KR20120136583A - Composition for prevention of losing hair or promotion of growing hair - Google Patents

Abstract

PURPOSE: A composition containing soybean extract, Biota orientalis extract, linseed extract, or Glycyrrhiza uralensis extract is provided to improve blood circulation and to promote hair growth. CONSTITUTION: A composition for preventing hair loss or promoting hair growth contains soybean extract, Biota orientalis extract, linseed extract, or Glycyrrhiza uralensis extract as an active ingredient. A composition for promoting hair growth contains soybean extract, Biota orientalis extract, linseed extract, or Glycyrrhiza uralensis extract as an active ingredient. The extract is prepared using C1-C5 alcohols. [Reference numerals] (AA) Control group; (BB) Comparative embodiment; (CC) Embodiment 5

Description

Composition for prevention of losing hair or promotion of growing hair}

The present invention relates to a composition for preventing hair loss or promoting hair growth.

Most animals lose their hair at one time and newly hairy molt depending on the season, but a person loses about 100 hairs every day out of a total of about 100,000 hairs, and maintains a similar number at about 100 new hairs every day. .

The hair cycle can be roughly divided into three phases: growth, degeneration and rest. Among them, anagen is a time when active cell division occurs in the dermal papilla, which promotes the growth of new hair, and hair grows only during this period. Each hair has a growth period of about 3 to 5 years for men and 4 to 6 years for women, so about 80 to 85% of hair corresponds to growth. Catagen is a period in which cell division gradually stops, about three to four weeks. Finally, the talogen is the period when the hair papilla is atrophy and the hair is separated from the capillaries and simply lodged in the scalp. Hair that is about three months old and is at rest is usually easily pulled out by physical stimulation.

The present invention aims to provide a composition for preventing hair loss or promoting hair growth and promoting hair health.

One aspect of the invention is a soybean extract; And it provides a composition for preventing hair loss or hair growth comprising one or more extracts selected from the group consisting of baekbaek extract, flaxseed extract and licorice extract as an active ingredient.

Another aspect of the invention is a soybean extract; And it provides a composition for promoting hair health comprising at least one extract selected from the group consisting of white extract, flaxseed extract and licorice extract as an active ingredient.

Another aspect of the invention provides a cosmetic, food or pharmaceutical composition comprising the composition.

Composition according to the invention is a soybean extract; And one or more extracts selected from the group consisting of cypress extracts, flaxseed extracts and licorice extracts as active ingredients, thereby synergizing each component to improve blood circulation of capillaries, increase blood antioxidant capacity and reduce blood lipids. It clears blood and efficiently supplies nutrition to epithelial cells of hair roots. In addition, it stimulates the hair root and shows an excellent effect in inducing the activation of dermal papilla cells. In each hair, the effect of promoting hair growth is high by promoting the transition from the resting phase to the growth phase. Therefore, while suppressing the progression of hair loss and promoting hair growth, further prevent the aging of the hair and scalp and excellent hair health is very effective.

1 is a photograph showing the degree of hair growth of the mouse according to the application of the composition according to the present invention.

As used herein, "hair loss" refers to a phenomenon in which hair falls off the scalp or a condition in which the hair is coarse or thin, and "hair loss prevention" refers to preventing and inhibiting hair loss as described above, and "promoting hair growth." Means not only promoting the production of new hair, but also ensuring that existing hair grows healthy.

Hair growth is affected by several factors, including environmental factors such as temperature or sunlight, the nutritional status and disease of the individual, hormones, delivery, radiation or exposure to various drugs. The main causes of hair loss can be divided into physiological internal factors and external factors caused by the external environment. Physiological aspects of the body include 5-alpha reductase, which increases the secretion of sebum by converting testosterone and testosterone, which are known as androgens, to dihydrotestosterone (DHT). An increase in the activity of c. External factors caused by the external environment include lack of nutrient supply to the hair roots due to blood vessel atrophy caused by poor blood circulation, and drying of the scalp. Based on this, in order to prevent hair loss and promote hair growth, the blood vessels are expanded to nourish the hair roots well, or the components that have the same function as the components of the hair are directly supplied to the hair roots, or a detergent or sebum secretion inhibitor is used. To remove excess sebum in the hair root area or to prevent drying of the scalp using a moisturizing agent.

