CN113171329A - Plant multi-effect anti-hair loss hair-growing hair-nourishing compound composition and preparation method thereof - Google Patents

Abstract

The invention discloses a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which consists of a solvent and compound plant components; the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol; the compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

Description

Plant multi-effect anti-hair loss hair-growing hair-nourishing compound composition and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a plant multi-effect anti-hair loss hair-growing hair-nourishing compound composition and a preparation method thereof.

Background

Alopecia is the phenomenon of hair loss, normally lost hairs are all hairs in the catagen and telogen periods, and as hairs in the catagen and newly growing periods are constantly in dynamic balance, normal amount of hairs can be maintained. However, with the increasing social pressure and the increasing pace of life, the environment deteriorates continuously, and the eating habits of poor diet, more and more alopecia patients are in China.

Problems with living hair typically include: alopecia caused by seborrheic dermatitis; endocrine alopecia such as female postpartum alopecia and climacteric alopecia; alopecia caused by nutritional metabolism such as weight loss, vitamin deficiency, malnutrition, etc.; pathological alopecia caused by radiotherapy, chemotherapy and folliculitis; hair loss caused by chemical stimulation such as perm, hair dyeing and the like due to improper selection of washing and caring products; the hair is thin, withered and yellow, thin, soft, easy to break and unhealthy due to greater mental stress. These problems of hair loss not only affect the appearance of the instrument, but also cause great impact on the confidence of the person. The human hair follicle is a target organ sensitive to androgen, the androgen secreted by the human body is mainly testosterone, the testosterone is converted into dihydrotestosterone under the action of 5-alpha reductase, and then the dihydrotestosterone is combined with androgen receptors in hair follicle target cells on the scalp to inhibit the growth and development of hair papilla and interfere the growth and metabolism of hair follicle cells, so that the hair enters a resting period in advance, and thus alopecia is caused. In addition, the hair follicles are more sensitive to androgens in some people due to genetic factors, and can also cause hair loss at normal androgen levels.

In order to improve hair loss and promote hair growth, there are methods for nourishing hair follicles by externally applying active proteins in the prior art, but the effect is not significant. The hair follicle nutrient solution on the market is good and uneven, the adverse reaction is frequent, the safety problem is prominent, and the incidence rate of irritative reaction, allergic reaction and phototoxicity reaction is high, so that a specific hair follicle nutrient solution composition is needed to be arranged, the curative effect is definite, the hair growth can be promoted, the hair follicle nutrient solution composition is fast and safe, the negative effect is not generated, and the trouble of patients with the problems of the hair can be practically relieved.

Disclosure of Invention

The invention aims to solve the technical problems and provides a plant multi-effect anti-hair loss hair-growing hair-nourishing compound composition and a preparation method thereof.

In order to solve the problems, the invention is realized according to the following technical scheme:

in a first aspect, the invention provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which consists of a solvent and compound plant components;

the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol;

the compound plant components comprise the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

In combination with the first aspect, the present invention also provides the 1 st embodiment of the first aspect, wherein the compound plant component consists of the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract, dictamnus root bark extract, swertia japonica extract, sergeant serpens fruit extract, raspberry extract and phaeodactylum tricornutum extract.

With reference to the first aspect, the present invention further provides a 2 nd embodiment of the first aspect, wherein the compound plant component is composed of the following raw materials in parts by weight:

2-10 parts of cacumen biotae extract, 4-7 parts of eclipta prostrata extract, 3-6 parts of polygonum multiflorum root extract, 1-5 parts of ligusticum wallichii root extract, 1-2 parts of ginseng root extract, 1-4 parts of sophora flavescens root extract, 1-3 parts of angelica sinensis root extract, 1-3 parts of rehmannia root extract, 2-5 parts of radix paeoniae rubra extract, 3-6 parts of magnolia bark extract, 1-2 parts of glossy privet fruit extract, 1-2 parts of gleditsia sinensis extract, 5-10 parts of camellia seed extract, 1-4 parts of pseudo-ginseng root extract, 1-2 parts of cortex dictamni extract, 1-3 parts of swertia extract, 1-4 parts of saw palmetto fruit extract, 2-5 parts of raspberry extract and 2-6 parts of phaeodactylum algae extract.

