KR102236236B1 - Composition for improving scalp containing natural extracts - Google Patents

Abstract

The present invention relates to a composition for improving a scalp, containing an Angelica asiatica extract, a ginseng extract, a licorice extract, a pleuropterus multiflorus extract and a ginseng extract. The composition reduces dandruff, improves efficacy for scalp itchiness, and improves hair loss prevention effect by adding sapwood leaf extracts and fermented fern wood sap to the herbal medicine extracts.

Description

Composition for improving scalp containing natural extract {COMPOSITION FOR IMPROVING SCALP CONTAINING NATURAL EXTRACTS}

The present invention relates to a composition for improving the scalp including Angelicae extract, Koginseng extract, licorice extract, Hasu-O extract and ginseng extract, and by adding the herbal extracts of Korean herbal medicine leaves extract and fermented sap of Goryeossensis to reduce dandruff and scalp itching It improves the efficacy of, and further relates to a composition characterized in that it has an excellent hair loss prevention effect.

The scalp is composed of epidermis, dermis, and subcutaneous tissue, and the outermost tissue is the epidermis. The epidermis functions to protect the body's sensitive tissues from damage. However, due to changes in external temperature and humidity, various physical and chemical external stimuli such as pollutants, stress, and lack of influence, the function of the scalp may be lost, and furthermore, it may affect hair loss. In addition, in the modern society that values beauty, many people, regardless of age or sex, use hair-dye and perm agents to satisfy their desire to express their individuality. However, in the case of some sensitive scalp, irritation and inflammation such as itchiness or itching of the scalp are induced due to chemical procedures such as dyeing and perm, which leads to environmental hair loss.

In this way, it protects the scalp from stimulus from the environment, stress, and chemical procedures caused by various causes, and can promote hair growth while preventing hair loss, and studies on components that are eco-friendly and harmless to the environment and humans continue. Has become. There have also been many attempts to improve the condition of the scalp and hair by applying or taking it on the scalp using extracts of herbal ingredients.In the case of using milky skin extract (Korean Patent No. 15377773), rose flower extract, screen extract, green tea extract, mugwort When using extracts (Korean Patent No. 1509608), etc., have been disclosed, but in order to prevent hair loss and maximize the hair wool effect, only one natural product or herbal medicine did not have a great effect, and only has the function of preventing hair loss and wool. As a result, there are disadvantages such as lack of scalp improvement functions such as improving dandruff and relieving itchiness.

As described above, the cosmetic compositions described above cause economic burden and pain to people, or cause side effects, and have problems such as using only a temporary or fragmentary pharmacological mechanism, so that the effect is more excellent and lasting, There is an increasing demand for compositions without side effects.

Korean Patent Application Publication No. 10-2017-0100828

An object of the present invention is any one or more herbal medicinal extracts selected from the group consisting of angelica extract, gosam extract, licorice extract, hawthorn extract and ginseng extract; Serrata leaf extract; And it is intended to provide a composition for improving the scalp containing;

An aspect of the present invention is any one or more herbal medicinal extracts selected from the group consisting of angelica extract, gosam extract, licorice extract, hawthorn extract and ginseng extract; Serrata leaf extract; And it relates to a composition for improving the scalp containing;

The five kinds of herbal medicinal extracts including Angelicae, Gosam, Licorice, Hasuoh and Ginseng are made in combination with Western medicine that is good for hair loss and wool, so that hair is rich and strong through smooth supply of nutrients to the scalp. It is known to have an effect of suppressing it.

In the present invention, it was confirmed that the effect of suppressing dandruff production and improving scalp itching was remarkably improved by adding the extracts of the five kinds of oriental medicinal herbs and/or fermented sap of Goro serrata, and protects the scalp and makes the hair healthy. A composition for improving the scalp was developed.

The "extract" of the present invention is an extract obtained by extraction treatment of five kinds of Angelicae, Gosam, Licorice, Sewage, Ginseng and/or Sakura leaves, a dilution or concentrate of the extracts, a dried product obtained by drying the extract, the It includes extracts of all formulations that can be formed using the extract itself and the extract, such as preparations or purified products of extracts, or mixtures thereof.

