CN111228138A - Hyaluronic acid essence and preparation method thereof - Google Patents
Hyaluronic acid essence and preparation method thereof Download PDFInfo
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- CN111228138A CN111228138A CN202010159721.2A CN202010159721A CN111228138A CN 111228138 A CN111228138 A CN 111228138A CN 202010159721 A CN202010159721 A CN 202010159721A CN 111228138 A CN111228138 A CN 111228138A
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- Prior art keywords
- skin
- moisturizing
- glycerol
- conditioning agent
- skin conditioning
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 35
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 35
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 140
- 230000003750 conditioning effect Effects 0.000 claims abstract description 110
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 91
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 62
- 239000000203 mixture Substances 0.000 claims abstract description 54
- 239000002994 raw material Substances 0.000 claims abstract description 38
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 24
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 24
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 24
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims abstract description 18
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003906 humectant Substances 0.000 claims abstract description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 14
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000011734 sodium Substances 0.000 claims abstract description 14
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims description 46
- 238000003756 stirring Methods 0.000 claims description 28
- 239000002562 thickening agent Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 12
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 9
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- -1 ceramide 2 Chemical compound 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 7
- 238000000855 fermentation Methods 0.000 claims description 7
- 230000004151 fermentation Effects 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 229940099417 ceramide 2 Drugs 0.000 claims description 4
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 229940107161 cholesterol Drugs 0.000 claims description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 229940105132 myristate Drugs 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 4
- 235000010384 tocopherol Nutrition 0.000 claims description 4
- 229960001295 tocopherol Drugs 0.000 claims description 4
- 229930003799 tocopherol Natural products 0.000 claims description 4
- 239000011732 tocopherol Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 3
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000008269 hand cream Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 239000006166 lysate Substances 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims description 2
- 230000001333 moisturizer Effects 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 6
- 229920001577 copolymer Polymers 0.000 description 4
- 239000004148 curcumin Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 3
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 3
- 238000011914 asymmetric synthesis Methods 0.000 description 3
- 229940106189 ceramide Drugs 0.000 description 3
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical group CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 3
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229940104261 taurate Drugs 0.000 description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 2
- 238000012009 microbiological test Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000006053 organic reaction Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 230000000707 stereoselective effect Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- PNNNRSAQSRJVSB-KCDKBNATSA-N aldehydo-L-fucose Chemical compound C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-KCDKBNATSA-N 0.000 description 1
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical group [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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Abstract
The invention relates to the field of preparation of cosmetics, and provides a moisturizing and moisturizing conditioning composition, which at least comprises the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: (1-2); the humectant at least comprises one of glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium; the skin conditioning agent comprises at least one of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, and a fourth skin conditioning agent; the weight ratio of the first skin conditioning agent, the second skin conditioning agent, the third skin conditioning agent and the fourth skin conditioning agent is (5-15): (0.5-1.5): (0.5-1.5): 1. and provides hyaluronic acid essence.
Description
Technical Field
The invention relates to the field of preparation of cosmetics, and particularly relates to hyaluronic acid essence and a preparation method thereof, a moisturizing and conditioning composition and application thereof.
Background
Hyaluronic acid, also known as hyaluronic acid, is one of the components of human dermal tissue, widely exists in intercellular substance, can normally exist in the body, and can be completely absorbed by the body. In addition, hyaluronic acid is also a skin moisturizing factor, has the function of absorbing 500-1000 times of water, has excellent moisturizing effect, and is called as an ideal natural moisturizing factor. Hyaluronic acid is used in cosmetics, has unique skin protecting effect, can keep skin moist, smooth, fine, tender and elastic, and has effects of preventing wrinkle, removing wrinkle, caring skin, promoting health and recovering skin physiological function. Many medical personnel or chemical researchers exist, and all people are exposed to some chemical substances for a long time, but the long-term exposure can cause large pores and rough and dull skin. However, the existing hyaluronic acid cosmetics do not have the effect of making pores fine, but people often have large pores due to dry skin, so that a lot of troubles are caused to people, and the active ingredients in the existing cosmetics are low in effective utilization rate, so that the hyaluronic acid cosmetics cannot have the effect of conditioning the skin.