With reference to the first aspect, the present invention further provides a 3 rd embodiment of the first aspect, wherein the compound plant component is composed of the following raw materials in parts by weight:

6 parts of cacumen biotae extract, 5 parts of eclipta prostrata extract, 4 parts of polygonum multiflorum root extract, 3 parts of ligusticum wallichii root extract, 2 parts of ginseng root extract, 3 parts of sophora flavescens root extract, 2 parts of angelica sinensis root extract, 2 parts of rehmannia root extract, 3 parts of radix paeoniae rubra root extract, 5 parts of magnolia bark extract, 2 parts of glossy privet fruit extract, 2 parts of gleditsia sinensis extract, 7 parts of camellia seed extract, 3 parts of pseudo-ginseng root extract, 2 parts of cortex dictamni extract, 2 parts of swertia extract, 3 parts of saw palmetto fruit extract, 4 parts of raspberry extract and 4 parts of phaeodactylum tricornutum extract.

With reference to the first aspect, the present invention further provides a 4 th embodiment of the first aspect, wherein the compound plant component accounts for 8-12% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair care compound composition by weight.

In combination with the first aspect, the invention also provides a 5 th embodiment of the first aspect, wherein the compound plant components account for 10% of the total amount of the plant pleiotropic alopecia preventing, hair growing and hair nourishing compound composition in weight ratio.

In a second aspect, the invention also provides a preparation method of the plant pleiotropic alopecia preventing, hair growing and hair nourishing compound composition described in the 1 st to 5 th aspects of the first aspect, wherein the preparation method comprises the following steps:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 40-60 ℃, and fully stirring to obtain a mixed solution;

(2) adding the compound plant extract into the mixed solution, fully stirring for 10min, and cooling to obtain the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition;

wherein the compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

In a third aspect, the invention also provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which consists of a solvent and compound plant components;

the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol;

the compound plant component comprises the following raw materials in parts by weight:

2-10 parts of cacumen biotae extract, 4-7 parts of eclipta prostrata extract, 3-6 parts of polygonum multiflorum root extract, 1-5 parts of ligusticum wallichii root extract, 1-2 parts of ginseng root extract, 1-4 parts of sophora flavescens root extract, 1-3 parts of angelica sinensis root extract, 1-3 parts of rehmannia root extract, 2-5 parts of radix paeoniae rubra extract, 3-6 parts of magnolia bark extract, 1-2 parts of glossy privet fruit extract, 1-2 parts of gleditsia sinensis extract, 5-10 parts of camellia seed extract, 1-4 parts of pseudo-ginseng root extract, 1-2 parts of cortex dictamni extract, 1-3 parts of swertia extract, 1-4 parts of saw palmetto fruit extract, 2-5 parts of raspberry extract and 2-6 parts of phaeodactylum algae extract.

Compared with the prior art, the invention has the beneficial effects that:

(1) the invention provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which only consists of a solvent and compound plant components, has no chemical additive and the like, is safe to use and does not generate irritant negative effects; has definite curative effect, can effectively prevent alopecia, nourish hair, promote hair growth and practically help the patients with hair problems to relieve troubles.

(2) The compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract. Through the mutual synergistic effect of the components of various plant extracts, the blood circulation of the head can be changed, the hair follicle can be activated, the hair can be prevented from falling off and repaired, and the effect of treating both symptoms and root causes can be achieved.

(3) The compound plant components of the invention can change the blood circulation of the head, activate hair follicles and realize the hair restoration effect by the mutual synergistic effect of the active components in the Chinese arborvitae leaves and the active components in the polygonum multiflorum, the eclipta alba, the angelica and the like, and the active components of various plant extracts.

