CN115778882A - Hair-growing essence and preparation method thereof - Google Patents
Hair-growing essence and preparation method thereof Download PDFInfo
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Abstract
The application relates to the technical field of cosmetics, and particularly discloses a hair-growing essence and a preparation method thereof. The hair-growing essence provided by the application comprises a plant extract and a bacteriostatic agent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract; the application also provides a preparation method of the hair growth essence. The hair-growing essence provided by the application can accelerate scalp blood circulation, activate and repair scalp hair follicle tissues, and further promote hair growth.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a hair-growing essence and a preparation method thereof.
Background
The hair is a very important characteristic of human appearance, and in recent years, people attach more importance to the personal image problem, and every person wants to have a dark and dense hair. However, modern young people often cause hair loss and hair loss due to the problems of irregular diet and work, huge living pressure and the like, so that a lot of people can slightly loose hair and even fall bald in the age, which not only can affect the appearance of the people, but also can cause certain trauma to the psychology of the people, attack personal confidence and lead the people to generate self-inferior psychology.
The research finds that the hair rarity and the alopecia are mainly caused by the following reasons: firstly, the ecological scalp of a human body is deteriorated, so that the scalp environment is disordered, and hair follicles are loosened or blocked; secondly, the metabolism in the body is disturbed, so that the sebaceous gland is stimulated to secrete vigorously, a great amount of grease is caused to press the root of the hair, the blood and nutrition supply required by the hair is blocked, and the seborrheic alopecia is caused; and thirdly, the lack of trace elements causes malnutrition of hair follicles and difficulty in hair growth.
Therefore, it is urgently needed to provide a hair restorer which can improve scalp environment, activate hair follicle tissues and promote hair follicle restoration so as to solve the problem of rare hair of modern young people.
Disclosure of Invention
It is effective in improving scalp environment, activating hair follicle tissue, and promoting hair growth. The application provides a hair-growing essence and a preparation method thereof.
In a first aspect, the present application provides a hair growth essence, which adopts the following technical scheme:
a hair growth essence comprises plant extract and bacteriostatic agent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
The hair growth essence provided by the application contains various plant extracts and bacteriostats, and the plant extracts can promote blood circulation of scalp, activate hair follicle tissues of scalp, accelerate absorption efficiency of the scalp on nutrient substances and further improve hair growth rate; the bacteriostatic agent can prevent the growth of bacteria in the scalp, thereby improving the scalp environment and providing beneficial space for hair growth. In the related art, the geranium contains a substance of 'champagne', which can be dyed into dark brown under the action of iron salt, so that the geranium is commonly used for preparing hair dye; hibiscus sabdariffa contains abundant proteins, organic acids, vitamin C, various amino acids and natural pigments, is commonly used for preparing traditional Chinese medicines to regulate blood pressure and improve sleep, and is also used in shampoo to achieve the effects of removing oil and relieving itching; however, the research of the inventor of the application finds that the geranium extract and the roselle extract can stimulate and smooth hair follicle tissues of scalp, promote the transformation of hair follicles from a resting period to a growing period, and further realize hair growth. Experiments prove that the mulberry extract, the geranium extract as the cacumen biotae extract, the roselle extract and other extracts are added in the range, the self action of each plant extract and the synergistic interaction among the extracts can be effectively exerted, the proliferation and differentiation of hair follicle stem cells in a hair follicle matrix are activated, and a good hair growth effect can be further obtained.
