KR100771438B1 - A cosmetic composition for acne improvement having sebum secretion and anti-inflammation effects - Google Patents

Abstract

A cosmetic composition is provided to excellently prevent and treat acne by comprising pantothenic acid having sebum secretion inhibition function and at least one extract selected from Phaseolus radiatus extract, Betula platyphylla var. japonica extract, and Rumex Crispus L. extract having anti-inflammatory effect. A cosmetic composition for improving acne comprises 0.01-10.0 wt.% of pantothenic acid and 0.001-20 wt.% of at least one extract selected from the group consisting of an extract of Phaseolus radiatus, an extract of Betula platyphylla var. japonica and an extract of Rumex Crispus L., wherein the extract is obtained by using water, C1-4 lower alcohol, a mixture solvent thereof, acetone, ethyl acetate, chloroform or 1,3-butyleneglycol as a solvent.

Description

A cosmetic composition for acne improvement having sebum secretion and anti-inflammation effects}

The present invention relates to a cosmetic composition for improving acne having a sebum secretion inhibitory and anti-inflammatory effect, and more particularly, composed of pantothenic acid having a sebum secretion inhibitory function and a mung bean extract having an anti-inflammatory effect, a birch extract, and an extract It relates to a cosmetic composition that can maximize the skin acne prevention and treatment effect by the synergistic action of at least one extract selected from the group consisting of.

Acne (acne vulgaris) is a skin disease caused by narrowing or clogging pores and the release of sebum. The hair follicles that make up the hair have sebaceous glands that secrete oil into the hair. Increased secretion of these sebaceous glands or clogged hair follicles, acne bacteria proliferate, causing acne. There are many causes of acne, but the most important is the proliferation and sebum secretion of the androgen (androgen), the acne-causing bacterium, or propionibacterium acnes. In acne patients, androgens stimulate sebaceous glands to increase sebum secretion, and the increased sebum becomes entangled and clumped with dead skin cells, blocking the entrance of the hair follicles. The clogged follicle openings provide an environment for the growth of anaerobic bacteria, propionibacterium acne, and the secreted lipases break down sebum, causing the hair follicles to irritate and eventually become inflamed. This acne is most visible on the skin, especially on the face, chest, back and neck.

Acne can be divided into non-inflammatory and inflammatory acne depending on the symptoms. Non-inflammatory is caused by the skin being stretched by a sebum mass that has been blocked by the typical lesions of acne, which develops into open and closed whiteheads. The open type means that the accumulation in hair follicles is exposed to the surface of the skin and is black. The closed type means that the sebum mass is not exposed to the skin surface and looks like skin color or white bumps. There are three basic types of inflammatory acne: papules, pustules, and tubers. Papules are millet-sized rashes produced by inflammation, and pustules are slightly raised rashes that appear yellow or grayish white due to pus inside. The nodule forms the pus by the contents of the scrim come out and induce an immune response to the surrounding skin tissue.

Acne prevention and treatment can be achieved through excessive sebum secretion and inflammation relief. Therefore, if you remove the cause in combination, acne can be suppressed very effectively. In particular, acne has recently been increased in adolescents as well as adults due to external stress, air pollutants, hormonal imbalances, etc. This phenomenon is becoming more noticeable each year, so many methods related to acne have been proposed. As a method for improving skin problems associated with acne, salicylic acid and triclosan and trihydroxy palmitic acid are applied to cosmetic compositions to open pores and promote sebum secretion to prevent and treat acne. (Korean Patent Laid-Open Publication No. 2004-0089072) discloses a method of suppressing sebum secretion by reducing the amount of sebum secretion in sebaceous glands by taking oligosaccharides (Japanese Patent Laid-Open No. 05-294836). In addition, a method of preventing acne by applying a violet extract having antimicrobial activity to propionibacterium acne to cosmetics has been proposed (Korean Patent Publication No. 2002-0082616).

The main object of the present invention is to prevent and treat skin acne by synergistic action of at least one extract selected from the group consisting of pantothenic acid having a sebum secretion inhibitory function, and mung bean extract, birch extract, and thorax extract having an anti-inflammatory effect. It is to provide a cosmetic composition that can maximize the effect.