One aspect of the invention is a soybean extract; And it provides a composition for hair, specifically for hair loss prevention or hair growth promoting and hair health composition comprising at least one extract selected from the group consisting of baekbaek extract, flaxseed extract and licorice extract as an active ingredient.

In one aspect of the present invention, the soybean extract may be an extract extracted using a low concentration of an organic solvent instead of a high concentration of an organic solvent generally used as an extraction solvent in a natural product extraction method. Extracts by low concentration of organic solvents have superior effect of inducing activation of dermal papilla cells to promote proliferation and activating blood circulation by activating blood circulation, nourishing hair roots, compared to conventional extracts, preventing hair loss, The effect of promoting hair growth and promoting hair health is excellent.

In one aspect of the invention, the organic solvent comprises a lower alcohol, specifically C ₁ ~ C ₅ alcohol. The C ₁ ~ C ₅ alcohol, for example, may be any one or two or more mixed solvents selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol, specifically Ethanol may be, but is not limited thereto. In another aspect of the invention, the concentration of the organic solvent is 1 to 70% (v / v), specifically 1 to 40% (v / v), more specifically 5 to 30% (v / v) And even more specifically 12 to 25% (v / v).

In one aspect of the invention, soybean includes all the soybean extract has the effect of preventing hair loss, promoting hair growth or promoting hair health. In another aspect of the invention, the soybean comprises black beans or colored beans. In another aspect of the invention, the soybean is from the group consisting of frosted, seomoktae, blacktae, yellow, green pea (cheongtae), kidney beans, green beans, fence beans, green beans, red beans, soybeans, bean sprouts, seonbi and soybeans It includes one or more selected.

As used herein, the term "black bean" is a generic term for beans whose color of the grain husk is black. Examples of the black soybeans include, but are not limited to, seoritae, seomoktae and blacktae. The name of black beans can be variously called by the influence of region, classification, and dialect. As used herein, the term “black bean extract” refers to a material extracted from black beans through various extraction methods, and includes, for example, a material extracted using an organic solvent, various fractions of the extracted material, and the like. .

In the present specification, the term "colored-bean" refers to beans having a dark color of the grain husk, and encompasses beans having a color such as red, yellow, or blue as well as black. Examples of the colored beans include, but are not limited to, frosted, seomoktae, blacktae, yellow, green soybeans, kidney beans, stained kidney beans, hedge beans, green beans, red beans, soybeans, bean sprouts, sesame beans or soybeans, but is not limited thereto. . The name of colored beans can be variously called by the influence of region, classification and dialect. As used herein, the term "colored soybean extract" refers to a substance extracted from colored beans through various extraction methods, and includes, for example, a substance extracted using an organic solvent, various fractions of the extracted substance, and the like. .

In one aspect of the present invention, the biota orientalis includes the young branches or leaves of the cypress belonging to the genus Cypressaceae. White matter extract blackens hair and promotes hair growth. Flaxseed is also known as flax seed, flax (Linum usitatissimum . ) Seeds. Flaxseed extract contains a large amount of female hormones, which can reduce the loss of male hormones. Licorice is licorice ( Glycyrrhiza uralensis ) includes all of the leaves, stems, or roots. Licorice extract may contain a large amount of isoflavone that lowers the blood concentration of DHT, which acts on the hair root and inhibits hair growth, and may exhibit hair loss prevention and hair growth promoting effects.

The white leaf extract, flaxseed extract and licorice extract may be extracts obtained by using conventional methods in the art with water or a lower alcohol having 1 to 5 carbon atoms, flaxseed or licorice, respectively. For example, specifically, the extract is added 0.1 to 10 l, specifically 0.5 to 7 l of water per kg of the raw material as the extraction solvent and 3 to 6 hours at 20 to 90 ℃, specifically 70 to 80 ℃, specifically It may be an extract extracted by refluxing for 4 hours.

