CN108379124A - Essential oils and its preparation method and application for preventing and repairing skin barrier damage - Google Patents
Essential oils and its preparation method and application for preventing and repairing skin barrier damage Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/005—Preparations for sensitive skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Camellia seed oil 1.0 50%, vegetable fat 2.0 20%, agent 0.5 5% of releiving, stabilizer 0.05 5%, surplus are Synthetic Oil.The essential oils of the present invention are rich in multiple efficacies ingredient, are reconciled mutually between each ingredient, act synergistically, and can prevent the damage of skin barrier, promote the reparation process of skin barrier damage, have good antiallergic effect to the sensitive skin of skin barrier function exception；In addition, the essential oils of the present invention do not add emulsifier, perfume ingredient, added burden will not be caused to skin.
Description
Technical field
The invention belongs to technical field of skin care, and in particular to a kind of essence for preventing and repairing skin barrier damage
Oil and its preparation method and application.
Background technology
With the improvement of living standards, people increasingly pay close attention to the nursing of skin, the especially nursing of skin of face.It safeguards
The normal barrier function of skin is basis and the important component of skin nursing.Hormonal readiness fluctuation, stress, extraneous thorn
Swash, ultraviolet light, the internal and external factors such as environmental pollution can all cause different degrees of skin barrier structure and function abnormal, it is serious very
To leading to the impaired of skin barrier function, and it is one of an important factor for leading to various skin diseases that skin barrier function is impaired.
Facial cuticle thickness is relatively thin, easily occur to environmental stimuli it is sensitive, the skin barriers unusual condition such as do not tolerate, it is therefore desirable to more
Pay attention to preventing the damage of skin of face barrier function, once impaired also to take timely measure of skin barrier, which occurs, restores barrier work(
Energy.The prior art has reported effect of the ceramide in skin barrier reparation, but some researches show that ceramide mainly exists
The later stage of skin barrier reparation plays a role (Wu Jinyan, Jiang Xian, ceramide and skin barrier, Chinese skin cypridology magazine
[J],2011,25(1):64-65.).And so far, it there are no pre- about being carried out to skin barrier damage using effect object
The report of anti-aspect.
Camellia seed oil, also name tea oil, camellia oil, tea-seed oil, tea-seed oil etc., are rich in unsaturated fatty acid, tea polyphenols, spiny dogfish
The nutriments such as alkene, vitamin E, zinc, nutritive value can compare favourably with olive oil, thus by laudatory title be " olive oil in east " and
" magical east oil ".Camellia is the distinctive woody oil tree species of southern region of China, there is very long cultivation history.In view of
The unique growing environment of camellia, the distinctive ingredient of woody oleiferous plants and effect, camellia seed oil have splendid cosmetic applications value.With
Cosmetics commonly compare by high-grade grease, and camellia seed oil is in the also great potential excellent of skin sense, both effectiveness, safety etc.
Gesture.The Camellia kissii seed oil of Camellia, camellia seed oil, tea-seed oil and camellia seed oil are also very much like in ingredient, effect etc..
The research of Camellia seed oil is stressed in edible health, moist, anti-oxidant, whitening and anti-aging etc. more at present, for
Camellia seed oil is in skin barrier damage prevention, the research repaired also in blank stage.
Although in the market there is also some be used for repair skin barrier damage skin care item, these skin care item generally for
Improve some aspects the effect of, it will usually add the ingredients such as preservative, emulsifier, essence, hormone and surfactant, these at
Branch generates added burden to skin.CN105997625A discloses a kind of moist breast for child skin mucous membrane operational maintenance
And its apply, containing surfactant A PG and preservative lysozyme or antibacterial peptide in ingredient, it is unnecessary that skin is caused
Burden.Therefore, it is necessary to develop a kind of preventions for not adding the ingredients such as emulsifier, perfume ingredient to damage with skin barrier is repaired,
Alleviate the essential oils of skin sensitivity situation.