(4) The invention provides a pure plant extract formula capable of effectively promoting hair follicle growth and inhibiting bacteria, which is obtained by limiting the selection and content of effective components in a plant component formula, and the formula does not adopt the treatment effect which is achieved by the superposition of single drug effects of more than ten traditional Chinese medicines after the compatibility of the traditional Chinese medicines in the prior art, but is verified by repeated tests, and the effective components are reasonably played under the compatibility of the traditional Chinese medicines by selecting a specific traditional Chinese medicine formula, so that the anti-hair loss and hair growth effect of treatment is synergistically achieved.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is obvious that the embodiments described are only some representative embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

Introduction to Compound compositions

The invention provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which consists of a solvent and compound plant components. Wherein the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol;

the compound plant components comprise the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

Preferably, in the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, the compound plant components consist of the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract, dictamnus root bark extract, swertia japonica extract, sergeant serpens fruit extract, raspberry extract and phaeodactylum tricornutum extract.

Specifically, in a preferred embodiment, the present invention provides the following preferred raw material proportioning examples:

the compound plant component accounts for 8-12% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight. The compound plant component comprises the following raw materials in parts by weight:

2-10 parts of cacumen biotae extract, 4-7 parts of eclipta prostrata extract, 3-6 parts of polygonum multiflorum root extract, 1-5 parts of ligusticum wallichii root extract, 1-2 parts of ginseng root extract, 1-4 parts of sophora flavescens root extract, 1-3 parts of angelica sinensis root extract, 1-3 parts of rehmannia root extract, 2-5 parts of radix paeoniae rubra extract, 3-6 parts of magnolia bark extract, 1-2 parts of glossy privet fruit extract, 1-2 parts of gleditsia sinensis extract, 5-10 parts of camellia seed extract, 1-4 parts of pseudo-ginseng root extract, 1-2 parts of cortex dictamni extract, 1-3 parts of swertia extract, 1-4 parts of saw palmetto fruit extract, 2-5 parts of raspberry extract and 2-6 parts of phaeodactylum algae extract.

The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition has the following effects:

(1) the invention provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which only consists of a solvent and compound plant components, has no chemical additive and the like, is safe to use and does not generate irritant negative effects; has definite curative effect, can effectively prevent alopecia, nourish hair, promote hair growth and practically help the patients with hair problems to relieve troubles.

(2) The compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract. Through the mutual synergistic effect of the components of various plant extracts, the blood circulation of the head can be changed, the hair follicle can be activated, the hair can be prevented from falling off and repaired, and the effect of treating both symptoms and root causes can be achieved.

(3) The compound plant components of the invention can change the blood circulation of the head, activate hair follicles and realize the hair restoration effect by the mutual synergistic effect of the active components in the Chinese arborvitae leaves and the active components in the polygonum multiflorum, the eclipta alba, the angelica and the like, and the active components of various plant extracts.

(4) The invention provides a pure plant extract formula capable of effectively promoting hair follicle growth and inhibiting bacteria, which is obtained by limiting the selection and content of effective components in a plant component formula, and the formula does not adopt the treatment effect which is achieved by the superposition of single drug effects of more than ten traditional Chinese medicines after the compatibility of the traditional Chinese medicines in the prior art, but is verified by repeated tests, and the effective components are reasonably played under the compatibility of the traditional Chinese medicines by selecting a specific traditional Chinese medicine formula, so that the anti-hair loss and hair growth effect of treatment is synergistically achieved.

As used herein, "synergy" or "synergistic effect" refers to an effect that occurs when chemical substances or biological structures interact and produce a total effect that is greater than the sum of the individual effects of any one of them.

