KR100331675B1 - External skin preparation - Google Patents

Abstract

(Purpose) Providing skin external preparations with skin whitening effect, hair growth, wool effect and anti-aging effect.

(Composition) Skin external preparation The skin external preparation comprising 0.001 to 10% (w / w) of the extract of the rhododendron plant in the weight in terms of dry solids.

(Effect) It shows excellent skin function, hair growth, wool effect, moisturizing effect and skin whitening effect by skin function and hair root cells.

Description

Skin external preparations

The present invention does not have significant side effects on the living body, such as hormones, etc., has excellent skin function improvement and hair growth and hair effect by the skin function and hair root cells' hyperactivity, The present invention also relates to a skin external preparation composition obtained by distributing an extract of an arrowhead plant, such as a sapling tree, a cedar tree, or a succulent tree, as an essential ingredient, having an excellent moisturizing and whitening effect.

Many studies have been conducted on hormonal agents, blood stimulators, and various cell activating ingredients for the whitening effect for the prevention and treatment of skin aging, blemishes, and freckles, and for the hair growth and wool action caused by the continuous enhancement of the scalp and hair roots. Various active ingredients have been tried and blended. However, if the effectiveness is evaluated objectively with respect to the component which is still very effective and the stability is high and its medicinal effects, most of them remain in the expression of preventive effect.

The present invention has excellent safety and safety, has a whitening effect due to the function of promoting skin function, and a treatment effect of alopecia due to hair growth and wool effect, and has an excellent preventive effect on people who do not develop alopecia, and also has a promoting effect and skin It is intended to develop external preparations for the skin with anti-aging action.

The external preparation for skin of the present invention is characterized in that the external preparation of the skin is formulated with an essential ingredient of an extract of a cedar plant, such as sapling, cedar, and succulent.

The second external preparation for skin of the present invention is characterized by a combination of an arrowwood plant extract and another component known to be blended into the external preparation.

The external preparation for skin of the present invention is particularly used as a wool skin cosmetic since it has a hair growth and wool action.

The plant of the Euonymus is a plant of the tree of the apophytica, the family of the Arrow family, and is widely distributed in Japan and China, and some of them are planted as garden trees or hedges. (暖 帶) A woody plant distributed in the province.

As a kind of the rhododendron plant to be used in the present invention, the representative rhododendron is Euonymus alata Sieb., Euonymus japonica Thunb., Euonymus radicons Sieb. Trees, large cedar trees, small cedar trees, kawashi cedar trees, baby cedar trees, large string cedar trees.

The extract of the Rhizome plant extract of the present invention may be any of the leaves, stems, roots of the Rhododendron plant, may be used alone or together as a raw material for extraction, and may be used separately as a root, a stem, etc. You can use the extracted ingredients together as needed. Similarly, the extracting plant, which is a raw material, does not need to be a single plant, but may be used in combination of two or more kinds, such as arrow and cedar.

As the extraction method, for example, the whole of the stem part of the arrow tree may be cut finely, and the juice may be used as a semi-fluid liquid in a homogenizer, or the juice may be concentrated and used. The extract may be extracted by adding a suitable solvent to a finely chopped plant or a semi-flowing liquid by a homogenizer, evaporating the supernatant in a freeze dryer, and formulating this component into an external preparation for skin, and the like.

As the extraction solvent, one or two or more selected from hydrophilic solvents such as water, ethanol, n-propanol, t-butanol, propylene glycol, 1,3-butylene glycol, hydrophobic solvents such as chloroform and diethyl ether, or There is a mixed solvent. Extraction may be performed at room temperature or may be heated or heated. In the solvent extraction method, the plant may be a dried or semi-dried body as well as a plant.

The solvent extract is used by concentrating or concentrated drying as necessary to facilitate subsequent operations. In this case, if necessary, components which are not considered to affect the activity, such as starch contained in the solvent extract, may be used. You may precipitate out by a method.

The extract of the cedar plant is 0.001 to 1.0% (w / w), preferably 0.01 to 5% (w / w) in the skin external preparation of the present invention in weight (w) in terms of dry matter. You can do it.

Although the specifics of the active ingredient contained in the arrowwood plant extract acting as an essential ingredient in the external preparation for skin of the present invention are unknown until now, sterols, flavonoids, alkaloids, saponins, organic acids, It is assumed that any of organic compounds such as coumarin compounds exhibits excellent cell function promoting action and moisturizing action of the present invention.