The extract of the present invention may be extracted from natural, hybrid or variety plants of the leaves of Angelicae, Gosam, Licorice, Hasuoh, Ginseng and/or Sakura, and may be extracted from plant tissue cultures.

The method of extracting the extract of the present invention is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, and these may be performed alone or in combination of two or more methods.

The type of the extraction solvent used in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ether, ethyl acetate, butyl acetate, trichloromethane, dichloromethane, chloroform, hexane and 1, 3-butylene glycol It is one or more selected from the group consisting of, and may be used alone, in combination of two or more.

In the present invention, " Styrax japonicus " is a tree with a good scent as it has the meaning of'comfortable scent' of the generic name Styrax. There are 150 species of 11 genera distributed worldwide, and 8 species are registered in Korea's national standard plant list. In Korea, the Korean Tepaku is a deciduous tree that is distributed in the lowlands of the south of the central region and grows about 4 to 10 m. It has the characteristics of being distributed in mountain valleys and waterfronts. The leaves of the Tepiki tree are alternate and have an oval shape, and the young leaf of the Tepiki tree is used as a composition for external use for the skin, as it has various antioxidant and inflammation improvement effects.

Specifically, the leaf extract is fermented by inoculating a strain in the leaf extract of the leaf bamboo tree, and more specifically, the leaf extract may be an extract fermented by inoculating a strain of the genus Lactobacillus.

In the present invention, the "Sap of the Goro-so" refers to a liquid flowing in about 10 kinds of maple trees that grow wild in high altitudes of 500 to 1000 m above sea level. The sap of the Gorosevils tree is known to have various effects such as postpartum diseases, neuralgia, gastrointestinal diseases, and high blood pressure due to its high content of various minerals such as magnesium, calcium and vitamins.

Specifically, the fermented sap of Goro-so-namu is fermented by inoculating a strain, and more specifically, may be fermented by inoculating yeast.

The yeast is Saccharomyces cerevisiae , Saccharomyces byanus , Saccharomyces uvarum , Saccharomyces pastorianus , and Saccharomyces pastorianus. It may be any one selected from the group consisting of Saccharomyces paradoxus , and more specifically, Saccharomyces cerevisiae .

In addition, the composition may further include rosemary and menthol. Specifically, the rosemary oil may maintain the glossiness of the hair, and the menthol may impart a refreshing feeling and a refreshing feeling of the scalp.

The composition may further include rosemary leaf extract, peppermint leaf extract, lavender flower extract, black bean extract, cane root extract of a thief, cinnamon root extract, and green tea extract, and has scalp soothing, sebum control, and scalp strengthening effect. Extracts can be added without limitation.

The composition is characterized by having an effect of inhibiting dandruff production, alleviating scalp itching and preventing hair loss.

In one embodiment of the present invention, as a result of applying a scalp pack prepared using a composition comprising a herbal medicinal herb extract, a leaf extract and a fermented fermented sap, it was confirmed that dandruff production was remarkably reduced (Table 4).

In one embodiment of the present invention, it was confirmed that the scalp itching was significantly reduced in the case of the scalp pack containing the fermented sap from the fermented fern tree compared to the scalp pack that did not contain the fermented sap of the blastomere tree (Table 5).

In addition, in an embodiment of the present invention, as a result of applying a scalp pack containing the composition of the embodiment of the present invention to a person having hair loss symptoms, the effect of preventing hair loss and woolen hair was confirmed. It was confirmed that the prevention and wool function effect was remarkably improved (Table 6).

When the composition is a cosmetic composition or a quasi-drug composition, it may be prepared in any formulation conventionally prepared in the art. For example, in the case of a quasi-drug composition. Scalp tonic, scalp lotion, scalp cream, scalp serum, scalp essence, scalp ampoule, scalp treatment, scalp conditioner, scalp shampoo, scalp pack, hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair Conditioner, hair shampoo, hair rinse, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, eyelash nutrient, pet shampoo, pet rinse, hand sanitizer, detergent soap, soap, disinfectant cleaner, wet tissue, mask, ointment, It may be a patch or filter filler or the like.

