KR102289620B1 - Cosmetic composition comprising extracts of myosotis sylvatica and extracts of nymphaea tetragona georgi for moisturizing the skin - Google Patents

Abstract

The present invention relates to a cosmetic composition that is hypoallergenic and has a remarkably excellent moisturizing effect on skin by containing a Myosotis extract and a Nymphaea extract as active ingredients.

Description

COSMETIC COMPOSITION COMPRISING EXTRACTS OF MYOSOTIS SYLVATICA AND EXTRACTS OF NYMPHAEA TETRAGONA GEORGI FOR MOISTURIZING THE SKIN, which includes a forget-me-not extract and water lily extract as active ingredients

The present invention relates to a cosmetic composition for moisturizing the skin comprising a forget-me-not extract and water lily extract as active ingredients.

The skin consists of the epidermis, dermis, and subcutaneous tissue, and performs various functions to protect the body from various external stimuli. In particular, the skin develops a thin stratum corneum containing water on the outer surface of the epidermis to prevent water loss. The stratum corneum is the outermost layer of the skin that comes into contact with the external environment, and prevents the intrusion of harmful ingredients while preventing the loss of moisture inside the skin so that the moisture of the skin is maintained at an appropriate level.

On the other hand, when the moisture of the skin is not maintained at an appropriate level, skin elasticity and flexibility are lowered, and skin diseases such as dry skin, atopy, psoriasis, and eczema occur while the skin aging rapidly progresses. In addition, when the moisture of the skin is lowered, the cosmetic composition does not sufficiently adhere to the skin during makeup, and thus there is a problem that the durability of the makeup is reduced, and various efforts are being made to maintain the moisture of the skin at an appropriate level.

Specifically, as the moisture of the skin decreases or decreases due to external factors such as ultraviolet rays, wind, dust, temperature, and internal factors such as aging, hormonal imbalance, and stress, the above external factors and internal factors are solved, Various attempts are being made to give the skin a sense of moisture.

In particular, in recent years, various attempts have been made to provide a feeling of moisture to the skin while being hypoallergenic, including extracts extracted from natural materials. For example, Korean Patent Registration No. 10-2043444 discloses a cosmetic composition for moisturizing the skin comprising an extract of chamomile jabanum.

On the other hand, forget-me-not is known to be used to prevent or improve diseases such as colds, nosebleeds, respiratory diseases, chest pain, etc., and is rich in minerals and vitamins and is known to be effective in skin beauty.

In addition, in the case of water lily ( Nymphaea tetragona Georgi ), the leaves and roots contain amino acids and alkaloids, and the seeds contain starch, protein, fat, etc. It is known to be effective in lowering blood pressure, obesity and hyperlipidemia. For example, Korean Patent Application Laid-Open No. 10-2013-0064034 discloses a pharmaceutical composition for preventing and treating metabolic diseases containing water lily root extract as an active ingredient.

As described above, forget-me-not plants and water lilies are used for the prevention, improvement or treatment of various diseases, but it can be seen that their utility is insignificant for the purpose of realizing the moisturizing effect of the skin.

Accordingly, the present applicant completed the present invention by developing a cosmetic composition having excellent skin moisturizing effect while being hypoallergenic to the skin, including extracts obtained from natural materials including forget-me-not and water lily, which had low utility for skin moisturizing purposes. did.

Republic of Korea Patent Registration No. 10-2043444 Republic of Korea Patent Publication No. 10-2013-0064034

An object of the present invention is to provide a cosmetic composition using an extract of forget-me-not and water lily, which is hypoallergenic to the skin and has a remarkably excellent skin moisturizing effect.

The object of the present invention is not limited to the technical problem as described above, and another technical problem may be derived from the following description.

In order to achieve the above object, the present invention provides a cosmetic composition for moisturizing the skin, comprising the Forget-me-not ( Myosotis sylvatica ) extract and the water lily ( Nymphaea tetragona Georgi ) extract as active ingredients.

The cosmetic composition may include the forget-me-not extract and water lily extract in a weight ratio of 1: 0.1 to 5.

The cosmetic composition may include 0.0001 to 10% by weight of the forget-me-not extract and water lily extract based on the total weight of the cosmetic composition.

The forget-me-not extract and water lily extract are selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, dichloromethane, ethyl ether, hexane and 1,3-butylene glycol. It may be extracted with an extraction solvent containing one or more.

The cosmetic composition is selected from the group consisting of softening lotion, nourishing lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water. It may be of any one formulation.

The cosmetic composition of the present invention may contain extracts of forget-me-not and water lily, which are natural materials, so that the skin moisturizing effect is remarkably excellent while being hypoallergenic to the skin.