The geranium extract can inhibit the breeding of scalp germs, stimulate and smoothen hair follicle tissues of the scalp, promote the transformation of hair follicles from a resting period to a growing period, and further promote the growth of the hair. The roselle extract is an active substance extracted from dried calyx and bract of roselle, contains abundant proteins, organic acids, vitamins and mineral substances required by a human body, also contains anthocyanin with remarkable antioxidant function, hibiscus acid and the like, can well nourish scalp and hair follicles, and further accelerates the metabolism of the scalp; and the roselle extract also changes the contents of related factors such as a fibroblast growth factor, beta-catenin and the like in the hair growth process, prevents the hair follicles from entering a resting period, and increases the activity of the hair follicles, thereby promoting the hair growth. The cacumen biotae extract can promote scalp blood circulation and smoothen scalp, so that nutrient components are better absorbed by hair roots, hair stems are stimulated and nursed, normal growth of hair is promoted, and the effects of hair growth and hair nourishing are achieved. The Delphinium extract can promote blood vessel flow around hair follicle, increase nutrition and oxygen supply of hair follicle cells, and reduce alopecia. The mulberry extract contains various amino acids and minerals, and can not only blacken hair, but also provide nutrients for scalp. The pine needle extract is extracted from pine needles, and is rich in flavonoids, vitamins, amino acids and minerals, so that the pine needle extract can activate blood circulation of scalp, and has certain stimulation effect on hair follicle tissues, thereby promoting hair growth. The peony root extract and cactus extract have the effects of moisturizing, cleaning, resisting bacteria and relieving, and can moisten scalp, provide nutrients for scalp and promote hair growth.
Preferably, the plant extract comprises the following components in parts by weight: 1.4-2.1 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
In a specific embodiment, the delphinium extract is 0.5 parts, the mulberry extract is 0.85 parts, the pine needle extract is 0.5 parts, the cactus extract is 0.4 parts, and the peony root extract is 0.4 parts.
In some embodiments, the geranium extract may be present in an amount of 1.15-1.4 parts, 1.15-1.8 parts, 1.15-2.1 parts, 1.4-1.8 parts, or 1.8-2.1 parts by weight.
In a specific embodiment, the geranium extract may also be 1.15 parts, 1.4 parts, 1.8 parts or 2.1 parts by weight.
In some embodiments, the roselle extract may be present in an amount of 0.5 to 0.8 parts by weight or 0.8 to 1.15 parts by weight.
In a specific embodiment, the weight part of the roselle extract can also be 0.5 part, 0.8 part or 1.15 part.
In some embodiments, the cacumen biotae extract may be in an amount of 0.4-0.75 parts by weight or 0.75-1 parts by weight.
In a specific embodiment, the cacumen biotae extract can be further 0.4 part, 0.75 part or 1 part by weight.
Preferably, the plant extract comprises the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
The geranium extract can induce growth factors in the dermal papilla layer to promote the hair follicle to be converted to the anagen phase and inhibit the breeding of scalp germs; the roselle extract can change the content of related factors such as fibroblast growth factor, beta-catenin and the like in the hair growth process, prevent hair follicles from entering a resting period, and can also accelerate scalp metabolism, but when the content of the roselle extract is too high, the problems of scalp hair follicle blockage, dandruff, alopecia and the like are easily caused. Therefore, the application further controls the adding amount of the geranium extract and the roselle extract within the range, and the obtained hair-growing essence can accelerate scalp blood circulation, has proper stimulation effect on hair follicles, and has the best hair-growing effect on scalp.
Preferably, the bacteriostatic agent is selected from the group consisting of 1, 2-pentanediol, tea polyphenol, propyl paraben, and 1, 2-hexanediol.
Preferably, the bacteriostatic agent is a mixture of 1, 2-hexanediol and tea polyphenol; the weight ratio of the 1, 2-hexanediol to the tea polyphenol is 1: (2.5-4).
The application further selects the mixture of the 1, 2-hexanediol and the tea polyphenol as the bacteriostatic agent of the hair-growing essence, and controls the weight parts of the 1, 2-hexanediol and the tea polyphenol in the range, so that the obtained hair-growing essence can further inhibit bacteria on the surface layer of the scalp, promote the benign growth of hair follicle stem cells, stimulate the regeneration of hair follicles and improve the hair growth rate.
In some embodiments, the weight ratio of 1, 2-hexanediol to tea polyphenol may be 1: (1-2.5), 1: (1-3.5), 1: (1-4), 1: (2.5-3.5) or 1: (3.5-4).
In a specific embodiment, the weight ratio of 1, 2-hexanediol to tea polyphenol may also be 1: 1. 1:2.5, 1:3.5, 1:4.
preferably, the plant extract accounts for 5-7% of the total weight of the hair tonic.
Preferably, the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair-growing essence.
