CN109091411A - A kind of infant's lotion and preparation method thereof - Google Patents
A kind of infant's lotion and preparation method thereof Download PDFInfo
- Publication number
- CN109091411A CN109091411A CN201811346159.3A CN201811346159A CN109091411A CN 109091411 A CN109091411 A CN 109091411A CN 201811346159 A CN201811346159 A CN 201811346159A CN 109091411 A CN109091411 A CN 109091411A
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- CN
- China
- Prior art keywords
- infant
- oil
- lotion
- ceramide
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006210 lotion Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 38
- 229940106189 ceramide Drugs 0.000 claims abstract description 38
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 38
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 38
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
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- 210000003423 ankle Anatomy 0.000 description 1
- 230000002804 anti-anaphylactic effect Effects 0.000 description 1
- 229940124623 antihistamine drug Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940046731 calcineurin inhibitors Drugs 0.000 description 1
- 125000001549 ceramide group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- STORWMDPIHOSMF-UHFFFAOYSA-N decanoic acid;octanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O STORWMDPIHOSMF-UHFFFAOYSA-N 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229940020485 elidel Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- KASDHRXLYQOAKZ-XDSKOBMDSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-XDSKOBMDSA-N 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical group CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960001967 tacrolimus Drugs 0.000 description 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000001745 uvea Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- Cosmetics (AREA)
Abstract
The present invention provides a kind of infant's lotions and preparation method thereof, belong to skin care field, the raw material including following weight percent: emulsifier 0.05%~5%, solid grease 0.1%~5%, liquid fat 5%~15%, moisturizer 5%~20%, rheology control agent 0.01%~2%, ceramide 0.01%~1%, other active components 0.1%~3%, the deionized water of preservative 0.1%~1% and surplus.Infant's lotion of the invention is compounded using ceramide with other active components for infant and the skin characteristic of infantile eczema, and being formed has the characteristics that tight security, nursing role and the infant skin care product for repairing trauma skin.The lotion skin sense exquisiteness is smooth, and moisturizing, antiallergic, tax rouge are had excellent performance, and can be improved the ability that infant's skin resists environmental stimuli and self-regeneration.In addition to this, infant's emulsion particle of the invention is uniform in size, has good stability.
Description
Technical field
The present invention relates to technical field of skin care more particularly to a kind of infant's lotion and preparation method thereof.
Background technique
The skin of infant have cuticula not yet develop completely, be easy to absorb foreign object, be easy that friction is impaired, adjusts soda acid
The features such as ability is poor, skin uvea is thin, regulating power is weak needs to develop suitable skin care item protection infant's skin.
Because easily suffering from skin eczema in infant period, for the skin characteristic of infant, not only need to consider the safety of skin care item
Property, to the good nursing of skin, it is also necessary to consider repair to damaged skin.
Infantile eczema, i.e. atopic dermatitis (atopic dermatitis, AD), also known as atopic dermatitis, dystopy
Property dermatitis, be a kind of chronic, recurrent, inflammatory dermatoses.It falls ill, and delays to children and adult more than infant period
Phase.With eczema sample fash, with violent itch, recurrent exerbation is clinical characters, often there is that apparent " spy answers in sufferer or family
Property ", seriously affect quality of life.It is seldom for the skin care item type of infantile eczema in the prior art and most of small to prevent
The skin care item of youngster's eczema lack with the infant skin care product for nursing and repairing trauma skin effect.
Summary of the invention
The purpose of the present invention is to provide a kind of infant's lotion and preparation method thereof, the lotion have tight security,
Nursing role and the good result for repairing trauma skin.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of infant's lotion, the raw material including following weight percent: emulsifier 0.05%~
5%, solid grease 0.1%~5%, liquid fat 5%~15%, moisturizer 5%~20%, rheology control agent 0.01%~
2%, ceramide 0.01%~1%, other active components 0.1%~3%, preservative 0.1%~1% and surplus go from
Sub- water；The other active components are α-bisabolol, Vitwas E, dipotassium glycyrrhizinate, allantoin, provitamin
One or more of B5, Honegsukle flower P.E and xylitol.