The composition according to an aspect of the present invention further comprises one or more extracts selected from the group consisting of baekbaek extract, flaxseed extract and licorice extract with soybean extract extracted with a low concentration of organic solvent, thereby preventing hair loss through synergistic action It can have a very good effect in promoting. Specifically, the composition promotes proliferation by activating dermal papilla cells, dilates capillaries, removes oxidized components in the blood, reduces blood neutral lipids, and activates blood circulation to nourish hair roots. It also promotes transition to the growth phase for hair at rest. Through such action, the composition has an excellent effect of preventing hair loss and promoting hair growth, and further, preventing hair aging, increasing hair gloss, and strengthening the hair root to enhance hair health.

The composition according to one aspect of the invention comprises 0.001 to 90% by weight, specifically 1.0 to 70% by weight, more specifically 5.0 to 50% by weight, based on the total weight of the composition. The composition according to one aspect of the present invention is 0.001 to 90% by weight, specifically 1.0 to 70% by weight, more specifically 5.0 to 50% by weight in the group consisting of baekbaek extract, flaxseed extract and licorice extract based on the total weight of the composition At least one extract selected. When included in the weight percent, not only is it appropriate to exhibit the intended effect of the present invention, but also satisfies both the stability and safety of the composition, it may be appropriate to include in the above range in terms of cost-effectiveness.

In one aspect of the present invention, the composition comprises one or more extracts selected from the group consisting of soybean extract, baekyek extract, flaxseed extract and licorice extract 10: 1 to 1:10, specifically 5: 1 to 1: 5, more specifically It is included in the weight ratio of 3: 1 to 1: 3. When included in the ratio is not only appropriate to exhibit the intended effect of the present invention, it can satisfy both the stability and safety of the composition, it may be appropriate to be included in the above range in terms of cost-effectiveness.

One aspect of the present invention provides a cosmetic composition comprising a composition comprising one or more extracts selected from the group consisting of soybean extract and baekbaek extract, flaxseed extract and licorice extract.

The cosmetic composition may be provided in any formulation suitable for topical application. For example, it may be provided as a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an oil phase in water, a suspension, a solid, a gel, a powder, a paste, a foam or an aerosol composition. Compositions of such formulations may be prepared according to conventional methods in the art.

The cosmetic composition may contain, in addition to the above-mentioned materials, other ingredients that can give a synergistic effect to the main effect within a range not impairing the main effect. The cosmetic composition according to the present invention may include a substance selected from the group consisting of vitamins, polymer peptides, polymer polysaccharides and sphingolipids. In addition, the cosmetic composition according to the present invention may include a moisturizer, an emulsifier, a surfactant, a ultraviolet absorber, a preservative, a fungicide, an antioxidant, a pH adjuster, organic and inorganic pigments, flavoring agents, cooling agents or limiting agents. . The blending amount of the above components can be easily selected by those skilled in the art within the range that does not impair the object and effect of the present invention, the blending amount may be 0.01 to 5% by weight, specifically 0.01 to 3% by weight based on the total weight of the composition. have.

One aspect of the invention provides a food composition comprising a composition comprising one or more extracts selected from the group consisting of soybean extract and baekbaek extract, flaxseed extract and licorice extract.

The formulation of the food composition is not particularly limited, but may be, for example, formulated into tablets, granules, drinks, caramels and the like. In addition to the active ingredient, the food composition of each formulation may be appropriately selected and formulated by those skilled in the art according to the formulation or purpose of use, in addition to the active ingredient, and synergistic effects may occur when applied simultaneously with other ingredients.

Determination of the dosage of the active ingredient is within the level of those skilled in the art, the daily dosage of which is for example from 0.1 mg / kg / day to 5000 mg / kg / day, more specifically from 50 mg / kg / day to 500 mg / kg / day, but is not limited thereto and may vary depending on various factors such as age, health condition, complications, etc. of the subject to be administered.