The present invention relates to a cosmetic composition for acne skin, the active ingredient contains pantothenic acid in an amount of 0.01 to 10.0% by weight based on the total weight, mung bean extract, birch extract and sprout At least one extract selected from the group consisting of extracts is contained in an amount of 0.001 to 20% by weight, preferably 0.5 to 10% by weight, based on the total weight of the composition. This may cause skin irritation at high concentrations of more than 20% by weight, and the effect is insufficient at low concentrations of less than 0.001% by weight.

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Pantothenic acid or pantothenate used as an active ingredient in the present invention is a member of the vitamin B complex and known as vitamin B ₅ , and is a nutrient necessary for mammals including livestock and humans. Pantothenic acid is known to improve skin moisturizing function and stimulate skin regeneration. Dry skin is soft and elastic. Pantothenic acid is not only effective for preventing inflammation and itching, but it is also used for hair growth because it not only strengthens and softens the hair, but also restores and lusters damaged hair.

Mung bean (綠 豆) used as another active ingredient of the present invention is a perennial herb belonging to the dicotyledon rose rosaceae, its origin is assumed to be India, and is mainly distributed in Asia such as Korea, China, and India. Mung beans grow well on warm climate loam (a black soil mixed with sand and clay) and are about 30-80 cm in height. The stem has a thin, vertical vein, about 10 nodes, and branches. The leaves come out with a pair of cotyledons and freshly formed leaves, followed by three leaflets. Flowers are yellow and bloom in August, gathering several on axilla, but only 3-4 pairs bear fruit. Fruits are edible, initially green, but ripened and covered with long, coarse fur. It is 5-6cm long and contains 10-15 seeds in one pod. Seeds are often green, but yellow, greenish brown, and blackish brown. The varieties are divided into yellow, greenish brown, and blackish brown mung beans, depending on the color of the seeds, but green mung beans make up 90% of the total. The ingredients are 53-54% starch and 25-26% protein.

Mung beans (Phaseolus aureus, Phaseolus radiatus, Mung Bean, Green Bean) have strong antipyretic and detoxifying effects, and are widely used as antipyretic and antidote in oriental medicine. It is used for jade yongsushi acid, which makes your face look like jade, yeooksan, which is effective for removing skin impurities and dry skin, and yeogiyeooksan, which removes blemishes, and Oknaeyoung, which removes sweat bands that occur in summer. In addition, mung beans have been used effectively in yellow spear (bushrum), carbuncle (boil) and mumps (pandemic mumps) caused by dermal filamentous fungi in the stratum corneum. According to the inventors, the mung bean extract has an excellent effect of increasing the resistance to the stimulating agent of skin cells through antioxidant activity, free radical scavenging action, skin cell activity and regeneration, and shows histamine release effect. Indicates.

The birch tree (Betula Platyphylla Japonica), which is used as another active ingredient of the present invention, is a tree belonging to the birch family, which grows in the mountainous region of the northern part, reaching 20m in height. Bark is white, peeled horizontally, and young branches are reddish brown with spots. Leaves are triangular ovate, 5-7cm long, pointed at the end, sawtooth at the edge, petioles about 2cm long. Flowers bloom in April and May, and female flowers bloom at the same time and in the same tree with long doe inflorescences, which bloom before leaves. The fruit ripens in September, with wide wings from side to side. Cylindrical sack with fruit hangs down 4cm long. The juice of the tree is used for nourishing tonic and skin diseases, but very weak for urban pollution. Birch bark has been used as an important medicine as a medicine, it acts on the liver, lowers heat, removes moisture, stops coughing and cuts off the walls. In addition, the detoxification effect is very strong to remove inflammation, and diuretic effect can be used to relieve nephritis or edema. It has been used for the treatment of carbuncles and the like. In addition, it exhibits an inhibitory effect on the production of inflammatory mediators such as arachidonic acid, prostaglandin, leukotriene, and the like, and shows an excellent stimulating effect.

Rumex crispus (Rumex crispus) is another active ingredient of the present invention is called yangjegeun, solbang, muzzle, etc., is a perennial grass of the perennial herb that dries up in the summer and grows again when cool. Young leaves are eaten as herbs, and are said to be effective for ringworm, athlete's foot, and eczema. Since ancient times, it has been used in skin diseases such as amelioration, scabies and skin cancer. It is called Yangje-geun when the roots are cracked and rolled up in the autumn and dried in the sun. Soruja extract is very effective in suppressing the secretion and action of elastase and hyaluronidase, and is known to exhibit excellent anti-inflammatory effect through the inhibition of inflammation mediated cytokines such as IL-8 (Interleukin-8). have.
In particular, the present invention contains at least one member selected from the group consisting of mung bean extract, thorax extract and birch extract as an anti-inflammatory effect component, such an active ingredient has a stimulating alleviating effect to suppress the inflammatory mediators It is useful to provide a cosmetic composition for improving acne by improving the acne of the skin by showing the back and so on.