Preferably, the ceramide is one of III B of ceramide II, ceramide III and ceramide or several
Kind.
Preferably, the solid grease is shea butter, stearic acid, cetanol, one in the pure and mild docosyl alcohol of cetearyl alcohol
Kind is several；The liquid fat is macadimia nut oil, jojoba oil, avocado oil, saualane, white pond flower seed oil, olive oil, certain herbaceous plants with big flowers
Flower seed oil, grape seed oil, Sweet Almond Oil, wheat-germ oil, maize germ oil, camellia seed oil, peanut oil, hydrogenated rice bran oil, oil
In rapeseed oil, sesame seed oil, palm oil, palm-kernel oil, caprylic capric glyceryl ester, isomery hexadecane and dimethyl silicone polymer
One or more.
Preferably, the emulsifier is Phosphoric acid monohexadecyl ester potassium, polyglycereol-3-methyl distearate, arachidic alcohol &
Docosyl alcohol arachidic alcohol glucoside, the pure and mild cetearyl glucoside of cetearyl alcohol, C14-22 alcohol (and) C12-20 alkyl glucosides
One or more of glycosides and stearoyl-glutamic acid sodium.
Preferably, the moisturizer is one of glycerol, 1,3-BDO, polyethylene glycol and Sodium Hyaluronate or several
Kind.
Preferably, the rheology control agent is ammonium acryloyl taurate/VP copolymer, hydroxyethylacrylate &
One or more of sodium acryloyldimethyl taurate copolymers and xanthan gum.
Preferably, the preservative be glycerol caprylate, Sensiva SC50,1,2- pentanediol, 1,2- hexylene glycol, 1,
One or more of 2- ethohexadiol and Phenoxyethanol.
The present invention provides the preparation methods of infant's lotion described in above scheme, comprising the following steps:
1) ceramide and grease are mixed, obtains oil phase component；
2) moisturizer, rheology control agent, emulsifier, deionized water are mixed, obtains water phase components；
3) water phase components in the oil phase component and the step 2) in the step 1) are separately heated to 50~90 DEG C
Afterwards, the oil phase component after heating is added in the water phase components after heating, emulsifying, obtains mixing phase component；
4) other active components are added after the first stirring carries out cooling treatment in the mixing phase component in the step 3)
And preservative carries out cooling treatment through the second stirring, obtains infant's lotion.
Preferably, the revolving speed of emulsifying described in step 3) is 5000~19000rpm；The time of the emulsifying
For 1~5min.
Preferably, the revolving speed of the first stirring described in step 4) is 100~600r/min；First stirring is cooled down
The temperature of feed liquid is 45~55 DEG C after processing.
Advantageous effects of the invention: infant's lotion of the invention is special for the skin of infant and infantile eczema
Point is compounded using ceramide with other active components, and being formed has tight security, nursing role and reparation trauma skin special
The infant skin care product of point.Infant's lotion skin sense exquisiteness of the invention is smooth, and moisturizing, maintenance skin barrier, is alleviated Shu Min
Itch, tax rouge are had excellent performance, and have had both reparation and nursing effect, be can be improved infant's skin and are resisted environmental stimuli and allergy
Original infringement.Emollient is the safety and effective means for enhancing skin barrier function, exogenous lipid is provided for skin, to change
The characteristic of kind barrier.It protects newborn to fight the generation of scytitis, facilitates the generation for reducing anaphylactia.Except this it
Outside, infant's emulsion particle of the invention is uniform in size, has good stability.
Detailed description of the invention
Fig. 1 is the microscope photo of the obtained infant's product emulsion of embodiment 1 in the present invention.
Fig. 2 be the present invention in the obtained infant's product emulsion of embodiment 1 50 DEG C store 30 days after microscope photo.