One aspect of the present invention provides a pharmaceutical composition comprising a composition comprising one or more extracts selected from the group consisting of soybean extract and baekbaek extract, flaxseed extract and licorice extract. In another aspect of the invention, the pharmaceutical composition may exhibit the effect of preventing or treating hair loss, promoting hair growth, and promoting hair health.

The pharmaceutical composition according to one aspect of the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, and the like. Formulations for oral administration may be tablets, pills, soft and hard capsules, granules, powders, granules, solutions, emulsions or pellets, but are not limited thereto. It is not. Formulations for parenteral administration may be, but are not limited to, solutions, suspensions, emulsions, gels, injections, drops, suppositories, patches or spray formers. The formulations may be readily prepared according to conventional methods in the art and may be prepared by conventional means including, but not limited to, surfactants, excipients, wetting agents, emulsifying accelerators, suspending agents, salts or buffers for controlling osmotic pressure, colorants, spices, stabilizers, preservatives, Other commonly used adjuvants may be used.

The active ingredient of the pharmaceutical composition according to one aspect of the present invention will vary depending on the age, sex, weight, pathology and severity of the subject to be administered, the route of administration or the judgment of the prescriber. Dosage determination based on these factors is within the level of one skilled in the art, the daily dosage of which is for example from 0.1 mg / kg / day to 5000 mg / kg / day, more specifically from 50 mg / kg / day to 500 mg / kg May be, but is not limited to.

Hereinafter, the structure and effect of the present invention will be described in more detail with reference to Comparative Examples, Examples and Test Examples. However, these Examples, Comparative Examples and Test Examples are provided only for the purpose of illustration in order to help the understanding of the present invention, but the scope and scope of the present invention is not limited thereto.

Comparative Example Preparation of Soybean Extract

1 kg of dried frosted rice was immersed in 10 L of 10%, 20%, 50% and 70% (v / v) of (v / v) ethanol solution at 50 ° C., respectively, and refluxed three times for 5 hours. Left for 12 hours. The extract was filtered, concentrated under reduced pressure, and freeze-dried to prepare a powder sample. The yield was 7-20%, and the prepared powder was stored at low temperature until use.

Example Preparation of Complex Extract

Examples 1 to 6 were prepared by mixing at least one of soybean extract extracted with 20% ethanol and comparative extract, flaxseed extract and licorice extract extracted with water in the comparative example. The active ingredient contained in each Example and the weight ratio of each component are as follows.

Weight ratio Bean extract Cypress extract Flaxseed extract Licorice extract Example 1 One One - - Example 2 One - One - Example 3 One - - One Example 4 One One One - Example 5 One One - One Example 6 One One One One

[Test Example 1] Evaluation of the effect of promoting promotion of dermal papilla cells

PVGDPLTt sa produced by transfecting a polyomavirus large T gene that encodes a temperature sensitive T antigen to a PVG vibrissa dermal papilla cell 6. Hereinafter, the effect of promoting dermal papilla cell proliferation of the composition according to the present invention was evaluated.

First, DP cells were prepared in 96-well plates at a concentration of about 10 ⁴ cells / well per well. Examples 1 to 6 and Comparative Examples were dissolved in DMSO (dimethyl sulfoxide) or ethanol, respectively, and serial dilution was performed with DMEM medium having a 5% FBS serum concentration so that the final concentration was 10 ppm. As a comparative example, a soybean extract extracted with 20% ethanol was used. 200 μl of the medium to which Examples 1 to 6 and Comparative Example were added were added per well, and then cultured in a 37 ° C., 5% CO ₂ incubator for about 3 days. 50 μl of each MTT solution was added at a concentration of 2 mg / ml, and then left in the same incubator for 4 hours. When it was determined that the MTT reagent was absorbed into the intracellular mitochondria, the supernatant was removed, 150 μl of DMSO was added, and then stirred for 10 minutes to uniformly dissolve promazan dye. Then, the OD value was measured at 515 nm using an ELISA reader, and the number of cells was measured according to a standard curve prepared in advance. Based on the measured cell number, the dermal papilla cell proliferation promoting ability (%) of Examples 1 to 6 and Comparative Examples was calculated and the results are shown in the table below.