The skin improvement cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing And the like, but are not limited thereto.

When the formulation of the present invention is a paste, cream or gel, the carrier components include animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide and the like. Can be used.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol , Fatty acid esters of 1,3-butyl glycol, oils, glycerol aliphatic esters, polyethylene glycols or sorbitan.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the dosage form of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester as a carrier component , Microcrystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing klings, as a carrier component, an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid Amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition of the present invention has an acne prevention and treatment effect. This is to improve acne by sebum secretion function of pantothenic acid and the anti-inflammatory effect of mung bean extract, birch extract, Sorugung extract. Accordingly, the present invention is construed to include anti-aging, wrinkle improvement, moisturizing and skin elasticity use.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited to these embodiments according to the gist of the present invention to those skilled in the art to which the present invention pertains. Will be self explanatory.

Preparation Example 1 Preparation of Mung Bean Extract

10 kg of 70% ethanol aqueous solution was added to 1 kg of mung beans, and the mixture was left to stand at room temperature for 4 days, followed by extraction. The filtrate was filtered under reduced pressure, and dried at 40 ° C. for 24 hours to obtain 22.5 g of a light green powder. 980 g of purified water: butylene glycol (1: 1 weight ratio mixture) was added to 20 g of this powder, which was then stirred at room temperature to completely dissolve to obtain 1 kg of mung bean extract.

Preparation Example 2 Preparation of Birch Extract

10 kg of 70% ethanol aqueous solution was added to 1 kg of bark of birch and left to stand at room temperature for 4 days to extract. The filtrate was filtered and concentrated under reduced pressure, and dried at 40 ° C. for 24 hours to obtain 85 g of brown powder. 980 g of purified water: butylene glycol (1: 1 weight ratio mixture) was added to 20 g of this powder, which was then stirred at room temperature to completely dissolve to obtain 1 kg of birch extract.

(Manufacture example 3) Preparation of rust extract

5 kg of 70% ethanol aqueous solution was added to 1 kg of the root of Soru-Jung, and the mixture was left to stand at room temperature for 4 days and extracted. The filtrate was filtered and concentrated under reduced pressure, and dried at 40 ° C. for 24 hours to obtain 105 g of a light green powder. 980 g of purified water: butylene glycol (1: 1 weight ratio mixture) was added to 20 g of this powder, which was then stirred at room temperature to completely dissolve to obtain 1 kg of a sorbite extract.

Experimental Example 1 Anti-inflammatory Effect Test

In order to measure the anti-inflammatory effects of Mung bean extract, birch extract, and Soru-Jung extract, the anti-inflammatory effect was measured in 20 people with no skin disease or skin allergy symptoms. The age distribution of the test subjects was 25-35 years old, and five locations for anti-inflammatory effects were labeled on the forearm of the arm, and then the erythema (a * value) of the skin was measured with a chromatometer (Minolta). An extraction mixture of mung bean extract, birch extract, and 5% of three extracts and 5% of each of the three extracts was applied four times at 30 μl intervals at four measurement positions at 30 μl intervals. . Thirty minutes after the last application, 10 μl of methyl nicotinate (0.04%), a stimulant, was soaked in a paper disk and placed for 30 seconds. The paper disc was removed and rinsed under running water. After 30 minutes, four areas of application and one group of untreated group were measured with a chromameter, and the degree of erythema before the experiment and the erythema after the experiment were measured, and the anti-inflammatory effect was calculated as shown in Equation 1. Is shown in Table 1.

(Equation 1)

Anti-inflammatory effect (%) = (pretreatment-posttreatment) / pretreatment * 100

Anti-inflammatory effect Untreated group 5% Mung Bean Extract 5% Birch Extract 5% Sorbuch Extract Extract mixture Inhibition of Inflammation (%) 0.3 21 24 35 76

As can be seen from Table 1, when comparing the anti-inflammatory effect, each extract showed an anti-inflammatory effect, but showed the best stimulating alleviation effect in the complex containing all three extracts.

