 표 4의 모발 무게를 통해 알 수 있다. 따라서 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물은 모발 성장 촉진 효과가 우수함을 알 수 있다.As can be seen from the above, when a composite composition comprising at least one of a soybean extract, a flaxseed extract, a flaxseed extract and a licorice extract was applied, Promoting growth. This can be seen from the appearance shown in FIG. 1 and the hair weight in Table 4. Therefore, it can be seen that the composite composition comprising at least one of soybean extract, horsetail extract, flaxseed extract and licorice extract has excellent hair growth promoting effect.
[시험예 4] 혈액의 항산화능 평가[Test Example 4] Evaluation of antioxidative capacity of blood
(1) 혈액 샘플의 채취 및 혈장의 분리(1) Collection of blood samples and separation of plasma
시험예 3이 종료되는 시점에 각 군 마우스의 안구 혈관에서 혈액 샘플을 200㎕씩 취하였으며 이를 원심 분리(3000rpm, 10분)하여 혈구와 혈장으로 분리하였다. 상등액을 취하여 1.7ml 마이크로 E-튜브에 담아 분석 직전까지 냉동 보관하였다.At the end of Test Example 3, 200 μl of a blood sample was taken from the ocular blood vessels of each group of mice and separated into blood cells and plasma by centrifugation (3000 rpm, 10 minutes). The supernatant was taken and placed in a 1.7 ml micro-E tube and stored frozen until just before analysis.
(2) 혈장의 자유기(free radical) 소거능 평가(2) Evaluation of plasma free radical scavenging ability
ABTS(2,2'-Azino-bis(3-ethylbenzthiazoline 6-sulfonic acid))를 pH 5.0인 0.05M의 인산염-구연산(phosphate-citrate) 버퍼에 최종 농도가 150M이 되도록 첨가하여 ABTS 용액을 제조하였다. 상기 ABTS 용액에 과산화수소(H2O2)와 과산화효소(메트마이오글로빈)를 각기 75M과 2.5M이 되도록 한 후 반응시켜 ABTS 라디칼을 생성시켰다. 각 군의 혈장 시료 20L를 각각 180L의 ABTS 라디칼 용액에 첨가하고 완전히 혼합한 후, 상온에서 차광을 시켜 60분간 반응시켰다. 반응이 완료된 후 600nm에서 시료의 흡광도를 측정하였다. 이와 동시에 pH 5.0인 0.05M의 인산염-구연산(phosphate-citrate) 버퍼에 트롤록스(trolox)의 최종 농도가 10mM, 2mM, 1mM, 100M, 10M가 되도록 첨가한 트롤록스 시료를 제조하였다. 상기 ABTS 라티칼 용액을 사용하여 위와 동일한 방법으로 트롤록스 시료를 반응시키고 흡광도를 측정하여 표준 곡선(standard curve)을 작성하였다. 이를 기준으로 각 군 시료의 흡광도 값을 TEAC(Trolox Equivalence Antioxidant Activity) 값으로 계산하였으며, 이를 아래 표에 나타내었다. TEAC는 시료의 자유기 소거능을 이와 동등한 활성을 발휘하는 트롤록스의 용량으로 표시해 주는 것으로 물질 간 항산화 활성의 상대적인 비교를 가능하게 해주는 수치이다.ABTS solution was prepared by adding ABTS (2,2'-Azino-bis (3-ethylbenzthiazoline 6-sulfonic acid)) to 0.05M phosphate-citrate buffer at pH 5.0 to a final concentration of 150M . The ABTS solution was prepared so that hydrogen peroxide (H 2 O 2 ) and peroxidase (methomoglobin) were 75 M and 2.5 M, respectively, and reacted to produce ABTS radicals. 20 L of plasma samples from each group were added to 180 L of ABTS radical solution, mixed thoroughly, and shaded at room temperature for 60 minutes. After completion of the reaction, the absorbance of the sample was measured at 600 nm. At the same time, a Trolox sample was added to 0.05 M phosphate-citrate buffer, pH 5.0, so that the final concentration of trolox was 10 mM, 2 mM, 1 mM, 100 M and 10 M, respectively. Using the ABTS Latical solution, the Trolox sample was reacted in the same manner as above, and the absorbance was measured to prepare a standard curve. Based on this, the absorbance value of each group sample was calculated as the TEAC (Trolox Equivalence Antioxidant Activity) value, which is shown in the table below. TEAC indicates the free radical scavenging ability of the sample in terms of the equivalent activity of trolox, which is a comparative value of antioxidant activity between substances.
