CN113908103A - Mesona chinensis emulsion containing dendrobium officinale extract and preparation method thereof - Google Patents
Mesona chinensis emulsion containing dendrobium officinale extract and preparation method thereof Download PDFInfo
- Publication number
- CN113908103A CN113908103A CN202111349974.7A CN202111349974A CN113908103A CN 113908103 A CN113908103 A CN 113908103A CN 202111349974 A CN202111349974 A CN 202111349974A CN 113908103 A CN113908103 A CN 113908103A
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- CN
- China
- Prior art keywords
- extract
- emulsion
- dendrobium officinale
- thickening agent
- mixture
- Prior art date
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- Granted
Links
- 239000000284 extract Substances 0.000 title claims abstract description 85
- 239000000839 emulsion Substances 0.000 title claims abstract description 77
- 241001076416 Dendrobium tosaense Species 0.000 title claims abstract description 51
- 241001646828 Platostoma chinense Species 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract description 18
- 238000000605 extraction Methods 0.000 title description 5
- 239000002562 thickening agent Substances 0.000 claims abstract description 31
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 24
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 19
- 244000248416 Fagopyrum cymosum Species 0.000 claims abstract description 19
- 239000000419 plant extract Substances 0.000 claims abstract description 19
- 241001646834 Mesona Species 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 8
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 19
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 14
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- 239000003906 humectant Substances 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 13
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- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 6
- 229940044176 ceramide 3 Drugs 0.000 claims description 6
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims description 5
- 125000003368 amide group Chemical group 0.000 claims description 5
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- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 4
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 4
- 229940106189 ceramide Drugs 0.000 claims description 4
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 4
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 4
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a mesona chinensis benth emulsion containing a dendrobium officinale extract and a preparation method thereof, belonging to the technical field of cosmetics. The mesona blume emulsion disclosed by the invention contains the plant extract, the plant extract takes the dendrobium officinale extract as a core raw material, and is mixed with the honeysuckle extract and the wild buckwheat extract, so that the corrosion prevention effect of the product is obviously improved, the product still has a good antibacterial effect on the basis of no preservative, the specific components and the mass ratio of the thickening agent and the emulsifying agent are controlled in the implementation process, the stability of the product can be obviously improved through the matching of the thickening agent and the emulsifying agent, and the long-term high-low temperature stability is realized.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a mesona chinensis benth emulsion containing a dendrobium officinale extract and a preparation method thereof.
Background
Dendrobium officinale (Dendrobium officinale Kimura et Migo) is the stem of Dendrobium officinale belonging to the genus Dendrobium of the family Orchidaceae, also known as Equisetum nigrum. It is recorded in Shen nong Ben Cao Jing (Shen nong's herbal), and famous for its special living environment and excellent nourishing effect, named as "Zhonghua Jiu Da Xian Cao". The dendrobium officinale contains nutrient components such as dendrobium polysaccharide, alkaloid, amino acid, colloid and the like, has super-strong water locking capacity, and can effectively resist the generation of fine wrinkles, improve the generated fine wrinkles and moisten the skin. Research shows that the dendrobium officinale polysaccharide component is beneficial to improving the drug effect of the dendrobium officinale, such as improving the immunity of organisms, resisting tumors, aging, fatigue and blood sugar, and the like. Polysaccharides are important bioactive macromolecules, are four compounds which are combined with nucleic acid, protein and fat and are called life activities, and are important components of the dermis of human skin. The polysaccharide has an outstanding regulating effect in the skin metabolism process, provides a basis for the application of the polysaccharide in cosmetics due to the biological activity and the physicochemical property of the polysaccharide, has no toxic or side effect, and has good compatibility with common cosmetic components.
Therefore, many records exist on the dendrobium officinale extract as an active ingredient of cosmetics, and for example, a moisturizing composition, a preparation method and application thereof are disclosed in Chinese patent application 201510505365.4. The moisturizing composition mainly comprises 10-25 parts of plant extract liposome, 3-10 parts of dendrobium officinale extract, 3-10 parts of aloe extract, 0-3 parts of natural moisturizing factor and 0-3 parts of ceramide, and the obtained moisturizing composition can reach the dermis, repair stroma cells of the dermis, promote the synthesis of collagen, elastin and mucopolysaccharide and improve the composition and structure of the stroma of the dermis, so that the effects of deeply moisturizing and repairing the dermis are achieved, and the problem of dry skin is fundamentally solved.
