JPH0624943A - Hair-growing agent - Google Patents
Hair-growing agentInfo
- Publication number
- JPH0624943A JPH0624943A JP20608992A JP20608992A JPH0624943A JP H0624943 A JPH0624943 A JP H0624943A JP 20608992 A JP20608992 A JP 20608992A JP 20608992 A JP20608992 A JP 20608992A JP H0624943 A JPH0624943 A JP H0624943A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- present
- growing agent
- growth
- theophylline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明はテオフィリンを有効成分
として含有する育毛剤に関する。本発明における育毛剤
とは脱毛を防止し、発毛、育毛を促進し得る目的で利用
される。FIELD OF THE INVENTION The present invention relates to a hair restorer containing theophylline as an active ingredient. The hair restorer in the present invention is used for the purpose of preventing hair loss and promoting hair growth and hair growth.
【０００２】[0002]
【従来の技術】従来、男性型脱毛症および円形脱毛症な
どの治療・改善を目的として、血行促進剤、細胞賦活
剤、ビタミン剤、抗男性ホルモン剤を有効成分とする育
毛剤が知られている。しかしながら、脱毛および発毛の
メカニズムについては未だ不明な点が多く、十分な治療
・改善効果は得られていない。2. Description of the Related Art Heretofore, hair growth agents containing blood circulation promoters, cell activating agents, vitamins, and anti-androgen agents as active ingredients have been known for the purpose of treating and improving male pattern baldness and alopecia areata. There is. However, there are still many unclear points about the mechanism of hair loss and hair growth, and sufficient therapeutic and improving effects have not been obtained.
【０００３】[0003]
【発明が解決しようとする課題】したがって、脱毛を防
止し、発毛、育毛を促進する有効成分の開発と、その育
毛剤への応用が望まれている。Therefore, it is desired to develop an active ingredient for preventing hair loss, promoting hair growth and hair growth, and applying it to a hair growth agent.
【０００４】[0004]
【課題を解決するための手段】斯かる実情に鑑み、本発
明者は多くの天然物および化合物について育毛効果を検
討した結果、下記一般式（１）で表されるテオフィリン
に強い育毛効果を有することを見いだし、本発明を完成
するに至った。In view of such circumstances, the present inventor has examined the hair-growth effect of many natural products and compounds, and as a result, has a strong hair-growth effect on theophylline represented by the following general formula (1). As a result, they have completed the present invention.
【化１】なお、本発明で用いられるテオフィリンは1、3-
ジメチルキサンチンであり、天然または合成されたもの
の何れでもよく、市販品を利用することができる。Embedded image Theophylline used in the present invention is 1,3-
It is dimethylxanthine, which may be natural or synthetic, and commercially available products can be used.
【０００５】本発明に用いられるテオフィリンは、全組
成中の配合量は0.001〜10重量%（以下単に%で示す）で
あればよく、より好ましくは 0.01〜5%である。0.001%
未満では本発明の目的とする効果が十分ではなく、一方
上限を越えても、その増加分に見合った効果の向上は望
めないものである。また、本発明の育毛剤はテオフィリ
ンの他に必要に応じて、添加剤および育毛剤として慣用
されている他の薬剤を本発明の効果を損なわない範囲で
適宜配合することができる。添加剤としては、例えば、
ヒノキチオール、塩化ベンザルコニウム、ヘキサクロロ
フェン、ウンデシレン酸などの抗菌剤、メントールなど
の清涼剤、高級脂肪酸、高級アルコール類、界面活性
剤、香料、酸化防止剤、エタノール、精製水、保湿剤な
どが挙げられる。また、育毛剤として慣用されている他
の薬剤としては、例えば、センブリエキス、アセチルコ
リン誘導体などの血管拡張剤、スウェルチノーゲン、ビ
タミンＥニコチン酸エステル、トウガラシチンキ、朝鮮
ニンジンを挙げることができ、これらを1種または2種以
上混合して使用することができる。The theophylline used in the present invention may be contained in the composition in an amount of 0.001 to 10% by weight (hereinafter simply referred to as%), and more preferably 0.01 to 5%. 0.001%
If it is less than the above range, the desired effect of the present invention is not sufficient. On the other hand, even if it exceeds the upper limit, improvement in the effect commensurate with the increase cannot be expected. In addition to theophylline, the hair-growing agent of the present invention may optionally contain additives and other agents commonly used as a hair-growing agent as long as the effects of the present invention are not impaired. As the additive, for example,
Antibacterial agents such as hinokitiol, benzalkonium chloride, hexachlorophene, and undecylenic acid, cooling agents such as menthol, higher fatty acids, higher alcohols, surfactants, fragrances, antioxidants, ethanol, purified water, moisturizers, etc. To be In addition, examples of other agents commonly used as a hair-growing agent include cembly extract, vasodilators such as acetylcholine derivatives, swelltinogen, vitamin E nicotinic acid ester, capsicum tincture, and carrot ginseng. Can be used alone or in combination of two or more.