상기에서 볼 수 있듯이, 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물을 적용한 경우는 아무 것도 적용하지 않은 경우뿐만 아니라 콩 추출물만을 포함하는 조성물을 적용한 경우보다 혈액에 대한 항산화능이 우수하였다. 따라서 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물은 혈액 내 산화 물질을 제거하여 혈액 순환을 개선함으로써 모발 건강을 증진시키고 탈모의 진행을 억제하며 육모를 촉진하는 효과가 더욱 뛰어남을 알 수 있다.As can be seen from the above, when a composite composition comprising at least one of a soybean extract, a cottonseed extract, a flaxseed extract and a licorice extract is applied, Antioxidant ability was excellent. Therefore, a composite composition containing at least one of soybean extract, flaxseed extract, flaxseed extract and licorice extract may improve hair health by removing oxidizing substances in blood to improve blood circulation, inhibit the progress of hair loss, and promote hair growth You can see that it is even better.
[시험예 5] 혈액 중성 지질 평가[Test Example 5] Evaluation of blood neutrality
시험예 4와 같은 방법으로 준비한 혈장에 대해 자동 혈액 화학 분석기(automatic blood chemistry analyzer, Selectra E; Vital Scientific)를 이용하여 혈중 중성 지질 분석을 실시하였다. 그 결과는 아래 표와 같다.Plasma prepared in the same manner as in Test Example 4 was subjected to blood neutral lipid analysis using an automatic blood chemistry analyzer (Selectra E, Vital Scientific). The results are shown in the table below.
상기에서 볼 수 있듯이, 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물을 적용한 경우는 아무 것도 적용하지 않은 경우뿐만 아니라 콩 추출물만을 포함하는 조성물을 적용한 경우보다 혈액의 중성 지질을 감소시키는 효과가 우수하였다. 따라서 콩 추출물과 측백 추출물, 아마씨 추출물 및 감초 추출물 중 하나 이상을 포함하는 복합 조성물은 혈액 내 중성 지질을 감소시켜 혈액 순환을 개선함으로써, 모발 건강을 증진시키고 탈모의 진행을 억제하며 육모를 촉진하는 효과가 더욱 뛰어남을 알 수 있다.As can be seen from the above, when a composite composition containing at least one of a soybean extract, a flaxseed extract, a flaxseed extract and a licorice extract is applied, The effect of reducing lipid was excellent. Therefore, a composite composition comprising at least one of a soybean extract, a flaxseed extract, a flaxseed extract and a licorice extract may improve blood circulation by reducing neutral lipids in the blood, thereby improving hair health, inhibiting the progress of hair loss, Is more excellent.
아래에 상기 조성물의 제형예를 설명하나, 이는 본 발명을 한정하는 것이 아니라 단지 구체적으로 설명하고자 함이다.Formulation examples of the composition are described below, but are not intended to limit the invention, but merely to illustrate them.
[제형예 1] 연질 캅셀제[Formulation Example 1] Soft capsule
서리태 추출물 100 mg, 대두 추출물 50 mg, 측백 추출물 50mg, 아마씨 추출물 50mg, 감초 추출물 50 mg, 대두유 180 mg, 팜유 2 mg, 팜경화유 8 mg, 황납 4 mg 및 레시틴 6 mg을 혼합하고, 통상의 방법에 따라 1 캡슐당 400 mg씩 충진하여 연질 캅셀제를 제조한다.50 mg of soybean extract, 50 mg of flaxseed extract, 50 mg of licorice extract, 50 mg of soybean oil, 180 mg of palm oil, 2 mg of palm oil, 8 mg of palm kernel oil, 4 mg of yellow pear extract and 6 mg of lecithin were mixed, , 400 mg per capsule was filled to prepare a soft capsule.
[제형예 2] 정제[Formulation Example 2] Tablets
울타리콩 추출물 100 mg, 측백 추출물 50mg, 감초 추출물 50mg, 포도당 100 mg, 전분 96 mg 및 마그네슘 스테아레이트 4 mg을 혼합하고 30% 에탄올을 40 mg 첨가하여 과립을 형성한 후, 60℃에서 건조하고 타정기를 이용하여 정제로 타정한다.The granules were prepared by mixing 100 mg of fence bean extract, 50 mg of fenugreek extract, 50 mg of licorice extract, 100 mg of glucose, 96 mg of starch and 4 mg of magnesium stearate and 40 mg of 30% ethanol, followed by drying at 60 ° C., And the tablet is tableted.