For another example, chinese patent application 201910141631.8 discloses a dendrobium officinale mask and a preparation method thereof, comprising a main material and an auxiliary material, wherein the main material comprises an extract and a conditioner, and the extract comprises a chamomile extract, a arnica extract, a dendrobium officinale extract, an aloe extract, maltodextrin and hydrolyzed oat protein. According to the invention, different extracts are added as main materials for preparing the mask, the golden chamomile extract has the effects of helping sleep and moistening skin, the arnica extract can be mixed with other extracts for use to promote skin health, the dendrobium officinale extract and the aloe extract can effectively prevent cell aging, enable skin to be astringent, soft, moisturized and anti-inflammatory, and have the effects of removing sclerosis and keratinization and improving scars, so that small wrinkles and skin looseness can be prevented, and skin can be kept moist and tender.
The applicant of the invention prepares various cosmetics by taking the dendrobium officinale extract as a core raw material for the dendrobium officinale extract for a long time, for example, Chinese patent application 201711350219.4 discloses a mesona chinensis benth emulsion containing the dendrobium officinale extract, which comprises a component A, a component B, a component C, a component D, a component E and a component F, the application adopts dendrobium officinale to fuse alpine plant extract combined components with excellent age-defending effect, and is matched with shaddock ceramide with the function of relieving and anti-allergy and bioactive polypeptide with the function of resisting wrinkle, so that fine lines and skin can be repaired and tightened while lasting moisture retention, relieving and anti-allergy are realized, and thus, the skin care mesona chinensis benth emulsion with the effects of resisting aging and resisting allergy is provided for people.
However, the components of the application are added with a certain amount of preservative, and related researches show that excessive or improper chemical preservative can lead epidermal cells to develop immature and loose structure, so that the epidermal layer becomes thin, is easy to be stimulated by the outside and has reduced defense capacity; even can damage cell DNA, so that the skin gradually loses elasticity and is easy to generate relaxation and fine lines; skin cells damaged by the preservative are continuously defectively propagated, the skin is poorer and poorer, and the use experience of the lotion is obviously influenced, so that the sianchau lotion which takes the dendrobium officinale extract as a core raw material and does not contain the preservative and the preparation method thereof need to be developed, and the applicant improves the formula through years of research to obtain the technical scheme protected by the invention.
Disclosure of Invention
Based on the problems in the prior art, the invention aims to provide the mesona blume emulsion containing the dendrobium officinale extract and the preparation method thereof.
The invention is realized by the following technical scheme.
A Mesona chinensis emulsion containing Dendrobium officinale extract comprises plant extract, wherein the plant extract is a mixture of Dendrobium officinale extract, honeysuckle extract and wild buckwheat rhizome extract;
the mass ratio of the dendrobium officinale extract to the honeysuckle extract to the wild buckwheat rhizome extract is 3-10:1: 1;
preferably, the mass ratio of the dendrobium officinale extract to the honeysuckle extract to the wild buckwheat rhizome extract is 3.5-5:1: 1;
preferably, the mass ratio of the dendrobium officinale extract to the honeysuckle extract to the wild buckwheat rhizome extract is 4:1: 1.
Wherein, the dendrobium officinale extract is 5-10 parts, the honeysuckle extract is 0.5-2 parts and the wild buckwheat extract is 0.5-2 parts by weight.
Preferably, the dendrobium officinale extract is 6-8 parts, the honeysuckle extract is 1-2 parts and the wild buckwheat rhizome extract is 1-2 parts by weight.
Further preferably, the dendrobium officinale extract is 8 parts, the honeysuckle extract is 2 parts and the wild buckwheat rhizome extract is 2 parts by weight.