Invention content
In view of the deficiencies of the prior art, the object of the present invention is to provide a kind of for preventing and repairing skin barrier damage
Essential oils.The essential oils of the present invention are rich in multiple efficacies ingredient, are reconciled mutually between each ingredient, act synergistically, can prevent
The damage of skin barrier promotes the reparation process of skin barrier damage, has for the sensitive skin of skin barrier function exception
Good antiallergic effect.In addition, the essential oils of the present invention do not add emulsifier, perfume ingredient, additional negative will not be generated to skin
Load.
The technical solution adopted by the present invention is：A kind of essential oils for preventing and repairing skin barrier damage, by weight
Percentages, including following components：It is Camellia seed oil 1.0-50%, vegetable fat 2.0-20%, the agent 0.5-5% that releives, steady
Determine agent 0.05-5%, surplus is Synthetic Oil.It is furthermore preferred that the essential oils for preventing and repairing skin barrier damage, by weight
Measure percentages, including following components：Camellia seed oil 5-40%, vegetable fat 5-15%, releive agent 1-5%, stabilizer
0.1-4%, surplus are Synthetic Oil；It is further preferred that the essential oils for preventing and repairing skin barrier damage, by weight
Percentages, including following components：Camellia seed oil 10-30%, vegetable fat 8-12%, the agent 2-4% that releives, stabilizer 1-
3%, surplus is Synthetic Oil.
Preferably, the Camellia seed oil is in Camellia kissii seed oil, camellia seed oil, camellia seed oil, tea-seed oil
It is one or more.
Preferably, the vegetable fat is selected from wheat-germ oil, hippophae rhamnoides fruit oil, olive oil, apricot kernel oil, green bur
The auspicious palmitic acid fruit oil of oil, Prunus Amygdalus Dulcis Oil, bitter orange flower oil, sweet orange peel oil, jojoba seed oil, hair, avocado oil, Wild soybean oil and Australia are hard
It is one or more in fruit seed oil.
Preferably, the agent of releiving is selected from defensil, german chamomile flower extract, pot marigold extract, bisabolol, accumulated snow
It is one or more in careless glycosides, fragrant quick easypro and licoflavone.
Preferably, the stabilizer is selected from tocopherol acetate, Rosmarinus officinalis extract, BHT, methoxy cinnamic acid ethyl hexyl
One kind in ester, benzotriazole base dodecyl p- cresols, methylene bis-benzotriazolyl tetramethyl butyl phenol and Co-Q10
Or it is a variety of.
Preferably, the Synthetic Oil is selected from ethylhexyl palmitate, lauric alcohol-caprylate/decylate, hydrogenated olive oil
It is one or more in decyl alcohol esters, carbonic acid dioctyl ester, saualane, ceramide and caprylic/capric glyceride.
The present invention also provides the preparation methods of the essential oils for preventing and repairing skin barrier damage, including following step
Suddenly：
1) Synthetic Oil and stabilizer are added into reactor, is warming up to 55~60 DEG C, is stirred；
2) 40~45 DEG C are cooled to, vegetable fat, stirring is added；
3) be cooled to room temperature, sequentially add Camellia seed oil and releive agent, stirring, filtering to get to for prevent with
Repair the essential oils of skin barrier damage.
Preferably, in step 1), the rotating speed being stirred is 200-300rpm, and mixing time is 3-5min；In step 2),
The rotating speed being stirred is 200-300rpm, and mixing time is 5-10min；In step 3), the rotating speed being stirred is 200-
300rpm, mixing time are 5-10min.
More specifically, the preparation method of the essential oils for preventing and repairing skin barrier damage is：In 200~300rpm
Under rotating speed stirring, Synthetic Oil and stabilizer are added into reactor, is warming up to 55~60 DEG C, is stirred 3~5min, cools down
To 40~45 DEG C, be added vegetable fat, stir evenly 5~10min, continue to be cooled to room temperature, sequentially add Camellia seed oil,
It releives agent, is stirred 5~10min in 200~300rpm rotating speeds, filtering is to get to for preventing and repairing skin barrier damage
The essential oils of wound.
The present invention also provides for prevent and repair skin barrier damage essential oils skin barrier damage prevent and
Application in the cosmetics of reparation.