Disclosure of Invention
In order to solve the above technical problems, a first aspect of the present invention provides a moisturizing and moisturizing conditioning composition, which comprises at least: the skin conditioner and the humectant are mixed according to the weight ratio of 1: (1-2);
the humectant at least comprises one of glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium;
the skin conditioning agent comprises at least one of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, and a fourth skin conditioning agent; the weight ratio of the first skin conditioning agent, the second skin conditioning agent, the third skin conditioning agent and the fourth skin conditioning agent is (5-15): (0.5-1.5): (0.5-1.5): 1.
as a preferable technical scheme, the humectant disclosed by the invention is a composition comprising glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium; the weight ratio of the glycerol, the 1, 2-pentanediol, the sodium hyaluronate, the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, the caprylyl glycol, the ethylhexyl glycerol and the PCA sodium is (1-5): (1-3): (1-3): 1: (0.05-0.35): (0.1-1): (0.005-0.1).
In a preferred embodiment, the first skin conditioner of the present invention comprises at least one of 1, 2-hexanediol, p-hydroxyacetophenone, and biogel-1.
As a preferred technical solution, the second skin conditioner in the present invention at least includes one of yeast fermentation product filtrate and ethylhexyl glycerin.
In a preferred embodiment, the third skin conditioning agent comprises at least one of polyglycerol-10 myristate, phenoxyethanol, ceramide 2, cholesterol, and tocopherol.
In a preferred embodiment, the fourth skin conditioner of the present invention comprises at least a lactic acid bacteria fermentation lysate.
According to a second aspect of the invention, a daily chemical product comprising the moisturizing and moisturizing conditioning composition is provided, and the daily chemical product is selected from at least one of essence, lotion, face cream, toner, facial mask liquid, hand cream and eye cream.
The third aspect of the invention provides hyaluronic acid toner containing the moisturizing and moisturizing conditioning composition, which comprises the following raw materials in percentage by weight: 5-20% of the moistening and moisturizing conditioning composition, 0.05-2.5% of film-forming agent, 0.01-1.5% of solubilizer, 0.01-2.5% of essence and the balance of water.
The fourth aspect of the invention provides hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition, which comprises the following raw materials in percentage by weight: 10-25% of the moistening and moisturizing conditioning composition, 0.1-3.5% of film-forming agent, 0.05-2.5% of thickening agent, 0.01-1.5% of solubilizer, 0.01-2.5% of essence and the balance of water.
The fifth aspect of the invention provides a preparation method of the hyaluronic acid essence, which at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 5-35 minutes, and heating to 40-60 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 5-35 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 5-30 min to obtain uniform solution;
(4) cooling to 25-35 deg.C, adding the second skin conditioner, the third skin conditioner, the fourth skin conditioner, sodium PCA, essence and the rest raw materials, and stirring for 5-35 min;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a moisturizing and moisturizing conditioning composition which can be used for various different types of daily chemical articles, and the inventor finds that the composition is particularly applied to the preparation of hyaluronic acid essence, so that the process is simple, the production efficiency is high, and the excellent moisturizing performance is achieved. The technical core of the high-sand chiral stereoselective asymmetric synthesis method is adopted, so that the hyaluronic acid essence compounded with the ceramide has high optical activity, and on one hand, the effective utilization rate of the ceramide can be enhanced; on the other hand, the surface layer barrier is used for maintaining and conditioning the skin state to realize the youth state of the skin.
Drawings
FIG. 1 is a comparison between before and after using hyaluronic acid essence prepared in example 1; wherein, the left side in fig. 1 is before use, and the right side is after use.
Detailed Description
The technical features of the technical solutions provided by the present invention will be further clearly and completely described below with reference to the specific embodiments, and it should be apparent that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
The words "preferred", "preferably", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In a first aspect of the present invention, there is provided a moisturizing and moisturizing conditioning composition, comprising at least: the skin conditioner and the humectant are mixed according to the weight ratio of 1: (1-2);
the humectant at least comprises one of glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium;
the skin conditioning agent comprises at least one of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, and a fourth skin conditioning agent; the weight ratio of the first skin conditioning agent, the second skin conditioning agent, the third skin conditioning agent and the fourth skin conditioning agent is (5-15): (0.5-1.5): (0.5-1.5): 1.
in some preferred embodiments, the moisturizing conditioning composition comprises at least the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: 1.3;
the skin conditioning agent comprises at least one of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, and a fourth skin conditioning agent; the weight ratio of the first skin conditioner to the second skin conditioner to the third skin conditioner to the fourth skin conditioner is 10: 1: 1: 1.
in some embodiments, the moisturizer is a composition comprising glycerin, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, caprylyl glycol, ethylhexyl glycerin, sodium PCA; the weight ratio of the glycerol, the 1, 2-pentanediol, the sodium hyaluronate, the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, the caprylyl glycol, the ethylhexyl glycerol and the PCA sodium is (1-5): (1-3): (1-3): 1: (0.05-0.35): (0.1-1): (0.005-0.1).
In some preferred embodiments, the weight ratio of glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol, sodium PCA is 3: 2: 2: 1: 0.15: 0.2: 0.01.
in some embodiments, the first skin conditioning agent comprises at least one of 1, 2-hexanediol, p-hydroxyacetophenone, biosaccharide gum-1.
In some preferred embodiments, the first skin conditioning agent comprises at least a mixture of 1, 2-hexanediol, p-hydroxyacetophenone, biogel-1.
In the present invention, the source of the first skin conditioner is not particularly limited, and preferably, the first skin conditioner is purchased from Nexira brand under the trade name of NexPC FUCOSE GUM 300.
In some embodiments, the second skin conditioning agent comprises at least one of yeast fermentation product filtrate, ethyl hexyl glycerol.
In some preferred embodiments, the second skin conditioning agent comprises at least a mixture of yeast fermentation product filtrate, ethyl hexyl glycerol.
In the invention, the source of the second skin conditioner is not specially limited, and preferably, the brand of the second skin conditioner is Angel and the brand number is E-100.
In some embodiments, the third skin conditioning agent comprises at least one of polyglycerol-10 myristate, phenoxyethanol, ceramide 2, cholesterol, tocopherol.
In some preferred embodiments, the third skin conditioning agent comprises at least a mixture of polyglycerol-10 myristate, phenoxyethanol, ceramide 2, cholesterol, tocopherol.
In the present invention, the source of the third skin conditioner is not particularly limited, and preferably, the brand name of the third skin conditioner is Sinerga, and the brand name is Tri-Solve.
In some embodiments, the fourth skin conditioning agent comprises at least a lactic acid bacteria fermentation lysate.
In the present invention, the source of the fourth skin conditioner is not particularly limited, and preferably, the fourth skin conditioner is purchased from a trade name CLR and a trade name ProRenew Complex CLR.
The invention applies the technical core of a high sand chiral stereoselective asymmetric synthesis method, so that the hyaluronic acid essence compounded by ceramide has high optical activity, and the stereoselectivity can generate two stereoisomers with unequal amounts by the same reactant in an organic reaction, wherein when the amount of one stereoisomer is far superior to that of the other stereoisomer, the reaction is called to have stereoselectivity. Asymmetric synthesis is an organic reaction in which an achiral unit in the bulk of a substrate molecule is converted to a chiral unit by a reactant in a way that yields unequal amounts of stereoisomeric product.
According to a second aspect of the invention, a daily chemical product comprising the moisturizing and moisturizing conditioning composition is provided, and the daily chemical product is selected from at least one of essence, lotion, face cream, toner, facial mask liquid, hand cream and eye cream.
The third aspect of the invention provides hyaluronic acid toner containing the moisturizing and moisturizing conditioning composition, which comprises the following raw materials in percentage by weight: 5-20% of the moistening and moisturizing conditioning composition, 0.05-2.5% of film-forming agent, 0.01-1.5% of solubilizer, 0.01-2.5% of essence and the balance of water.
In some preferred embodiments, the hyaluronic acid toner containing the moisturizing and conditioning composition comprises the following raw materials in percentage by weight: 15 percent of the moistening and moisturizing conditioning composition, 0.15 percent of film forming agent, 0.05 percent of solubilizer, 0.1 percent of essence and the balance of water.
The fourth aspect of the invention provides hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition, which comprises the following raw materials in percentage by weight: 10-25% of the moistening and moisturizing conditioning composition, 0.1-3.5% of film-forming agent, 0.05-2.5% of thickening agent, 0.01-1.5% of solubilizer, 0.01-2.5% of essence and the balance of water.
In some preferred embodiments, the hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition comprises the following raw materials in percentage by weight: 15 percent of the moistening and moisturizing conditioning composition, 0.5 percent of film-forming agent, 0.3 percent of thickening agent, 0.07 percent of solubilizer, 0.1 percent of essence and the balance of water.
The film forming agent in the present invention is not particularly limited, and preferably, the film forming agent is an ammonium acryloyldimethyltaurate/VP copolymer.
The thickener in the present invention is not particularly limited, and preferably, the thickener is xanthan gum.
The solubilizer is not particularly limited in the present invention, and preferably, the solubilizer is a combination of PPG-26-butyether-26 and PEG-40 hydrogenated castor oil, and more preferably LRI.
The fifth aspect of the invention provides a preparation method of the hyaluronic acid essence, which at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 5-35 minutes, and heating to 40-60 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 5-35 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 5-30 min to obtain uniform solution;
(4) cooling to 25-35 deg.C, adding the second skin conditioner, the third skin conditioner, the fourth skin conditioner, sodium PCA, essence and the rest raw materials, and stirring for 5-35 min;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
In some preferred embodiments, the preparation method of the hyaluronic acid essence at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 15 minutes, and heating to 50 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 15 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 10 min to obtain uniform solution;
(4) cooling to 30 ℃, respectively adding a second skin conditioner, a third skin conditioner, a fourth skin conditioner, sodium PCA, essence and the rest raw materials, and continuously stirring for 15 minutes until the mixture is completely uniform;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
The present invention is described in detail below by way of examples, and it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention.
Example 1
A moistening and moisturizing conditioning composition at least comprises the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: 1.3;
the skin conditioning agent comprises a combination of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, a fourth skin conditioning agent; the weight ratio of the first skin conditioner to the second skin conditioner to the third skin conditioner to the fourth skin conditioner is 10: 1: 1: 1. the first skin conditioner was purchased from the manufacturer as Nexira and under the designation NexPC FUCOSEGUM 300. The second skin conditioner is Anqi brand with a brand number of E-100. The third skin conditioner is branded as Sinerga and Tri-Solve. The fourth skin conditioner was purchased from the manufacturer under the designation CLR and under the designation prorenewcomplete CLR.
The humectant is a composition comprising glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium; the weight ratio of the glycerol to the 1, 2-pentanediol to the sodium hyaluronate to the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol to the octyl glycol to the ethylhexyl glycerol to the PCA sodium is 3: 2: 2: 1: 0.15: 0.2: 0.01.
the hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition comprises the following raw materials in percentage by weight: 15 percent of the moistening and moisturizing conditioning composition, 0.5 percent of film-forming agent, 0.3 percent of thickening agent, 0.07 percent of solubilizer, 0.1 percent of essence and the balance of water. The film forming agent is acryloyl dimethyl ammonium taurate/VP copolymer. The thickening agent is xanthan gum. The solubilizer is LRI.
The preparation method of the hyaluronic acid essence at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 15 minutes, and heating to 50 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 15 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 10 min to obtain uniform solution;
(4) cooling to 30 ℃, respectively adding a second skin conditioner, a third skin conditioner, a fourth skin conditioner, sodium PCA, essence and the rest raw materials, and continuously stirring for 15 minutes until the mixture is completely uniform;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
Example 2
A moistening and moisturizing conditioning composition at least comprises the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: 1;
the skin conditioning agent comprises a combination of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, a fourth skin conditioning agent; the weight ratio of the first skin conditioner to the second skin conditioner to the third skin conditioner to the fourth skin conditioner is 5: 0.5: 0.5: 1. the first skin conditioner was purchased from the manufacturer as Nexira and under the designation NexPC FUCOSEGUM 300. The second skin conditioner is Anqi brand with a brand number of E-100. The third skin conditioner is branded as Sinerga and Tri-Solve. The fourth skin conditioner was purchased from the manufacturer under the designation CLR and under the designation prorenewcomplete CLR.
The humectant is a composition comprising glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium; the weight ratio of the glycerol to the 1, 2-pentanediol to the sodium hyaluronate to the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol to the octyl glycol to the ethylhexyl glycerol to the PCA sodium is 1: 1: 1: 1: 0.05: 0.1: 0.005.
the hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition comprises the following raw materials in percentage by weight: 10 percent of the moisturizing conditioning composition, 0.1 percent of film-forming agent, 0.05 percent of thickening agent, 0.01 percent of solubilizer, 0.01 percent of essence and the balance of water. The film forming agent is acryloyl dimethyl ammonium taurate/VP copolymer. The thickening agent is xanthan gum. The solubilizer is LRI.
The preparation method of the hyaluronic acid essence at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 35 minutes, and heating to 40 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 35 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 30 min to obtain uniform solution;
(4) cooling to 30 ℃, respectively adding a second skin conditioner, a third skin conditioner, a fourth skin conditioner, sodium PCA, essence and the rest raw materials, and continuously stirring for 35 minutes until the mixture is completely uniform;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
Example 3
A moistening and moisturizing conditioning composition at least comprises the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: 2;
the skin conditioning agent comprises a combination of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, a fourth skin conditioning agent; the weight ratio of the first skin conditioner to the second skin conditioner to the third skin conditioner to the fourth skin conditioner is 15: 5: 5: 1. the first skin conditioner was purchased from the manufacturer as Nexira and under the designation NexPC FUCOSEGUM 300. The second skin conditioner is Anqi brand with a brand number of E-100. The third skin conditioner is branded as Sinerga and Tri-Solve. The fourth skin conditioner was purchased from the manufacturer under the designation CLR and under the designation prorenewcomplete CLR.
The humectant is a composition comprising glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium; the weight ratio of the glycerol to the 1, 2-pentanediol to the sodium hyaluronate to the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol to the octyl glycol to the ethylhexyl glycerol to the PCA sodium is 5: 3: 3: 1: 0.35: 1: 0.1.
the hyaluronic acid essence containing the moisturizing and moisturizing conditioning composition comprises the following raw materials in percentage by weight: 25 percent of the moisturizing conditioning composition, 3.5 percent of film-forming agent, 2.5 percent of thickening agent, 1.5 percent of solubilizer, 2.5 percent of essence and the balance of water. The film forming agent is acryloyl dimethyl ammonium taurate/VP copolymer. The thickening agent is xanthan gum. The solubilizer is LRI.
The preparation method of the hyaluronic acid essence at least comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 15 minutes, and heating to 50 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 15 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 10 min to obtain uniform solution;
(4) cooling to 30 ℃, respectively adding a second skin conditioner, a third skin conditioner, a fourth skin conditioner, sodium PCA, essence and the rest raw materials, and continuously stirring for 15 minutes until the mixture is completely uniform;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
Performance testing
1. The hyaluronic acid essence prepared in example 1 was used, and the results of comparison before and after use are shown in fig. 1.
The using method comprises the following steps: the medicine is taken in the morning and at the evening each day; the using time is as follows: one month;
2. and (3) microbial detection: the hyaluronic acid essence prepared in example 1 was subjected to a microbiological test, and the test results are shown in table 1.
TABLE 1 microbiological test results
3. And (3) sanitary chemical inspection: the hyaluronic acid essence prepared in example 1 was subjected to the hygienic chemical examination, and the examination results are shown in table 2.
TABLE 2 sanitary chemistry test results
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content disclosed above into an equivalent embodiment with equivalent changes, but all those simple modifications, equivalent changes and modifications made on the above embodiment according to the technical spirit of the present invention still belong to the protection scope of the present invention.
Claims (10)
1. The moisturizing and moisturizing conditioning composition is characterized by at least comprising the following raw materials: the skin conditioner and the humectant are mixed according to the weight ratio of 1: (1-2);
the humectant at least comprises one of glycerol, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, caprylyl glycol, ethylhexyl glycerol and PCA sodium;
the skin conditioning agent comprises at least one of a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, and a fourth skin conditioning agent; the weight ratio of the first skin conditioning agent, the second skin conditioning agent, the third skin conditioning agent and the fourth skin conditioning agent is (5-15): (0.5-1.5): (0.5-1.5): 1.
2. the moisturizing conditioning composition of claim 1, wherein the moisturizer is a composition comprising glycerin, 1, 2-pentanediol, sodium hyaluronate, PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, caprylyl glycol, ethylhexyl glycerin, sodium PCA; the weight ratio of the glycerol, the 1, 2-pentanediol, the sodium hyaluronate, the PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, the caprylyl glycol, the ethylhexyl glycerol and the PCA sodium is (1-5): (1-3): (1-3): 1: (0.05-0.35): (0.1-1): (0.005-0.1).
3. The moisturizing conditioning composition of claim 1 or 2, wherein the first skin conditioning agent comprises at least one of 1, 2-hexanediol, p-hydroxyacetophenone, biogel-1.
4. The moisturizing conditioning composition of any of claims 1-3, wherein the second skin conditioning agent comprises at least one of yeast fermentation product filtrate, ethyl hexyl glycerol.
5. The moisturizing conditioning composition of any one of claims 1-3, wherein the third skin conditioning agent comprises at least one of polyglycerol-10 myristate, phenoxyethanol, ceramide 2, cholesterol, tocopherol.
6. The moisturizing conditioning composition of any one of claims 1-3, wherein the fourth skin conditioning agent comprises at least a lactic acid bacteria fermentation lysate.
7. A daily chemical article comprising the moisturizing and moisturizing conditioning composition as claimed in any one of claims 1 to 6, wherein the daily chemical article is selected from at least one of essence, lotion, cream, toner, facial mask solution, hand cream and eye cream.
8. A hyaluronic acid toner comprising the moisturizing and moisturizing conditioning composition as claimed in any one of claims 1 to 6, wherein the raw materials comprise, by weight: a moisturizing conditioning composition according to any one of claims 1 to 6, 0.05 to 2.5% of a film-forming agent, 0.01 to 1.5% of a solubilizer, 0.01 to 2.5% of a fragrance, and the balance water.
9. Hyaluronic acid serum comprising the moisturizing and moisturizing conditioning composition according to any one of claims 1 to 6, characterized in that the raw materials comprise, in weight percent: 10-25% of moisturizing conditioning composition according to any one of claims 1-6, 0.1-3.5% of film-forming agent, 0.05-2.5% of thickening agent, 0.01-1.5% of solubilizer, 0.01-2.5% of essence, and the balance of water.
10. The preparation method of hyaluronic acid essence of claim 9, which comprises the following steps:
(1) weighing the raw materials, adding water, a first skin conditioner, glycerol and sodium hyaluronate into a main tank, stirring for 5-35 minutes, and heating to 40-60 ℃ until the raw materials are dissolved and transparent;
(2) adding the film forming agent and the thickening agent into a main tank, stirring for 5-35 minutes, and checking whether particles exist;
(3) adding PEG/PPG/polytetramethylene glycol-8/5/3 glycerol, and stirring for 5-30 min to obtain uniform solution;
(4) cooling to 25-35 deg.C, adding the second skin conditioner, the third skin conditioner, the fourth skin conditioner, sodium PCA, essence and the rest raw materials, and stirring for 5-35 min;
(5) and finally, filtering, discharging, inspecting, filling, packaging and warehousing.
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| CN116139040A (en) * | 2022-12-26 | 2023-05-23 | 科乐美(广州)生物科技有限公司 | Moisturizing composition, moisturizing essence and preparation method of moisturizing essence |
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| Title |
|---|
| 深圳沃尔沃生物科技有限公司: "XEQ方程式 酵母玻尿酸精华液", 《国产非特殊用途化妆品备案信息服务平台》, 5 September 2019 (2019-09-05) * |
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|---|---|---|---|---|
| CN116139040A (en) * | 2022-12-26 | 2023-05-23 | 科乐美(广州)生物科技有限公司 | Moisturizing composition, moisturizing essence and preparation method of moisturizing essence |
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