JP4557582B2 - Anti-itch agent - Google Patents
Anti-itch agent Download PDFInfo
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- JP4557582B2 JP4557582B2 JP2004098164A JP2004098164A JP4557582B2 JP 4557582 B2 JP4557582 B2 JP 4557582B2 JP 2004098164 A JP2004098164 A JP 2004098164A JP 2004098164 A JP2004098164 A JP 2004098164A JP 4557582 B2 JP4557582 B2 JP 4557582B2
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- Prior art keywords
- itch
- agent
- extract
- basil
- analgesic
- Prior art date
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- 208000003251 Pruritus Diseases 0.000 title claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 240000001592 Amaranthus caudatus Species 0.000 claims description 4
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 230000007803 itching Effects 0.000 claims 1
- 241001529734 Ocimum Species 0.000 description 10
- 239000000419 plant extract Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 241000196324 Embryophyta Species 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 235000010676 Ocimum basilicum Nutrition 0.000 description 8
- 230000000202 analgesic effect Effects 0.000 description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- -1 methyl ethyl ketone Alkyl ethers Chemical class 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 241000282421 Canidae Species 0.000 description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 229920002055 compound 48/80 Polymers 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 241000207965 Acanthaceae Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 2
- 241000207984 Justicia Species 0.000 description 2
- 240000000084 Justicia gendarussa Species 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N Methyl ethyl ketone Natural products CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 241001184073 Basilicum Species 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 235000011205 Ocimum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229940124513 senna glycoside Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本発明は、有効成分として植物の抽出液を含有することを特徴とする鎮痛剤及び抗かゆみ剤に関する。さらに、詳しくは、キツネノマゴ、バジル、ハナセンナから選ばれる1種以上の植物の抽出液を含有することを特徴とする鎮痛剤及び抗かゆみ剤に関する。 The present invention relates to an analgesic and an anti-itch agent characterized by containing a plant extract as an active ingredient. More particularly, the present invention relates to an analgesic and an anti-itch agent characterized by containing an extract of one or more kinds of plants selected from foxes, basil, and hanasenna.
有効成分として植物抽出液を含有することを特徴とした鎮痛剤及び抗かゆみ剤はいくつか挙げられるが、これまでに知られているものでキツネノマゴ、ハナセンナを含むものはない。 There are several analgesics and anti-itch agents characterized by containing a plant extract as an active ingredient, but there are none known so far, including none of foxes and hanasenna.
これまでに知られている鎮痛剤及び抗かゆみ剤で、バジルを含む例があるが（特許文献1）、香料の具体例としてバジルの記載及びバジルに健胃、食欲増進作用が知られているという記載はあるが、バジルの鎮痛作用及び抗かゆみ作用については言及しておらず、バジルに鎮痛作用及び抗かゆみ作用を期待した外用剤に関するものではない。 There is an example of an analgesic agent and an anti-itch agent known so far, including basil (Patent Document 1), but as a specific example of a fragrance, description of basil and a healthy stomach and an appetite enhancing action are known. However, there is no mention of the analgesic action and anti-itch action of basil, and it does not relate to an external preparation that expected basil to have an analgesic action and anti-itch action.
鎮痛作用及び抗かゆみ作用を有する植物由来成分を含有させた新規で安全な皮膚外用鎮痛剤、皮膚外用抗かゆみ剤、更に化粧料を提供することを課題とする。 It is an object of the present invention to provide a novel and safe external skin pain relieving agent, a skin external anti-itch agent, and a cosmetic that contain a plant-derived component having analgesic activity and anti-itch activity.
キツネノマゴ科(Acanthaceae)のキツネノマゴ(Justicia
gendarussa )、シソ科(Labiatae)のバジル(Ocimum
basilicum )、マメ科(Leguminosae)のハナセンナ(Cassia
alata )から選ばれる1種以上の植物の抽出液を応用することにより新規で安全な皮膚外用鎮痛剤、皮膚外用抗かゆみ剤、更に化粧料を提供することができる。
Acanthaceae foxtail (Justicia)
gendarussa), Labiatae basil (Ocimum)
basilicum), leguminosae legumes (Cassia)
By applying an extract of one or more plants selected from alata), it is possible to provide a new and safe skin external pain relieving agent, skin external anti-itch agent, and cosmetics.