It is furthermore preferred that can be different applied to skin barrier function by the essential oils for preventing and repairing skin barrier damage
In normal sensitive skin, it is used as antiallergic cosmetics.
The present invention also provides the essential oils for preventing and repairing skin barrier damage are weaker in skin barrier function
Application in the cosmetics of crowd.
It is furthermore preferred that can by for prevent and repair skin barrier damage essential oils be applied to skin-care products for infant or
In cosmetics.
The beneficial effects of the invention are as follows：The essential oils of the present invention are rich in multiple efficacies ingredient, and Camellia seed oil contains tea
Polyphenol, monounsaturated fatty acids glyceride, phytosterol and saponin component are releived with anti-inflammatory, supplement skin lipid and rush
The effect of restoring into skin barrier；Vegetable fat can supplement skin lipid, restore skin water and oil balance and enhancing skin barrier；
Agent of releiving can improve the impaired caused condition responsive of barrier；Stabilizer enhance skin it is anti-oxidant and absorb ultraviolet light, help
Skin resists the injury of the injurious factors such as ultraviolet light, while improving stability of the product to photo-thermal；Synthetic Oil is in skin surface
Form protective film.It reconciles mutually, acts synergistically between each ingredient, the damage of skin barrier can be prevented, promote skin barrier
The reparation process of damage has good antiallergic effect to the sensitive skin of skin barrier function exception；In addition, the essence of the present invention
Magnificent oil does not add emulsifier, perfume ingredient, will not cause added burden to skin.
Specific implementation mode
Below by way of specific embodiment come the present invention is further illustrated, but these embodiments simply to illustrate that,
It is not limitation of the present invention.
Embodiment 1
A kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Mountain
Camellia seed oil 5%, vegetable fat 14%, agent 1.15% of releiving, stabilizer 2.45% and Synthetic Oil 77.4%.
Wherein, Camellia seed oil is selected from camellia seed oil；Vegetable fat is selected from apricot kernel oil, wheat-germ oil and Mao Rui palmitic acid fruits
Oil；Agent of releiving be selected from defensil and it is fragrant it is quick relax；Stabilizer is selected from BHT, tocopherol acetate and methoxy cinnamic acid ethyl hexyl
Ester；Synthetic Oil is selected from ethylhexyl palmitate.
The preparation method of essential oils for preventing and repairing skin barrier damage is：Under the stirring of 200rpm rotating speeds, to
77.4% ethylhexyl palmitate, 0.05%BHT, 2.0% tocopherol acetate, 0.4% methoxycinnamate are added in reactor
Sour ethylhexyl is warming up to 55 DEG C, is stirred 3min, is cooled to 40 DEG C, and 6.0% apricot kernel oil, 6.0% wheat embryo is added
Oil, 2.0% mao of auspicious palmitic acid fruit oil, stir evenly 5min, continue to be cooled to room temperature, sequentially add 5.0% camellia seed oil, 1.0%
Defensil, 0.15% it is fragrant it is quick relax, be stirred 5min under 300rpm rotating speeds, filter to get to for preventing and repairing skin
The essential oils of skin barrier injury.
Embodiment 2
A kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Mountain
Camellia seed oil 1%, vegetable fat 12%, agent 0.5% of releiving, stabilizer 4.6%, Synthetic Oil 81.9%.
Wherein, Camellia seed oil is selected from Camellia kissii seed oil；Vegetable fat is selected from olive oil, prinsepia utilis royle oil, sand
Spine fruit oil；Agent of releiving is selected from bisabolol；Stabilizer is selected from BHT, tocopherol acetate and benzotriazole base dodecyl p- first
Phenol；Synthetic Oil is selected from ethylhexyl palmitate.
Under the stirring of 300rpm rotating speeds, 81.9% ethylhexyl palmitate, 0.1%BHT, 4.0% are added into reactor
Tocopherol acetate, 0.5% benzotriazole base dodecyl p- cresols, are warming up to 60 DEG C, are stirred 5min, be cooled to 45
DEG C, 6.0% olive oil, 5.0% prinsepia utilis royle oil, 1.0% hippophae rhamnoides fruit oil is added, stirs evenly 10min, continues to be cooled to room
Temperature sequentially adds 1% Camellia kissii seed oil, 0.5% bisabolol, 10min is stirred under 200rpm rotating speeds, is filtered, i.e.,
Obtain the essential oils for preventing and repairing skin barrier damage.