In addition, if the composition is a cosmetic composition, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray, etc. It may be formulated as, but is not limited thereto.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as a carrier component. I can.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, and crystallites Sex cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

When the formulation of the present invention is a surfactant containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters may be used.

Various conventional ingredients formulated in a conventional scalp improvement composition according to various formulations or suitable for an end purpose are well known to experts in the art.

The composition according to an embodiment of the present invention may be a composition for improving scalp containing 0.01 to 10% by weight of an active ingredient, and 0.01 to 8 in order to obtain remarkable scalp and hair strengthening effect by application of 1 to 3 times a day. It may contain an active ingredient of 0.01 to 6% by weight, more preferably 0.01 to 6% by weight.

The composition according to the present invention is not harmful to the human body even if it is used daily by adding fermented product of Sakura tree leaf extract and Goro serrata sap to five kinds of herbal medicinal extracts including Angelicae, Gosam, Licorice, Hasuoh and Ginseng, and has side effects. It protects the scalp and has excellent anti-hair loss effect.

The effects of the present invention are not limited to the above effects, and should be understood to include all effects that can be deduced from the configuration of the invention described in the detailed description or claims of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings, but it is obvious that the present invention is not limited by the following examples.

Preparation Example 1. Preparation of Oriental Herb (Angelica, Gosam, Licorice, Hasuoh and Ginseng) Extract

After washing angelica, gosam, licorice, sorghum and ginseng with water, it was completely dried at room temperature and pulverized to obtain 100 g of each pulverized product. The pulverized products of angelica, gosam, licorice, hasuoh and ginseng were immersed and extracted for 12 hours at a temperature of 50°C using 10 times the volume of ethanol aqueous solution (50% mass concentration) for each 100 g. Each extract was filtered through a filter, and the extract obtained by repeatedly extracting three times in the same manner for the remaining raw materials was mixed to complete a composite extract. The complex extract was concentrated under reduced pressure at 30° C. and then freeze-dried to obtain a solid.

Preparation Example 2. Preparation of a leaf extract of serrata japonica

2-1. Shrub Leaf Extract

Styrax japonicus was washed with water, dried at room temperature, and pulverized to obtain 100 g of a pulverized product. Each pulverized product was subjected to immersion extraction for 7 days at room temperature using 70% ethanol in a volume of 20 to 100 g as a solvent. The extract was filtered through a 250 mesh filter and a 3 μm filter, concentrated under reduced pressure at 40° C., and then freeze-dried to obtain a solid content of the extract.

2-2. Fermented Extract of Sakura Leaf

To prepare the leaf extract of the bamboo leaves of Preparation Example 2-1. Inoculum for the fermentation of lactic acid bacteria culture medium (Lactobacillus MRS Broth, deep nose, the United States of America) The Lactobacillus ramno suspension (Lactobacillus rhamnosus) KCTC was used as 5033, after the culture is completed ttaejuk to 1 x 10 ⁹ cfu / ml concentration wood cultured in Leaf extract was inoculated. Fermentation was carried out while maintaining at 25 to 35 ℃ for 1 to 3 days using a fermentation tank. The fermented product after fermentation was completed was separated from the raw material to remove the cells, and finally filtered using 0.2 μm filter paper. The fermented extract from the extract and filtrate of the leaves of the oak tree was lyophilized and used.

Preparation Example 3. Fermented sap of blastula wood

After inflicting some wounds on the goryeosae trees that grow naturally in the Samsan Yugok, a clean container was attached to collect the naturally flowing sap to obtain pure Goro’s tree sap. Afterwards, yeast ( Saccharomyces cerevisiae ) bacteria were added to the collected sap of the Bronchia tree so as to be 2 to 5 parts by weight based on 100 parts by weight of the sap and fermented at 40°C for 48 hours. Then, 30% of butylene glycol was added to the fermented raw material, extracted for 7 days at room temperature, filtered through a 400 mesh filter cloth, and filtered through a 0.45 μm filter to prepare a fermentation broth.