The effective components of the cacumen biotae extract are mainly flavonoids, so that the cacumen biotae extract can activate hair mother cells, promote blood circulation and revive hair follicles with declined hair growth capacity, and also has the effects of inhibiting bacteria, resisting inflammation and regulating oil secretion; the main components of the extract of the sophora flavescens root used in the invention are alkaloid and flavonoid substances, and the extract has the functions of diminishing inflammation, resisting bacteria and resisting male hormone; the snakehead intestine extract mainly contains saponin and flavonoid substances as active ingredients, can activate melanocytes and enhance tyrosinase activity, and has the effects of blackening and blackening hair; the effective components of the angelica root extract mainly comprise polysaccharide substances, and the angelica root extract can expand scalp capillaries, promote blood circulation, nourish scalp, prevent scalp roughness, promote hair growth, promote tyrosinase to generate dopa and dopa to generate baoquinone, increase melanin generation, enhance tyrosinase activity and make hair black and bright; the glossy privet fruit extract used for the hair contains ursolic acid, salidroside and oleanolic acid, has flavonoid compounds, and can promote the generation of tyrosinase activity and promote melanin hyperplasia. The saw palmetto fruit extract mainly contains saw palmetto oil as the active ingredient, and contains saturated and unsaturated fatty acids such as oleic acid, linoleic acid and the like, can effectively inhibit the activity of 5 alpha-reductase, reduce the generation of dihydrotestosterone, and has obvious improvement effect on androgenetic alopecia. The rehmannia root extract used in the invention contains various amino acids such as the rehmannia root glycoside, the acteoside, the catalpol glycoside and the like. Has effects in promoting cholesterol generation, improving sebum composition, resisting oxidation, and absorbing and moistening moisture at low temperature, inhibiting oiliness, softening skin, caring skin, promoting cathepsin activity and skin metabolism, blackening hair, and promoting hair growth. The ligusticum wallichii plant extract can be used for specifically promoting the proliferation of human dermal papilla cells, increasing the number of hair follicle cells, increasing the growth length of hair follicles and increasing the growth length of hairs.

The research of the applicant shows that 8 specific plant extracts are compounded to obtain the Chinese arborvitae twig extract, the sophora flavescens root extract, the angelica root extract, the eclipta prostrata extract, the glossy privet fruit extract, the saw palmetto fruit extract, the rehmannia root extract and the ligusticum wallichii plant extract, and the 8 raw materials are mutually cooperated to activate hair follicles, promote melanin hyperplasia, diminish inflammation and resist bacteria and inhibit the activity of 5 alpha-reductase, so that the Chinese arborvitae twig extract has more excellent functions of preventing hair loss, growing hair and blackening hair compared with the existing products. Under the synergistic effect of the ligusticum wallichii plant extract, the hair growth effect is more remarkable by being cooperated with other components.

On the other hand, the compound plant component is obtained by compounding a plurality of Chinese herbal medicine extracts, all substances in the compound plant component are matched with each other to realize synergistic interaction, and extracts of raw materials such as cacumen biotae, polygonum multiflorum, camellia seeds, eclipta prostrata and the like effectively provide sufficient nutrition for the scalp, promote the blood circulation of the scalp, accelerate the metabolism of the scalp, improve the function of hair follicles and promote the regeneration of hairs. Promoting division and proliferation of hair mother cell, promoting hair follicle growth, and inhibiting 5 alpha-reductase. On the other hand, the composition can inhibit and kill fungi, improve scalp cell activity, regulate scalp cell metabolism, and improve scalp cell microenvironment.

On the other hand, the red peony extract has stronger anti-inflammatory effect and can have obvious inhibition effect on hyperfiltration, exudation and edema of capillary vessels and immune inflammation caused by various inflammatory agents. The composition is used in cooperation with a cacumen biotae extract, a magnolia bark extract and a gleditsia sinensis lam extract, has a better antibacterial and anti-inflammatory effect, and is more beneficial to healthy growth of hair. The gleditsia sinensis extract has natural inhibition and sterilization effects on a plurality of bacteria and fungi, can be used for external sterilization and can also be safely used as an internal sterilization medicine, and because the gleditsia sinensis contains a plurality of local stimulation and sterilization effects, the local stimulation effect of the gleditsia sinensis can greatly promote scalp blood circulation, and therefore, the gleditsia sinensis extract also has certain effects on the aspects of healthy hair growth and alopecia prevention.