The mesona blume emulsion also comprises 0.1 to 0.5 part of thickening agent, preferably 0.2 to 0.4 part;
the thickening agent is selected from one or more of coconut oil amino hydroxy sulfobetaine, spermaceti hydroxyethyl cellulose, alkyl dimethyl ammonium oxide, hydroxyethyl cellulose, xanthan gum, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and acrylic acid (ester)/acrylamide copolymer;
preferably, the thickening agent is selected from one or more of coco amido hydroxy sulfobetaine, spermaceti hydroxyethyl cellulose, alkyl dimethyl ammonium oxide, hydroxyethyl cellulose and xanthan gum;
preferably, the thickening agent is a mixture of coco amido hydroxy sulfobetaine, cetyl hydroxyethyl cellulose and alkyl dimethyl ammonium oxide, and the mass ratio of the coco amido hydroxy sulfobetaine to the cetyl hydroxyethyl cellulose to the alkyl dimethyl ammonium oxide is 2-3:1: 1.
As known to those skilled in the art, the emulsion needs a certain viscosity relative to the lotion, but the lotion has poor moisturizing effect after being used, especially the effect of users with dry skin is poor, but the emulsion is not easy to coat due to too high viscosity, and the thick feeling is strong.
The mesona blume emulsion also comprises 5-15 parts of humectant; preferably 8 to 12 parts.
The humectant is selected from one or more of glycerol, sorbitol, polyethylene glycol, 1, 3-butanediol and propylene glycol;
preferably glycerol.
The mesona blume emulsion also comprises 0.5 to 2.5 parts of emulsifier, preferably 1 to 2 parts;
the emulsifier is one or more selected from cetearyl alcohol, cetearyl glucoside, glyceryl stearate, cetearyl olive oleate and sorbitan olive oleate.
Preferably, the emulsifier is a mixture of cetearyl alcohol, cetearyl glucoside and cetearyl olivate;
still preferably, the mass ratio of cetearyl alcohol, cetearyl glucoside and cetearyl olive oleate is 1-2:1: 1.
In the implementation process, the invention unexpectedly discovers that the components in the emulsion can be better mixed by mixing the cetearyl alcohol, the cetearyl glucoside and the cetearyl olive oleate serving as the emulsifying agent, so that the compatibility among the components is improved, the emulsifying effect can be obviously improved by controlling the ratio of the cetearyl alcohol, the cetearyl glucoside and the cetearyl olive oleate to be 1-2:1:1 for compounding, and all the components can be fully emulsified without layering.
As some preferred technical schemes, the mesona blume emulsion also comprises 0.1 to 0.5 portion of hydrogenated lecithin, 0.2 to 0.4 portion of hyaluronic acid, 1 to 5 portions of caprylic/capric triglyceride, 30.2 to 0.8 portion of ceramide, 0.1 to 0.5 portion of arginine and 0.1 to 0.5 portion of citric acid.
In some preferred embodiments, the mass ratio of the thickener to the emulsifier is 1:4 to 10; preferably 1: 6-8; still more preferably 1: 6.
The mesona blume emulsion also comprises 60-80 parts of deionized water.
The invention also provides a preparation method of the mesona chinensis benth emulsion, which comprises the following steps:
(1) adding a thickening agent, a humectant, hydrogenated lecithin, hyaluronic acid and deionized water into a water phase pot, stirring and heating to 80-85 ℃ to completely dissolve the thickening agent, the humectant, the hydrogenated lecithin, the hyaluronic acid and the deionized water to obtain a water phase material;
(2) adding emulsifier and caprylic/capric triglyceride into oil phase pot, stirring and heating to 80-85 deg.C, and dissolving completely to obtain oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 1-5min, and keeping the temperature at 80-85 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding arginine and citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract and the ceramide-3, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
Compared with the prior art, the invention has the beneficial effects that:
(1) the mesona blume lotion disclosed by the invention contains plant extracts, the plant extracts take the dendrobium officinale extracts as core raw materials, the dendrobium officinale extracts are mixed with the honeysuckle extracts and the wild buckwheat extracts, the corrosion prevention effect of the product is obviously improved, the product still has a good antibacterial effect on the basis of not adding preservatives, and the mass ratio of the dendrobium officinale extracts to the honeysuckle extracts to the wild buckwheat extracts is 3-10:2: 2.