Production Example 4 Example 1 and Comparative Examples 1, 2, and 3

To the cosmetic composition having a composition ratio of the following Table 2, pantothenic acid, the cosmetic composition of the Examples and Comparative Examples each containing 5% by weight of the extract mixture was prepared.

ingredient Example 1 (% by weight) Comparative Example 1 (% by weight) Comparative Example 2 (wt%) Comparative Example 3 (wt%) Pantothenic Acid 5.0 5.0 - - Extract mixture 5.0 - 5.0 - glycerin 5.1 5.1 5.1 5.1 Propylene glycol 4.2 4.2 4.2 4.2 Tocopheryl Acetate 3.0 3.0 3.0 3.0 Liquid paraffin 4.6 4.6 4.6 4.6 Triethanolamine 1.0 1.0 1.0 1.0 Squalane 3.1 3.1 3.1 3.1 Macadamia Nuts 2.5 2.5 2.5 2.5 Polysorbate 60 1.6 1.6 1.6 1.6 Sorbitan sesquirrolate 1.6 1.6 1.6 1.6 Propylparaben 0.6 0.6 0.6 0.6 Carboxyl Vinyl Polymer 1.5 1.5 1.5 1.5 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount system 100 100 100 100

(Experimental example 2) sebum secretion inhibitory effect measurement

The sebum secretion inhibitory effect was compared with respect to the cosmetics prepared by Table 2. Sebum secretion inhibitory effect is divided into four groups of 10 each for 40 women with oily skin of 15 to 25 years old each morning of each cosmetic prepared in Example 1 and Comparative Examples 1, 2, 3 of Preparation Example 4 After application to the face twice a day and in the evening, after 3, 6, 9 days sebum secretion was measured using a skin oil meter (Sebum meter SM 815, Courage + Khazaka electronic GmbH, Germany). The experiment was conducted at constant temperature and humidity conditions of 25 ° C. and 45% relative humidity. Using sebum secretion as the default value, after applying Example 1 and Comparative Examples 1, 2, 3, the sebum secretion effect is measured by measuring the change of sebum secretion amount, and the sebum secretion amount changed from the initial value is expressed as Equation 2 It was calculated and the results (average value of each group) are shown in Table 3.

(Equation 2)

Sebum excretion = ((S _{t = 0} -S _{t = i} )) / S _{t = 0} * 100

S _{t = 0} : Initial sebum secretion before application

S _{t = i} : sebum secretion by date after application

Sebum secretion inhibition rate (%) 3 days later 6 days later 9 days later Example 1 52 61 72 Comparative Example 1 45 54 63 Comparative Example 2 15 18 21 Comparative Example 3 9 11 14

As can be seen from the results of Table 3, Example 1 and Comparative Example 1, which contain 5% by weight of pantothenic acid, had better sebum secretion inhibitory effect than Comparative Examples 2 and 3, which do not contain pantothenic acid, and particularly, pantothenic acid and the extract mixture were In Example 1 included it can be seen that the sebum secretion function is the best.

Experimental Example 3 Anti-inflammatory Effect Experiments of Example 1 and Comparative Examples 1, 2, and 3

In order to examine the anti-inflammatory effect on Preparation Example 4, five ICR mice were divided into five groups. Using the right ear of the ICR mouse as a test site, clean the ear with ethanol before applying the sample, continuously apply 20 μl of the sample once a day for 4 days, and apply arachidonic acid to the right ear one hour after the last application. After 1 hour of application of 2 mg / ear, the degree of ear edema was repeatedly measured three times on both ears with a micrometer. The anti-inflammatory effect was determined based on the arachidonic acid treated group as shown in Equation 3 below, the edema inhibition rate is shown in Table 4 below. The value is shown by the average value of each group.

(Equation 3)

Inhibition Rate of Inflammation (%) = (A-B) / A * 100

A: change of control ear (thickness of the ear after sample treatment-thickness of ear before sample treatment)

B: Change of Ear in Sample Treatment Group (Thickness of Ear after Sample Treatment-Ear Thickness before Sample Treatment

division Ear thickness (㎛)  Inhibition of Inflammation (%) Before sample processing After sample processing Control 251 543 - Example 1 262 343 72.3 Comparative Example 1 246 452 29.5 Comparative Example 2 245 401 53.4 Comparative Example 3 254 520 9.0

As can be seen from the results of Table 4, Example 1 containing pantothenic acid and the mixed extract showed the highest anti-inflammatory effect.