When the addition amount of the bacteriostatic agent is too small, the environment of hair follicles of the scalp is difficult to be improved, and hair growth is difficult; when the amount of the bacteriostatic agent added is too large, the growth rate of hair is affected. Therefore, the hair-growing essence obtained by controlling the addition amount of the bacteriostatic agent within the range has better effect on the growth rate of hair and hair follicle transformation.
Preferably, the hair growth essence further comprises a moisturizing agent, a preservative and a solvent.
Preferably, the humectant accounts for 0.8-2.3% of the total weight of the hair growth essence; the preservative accounts for 0.2 to 0.7 percent of the total weight of the hair-growing essence.
Preferably, the humectant is selected from butylene glycol, propylene glycol, PEG-7 glyceryl cocoate, methyl glucitol polyether; the antiseptic is selected from phenoxyethanol and ethylhexyl glycerol.
In a specific embodiment, the humectant is butanediol, and the preservative is phenoxyethanol and ethylhexyl glycerol in a mass ratio of 1.
Preferably, the solvent is selected from water, ethanol.
Preferably, the solvent is a mixture of water and ethanol; the volume ratio of the water to the ethanol is 1: (2.4-3.3).
In a specific embodiment, the volume ratio of the water to the ethanol is 1:3.
in a second aspect, the present application provides a method of preparing a hair growth essence.
A method for preparing a hair-growing essence comprises the following steps:
dissolving the bacteriostatic agent, the humectant and the preservative in a solvent, and heating the system to 75-85 ℃; adding the plant extracts into the system at an interval of 3-10min, wherein the geranium extract and the roselle extract are added at last; after the addition is finished, cooling the system to 40-50 ℃, and stirring for 0.5-1h at the temperature; finally, cooling to normal temperature to obtain the hair-growing essence.
According to the preparation method of the hair-growing essence liquid, the plant extracts are sequentially added, the adding time interval of the two plant extracts is controlled to be 3-10min, and the geranium extract and the roselle extract are finally added, so that the effect weakening caused by long-time stirring of the geranium extract and the roselle extract can be avoided, the optimal synergistic effect can be achieved among the plant extracts, and the hair-growing effect of the hair-growing essence liquid is better.
In summary, the present application has the following beneficial effects:
(1) The hair growth essence is prepared from plant extracts such as a geranium extract, a roselle extract and the like, and can stimulate hair follicle tissues, promote the transformation of hair follicles from a resting period to a growing period, improve scalp environment, accelerate scalp blood circulation and metabolism and further promote hair growth.
(2) The present application further controls the parts by weight of the components of the plant extract in the hair-growth essence to be within the following ranges: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract, and the obtained hair growth essence can further promote the transformation of hair follicles from a resting period to a growing period, effectively activate hair follicle tissues and further promote hair growth.
(3) The application adopts a mixture of 1, 2-hexanediol and tea polyphenol as a bacteriostatic agent, and the weight parts of the 1, 2-hexanediol and the tea polyphenol are controlled to be 1: (2.5-4), the hair follicle environment of the scalp can be further improved, the hair follicles can be promoted to be converted to the anagen phase, and the growth of the hairs can be accelerated.
Detailed Description
The application provides a hair-growing essence which comprises a plant extract, a bacteriostatic agent, a humectant, a preservative and a solvent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract. Further, the plant extract can also comprise the following components in parts by weight: 1.4-2.1 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract. Still further, the plant extract can also comprise the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
Wherein the bacteriostatic agent is selected from 1, 2-pentanediol, tea polyphenols, propyl p-hydroxybenzoate and 1, 2-hexanediol; further, the bacteriostatic agent is prepared from the following components in a weight ratio of 1: (2.5-4) a mixture of 1, 2-hexanediol and tea polyphenols. The humectant is selected from butanediol, propylene glycol, PEG-7 glyceryl cocoate, and methyl glucitol polyether; the antiseptic is selected from phenoxyethanol and ethylhexyl glycerol.
In the hair-growing essence provided by the application, the plant extract accounts for 5-7% of the total weight of the hair-growing essence, and the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair-growing essence. The humectant accounts for 0.8 to 2.3 percent of the total weight of the hair-growing essence; the preservative accounts for 0.2 to 0.7 percent of the total weight of the hair-growing essence.