キツネノマゴ、バジル、ハナセンナのから選ばれる1種以上植物抽出液を配合することで安全性が高く、高い鎮痛効果および抗かゆみ効果を得ることが出来る。 By blending one or more plant extracts selected from foxes, basil, and hanasenna, it is highly safe and can provide high analgesic and anti-itching effects.
本発明に用いられる植物抽出液の抽出部位は特に限定されない。葉、花、茎、根、全草を用いることが出来るが，キツネノマゴは全草、バジルは全草、ハナセンナは葉が好適に用いることが出来る。 The extraction site | part of the plant extract used for this invention is not specifically limited. Leaves, flowers, stems, roots, and whole plants can be used, but foxes can be used as whole plants, basil as whole plants, and hanasenna as leaves.
抽出溶媒としては、特に限定はされないが例えば、水；メチルアルコール、エチルアルコール等の低級１価アルコール；グリセリン、プロピレングリコール、1,3-ブチレングリコール等の液状多価アルコール；アセトン、メチルエチルケトン等のケトン；酢酸エチルなどのアルキルエステル；ベンゼン、ヘキサン等の炭化水素；ジエチルエーテル等のエーテル類；ジクロルメタン、クロロホルム等のハロゲン化アルカン等の１種または２種以上を用いることが出来る。水、エチルアルコール、1,3-ブチレングリコールの１種または２種以上の混合溶媒が好適に用いられるが、中でも水抽出が最適である。 The extraction solvent is not particularly limited. For example, water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; ketones such as acetone and methyl ethyl ketone Alkyl ethers such as ethyl acetate; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; halogenated alkanes such as dichloromethane and chloroform; One or two or more mixed solvents of water, ethyl alcohol, and 1,3-butylene glycol are preferably used, and water extraction is most preferable.
本発明に用いる植物抽出物は、生のままあるいは乾燥した植物体を重量比で１〜1000倍量、特に10〜100倍量の溶媒を用い、０℃以上、特に２０℃〜４０℃で１時間以上、特に３〜７日間行うのが好ましい。 The plant extract used in the present invention is 1 to 1000 times by weight, particularly 10 to 100 times as much solvent as a raw or dried plant body, and is 0 ° C. or more, particularly 1 to 20 ° C. to 40 ° C. It is preferable to carry out for more than time, especially 3-7 days.
以上のような条件で得られる植物抽出液は、抽出された溶液のまま用いても良いが、さらに必要により濾過等の処理をして、濃縮、粉末化したものを適宜使い分けて用いることが出来る。
The plant extract obtained under the above conditions may be used as an extracted solution, but if necessary, it can be used by appropriately filtering and concentrating and pulverizing by filtration or the like. .
本発明における植物抽出液の配合量は、有効量含有されれば良いのであるが、鎮痛剤、抗かゆみ剤及びそれらを配合した皮膚外用剤又は化粧料における配合量は、蒸発乾燥分に換算して一般的に0.0001〜30.0重量%が好ましく、特に0.01〜10.0重量%の範囲が最適である。含有量が0.0001重量%未満であると充分な効果が発揮されない場合があり、30.0重量%以上加えても効果はほぼ一定である。
The blending amount of the plant extract in the present invention should be contained in an effective amount. However, the blending amount in the analgesic agent, the anti-itch agent and the external preparation for skin or cosmetics blended with them is converted into the amount of evaporated dry matter. In general, 0.0001 to 30.0% by weight is preferable, and the range of 0.01 to 10.0% by weight is particularly optimal. If the content is less than 0.0001% by weight, a sufficient effect may not be exhibited, and the effect is almost constant even when added in an amount of 30.0% by weight or more.