In particular, the cosmetic composition of the present invention can be safe for the skin while realizing a significantly superior skin moisturizing effect than when each of the Forget-me-not-leaf extract or the water-lily extract is included alone by including the Forget-me-not-leaf extract and the water lily extract together.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily implement them. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein. And in order to clearly explain the present invention in the drawings, parts irrelevant to the description are omitted.

The terms or words used in the specification and claims of the present invention are not to be construed as limited in their ordinary or dictionary meanings, and the inventor may appropriately define the concept of the term in order to best describe his invention. Based on the principle, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

In the entire specification of the present invention, when a part "includes" a certain component, it means that other components may be further included, rather than excluding other components unless otherwise stated. .

Throughout the specification of the present invention, "A and/or B" means A or B, or A and B.

Although the present invention has been specifically described below, the present invention is not limited thereto.

The present invention provides a cosmetic composition for moisturizing the skin.

In one embodiment of the present invention, as it contains a forget-me-not extract and water lily (Nymphaea tetragona Georgi ) extract as active ingredients, it provides a cosmetic composition that is hypoallergenic and has a remarkably excellent moisturizing effect on the skin.

Specifically, the cosmetic composition of this embodiment includes the Forget-me-not-leaf extract and the water lily extract together, so that a superior skin moisturizing effect can be realized than when each of the Forget-me-not and water lily extract is included alone.

In particular, the cosmetic composition of this embodiment includes both a forget-me-not extract and a water lily extract, but by including the two types of extracts in a specific ratio, if one of the two types of extracts is included, or the two types of extracts are used in this embodiment It is possible to implement a significantly superior skin moisturizing effect than when it is included in a mixing ratio other than those presented in the example.

Forget-me-not is a perennial plant of the dicotyledonous family Lamiaceae, the origin of which is Europe, and is mainly used for ornamental purposes. Forget-me-not plants have many hairs throughout, and the leaves gathered from the roots are in the shape of an upside down lancet, have petioles, but the leaves on the stem do not have petioles, are formed in a long oval shape, and the flowers bloom in raceme in May to June. .

Specifically, the forget-me-not is a perennial grass of the family Lamiaceae, dicotyledonous, and may refer to Myosotis sylvatica.

Forget-me-not plants are known to be used to prevent or improve diseases such as colds, nosebleeds, respiratory diseases, and chest pain, and are rich in minerals and vitamins and are known to be effective in skin care.

The Forget-me-not extract is an extract obtained by extraction treatment of Forget-me-not-forget-me-not, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, such as the extract itself and the extract. Extracts of all formable formulations are included. Specifically, the forget-me-not extract of this embodiment may be prepared in the form of a dry powder after extraction, but is not limited thereto.

The extraction of the Forget-me-not may be performed by any known method, for example, hot water extraction, ethanol extraction, microwave extraction, supercritical extraction and ultrasonic extraction to be performed by any one method selected from the group consisting of can, but is not limited thereto.

In the forget-me-not extract of this embodiment, the extraction site of Forget-me-not may be a site or outpost including one or more selected from the group consisting of flowers, roots, leaves and stems. Specifically, in the forget-me-not extract of this embodiment, the extraction part of the forget-me-not may include flowers, leaves and stems, but is not limited thereto.

Forget-me-not extract of this embodiment is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, dichloromethane, ethyl ether, hexane and 1,3-butylene glycol It may mean extraction with an extraction solvent containing at least one.

Specifically, the Forget-me-not extract may be obtained by extracting ethanol as an extraction solvent.

More specifically, the Forget-me-not extract may be obtained by extracting 70% (v/v) ethanol as an extraction solvent.

The water lily ( Nymphaea tetragona Georgi ) is a perennial aquatic plant of the water lily family, and is mainly grown for ornamental purposes in swamps and ponds south of the central Korean peninsula. Water lilies have hard petioles and peduncles from rhizomes that have fallen into the mud in shallow water, and round, split leaves protruding toward the center float on the water. Flowers bloom from June to August on the surface of the water, and the flowers are folded at night.

This water lily ( Nymphaea tetragona Georgi ) contains amino acids, alkaloids, starch, protein, fat, etc., and is known to be effective in lowering blood pressure, obesity and hyperlipidemia, and is also used as a pharmaceutical composition for preventing and treating metabolic diseases. .

The water lily extract is an extract obtained by extraction treatment of water lily, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, using the extract itself and the extract. Extracts of all formable formulations are included. Specifically, the water lily extract of this embodiment may be prepared in the form of a dry powder after extraction, but is not limited thereto.