【０００６】本発明の育毛剤は、外用剤として用いられ
るものであればその剤型については制限されるものでは
なく、例えば、ヘアトニック、ヘアローション、ヘアク
リーム、エアゾール、シャンプー、リンスなどが挙げら
れる。The hair-growing agent of the present invention is not limited in its dosage form as long as it can be used as an external preparation, and examples thereof include hair tonics, hair lotions, hair creams, aerosols, shampoos and conditioners. To be
【０００７】[0007]
【実施例】つぎに、代表的な実施例によって本発明にお
ける育毛剤の製剤化方法を具体的に挙げるが、本発明は
これに限定されるものではない。 実施例−１ ヘアローション ［製法］成分1〜7および成分8〜10をそれぞれ 70〜75゜C
に加温溶解した後、成分1〜7に成分8〜10を加えて乳化
し、30゜Cまで冷却してヘアローションとする。EXAMPLES Next, the method for formulating the hair-growth agent of the present invention will be specifically described with reference to typical examples, but the present invention is not limited thereto. Example-1 Hair lotion [Manufacturing method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.
【０００８】実施例−２ ヘアトニック 1.95%エタノール 60.0部 2.テオフィリン 2.0 3.グリセリン 2.0 4.精製水 36.0 ［製法］テオフィリンをエタノールに懸濁し、グリセリ
ン、精製水を加え、十分攪拌混合し、ヘアトニックとす
る。Example-2 Hair Tonic 1.95% ethanol 60.0 parts 2. Theophylline 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production Method] Theophylline is suspended in ethanol, glycerin and purified water are added, and the mixture is sufficiently stirred and mixed to give hair. Tonic.
【０００９】実施例−３ シャンプー 1.アルキル硫酸トリエタノールアミン 18.0部 2.ラウリン酸ジエタノールアミド 3.0 3.テオフィリン 0.1 4.メチルセルロース 0.5 5.精製水 77.0 6.香料 適量 ［製法］成分4に成分5を均一に融解した後、成分1およ
び3を加え、70〜75゜Cで加熱溶解した後、成分2を加え、
冷却途上に成分6を加え30゜Cまで冷却しシャンプーとす
る。Example-3 Shampoo 1. Alkyl sulfate triethanolamine 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Theophylline 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Fragrance [Producing method] Component 4 to component 5 After melting uniformly, add components 1 and 3, heat and dissolve at 70-75 ° C, then add component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.
【００１０】実施例−４ リンス ［製法］成分1〜8を60゜Cで溶解し、攪拌して30゜Cまで冷
却しリンスとする。Example-4 Rinse [Production method] Ingredients 1 to 8 are dissolved at 60 ° C, stirred and cooled to 30 ° C for rinsing.
【００１１】[0011]
【発明の効果】本発明の育毛剤は、優れた育毛効果を有
し、男性型脱毛症および老人性脱毛症を含む多くの脱毛
症に有効なものである。INDUSTRIAL APPLICABILITY The hair-growing agent of the present invention has an excellent hair-growing effect and is effective for many alopecia including androgenetic alopecia and senile alopecia.
【００１２】[0012]
【実験例】つぎに、本発明の効果を詳細に説明するた
め、実験例を挙げる。 実験例−１ マウスに対する育毛効果 3週齢ICR系雄性マウスの背部毛を皮膚に損傷を与えない
ように注意深く毛刈および剃毛し、これらのマウスを12
匹ずつ2群に分け、1群にテオフィリンを2%含有する80%
エタノール溶液を、またもう1群には対照としての80%エ
タノール溶液を1日2回、1回につき約0.5mlそれぞれ塗布
した。判定は剃毛部における再生毛の認められた面積を
測定することにより行い、下記の式に従って再生率を算
出した。 EXPERIMENTAL EXAMPLE Next, an experimental example will be given in order to explain the effect of the present invention in detail. Experimental Example-1 Hair-growth effect on mice 3-week-old ICR male mice were carefully shaved and shaved so as not to damage the skin.
Each animal is divided into 2 groups, 1 group contains 2% theophylline 80%
An ethanol solution was applied to the other group, and an 80% ethanol solution as a control was applied to the other group twice a day, and about 0.5 ml each time. The judgment was performed by measuring the area where the regenerated hair was observed in the shaved portion, and the regeneration rate was calculated according to the following formula.