Fig. 3 is the microscope photo after the obtained infant's product emulsion of the embodiment of the present invention 1 is stored 7 days at -18 DEG C.
Specific embodiment
The present invention provides a kind of infant's lotion, the raw material including following weight percent: emulsifier 0.05%~
5%, solid grease 0.1%~5%, liquid fat 5%~15%, moisturizer 5%~20%, rheology control agent 0.01%~2%,
Ceramide 0.01%~1%, other active components 0.1%~3%, the deionized water of preservative 0.1%~1% and surplus.
In the present invention, infant's lotion includes ceramide 0.01%~1%, preferably 0.02%~
0.5%, more preferably 0.1%~0.3%；The ceramide is in III B of ceramide II, ceramide III and ceramide
One or more, preferably III B of ceramide.
Ceramide II, ceramide III are common ceramide types in cosmetics, and ceramide is in cosmetics
It is middle application it is maximum limitation be the incompatible characteristic of its grease, be difficult to be added in system play the role of it is expected.And ceramide III
Than more than II hydroxyls of ceramide, III B of ceramide again more double bonds among hydrophobic group, these are all to promote its water
Dissolubility reduces its crystallization and is precipitated；Its moisture-keeping function is improved simultaneously.
Ceramide is a kind of lipid for being present in human skin, and important moisturizing, screen are played in horny layer of epidermis
The effects of barrier, antiallergic, moist, anti-oxidant, anti-aging.Due to the special role and effect of ceramide, it is being made up in recent years
Product formula in using increasingly extensive.Ceramide is to be bonded by a molecule sphingosinols and a molecular fat acids by amide
The compound of conjunction.Sphingosine moiety, the carbon chain lengths of fatty acid part, degree of unsaturation and hydroxy number therein are all that can become
Change and, so ceramide is a kind of compound rather than a kind of compound.
Since ceramide is mainly used for cosmetic industry, so its name mostly uses INCI (International
Nomenclature of cosmetic ingredients) naming method.The name of Ceramide is in INCI with document
It is classified as foundation, naturally occurring, erythro-structure ceramide is (even with day only in the lipid of animal skin cuticula
The identical sintetics of right product, as long as structure is identical), it just will use " Ceramide " word, altogether include 9 major class.But this 9
Major class is usually used in cosmetics being ceramide II, ceramide III, and ceramide III is divided into again: ceramide III, nerve
III A of amide, tri- kinds of III B of ceramide.
Chemically there are two hydrophobic groupings for tool in structure for ceramide, and contain the hydrophilic radical of 2~3 hydroxyls, cause
Make the characteristic that its water is insoluble, oil is insoluble, because it is easy to be precipitated, affects the application in skin-protection product system to a certain degree.Mind
Presence through amide 3 chiral sites, causes a variety of isomers of ceramide, the infiltration of different microstructures on the skin
Permeability and nursing property are also different.The wherein chemical structure of III B of ceramide are as follows:
In the present invention, the effect of ceramide is barrier action, adhesive effect, moisture-keeping function, anti-aging effects.
In the present invention, infant's lotion includes other active components 0.1%~3%, preferably 0.2%~2, more
Preferably 0.5%~1%；The other active components are α-bisabolol, vitamin E acetate, dipotassium glycyrrhizinate, allantois
One or more of element, provitamin B5, Honegsukle flower P.E and xylitol；Preferably allantoin, provitamin B5, dimension life
One or more of plain E acetate and bisabolol.
In the present invention, the effect of other active materials is moisturizing, antiallergy, promotes wound healing, nutrition.
In the present invention, the ceramide is compounded with allantoin, provitamin B5, bisabolol isoreactivity ingredient, tool
There are tight security, nursing role and repairs trauma skin effect.There is ceramide barrier action, adhesive effect, moisturizing to make
With, anti-aging effects；Allantoin has the function of promoting wound healing；Provitamin B5 has the function of moisture-keeping nutrient；It is red not have
Medicine alcohol has antianaphylactic effect.These raw materials compound together, synergistic can realize highly safe, nursing and repair wound
The effect of wound.