(2) According to the invention, the mixture of cocoamidohydroxysulfobetaine, cetyl hydroxyethylcellulose and alkyl dimethyl ammonium oxide in a mass ratio of 2-3:1:1 is used as a thickening agent, so that the viscosity of the emulsion is moderate, and the user experience is high;
(3) in the implementation process, the invention unexpectedly discovers that the components in the emulsion can be better mixed by mixing the cetearyl alcohol, the cetearyl glucoside and the cetearyl olive oleate serving as the emulsifier, so that the compatibility among the components is improved, the emulsifying effect can be obviously improved by controlling the proportion of the cetearyl alcohol, the cetearyl glucoside and the cetearyl olive oleate to be 1-2:1:1 for compounding, all the components can be fully emulsified, the emulsifying effect is obviously improved, the components cannot be layered in the preparation process, and the durability of the product is improved;
(4) the mass ratio of the thickening agent to the emulsifier is controlled to be 1:4-10 in the implementation process, and the stability of the product can be obviously improved through the matching of the thickening agent and the emulsifier, so that the product has long-term high and low temperature stability.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
In addition, the dendrobium officinale extract is purchased from Shanxi New Tian territory Biotechnology Co., Ltd, the honeysuckle extract and the wild buckwheat extract are purchased from Nanjing Zealand Biotechnology Co., Ltd, and other raw materials are all common commercial products, so the source of the dendrobium officinale extract is not particularly limited.
Examples 1-3A Mesona emulsion containing Dendrobium officinale extract and its preparation method
The paint comprises the following components in parts by weight:
the preparation method of the mesona chinensis benth emulsion comprises the following steps:
(1) adding the thickening agent, the humectant and deionized water into a water phase pot, stirring and heating to 80 ℃ to completely dissolve the thickening agent, the humectant and the deionized water to obtain a water phase material;
(2) adding the emulsifier into an oil phase pot, stirring and heating to 85 ℃, and completely dissolving to obtain an oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 5min, and keeping the temperature at 80 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
Example 4 Mesona emulsion containing dendrobium officinale extract and preparation method thereof
The paint comprises the following components in parts by weight:
the preparation method of the mesona chinensis benth emulsion comprises the following steps:
(1) adding a thickening agent, a humectant, hydrogenated lecithin, hyaluronic acid and deionized water into a water phase pot, stirring and heating to 85 ℃ to completely dissolve the thickening agent, the humectant, the hydrogenated lecithin, the hyaluronic acid and the deionized water to obtain a water phase material;
(2) then adding the emulsifier and caprylic/capric triglyceride into an oil phase pot, stirring and heating to 85 ℃, and completely dissolving to obtain an oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 4min, and keeping the temperature at 85 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding arginine and citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract and the ceramide-3, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
Example 5 Mesona emulsion containing Dendrobium officinale extract and preparation method thereof
The paint comprises the following components in parts by weight:
the preparation method of the mesona chinensis benth emulsion comprises the following steps:
(1) adding a thickening agent, a humectant, hydrogenated lecithin, hyaluronic acid and deionized water into a water phase pot, stirring and heating to 85 ℃ to completely dissolve the thickening agent, the humectant, the hydrogenated lecithin, the hyaluronic acid and the deionized water to obtain a water phase material;
(2) then adding the emulsifier and caprylic/capric triglyceride into an oil phase pot, stirring and heating to 85 ℃, and completely dissolving to obtain an oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 4min, and keeping the temperature at 85 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding arginine and citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract and the ceramide-3, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
Example 6 Mesona emulsion containing Dendrobium officinale extract and preparation method thereof
The paint comprises the following components in parts by weight:
the preparation method of the mesona chinensis benth emulsion comprises the following steps:
(1) adding a thickening agent, a humectant, hydrogenated lecithin, hyaluronic acid and deionized water into a water phase pot, stirring and heating to 85 ℃ to completely dissolve the thickening agent, the humectant, the hydrogenated lecithin, the hyaluronic acid and the deionized water to obtain a water phase material;
(2) then adding the emulsifier and caprylic/capric triglyceride into an oil phase pot, stirring and heating to 85 ℃, and completely dissolving to obtain an oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 4min, and keeping the temperature at 85 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding arginine and citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract and the ceramide-3, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
Comparative example 1
The difference from example 6 is that: the plant extract only contains dendrobium officinale extract and honeysuckle extract, namely 9.6 parts of dendrobium officinale extract and 2.4 parts of honeysuckle extract, and other operations and steps are the same as those in example 6.
Comparative example 2
The difference from example 6 is that: the plant extracts only contain dendrobium officinale extract and wild buckwheat rhizome extract, namely 9.6 parts of dendrobium officinale extract and 2.4 parts of wild buckwheat rhizome extract, and other operations and steps are the same as those in example 6.