Embodiment 3
A kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Mountain
Camellia seed oil 10%, vegetable fat 14%, agent 2% of releiving, stabilizer 4.7%, Synthetic Oil 69.3%.
Wherein, Camellia seed oil is selected from tea-seed oil；Vegetable fat is selected from olive oil, bitter orange flower oil, sweet orange pericarp
Oil, jojoba seed oil and Prunus Amygdalus Dulcis Oil；Agent of releiving is selected from german chamomile flower extract and pot marigold flower extract；Stabilizer be selected from BHT,
Tocopherol acetate and ethylhexyl methoxy cinnamate；Synthetic Oil be selected from ethylhexyl palmitate and lauric alcohol-caprylate/
Decylate.
Under the stirring of 250rpm rotating speeds, 39% ethylhexyl palmitate, 30.3% lauric alcohol-octanoic acid are added into reactor
Ester/decylate, 0.1%BHT, 4.0% tocopherol acetate, 0.6% ethylhexyl methoxy cinnamate, are warming up to 55 DEG C, stir
Mixing 5min is mixed, is cooled to 45 DEG C, 6.0% olive oil, 4.0% bitter orange flower oil, 2.0% sweet orange peel oil, 1.0% is added
Jojoba seed oil, 1.0% Prunus Amygdalus Dulcis Oil stir evenly 10min, continue to be cooled to room temperature, sequentially add 10% tea-seed oil, 1% mother
Chrysanthemum extract, 1% pot marigold flower extract are stirred 5min in 250rpm rotating speeds, filter to get to for preventing and repairing
The essential oils of multiple skin barrier damage.
Embodiment 4
A kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Mountain
Camellia seed oil 50%, vegetable fat 10%, agent 1.15% of releiving, stabilizer 0.38%, Synthetic Oil 38.47%.
Wherein, Camellia seed oil is selected from tea-seed oil；Vegetable fat be selected from olive oil, Wild soybean oil, avocado oil and
Queensland nut seed oil；Agent of releiving be selected from licoflavone and it is fragrant it is quick relax；Stabilizer is selected from BHT and ethylhexyl methoxy cinnamate；
Synthetic Oil is selected from hydrogenated olive oil decyl alcohol esters, carbonic acid dioctyl ester, ceramide and saualane.
Under the stirring of 250rpm rotating speeds, it is pungent that 31% hydrogenated olive oil decyl alcohol esters, 5% carbonic acid two are added into reactor
Ester, 2% saualane, 0.47% ceramide, 0.3% ethylhexyl methoxy cinnamate, 0.08%BHT, are warming up to 55 DEG C, stir
Mixing 5min is mixed, is cooled to 45 DEG C, 6.0% olive oil, 2.0% Wild soybean oil, 1.0% avocado oil, 1.0% Australia is added
Nut seed oil stirs evenly 5min, continues to be cooled to room temperature, sequentially adds 50% tea-seed oil, 1% licoflavone, 0.15% fragrant quick
It relaxes, is stirred 10min in 300rpm rotating speeds, filters the essential oils for preventing and repairing to get skin barrier damage.
Embodiment 5
A kind of essential oils for preventing and repairing skin barrier damage, by weight percentage, including following components：Mountain
Camellia seed oil 20%, vegetable fat 8%, agent 1.15% of releiving, stabilizer 0.43%, Synthetic Oil 70.42%.
Wherein, Camellia seed oil is selected from tea-seed oil and camellia seed oil；Vegetable fat is selected from olive oil, prinsepia utilis royle oil
And wheat-germ oil；Agent of releiving be selected from asiaticosid and it is fragrant it is quick relax；Stabilizer is selected from Co-Q10 and Rosmarinus officinalis extract；Synthesis
Grease is selected from hydrogenated olive oil decyl alcohol esters, carbonic acid dioctyl ester and saualane.