The extraction of the water lily may be performed by any known method, for example, hot water extraction, ethanol extraction, microwave extraction, supercritical extraction, and ultrasonic extraction to be performed by any one method selected from the group consisting of can, but is not limited thereto.

In the water lily extract of this embodiment, the extraction part of the water lily may be a part or outpost including one or more selected from the group consisting of flowers, roots, leaves and stems. Specifically, in the water lily extract of this embodiment, the extraction part of the water lily may include flowers, leaves, and stems, but is not limited thereto.

The water lily extract of this embodiment is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, dichloromethane, ethyl ether, hexane and 1,3-butylene glycol It may mean extraction with an extraction solvent containing at least one.

Specifically, the water lily extract may be water extracted as an extraction solvent. More specifically, the water lily extract may be a hot water extract, and in this case, the water lily extract may implement an excellent skin moisturizing effect while being hypoallergenic to the skin.

The cosmetic composition of this embodiment includes the forget-me-not extract and water lily extract, and the two types of extracts may be included in a weight ratio of 1: 0.1 to 5. In particular, when the two types of extracts are included to satisfy the numerical range, the cosmetic composition of the present embodiment can realize a significantly improved skin moisturizing effect while being hypoallergenic to the skin.

Specifically, the cosmetic composition of this embodiment includes the forget-me-not extract and water lily extract, and the two types of extracts may be included in a weight ratio of 1: 1 to 3. In particular, when the two types of extracts are included to satisfy the numerical range, the cosmetic composition of the present embodiment can realize a remarkably excellent skin moisturizing effect while being hypoallergenic to the skin.

The cosmetic composition of this embodiment may include 0.0001 to 10% by weight, specifically 0.01 to 7% by weight, and more specifically 0.1 to 5% by weight of the Forget-me-not-leaf extract and water lily extract based on the total weight, but is not limited thereto. does not

When the cosmetic composition of this embodiment contains the forget-me-not-leaf extract and water lily extract in an amount of 0.0001 to 10% by weight, it is possible to provide a cosmetic composition that is hypoallergenic and has a remarkably excellent moisturizing effect on the skin.

The cosmetic composition of this embodiment contains the forget-me-not extract and water lily extract as active ingredients, along with dermatologically available excipients or additives, softening lotion, nourishing lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack , makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water may be formed in any one formulation selected from the group consisting of, but is not limited thereto, and may be formed in any known formulation.

At this time, the cosmetic composition of the present embodiment may be implemented in various formulations by further including an excipient or additive together with the Forget-me-not and water lily extract.

For example, the excipients or additives include surfactants, emulsifiers, emulsifying aids, silicone polymers, pigments, pigments, fragrances, preservatives, bactericides, oxidation stabilizers, organic solvents, thickeners, emollients, antioxidants, free radical scavengers, opacity Topical, stabilizer, emollient, antifoam, humectant, vitamin, insect repellent, preservative, anti-inflammatory, filler, polymer, propellant, basifying agent, acidifying agent, colorant, thickening agent, skin conditioning agent, whitening agent, antioxidant, anti-wrinkle and dissolving agent It may include one or more selected from the group consisting of topics, but is not limited thereto.

Hereinafter, through Examples, Comparative Examples, and Experimental Examples, the cosmetic composition including the Forget-me-not-leaf extract and the water lily extract of the present invention will be described in detail. These examples are only for illustrating the present invention, and therefore, the scope of the present invention should not be construed as being limited by these examples.

[ Manufacturing Example ]

Preparation Example 1: Preparation of forget-me-not extract

Forget-me-not ( Myosotis sylvatica ) Mix 1 kg of a mixture of flowers, leaves and stems and 10 L of purified water, heat until boiling, remove water and wash, and then add purified water 10 to 20 times, washed once again.

Then, the residue was air-dried, and about 70% ethanol was added in an amount 10 times the weight of the sample, followed by immersion at room temperature for 24 hours to separate the supernatant from the precipitate, followed by extraction three times. Then, using an 80 mesh sieve, the solid content of each extract was removed, then filtered again, concentrated using a reduced pressure concentrator, and then freeze-dried to obtain about 50 g of Forget-me-not-forget-me-not extract (solid content).

Preparation Example 2: Preparation of water lily extract

1 kg of a mixture of dried water lily ( Nymphaea tetragona Georgi ) flowers, leaves and stems and 10 L of purified water were mixed, boiled for 5 hours in an extractor equipped with a cooling condenser, and extracted, followed by filtration with a 300 mesh filter cloth. Then, after aging at 10 ~ 15 ℃ for 3 days, filtered with filter paper, concentrated using a vacuum concentrator in a distillation apparatus equipped with a cooling condenser, and then freeze-dried to obtain about 70 g of water lily extract (solid content) got it

[Example]

Examples 1 to 5

According to Table 1 [unit: wt%], a cosmetic composition (essence) comprising the Forget-me-not-leaf extract and water lily extract as active ingredients was prepared.