Comparative example 3
The difference from example 6 is that: the mass ratio of the thickening agent to the emulsifier is 1:3, namely
The other operations and steps are the same as in example 6.
Comparative example 4
The difference from example 6 is that: the mass ratio of the thickening agent to the emulsifier is 1:13, namely
The other operations and steps are the same as in example 6.
Comparative example 5
Mesona chinensis emulsion disclosed in Chinese patent application 201711350219.4.
Effect test
1. Testing of antibacterial Properties of emulsions
The detection strains of Escherichia coli 8099, Staphylococcus aureus ATCC6538 and Candida albicans ATCC10231 are all commercial strains.
Firstly, bacterial liquid culture is carried out: respectively inoculating Escherichia coli and Staphylococcus aureus to broth culture solution, culturing at 37 deg.C for 24h, inoculating Candida albicans to sandwich weak liquid culture medium, and culturing at 25 deg.C for 5d to obtain a certain amount of bacterial suspension.
The detection method comprises the following steps: to 10g of each of the emulsions prepared in examples 4 to 6 of the present invention and comparative examples 1 to 2 and 5 was added 0.2mL of 106And (3) repeatedly and uniformly stirring three bacterial liquids of CFU/mL, respectively measuring at 3d, 7d and 14d, and counting bacteria by using lecithin/Tween 80-nutrient agar. The results are shown in Table 1 below and are expressed as percentage (%) reduction of the species.
TABLE 1 tests for bacteriostatic Properties of emulsions prepared in examples 4-6 and comparative examples 1-2, 5
According to the detection data in the table 1, the emulsion prepared by the invention takes the dendrobium officinale extract as the core raw material, and the dendrobium officinale extract is mixed with the honeysuckle extract and the wild buckwheat extract, so that the antiseptic effect of the product is obviously improved, the product still has a good antibacterial effect on the basis of not adding preservatives, the mass ratio of the dendrobium officinale extract, the honeysuckle extract and the wild buckwheat extract in the examples 5-6 is in the range claimed by the invention, the antibacterial effect of the obtained emulsion is superior to that of the emulsion prepared in the example 1, especially the mass ratio of the dendrobium officinale extract, the honeysuckle extract and the wild buckwheat extract in the example 6 is 4:1:1, the obtained emulsion has the best antibacterial effect, the types of the plant extracts are changed in the comparative examples 1-2, and the antibacterial effect of the emulsion is obviously reduced compared with that of the example 6, the emulsion of comparative example 5 has a bacteriostatic effect comparable to that of examples 5 to 6 because of the presence of a preservative, but the emulsion of comparative example 5 is less safe.
2. Emulsion stability test
The test method comprises the following steps: the emulsions of examples 4 to 6 and comparative examples 3 to 4 were stored at 40 ℃ for 24 hours, at room temperature for 24 hours, and at-5 ℃ for 24 hours, and then circulated for 3 times, and the presence of delamination, oil slick, and color change was observed, and the results are shown in Table 2 below.
TABLE 2
| Group of | Whether or not to stratify | Whether or not to float oil | Whether there is a change in color or not |
| Example 4 | Whether or not | Whether or not | Whether or not |
| Example 5 | Whether or not | Whether or not | Whether or not |
| Example 6 | Whether or not | Whether or not | Whether or not |
| Comparative example 3 | Whether or not | Is provided with | Is provided with |
| Comparative example 4 | Is provided with | Is provided with | Is provided with |
According to the test results in table 2 above, the emulsions prepared in examples 4-5 of the present invention have good stability, and no delamination, oil floating and discoloration occur after the cooling and heating cycles, while in comparative examples 3-4, the interaction between the thickener and the emulsifier is weakened by changing the mass ratio of the thickener and the emulsifier out of the protection range of the present invention, thereby significantly affecting the stability of the product, and delamination or discoloration occurs after the cooling and heating cycles.
3. Detection of moisturizing and skin-tendering and oil-controlling effects
(1) Experimental population
70 female volunteers of 20-50 years old are selected, and are randomly and averagely divided into 7 groups of 10.
(2) Laboratory apparatus
Skin moisture tester (Cormeter CM 825; Germany CK): the water content of the stratum corneum of human skin is measured by a capacitance method.