Under the stirring of 300rpm rotating speeds, it is pungent that 32% hydrogenated olive oil decyl alcohol esters, 34% carbonic acid two are added into reactor
Ester, 4.42% saualane, 0.3% Co-Q10,0.13% Rosmarinus officinalis extract, are warming up to 60 DEG C, are stirred 3min, cooling
To 45 DEG C, 6.0% olive oil, 1.0% prinsepia utilis royle oil, 1.0% wheat-germ oil is added and stirs evenly 5min, continues to cool down
To room temperature, sequentially add 10% tea-seed oil, 10% camellia seed oil, 1% asiaticosid, 0.15% it is fragrant it is quick relax, in 300rpm rotating speeds
It is stirred 5min, filters to get to the essential oils for preventing and repairing skin barrier damage.
Comparative example 1
Under the stirring of 200rpm rotating speeds, 82.4% ethylhexyl palmitate, 0.05%BHT, 2.0% are added into reactor
Tocopherol acetate, 0.4% ethylhexyl methoxy cinnamate, are warming up to 55 DEG C, are stirred 3min, are cooled to 40 DEG C, add
Enter 6.0% apricot kernel oil, 6.0% wheat-germ oil, 2.0% mao of auspicious palmitic acid fruit oil, stirs evenly 5min, continue to be cooled to room temperature, according to
Secondary addition 1.0%defensil, 0.15% it is fragrant it is quick relax, be stirred 5min in 300rpm rotating speeds, filter to get without camellia seed
The control sample of oil.
1 barrier injury of test example prevents to evaluate with repairing effect
1, evaluation method
By the control sample of embodiment 1-5, comparative example 1 without camellia seed oil and pure camellia seed oil sample for testing.
It is selected in qualified 10 people of volunteer, completes experiment.Volunteer's age between 23 years old to 41 years old, average age 30.2 ± 5.94
Year.During experiment, it is bad anti-that subject does not occur the skin associated with sample on probation such as erythema, papule, wheal, itch
It answers.
At constant temperature (22 ± 1 DEG C), after the room of constant humidity (50 ± 5%) adapts to 30 minutes, the cuticula for first testing skin contains
Sample is pressed (2.0 ± 0.1) mg/cm by water and transepidermal water loss rate (TEWL)2Dosage is coated in volunteer's left hand inner forearm (4cm
× 4cm) and right forearm inside (4cm × 4cm), after being massaged into absorption, each position is stripped off 15 times with adhesive tape to cause skin screen
Barrier damage.Respectively before applying sample, adhesive tape strip off after 1 hour, 2 hours, 4 hours test skin water content of stratum corneum and warp
Transepidermal water loss rate (TEWL).It blank control (do not apply sample but equally stripped off with adhesive tape) while testing.
2, evaluation result
(1) evaluation result is indicated with water content of stratum corneum average value, is as a result listed in Table 1.
Essential oils, camellia seed oil and the blank control of the essential oils and comparative example 1 of 1 embodiment 1-5 of table
In the water content of stratum corneum % of different time
| Sample | 0h | 1h | 2h | 4h |
| 1 essential oils of embodiment | 19.7±8.8 | 41.5±10.7 | 40.8±9.5 | 40.5±9.4 |
| 2 essential oils of embodiment | 19.3±6.6 | 38.7±8.9 | 36.3±8.7 | 35.4±8.6 |
| 3 essential oils of embodiment | 18.6±7.8 | 39.5±9.5 | 37.3±10.5 | 36.3±12.8 |
| 4 essential oils of embodiment | 18.9±9.3 | 40.7±12.6 | 39.5±9.4 | 38.2±7.3 |
| 5 essential oils of embodiment | 18.2±8.7 | 41.1±10.4 | 38.1±11.3 | 37.6±9.5 |
| 1 sample of comparative example | 18.4±7.2 | 37.2±11.7 | 38.8±14.6 | 40.1±15.9 |
| Camellia seed oil | 19.2±9.7 | 33.4±9.4 | 32.3±10.2 | 31.1±10.6 |
| Blank control | 19.7±7.3 | 25.4±7.5 | 23.3±7.6 | 22.2±8.8 |
1 essential oils of comparing embodiment, 1 sample of comparative example and camellia seed oil as a result, it has been found that, it is aqueous for keratoderma
The raising of amount acts on, 1 essential oils of embodiment>1 sample of comparative example>Camellia seed oil>Blank control, the results showed that, in embodiment 1
On the basis of camellia seed oil replaced with into Synthetic Oil ethylhexyl palmitate, water content of stratum corneum reduces, and illustrates that camellia seed oil passes through
Cross the essential oils that compounding obtains has synergistic function in terms of skin barrier damage prevents with reparation.Table 1 the result shows that, it is real
The essential oils for applying a 2-5 also have the effect of skin barrier damage prevents and repairs.