In this case, the Forget-me-not extract and water lily extract in Table 1 were mixed according to the mixing ratio of Table 2 [unit: weight ratio].

[ Comparative Example ]

Comparative Examples 1 to 4

It was prepared in the same manner as in Example 1, except that a cosmetic composition (essence) including an active ingredient (a mixture of forget-me-not-leaf extract and water lily extract) according to Table 3 [unit: weight ratio] was prepared.

In this case, '-' in Table 3 means that the corresponding component is not included.

[Experimental example]

Experimental Example 1: Evaluation of skin moisture increase rate

After selecting 20 to 40-year-old women with similar skin condition (moisture) and dividing them into groups (10 people each) according to Examples and Comparative Examples, the essence prepared according to Examples and Comparative Examples was applied to each group twice daily ( evening) and applied to the entire face for 15 days.

At this time, before applying the essence, measure the dryness of the skin using a moisture meter (corneometer, CM820 courage Khazaka electronic GmbHtk, Germany) under constant temperature and humidity conditions (24℃, 40% humidity) in advance, and then set this as a default value. , after 15 days have elapsed, the amount of skin moisture was measured, and the result of evaluating the amount of change is shown in Table 4 [unit: %].

Referring to Table 4, it can be seen that, according to the present example, the skin moisturizing effect is excellent.

Specifically, referring to Examples 1 to 5 and Comparative Examples 1 to 2, it can be seen that, according to this example, when both the Forget-me-not and water lily extracts are included, the skin moisturizing effect is remarkably improved.

In addition, looking at Examples 1 to 5 and Comparative Examples 3 to 4, it can be seen that, according to the present example, when the Forget-me-not-leaf extract and the water lily extract are included in a weight ratio of 1: 0.1 to 5, the skin moisturizing effect is remarkably improved. . In particular, as in Examples 3 and 4, it can be seen that when the forget-me-not-leaf extract and the water lily extract are included in a weight ratio of 1:1 to 3, the skin moisturizing effect is remarkably excellent.

Experimental Example 2: Evaluation of skin barrier improvement effect

Through a transepidermal water loss (TEWL) experiment, the skin barrier improvement effect was confirmed.

Specifically, the study was conducted on 25 healthy women indoors at 25°C, 45% relative humidity, and no air flow.

Skin barrier damage was induced by using a 1% aqueous solution of sodium lauryl sulfate (SLS), which is known to deteriorate the skin barrier due to its strong toxicity as a surfactant, in Examples 1 to 5 and Comparative Examples 1 to 4 After the cosmetic composition was applied to the upper arm of the arm, the amount of transdermal water loss (TEWL) was measured using TEWAMETER TM210 (C+K eletronic GmhH. Germany).

That is, the skin barrier recovery rate was confirmed by measuring the amount of change in the TEWL value according to time change (2, 4, 6, and 8 days), and the results are shown in Table 5 [unit: %] below.

Referring to Table 5, it can be seen that, according to this example, the transdermal moisture loss is suppressed, and the skin barrier recovery rate is excellent.

Specifically, looking at Examples 1 to 5 and Comparative Examples 1 to 2, it can be seen that, according to this example, when both the Forget-me-not and water lily extracts are included, the percutaneous moisture loss is further suppressed, and the skin barrier recovery rate is significantly improved. can

In addition, referring to Examples 1 to 5 and Comparative Examples 3 to 4, according to this example, when the Forget-me-not-leaf extract and the water lily extract are included in a weight ratio of 1: 0.1 to 5, the transdermal water loss is further suppressed, and the skin barrier It can be seen that the recovery rate is significantly improved. In particular, as in Examples 3 and 4, it can be seen that the skin barrier recovery rate is remarkably excellent when the forget-me-not-leaf extract and the water lily extract are included in a weight ratio of 1: 1 to 3.

Experimental Example 3: Skin stability evaluation

A human skin patch test was performed to determine whether the cosmetic compositions of Examples and Comparative Examples were irritating to the skin. The test was conducted on 20 women in their 20s and 30s who had never had a skin irritation hypersensitivity reaction in their past history and had no skin disease or skin allergy symptoms.

First, the test site was wiped with 70% ethanol and dried. The prepared test substance (cosmetic composition) was dropped into the Finn chamber (100X10, EPITEST) and then sealed and applied to the back of the test subject. The patch was applied for 24 hours, and after 1 hour and 24 hours after the patch was removed, the presence or absence of erythema and edema at the test site was observed using a magnifying glass (8MC-150, DAZOR).