Experimental Example 4 Evaluation of Treatment Effect in Acne Patients

Each of the 40 acne patients were divided into 4 groups of 10 people, each of which was prepared in Example 1 and Comparative Examples 1, 2, and 3 of the Preparation Example 4 to be applied twice a day in the morning and evening after washing the face. After a month, the degree of improvement of acne was evaluated. The results are shown in Table 5.

division Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Acne improvement 2 3 3 2 Acne Extinction 8 4 5 6 Acne recurrence 0 3 2 2

Formulation Example 1 Skin Lotion

The skin lotion containing the extract mixture obtained above and pantothenic acid was prepared according to a conventional method.

Raw material name Content (% by weight) Pantothenic Acid 5.0 Extract mixture 5.0 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone-9 2.0 Carboxyl Vinyl Polymer 1.0 glycerin 3.5 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

Formulation Example 2 Lotion

A lotion containing the extract mixture and pantothenic acid obtained above as described in Table 7 below was prepared according to a conventional method.

Raw material name Content (% by weight)  Pantothenic Acid 5.0 Extract mixture 5.0 Cetostearyl alcohol 1.0 Glyceryl Monostearate 0.8 Sorbitan monostearate 0.3 Porofilparaben 0.1 Polysorbate 60 1.0 Mineral oil 5.0 Pyromethicone 3.0 Dimethicone 0.5 Allantoin 0.1 glycerin 5.0 Alcohol 2 Propylene glycol 3.0 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

Formulation Example 3 Essence

Essences containing the extract mixture and pantothenic acid obtained as described above in Table 8 were prepared according to a conventional method.

Raw material name Content (% by weight) Pantothenic Acid 5.0 Extract mixture 5.0 1,3-butylene glycol 4.0 glycerin 3.0 Allantoin 0.5 Panthenol 0.1 EDTA-2Na 0.01 ethanol 5.0 Triethanolamine 1.5 Squalane 2.0 Beeswax 2.5 Polysorbate 60 3.5 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.5 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

Formulation Example 4 Pack

As shown in Table 9 below, a pack containing the extract mixture and pantothenic acid obtained above was prepared according to a conventional method.

Raw material name Content (% by weight) Pantothenic Acid 5.0 Extract mixture 5.0 Ethyl alcohol 3.0 EDTA-2Na 0.05 Propylene glycol 5.0 Glyceline 4.5 Cabopol 1.5 Polyoxide 0.2 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100

Formulation Example 5 Massage Cream

Massage creams containing the extract mixture and pantothenic acid obtained as described above in Table 10 were prepared according to a conventional method.

Raw material name Content (% by weight) Pantothenic Acid 5.0 Extract mixture 5.0 glycerin 4.0 Vaseline 3.5 Triethanolamine 0.5 Liquid paraffin 24.0 Squalane 3.0 Beeswax 2.1 Tocopheryl Acetate 0.1 Polysorbate 60 2.4 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.3 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

As described in detail above, the present invention contains at least one selected from the group consisting of pantothenic acid and mung bean extract, birch extract and Soru-lung extract, the composition has excellent synergistic effect on sebum secretion and anti-inflammatory action It provides a cosmetic composition for improving acne showing excellent effect in the prevention and treatment of acne.

Claims (6)

Acne improvement cosmetic composition comprising at least one extract selected from the group consisting of pantothenic acid and mung bean extract, birch extract and Soruch extract. delete According to claim 1, wherein the pantothenic acid is 0.01 to 10.0% by weight based on the total weight of the composition, the extract is acne improvement cosmetic composition characterized in that it contains 0.001 to 20% by weight based on the total weight of the composition. delete The method of claim 1, wherein each extract is water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, a mixed solvent of the lower alcohol and water, acetone, ethyl acetate, chloroform or 1,3-butylene glycol is added Cosmetic composition for improving acne, characterized in that the extraction. The composition of claim 1, wherein the composition has a formulation selected from the group consisting of softener, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray and powder. Cosmetic composition for improving acne characterized in that.