(2) evaluation result is indicated with transepidermal water loss rate (TEWL) average value, is as a result listed in Table 2.
Essential oils, camellia seed oil and the blank control of the essential oils and comparative example 1 of 2 embodiment 1-5 of table
In the transepidermal water loss rate TEWL/% of different time
Transepidermal water loss rate (TEWL) is to judge one of main method of skin barrier function, the increasing of transepidermal water loss rate (TEWL)
Add it is considered that related to skin barrier function decline.The known problem skin being damaged in various skin barrier functions is (such as special
Answering property dermatitis, contact dermatitis etc.) in, the forfeiture of moisture from skin is more vigorous than healthy skin.
1 essential oils of comparing embodiment, 1 sample of comparative example and camellia seed oil as a result, it has been found that, for transepidermal water loss rate
(TEWL) reduction effect, 1 essential oils of embodiment>1 sample of comparative example>Camellia seed oil>Blank control, the results showed that, implementing
Camellia seed oil is replaced with into Synthetic Oil ethylhexyl palmitate on the basis of example 1, transepidermal water loss rate (TEWL) increases, and illustrates mountain
The essential oils that tea-seed oil is obtained by compounding have synergistic function in terms of skin barrier damage prevents with reparation.2 knot of table
Fruit shows that the essential oils of embodiment 2-5 also have the effect of skin barrier damage prevents and repairs.
In summary evaluation result reconciles mutually between each ingredient it is found that the essential oils of the present invention are rich in multiple efficacies ingredient,
Synergistic effect can prevent the damage of skin barrier, promote the reparation process of skin barrier damage, for skin barrier work(
Sensitive skin that can be abnormal has good antiallergic effect.
Test example 2 is releived antiallergic effect assessment
The volunteer of 20 sensitive skins is chosen, for the first time using the essential oils prepared by 1-5 of the embodiment of the present invention, is then filled out
Write effect questionnaire and description use feeling.Average result shows that 90% volunteer thinks that having dry skin tight situation obviously delays
Solution, 85% volunteer think that skin is releived, and 95% volunteer thinks to become smooth, moist using rear skin.It is all
Volunteer does not have any side effect or allergic phenomena occur.Thus provable, essential oils of the present invention have preferable relax
Slow antiallergic performance.
Claims (10)
1. a kind of essential oils for preventing and repairing skin barrier damage, which is characterized in that by weight percentage, including with
Lower component：It is Camellia seed oil 1.0-50%, vegetable fat 2.0-20%, the agent 0.5-5% that releives, stabilizer 0.05-5%, remaining
Amount is Synthetic Oil.
2. the essential oils according to claim 1 for preventing and repairing skin barrier damage, which is characterized in that the mountain
Camellia seed oil is one or more in Camellia kissii seed oil, camellia seed oil, camellia seed oil, tea-seed oil.
3. the essential oils according to claim 1 for preventing and repairing skin barrier damage, which is characterized in that the plant
Object grease is selected from wheat-germ oil, hippophae rhamnoides fruit oil, olive oil, apricot kernel oil, prinsepia utilis royle oil, Prunus Amygdalus Dulcis Oil, bitter orange flower oil, sweet tea
It is one or more in the auspicious palmitic acid fruit oil of orange peel oil, jojoba seed oil, hair, avocado oil, Wild soybean oil and Queensland nut seed oil.
