CN110269929A - Have effects that the composition of skin repair and its application in cosmetics - Google Patents
Have effects that the composition of skin repair and its application in cosmetics Download PDFInfo
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- CN110269929A CN110269929A CN201910745504.9A CN201910745504A CN110269929A CN 110269929 A CN110269929 A CN 110269929A CN 201910745504 A CN201910745504 A CN 201910745504A CN 110269929 A CN110269929 A CN 110269929A
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- composition
- skin
- skin repair
- effects
- cosmetics
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- 239000000203 mixture Substances 0.000 title claims abstract description 80
- 230000008439 repair process Effects 0.000 title claims abstract description 79
- 230000000694 effects Effects 0.000 title claims abstract description 51
- 239000002537 cosmetic Substances 0.000 title claims abstract description 29
- 239000002994 raw material Substances 0.000 claims abstract description 30
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 27
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 27
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 27
- 229940036350 bisabolol Drugs 0.000 claims abstract description 27
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000010495 camellia oil Substances 0.000 claims abstract description 25
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 claims abstract description 20
- 239000006071 cream Substances 0.000 claims description 13
- 239000000686 essence Substances 0.000 claims description 12
- 239000006210 lotion Substances 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 150000003254 radicals Chemical class 0.000 abstract description 8
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 230000002757 inflammatory effect Effects 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 230000005808 skin problem Effects 0.000 abstract description 5
- 238000001035 drying Methods 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 85
- 239000000523 sample Substances 0.000 description 15
- 230000000052 comparative effect Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 8
- 125000005908 glyceryl ester group Chemical group 0.000 description 7
- 239000010464 refined olive oil Substances 0.000 description 7
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 6
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 6
- 229940069521 aloe extract Drugs 0.000 description 6
- 229940106189 ceramide Drugs 0.000 description 6
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 6
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 6
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 230000008591 skin barrier function Effects 0.000 description 5
- OTEKOJQFKOIXMU-UHFFFAOYSA-N 1,4-bis(trichloromethyl)benzene Chemical compound ClC(Cl)(Cl)C1=CC=C(C(Cl)(Cl)Cl)C=C1 OTEKOJQFKOIXMU-UHFFFAOYSA-N 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 4
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000002000 scavenging effect Effects 0.000 description 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 208000001126 Keratosis Diseases 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- -1 can be 1% Chemical compound 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Have effects that the composition of skin repair and its application in cosmetics the present invention provides a kind of, it is related to skin repair technical field, this has effects that the composition of skin repair includes the raw material of following mass fraction: tea seed oil 20~60%, Cer EOS 0~60%, saualane 10~30%, bisabolol 1~10% and ginger-root extract 1~10%.This has effects that the composition of skin repair can effectively remove the free radical and inflammatory factor in skin, can effectively solve drying, itch, inflammation or the skin problems such as coarse.
Description
Technical field
The present invention relates to skin repair technical field, more particularly, to it is a kind of have effects that the composition of skin repair and its
Application in cosmetics.
Background technique
With the development of medicine and cosmetic science, people are increasingly clearly recognized that the key problem of skin nursing is exactly
The problem of barrier protection function of cuticula can preferably be maintained.When stratum corneum barrier function is stablized, skin will be shown
Good health status out.
Cuticula is located at the outermost layer of skin, and from physiological significance, cuticula is to prevent Skin Cell internal moisture
It loses, external microbe and chemical attacks provide extremely effective barrier action.But improperly skin caused by skin nursing
Skin inflammation etc. can all cause cuticula functional disturbance, generate the skin problems such as dry skin, itch, inflammation, coarse.At this point, such as
It is the imbalance that cannot change skin well that fruit, which only merely keeps the skin wet to skin,.
The method for solving the problems, such as cutaneous disorder at present can repair skin barrier, prevent scattering and disappearing for moisture, but cannot be well
The inflammatory factor generated in skin is removed, skin repair function is poor.
In view of this, the present invention is specifically proposed.
Summary of the invention
Has effects that the composition of skin repair the purpose of the present invention is to provide a kind of, the composition can be removed effectively
Free radical and inflammatory factor in skin can effectively solve drying, itch, inflammation or the skin problems such as coarse.
It is provided by the invention to have effects that the composition of skin repair, the raw material including following mass fraction: tea seed oil
20~60%, Cer EOS 0~60%, saualane 10~30%, bisabolol 1~10% and ginger-root extract 1~
10%.