Skin oil tester (Sebumeter): based on the principle of a photometer, after absorbing grease on human skin, a special extinction adhesive tape with the thickness of 0.1mm can be changed into a semitransparent adhesive tape, the light transmittance of the semitransparent adhesive tape can be changed, the more grease is absorbed, the greater the light transmittance is, otherwise, the smaller the light transmittance is, and therefore, the content of the grease on the skin can be measured.
(3) Experimental methods
After cleaning the face, the lotion is smeared on the face until being absorbed, and cleaning is not needed; used 3 times per week for 4 weeks; before testing, the test subjects cleaned their faces with clear water, wiped clean with facial tissue, and started to measure after sitting still in a constant temperature and humidity laboratory (temperature 20. + -. 1 ℃ C., humidity 55. + -. 3) for 30 minutes. A4 x 4cm area in the middle of the right face of each human subject is selected, and the average capacitance values of the four corners and the middle of the area are tested by a probe for 5 positions in total. Then testing the average capacitance value and the grease amount of each group of people respectively according to the methods after trial of 0W, 2W, 4W and 6W of the emulsion.
(4) Evaluation method
Skin moisture content MMV value: the MMV value is indicative of skin moisture, the larger the MMV value is, the higher the stratum corneum moisture content is;
the smaller the grease quantity value is, the less the oil output is shown, and the better the oil control effect is
The results of the experiments are shown in tables 3-4 below.
TABLE 3 comparison of moisturizing Effect of the products of examples 1-6 and comparative example 5
TABLE 4 results comparing oil control Effect of the products of examples 1-6 and comparative example 5
As can be seen from the test data in Table 3 above, the emulsions prepared in examples 1 to 6 of the present invention and comparative example 5 each had a moisturizing effect. However, the water replenishing effect of the emulsion is obviously influenced by the fact that no hydrogenated lecithin, hyaluronic acid, caprylic/capric triglyceride, ceramide-3 and arginine are added in the example 1-2, the water replenishing effect of the emulsion prepared in the example 3-6 is obviously better than that of the emulsion prepared in the example 1-2, particularly, the water replenishing effect of the emulsion prepared in the example 6 is the best under the conditions that the adding content and the proportion of each component are excellent, and the water replenishing effect of the emulsion prepared in the comparative example 5 is also worse than that of the emulsion prepared in the example 6 and the safety is low, so that the skin moisturizing effect of the emulsion prepared in the example 3-6 can be improved.
According to the detection results in the table 4, the oil control effect of the emulsions prepared in the examples 3 to 6 is obviously better than that of the emulsions prepared in the examples 1 to 2, especially the oil control effect of the emulsion prepared in the example 6 is the best under the condition that the addition content and the proportion of each component are better, and the oil control effect of the emulsion prepared in the comparative example 5 is also worse than that of the emulsion prepared in the example 6 and the safety is low, so that the emulsions prepared in the examples 3 to 6 have better oil control effect.
The above detailed description is specific to possible embodiments of the present invention, and the embodiments are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the scope of the present invention should be included within the technical scope of the present invention.
Claims (10)
1. A mesona chinensis benth emulsion containing dendrobium officinale extract is characterized in that: the Mesona chinensis emulsion comprises plant extracts; the plant extract is a mixture of dendrobium officinale extract, honeysuckle extract and wild buckwheat rhizome extract;
the mass ratio of the dendrobium officinale extract to the honeysuckle extract to the wild buckwheat rhizome extract is 3-10:1: 1.
2. The immortal grass emulsion according to claim 1, characterized in that: 5-10 parts of dendrobium officinale extract, 0.5-2 parts of honeysuckle extract and 0.5-2 parts of wild buckwheat rhizome extract.
3. The immortal grass emulsion according to claim 1, characterized in that: the mesona blume emulsion also comprises 0.1 to 0.5 portion of thickening agent;
the thickening agent is selected from one or more of coconut oil amino hydroxy sulfobetaine, spermaceti hydroxyethyl cellulose, alkyl dimethyl ammonium oxide, hydroxyethyl cellulose, xanthan gum, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and acrylic acid (ester)/acrylamide copolymer.
4. The immortal grass emulsion according to claim 3, characterized in that: the thickening agent is a mixture of coco amido hydroxy sulfobetaine, cetyl hydroxyethyl cellulose and alkyl dimethyl ammonium oxide, and the mass ratio of the coco amido hydroxy sulfobetaine to the cetyl hydroxyethyl cellulose to the alkyl dimethyl ammonium oxide is 2-3:1: 1.
5. The immortal grass emulsion according to claim 1, characterized in that: the mesona blume emulsion also comprises 0.5 to 2.5 parts of emulsifier;
the emulsifier is one or more selected from cetearyl alcohol, cetearyl glucoside, glyceryl stearate, cetearyl olive oleate and sorbitan olive oleate.
6. The immortal grass emulsion according to claim 5, wherein: the mass ratio of the cetearyl alcohol, the cetearyl glucoside and the cetearyl olive oleate is 1-2:1: 1.
7. The immortal grass emulsion according to claim 1, characterized in that: the mesona blume emulsion also comprises 0.1 to 0.5 portion of hydrogenated lecithin, 0.2 to 0.4 portion of hyaluronic acid, 1 to 5 portions of caprylic/capric triglyceride, 30.2 to 0.8 portion of ceramide, 0.1 to 0.5 portion of arginine and 0.1 to 0.5 portion of citric acid.
8. The immortal grass emulsion according to claim 3 or 5, characterized in that: the mass ratio of the thickening agent to the emulsifier is 1: 4-10.
9. The immortal grass emulsion according to claim 8, wherein: the mass ratio of the thickening agent to the emulsifier is 1: 6.
10. A method for preparing mesona chinensis benth emulsion as claimed in any one of claims 1 to 9, wherein: the method comprises the following steps:
(1) adding a thickening agent, a humectant, hydrogenated lecithin, hyaluronic acid and deionized water into a water phase pot, stirring and heating to 80-85 ℃ to completely dissolve the thickening agent, the humectant, the hydrogenated lecithin, the hyaluronic acid and the deionized water to obtain a water phase material;
(2) adding emulsifier and caprylic/capric triglyceride into oil phase pot, stirring and heating to 80-85 deg.C, and dissolving completely to obtain oil phase material;
(3) sequentially sucking the water phase material prepared in the step (1) and the oil phase material prepared in the step (2) into an emulsifying kettle, homogenizing for 1-5min, and keeping the temperature at 80-85 ℃ to obtain a mixture A;
(4) when the temperature of the mixture A is reduced to 60 ℃, adding arginine and citric acid to adjust the pH value of the material to 6-6.5 to obtain a mixture B;
(5) and when the temperature of the mixture B is continuously reduced to 50 ℃, adding the plant extract and the ceramide-3, uniformly stirring, and continuously reducing the temperature to 40 ℃ to obtain the mesona chinensis benth emulsion.
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Citations (4)
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|---|---|---|---|---|
| CN105125467A (en) * | 2015-09-30 | 2015-12-09 | 青岛海之源智能技术有限公司 | Emulsion removing red blood and preparing method of emulsion |
| CN107184499A (en) * | 2017-04-12 | 2017-09-22 | 广州环亚化妆品科技有限公司 | A kind of long-acting moisturizing emulsion mask composition of natural botanical source and preparation method thereof |
| CN107982171A (en) * | 2017-12-15 | 2018-05-04 | 广东盛美化妆品有限公司 | A kind of celestial grass lotion of the Herba Dendrobii extract containing iron sheet and preparation method thereof |
| CN109091411A (en) * | 2018-11-13 | 2018-12-28 | 王亚平 | A kind of infant's lotion and preparation method thereof |
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2021
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125467A (en) * | 2015-09-30 | 2015-12-09 | 青岛海之源智能技术有限公司 | Emulsion removing red blood and preparing method of emulsion |
| CN107184499A (en) * | 2017-04-12 | 2017-09-22 | 广州环亚化妆品科技有限公司 | A kind of long-acting moisturizing emulsion mask composition of natural botanical source and preparation method thereof |
| CN107982171A (en) * | 2017-12-15 | 2018-05-04 | 广东盛美化妆品有限公司 | A kind of celestial grass lotion of the Herba Dendrobii extract containing iron sheet and preparation method thereof |
| CN109091411A (en) * | 2018-11-13 | 2018-12-28 | 王亚平 | A kind of infant's lotion and preparation method thereof |
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