JPH0227965B2 - YOMORYO - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a hair nourishing agent. More specifically, the present invention relates to a hair nourishment for animals including humans, which has an excellent hair growth effect and is made by incorporating pantetheine-S-sulfonic acid and/or its salt into an external preparation or a hair base. It is something. BACKGROUND OF THE INVENTION As stress increases and social conditions become more complex, the number of people suffering from various types of hair loss such as alopecia areata and puberty alopecia has recently increased.
Once a person suffers from such alopecia, the symptoms become obvious to the public, making the patient even more nervous, and the recovery is delayed for a long time, causing neurological pain, especially It's unbearable. A large number of compounds have been used for the prevention and treatment of such alopecia. For example, various vitamins, amino acids, hormones, vasodilators,
Although crude drug extracts and the like have been tried or commercialized, there is nothing definitive, and the current situation is that it takes several months to several years to treat alopecia. Therefore, it has been an urgent technical challenge in the industry to establish an excellent hair nourishing agent to replace these materials. In order to solve these problems, we screened a large number of organic and inorganic substances, compounds with known and unknown structures, not only from the cosmetics field, but also from other pharmaceutical and industrial chemical fields, and as a result, we found pantothenic acid-based substances. I came to focus on
As a result of further investigation, they obtained a new finding that pantetheine-S-sulfonic acid has a remarkable effect on hair nourishment and hair growth, which provided the basis for completing the present invention. Pantetheine-S-sulfonic acid or a salt thereof is a known compound represented by the following formula. (In the formula, M represents hydrogen, an alkali metal, or a 1/2 alkaline earth metal.) Pantetheine-S-sulfonic acid and its salts are coenzyme A, which plays an important role in energy metabolism, lipid metabolism, and acetylation in the body. It is known that it is a useful compound as a precursor for [Japan.J.Microbiol.vol.16(3), 239-
242 (1972)] There is no knowledge of its use as a hair nourishing agent. Since this compound can now be easily produced in large quantities from, for example, D-pantothenic acid and 2-aminoethanethiol sulfuric acid, problems related to the supply of active ingredients have also been resolved. In addition, as is clear from the test examples described below, pantetheine-S-sulfonic acid and its salts not only have extremely excellent hair growth and nourishing effects, but also have favorable properties from the viewpoint of skin and hair science, such as moisturizing effects and tissue revitalizing effects. It is also owned. In addition, the toxicity data is 10g/Kg or more when administered orally to rats, indicating that it is non-toxic. Furthermore, since it is an odorless powder and has excellent stability, it also has the characteristics of being extremely easy to handle in terms of formulation. Furthermore, the hair nourishment according to the present invention is not only effective for humans, but also exhibits remarkable effects on hair growth and hair cultivation in other animals. For example, this applies to fur collecting animals such as foxes, mink, rabbits, martens, weasels, stoats, chinchillas, raccoon dogs, lambs, woolly collecting animals such as sheep and alpacas, and various other pet animals. It has been confirmed that when used, it promotes hair growth and improves the color of hair, making it an extremely excellent hair nourishment for animals. The present invention has been completed based on such new findings, and relates to a hair nourishment for humans or other animals that is characterized by containing pantetheine-S-sulfonic acid and/or its salt. be. Pantetheine, the active ingredient in the present invention
When S-sulfonic acid and/or its salts are incorporated into hair/cosmetic bases, they may be used alone or in combination, and as is clear from the test examples below, they may be used together with other hair nourishing agents. It also has the characteristic of producing a synergistic effect when used.
Although these are used as hair nourishing agents, they are not limited in any way by the base material used. Therefore, ethanol, animal and vegetable fats (oils), higher alcohols, glycols, surfactants, pigments, fragrances, stabilizers and other ingredients that are generally used as base materials for hair cosmetics can be used freely. There is no particular restriction on the amount used, but it is usually preferable to mix it in an amount of 0.1% or more. The hair nourishment according to the present invention can be applied in an appropriate amount to the affected area, and there are no particular problems when using it.
This point is also one of the advantages of the present invention. In preparing the hair nourishment according to the present invention, methods commonly used in the technical field may be used as appropriate, such as simply mixing and dissolving the active ingredients and auxiliary ingredients, or adding a heating treatment to the mixture. be done. Next, we will discuss Test Example 1 that demonstrates that pantetheine-S-sulfonic acid and/or its salt exhibits a hair-growth effect, and that pantetheine-S-sulfonic acid and/or its salt exhibits a hair-growth effect compared to other hair nourishing agents. Test Example 2 will be described to demonstrate that when used in combination, they exhibit a very excellent synergistic effect. Thereafter, embodiments of the present invention will be described in detail. Test example 1 Vitamin E, panthenol, pantethein-S
-The hair growth and hair growth effects of calcium sulfonate were investigated using mice. Five-week-old DDY male mice (manufactured by Tokyo Experimental Animals Co., Ltd.) were used in the experiment, and were kept with free access to food (CE-2, Nippon Flare Co., Ltd.) and tap water for 4 days before the start of the experiment. Those in good condition were selected and used for experiments. A group of 9 mice was used, and the hair was removed from two places on the back with ophthalmic scissors, and the hair was completely removed using hair removal cream (Evaclaim S, Tokyo Tanabe Pharmaceutical Co., Ltd.).
After leaving it in the sun, dissolve the drug in 50% ethanol to a concentration of 10% and apply it to one hair removal area, and apply 50% ethanol to the other side once a day as a control.
It was applied once for 2 weeks. After completion of administration, remove hair from the hair removal area.
Approximately 50 hairs are randomly pulled out, 10 of which are in descending order of length.
The hair length of the book was measured using calipers. The results are shown in Table 1.