The swertia extract mainly contains iridoid components, triterpenoid saponin, flavonoid compounds and the like, the iridoid components are main effective components in swertia, and other components such as swertiamarin and gentiopicroside are also contained, and the swertia extract has the function of proliferating fibroblast, has the function of activating skin and can be used for anti-aging cosmetics.

The Ginseng radix extract is extracted from root, stem and leaf of Panax ginseng C.A. Meyer of Araliaceae, and is rich in eighteen kinds of ginseng monomer saponin and other nutrients; because ginseng contains ginsenoside, the ginseng can promote blood circulation, increase nutrition supply of scalp, improve immunity and prevent scalp from being harmfully stimulated by external environment.

The Notoginseng radix extract is root of Notoginseng radix of Araliaceae; the notoginseng root extract contains various effective components such as saponin, sanchinin, flavone, volatile oil, amino acid, saccharide and the like, and the total saponin content is about 12 percent, which is a main active component; modern pharmacological research shows that the notoginseng root extract not only has good two-way pharmacological effects of stopping bleeding, promoting blood circulation to remove blood stasis, but also has obvious blood enriching effect, and can promote the division and growth of various blood cells such as red blood cells, white blood cells, blood platelets and the like in blood, increase the number of the blood cells and keep the normal level.

The research of the applicant shows that after the swertia extract is added into the compound plant components, the swertia extract cooperates with the cacumen biotae extract and the ligusticum wallichii plant extract, in a rat hair growth test, the swertia extract promotes the compound composition to have excellent hair growth promoting capacity, which is the effect of the effective component swertiamarin, and in addition, the swertia also contains active enzyme, which is an overall effect molecular group and can well inhibit the appearance and expression of a hair loss gene FGF-5 gene, so that the good alopecia preventing and growing effect is achieved.

The research of the applicant shows that after the phaeodactylum tricornutum extract is added into the compound plant components, the phaeodactylum tricornutum extract is cooperated with the swertia japonica extract, the cacumen biotae extract and the ligusticum wallichii plant extract, and in a rat hair growth test, the phaeodactylum tricornutum extract promotes the compound composition to have more excellent hair growth promoting capability. Under the specific mixture ratio of the invention, the phaeodactylum tricornutum extract has excellent functions of improving the growth activity of human hair papilla cells, human hair matrix systems and human hair follicle outer root sheath cells. When the part of the phaeodactylum tricornutum extract is reduced, the effect of the compound composition on improving the growth of hair follicles and hairs is obviously reduced, and when the part of the phaeodactylum tricornutum extract is larger in specific gravity, the improvement effect is inhibited.

Use of Compound compositions

The use method of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition comprises the following steps:

a, directly spraying a proper amount of plant multi-effect hair loss prevention, hair growth promotion and hair nourishing compound composition on the root of hair;

and step B, massaging the head by gently pointing the abdomen for 5-10 minutes to ensure that the scalp fully absorbs the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition.

Wherein the composition is used at least 3-5 times per week.

Introduction of compound composition technology

The invention also provides a preparation method for preparing the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which comprises the following steps:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 40-60 ℃, and fully stirring to obtain a mixed solution;

(2) and adding a compound plant extract into the mixed solution, wherein the compound plant component accounts for 8-12% of the total amount of the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition in percentage by weight. Fully stirring for 10min, and cooling to obtain the plant multi-effect anti-hair loss, hair growing and hair nourishing compound composition;

wherein the compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

Preparation examples

Example 1

The embodiment 1 provides a plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition, which consists of a solvent and compound plant components. The solvent is a mixed solution of water, butanediol and 1, 2-hexanediol; the compound plant component accounts for 8% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight.