4. the essential oils according to claim 1 for preventing and repairing skin barrier damage, which is characterized in that described to relax
Slow agent is selected from defensil, german chamomile flower extract, pot marigold extract, bisabolol, asiaticosid, fragrant quick easypro and licoflavone
In it is one or more.
5. the essential oils according to claim 1 for preventing and repairing skin barrier damage, which is characterized in that described steady
Determine agent and is selected from tocopherol acetate, Rosmarinus officinalis extract, BHT, ethylhexyl methoxy cinnamate, benzotriazole base dodecyl
It is one or more in p- cresols, methylene bis-benzotriazolyl tetramethyl butyl phenol and Co-Q10.
6. the essential oils according to claim 1 for preventing and repairing skin barrier damage, which is characterized in that the conjunction
At grease be selected from ethylhexyl palmitate, lauric alcohol-caprylate/decylate, hydrogenated olive oil decyl alcohol esters, carbonic acid dioctyl ester,
It is one or more in saualane, ceramide and caprylic/capric glyceride.
7. the preparation method of the essential oils for preventing and repairing skin barrier damage described in any one of claim 1-6,
It is characterized by comprising the following steps：
1) Synthetic Oil and stabilizer are added into reactor, is warming up to 55~60 DEG C, is stirred；
2) 40~45 DEG C are cooled to, vegetable fat, stirring is added；
3) it is cooled to room temperature, sequentially adds Camellia seed oil and agent of releiving, stirring is filtered to get to for preventing and repairing
The essential oils of skin barrier damage.
8. the essential oils for preventing and repairing skin barrier damage described in any one of claim 1-6 are damaged in skin barrier
Application in wound prevention and the cosmetics repaired.
9. the essential oils for preventing and repairing skin barrier damage described in any one of claim 1-6 are in skin barrier work(
Application in the antiallergic cosmetics of sensitive skin that can be abnormal.
10. the essential oils for preventing and repairing skin barrier damage described in any one of claim 1-6 are in skin barrier
Application in the cosmetics of the weaker crowd of function.
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| CN201810331060.XA CN108379124B (en) | 2018-04-13 | 2018-04-13 | Essential oil for preventing and repairing skin barrier damage and preparation method and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269929A (en) * | 2019-08-13 | 2019-09-24 | 滨海昌正企业管理有限公司 | Have effects that the composition of skin repair and its application in cosmetics |
| CN110801412A (en) * | 2019-12-04 | 2020-02-18 | 广州睿森生物科技有限公司 | Sebum bionic composition, application thereof and cosmetics |
| CN110960450A (en) * | 2019-12-31 | 2020-04-07 | 广州欧正化妆品技术研究院有限公司 | Full-oil facial essence for repairing sensitive muscles and preparation method thereof |
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| CN111557874A (en) * | 2020-04-29 | 2020-08-21 | 上海清轩生物科技有限公司 | Bionic skin barrier repairing composition containing camellia extract and application |
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| CN113768826A (en) * | 2021-09-15 | 2021-12-10 | 江苏苏美国际时尚管理有限公司 | Preparation method and application of essence |
| CN115068373A (en) * | 2022-06-16 | 2022-09-20 | 允斌(上海)健康科技有限公司 | Borneol-flavored scalp massage essential oil for head health care and preparation method thereof |
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| CN116236428A (en) * | 2023-03-02 | 2023-06-09 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening and moisturizing composition, emulsion and preparation method thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000021367A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | COMPOSITION BASED ON VITAMIN E FOR TOPICAL USE |
| IT202000021373A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | DERMO-COSMETIC COMPOSITION FOR TOPICAL USE |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326750A (en) * | 2015-11-25 | 2016-02-17 | 杨挺 | Special tea oil skincare lotion for pregnant women |
