JPH05139938A - Hair producing and growing agent - Google Patents

Abstract

PURPOSE:To obtain a hair producing and growing agent having excellent hair producing and growing effects, showing safety and stability sufficiently standing long-term use. CONSTITUTION:The whole amount of a hair producing and growing agent is blended with 0.001-10wt.%, especially 0.05-5wt.% calculated as an essence of an extract obtained by extracting Vitex cannabifolia or Vitex negundo with water and/or a water-soluble organic solvent, preferably an extract (extracted solution or essence) obtained by extracting the whole plant, preferably seed of Vitex cannabifolia or Vitex negundo with water and/or a water-soluble in the presence of solvent as a hair producing and promoting component to give a hair producing and growing agent having the above-mentioned effects. The extract is estimated to irritate hair roots, to promote blood circulation around hair follicle, to activate metabolism and to improve hair production and growth.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair-growth / hair-growth agent, and more particularly, to a hair-growth / hair-growth that has excellent hair-growth / hair-growth effects and is highly safe and stable enough to withstand long-term use It is intended to provide a fee.

[0002]

2. Description of the Related Art At present, various herbal medicine extracts or various compounds are blended in the hair growth and hair growth materials provided. For example, as a crude drug extract, Yokuinin, Ginkgo biloba, Kashi, etc.
Japanese Patent Laid-Open No. 2-48512 and Japanese Patent Laid-Open No. 2-48
No. 514, etc.), and the compound is vitamin E,
Alloxazine, pyridine N-oxide, adenosine-
3 ', 5'-cyclic monophosphate
4-56608, JP-A-1-261321, JP-A-2-204406) and the like.

[0003]

DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention However, as described in the above examples, the hair-growth / hair-growth agents provided so far are as follows:
Various crude drug extracts and various compounds have been applied, but few have significant effects.
Those having a certain degree of effect had drawbacks such as strong irritation to cause dermatitis and difficulty in continuous use. Therefore, it was an object to develop a hair-growth / hair-growth material having excellent hair growth / hair-growth effects and safety and stability that can sufficiently withstand long-term use.

[0004]

As a result of earnest research to solve the above problems, the present inventors have found that
An extract obtained by extracting gundo L. var. cannabifolia: Chinese name oyster) or Chinese carrot (Vitex negundo L .: yellow peach) with water and / or water-soluble organic solvent is effective for hair growth and hair growth Therefore, they have found that the above problems can be solved, and have reached the present invention.

[0005] That is, the present invention is characterized in that it contains an extract obtained by extracting carrots or carrots with water and / or a water-soluble organic solvent as a hair growth / hair growth promoting component. It is a hair-growth agent, and in a preferred embodiment, the content of the extract is 0.001 to 10% by weight as an extract.

The present invention will be described in detail below.

[0007] The carrots used in the present invention are plants of the family Vine family, Vitex negundo L.var.cannabifolia.
The Chinese name is called oyster, and the origin is mainly in the Indian region. In addition, the Taiwan carrot Boku is also a plant of the family Nepenthes, called Vitex negundo L., and the Chinese name is Yongjiang. The fruits of these plants are mainly used to treat the common cold, and the root juice is used as an expectorant.
No examples of verifying the hair-growth / hair-growth effects of these plants have been found, and the present inventors have first found out.

The water-soluble organic solvent applied to the present invention is
Examples thereof include primary alcohols such as methanol, ethanol, propanol and butanol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, and water-soluble organic solvents such as acetone, tetrahydrofuran and dioxane, which may be used alone or as a mixed solvent.

[0009] Next, a general method for producing an extract having a hair growth and hair growth promoting effect from carrots or carrots will be described. A suitable method is a method in which whole plants of carrots or carrots, preferably seeds, are subjected to digestion extraction with water and / or a water-soluble organic solvent. A general extraction procedure is to use 0.5 to 5 liters of a solvent for 100 g of carrot or 100 g of ginseng at room temperature to the boiling point of the extraction solvent at room temperature.
It is digested and extracted once or twice for 10 days during heating for 4 to 8 hours. The extracts are combined, filtered with suction, and concentrated under reduced pressure to remove the solvent to obtain a viscous or dry extract. These extracts (extracts or extracts) are used as they are or after being dissolved, dispersed and diluted with an appropriate solvent or the like.