[제형예 3] 드링크제[Formulation Example 3] Drinking agent
서목태 추출물 100 mg, 아마씨 추출물 50mg, 감초 추출물 50mg, 포도당 10 g, 구연산 2 g 및 정제수 187.8 g을 혼합하고 병에 충진한다. 내용물의 최종 용량은 200 ml로 한다.100 mg of Seomunghae extract, 50 mg of flaxseed extract, 50 mg of licorice extract, 10 g of glucose, 2 g of citric acid and 187.8 g of purified water are mixed and filled into a bottle. The final volume of the contents should be 200 ml.
[제형예 4] 건강 식품[Formulation Example 4] Health food
서리태 추출물......................... 1000 ㎎ Seaweed extract ......................... 1000 mg
측백 추출물............................1000 ㎎Bark extract ............................ 1000 mg
비타민 혼합물 Vitamin mixture
비타민 A 아세테이트......................70 ㎍ Vitamin A Acetate ...................... 70 ㎍
비타민 E .............................. 1.0 ㎎ Vitamin E .............................. 1.0 mg
비타민 B1............................. 0.13 ㎎ Vitamin B1 ............................. 0.13 mg
비타민 B2 ............................ 0.15 ㎎ Vitamin B2 ............................ 0.15 mg
비타민 B6.............................. 0.5 ㎎ Vitamin B6 .............................. 0.5 mg
비타민 B12............................. 0.2 ㎍ Vitamin B12 ............................. 0.2 g
비타민 C................................ 10 ㎎ Vitamin C ................................ 10 mg
비오틴.................................. 10 ㎍ Biotin .................................. 10 μg
니코틴산아미드......................... 1.7 ㎎ Nicotinic acid amide ....................... 1.7 mg
엽산.................................... 50 ㎍ Folic acid .................................... 50 ㎍
판토텐산 칼슘.......................... 0.5 ㎎ Calcium pantothenate .......................... 0.5 mg
무기질 혼합물 Mineral mixture
황산제1철.............................. 1.75 ㎎ Ferrous sulfate .............................. 1.75 mg
산화아연............................... 0.82 ㎎ Zinc oxide ............................... 0.82 mg
탄산마그네슘........................... 25.3 ㎎ Magnesium carbonate ........................... 25.3 mg
제1인산칼륨.............................. 15 ㎎ Potassium Phosphate .............................. 15 mg
제2인산칼슘.............................. 55 ㎎ Secondary calcium phosphate .............................. 55 mg
구연산칼륨............................... 90 ㎎ Potassium citrate ............................... 90 mg
탄산칼슘................................ 100 ㎎ Calcium carbonate ................................ 100 mg
염화마그네슘............................ 24.8 ㎎ Magnesium chloride ............................ 24.8 mg
상기의 비타민 및 미네랄 혼합물의 조성비는 비교적 건강 식품에 적합한 성분을 혼합 조성하였지만, 그 배합비를 임의로 변형 실시하여도 무방하며, 통상의 건강 식품 제조 방법에 따라 상기의 성분을 혼합한 다음, 과립을 제조하고, 통상의 방법에 따라 건강 식품 조성물 제조에 사용할 수 있다.Although the composition ratio of the above-mentioned vitamin and mineral mixture is relatively mixed with the ingredient suitable for health food, the compounding ratio thereof may be arbitrarily changed, and the above ingredients may be mixed according to the ordinary health food manufacturing method, And can be used in the manufacture of a health food composition according to a conventional method.
[제형예 5] 크림 [Formulation Example 5] Cream
아래 표에 기재된 조성에 따라 통상적인 방법으로 크림을 제조한다.Creams are prepared by conventional methods according to the compositions listed in the table below.
본 발명이 속한 기술 분야에서 통상의 지식을 가진 자라면 상기 내용을 바탕으로 본 발명의 범주 내에서 다양한 응용 및 변형을 행하는 것이 가능할 것이다.It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (11)
상기 콩 추출물의 중량과, 상기 측백 추출물 및 감초 추출물의 중량의 합의 비가 1 : 1 초과 1 : 2 이하인, 탈모 방지 또는 육모 촉진용 조성물.