Examples and Comparative Examples

In this Example, Examples and Comparative Examples including the compositions of Preparation Examples 1 to 3 are shown in Table 1 below.

ingredient
[Content (parts by weight)] Example 1 Example 2 Comparative Example 1 Comparative Example 2 Shrub Leaf Extract 7 - - Fermented Extract of Sakura Leaf - 7 - Fermentation sap 6 6 - 7 Angelica extract 3 3 6 5 Sophora extract 3 3 6 5 Licorice extract 3 3 6 5 Sewage extract 3 3 5 3 Ginseng extract 3 3 5 3 Rosemary oil 1.5 1.5 1.5 1.5 menthol 0.5 0.5 0.5 0.5

Experimental Example 1. Scalp safety evaluation

20 adult females were selected and the composition of Example 3 in Table 2 was used twice a week for 4 consecutive weeks, and then an interview by a dermatologist and an examination of the scalp were conducted in parallel with the skin adverse reactions (emotional reactions and other Estimated response) was confirmed and observed, and the suitability of the sample was judged.

No. Ingredient name content(%) One 1,3-butylene glycol Balance 2 Myristyl alcohol 5 3 Behentrimonium chloride 5 4 Steatrimonium chloride (80%) 5 5 Cetrimonium chloride (30%) 3 6 L-menthol 0.1 7 Salicylic Acid 0.2 8 Cyclopentasiloxane 3 9 Betaine 0.3 10 Caprylyl Glycol 0.1 11 4-hydroxyacetophenone 0.3 12 Dipropylene glycol 2.0 13 Ethanol (80%) 20 14 Hydrolyzed Collagen 0.1 15 Dex-panthenol 0.5 16 Tromethamine Appropriate amount 17 Dipotassium glycyrrhizate 0.03 18 Spices 0.3 19 Examples 1,2 or Comparative Examples 1 and 2 5

Specifically, a dermatologist visually inspected the test site and finally evaluated the safety of the sample by examining the time of occurrence, frequency, intensity, duration, etc. of the stimulus reported by the subject. One of the 20 subjects who normally ended the experiment reported weak itching and weak papules on the scalp after using the sample, and one subject reported tingling in the eyes immediately after using the sample. Since the symptoms were not severe and did not recur even with continuous sample use, the association with the sample was determined as “Related”. As a result of safety observation by a dermatologist, the reported reaction was judged not to be an irritation at a level that affects the safety of the scalp. Therefore, the scalp safety grade of this sample was judged as “good”. Table 3 shows the results of the overall efficacy of the sample.

Subject Scalp Safety (Acceptability) Very good good Slightly good usually Bad Example 1 n 2 9 6 3 0 % 55 30 15 0 Example 2 n 3 9 5 3 0 % 60 25 15 0

As shown in Table 3, the safety of the scalp of Examples 1 and 2 was very excellent, and it was confirmed that it can be used for the purpose of protecting and strengthening the scalp.

Experimental Example 2. Measurement of reduction rate of dandruff

Thirty men and women with a relatively large amount of dandruff were selected to use the scalp pack of Table 2 including the compositions of Examples and Comparative Examples for 1 month, respectively.

Before the start of the test, wash with a conventional shampoo and collect the accumulated dandruff for 3 days.The weight of the collected dandruff and the scalp packs of Examples and Comparative Examples were washed once a day after shampooing, and the accumulated dandruff for 3 days after the end of the test. The weight was compared and evaluated. At this time, to collect the accumulated dandruff, have an experienced tester wash the scalp of the test subjects using about 5 g of a sample, and then wash it with about 2 to 3 liters of water, and then wash the washed water with a filter with an 800 micro pore size. The dry weight of the dandruff on the filter was measured, and the dandruff reduction rate was calculated by the following equation.

[Equation 1]

Dandruff reduction rate (%) =

division Dandruff reduction rate (%) Example 1 33.8 Example 2 39.1 Comparative Example 1 23.9 Comparative Example 2 24.5

As shown in Table 4, the scalp packs of Examples 1 and 2 showed a significantly higher rate of dandruff reduction than the case of using the scalp packs of Comparative Examples. It was confirmed that it exerts an excellent synergistic effect in reducing dandruff by mixing with it.

Experimental Example 3. Scalp itching reduction effect confirmation

30 men and women who have a lot of dandruff or feel itchy scalp were randomly selected to use the scalp pack containing the compositions of Examples and Comparative Examples once a day for 8 weeks after using the shampoo, and then the effect of reducing scalp itching Was observed.