上記必須成分のほか、水性成分、油性成分、植物抽出物、動物抽出物、粉末、賦形剤、界面活性剤、油剤、アルコール、ｐＨ調整剤、防腐剤、酸化防止剤、増粘剤、色素、香料等を必要に応じて混合して適宜配合することにより調製される。また、剤型は特に限定されず、化粧水、乳液、クリーム、パック、パウダー、スプレー、軟膏、分散液、洗浄料、および液体状、ペースト状、カプセル状、粉末状、錠剤、注射液等種々の剤型とすることができる。
In addition to the above essential components, aqueous components, oil components, plant extracts, animal extracts, powders, excipients, surfactants, oil agents, alcohol, pH adjusters, preservatives, antioxidants, thickeners, pigments It is prepared by mixing fragrances and the like as necessary and blending them appropriately. The dosage form is not particularly limited, and various types such as lotion, emulsion, cream, pack, powder, spray, ointment, dispersion, cleaning agent, liquid, paste, capsule, powder, tablet, injection, etc. It can be made into the dosage form.
以下、実施例を挙げて、本発明を具体的に説明するが、本発明は何ら実施例に限局されるものではない。 Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to the examples.
キツネノマゴ科(Acanthaceae)のキツネノマゴ(Justicia
gendarussa )全草を乾燥させ、その200gを60℃の水2リットルに4時間浸漬し、ろ過して抽出液を得た。
Acanthaceae foxtail (Justicia)
gendarussa) whole plant was dried, 200 g of it was immersed in 2 liters of water at 60 ° C. for 4 hours and filtered to obtain an extract.
実施例1に準じて、シソ科(Labiatae)のバジル(Ocimum
basilicum )全草より抽出液を得た。
According to Example 1, Labiatae basil (Ocimum
basilicum) The extract was obtained from the whole plant.
実施例1に準じて、マメ科(Leguminosae)のハナセンナ(Cassia
alata )の葉より抽出液を得た。
According to Example 1, Legassinosae (Cassia)
The extract was obtained from the leaves of alata).
試験例1： ICR系マウスにおいてcompound 48/80 皮下投与により引っ掻き行動(スクラッチング)を誘発し、その行動を抑制する能力を測定することにより抗かゆみ作用を評価した。植物抽出液はcompound 48/80を投与する30分前に皮下投与した。スクラッチングはcompound 48/80投与後30分間にみられた回数を測定した。 Test Example 1: Scratching behavior was induced by subcutaneous administration of compound 48/80 in ICR mice, and the anti-itch action was evaluated by measuring the ability to suppress the behavior. The plant extract was administered subcutaneously 30 minutes before compound 48/80 was administered. The number of scratching was observed 30 minutes after compound 48/80 administration.
実施例1、実施例2、実施例3の各処置群とも生理食塩水処置群との間に統計学的に有意な差がみとめられた。 Each treatment group of Example 1, Example 2, and Example 3 was found to have a statistically significant difference from the saline treatment group.
試験例2 ICR系マウスにおいてacetic acid 腹腔内投与により苦悶反応(ライジング)を誘発し、その反応を抑制する能力を測定することにより鎮痛作用を評価した。植物抽出液はacetic acidを投与する30分前に皮下投与した。ライジングはacetic acid投与後30分間にみられた回数を測定した。 Test Example 2 In an ICR mouse, acetic acid was induced by intraperitoneal administration, and an analgesic action was evaluated by measuring the ability to suppress the reaction. The plant extract was administered subcutaneously 30 minutes before the administration of acetic acid. Rising was measured the number of times seen 30 minutes after acetic acid administration.
実施例1、実施例2、実施例3の各処置群とも生理食塩水処置群との間に統計学的に有意な差が認められた。 A statistically significant difference was recognized between each of the treatment groups of Example 1, Example 2, and Example 3 and the physiological saline treatment group.
表１、表２に示したとおり、実施例1、実施例2、実施例3とも抗かゆみ作用及び鎮痛作用を認めた。 As shown in Tables 1 and 2, anti-itch action and analgesic action were observed in Example 1, Example 2 and Example 3.