The compound plant component comprises the following raw materials in parts by weight:

2 parts of cacumen biotae extract, 4 parts of eclipta prostrata extract, 3 parts of polygonum multiflorum root extract, 1 part of ligusticum wallichii root extract, 1 part of ginseng root extract, 1 part of sophora flavescens root extract, 1 part of angelica sinensis root extract, 1 part of rehmannia root extract, 2 parts of radix paeoniae rubra root extract, 3 parts of magnolia bark extract, 1 part of glossy privet fruit extract, 1 part of gleditsia sinensis extract, 5 parts of camellia seed extract, 1 part of pseudo-ginseng root extract, 1 part of cortex dictamni extract, 1 part of swertia extract, 1 part of saw palmetto fruit extract, 2 parts of raspberry extract and 2 parts of phaeodactylum tricornutum extract.

The embodiment 1 provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which is prepared by the following preparation method:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 40 ℃, and fully stirring to obtain a mixed solution;

(2) and adding the compound plant extract into the mixed solution, fully stirring for 10min, and cooling to obtain the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition.

Example 2

The embodiment 2 provides a plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition, which consists of a solvent and compound plant components. The solvent is a mixed solution of water, butanediol and 1, 2-hexanediol; the compound plant component accounts for 10% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight.

The compound plant component comprises the following raw materials in parts by weight:

6 parts of cacumen biotae extract, 5 parts of eclipta prostrata extract, 4 parts of polygonum multiflorum root extract, 3 parts of ligusticum wallichii root extract, 2 parts of ginseng root extract, 3 parts of sophora flavescens root extract, 2 parts of angelica sinensis root extract, 2 parts of rehmannia root extract, 3 parts of radix paeoniae rubra root extract, 5 parts of magnolia bark extract, 2 parts of glossy privet fruit extract, 2 parts of gleditsia sinensis extract, 7 parts of camellia seed extract, 3 parts of pseudo-ginseng root extract, 2 parts of cortex dictamni extract, 2 parts of swertia extract, 3 parts of saw palmetto fruit extract, 4 parts of raspberry extract and 4 parts of phaeodactylum tricornutum extract.

The embodiment 2 provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which is prepared by the following preparation method:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 50 ℃, and fully stirring to obtain a mixed solution;

(2) and adding the compound plant extract into the mixed solution, fully stirring for 10min, and cooling to obtain the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition.

Example 3

The embodiment 3 provides a plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition, which consists of a solvent and compound plant components. The solvent is a mixed solution of water, butanediol and 1, 2-hexanediol; the compound plant component accounts for 12% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight.

The compound plant component comprises the following raw materials in parts by weight:

10 parts of cacumen biotae extract, 7 parts of eclipta prostrata extract, 6 parts of polygonum multiflorum root extract, 5 parts of ligusticum wallichii root extract, 2 parts of ginseng root extract, 4 parts of sophora flavescens root extract, 3 parts of angelica sinensis root extract, 3 parts of rehmannia root extract, 5 parts of radix paeoniae rubra root extract, 6 parts of magnolia bark extract, 2 parts of glossy privet fruit extract, 2 parts of gleditsia sinensis extract, 10 parts of camellia seed extract, 4 parts of pseudo-ginseng root extract, 2 parts of cortex dictamni extract, 3 parts of swertia extract, 8 parts of eclipta alba extract, 4 parts of serenoa serrulata fruit extract, 5 parts of raspberry extract and 6 parts of phaeodactylum tricornutum extract.

The embodiment 3 provides a plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition, which is prepared by the following preparation method:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 60 ℃, and fully stirring to obtain a mixed solution;

(2) and adding the compound plant extract into the mixed solution, fully stirring for 10min, and cooling to obtain the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition.

Product testing

Test example 1

160 volunteers with frequent alopecia are screened by adopting a civil investigation and grading method (the age is between 20 and 60 years, the proportion of male and female is 1:1), the volunteers are randomly divided into three groups of 20 persons, and the plant multi-effect alopecia preventing and hair growing and nourishing compound composition prepared in the embodiment 1-2 and common alopecia preventing products on the market are respectively used. The anti-hair loss effect and the feeling of use were used as evaluation criteria: the plant multi-effect hair loss preventing, hair growing and nourishing compound composition is effective in reducing or stopping hair loss, and the hair loss is still or increased to be ineffective, so that the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition is compared with a common hair loss preventing product. The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition is used for at least 2-3 times per week, the using time is three months, and the total effect is observed after three months. See table 1.