In the present invention, infant's lotion includes solid grease 0.1%~5%, preferably 0.2%~3%, more excellent
It is selected as 0.5%~1%；The solid grease is shea butter, stearic acid, cetanol, one in the pure and mild docosyl alcohol of cetearyl alcohol
Kind is several.
In the present invention, infant's lotion includes liquid fat 5%~15%, preferably 8%~12%, more preferably
It is 10%；The liquid fat is macadimia nut oil, jojoba oil, avocado oil, saualane, white pond flower seed oil, olive oil, sunflower
Seed oil, grape seed oil, Sweet Almond Oil, wheat-germ oil, maize germ oil, camellia seed oil, peanut oil, hydrogenated rice bran oil, rape
In seed oil, sesame seed oil, palm oil, palm-kernel oil, caprylic capric glyceryl ester, isomery hexadecane and dimethyl silicone polymer
It is one or more of.
In the present invention, the effect of the grease is to form closure film on the skin, has moisture-keeping function；Fat migration skin
In skin, play the role of assigning rouge.
In the present invention, the solid grease and liquid fat have tight security based on crude vegetal.
In the present invention, infant's lotion includes emulsifier 0.05%~5%, preferably 0.1%~3%, more excellent
It is selected as 1%~2%；The emulsifier is Phosphoric acid monohexadecyl ester potassium, polyglycereol-3-methyl distearate, the mountain arachidic alcohol &
Yu alcohol arachidic alcohol glucoside, the pure and mild cetearyl glucoside of cetearyl alcohol, C14-22 alcohol (and) C12-20 alkyl glucoside
One or more of with stearoyl-glutamic acid sodium.
In the present invention, infant's lotion includes moisturizer 5%~20%, preferably 8%~15%, more preferably
10%~12%；The moisturizer is one or more of glycerol, 1,3 butylene glycol, polyethylene glycol and Sodium Hyaluronate.
In the present invention, infant's lotion includes rheology control agent 0.01%~2%, preferably 0.05%~
1.5%, more preferably 0.1%~1%；The rheology control agent is ammonium acryloyl taurate/VP copolymer, ethoxy
One or more of acrylates & sodium acryloyldimethyl taurate copolymers and xanthan gum.
In the present invention, infant's lotion includes preservative 0.1%~1%, preferably 0.2%~0.5%, more excellent
It is selected as 0.3%~0.4%；The preservative be glycerol caprylate, Sensiva SC50,1,2- pentanediol, 1,2- hexylene glycol, 1,
One or more of 2- ethohexadiol and Phenoxyethanol.
In the present invention, infant's lotion further includes the deionized water of surplus.
The present invention provides the preparation methods of infant's lotion described in above scheme, comprising the following steps:
1) ceramide and grease are mixed, obtains oil phase component；
2) moisturizer, rheology control agent, emulsifier, deionized water are mixed, obtains water phase components；
3) water phase components in the oil phase component and the step 2) in the step 1) are separately heated to 50~90 DEG C
Afterwards, the oil phase component after heating is added in the water phase components after heating, emulsifying, obtains mixing phase component；
4) other active components are added after the first stirring carries out cooling treatment in the mixing phase component in the step 3)
And preservative carries out cooling treatment through the second stirring, obtains infant's lotion.
In the present invention, ceramide and grease are mixed, obtains oil phase component；The mixing temperature is preferably 50~90
DEG C, more preferably 70~80 DEG C；After temperature reaches assigned temperature, the incorporation time is preferably 10~30min, more preferably
15~20min.
In the present invention, moisturizer, rheology control agent, emulsifier, deionized water are uniformly mixed, obtain water phase components；Institute
Stating mixing temperature is preferably 50~90 DEG C, and more preferably 70~80 DEG C；After temperature reaches assigned temperature, the incorporation time is excellent
It is selected as 1~20min, more preferably 5~10min.