[Table] As a result, there was a significant difference in hair length between the control site and the drug application site of one individual in the group (indicated by the number of effective cases in the table), and in the vitamin E treatment group, 7 out of 9 cases showed a significant difference in hair length. ,
This was 5 out of 9 cases in the panthenol administration group, and 8 out of 9 cases in the pantetheine-S-calcium sulfonate administration group. Therefore, the order of strength of action was pantetheine-S-calcium sulfonate>vitamin E>panthenol. These results revealed that calcium pantetheine-S-sulfonate has a hair-growth and hair-growth effect, and also exhibits a strong hair-growth and hair-growth activity when administered for a long period of time. Test Example 2 The synergistic effects of 5% calcium pantetheine-S-sulfonate on 10% carpronium chloride and 10% vitamin E were investigated. The administration period is 2
The experimental method was the same as in Test Example 1. The results are shown in Table 2.

[Table] As is clear from the above results, the mixed administration group of 5% pantetheine-S-calcium sulfonate and 10% carpronium chloride showed particularly high values compared to the single administration group. It is clearly observed that calcium pantetheine-S-sulfonate has a synergistic effect. It was also found that vitamin E had a similar synergistic effect. In the experimental system containing carpronium chloride, there were cases where mice licked the drug solution at the application site and caused problems, so the experiment was conducted by covering the application site with breathable tape for all groups. In addition, it was found that the hair sheathing of the areas to which pantetheine-S-calcium sulfonate was applied was extremely good compared to other areas, which was commonly observed in all tests. Therefore, it can be seen that the hair nourishment according to the present invention not only physically lengthens hair, but also has the effect of improving hair quality. Next, Examples of the hair nourishment according to the present invention will be shown, and the numerical values in the examples represent weight % unless otherwise specified. Example 1 Hair tonic 1 Ethanol 60 ml 2 Vegetable oil 0.5 3 Propylene glycol 5 4 Calcium pantetheine-S-sulfonate 5 5 Purified water Add to make 100 ml. The above ingredients are mixed and dissolved to form a product. Example 2 Hair tonic 1 Ethanol 60ml 2 Vegetable oil 0.5 3 Propylene glycol 5 4 Carpronium chloride 0.5 5 Calcium pantetheine-S-sulfonate 2 6 Purified water Add to make 100ml. The above ingredients are mixed and dissolved to form a product. Example 3 Hair lotion 1 Stearic acid 5 2 Setanol 0.5 3 Aracel 83 1 4 Triethanolamine 0.4 5 Glycerin 5 6 Tocopherol acetate 0.01 7 Capsicum tincture 3 ml 8 Calcium pantetheine-S-sulfonate 2 9 Preservative, fragrance Appropriate amount 10 Purification Add water to make 100ml. It is produced by heating and melting 1 to 3 to 70 to 80°C, adding 4 to 10 at the same temperature, and cooling while stirring. Example 4 Hair shampoo 1 Sodium lauryl ether sulfate 20 2 Sodium lauryl sulfate 10 3 Lauric acid diethanolamide 5 4 Propylene glycol 2 5 Jasperia japonica extract 0.1 6 Sodium pantetheine-S-sulfonate 5 7 Preservatives, pigments, fragrances Appropriate amount 8 Purified water Add 100ml. The above ingredients are mixed and dissolved to form a product. Example 5 Hair cream 1 Vaseline 2.5 2 Liquid paraffin 10 3 Cetostearyl alcohol 12 4 Polyoxyethylene sorbitan monostearate 7 5 Sorbitan monostearate 1 6 Propylene glycol 5 7 Panthenol 1 8 Pantetheine-S-calcium sulfonate 3 9 Add appropriate amount of preservatives and fragrance 10 Purified water to make the total amount 100g. The oil layers 1 to 5 and the aqueous layers 6 to 10 are respectively heated to 75°C, emulsified, and then cooled while stirring.

Claims (1)

[Claims] 1. A hair tonic characterized by containing pantetheine-S-sulfonic acid and/or a salt thereof represented by the formula (wherein M represents hydrogen, an alkali metal or a 1/2 alkaline earth metal).