TABLE 1 results of the falling prevention

The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition prepared by the invention can effectively prevent hair loss, has no abnormal feeling, no itching, tightness and no oil generation after use, mainly has the effects of inhibiting bacteria, diminishing inflammation, fixing hair and preventing hair loss due to pure plant extracts, and has obvious advantages compared with common products sold in the market.

Test example 2

(1) Materials:

animals: male rat, weight 18-20g

Test samples:

the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition prepared in the embodiment 2;

comparative example 1: removing swertia japonica Makino extract of example 2;

comparative example 2: removing Phaeodactylum tricornutum extract of example 2;

comparative example 3: removing swertia extract and phaeodactylum tricornutum extract in example 2;

comparative example 4: removing the cacumen Platycladi extract and rhizoma Ligustici Chuanxiong extract of example 2;

the test instrument: olympus microscope, electron microscope, single lens reflex camera

(2) The test method comprises the following steps:

1. preparing a model: 150 mg-kg-1 cyclophosphamide is injected into a rat depilatory area once and subcutaneously to establish a rat depilatory model.

2. Spraying the pesticide in groups: rats were divided into 5 groups according to the random number table: the groups of examples, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 were 10 in each group. The same dose of test sample was evenly sprayed onto the depilated area of rats in each test group 3 times per week for 6 consecutive weeks.

3. The hair growth condition of the unhairing zone of each group of rats is observed by naked eyes 1 day before and 1 and 6 weeks after the spraying, and images are collected and stored for later use by a Canon single lens reflex camera.

4. HE staining was performed to observe the morphological and number changes of hair follicles, 2 rats were randomly selected from each group to be sacrificed 1, 3 and 6 weeks after drug spraying, and skin tissues of the depilated area were taken. 5 high power fields (× 400) were selected for follicle counting and averaged. Results are expressed as x ± s and data were analyzed using SPSS17.0 statistical software.

Thirdly, test results:

before spraying, no hair grows in the hair-removing area of each group of rats and the hair is gray. After spraying for 1 week, the local skin of the depilating area of the rat is gradually changed from pink to grey black, the grey black area of the skin of the depilating area of the rat in the example group is obviously increased, and the grey black area of the skin of the depilating area of the comparative example 1 group and the skin of the depilating area of the comparative example 2 group are slightly increased; while the gray black area of the comparative example 3 group and the comparative example 4 group varied little and no significant difference was observed. After 6 weeks of spraying, the depilated area of each group of rats appeared black and more hair had gradually grown and elongated. The hair growth of the example group was denser than that of the comparative example 1 and comparative example 2 groups; while the densification degree was not significant in the comparative example 3 group and the comparative example 4 group.

2. Effect of the number of Hair follicles in the depilated region of depilated rats

The results are shown in Table 2 below, and the number of hair follicles was gradually decreased in each group of rats after depilation. At each time point, the number of follicles in the example group was significantly increased; while the comparative example 1 group and the comparative example 2 group were slightly increased; the increase was not significant for the comparative example 3 group.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims (8)

1. A plant multi-effect compound composition for preventing hair loss, growing hair and nourishing hair is characterized by comprising a solvent and compound plant components;

the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol;

the compound plant components comprise the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

2. The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition as claimed in claim 1, wherein the compound plant components consist of the following raw materials:

biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract, dictamnus root bark extract, swertia japonica extract, sergeant serpens fruit extract, raspberry extract and phaeodactylum tricornutum extract.