[0010] Next, a concrete example of the production of the carrot-boiled or carrot extract extracted from the carrot used in the examples is shown. (1) 100 g of carrot seeds were soaked and extracted with 1 liter of 70% ethanol water at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 10%. , Hereinafter referred to as Extract A). (2) 100 g of the whole grass carrots are dipped in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 7%, hereinafter referred to as extract B). (3) 100 g of the seeds of Ginseng japonicus are immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 12%, hereinafter referred to as extract C). (4) 100 g of the whole carrot plant is immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 8.5%, hereinafter referred to as extract D). (5) 100 g of carrot seeds are immersed in 1 liter of an extraction solvent of 1,3-butylene glycol: distilled water = 1: 1, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. After cooling, the residue is filtered off with filter paper, and the filtrate is evaporated to obtain a viscous extract (yield 8.5%,
Hereinafter referred to as extract E). (6) 100 g of the whole plant of Ginseng japonicus was soaked and extracted with 1 liter of water at room temperature for 10 days, the residue was filtered off with a filter paper, and the filtrate was evaporated to obtain a viscous extract (yield 7.8. %, Hereinafter referred to as extract F).

[0011] The content of the extract of carrot or the carrot scented as the active ingredient for promoting hair growth and hair growth according to the present invention is preferably 0.001 to 10% by weight based on the total amount of hair growth and hair growth material. , And more preferably 0.05 to 5% by weight. Content is 0.001% by weight
A lower concentration does not show a sufficient hair-growth effect in the hair-growth test described below, and a concentration higher than 10% by weight is not preferable because the stability of the hair-growth / hair-growth material itself becomes poor.

Other raw material components applied to the hair-growth / hair-growth composition of the present invention include hydrocarbons, waxes, oils / fats, esters, higher fatty acids, and higher-grade materials generally applied to hair-growth / growth compositions. Alcohols, surfactants, fragrances, pigments, preservatives, antioxidants, UV protectors, alcohols, pH adjusters, and medicinal ingredients suitable for the purpose of the present invention are appropriately selected and prepared. Further, it can be used in combination with a publicly known and publicly used hair growth / hair growth ingredient. Further, the hair growth and hair-growth agent of the present invention includes various dosage forms such as hair tonic, hair lotion, hair treatment, hair cream, shampoo, rinse,
Pomade and so on.

[0013]

[Function] The hair growth and hair-restoring agent of the present invention is one in which an extract of carrot or swan carrot stimulates hair roots, stimulates blood circulation around hair follicles, activates metabolism, and promotes hair growth and hair growth. I guess.

[0014]

Example First, the effect of the extract on hair growth in mice is tested.

<Experimental Method and Results> (1) Specimen Containing 5% of ethanol extract extract from carrots or carrots applied to the present invention 7
A 0% ethanol aqueous dispersion, a 70% ethanol aqueous dispersion containing 1% of vitamin E, which has been conventionally known as a component having hair growth and hair-growth effects, and a control,
Four specimens of 70% aqueous ethanol solution of the solvent were used. (2) Hair Growth Test Method Using Mice This test method uses 9-week-old C3H mice to make 4 groups, each group having 10 mice, and 2.0 × 2.0 of the backs thereof.
After removing hair, remove the sample 0.04 the day after removing the
On the 16th day after application of g, the density of hair growth at the site was captured as the degree of increase in black (decrease in L value) using a color difference meter.

(3) Effect

[Table 1] As is clear from Table 1, in the 70% ethanol aqueous dispersion containing the extract of Ginseng radix or Ginseng radix extract applied to the present invention, L value was decreased and black color was increased. It can be seen that the effect is remarkable. On the other hand, 70% containing conventional vitamin E
It can be seen that the effect of promoting hair growth is weak in the ethanol aqueous dispersion since the decrease in L value is small. It is speculated that this is the result of the carrot box or the Chinese carrot extract of the present invention stimulating the hair root, making blood circulation around the hair follicle more active, and activating metabolism.

Hereinafter, the hair-growth / hair-growth material of the present invention will be described with reference to Examples, but the present invention is not limited to these Examples. The blending amount is parts by weight.