The preparation method of the hair-growing essence comprises the following steps:
dissolving a bacteriostatic agent, a humectant and a preservative in a volume ratio of 1: (2.4-3.3) in water and ethanol, and heating the system to 75-85 ℃; sequentially adding folium Platycladi extract, delphinium veronicum extract, mori fructus extract, folium Pini extract, radix et caulis Opuntiae Dillenii extract, radix moutan extract, herba Erodii seu Geranii extract and flos Hibisci Sabdariffae extract into the system, wherein the addition time interval of each two plant extracts is 3-10min; after the addition is finished, cooling the system to 40-50 ℃, and stirring for 0.5-1h at the temperature; finally, cooling to normal temperature to obtain the hair-growing essence.
In the application, the pine needle extract and the cactus extract are purchased from western safe Olympic Biotechnology Limited; geranium extract was purchased from Seisan Hippocasti Biotech limited; the mulberry extract and the cacumen biotae extract are obtained from Xian Tian Guangyuan biological technology limited; the peony root extract was purchased from Ningxia Vanilla biotech Inc.; roselle extract, delphinium extract, pine needle extract, and Opuntia ficus-indica extract (Opuntia ficus-indica extract) were obtained from Sierra bioengineering, inc.; CAS number of tea polyphenols is 84650-60-2, purity is 98%; CAS number for 1, 2-pentanediol is 5343-92-0;1, 2-hexanediol has a CAS number of 6920-22-5; the remaining raw materials, solvents, etc. are commercially available.
The present application will be described in further detail below with reference to examples, comparative examples and performance testing tests.
Examples
Examples 1 to 8
Examples 1 to 8 each provide a hair growth essence.
The above embodiments differ in that: the amounts of the components in the plant extract are shown in table 1.
The preparation method of the hair-growing essence provided in embodiment 2 specifically includes the following steps:
(1) Weighing the plant extracts according to the addition amount of table 1: 1.4g of geranium extract, 0.8g of roselle extract, 0.75g of cacumen biotae extract, 0.5g of delphinium extract, 0.85g of mulberry extract, 0.5g of pine needle extract, 0.4g of cactus extract and 0.4g of peony root extract.
(2) Dissolving 1.1g of bacteriostatic agent (1, 2-pentanediol), 1.7g of humectant (butanediol) and 0.5g of preservative (phenoxyethanol and ethylhexyl glycerol with the mass ratio of 1:3 in water and ethanol, and heating the system to 80 ℃; sequentially adding folium Platycladi extract, delphinium grandiflorum extract, mori fructus extract, folium Pini extract, radix et caulis Opuntiae Dillenii extract, radix moutan extract, herba Erodii seu Geranii extract and flos Hibisci Sabdariffae extract into the system, wherein the addition time interval of each two plant extracts is 5min; after the addition, the system is cooled to 45 ℃, and is stirred for 0.5h at the temperature; finally cooling to normal temperature to obtain the hair-growing essence.
TABLE 1 addition amount of plant extract fraction component in hair growth essence provided in examples 1-8
Example 9
Example 9 was carried out as in example 2, except that: the bacteriostatic agent used in example 9 was 1, 2-hexanediol.
Example 10
Example 10 was carried out as in example 2, except that: the bacteriostatic agent used in example 10 was tea polyphenol.
Examples 11 to 14
Examples 11 to 14 each provide a hair tonic.
Examples 11-14 were carried out as in example 2, except that: the bacteriostatic agent in the hair-growing essence is a mixture of 1, 2-hexanediol and tea polyphenol, and the weight ratio of the 1, 2-hexanediol to the tea polyphenol is shown in Table 2.
TABLE 2 weight ratios of bacteriostatic components in examples 11-14
Example 15
Example 15 was carried out as in example 2, except that: the bacteriostatic agent adopted in the embodiment 15 is prepared from the following components in percentage by weight of 1:3.5 of 1, 2-pentanediol and tea polyphenols.
Example 16
Example 16 was carried out as in example 12, except that: in example 16, the amount of the bacteriostatic agent added was 0.5g.
Example 17
Example 17 was carried out as in example 12, except that: in example 17, the amount of the bacteriostatic agent added was 1.8g.