Comparative example Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Hair papilla cell proliferation promoting ability (%) 42.1 ± 1.2 45.6 ± 1.5 44.6 ± 0.4 52.1 ± 1.2 60.9 ± 0.9 72.3 ± 3.4 58.9 ± 1.1

As can be seen above, the dermal papilla cell proliferation promoting effect of Examples 1 to 6, which includes at least one of soybean extract, white powder extract, flaxseed extract, and licorice extract, was superior to the comparative example containing only soybean extract. In particular, the soybean papilla cells proliferation promoting effect of Example 5, including soybean extract, white matter extract and licorice extract was the best. Therefore, the composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract has a synergistic effect in promoting the growth of dermal papilla cells, thus preventing hair loss, promoting hair growth, and further promoting hair health. It can be seen.

Test Example 2 Evaluation of Capillary Expansion Effect

Opening the K ⁺ channel activates mitogenesis and relaxes the vascular smooth muscles, causing blood vessels to expand. On the other hand, blocking the K ⁺ channel is known to inhibit the proliferation of NIH3T3 fibroblasts. Therefore, when the growth of NIH3T3 fibroblasts by sample processing is promoted, it can be said that the K ⁺ channel is opened, and further expansion of blood vessels is promoted.

First, NIH3T3 fibroblasts were seeded in a 24-well culture plate at a concentration of 10 ⁴ cells / well, and then in 24 in DMEM medium containing 10% fetal calf serum (FCS) and 2 mM L-glutamine and no antibiotics. Time incubation. Then, the culture medium was replaced with the medium to which Examples 1 to 6 and Comparative Example were added, respectively, and cultured for 72 hours. The medium production method to which Examples 1 to 6 and Comparative Examples were added was the same as Test Example 1, and as a comparative example, soybean extract extracted with 20% ethanol was used. After removing the medium, washed with PBS (without Ca ^{2 +} / Mg ^{2 +} ), treated with 0.5ml TE (trypsin-ethylenediamine tetraacetic acid) and incubated. DMEM containing 10% FCS was added, the cells were harvested and centrifuged at 6000 rpm in EP tubes. The supernatant was removed and the remaining cell solution was suspended in 100 µl of PBS, and then the number of cells was measured using a hemocytometer. Based on this, capillary dilatation capacity of Examples 1 to 6 and Comparative Examples was calculated and shown in the following table.

Comparative example Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Capillary dilatation capacity (%) 34.1 ± 2.2 36.6 ± 0.5 44.6 ± 3.6 42.1 ± 4.2 56.6 ± 1.9 69.3 ± 2.4 63.1 ± 1.1

As can be seen above, the capillary dilatation effect of Examples 1 to 6, which includes at least one of soybean extracts, baekrye extracts, flaxseed extracts, and licorice extracts, was better than the comparative examples comprising only soybean extracts. In particular, the capillary dilatation effect of Example 5, including soybean extract, white matter extract and licorice extract was the best. Therefore, a composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract has a synergistic effect in improving blood circulation of the scalp capillaries, thus promoting hair health, inhibiting the progression of hair loss, and promoting hair growth. It can be seen that the effect is better.

Test Example 3 Evaluation of Hair Growth Promotion Effect

The hair growth promoting effect of the mouse was evaluated using the soybean extract extracted with 20% ethanol of the comparative example and Example 5. First, the back hairs of 47-53 day old mice (C57BL / 6) were removed with an electric clipper. Mouse hair of this age is characterized in that it does not grow immediately because it is in the resting phase. Among them, the mice with good back skin were selected and divided into three groups to include 5-7 mice per group, and then reared in a separate case. Cereal feeds prepared so that Comparative Example and Example 5 were included at 0.6% were freely consumed through the diet. One group was taken as a control group to consume the cereal feed containing no active ingredient according to the present invention. After 23 days, changes in the hair removal site of each group were observed, and a photograph thereof is shown in FIG. 1. In addition, the hair of each newly grown mouse at the epilation site was collected with an electric clipper and weighed. The results are shown in the table below.