Hair tonics of Examples 1, 2, 3 and Comparative Example 1 (prescription)

[Table 2]

(Manufacturing method) Each raw material is placed in a stirring container equipped with a heating device, heated and mixed at 50 ° C. for dissolution to be solubilized to obtain a product.

Next, in order to confirm that the hair growth and hair-growing effect of the product of the present invention is remarkable, an actual use test for humans is conducted.

<Experimental Method and Results> (1) Sample Hair Tonics of Examples 1, 2, 3 and Comparative Example 1 (2) Test Method Four groups of 20 panelists, each having 20 panelists who complain of thinning hair and alopecia. Then, a hair growth / hair-growth effect test was carried out by using each sample for 6 consecutive months in each group. As a method of use, a method of evenly applying to the head twice a day was used as in the normal tonic method. The evaluation was performed 3 months and 6 months after the start of use, and the extent to which the number of subjects who felt that the vellus hair and vellus had increased increased was measured. At the end of the test, they were also asked to improve their scalp and reduce the occurrence of dandruff.

(3) Result

[Table 3] As is clear from Table 3, in the hair tonics of Examples 1, 2, and 3 containing the carrot extract of the present invention,
The hair-growth effect was recognized because the number of people with downy hairs and those with terminal hairs increased. On the other hand, it was found that the effect was not detected in the hair tonic of Comparative Example 1 containing no carrot extract. At the end of the test, the number of persons who reported improvement in scalp condition and reduction of dandruff in Example 1 was 3 and in Example 2 was 1.
From this, it is confirmed that the hair tonic containing the carrot extract of the present invention also has a remarkable hair growth effect. Furthermore, during the use test period, no skin damage such as deterioration of the scalp condition or inflammatory reaction was observed in any of the panelists, confirming that the product of the present invention has high safety. All hair tonics were stable.

Example 4 Hair lotion (prescription)

[Table 4] (Manufacturing method) The compounded raw materials of Group A and the compounded raw materials of Group B in Table 4 are separately stirred at room temperature to be homogeneously dissolved. The raw material solution of B is added to the raw material solution of A, and C is further added to obtain a product.

Example 5 Hair Treatment (Prescription)

[Table 5] (Manufacturing method) The compounded raw materials of Group A and the compounded raw materials of Group B in Table 5 are separately stirred at 80 ° C. to be homogeneously dissolved. The solution of A is added to the solution of B and emulsified. Cool to 40 ° C. with stirring, add C and then D to obtain a product.

Example 6 Hair Cream (Formulation)

[Table 6] (Manufacturing method) The mixed raw materials of the A group in Table 6 are mixed and dissolved at 80 ° C., and then the solution of A is gradually added to the solution of B previously heated and dissolved at 80 ° C. to emulsify. Then, it cools to 40 degreeC, D is added, and it is set as a product.

Example 7 Shampoo (prescription)

[Table 7] (Production method) The raw materials of Group A in Table 7 are mixed at 80 ° C,
After that, it is cooled to 40 ° C., the solution of B is added, and further C is added to obtain a product.

[0027]

EFFECT OF THE INVENTION The hair growth and hair-growth agent containing the carrot or the extract of Ginseng japonicus of the present invention has a hair-growth effect in a hair-growth test using mice, and further has a hair-growth effect in an actual use test for human. A hair growth effect was observed, and no skin damage due to long-term continuous use was observed.

Continued Front Page (72) Inventor, Koichiro Yoshihama, 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture, Yokohama Research Laboratories, Pola Chemical Industry Co., Ltd. (72) Hideo Kuroda, 27, Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Kasei Kogyo Co., Ltd. Yokohama Research Center (72) Inventor Masami Suzuki 1 Takashimadai 27-1 Takashimadai, Kanagawa-ku, Kanagawa Yokohama

Claims (2)

[Claims] 1. A hair-growth / hair-growth agent, which comprises an extract obtained by extracting carrot or Ginseng japonicus with water and / or a water-soluble organic solvent as a hair-growth / hair-growth promoting component. 2. The hair growth and hair restoration material according to claim 1, wherein the content of the extract is 0.001 to 10% by weight as an extract.