これらの効果は、皮下投与のみではなく、経皮投与においても同様に認められた。 These effects were similarly observed not only by subcutaneous administration but also by transdermal administration.
下記に処方例を示す。本発明はこれら処方例に何等限定されるものではない。尚、処方例における数値は重量部を表す。 A prescription example is shown below. The present invention is not limited to these formulation examples. In addition, the numerical value in a prescription example represents a weight part.
処方例１：化粧水
a)1,3 ブチレングリコール・・・6
b)グリセリン・・・4
c)ポリオキシエチレン（20）ソルビタンモノラウリン酸エステル・・・0.5
d)ポリオキシエチレン（15）ラウリルアルコールエーテル・・・0.5
e)メチルパラベン・・・0.1
f)エタノール・・・5
g)ハナセンナ水抽出液・・・3
h)精製水・・・80.9
＜製法＞
h)にa),b),g)を溶解して水相とした。F)にc),d),e)を溶解し、先の水相に混合可溶化した後、ろ過し、化粧水を得た。
Formulation Example 1: Lotion
a) 1,3 Butylene glycol ・ ・ ・ 6
b) Glycerin ... 4
c) Polyoxyethylene (20) sorbitan monolaurate ester ... 0.5
d) Polyoxyethylene (15) lauryl alcohol ether 0.5
e) Methyl paraben ... 0.1
f) Ethanol ... 5
g) Hana-senna water extract ... 3
h) Purified water ... 80.9
<Production method>
A), b) and g) were dissolved in h) to obtain an aqueous phase. C), d) and e) were dissolved in F), mixed and solubilized in the previous aqueous phase, and then filtered to obtain a lotion.
処方例２：軟膏
a)ポリオキシエチレン硬化ヒマシ油(60E.O.)・・・10.0
ｂ)ポリオキシエチレンセチルエーテル(2E.O.)・・・ 10.0
c)ステアリルアルコール・・・10.0
d)プロピレングリコール・・・30.0
e)グリセリン・・・36.9
f)キツネノマゴ・・・3.0
g)エチルパラベン・・・0.1
＜製法＞
a)〜g)を加熱溶解し、35℃まで攪拌しながら冷却する。
Formulation Example 2: Ointment
a) Polyoxyethylene hydrogenated castor oil (60E.O.) ... 10.0
b) Polyoxyethylene cetyl ether (2E.O.) ... 10.0
c) Stearyl alcohol ... 10.0
d) Propylene glycol ... 30.0
e) Glycerin ... 36.9
f) Foxtail ... 3.0
g) Ethylparaben ... 0.1
<Production method>
a) to g) are heated and dissolved and cooled to 35 ° C. with stirring.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004098164A JP4557582B2 (en) | 2004-03-30 | 2004-03-30 | Anti-itch agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004098164A JP4557582B2 (en) | 2004-03-30 | 2004-03-30 | Anti-itch agent |
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| JP2005281206A JP2005281206A (en) | 2005-10-13 |
| JP4557582B2 true JP4557582B2 (en) | 2010-10-06 |
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| JP5925028B2 (en) * | 2011-09-01 | 2016-05-25 | 花王株式会社 | Skin lightening agent |
| WO2014034802A1 (en) | 2012-08-29 | 2014-03-06 | 花王株式会社 | Transglutaminase activator |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000027351A1 (en) * | 1998-11-10 | 2000-05-18 | L'oreal | Use of at least a genus ocimum plant extract |
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| JP3118020B2 (en) * | 1991-05-13 | 2000-12-18 | 有限会社野々川商事 | Cosmetics |
| US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
| JP2004517838A (en) * | 2000-12-15 | 2004-06-17 | ファルマシア・コーポレーション | Selective COX-2 inhibition by non-edible plant extracts |
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| WO2000027351A1 (en) * | 1998-11-10 | 2000-05-18 | L'oreal | Use of at least a genus ocimum plant extract |
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