Control group Comparative example Example 5 Hair weight (mg) 42.1 ± 16.2 76.1 ± 8.2 118.5 ± 10.4

As can be seen above, the application of a composite composition comprising at least one of a soybean extract, a white bean extract, a flaxseed extract and a licorice extract is not only applied to both but also to a mouse hair. Promoted growth. This can be seen from the appearance shown in Figure 1 and the hair weight of Table 4. Therefore, it can be seen that the composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract has an excellent hair growth promoting effect.

Test Example 4 Evaluation of Antioxidant Activity of Blood

(1) taking blood samples and separating plasma

At the end of Test Example 3, 200 μl of blood samples were taken from the eye vessels of each group of mice, which were separated into blood cells and plasma by centrifugation (3000 rpm, 10 minutes). Supernatants were taken and stored in 1.7 ml micro E-tubes and frozen until just before analysis.

(2) Evaluation of free radical scavenging ability of plasma

ABTS solution was prepared by adding ABTS (2,2'-Azino-bis (3-ethylbenzthiazoline 6-sulfonic acid)) to 0.05M phosphate-citrate buffer at pH 5.0 to a final concentration of 150M. . The ABTS solution was reacted with hydrogen peroxide (H ₂ O ₂ ) and peroxidase (methmyoglobin) to 75M and 2.5M, respectively, to generate ABTS radicals. 20 L of plasma samples from each group were added to 180 L of ABTS radical solution, mixed thoroughly, and then reacted for 60 minutes by shading at room temperature. After the reaction was completed, the absorbance of the sample was measured at 600 nm. At the same time, a trolox sample was prepared in which a final concentration of trolox was 10 mM, 2 mM, 1 mM, 100M, and 10M in 0.05M phosphate-citrate buffer at pH 5.0. Using the ABTS radical solution, the Trolox sample was reacted and absorbance was measured in the same manner to prepare a standard curve. Based on this, the absorbance values of each group of samples were calculated as the value of Trorolox Equivalence Antioxidant Activity (TEAC), which is shown in the table below. TEAC is a measure of the free radical scavenging ability of a sample in terms of the equivalent amount of trolox that has the equivalent activity.

Test group TEAC (mM) Control group 0.71 ± 0.7 Comparative example 0.84 ± 1.7 Example 5 0.95 ± 0.15

As can be seen above, the application of a composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract is not only applied to the blood but also to the blood than the composition containing only the soybean extract. The antioxidant activity was excellent. Therefore, a composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract has the effect of improving the blood circulation by removing oxidizing substances in the blood, thereby promoting hair health, inhibiting the progression of hair loss, and promoting hair growth. You can see that even better.

Test Example 5 Evaluation of Blood Neutral Lipids

Plasma prepared in the same manner as in Test Example 4 was analyzed for neutral lipids in blood using an automatic blood chemistry analyzer (Selectra E; Vital Scientific). The results are shown in the table below.

Test group Neutral Lipid (mg / dL) Control group 68.5 ± 4.5 Comparative example 63.6 ± 6.3 Example 5 52.6 ± 4.8

As can be seen above, the application of a composite composition comprising at least one of soybean extract, white bean extract, flaxseed extract and licorice extract is more neutral than the case of applying a composition containing only soybean extract as well as none. The effect of reducing lipids was excellent. Therefore, the composite composition comprising one or more of soybean extract, white bean extract, flaxseed extract and licorice extract improves blood circulation by reducing neutral lipids in the blood, thereby promoting hair health, inhibiting the progression of hair loss, and promoting hair growth. It can be seen that even better.

Examples of the formulation of the composition are described below, but are not intended to limit the present invention but merely to be described in detail.

Formulation Example 1 Soft Capsule

100 mg of frost extract, 50 mg of soy extract, 50 mg of soybean extract, 50 mg of flaxseed extract, 50 mg of licorice extract, 180 mg of soybean oil, 2 mg of palm oil, 8 mg of palm hardened oil, 4 mg of lead and 6 mg of lecithin, According to 400 mg per capsule to prepare a soft capsule.