The itching reduction effect was measured based on a 5-point scale method. 1. No effect 2. Some effect 3. Normal effect 4. Good effect 5. Very good effect

division Itching reduction effect Example 1. 4.2 Example 2 4.3 Comparative Example 1 2.5 Comparative Example 2 3.8

As shown in Table 5, it was confirmed that the scalp itching was significantly improved when the scalp pack containing the composition of the example was applied, and in particular, it was confirmed that the fermented sap of Goro-so-namu was excellent in improving effect on scalp itching.

Experimental Example 4. Hair loss prevention ability and wool ability check

For adult males with hair loss symptoms, the herbal medicinal extracts of Examples 1 and 2, leaf extracts and fermented sap of birch trees were used to evaluate the effect of preventing hair loss and the effect of wool. At this time, 30 adult males aged 40-50 years old with an average daily number of hair loss of 100 or more were selected as subjects, and the scalp pack shown in Table 2 was used, and the method of use was about 2-3 times a day on the hair loss area for 6 months. About 3 ml was evenly applied with a finger, then rubbed to be sufficiently absorbed, and washed off after 5 to 10 minutes. And after 6 months, wool and hair loss were measured based on the 5-point scale method as follows. 1. No effect 2. Some effect 3. Normal effect 4. Good effect 5. Very good effect

division Prevention of hair loss and effect of woolen ability Example 1. 3.9 Example 2 4.3 Comparative Example 1 3.6 Comparative Example 2 3.6

As shown in Table 6, it can be seen that the wool and hair loss prevention ability of the example composition is superior to that of the comparative example, and in particular, wool and hair loss prevention of the scalp pack in which an extract fermented with lactic acid bacteria is added to the herbal medicine extract. The results as described above show synergistic effects in improving the scalp, as well as preventing hair loss and promoting hair growth by adding the extract of Korean herbal medicine with excellent scalp protection effect. It shows that it can be used in various ways for improving the scalp.

The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative and non-limiting in all respects. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as being distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the claims to be described later, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be construed as being included in the scope of the present invention.

Claims (7)

Herbal medicinal extract including 3 parts by weight of Angelicae extract, 3 parts by weight of Gosam extract, 3 parts by weight of licorice extract, 3 parts by weight of Hasuoh extract, and 3 parts by weight of ginseng extract, based on the weight of the total composition; 7 parts by weight of the fermented extract of the leaves of the bamboo leaves; 6 parts by weight of fermented sap of gorosaurus tree; 1.5 parts by weight of rosemary oil; And as a composition for improving the scalp containing 0.5 parts by weight of menthol,
The herbal medicinal extract was obtained by immersion extraction of dried crushed product of Angelicae, Gosam, Licorice, Hasuoh and Ginseng using 50% ethanol as a solvent for 12 hours at 50°C, filtration, concentration under reduced pressure at 30°C, and freeze-drying. ,
The fermentation extract of S. bamboo leaves was extracted by immersion for 7 days at room temperature using 70% ethanol as a solvent, filtered, concentrated under reduced pressure at 40° C., and freeze-dried to obtain lactobacillus . It is an extract fermented by inoculating the genus strain,
The fermentation sap is fermented at 40°C for 48 hours by adding yeast (Saccharomyces cerevisiae ) bacteria to 2 to 5 parts by weight based on 100 parts by weight of the sap, and then fermented at room temperature by adding 30% of butylene glycol to the fermented raw material. Extracted for 7 days and then obtained by filtration,
The composition is characterized in that it has the effect of inhibiting dandruff production, alleviating scalp itching and preventing hair loss, a composition for improving scalp. delete delete delete delete delete The method of claim 1,
The composition includes scalp tonic, scalp lotion, scalp cream, scalp serum, scalp essence, scalp ampoule, scalp treatment, scalp conditioner, scalp shampoo, scalp pack, hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair Gel, hair conditioner, hair shampoo, hair rinse, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, eyelash nutrient, pet shampoo, pet rinse, ointment or patch form, the scalp improvement composition.