The present inventors have been conducting research and development for a long time on the action of the rhododendron plant extract on the hair root cells and skin cells, and thus have completed the present invention.

In examining the action effect of the external preparation for skin of the present invention, the effect on skin cells and hair root cells was examined using cultured cells and experimental animals. One experimental example is described below.

Experimental Example

Dorsal hair of C3H mouse male (6 weeks old), which is generally used as an experimental animal for evaluation of the effect of hair growth, is completely removed (hand area of about 4 cm 2) by 60% as a test solution. Regeneration of hairs from 10% of two groups (5 groups) in 60% alcohol solution as a control in comparison with 1% of cedar tree extracts in which 1% amount of the extract of cedar leaf and stem was dissolved in an aqueous solution of alcohol. It was applied for 25 days in succession 200 μl once daily until the end.

On the 13th, 15th, and 19th day of the application of the test solution, 20 hairs were collected from each animal, and their lengths were measured by an enlarged measurement method, and their effectiveness was evaluated by computerized calculation and statistical analysis. It was. The results are shown in the table below.

* Indicates a significant difference of 1% in the risk of comparison between the two groups by statistical analysis (T test).

From the results of this experimental example, it can be seen that the component according to the present invention has a hair growth and hair growth effect due to excellent skin function enhancement that promotes the growth of skin and hair of a living body.

Although the details of the mechanism of these actions are unknown, any active ingredient in the plant extract of the present invention penetrates into the skin to activate the cells of the skin and hair roots, and also promotes the development of capillaries, which are greatly involved in hair growth, It is thought to be caused by maintaining the health of the scalp and hair by directly promoting the function of the cells.

In order to further enhance the hair growth and wool promoting effect by the extract of the present invention, the present invention, (3-carboxypropyl) -trimethyl ammonium chloride methyl ester, 6-amino-1,2- Dihydrodohydroxyimino-4-piperidinopyridinine, 7-chloro-3-methyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide, polyoxyethylene sorbitan monostearate (20 EO), the extract of the early spring extract of the gentian family, the ethynyl estradiol, the extract of Yeonmyeongcho, and the red ginseng extract were also examined.

As a result, the present inventors found that the known hair growth / wool component exhibits a synergistic effect of hair growth and wool promotion by an excellent skin hyperactivity by complexing with the extract of the alder plant, and completed the second invention. . 20 E.O. represents 20 molecules of ethylene oxide.

In addition to the hair growth and wool components, a combination of a skin stimulating component, a cholinergic component, an adrenergic inhibitory component, and a vascular smooth muscle relaxation component, which have a known skin blood circulation promoting effect, and the arrowwood plant extract of the present invention As a result of examination of the effect of external preparations such as wool promotion, higher efficacy was also found for these components.

In addition, by increasing the percutaneous absorption rate of the Rhizome plant extract, the increase in the effect that is thought to be due to the increase in the absorption rate into the skin is confirmed by combining a moisturizer, a keratin softener, and a surfactant frequently used in cosmetics in the external preparation of the present invention. It became.

In the present invention, the compound concentration of the Alder plant extract used as the external preparation for skin is preferably about 0.01 to 5.0%. The concentration of (3-carboxypropyl) -trimethylammonium chloride methyl ester blended with the hair growth and wool promoter containing 0.01 to 5.0% of the concentration of the cypress plant extract is preferably about 0.01 to 5.0%. Likewise, the blending concentration of 6-amino-1,2-dihydrohydroxyimino-4-piperidinopyridinine is preferably 0.01 to 5.0%. The compounding concentration of 7-chloro-3-methyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide is preferably about 0.01 to 5.0%. The blending concentration of polyoxyethylene sorbitan monostearate (20 E.O.) is preferably about 1.0 to 60.0%. As for the compounding density of the extract of the beginning of the year of gentian fruit (1 g of dry weight is equivalent to 1 g of extract), about 0.01 to 5% is preferable. The compounding concentration of ethynyl estradiol is preferably about 0.001 to 0.1%. As for the compounding density | concentration of an extract of an extract of 1 year old (1 g of dry weight is corresponded to 1 g of extracts), 0.01-10.0% is preferable. As for the compounding density of the high ginseng extract (1 g of dry weight is equivalent to 1 g of extract), about 0.01-10.0% is preferable.

The compounding concentration of ingredients known to have anti-aging effects by inhibiting lipid peroxide generation is preferably, for example, 0.01 to 10.0% of gold, 0.1 to 5% of vitamin E, and 0.01 to 10.0% of aloe.