Example 18
Example 18 was carried out as in example 12, except that: in example 18, the amount of the bacteriostatic agent added was 2.5g.
Comparative example
Comparative example 1
Comparative example 1 was carried out as in example 2, except that: the hair growth essence provided in comparative example 1 was not added with a bacteriostatic agent.
Comparative example 2
Comparative example 2 was carried out as in example 2, except that: the plant extract of comparative example 2 was not added with geranium extract.
Comparative example 3
Comparative example 3 was carried out as in example 2, except that: the roselle extract was not added to the plant extract of comparative example 3.
Comparative example 4
Comparative example 4 was carried out as in example 2, except that: the geranium extract in example 2 was replaced with a polygonum multiflorum extract and the roselle extract with a ginseng root extract.
Comparative example 5
Comparative example 5 was carried out as in example 2, except that: the geranium extract in example 2 was replaced with a longhairy antenoron herb extract (from western safe ao biotechnology limited) and the roselle extract was replaced with a balsamine extract (from western safe ao biotechnology limited).
Comparative example 6
Comparative example 6 was carried out as in example 2, except that: the addition amount of each plant extract in comparative example 6 was: 0.6g of geranium extract, 0.8g of roselle extract, 0.3g of cacumen biotae extract, 0.5g of delphinium extract, 1.5g of mulberry extract, 0.8g of pine needle extract, 0.6g of cactus extract and 0.2g of peony root extract.
Comparative example 7
Comparative example 7 was carried out as in example 2, except that: the addition amount of each plant extract in comparative example 7 was: 2.4g of geranium extract, 0.2g of roselle extract, 0.75g of cacumen biotae extract, 0.5g of delphinium extract, 0.25g of mulberry extract, 1.3g of pine needle extract, 1.1g of cactus extract and 0.4g of peony root extract.
Comparative example 8
The preparation method of the hair-growing essence comprises the following steps:
(1) The plant extracts were weighed according to the addition of example 2 in table 1: 1.4g of geranium extract, 0.8g of roselle extract, 0.75g of cacumen biotae extract, 0.5g of delphinium extract, 0.85g of mulberry extract, 0.5g of pine needle extract, 0.4g of cactus extract and 0.4g of peony root extract.
(2) Dissolving 1.1g of bacteriostatic agent (1, 2-pentanediol), 1.7g of butanediol and 0.5g of preservative (phenoxyethanol and ethylhexylglycerin with the mass ratio of 1:3 in water and ethanol, and heating the system to 80 ℃; then adding the mixture of the plant extracts into the system at one time; after the addition is finished, the system is cooled to 45 ℃, and is stirred for 0.5 to 1 hour at the temperature; finally, cooling to normal temperature to obtain the hair-growing essence.
Performance test
Mouse experiment
The results of the hair growth effect of the hair growth essence provided in examples 1 to 18 and comparative examples 1 to 8 of the present application were examined by mouse tests, and the experimental procedures were as follows:
(1) Test subjects: 81C 57BL/6 mice, randomly divided into 27 groups, each group of 3.
(2) The test method comprises the following steps: taking the parallel spines of the mice as the long axis direction, cutting the back hairs of all the mice short, then smearing the depilatory, and then wiping off the depilatory, wherein the skin on the backs of the depilated mice has pink color, smooth surfaces, no bruising and no melanin pigmentation; the next day, a 2-2cm area was selected on the back of the mouse as the area to be tested, the hair growth essence was applied to the back of the mouse with a cotton swab, and the mouse was cleaned with physiological saline after being applied for 10 min. Wherein, each of the 26 groups is coated with a hair growth essence provided by the examples and the comparative examples, and the test groups 1-26,1 are respectively coated with normal saline as a control group; the coating is carried out once a day in a timed manner according to the above coating mode for 28 days continuously.
(3) Detection indexes are as follows:
(1) observing and recording the color change of the skin of the mice every day, taking pictures under the same light source, recording the basic physiological characteristics and the color change of the skin of the tested area on the back of each group of mice, and recording the time T for changing the color of the skin of the tested area from pink (resting period) to black (growing period) 1 And the time T required to change from black (growth phase) to grey (regression phase) 2 。
(2) On day 28, 10 random new hairs were collected from the test area on the back of the mouse, and the length l was measured using a digital display vernier caliper and recorded.