The present invention after obtaining oil phase component and water phase components, by oil phase component and water phase components be separately heated to 50~
90 DEG C, the oil phase component after heating is added in the water phase components after heating, emulsifying processing is carried out, obtains mixed phase group
Point；The revolving speed of the emulsifying be 5000~19000rpm, preferably 8000~15000rpm, more preferably 10000~
12000rpm；The time of the emulsifying is 1~5 min, preferably 2~4min, more preferably 3min.
In the present invention, the oil phase component after heating is added in the water phase components after heating using Natural Emulsification
Method prepares O/W system, directly formation O/W emulsion；If water phase is added in oily phase, belong to phase conversion emulsifying, in phase inversion
In the process, it is possible to be influenced by technique, expected O/W emulsion can not be formed.
By mixing phase component after the first stirring carries out cooling treatment, it is added after obtaining mixing phase component in the present invention
His active constituent and preservative carry out cooling treatment through the second stirring, obtain infant's lotion；The revolving speed of first stirring
For 100~600r/min, preferably 200~500r/min, more preferably 300~400r/min；First stirring carries out cold
But the temperature for handling feed liquid is 45~55 DEG C, preferably 50 DEG C；The revolving speed of second stirring is 100~600r/min, preferably
For 300~400r/min；The temperature that second stirring carries out feed liquid after cooling down is 16~26 DEG C, preferably 20 DEG C；The present invention
To stirring, the cooling time is not particularly limited.
A kind of infant's lotion provided by the invention and preparation method thereof is described in detail below with reference to embodiment,
But they cannot be interpreted as limiting the scope of the present invention.
Microscope used in the embodiment of the present invention is the GR-PL15 type petrographic microscope of GOLDROOM company.
A kind of infant's lotion of embodiment 1
Count by weight percentage, raw material composition and content are referring to table 1:
1 embodiment of table, 1 infant's emulsion formulations
The preparation method of above-mentioned infant's lotion, the specific steps are as follows:
(1) by A phase component (including arachidic alcohol docosyl alcohol arachidic alcohol glucoside, the pure and mild cetearyl Portugal of cetearyl alcohol
Glucosides, shea butter, cetostearyl alcohol, monoglyceride, macadimia nut oil, jojoba oil, avocado oil, saualane, olive oil, nerve
Amide IIIB, Vitwas E) it is heated to being completely dissolved to obtain oil phase component under the conditions of 70 DEG C；
(2) by B phase component (including glycerol, 1,3 butylene glycol, hyaluronic acid, allantoin, xanthan gum and acryloyl diformazan
Base taurine ammonium/VP copolymer) it is uniformly mixed to obtain water phase components；
(3) oil phase component and water phase components are heated to 90 DEG C respectively, oil phase component is added in water phase components
16000rpm emulsifying 3min；
(4) room temperature 500r/min stirring cooling, to system temperature be down to 50 DEG C of addition bisabolols, Honegsukle flower P.E with
And benzyl alcohol (and) benzoic acid (and) dehydroactic acid, infant's product emulsion can be obtained by continuing stirring to room temperature.
Infant's stability of emulsion of the present embodiment, skin sense exquisiteness spreadability are good, the lotion by microscopy, in the present embodiment
Product emulsified particle size is uniform, and the specific picture that detects is referring to Fig. 1.