Skin moisturizers include glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, diethylene glycol, PEG (polyethylene glycol), ethyl hexanediol, sugar alcohols (such as sorbitol), mucopolysaccharides (such as hyaluronic acid salts). , Chondroitin sulfate, PCA salt, etc.), and those used in this kind of field can be used, and the compounding concentration can be in the range usually used, preferably 0.1 to 10%.

Examples of keratin softeners include salicylic acid and urea, and the compounding concentration is used at 0.1 to 10%. Examples of the anionic surfactants include N-lauroyl glutamic acid hydrochloride, and nonionic surfactants include decaglyceryl monolaurate, polyoxyethylene sorbitan, and polyoxyethylene hydrogenated castor oil. The compounding concentration is preferably 0.1 to 5.0%. Do.

As the base used in the hair growth and wool promotion agent of the present invention, in addition to the bases such as creams, gel creams, ointments, etc., which are conventional bases, in addition to the aqueous agent which is a base used for external preparations, alcohol solvents, make-up such as foundation and lipstick Cosmetics, cleaning agents such as shampoo, rinse, soap, and bathing agents can also be used, but the excellent effects of the present invention have been sufficiently shown by these bases.

Production Example

As a manufacture example, although the specific example of the extraction method of an arrowhead plant extract is demonstrated, it is not limited to these extraction methods.

Preparation Example 1

The leaves and stems of the cedar tree are mixed as it is, and finely chopped, the juice is filtered, and then the chlorophyll is removed in a centrifuge, and the water is evaporated.

Preparation Example 2

The leaves and stems of the arrow are finely immersed in an equivalent amount of ethanol, and the extract is heated with ethanol in an extractor for 8 hours. The extract is cooled, filtered and the solvent is evaporated. do.

Preparation Example 3

The leaves and roots of the cedars were finely chopped and immersed in an equivalent amount of propylene glycol: distilled water = 1: 1 solvent, immersed in a batch method at 50 ° C. for 24 hours, cooled, filtered and the solvent was evaporated. It is used for this invention as an extract.

Example

Some of the embodiments of the present invention are described below, but the present invention is not limited to these examples.

The external preparation of this invention may mix | blend the component which is conventionally useful with respect to skin and hair other than the component shown to the following example.

Example 1

According to the following formulation, a gel wool cosmetic having excellent wool effect was prepared by a conventional method.

Example 2

The lotion wool cosmetics which were excellent in the wool effect by the conventional method by the following prescription were manufactured.

In the above, POE represents polyoxyethylene and E.O. represents ethylene oxide.

Example 3

The lotion wool cosmetics which were excellent in the wool effect by the conventional method by the following prescription were manufactured.

Example 4

Example 5

Example 6

According to the following formulation, a wool shampoo cosmetics excellent in wool effect were prepared by a conventional method.

In the above, PEO stands for polyoxy ethylene.

Example 7

According to the following formulation, a wool rinse cosmetic having excellent wool effect was prepared by a conventional method.

In the stomach, PEO means polyoxyethylene.

Example 8

A cosmetic cream having excellent skin anti-aging and whitening effect was prepared by the following formulation.

Example 9

A cosmetic cream having excellent skin anti-aging effect and whitening effect was prepared by the following prescription.

Example 10

A cosmetic cream having excellent skin anti-aging effect and whitening effect was prepared by the following prescription.

Example 11

The lip balm was prepared with the following moisturizing effect and excellent cell activation of the lips.

Test Example

As a group of four to seven male health workers aged 31 to 51 who showed symptoms of mature alopecia as a group, the test solution was applied for about three milliliters (3 ml) once or twice a day for three months. Got it.

(Criteria)

After 3 months, the occurrence of new hair on the coated area, hair growth, etc. were evaluated by the hair density measurement method which measures the number of hairs of the hair per unit area, and the SCORE determination method which judges by photographing. It was. The criteria for the SCORE judgment are as follows.

SCORE 1 Very little hair and only slight hair growth.

SCORE 2 A large number of hairs and some hairs on the bald area.

SCORE 3 There is dense hair on the bald area and about half of the hairs are seen.

SCORE 4 Covered entirely, but with scalp.

SCORE 5 Hair loss and thin hair are not seen at all.

The case of improvement by one rank or more in accordance with the SCORE decision is valid.