(3) On the 28 th day, the skin area of the test area on the back of the mouse is about 2cm × 2cm, and the mouse is subjected to conventional tissue dehydration, paraffin embedding, sectioning, HE staining (hematoxylin-eosin staining), observed under a × 100 microscope, and counted to obtain the total number of hair follicles in the hair follicle cross section of the mouse.
(3) And (3) test results: the results of the hair growth test in the 27 groups of mice are shown in table 3 below: (the following data are taken as the mean of the results of the tests in each group of mice).
TABLE 3 Hair growth in 27 groups of mice
According to the test results of the test groups 1-18 and the control group, the control group smears the back of the mouse by using normal saline, the number of hair follicles on the back of the mouse is only about 39 on day 28, and the hair length is only about 4.26 cm; and adopt the hair restorer that this application provided to paint mouse back, mouse back can grow hair fast to the hair length of mouse's back reaches more than 55cm on day 28, and the hair follicle number reaches more than 60. Therefore, the hair growth essence provided by the application can activate hair follicle tissues, promote the transformation of hair follicles from a resting period to a growing period, promote hair growth and achieve the effect of hair growth.
According to the test results of the test groups 1-8 and 19-25, the hair growth essence which can stimulate hair follicle tissues and promote hair to grow rapidly is prepared by mixing plant extract mixtures such as geranium extract, roselle extract and the like with bacteriostatic agents in the embodiments 1-8 of the application; when one or both of the geranium extract and the roselle extract were not added in comparative examples 2 to 5, the obtained hair tonic did not improve hair follicle tissue of scalp. Further experimental investigation revealed that the hair growth-promoting effects and the hair follicle-improving effects of the hair growth-promoting essences obtained in examples 1 to 8 were significantly superior to those of the hair growth-promoting essences obtained in comparative examples 6 to 7, indicating that the present application controlled the amount of each plant extract to be added within the following ranges: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract, and the obtained hair growth essence can accelerate the growth rate of hair, can also promote the transformation of hair follicles from a resting stage to a growing stage, effectively activate hair follicle tissues and promote the growth of hair.
According to the test results of the test groups 2 and 9-15, the hair growth rate, the hair length and the hair follicle number of the mice in the test groups 11-15 are obviously superior to those of the mice in the test groups 2 and 9-10, which shows that the hair growth effect of the hair growth essence prepared by using the bacteriostatic agent prepared from any two of 1, 2-hexanediol, 1, 2-pentanediol and tea polyphenol is superior to that of the hair growth essence prepared by only using one bacteriostatic agent. Further comparison shows that the skin of the mice in the test groups 11-14 changes from pink to black within 5-6 days, the skin of the mice changes from black to gray within 12-13 days, and the number of hair follicles reaches more than 67, which indicates that the hair growth essence adopts the mixture of 1, 2-hexanediol and tea polyphenol as a bacteriostatic agent, can further improve the environment of the hair follicles in the scalp, promote the hair follicles to transform to the growth phase and further accelerate the growth of the hairs.
According to the detection results of the test groups 12 and 16-18, the hair length of the hair of the mouse in the examples 2 and 17 at the 28 th day is more than 8cm, and the number of hair follicles is more than or equal to 68; the hair length of the hair of the 16 mice in the test group at the 28 th day is about 7.36cm, and the number of hair follicles is 63-64; the hair length of the hair of the test group 18 mice on day 28 was about 6.92cm, and the number of hair follicles was 66 to 67. Therefore, the hair growth effect and the hair follicle transformation effect of the obtained hair growth essence are better when the addition amount of the bacteriostatic agent is controlled within the range of 1.1-1.8%.
According to the results of the tests of test group 2 and test group 26, it was found that the skin color change time of the mice of test group 26 was long after using the hair growth essence provided in comparative example 8, and the hair length on day 28 was only about 5.16cm, and the number of hair follicles on day 28 was only about 52, indicating that the hair growth essence obtained by the method for preparing the hair growth essence provided in comparative example 8 was not excellent in the use effect. Therefore, the components of the plant extract are sequentially added, and the adding interval time of the two adjacent components of the plant extract is controlled to be 3-10min, so that the effect weakening caused by long-time stirring of part of the extract can be avoided, the optimal synergistic effect among the plant extracts can be realized, and the hair growth effect of the hair growth essence is better.