Formulation Example 2 Tablet

100 mg of fermented soybean extract, 50 mg of currant extract, 50 mg of licorice extract, 100 mg of glucose, 96 mg of starch and 4 mg of magnesium stearate, and 40 mg of 30% ethanol were added to form granules. Tablet to tablet using.

[Formulation Example 3] Drinks

100 mg of Seomoktae extract, 50 mg of flaxseed extract, 50 mg of licorice extract, 10 g of glucose, 2 g of citric acid and 187.8 g of purified water are mixed and filled into bottles. The final dose of the contents is 200 ml.

Formulation Example 4 Healthy Food

Surita extract .................................... 1000 mg

White leaf extract ............................ 1000 mg

Vitamin mixtures

Vitamin A Acetate ......... 70 μg

Vitamin E ............................. 1.0 mg

Vitamin B1 ........................................ 0.13 mg

Vitamin B2 ........................... 0.15 mg

Vitamin B6 ............... 0.5 mg

Vitamin B12 ............ 0.2 μg

Vitamin C ................................. 10 mg

Biotin .................................... 10 μg

Nicotinamide ......................................... 1.7 mg

Folic acid ......................................... 50 ㎍

Calcium Pantothenate ......................................... 0.5 mg

Mineral mixture

Ferrous Sulfate ............................. 1.75 mg

Zinc Oxide ..................... 0.82 mg

Magnesium Carbonate ........................... 25.3 mg

Potassium monophosphate ............... 15 mg

Dicalcium Phosphate Dibasic ............... 55 mg

Potassium citrate ............... 90 mg

Calcium Carbonate ......................... 100 mg

Magnesium Chloride ............... 24.8 mg

Although the composition ratio of the said vitamin and mineral mixture has mixed the composition suitable for a healthy food relatively, you may arbitrarily modify the compounding ratio, The above-mentioned components are mixed according to a normal health food manufacturing method, and then granules are manufactured. It can be used for producing a health food composition according to a conventional method.

 Formulation Example 5 Cream

Creams are prepared by conventional methods according to the compositions listed in the table below.

Compounding ingredient Content (% by weight) Black Tae Extract 3.0 Cypress extract 3.0 Flaxseed extract 3.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

Those skilled in the art to which the present invention pertains will be able to perform various applications and modifications within the scope of the present invention based on the above contents.

Claims (12)

Soy extract; And
A composition for preventing hair loss or promoting hair growth comprising at least one extract selected from the group consisting of white powder extract, flaxseed extract and licorice extract as an active ingredient.
Soy extract; And
A composition for promoting hair health, comprising as an active ingredient one or more extracts selected from the group consisting of white powder extract, flaxseed extract and licorice extract.
3. The method according to claim 1 or 2,
The soybean is composition comprising at least one selected from the group consisting of frosted, seomoktae, blackened, yellow, green, soybeans, kidney beans, green beans, hedge beans, mung beans, red beans, soybeans, bean sprouts, seonbi and soybeans.
3. The method according to claim 1 or 2,
The composition comprises 0.001 to 90% by weight of soy extract based on the total weight of the composition.
3. The method according to claim 1 or 2,
The composition comprises from 0.001 to 90% by weight of one or more extracts selected from the group consisting of 0.001 to 90% by weight of a white leaf extract, flaxseed extract and licorice extract based on the total weight of the composition.
3. The method according to claim 1 or 2,
The composition comprises a one or more extracts selected from the group consisting of soybean extracts and baekrye extract, flaxseed extract and licorice extract in a weight ratio of 10: 1 to 1: 10.
3. The method according to claim 1 or 2,
The composition improves blood circulation in the scalp to nourish the hair roots.
3. The method according to claim 1 or 2,
Bean extract is a composition of 1% to 70% (v / v) C ₁ ~ C ₅ alcohol extract.
3. The method according to claim 1 or 2,
C ₁ ~ C ₅ alcohols comprise one or more selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol.
Cosmetic composition comprising a composition according to claim 1.
A food composition comprising the composition of claim 1.
A pharmaceutical composition comprising the composition of claim 1.

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