A kind of infant's lotion of embodiment 2
Count by weight percentage, raw material composition and content such as table 2:
2 embodiment of table, 2 infant's emulsion formulations
The preparation method of above-mentioned infant's lotion, the specific steps are as follows:
(1) by A phase component (including cetostearyl alcohol, monoglyceride, macadimia nut oil, white pond flower seed oil, avocado oil, spiny dogfish
Alkane, olive oil, ceramide IIIB, Vitwas E) it is heated to being completely dissolved to obtain oil phase component under the conditions of 80 DEG C；
(2) by B phase component, (including Phosphoric acid monohexadecyl ester potassium, glycerol, 1,3 butylene glycol, hyaluronic acid, allantoin, the Chinese are raw
Glue and hydroxyethylacrylate & sodium acryloyldimethyl taurate copolymers) it is uniformly mixed to obtain water phase components；
(3) oil phase component and water phase components are heated to 85 DEG C respectively, oil phase component is added in water phase components
13500rpm emulsifying 3min；
(4) room temperature 400r/min stirring cooling, to system temperature be down to 50 DEG C of addition bisabolols, Honegsukle flower P.E,
1,2- hexylene glycol (and) pungent glycol (and) tropolone and pungent glycol (and) 1,2- hexylene glycol (and) methyl-benzyl alcohol,
Infant's product emulsion can be obtained by continuing stirring to room temperature.
Infant's lotion skin sense of the present embodiment is fine and smooth, observes particle after lotion is stored 1 month in 50 DEG C of insulating boxs
Size variation, microscopic examination result are shown in Fig. 2, and as the result is shown: particle size has almost no change, and illustrate that this stability of emulsion is good.
A kind of infant's lotion of embodiment 3
Count by weight percentage, raw material composition and content such as table 3:
3 embodiment of table, 3 infant's emulsion formulations
The preparation method of above-mentioned infant's lotion, the specific steps are as follows:
(1) by A phase component, (including polyglycereol-3-methyl distearate, cetostearyl alcohol, monoglyceride, Australia are hard
Fruit oil, Miglyol 812N, avocado oil, saualane, olive oil, ceramide IIIB, Vitwas E) at 60 DEG C
Under the conditions of be heated to being completely dissolved to obtain oil phase component；
(2) by B phase component (including glycerol, 1,3 butylene glycol, hyaluronic acid, allantoin, xanthan gum and hydroxylethyl
Hydrochlorate & sodium acryloyldimethyl taurate copolymers) it is uniformly mixed to obtain water phase components；
(3) oil phase component and water phase components are heated to 80 DEG C respectively, oil phase component is added in water phase components
13500rpm emulsifying 5min；
(4) room temperature 500r/min stirring cooling is down to 50 DEG C of addition dipotassium glycyrrhizinates to system temperature, honeysuckle is extracted
Object, Phenoxyethanol/Sensiva SC50, infant's product emulsion can be obtained by continuing stirring to room temperature.
The using effect for infant's lotion that 4 Examples 1 to 3 of embodiment obtains is verified
Using effect verification method:
Using Williams diagnostic criteria:
Main standard: skin sequence is come.
Minor criteria: 1. side skin involvement history, including when nest, friend's nest, (10 years old or less youngster is straight before ankle or around neck week
Including cheek)；2. asthma or allergic rhinitis history (or AD history occurs for grade relatives 4 years old or less children)；3. whole skin is dry
History；4. bending side has visible dermatitis；(5. morbidity (being suitable for being greater than 4 years old person) before 2 years old.It determines and diagnoses: main standard+3 or 3
The above minor criteria.
Subject meets claimed below:
(1) moderate atopic dermatitis (EASI scores 7.1-21.0 points)；IGA scores 2 points；
(2) age is at 2-12 years old (include 2 years old), male or female；
(3) tested to examine guardian and be ready during entire research by physician guidance to subject's use by test product；
(4) moisturizer is not used in subject before enrollment in 7 days: entering in group first 14 days and does not receive external medication, wraps
Include calcineurin inhibitors (external application tacrolimus or Elidel), Donisolone and external application Loratadine；
(5) subject does not receive non-steroid immunosuppressor (such as cyclosporine, methotrexate (MTX)) or purple in 4 weeks before enrollment
Outside line treatment；Non- system uses glucocorticoid preparation: non-system uses antihistamine drug:
(6) subject must not use other similar products during entire research；
According to the skin of subject, observation skin improves state after trying out, and as a result see the table below:
The using effect for infant's lotion that Examples 1 to 3 obtains
| Erythema | Infiltrate (oedema), papule | Abrasion | Mossization | |
| Embodiment 1 | It is obviously improved | It is obviously improved | It is obviously improved | It is obviously improved |
| Embodiment 2 | It is obviously improved | It is obviously improved | It is obviously improved | It is obviously improved |
| Embodiment 3 | It is obviously improved | It is obviously improved | It is obviously improved | It is obviously improved |
Product emulsion skin sense in the present embodiment is fine and smooth, and particle size variation in 1 month is stored in 50 DEG C of insulating boxs not
Greatly, it is precipitated without particulate matter within refrigerator freezing one week for -18 DEG C, microscopic examination result is shown in Fig. 3, illustrates that this stability of emulsion is good.