Hair growth effect test
The hair growth effect and the comfort level of the hair growth essence provided in example 17 of the present application were tested, and the results are shown in table 4.
(1) Searching 30 volunteers, smearing the hair growth essence provided in the application example 17 on 10 volunteers, and setting as group A, smearing commercially available hair growth essence (main components including Polygoni Multiflori radix, fructus Ligustri Lucidi, radix Angelicae sinensis, ginseng radix, rhizoma Ligustici Chuanxiong, rhizoma Zingiberis recens, and folium Platycladi) on 10 volunteers, and setting as group B; no hair growth promoting solution was used in 10 volunteers, control group.
(2) Example 17 hair growth essence was used by the following method: applying hair growth essence on hair root, and lightly massaging scalp with fingertip for 10min; the medicine is used once every 2 days, and the dosage is 2mL each time; the commercial hair restorer is used according to the instruction.
(3) The test period is 4 months, and the using comfort level (whether the scalp has discomfort, such as stickiness and pruritus) of the hair essence of each volunteer is recorded in the experimental using process; and the hair growth conditions of the volunteers before, 1 month, 2 months and 3 months of use are photographed by a miniature camera to evaluate the hair density.
Table 4 test results of hair growth effect and comfort in use of volunteers
According to the test results of the hair growth effect and the comfort level, the hair growth essence provided by the embodiment 17 of the present application has an excellent hair growth effect, and can increase the hair by 24.8% within 4 months, and the comparison of the experimental data of the group a and the group B shows that the hair growth effect of the hair growth essence of the present application is slightly superior to that of the hair growth liquid on the market.
In conclusion, the hair growth essence provided by the application can stimulate hair follicle tissues, promotes the hair follicles to be converted from a resting period to a growing period, and can also improve scalp environment, accelerate scalp blood circulation and further promote hair growth.
The invention has been described in detail with respect to a general description and specific embodiments thereof, but it will be apparent to those skilled in the art that modifications and improvements can be made based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A hair-growing essence, which is characterized by comprising a plant extract and a bacteriostatic agent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
2. The hair growth essence according to claim 1, wherein the plant extract comprises the following components in parts by weight: 1.4-2.1 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
3. The hair growth essence according to claim 1, wherein the plant extract comprises the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
4. The hair growth shampoo of claim 1 wherein the bacteriostatic agent is selected from the group consisting of 1, 2-pentanediol, tea polyphenol, propyl paraben, and 1, 2-hexanediol.
5. The hair growth essence according to claim 1, wherein the bacteriostatic agent is a mixture of 1, 2-hexanediol and tea polyphenols; the weight ratio of the 1, 2-hexanediol to the tea polyphenol is 1: (2.5-4).
6. The hair growth essence according to claim 1, wherein the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair growth essence.
7. The hair growth essence according to any one of claims 1 to 6, further comprising a humectant, a preservative and a solvent.
8. The hair growth essence according to claim 7, wherein the moisturizer comprises 0.8 to 2.3% by weight of the total hair growth essence; the preservative accounts for 0.2 to 0.7 percent of the total weight of the hair-growing essence.
9. The hair growth essence according to claim 7,
the humectant is selected from butanediol, propylene glycol, PEG-7 glycerol cocoate, and methyl glucitol polyether;
the antiseptic is selected from phenoxyethanol and ethylhexyl glycerol.
10. A process for the preparation of a hair growth essence according to any one of claims 7 to 9 comprising the steps of:
dissolving the bacteriostatic agent, the humectant and the preservative in a solvent, and heating the system to 75-85 ℃; adding the plant extracts into the system at an interval of 3-10min, wherein the geranium extract and the roselle extract are added at last; after the addition is finished, the temperature of the system is reduced to 40-50 ℃, and the system is stirred for 0.5-1h at the temperature; finally cooling to normal temperature to obtain the hair-growing essence.
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