Soybean extract, horsetail extract and licorice extract as active ingredients,
Wherein the ratio of the weight of the soybean extract to the sum of the weight of the progeny extract and the weight of the licorice extract is 1: 1 or more and 1: 2 or less.
상기 콩 추출물의 중량과, 상기 측백 추출물 및 감초 추출물의 중량의 합의 비가 1 : 1 초과 1 : 2 이하인, 모발 건강 증진용 조성물.
Soybean extract, horsetail extract and licorice extract as active ingredients,
Wherein the ratio of the weight of the soybean extract to the sum of the weight of the progeny extract and the weight of the licorice extract is 1: 1 or more and 1: 2 or less.
콩은 서리태, 서목태, 흑태, 황태, 푸르대콩, 강낭콩, 얼룩강낭콩, 울타리콩, 녹두, 적두, 거두, 콩나물콩, 선비콩 및 대두로 구성된 군으로부터 선택된 하나 이상을 포함하는 조성물.
3. The method according to claim 1 or 2,
Wherein the soybean comprises at least one member selected from the group consisting of Seolite, Seomyoe, Blackberry, Prunus, Furdae bean, Kidney bean, Stain kidney bean, Fence bean, Green bean, Red bean, Reed, Bean sprouts bean, Sun bean and Soybean.
조성물은 조성물의 전체 중량을 기초로 0.001 내지 90 중량%의 콩 추출물을 포함하는 조성물.
3. The method according to claim 1 or 2,
Wherein the composition comprises from 0.001 to 90% by weight of soy extract based on the total weight of the composition.
조성물은 조성물의 전체 중량을 기초로 0.001 내지 90 중량%의 측백 추출물 및 감초 추출물을 포함하는 조성물.
3. The method according to claim 1 or 2,
Wherein the composition comprises from 0.001 to 90% by weight of a scurf extract and a licorice extract, based on the total weight of the composition.
조성물은 두피의 혈액 순환을 개선하여 모근에 영양을 공급하는 조성물.
3. The method according to claim 1 or 2,
The composition improves the blood circulation of the scalp and nourishes the hair follicle.
콩 추출물은 1% 내지 70%(v/v)의 C1~C5 알코올 추출물인 조성물.
3. The method according to claim 1 or 2,
The soybean extract is a C 1 to C 5 alcohol extract of 1% to 70% (v / v).
C1~C5 알코올은 메탄올, 에탄올, 이소프로필알코올, n-프로필알코올, n-부탄올 및 이소부탄올로 구성된 군으로부터 선택된 하나 이상을 포함하는 조성물.
8. The method of claim 7,
Wherein the C 1 to C 5 alcohol comprises at least one selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol.
7. A cosmetic composition comprising the composition according to any one of claims 1 to 6.
A food composition comprising the composition according to claims 1 or 2.
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| KR102073337B1 (en) | 2018-09-21 | 2020-03-02 | (주)에이치피앤씨 | Composition comprising the extract of ternstroemia kwangtungensis for preventing of hair loss or promoting hair growth |
| CN115778882A (en) * | 2023-02-09 | 2023-03-14 | 北京普世安生物科技有限公司 | Hair-growing essence and preparation method thereof |
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| KR20100080991A (en) * | 2009-01-05 | 2010-07-14 | (주)아모레퍼시픽 | Hair cosmetic composition for strengthening hair root |
| KR101032426B1 (en) * | 2009-04-10 | 2011-05-03 | 박현정 | Shampoo composition containing oriental medicine and manufacturing method thereof |
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| KR20100080991A (en) * | 2009-01-05 | 2010-07-14 | (주)아모레퍼시픽 | Hair cosmetic composition for strengthening hair root |
| KR101032426B1 (en) * | 2009-04-10 | 2011-05-03 | 박현정 | Shampoo composition containing oriental medicine and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102073337B1 (en) | 2018-09-21 | 2020-03-02 | (주)에이치피앤씨 | Composition comprising the extract of ternstroemia kwangtungensis for preventing of hair loss or promoting hair growth |
| CN115778882A (en) * | 2023-02-09 | 2023-03-14 | 北京普世安生物科技有限公司 | Hair-growing essence and preparation method thereof |
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