(result)

1) The effective rate of the hair growth / hair promoting agent, which is an external preparation for skin of the present invention containing 1.0% of the ethanol extract of arrow-tree plant in Base 1, was 74.5%.

2) The effective rate of the hair growth and wool promoter which contained 1.0% of (3-carboxypropyl) -trimethylammonium chloride methyl ester and 0.5% of cedar plant ethanol extract in the base 1 was (3-carboxypropyl) -trimethylammonium chloride The synergistic effect of the cedar plant ethanol extract was 6.2% higher than the effective rate of the hair growth and wool promoter containing 1.0% methyl ester.

3) The effective rate of the hair and wool promoter which contained 1.0% of 6-amino-1,2-dihydrohydroxyimino-4-piperidinopyrimidine and 0.5% of cedar ethanol extract in the base 2 was 6- The synergistic effect of cedar plant ethanol extract was 9.8% higher than the effective rate of hair growth and wool promoters containing 1.0% of amino-1,2-dihydrohydroxyamino-4-piperidinopyrimidine.

4) Hair growth and wool promoters containing 1.0% of 7-chloro-3-methyl-2H [benzo-1,2,4-thiadiazine] -1,1-dioxide and 1.0% of the ethanol extract of cedar plants in the base 3 The effective rate of is 12.1% higher than the effective rate of the hair and wool promoter which contained 1.0% of 7-chloro-3-methyl-2H- [benzo-1,2,4-thiadiazine] -1,1-dioxide in the base 3 Synergistic effect by the ethanol extract of the cedar tree plant was shown.

5) The effective ratio of hair growth and wool promoters containing 50% of polyoxyethylene sorbitan monostearate (20 EO) and 0.5% of cedar plant ethanol extract in base 1 was determined in terms of polyoxyethylene sorbitan monostearate (20 The synergistic effect of the cedar plant ethanol extract was 8.5% higher than the effective rate of hair growth and wool promoters containing 50% of EO). And the amount of the base water was reduced by the compounding amount of polyoxyethylene sorbitan monostearate (20 E.O).

6) The effective ratio of hair growth and wool promoters containing 1.0% (corresponding to 1 g of dry weight) and 0.5% of cedar plant ethanol extracts based on Base 1 was 1.0% based on Base 1 The synergistic effect of the cedar plant ethanol extract was 7.4% higher than the effective rate of the hair growth and wool promoter contained in% (equivalent to 1 g of dry weight).

7) The effective rate of hair growth and wool promoters containing 0.1% of base 1 ethynyl estradiol and 0.5% of cedar plant ethanol extract was 6.9% higher than that of hair growth and wool promoters containing 0.1% of base 1 ethynyl estradiol. The synergistic effect of cedar plant ethanol extract was high.

8) The effective rate of hair growth and wool promoters containing 2.0% of Yeonmyeongcho extract (corresponding to 2 g of dry weight), 2.0% of red ginseng extract (corresponding to 2g of dry weight) and 0.2% of cedar plant ethanol extract The synergistic effect of the cedar plant ethanol extract was 6.9% higher than that of 2.0% (corresponding to 2 g of dry weight) of the extract of Myeongchocho vinegar.

The composition of each base used in the manufacture of the hair growth and wool promoter used in the test is as follows.

Mechanism 1

Base 2

Base 3

Claims (7)

An external preparation for skin, comprising a cedar plant extract as an essential ingredient. An external preparation for skin, comprising a compound known to be blended into a cedar plant extract and other external preparations on a skin external preparation base. The external preparation for skin according to claim 1 or 2, wherein the arrowhead plant is an arrowhead, evergreen or succulent. The external preparation for skin according to claim 1 or 2, which is a hair growth / wool agent. The method according to claim 1 or 2, wherein the extract of the rhododendron plants contains 0.001 to 10% (w / w), preferably 0.01 to 5% (w / w) in weight (w) in terms of dry solids. Skin external preparation, characterized in that. 3. A component according to claim 2, wherein the component known to be blended into the external preparation is (3-carboxypropyl) -trimethylammonium chloride methyl ester, 6-amino-1,2-dihydrohydroxyimino-4-piperidinopyrimidine, 7-chloro-3-methyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide, polyoxyethylene sorbitan monostearate (20 EO), early spring extract of gentian, ethynyl An external preparation for skin, characterized in that it is one or two or more substances selected from the group consisting of estradiol, extract, and ginseng extract. The external preparation for skin according to claim 1 or 2, which is a liquid, a cream, a gel cream, an ointment or a solid.