The skin reaction was determined according to the regulations of the International Contact Dermatitis Research Group (ICDRG) (see Table 6), and the average skin reactivity was calculated by Equation 1 below.

Table 7 shows the results after about 24 hours and 48 hours after applying the patch, evaluated according to the above.

[Equation 1]

Referring to Table 7, it can be seen that, according to the present embodiment, the cosmetic composition including the Forget-me-not-leaf extract and the water lily extract as active ingredients is hypoallergenic and safe to the skin.

[Formulation Example]

Formulation Example 1: Preparation of softening lotion

Sodium hyaluronate was prepared as a 1% solution by dispersing it in purified water with a propeller mixer (3000 rpm). In Table 8 [unit: wt%], raw materials 2 to 8 except sodium hyaluronate were homogenized at 500 rpm in an aqueous dissolution tank using a propeller mixer, completely dissolved by heating at 75 ° C., and then cooled to room temperature. Thereafter, after completely dissolving the raw materials 9 to 11 in a separate dissolution tank, the mixture was put into the aqueous dissolution tank and stirred and mixed.

Here, a mixed extract (active ingredient) in which the forget-me-not-forget-me-not and water lily extracts were mixed in the same manner as in Example was added, and the mixture was sufficiently stirred and mixed to prepare a softening lotion.

On the other hand, in addition to the ingredients disclosed in the table for the preparation, it may further include known ingredients necessary for the preparation.

Formulation Example 2: Preparation of nutrient lotion

The carbomer was dispersed at 4000 rpm using a propeller mixer to prepare a 2% solution. In Table 9 [unit: wt%], the raw materials 2 to 6 were put into the aqueous dissolution tank, stirred and dispersed with a homomixer (2000 rpm), and then heated to 75 °C. Raw materials 7 to 14 were put into an oil phase dissolution tank and dissolved by heating to 75°C. Then, the dissolved oil phase was put into the aqueous dissolution tank to emulsify (3000 rpm/5 min), and then cooled to room temperature.

Here, a mixed extract mixed with forget-me-not-forget-me-not and water lily extract was added and thoroughly stirred and mixed to prepare a nutrient lotion.

On the other hand, it may further include known components necessary for the preparation in addition to the ingredients disclosed in the table for the preparation.

Formulation Example 3: Preparation of a pack

In a separate dissolution tank, the raw materials 2 to 8 of Table 10 [unit: wt %] are completely dissolved and mixed with stirring, and the mixed extract in which the forget-me-not-forget-me-not and water lily extracts are mixed, and other ingredients are added and stirred sufficiently. By mixing, a pack was prepared.

On the other hand, it may further include known components necessary for the preparation in addition to the ingredients disclosed in the table for the preparation.

Formulation Example 4: Preparation of cleansing foam

In Table 11 [unit: wt%], the aqueous phase and the oil phase were dispersed and dissolved, respectively, mixed and saponified, and then cooled to room temperature to prepare a cleansing foam.

On the other hand, it may further include known components necessary for the preparation in addition to the ingredients disclosed in the table for the preparation.

As described above, the description of the present invention is for illustration, and those of ordinary skill in the art to which the present invention pertains can easily transform into other specific forms without changing the technical spirit or essential features of the present invention. You will understand. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. For example, each component described as a single type may be implemented in a dispersed form, and likewise components described as distributed may be implemented in a combined form.

The scope of the present invention is indicated by the following claims rather than the above detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalent concepts should be interpreted as being included in the scope of the present invention. do.

Claims (5)

Forget-me-not ( Myosotis sylvatica ) extract and water lily ( Nymphaea tetragona Georgi ) extract as active ingredients,
The cosmetic composition for moisturizing the skin, characterized in that it contains the forget-me-not extract and water lily extract in a weight ratio of 1: 0.1 to 5.
delete The method of claim 1,
The cosmetic composition is
Based on the total weight of the cosmetic composition, the cosmetic composition for moisturizing the skin, characterized in that it comprises 0.0001 to 10% by weight of the forget-me-not extract and water lily extract.
The method of claim 1,
The forget-me-not extract and water lily extract,
As an extraction solvent containing at least one selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, dichloromethane, ethyl ether, hexane and 1,3-butylene glycol A cosmetic composition for skin moisturizing, characterized in that extracted.
The method of claim 1,
The cosmetic composition is
Any one formulation selected from the group consisting of softening lotion, nourishing lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water A cosmetic composition for moisturizing the skin, characterized in that it is.