In conclusion a kind of infant's lotion of the invention, raw material sources used are reliable, have no toxic side effect, resulting
Product stability is good, and the ceramide contained and other active materials make the moisturizing of infant's skin, antiallergic and protection
With relatively good, preparation method is simple, reproducible.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of infant's lotion, the raw material including following weight percent: emulsifier 0.05%~5%, solid grease 0.1%
~5%, liquid fat 5%~15%, moisturizer 5%~20%, rheology control agent 0.01%~2%, ceramide 0.01%
~1%, the deionized water of other active components 0.1%~3%, preservative 0.1%~1% and surplus；
The other active components be α-bisabolol, Vitwas E, dipotassium glycyrrhizinate, allantoin, provitamin B5,
One or more of Honegsukle flower P.E and xylitol.
2. infant's lotion according to claim 1, which is characterized in that the ceramide is ceramide II, nerve
One or more of III B of amide III and ceramide.
3. infant's lotion according to claim 1, which is characterized in that the solid grease be shea butter, stearic acid,
One or more of pure and mild docosyl alcohol of cetanol, cetearyl alcohol；The liquid fat is macadimia nut oil, jojoba oil, crocodile
Pear oil, saualane, white pond flower seed oil, olive oil, sunflower oil, grape seed oil, Sweet Almond Oil, wheat-germ oil, maize germ
Oil, camellia seed oil, peanut oil, hydrogenated rice bran oil, rapeseed oil, sesame seed oil, palm oil, palm-kernel oil, caprylic capric three are sweet
One or more of grease, isomery hexadecane and dimethyl silicone polymer.
4. infant's lotion according to claim 1, which is characterized in that the emulsifier is Phosphoric acid monohexadecyl ester potassium, gathers
- 3 methyl distearate of glycerol, arachidic alcohol docosyl alcohol arachidic alcohol glucoside, the pure and mild cetearyl Portugal of cetearyl alcohol
Glucosides, C14-22 alcohol (and) one or more of C12-20 alkyl glucoside and stearoyl-glutamic acid sodium.
5. infant's lotion according to claim 1, which is characterized in that the moisturizer is glycerol, 1,3-BDO, gathers
One or more of ethylene glycol and Sodium Hyaluronate.
6. infant's lotion according to claim 1, which is characterized in that the rheology control agent is acryloyldimethyl ox
One of ichthyodin/VP copolymer, hydroxyethylacrylate & sodium acryloyldimethyl taurate copolymers and xanthan gum are several
Kind.
7. infant's lotion according to claim 1, which is characterized in that the preservative is glycerol caprylate, ethyl hexyl
Base glycerol, 1,2- pentanediol, 1,2- hexylene glycol, one or more of 1,2- ethohexadiol and Phenoxyethanol.
8. the preparation method of infant's lotion described in any one of claim 1~7, comprising the following steps:
1) ceramide and grease are mixed, obtains oil phase component；
2) moisturizer, rheology control agent, emulsifier, deionized water are mixed, obtains water phase components；
It 3), will after the water phase components in the oil phase component and the step 2) in the step 1) being separately heated to 50~90 DEG C
Oil phase component after heating is added in the water phase components after heating, emulsifying, obtains mixing phase component；
4) by the mixing phase component in the step 3) through first stirring carry out cooling treatment after, be added other active components and
Preservative carries out cooling treatment through the second stirring, obtains infant's lotion.