3. The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition as claimed in claim 2, wherein the compound plant components comprise the following raw materials in parts by weight:

2-10 parts of cacumen biotae extract, 4-7 parts of eclipta prostrata extract, 3-6 parts of polygonum multiflorum root extract, 1-5 parts of ligusticum wallichii root extract, 1-2 parts of ginseng root extract, 1-4 parts of sophora flavescens root extract, 1-3 parts of angelica sinensis root extract, 1-3 parts of rehmannia root extract, 2-5 parts of radix paeoniae rubra extract, 3-6 parts of magnolia bark extract, 1-2 parts of glossy privet fruit extract, 1-2 parts of gleditsia sinensis extract, 5-10 parts of camellia seed extract, 1-4 parts of pseudo-ginseng root extract, 1-2 parts of cortex dictamni extract, 1-3 parts of swertia extract, 1-4 parts of saw palmetto fruit extract, 2-5 parts of raspberry extract and 2-6 parts of phaeodactylum algae extract.

4. The plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition as claimed in claim 3, wherein the compound plant components comprise the following raw materials in parts by weight:

6 parts of cacumen biotae extract, 5 parts of eclipta prostrata extract, 4 parts of polygonum multiflorum root extract, 3 parts of ligusticum wallichii root extract, 2 parts of ginseng root extract, 3 parts of sophora flavescens root extract, 2 parts of angelica sinensis root extract, 2 parts of rehmannia root extract, 3 parts of radix paeoniae rubra root extract, 5 parts of magnolia bark extract, 2 parts of glossy privet fruit extract, 2 parts of gleditsia sinensis extract, 7 parts of camellia seed extract, 3 parts of pseudo-ginseng root extract, 2 parts of cortex dictamni extract, 2 parts of swertia extract, 3 parts of saw palmetto fruit extract, 4 parts of raspberry extract and 4 parts of phaeodactylum tricornutum extract.

5. The plant multi-effect anti-hair loss, hair growing and hair nourishing compound composition as claimed in claim 2, is characterized in that:

the compound plant component accounts for 8-12% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight.

6. The plant multi-effect anti-hair loss, hair growing and hair nourishing compound composition according to claim 5, which is characterized in that:

the compound plant component accounts for 10% of the total amount of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition in percentage by weight.

7. The preparation method of the plant multi-effect anti-hair loss, hair growth and hair nourishing compound composition according to any one of claims 1 to 6, characterized by comprising the following steps:

(1) adding a proper amount of water, butanediol and 1, 2-hexanediol into a container, heating to 40-60 ℃, and fully stirring to obtain a mixed solution;

(2) adding the compound plant extract into the mixed solution, fully stirring for 10min, and cooling to obtain the plant multi-effect hair loss preventing, hair growing and hair nourishing compound composition;

wherein the compound plant components comprise the following raw materials: biota orientalis leaf extract, eclipta prostrata extract, polygonum multiflorum root extract, ligusticum wallichii root extract, ginseng root extract, sophora flavescens root extract, angelica sinensis root extract, rehmannia glutinosa root extract, red peony root extract, magnolia bark extract, glossy privet fruit extract, gleditsia sinensis shell extract, camellia seed extract, pseudo-ginseng root extract and dictamnus dasycarpus root bark extract.

8. A plant multi-effect compound composition for preventing hair loss, growing hair and nourishing hair is characterized by comprising a solvent and compound plant components;

the solvent is a mixed solution of water, butanediol and 1, 2-hexanediol;

the compound plant component comprises the following raw materials in parts by weight:

2-10 parts of cacumen biotae extract, 4-7 parts of eclipta prostrata extract, 3-6 parts of polygonum multiflorum root extract, 1-5 parts of ligusticum wallichii root extract, 1-2 parts of ginseng root extract, 1-4 parts of sophora flavescens root extract, 1-3 parts of angelica sinensis root extract, 1-3 parts of rehmannia root extract, 2-5 parts of radix paeoniae rubra extract, 3-6 parts of magnolia bark extract, 1-2 parts of glossy privet fruit extract, 1-2 parts of gleditsia sinensis extract, 5-10 parts of camellia seed extract, 1-4 parts of pseudo-ginseng root extract, 1-2 parts of cortex dictamni extract, 1-3 parts of swertia extract, 1-4 parts of saw palmetto fruit extract, 2-5 parts of raspberry extract and 2-6 parts of phaeodactylum algae extract.