Further, the raw material including following mass fraction: tea seed oil 20~50%, Cer NS 0~50%, angle
Shark alkane 10~20%, bisabolol 1~8% and ginger-root extract 1~8%.
Preferably, the composition with skin repair includes the raw material of following mass fraction: tea seed oil 30
~50%, Cer NS 0~40%, saualane 10~20%, bisabolol 3~8% and ginger-root extract 1~5%.
A kind of mentioned-above composition with skin repair is used for the drug or use of skin repair in preparation
Application in the cosmetics of skin repair.
A kind of mentioned-above preparation method with the composition of skin repair, comprising: each raw material is mixed, is obtained
Has effects that the composition of skin repair to described；
Preferably, each raw material is mixed under the conditions of 30~60 DEG C, obtains described having effects that the composition of skin repair.
A kind of drug for skin repair has effects that the composition of skin repair including mentioned-above.
A kind of cosmetics for skin repair have effects that the composition of skin repair including mentioned-above.
Further, the cosmetics include at least one of cream, lotion and essence.
Further, the cosmetics include cream, described to have effects that skin repair based on the gross mass of the cream
Composition content be 4-10wt%.
Further, the cosmetics include lotion, described to have effects that skin repair based on the gross mass of the lotion
Composition content be 3-7wt%.
Further, the cosmetics include essence, described to have skin repair based on the gross mass of the essence
The content of the composition of effect is 2-8wt%.
Compared with prior art, the present invention can at least obtain it is following the utility model has the advantages that
Linoleic acid, linolenic acid and ceramide in tea seed oil can form lipid layer close with human body, quickly form skin
Skin repairs barrier, in addition, the grease and saualane energy deep layer in tea seed oil moisturize the skin, and the dimension in tea seed oil is raw
Element, tea polyphenols isoreactivity ingredient and bisabolol and ginger-root extract are transported to inside skin, effectively remove oneself in skin
By base and inflammatory factor, achieve the purpose that quickly to repair skin barrier, the excellent effect of skin barrier is even repaired in maintenance, effectively
The balance for guaranteeing cutin layer function, can effectively solve the skin problems such as drying, itch, inflammation, coarse.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
In one aspect of the invention, has effects that the composition of skin repair the present invention provides a kind of, this has skin
The composition of skin maintenance effect includes the raw material of following mass fraction: tea seed oil 20~60% (such as can for 20%,
30%, 40%, 50% or 60% etc.), Cer EOS 0~60% (such as can be 10%, 20%, 30%, 40%, 50%
Perhaps 60% etc.) saualane 10~30% (such as can be 10%, 20% or 30% etc.), 1~10% (example of bisabolol
Such as can be 1%, 3%, 5%, 7% or 10%) and ginger-root extract 1~10% (such as can be 1%, 3%,
5%, 7% or 10% etc.).
Linoleic acid, linolenic acid and ceramide in tea seed oil can form lipid layer close with human body, quickly form skin
Skin repairs barrier, in addition, the grease and saualane energy deep layer in tea seed oil moisturize the skin, and the dimension in tea seed oil is raw
Element, tea polyphenols isoreactivity ingredient and bisabolol and ginger-root extract are transported to inside skin, effectively remove oneself in skin
By base and inflammatory factor, achieve the purpose that quickly to repair skin barrier, the excellent effect of skin barrier is even repaired in maintenance, effectively
The balance for guaranteeing cutin layer function, can effectively solve the skin problems such as drying, itch, inflammation, coarse.
Have effects that the content of each raw material in the composition of skin repair mutual cooperation effect in above-mentioned content range is excellent
It is different.When the mass content of tea seed oil is lower than 20%, then degree is moistened not enough, effective active composition practical function amount is on the low side, when
When the mass content of tea seed oil is higher than 60%, then skin sense is excessively greasy, is oxidized easily rancid etc..When the quality of ceramide
When content is lower than 10%, then practical function ingredient is on the low side, and effect expression is limited, when the mass content of ceramide is higher than 60%
When, then it is expensive, while system is it is possible that stability problem；It is when the mass content of saualane is lower than 10%, then whole
Body skin sense is partially greasy, poor permeability, protects insatiable hunger in grease and/or oxidizable component not enough, when the mass content of saualane is higher than
When 30%, then increased costs, quality is not docile enough, and it is not lasting enough to act on the percutaneous water loss of skin；When the matter of bisabolol
When measuring content lower than 1%, then it is lower than its effective action, it is when the mass content of bisabolol is higher than 10%, then whole greasy,
Permeability is absorbed to be obstructed；When the mass content of ginger-root extract is lower than 1%, then it is lower than the oxidation resistant effective dose of antibacterial, when
When the mass content of ginger-root extract is higher than 10%, then there may be additional irritation problems.