9. the preparation method of infant's lotion according to claim 8, which is characterized in that emulsifying described in step 3)
Revolving speed be 5000~19000rpm；The time of the emulsifying is 1~5min.
10. the preparation method of infant's lotion according to claim 8, which is characterized in that first stirs described in step 4)
The revolving speed mixed is 100~600r/min；The temperature of feed liquid is 45~55 DEG C after the first stirring progress cooling treatment.
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| CN109453100A (en) * | 2018-12-29 | 2019-03-12 | 拉芳家化股份有限公司 | A kind of full ingredient natural origin and the lotion without deionized water |
| CN109771328A (en) * | 2019-01-24 | 2019-05-21 | 广州雅纯化妆品制造有限公司 | A kind of mild children's skin toner composition and preparation method thereof |
| CN110269929A (en) * | 2019-08-13 | 2019-09-24 | 滨海昌正企业管理有限公司 | Have effects that the composition of skin repair and its application in cosmetics |
| CN110638694A (en) * | 2019-11-19 | 2020-01-03 | 庐山百草堂生物制药有限公司 | Skin-care oil composition for infants and preparation method thereof |
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| CN109771328A (en) * | 2019-01-24 | 2019-05-21 | 广州雅纯化妆品制造有限公司 | A kind of mild children's skin toner composition and preparation method thereof |
| CN111150680A (en) * | 2019-03-18 | 2020-05-15 | 上海臻臣化妆品有限公司 | A cosmetic composition comprising plant natural oil with excellent moisture keeping effect, and its preparation method |
| CN111150680B (en) * | 2019-03-18 | 2022-05-31 | 上海臻臣化妆品有限公司 | A method for preparing cosmetic composition comprising plant natural oil with excellent moisture keeping effect |
| CN110269929A (en) * | 2019-08-13 | 2019-09-24 | 滨海昌正企业管理有限公司 | Have effects that the composition of skin repair and its application in cosmetics |
| CN110269929B (en) * | 2019-08-13 | 2021-11-02 | 昌正医疗(苏州)有限公司 | Composition with skin repairing effect and application thereof in cosmetics |
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| WO2021136275A1 (en) * | 2019-12-31 | 2021-07-08 | 露乐健康科技(广州)股份有限公司 | Multi-stage fat-protecting skincare composition for protecting skin barrier of infants |
| CN112156058A (en) * | 2020-09-25 | 2021-01-01 | 深圳全棉时代科技有限公司 | Infant moisturizing lotion and preparation method thereof |
| CN114522120A (en) * | 2020-11-23 | 2022-05-24 | 守正创新生物科技(天津)有限公司 | Grease composition for balancing skin microecology and skin moistening emulsion thereof |
| CN114796067A (en) * | 2021-05-07 | 2022-07-29 | 杨庆瑞 | Multi-effect plant skin-care nano-emulsion product and application thereof |
| CN113350262A (en) * | 2021-06-30 | 2021-09-07 | 绽妍生物科技有限公司 | Skin cream suitable for atopic dermatitis of children |
| CN113350262B (en) * | 2021-06-30 | 2022-09-16 | 绽妍生物科技有限公司 | Skin cream suitable for atopic dermatitis of children |
| CN113908103A (en) * | 2021-11-15 | 2022-01-11 | 植物医生(广东)生物科技有限公司 | Mesona chinensis emulsion containing dendrobium officinale extract and preparation method thereof |
| WO2023230955A1 (en) * | 2022-06-01 | 2023-12-07 | Nivea (Shanghai) Co. Ltd. | Silicone-free emulsion i |
| CN116077357A (en) * | 2023-02-02 | 2023-05-09 | 福建省梦娇兰日用化学品有限公司 | Vitamin E-containing infant moisturizing emulsion and preparation method thereof |
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Application publication date: 20181228 |