| CN105832615A (en) * | 2016-05-18 | 2016-08-10 | 广州丹奇日用化工厂有限公司 | Cleansing and removing two-in-one cleansing oil and preparation method thereof |
| CN106109305A (en) * | 2016-07-19 | 2016-11-16 | 上海清轩生物科技有限公司 | Moisturizing remediation composition containing Camellia oil and application thereof |
| CN106176444A (en) * | 2016-08-26 | 2016-12-07 | 天津天狮生物发展有限公司 | Skin nursing essential oils and preparation method thereof |
| CN107095804A (en) * | 2017-06-09 | 2017-08-29 | 中山大学附属第医院 | A kind of tea seed extraction oil skin cream and preparation method thereof |
| CN107281040A (en) * | 2017-07-28 | 2017-10-24 | 广州科缇生物科技有限公司 | A kind of maintenance essential oils for being directed to sensitive flesh and preparation method thereof |
| CN107854353A (en) * | 2017-11-02 | 2018-03-30 | 广州市美晟美容化妆品有限公司 | A kind of camellia skin-protection Essence and its preparation technology |
-
2018
- 2018-04-13 CN CN201810331060.XA patent/CN108379124B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326750A (en) * | 2015-11-25 | 2016-02-17 | 杨挺 | Special tea oil skincare lotion for pregnant women |
| CN105832615A (en) * | 2016-05-18 | 2016-08-10 | 广州丹奇日用化工厂有限公司 | Cleansing and removing two-in-one cleansing oil and preparation method thereof |
| CN106109305A (en) * | 2016-07-19 | 2016-11-16 | 上海清轩生物科技有限公司 | Moisturizing remediation composition containing Camellia oil and application thereof |
| CN106176444A (en) * | 2016-08-26 | 2016-12-07 | 天津天狮生物发展有限公司 | Skin nursing essential oils and preparation method thereof |
| CN107095804A (en) * | 2017-06-09 | 2017-08-29 | 中山大学附属第医院 | A kind of tea seed extraction oil skin cream and preparation method thereof |
| CN107281040A (en) * | 2017-07-28 | 2017-10-24 | 广州科缇生物科技有限公司 | A kind of maintenance essential oils for being directed to sensitive flesh and preparation method thereof |
| CN107854353A (en) * | 2017-11-02 | 2018-03-30 | 广州市美晟美容化妆品有限公司 | A kind of camellia skin-protection Essence and its preparation technology |
Non-Patent Citations (1)
| Title |
|---|
| 刘建才等: "化妆品级茶籽油功能性的应用研究", 《第一届中国个人护理品及原料学术研讨会暨中国天然植物化妆品产业发展论坛》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269929B (en) * | 2019-08-13 | 2021-11-02 | 昌正医疗(苏州)有限公司 | Composition with skin repairing effect and application thereof in cosmetics |
| CN110269929A (en) * | 2019-08-13 | 2019-09-24 | 滨海昌正企业管理有限公司 | Have effects that the composition of skin repair and its application in cosmetics |
| CN110801412A (en) * | 2019-12-04 | 2020-02-18 | 广州睿森生物科技有限公司 | Sebum bionic composition, application thereof and cosmetics |
| CN110801412B (en) * | 2019-12-04 | 2023-04-07 | 广州睿森生物科技有限公司 | Sebum bionic composition, application thereof and cosmetics |
| CN110960450A (en) * | 2019-12-31 | 2020-04-07 | 广州欧正化妆品技术研究院有限公司 | Full-oil facial essence for repairing sensitive muscles and preparation method thereof |
| CN111265433A (en) * | 2020-03-18 | 2020-06-12 | 广东袋鼠妈妈生物科技有限公司 | Infant skin moistening massage oil and preparation method and application thereof |
| CN111557874A (en) * | 2020-04-29 | 2020-08-21 | 上海清轩生物科技有限公司 | Bionic skin barrier repairing composition containing camellia extract and application |
| CN111616989A (en) * | 2020-06-23 | 2020-09-04 | 广州上官靖文化传播有限公司 | Repair emulsion capable of promoting skin regeneration and preparation method thereof |
| CN113768826A (en) * | 2021-09-15 | 2021-12-10 | 江苏苏美国际时尚管理有限公司 | Preparation method and application of essence |
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| CN116236428A (en) * | 2023-03-02 | 2023-06-09 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening and moisturizing composition, emulsion and preparation method thereof |
| CN116236428B (en) * | 2023-03-02 | 2024-01-23 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening and moisturizing composition, emulsion and preparation method thereof |
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