In some preferred embodiments of the invention, the composition with skin repair includes following quality
The raw material of score: tea seed oil 20~50%, Cer NS 0~50%, saualane 10~20%, bisabolol 1~8%, with
And ginger-root extract 1~8%.
In some more preferable embodiments of the invention, the composition with skin repair includes following matter
The raw material of amount score: tea seed oil 30~50%, Cer NS 0~40%, saualane 10~20%, bisabolol 3~8%,
And ginger-root extract 1~5%.
In another aspect of this invention, mentioned-above has effects that the composition of skin repair the present invention provides a kind of
In preparation for the application in the drug of skin repair or the cosmetics for skin repair.
In another aspect of this invention, mentioned-above has effects that the composition of skin repair the present invention provides a kind of
Preparation method, which includes: to mix each raw material, obtains described having effects that the composition of skin repair.
It in certain embodiments of the present invention, will under the conditions of 30~60 DEG C (such as 30 DEG C, 40 DEG C or 60 DEG C etc.)
The mixing of each raw material obtains described having effects that the composition of skin repair.Relative to above-mentioned temperature range, when mixing temperature is excessively high
When, then unsaturated ingredient is oxidized easily in camellia oil, and ginger-root extract is more easily damaged, and when mixing temperature is too low, is then held
Easy undercompounding, unevenly.
In another aspect of this invention, the present invention provides a kind of drug for skin repair, which includes front
Described has effects that the composition of skin repair.
It is understood that the dosage form of the drug can be ointment, liquid medicine or patch etc..
In another aspect of this invention, the present invention provides a kind of cosmetics for skin repair, which includes
It is mentioned-above to have effects that the composition of skin repair.
It is understood that above-mentioned cosmetics may include skin care item or color make-up etc..
In certain embodiments of the present invention, the cosmetics include at least one of cream, lotion and essence,
For example, the cosmetics may include cream, lotion or essence, it also may include two in cream, lotion and essence
Kind is two or more.
In certain embodiments of the present invention, the cosmetics include cream, described based on the gross mass of the cream
Have effects that the composition of skin repair content be 4-10wt% (such as can be 4wt%, 5wt%, 6wt%, 7wt%,
8wt%, 9wt% or 10% etc.).When the content of composition in cream is too low, then the active principle content pair in composition
It should reduce, directly affect antioxidant effect performance, when too high levels, then oily Phase Proportion increases, for system emulsifying capacity and stabilization
Property require it is higher, be easy to cause system demulsification layering, in addition for, skin sense can be greasy, and experience sense is bad.
In other embodiments of the invention, the cosmetics include lotion, based on the gross mass of the lotion, institute
State have effects that the composition of skin repair content be 3-7wt% (such as can be 3wt%, 4wt%, 5wt%, 6wt% or
Person 7wt% etc.).When the content of composition in lotion is too low, then the active principle content in composition is corresponding reduces, direct shadow
Antioxidant effect performance is rung, when too high levels, then emulsification is easy not exclusively, causes system stability bad.
In other embodiments of the invention, the cosmetics include essence, total matter based on the essence
Amount, the content with the composition of skin repair be 2-8wt% (such as can be 2wt%, 4wt%, 5wt%,
6wt% or 8wt% etc.).When the content of composition in essence is too low, then action intensity is inadequate, and effect is unobvious, content
When excessively high, then need to consider system stability problem.
Embodiment
Embodiment 1
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 30%, ceramide 40%, saualane 20%, bisabolol 5% and ginger-root extract 5%.
Embodiment 2
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 40%, Cer NP 4%, saualane 18%, bisabolol 5% and ginger-root extract 3%.
Embodiment 3
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 50%, Cer NP 0%, saualane 10%, bisabolol 8% and ginger-root extract 2%.
Embodiment 4
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 20%, Cer AP 0%, saualane 10%, bisabolol 8% and ginger-root extract 2%.
Embodiment 5
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 60%, Cer EOS 0%, saualane 10%, bisabolol 10% and ginger-root extract 10%.
Embodiment 6
The composition for having effects that skin repair includes the raw material of following mass fraction:
Tea seed oil 35%, ceramide 40%, saualane 15%, bisabolol 5% and ginger-root extract 5%.
Comparative example 1
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 10%, refined olive oil 70%, saualane 10%, bisabolol 8% and aloe
Extract 2%.
Comparative example 2
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 70%, refined olive oil 10%, saualane 10%, bisabolol 8% and aloe
Extract 2%.
Comparative example 3
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 10%, refined olive oil 60%, saualane 20%, bisabolol 8% and aloe
Extract 2%.
Comparative example 4
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 60%, refined olive oil 25%, saualane 5%, bisabolol 8% and aloe mention
Take object 2%.
Comparative example 5
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 30%, refined olive oil 25%, saualane 35%, bisabolol 8% and aloe
Extract 2%.
Comparative example 6
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 30%, refined olive oil 25%, saualane 28%, bisabolol 15% and aloe
Extract 2%.
Comparative example 7
The composition for having effects that skin repair includes the raw material of following mass fraction:
Caprylic/capric glyceryl ester 30%, refined olive oil 25%, saualane 22%, bisabolol 8% and aloe
Extract 15%.
The composition with skin repair in embodiment 1-6 and comparative example 1-7 is to be prepared by the following method
It obtains:
Each component is uniformly mixed in corresponding ratio in each embodiment and comparative example in 40 DEG C of condition respectively, respectively
It obtains composition ZH1 (corresponding embodiment 1), ZH2 (corresponding embodiment 2), ZH3 (corresponding embodiment 3) ... ZH7 (corresponding comparison
Example 1) ... ZH13 (corresponding comparative example 7).
Test example
Radicals scavenging experiment:
Radicals scavenging experiment is carried out by following method:
(1)2×10-4Preparation of the mol/L hexichol for bitter taste diazanyl (DPPH) solution: precise 0.0197g hexichol generation
Bitter taste diazanyl is dissolved in caprylic/capric triglyceride (GTCC), and constant volume, in 250mL volumetric flask, 5 DEG C are in store for；
The preparation of (2) 10% composition solutions: it takes 0.5mL composition ZH1 to be dissolved in the GTCC of 4.5mL respectively and prepares respectively
The composition solution that volume fraction is 10% obtains the ZH1 solution that volume fraction is 10% respectively, and 5 DEG C are in store for；
(3) taking diameter is 3, culture dish of 6cm, and label 1,2,3, takes 2 × 10 respectively-4Mol/L hexichol is for bitter taste diazanyl
(DPPH) solution 2mL accurately pipettes the prepared composition ZH1 solution of 2mL and is added in No. 1 culture dish in No. 1 culture dish,
It shakes up, is then sealed with sealing machine, react 20min in the dark, draw a part, measure light absorption value A at Yu Bochang 517nm1；
(4) 2 × 10 are taken-4Mol/L hexichol for bitter taste diazanyl (DPPH) solution 2mL in No. 2 culture dishes, accurately pipette
It is added in culture dish, shakes up with the GTCC of composition ZH1 solution even in (3), then by same operation described in (3), measure suction
Luminosity A2；
(5) GTCC2mL is added in No. 3 culture dishes, is equally operated by method described in (1), measures absorbance A3；
Clearance rate of the calculation composition ZH1 to free radical DPPH according to the following formula:
Identical method is tested according to above-mentioned radicals scavenging, the difference is that ZH1 is replaced with into ZH2-ZH13 respectively,
ZH2-ZH13 can be obtained respectively to the clearance rate of free radical DPPH, specifically, removing of the ZH1-ZH13 to free radical DPPH
Rate can be shown in Table 1:
Table 1
| Free radical scavenging activity/% | |
| ZH1 | 90 |
| ZH2 | 95 |
| ZH3 | 98 |
| ZH4 | 82 |
| ZH5 | 98 |
| ZH6 | 95 |
| ZH7 | 21 |
| ZH8 | 13 |
| ZH9 | 18 |
| ZH10 | 16 |
| ZH11 | 16 |
| ZH12 | 31 |
| ZH13 | 38 |
Apply to the composition ZH1-ZH13 with skin repair to carry out recruitment evaluation in skin cream, wherein group
Close object quality account for the 5% of skin cream gross mass respectively, wherein the cream without composition and containing composition it is specific
Visible the following table 2 is formed (wherein, to contain composition ZH1 in product B1, contain in sample B2 and contain in composition ZH2 ... sample B13
Composition ZH13):
Table 2
Wherein, in table 2 ZH1/ZH2/ZH3/ ... ZH13 indicate ZH1, ZH2, ZH3 ... or ZH13, B1/B2/
B3/ ... B13 indicate B1, B2, B3 ... or B13.
Moisture of skin tester (Multi Skin Test Center MC 750, German CK) test philosophy: since water has
There are very high dielectric constant, significantly larger than other substances, by test probe with after skin contact, the variation of capacitance (F) can
To reflect the water content in keratoderma, water content of stratum corneum is higher, and capacitance is also higher.It is all test constant temperature,
It is carried out in the laboratory of constant humidity, temperature (22 ± 1) DEG C, humidity (50 ± 5) %.
130 subjects of dry skin, the age 23~51 years old, average out to 40 years old, are divided into 13 groups.It is tested at every first
Person's both hands inner forearm respectively delimit two pieces of regions, be respectively labeled as No. 1 and No. 2 regions, with moisture of skin tester measure this two
The capacitance in block region.No. 1 and No. 2 region random process are respectively that sample A (smears sample twice daily by the 1st group of subject
A, 2mg/cm2), sample B1 (twice daily smear sample B1,2mg/cm2), the 2nd group of subject respectively by No. 1 and No. 2 regions with
Machine processing is that sample A (smears sample A, 2mg/cm twice daily2), sample B2 (twice daily smear sample B2,2mg/
cm2) ... No. 1 and No. 2 region random process are respectively that sample A (smears sample A, 2mg/ twice daily by the 13rd group of subject
cm2), sample B13 (twice daily smear sample B13,2mg/cm2), it is used continuously 10 days, measures skin moisture content daily.
1st group of subjects skin's moisture content test result (X ± S, n=10) see the table below 3:
Table 3
Skin moisture content test result (X ± S, n=40) at 2-13 group subject the tenth day see the table below 4:
Table 4
Wherein, the BN in table 4 is indicated: being B2 with the 2nd group of corresponding BN, is B3 ... and the 13rd with the 3rd group of corresponding BN
The corresponding BN of group is B13.
In the third day using B1-B13 product, the water content of the area skin is higher, with the region comparing difference for using A
Significantly, this template of explanation containing composition can be obviously improved the water content of keratoderma, i.e. the template containing composition has
Cuticula maintenance effect, it might even be possible to have the function that repair cuticula.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of have effects that the composition of skin repair, which is characterized in that the raw material including following mass fraction: tea seed oil
20~60%, Cer EOS 0~60%, saualane 10~30%, bisabolol 1~10% and ginger-root extract 1~
10%.
2. according to claim 1 have effects that the composition of skin repair, which is characterized in that including following mass fraction
Raw material: tea seed oil 20~50%, Cer NS 0~50%, saualane 10~20%, bisabolol 1~8%, Yi Jijiang
Root extract 1~8%；
Preferably, the composition with skin repair includes the raw material of following mass fraction: tea seed oil 30~
50%, Cer NS 0~40%, saualane 10~20%, bisabolol 3~8% and ginger-root extract 1~5%.
3. the drug that a kind of composition with skin repair of any of claims 1 or 2 is used for skin repair in preparation
Or for the application in the cosmetics of skin repair.
4. a kind of preparation method with the composition of skin repair of any of claims 1 or 2, which is characterized in that packet
It includes:
Each raw material is mixed, obtains described having effects that the composition of skin repair；
Preferably, each raw material is mixed under the conditions of 30~60 DEG C, obtains described having effects that the composition of skin repair.
5. a kind of drug for skin repair, which is characterized in that there is skin repair function including of any of claims 1 or 2
The composition of effect.
6. a kind of cosmetics for skin repair, which is characterized in that there is skin repair including of any of claims 1 or 2
The composition of effect.
7. cosmetics according to claim 6, which is characterized in that the cosmetics include in cream, lotion and essence
At least one.
8. cosmetics according to claim 7, which is characterized in that the cosmetics include cream, based on the cream
Gross mass, the content with the composition of skin repair are 4-10wt%.
9. cosmetics according to claim 7, which is characterized in that the cosmetics include lotion, based on the lotion
Gross mass, the content with the composition of skin repair are 3-7wt%.
10. cosmetics according to claim 7, which is characterized in that the cosmetics include essence, are based on the essence
The gross mass of element, the content with the composition of skin repair are 2-8wt%.
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Denomination of invention: Compositions with skin repair effects and their application in cosmetics Granted publication date: 20211102 Pledgee: Changzheng Medical Technology (Suzhou) Co.,Ltd. Pledgor: Changzheng Health Care (Yancheng) Co.,Ltd. Registration number: Y2024980016245 |