【００１３】[0013]
【表１】 試料塗布開始後、23日目、26日目、29日目、32日目およ
び35日目の各群における再生率を求めた結果を表１に示
したが、テオフィリンは対照と比較した場合、毛の再生
を明らかに速め、顕著な発毛促進効果が認められた。[Table 1] The results of the regeneration rate in each group on the 23rd, 26th, 29th, 32nd and 35th day after the start of application of the sample are shown in Table 1. Theophylline was compared with the control. The hair regrowth was clearly accelerated, and a remarkable hair growth promoting effect was observed.
【００１４】実験例−２ ヒトに対する育毛効果 脱毛に悩む男性15人に対し、実施例−２のヘアトニック
を3ヶ月間毎日1回塗布の使用テストを実施したところ、
7人に有効、6人にやや有効の結果が得られ、かつ皮膚に
異常は見られなかった。本発明の育毛剤は人に対しても
有効であり、かつ皮膚刺激のないことを確認した。Experimental Example-2 Hair growth effect on humans When 15 men suffering from hair loss were subjected to a use test of applying the hair tonic of Example-2 once a day for 3 months,
The results were good for 7 people and slightly good for 6, and no abnormalities were observed on the skin. It was confirmed that the hair restorer of the present invention is effective for humans and has no skin irritation.
Claims (1)
毛剤。1. The following general formula (1): A hair-growing agent characterized by containing theophylline represented by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20608992A JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20608992A JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0624943A true JPH0624943A (en) | 1994-02-01 |
| JP3205601B2 JP3205601B2 (en) | 2001-09-04 |
Family
ID=16517635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20608992A Expired - Lifetime JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3205601B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1829523A1 (en) * | 2006-03-01 | 2007-09-05 | L'oreal | Cosmetic use of an N-oxide derivative of theophylline |
| WO2008028773A1 (en) * | 2006-09-06 | 2008-03-13 | Henkel Ag & Co. Kgaa | Agents containing bioquinone and purine or purine derivatives |
| EP1970046A1 (en) * | 2007-03-15 | 2008-09-17 | Henkel AG & Co. KGaA | Use of purine and purine derivatives for treating hair |
| JP2009545633A (en) * | 2006-08-30 | 2009-12-24 | ザ プロクター アンド ギャンブル カンパニー | Hair care composition that can improve the appearance of darker and richer hair |
-
1992
- 1992-07-09 JP JP20608992A patent/JP3205601B2/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1829523A1 (en) * | 2006-03-01 | 2007-09-05 | L'oreal | Cosmetic use of an N-oxide derivative of theophylline |
| FR2898048A1 (en) * | 2006-03-01 | 2007-09-07 | Oreal | COSMETIC USE OF THEOPHYLLINE N-OXIDE DERIVATIVE |
| JP2009545633A (en) * | 2006-08-30 | 2009-12-24 | ザ プロクター アンド ギャンブル カンパニー | Hair care composition that can improve the appearance of darker and richer hair |
| WO2008028773A1 (en) * | 2006-09-06 | 2008-03-13 | Henkel Ag & Co. Kgaa | Agents containing bioquinone and purine or purine derivatives |
| EP1970046A1 (en) * | 2007-03-15 | 2008-09-17 | Henkel AG & Co. KGaA | Use of purine and purine derivatives for treating hair |
| DE102007013143A1 (en) * | 2007-03-15 | 2008-10-02 | Henkel Ag & Co. Kgaa | Use of purine and purine derivatives for hair treatment |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3205601B2 (en) | 2001-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH07316023A (en) | Hair tonic | |
| JP2676154B2 (en) | Hair restoration | |
| JPH0238564B2 (en) | ||
| EP1426034B1 (en) | Hair growth tonic | |
| JPH026403A (en) | Cosmetic for hair and hair tonic | |
| JP2676155B2 (en) | Hair restoration | |
| JPH0624943A (en) | Hair-growing agent | |
| WO1989002731A1 (en) | Hair tonic | |
| JP2001288048A (en) | Composition for scalp and hair | |
| JP2546813B2 (en) | Hair nourishing cosmetics | |
| JP3522388B2 (en) | Hair growth agent | |
| JPH11302133A (en) | Cosmetic for scalp and hair | |
| JPH04305517A (en) | Hair care cosmetics | |
| JPH07206647A (en) | Hair tonic | |
| JPH11322545A (en) | Cosmetic for scalp and hair | |
| JP3624318B2 (en) | Hair nourishing agent | |
| EP0679385A2 (en) | Hair revitalizing composition | |
| JP3948684B2 (en) | Cosmetics | |
| JP2000016920A (en) | Hair tonic cosmetic | |
| JPH09227342A (en) | Hair-tonic and hair-growing agent | |
| JPH026404A (en) | Cosmetic for hair and hair tonic | |
| JPH0227965B2 (en) | YOMORYO | |
| JPH07149614A (en) | Hair tonic agent | |
| JPH04308523A (en) | Hair-tonic cosmetic | |
| JPS62190116A (en) | Hair-tonic cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |