CN109010100A - A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition - Google Patents

A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition Download PDF

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CN109010100A
CN109010100A CN201811039083.XA CN201811039083A CN109010100A CN 109010100 A CN109010100 A CN 109010100A CN 201811039083 A CN201811039083 A CN 201811039083A CN 109010100 A CN109010100 A CN 109010100A
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acne
liposome
skin
removing composition
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黄犟兵
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14Liposomes; Vesicles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23Sulfur; Selenium; Tellurium; Compounds thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/678Tocopherol, i.e. vitamin E
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
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    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
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Abstract

The present invention relates to a kind of acne-removing composition, the acne-removing composition includes following components in parts by weight: 1.0~5.0 parts of salicylic acid liposome, 1.0~5.0 parts of ceramide liposome, 1.0~5.0 parts of sulphur liposome, 1.0~5.0 parts of camellia seed oil, 1.0~10 parts of beta glucan, 1.0~5.0 parts of vitamin E and 0.2~1.0 part of peppermint;It mutually promotes between each ingredient of composition provided by the present invention, collaboration plays effect, by the grease balance for improving the moistening effect of skin, adjusting skin, the effect of inhibiting the excessive secretion of sebum, breeding, anti-inflammatory effect, the anti-acne print interaction of propionibacterium acnes inhibited to reach comprehensive anti-acne;It is rapidly achieved lesion portion, prevents grease blocking pore from further deteriorating the skin of inflammation;Pore refining Bergamot Mint Extract has significant suppression mite antibacterial and anti-inflammatory effects;The barrier function of skin is repaired and improved comprehensively, the wound healing time is shortened and reduces the formation of scar, enables the smooth exquisiteness of skin.

Description

A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition
Technical field
The present invention relates to cosmetic technical fields, anti-more particularly, to a kind of acne-removing composition and the anti-acne containing the composition Allergy frost and preparation method.
Background technique
Acne is being commonly called as acne, also known as " whelk ", " dark sore " or " acne ", be betide pilosebaceous follicle one kind it is slow Property diseases associated with inflammation, be in Young Patients it is most common influence beauty skin disease promote skin since internal male sex hormone increases Rouge secretion is vigorous, and the occlusion of hair follicle sebum glandular tube adds bacteria attack, so as to cause its generation, the morbidity of acne and inherent cause, It is hormone secretion, gastrointestinal disorders, related using medicine for external application, cosmetics improper use etc..
The fash that acne is most basic, most originates is acne, and there are two types of acne, and one is closed acne of not head, that is, white Head acne, it appears that be yellowish-white color dot or goose pimples;Another kind is open comedones, that is, blackhead, and opening has a stain. Whiteheads are the predecessors of blackhead, but many Whiteheads very " conservative ", not open to the outside world throughout one's life.It, can shape from acne At or be converted into papule, running sore, tubercle, tumour, and with seborrhea, above-mentioned fash has a three classes result: acne, uninfected Papule, lesser tubercle and the small running sore of superficial, can leave no trace after disappearance, or only dotted pigmentation and temporary small scar;Disorderly Choose acne, hustle running sore, after originally larger running sore (containing tumour) disappears, leave more the syringe needle size not disappeared intensively be recessed or with The hard sore of the suitable size of mung bean grain;Tumour, especially ulceration person leave not only big not only deep but also irregular streak scar, and quality is very Firmly, the appearance for seriously affecting people has an important influence on the employment, social activity and marriage and childbirth etc. of normal person.It is now recognized that acne It falls ill related with androgen levels, sebum secretion increase, hair follicle conduit hyperkeratinization, propionibacterium acnes infection.Medically Treatment is often with vitamins, endocrine preparation, antibiotics treatment, but effect is barely satisfactory, wherein some drug pairs are made With obvious.
Therefore, product for resolving poxes in the market is more and more, however generally existing specific aim is not strong, and effect is unconspicuous to be lacked Point, consumer are difficult to select, and most product for resolving poxes slow effect can not although certain anti-acne effect can be played Inhibit the breeding of the excessive secretion and propionibacterium acnes of sebum, therefore after anti-acne, skin surface still there are acne print or Scar, product for resolving poxes in the market are more and more;In addition, treatment medically is often with vitamins, endocrine preparation, antibiotic Class drug therapy, but effect is barely satisfactory, wherein some drug side effects are obvious, it is therefore desirable to improve.
Summary of the invention
In view of the deficienciess of the prior art, the object of the present invention is to provide a kind of acne-removing composition, the acne-removing composition The grease balance for improving the moistening effect of skin, adjusting skin inhibits the excessive secretion of sebum, inhibits the numerous of propionibacterium acnes It grows, anti-inflammatory anti-acne print.
To achieve the goals above, the technical scheme adopted by the invention is that:
A kind of acne-removing composition, the acne-removing composition include: 1.0~5.0 parts of salicylic acid liposome, neural acyl by weight 1.0~5.0 parts of amine liposome, 1.0~5.0 parts of sulphur liposome, 1.0~5.0 parts of camellia seed oil, 1.0~10 parts of beta glucan, 1.0~5.0 parts and 0.2~1.0 part of peppermint of vitamin E.
Further, the acne-removing composition includes: 2.0~4.0 parts of salicylic acid liposome, ceramide by weight 2.0~4.0 parts of liposome, 2.0~4.0 parts of sulphur liposome, 2.0~4.0 parts of camellia seed oil, 2.0~7.0 parts of beta glucan, 2.0~4.0 parts and 0.4~0.8 part of peppermint of vitamin E.
As a preferred embodiment of the present invention, the acne-removing composition includes: salicylic acid liposome 3.0 by weight Part, 3.0 parts of ceramide liposome, 3.0 parts of sulphur liposome, 3.0 parts of camellia seed oil, 5.0 parts of beta glucan, vitamin E 3.0 parts and 0.6 part of peppermint.
As a preferred embodiment of the present invention, the beta glucan selects β -1,3 glucans or β -1,6 glucans.
The bigcatkin willow sour component that the salicylic acid liposome contains is to extract from willow leaf or willow bark, so also crying willow Acid belongs to beta-hydroxy acid i.e. BHA in chemical structure, have sterilization, anti-inflammatory, relieve pain, lighten the stain, reduce pore, remove it is tiny The effect of wrinkle, is most basic, most effective beveling prime factor, can remove the horn cell of aging, and the cell of health is allowed to appear Come, so can achieve the effect that whitening and lighten the stain;In addition salicylic acid is fat-soluble thus can penetrate into inside pore, deeply Unclogging;Salicylic acid is dissolved into liposome interior, liposome is to reduce salicylic acid to the irritation of skin by the present invention A kind of artificial membrane, the bilayer structure having is identical as Skin Cell membrane structure, there is excellent moisture-keeping function to skin, and Have the characteristics that with cell membrane fusion, the salicylic acid wrapped can be sent directly into cell interior, thus reach attenuating pair The purpose of skin irritation.
The ceramide liposome has many-sided beautification skin containing Cer EOS, Cer NP, Cer AP The efficiency of skin has in terms of moisturizing, anti-inflammatory, antibacterial, antipruritic, antiallergy, softening skin, anti-acne, reconstruction Certain effect can make skin delicate, flexible, have the effects that anti-corrosion and delay senescence.
The sulphur liposome has antibacterial, anti-inflammatory, has anti-mite, eradicates the effects of skin itching disease, is used for a long time also not It can develop drug resistance, since sulphur itself has certain irritation to skin, be easy to cause patient of hypersensitivity, the present invention is by sulphur It is dissolved into liposome interior, the characteristics of using liposome and cell membrane fusion, the salicylic acid wrapped can be sent directly into Cell interior, to achieve the purpose that lower to skin irritation.
The camellia seed oil has the function of anti-inflammation and sterilization, is a kind of natural disinfectant, can thoroughly remove excess oil Secretion adjusts water and oil balance, helps to dispel acne, prevents small pox and accelerates recovery from illness, provides moisture content for skin while reinforcing thin Greasy repair ability promotes skin smooth, enables pore healthier careful.
The beta glucan is excellent immunoactivator, can promote langerhans' cells (Active Defending System Against of skin) Proliferation, enhances the immunocompetence of skin;Basal cell --- macrophage in beta glucan energy activating immune system, macrophage are thin Born of the same parents generate epidermal growth factor (EGF), thus promote collagen necessary to wound healing generate, while angiogenesis because Sub (AF) can promote neovascularization necessary to wound healing, there is unique bioactivity in terms of sensitive skin repair, for It eliminates acne print and promotes wound healing that there is obvious action.
The anti-acne antiallergic cream containing acne-removing composition of the present invention that it is another object of the present invention to provide a kind of And preparation method thereof, its technical solution is as follows: a kind of anti-acne antiallergic cream, and the anti-acne antiallergic cream includes: by weight 1.0~5.0 parts of salicylic acid liposome, 1.0~5.0 parts of ceramide liposome, 1.0~5.0 parts of sulphur liposome, camellia seed oil 1.0~5.0 parts, 1.0~10 parts of beta glucan, 1.0~5.0 parts of vitamin E, 0.2~1.0 part of peppermint, stereth -2 1-5 parts, 1~5 part of stereth -20, stearine and 1~5 part of PEG-100 stearate mixture, spermaceti are hard 1~5 part of lipidol, 1~5 part of saualane, 1~5 part of dimethyl silicone polymer;1~5 part of isopropyl myristate, Nipasol 0.10~2 part, 0.2~2 part of methyl hydroxybenzoate, 0.2~2 part of bisabolol, 1~5 part of glycerine, 1~5 part of urea, xanthan 0.1~2 part of glue, 1~3 part of propylene glycol, 0.5~10 part of marine algae extract and 0.5~5 part of purslane extract.
As a preferred embodiment of the present invention, the anti-acne antiallergic cream includes: salicylic acid liposome by weight 2.0~4.0 parts, 2.0~4.0 parts of ceramide liposome, 2.0~4.0 parts of sulphur liposome, 2.0~4.0 parts of camellia seed oil, 2.0~7.0 parts of beta glucan, 2.0~4.0 parts of vitamin E, 0.4~0.8 part of peppermint, 2.0~4.0 parts of stereth -2, 2.0~4.0 parts of stereth -20, stearine and 2.0~4.0 parts of PEG-100 stearate mixture, spermaceti 1.5~4.5 parts of stearyl alcohol, 1.5~4.5 parts of saualane, 2.0~4.0 parts of dimethyl silicone polymer, isopropyl myristate 1.5 ~4.5 parts, 0.15~1.8 part of Nipasol, 0.15~1.8 part of methyl hydroxybenzoate, 0.5~1.8 part of bisabolol, glycerine 2.0 ~4.0 parts, 2.0~4.0 parts of urea, 0.2~1.5 part of xanthan gum, 1.5~2.5 parts of propylene glycol, 2~8 parts of marine algae extract and horse 1.0~4.0 parts of sativa extract.
As a preferred embodiment of the present invention, the stearine and PEG-100 stearate mixture include The stearine and PEG-100 stearate mixed according to arbitrary proportion.
It further, further include 20~82.1 parts of deionized water.
The preparation method of above-mentioned anti-acne antiallergic cream the following steps are included:
S1, stereth -2, stereth -20, stearine and PEG-100 stearic acid are weighed according to formula ratio Ester, cetostearyl alcohol, saualane, dimethyl silicone polymer, isopropyl myristate, Nipasol, methyl hydroxybenzoate, bisabolol And peppermint, it puts into container, stirs, be uniformly mixed, and be heated to 80-85 DEG C, obtain component A, it is spare;
S2, glycerine, urea, xanthan gum, mixed with propylene glycol are weighed according to formula ratio, deionized water is added and stirs evenly, heats To 80 DEG C, B component is obtained, it is spare;
S3, camellia seed oil, vitamin E mixing are weighed according to formula ratio, stir evenly, obtain component C, it is spare;
S4, salicylic acid liposome, ceramide liposome, the mixing of sulphur liposome are weighed according to formula ratio, stir evenly, obtain D Component, it is spare;
S5, beta glucan, marine algae extract, purslane extract mixing are weighed according to formula ratio, stir evenly, obtain component E, it is standby With;
S6, after said components A, component B are uniformly mixed homogeneous, 50 DEG C are cooled to, and component C is added at such a temperature, stirring After homogeneous uniform, 40 DEG C are cooled to, component D and component E is added, is uniformly mixed and can be obtained finished product.
Compared with prior art, the invention has the benefit that between each ingredient of composition provided by 1, invention mutually Promote, collaboration plays effect, is balanced by the grease of the moistening effect of raising skin, adjusting skin, inhibits excessive point of sebum Secrete, inhibit the effect of breeding, anti-inflammatory effect, the anti-acne print interaction of propionibacterium acnes reaches comprehensive anti-acne;It can quickly reach To lesion portion, prevent grease blocking pore from further deteriorating the skin of inflammation, and can pore refining Sage Extract point It secretes, has significant suppression mite antibacterial and anti-inflammatory effects, the barrier function of skin can be repaired comprehensively and improve, when shortening wound healing Between and reduce the formation of scar, enable the smooth exquisiteness of skin, pass through the activity and reconstruction for inhibiting the acnes pathogenic bacteria such as Propiobacterium Skin barrier, thus the effect of reaching so that the problems of whelks;2, salicylic acid liposome used in acne eliminating cream of the present invention, neural acyl Amine liposome, sulphur lipid physical efficiency are maximally maintained its activity, the characteristics of using liposome and cell membrane fusion, maximum journey Irritation of the reduction of degree to skin.
Specific embodiment
It is only below presently preferred embodiments of the present invention, is not intended to limit the scope of the present invention.
The forming process of acne: some patientss fat secretion is vigorous, and often glossy to have one's face covered with, it is thick that grease excessively will lead to pore Greatly/blocking, smegma grease, cuticula thicken, and gradually swell toward cortical surface, cuticula protuberance;Since grease blocks hair The vertex oxidation in hole, protuberance becomes black, and together with bacterium is mixed in pore with grease, propionibacterium acnes are in anaerobic condition Lower mass propagation causes inflammation bacterium to invade, becomes warts, tubercle, and entire hair follicle reddens, inflammation, bacterium be diffused near Skin histology becomes much larger, and then forms acne.
For the heavy link of acne forming process, the present invention provides following several embodiments, forms source from acne On, acne is eradicated, acne recurrent exerbation is avoided.
Embodiment 1: acne-removing composition
The reason of for acne formation, the present invention provides a kind of acne-removing composition, and the acne-removing composition includes: by weight 1.0 parts of salicylic acid liposome, 1.0 parts of ceramide liposome, 1.0 parts of sulphur liposome, 1.0 parts of camellia seed oil, beta glucan 1.0 parts, 1.0 parts of vitamin E and 0.2 part of peppermint.
Embodiment 2: acne-removing composition
The acne-removing composition includes: 3 parts of salicylic acid liposome, 5 parts of ceramide liposome, sulphur liposome by weight 4 parts, 3 parts of camellia seed oil, 3 parts of beta glucan, 3 parts of vitamin E and 0.5 part of peppermint.
Embodiment 3: anti-acne antiallergic cream and preparation method thereof
Formula: the anti-acne antiallergic cream includes: 1.0 parts of salicylic acid liposome, ceramide liposome 1.0 in parts by weight Part, 1.0 parts of sulphur liposome, 1.0 parts of camellia seed oil, 1.0 parts of beta glucan, 1.0 parts of vitamin E, 0.2 part of peppermint, stearyl alcohol 1.0 parts of polyethers -2,1.0 parts of stereth -20, stearine and 1.0 parts of PEG-100 stearate, cetearyl alcohol 1.0 parts of alcohol, 1.0 parts of saualane, 1.0 parts of dimethyl silicone polymer, 1.0 parts of isopropyl myristate, 0.10 part of Nipasol, hydroxyl 0.2 part of benzene methyl, 0.2 part of bisabolol, 1.0 parts of glycerine, 1.0 parts of urea, 0.1 part of xanthan gum, 1.0 parts of propylene glycol, seaweed 0.5 part of extract, 0.5 part of purslane extract and 82.1 parts of deionized water.
Preparation: stereth -2, stereth -20, stearine and PEG- S1, are weighed according to formula ratio 100 stearates, cetostearyl alcohol, saualane, dimethyl silicone polymer, isopropyl myristate, Nipasol, oxybenzene first Ester, bisabolol and peppermint, put into container, stir, and are uniformly mixed, and be heated to 80-85 DEG C, obtain component A, spare;
S2, glycerine, urea, xanthan gum, mixed with propylene glycol are weighed according to formula ratio, deionized water is added and stirs evenly, heats To 80 DEG C, B component is obtained, it is spare;
S3, camellia seed oil, vitamin E mixing are weighed according to formula ratio, stir evenly, obtain component C, it is spare;
S4, salicylic acid liposome, ceramide liposome, the mixing of sulphur liposome are weighed according to formula ratio, stir evenly, obtain D Component, it is spare;
S5, beta glucan, marine algae extract, purslane extract mixing are weighed according to formula ratio, stir evenly, obtain component E, it is standby With;
S6, after said components A, component B are uniformly mixed homogeneous, 50 DEG C are cooled to, and component C is added at such a temperature, stirring After homogeneous uniform, 40 DEG C are cooled to, component D and component E is added, is uniformly mixed and can be obtained finished product.
Embodiment 4: anti-acne antiallergic cream and preparation method thereof
The anti-acne antiallergic cream includes: 3 parts of salicylic acid liposome, 5 parts of ceramide liposome, sulphur rouge in parts by weight 4 parts of plastid, 3 parts of camellia seed oil, 3 parts of beta glucan, 3 parts of vitamin E, 0.5 part of peppermint, 2.0 parts of stereth -2, tristearin 2.0 parts of -20 2.0 parts of alcohol polyethers, stearine and PEG-100 stearate, 3.0 parts of cetostearyl alcohol, saualane 2.0 Part, red does not have 2.0 parts of dimethyl silicone polymer, 2.0 parts of isopropyl myristate, 0.20 part of Nipasol, 0.2 part of methyl hydroxybenzoate 1.0 parts of medicine alcohol, 2.0 parts of glycerine, 3.0 parts of urea, 0.2 part of xanthan gum, 2.0 parts of propylene glycol, 3.0 parts of marine algae extract, dent 1.0 parts of amaranth extract, 50.9 parts of deionized water.
Preparation method is same as Example 3.
Comparative example 1: certain the brand Whelk-eliminating paste purchased on the market.
Clinical test:
Subjects: choose 150 whelk patients, male patient 72, female patient 78, the age between 18-28 years old, It is randomly divided into five groups, every group 30.
Skin: face has apparent acne and acne, without the record for using product for resolving poxes in test the last week.
Test method: all patients are boundary from face's medium line, are divided into left face and right face, before smearing that face is abundant It is clean, take suitable given the test agent to be uniformly applied to clean left face affected part, comparative example 1 is applied to clean right face Affected part is smeared 2 times daily, once in the morning and once at night, is tried out 2 weeks;Subject is kept for good daily schedule and diet in the trial employment period Habit, concrete outcome is see table 1~4.
The test result of table 1 embodiment 1 and comparative example 1
The test result of table 2 embodiment 2 and comparative example 1
The test result of table 3 embodiment 3 and comparative example 1
The test result of table 4 embodiment 4 and comparative example 1
By above table 1~4 it is found that in tested crowd, using the product in comparative example 1, the right face of tested crowd has one Determine the anti-acne effect of degree, the anti-acne print effect of most of experimenter is general, and almost without skin repair effect, in addition exists During use, there is the experimenter different degrees of allergic conditions occur.
Examples 1 to 4 redeployed product be applied to the left face of tested crowd, the tested crowd left side of almost all is on the face Acne dispel completely, after lasting use, the tested crowds of the overwhelming majority dispel effect to acne print and feel quite pleased, and have significant suppression Mite is antibacterial and anti-inflammatory effects, repairs and improve the barrier function of skin comprehensively, shortens the wound healing time and reduces scar It is formed, enables the smooth exquisiteness of skin, by inhibiting the activity of the acnes pathogenic bacteria such as Propiobacterium and rebuilding skin barrier, to reach The effect of so that the problems of whelks, wherein found according to test result, it is best that the so that the problems of whelks of embodiment 4 repair antiallergic effect.
It is practical to solve case:
Case 1:
Miss Wu, 24 years old, Yangzhou company clerk, 23 years old when, started dyssecretosis, in addition staying up late, eating fry, started Small pox constantly is emitted in two cheeks, forehead, causes great puzzlement.Many product for resolving poxes were tried, effect is all general.Use the present invention Product, second day sufferings degree is substantially reduced, small pox takes off red, and third day starts small pox and becomes smaller, and becomes small red seal after five days, adheres to It is finished 15 days acne prints, acne scar substantially eliminates.
Case 2:
Miss Chen, 22 years old, big two were reading student, and the long acne of cheek has a year and a half, tried many product for resolving poxes, and effect is all general, And skin is caused to be easy allergy, using product for resolving poxes of the invention, sufferings degree is substantially reduced within two days, general red mitigation, seven days small poxs It eliminates, acne print, acne scar substantially eliminate after 15 days.
Case 3:
Mr. Li, 23 years old, company clerk, the long acne of cheek 1 year, due to squeezing through common hand, face was general red serious, and 2017 9 The moon 12, facial small pox was mitigated by red dot within three days using my company's product for resolving poxes, and facial small pox is entirely good within seven days.Adhere to using 1 After a month, face absolutely not small pox, acne print.
Case 4:
Mr. Shi, 19 years old, Plant personnel, the long acne of cheek started long acne the year before, is slowly increasing later, used some Indigenous method, and strengthen in terms of diet note that still small pox is not under control, using product for resolving poxes of the invention, two days There is positive effect, facial small pox disappears within 6 days.Adhere to eliminating using 20 days face's small poxs, acne print.
In conclusion this product composition has the activity for inhibiting the acnes pathogenic bacteria such as Propiobacterium and rebuilds skin barrier Function, and not will lead to the skin allergy of user, thus the effect of reaching so that the problems of whelks.
The above is only a preferred embodiment of the present invention, for those of ordinary skill in the art, according to the present invention Thought, there will be changes in the specific implementation manner and application range, and the content of the present specification should not be construed as to the present invention Limitation.

Claims (10)

1. a kind of acne-removing composition, which is characterized in that the acne-removing composition includes: by weight
1.0~5.0 parts of salicylic acid liposome;1.0~5.0 parts of ceramide liposome;
1.0~5.0 parts of sulphur liposome;1.0~5.0 parts of camellia seed oil;
1.0~10 parts of beta glucan;1.0~5.0 parts of vitamin E;
0.2~1.0 part of peppermint.
2. a kind of acne-removing composition according to claim 1, which is characterized in that the acne-removing composition wraps by weight It includes:
2.0~4.0 parts of salicylic acid liposome;2.0~4.0 parts of ceramide liposome;
2.0~4.0 parts of sulphur liposome;2.0~4.0 parts of camellia seed oil;
2.0~7.0 parts of beta glucan;2.0~4.0 parts of vitamin E;
0.4~0.8 part of peppermint.
3. a kind of acne-removing composition according to claim 2, which is characterized in that the acne-removing composition wraps by weight It includes:
3.0 parts of salicylic acid liposome;3.0 parts of ceramide liposome;
3.0 parts of sulphur liposome;3.0 parts of camellia seed oil;
5.0 parts of beta glucan;3.0 parts of vitamin E;
0.6 part of peppermint.
4. a kind of acne-removing composition according to claim 3, which is characterized in that the beta glucan selects β -1, and 3 Portugals are poly- Sugar or β -1,6 glucan.
5. the acne-removing composition as described in claim 1-4 any claim is preparing the application in acne-eliminating cosmetic.
6. a kind of anti-acne antiallergic cream, which is characterized in that the anti-acne antiallergic cream includes: by weight
1.0~5.0 parts of salicylic acid liposome;1.0~5.0 parts of ceramide liposome;
1.0~5.0 parts of sulphur liposome;1.0~5.0 parts of camellia seed oil;
1.0~10 parts of beta glucan;1.0~5.0 parts of vitamin E;
0.2~1.0 part of peppermint;- 2 1-5 parts of stereth;
1~5 part of stereth -20;
Stearine and PEG-100
1~5 part of stearate mixture;1~5 part of cetostearyl alcohol;
1~5 part of saualane;
1~5 part of dimethyl silicone polymer;1~5 part of isopropyl myristate;
0.10~2 part of Nipasol;0.2~2 part of methyl hydroxybenzoate;
0.2~2 part of bisabolol;1~5 part of glycerine;
1~5 part of urea;0.1~2 part of xanthan gum;
1~3 part of propylene glycol;0.5~10 part of marine algae extract;
0.5~5 part of purslane extract.
7. a kind of anti-acne antiallergic cream according to claim 6, which is characterized in that the anti-acne antiallergic cream is by weight Meter includes:
2.0~4.0 parts of salicylic acid liposome;2.0~4.0 parts of ceramide liposome;
2.0~4.0 parts of sulphur liposome;2.0~4.0 parts of camellia seed oil;
2.0~7.0 parts of beta glucan;2.0~4.0 parts of vitamin E;
0.4~0.8 part of peppermint;2.0~4.0 parts of stereth -2;
2.0~4.0 parts of stereth -20;
Stearine and 2.0~4.0 parts of PEG-100 stearate mixture;
1.5~4.5 parts of cetostearyl alcohol;1.5~4.5 parts of saualane;
2.0~4.0 parts of dimethyl silicone polymer;1.5~4.5 parts of isopropyl myristate;
0.15~1.8 part of Nipasol;0.15~1.8 part of methyl hydroxybenzoate;
0.5~1.8 part of bisabolol;2.0~4.0 parts of glycerine;
2.0~4.0 parts of urea;0.2~1.5 part of xanthan gum;
1.5~2.5 parts of propylene glycol;2~8 parts of marine algae extract;
1.0~4.0 parts of purslane extract.
8. a kind of anti-acne antiallergic cream according to claim 6 or 7, which is characterized in that the stearine and PEG-100 stearate mixture includes the stearine and PEG-100 stearate mixed according to arbitrary proportion.
9. a kind of anti-acne antiallergic cream according to claim 8, which is characterized in that further include deionized water 20~82.1 Part.
10. a kind of preparation method of anti-acne antiallergic cream as claimed in claim 9, which comprises the following steps:
S1, stereth -2, stereth -20, stearine and PEG-100 stearic acid are weighed according to formula ratio Ester, cetostearyl alcohol, saualane, dimethyl silicone polymer, isopropyl myristate, Nipasol, methyl hydroxybenzoate, bisabolol And peppermint, it puts into container, stirs, be uniformly mixed, and be heated to 80-85 DEG C, obtain component A, it is spare;
S2, glycerine, urea, xanthan gum, mixed with propylene glycol are weighed according to formula ratio, deionized water is added and stirs evenly, heats To 80 DEG C, B component is obtained, it is spare;
S3, camellia seed oil, vitamin E mixing are weighed according to formula ratio, stir evenly, obtain component C, it is spare;
S4, salicylic acid liposome, ceramide liposome, the mixing of sulphur liposome are weighed according to formula ratio, stir evenly, obtain D Component, it is spare;
S5, beta glucan, marine algae extract, purslane extract mixing are weighed according to formula ratio, stir evenly, obtain component E, it is standby With;
S6, after said components A, component B are uniformly mixed homogeneous, 50 DEG C are cooled to, and component C is added at such a temperature, stirring After homogeneous uniform, 40 DEG C are cooled to, component D and component E is added, is uniformly mixed and can be obtained finished product.
CN201811039083.XA 2018-09-06 2018-09-06 A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition Pending CN109010100A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110269929A (en) * 2019-08-13 2019-09-24 滨海昌正企业管理有限公司 Have effects that the composition of skin repair and its application in cosmetics
CN110538088A (en) * 2019-08-30 2019-12-06 西安博和医疗科技有限公司 skin care composition and preparation method thereof
CN110946770A (en) * 2020-01-16 2020-04-03 厦门泽本健康管理有限公司 Acne-removing cream with liquid crystal structure and preparation method thereof
CN113368018A (en) * 2020-03-10 2021-09-10 盈妆生物科技(上海)有限公司 Anti-inflammatory acne-removing composition and preparation method thereof
CN113384498A (en) * 2020-03-13 2021-09-14 石家庄以岭药业股份有限公司 Acne-removing composition and preparation method thereof
CN113662878A (en) * 2021-08-26 2021-11-19 广东丸美生物技术股份有限公司 Lipid-containing anti-aging skin-care matrix and application thereof
CN113712836A (en) * 2020-12-30 2021-11-30 深圳市巴斯星科技有限公司 Anti-inflammatory acne-removing skin care composition and preparation method and using method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1111984A (en) * 1995-04-26 1995-11-22 广东医学院医药科技开发中心 Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions
CN103565714A (en) * 2013-10-15 2014-02-12 深圳市瓜芬生物科技有限公司 Acne removing and antiallergic cream and preparation method thereof
CN105380867A (en) * 2015-12-27 2016-03-09 青岛克立克信息技术有限公司 Acne removal facial cleanser
CN105412731A (en) * 2015-12-23 2016-03-23 葛红芬 Ointment for treating skin pruritus and preparing method thereof
CN107260584A (en) * 2017-06-15 2017-10-20 南通蛇类治疗研究所 Natural plants Nano Silver system snake gall acne eliminating cream
CN107595713A (en) * 2017-10-27 2018-01-19 丘少荣 A kind of great burdock achene acne eliminating cream and preparation method thereof
CN107684530A (en) * 2017-08-25 2018-02-13 深圳市雪绒蓝天化妆品贸易有限公司 Acne-removing composition and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1111984A (en) * 1995-04-26 1995-11-22 广东医学院医药科技开发中心 Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions
CN103565714A (en) * 2013-10-15 2014-02-12 深圳市瓜芬生物科技有限公司 Acne removing and antiallergic cream and preparation method thereof
CN105412731A (en) * 2015-12-23 2016-03-23 葛红芬 Ointment for treating skin pruritus and preparing method thereof
CN105380867A (en) * 2015-12-27 2016-03-09 青岛克立克信息技术有限公司 Acne removal facial cleanser
CN107260584A (en) * 2017-06-15 2017-10-20 南通蛇类治疗研究所 Natural plants Nano Silver system snake gall acne eliminating cream
CN107684530A (en) * 2017-08-25 2018-02-13 深圳市雪绒蓝天化妆品贸易有限公司 Acne-removing composition and preparation method thereof
CN107595713A (en) * 2017-10-27 2018-01-19 丘少荣 A kind of great burdock achene acne eliminating cream and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
梁治齐: "《微胶囊技术及其应用》", 30 April 1999, 中国轻工业出版社 *
王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *
裘炳毅等: "《现代化妆品科学与技术》", 31 March 2016, 中国轻工业出版社 *
谭庆梅等: "《完全护肤手册》", 30 July 2006, 上海科学技术出版社 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110269929A (en) * 2019-08-13 2019-09-24 滨海昌正企业管理有限公司 Have effects that the composition of skin repair and its application in cosmetics
CN110269929B (en) * 2019-08-13 2021-11-02 昌正医疗(苏州)有限公司 Composition with skin repairing effect and application thereof in cosmetics
CN110538088A (en) * 2019-08-30 2019-12-06 西安博和医疗科技有限公司 skin care composition and preparation method thereof
CN110946770A (en) * 2020-01-16 2020-04-03 厦门泽本健康管理有限公司 Acne-removing cream with liquid crystal structure and preparation method thereof
CN113368018A (en) * 2020-03-10 2021-09-10 盈妆生物科技(上海)有限公司 Anti-inflammatory acne-removing composition and preparation method thereof
CN113384498A (en) * 2020-03-13 2021-09-14 石家庄以岭药业股份有限公司 Acne-removing composition and preparation method thereof
CN113384498B (en) * 2020-03-13 2023-08-08 石家庄以岭药业股份有限公司 Acne-removing composition and preparation method thereof
CN113712836A (en) * 2020-12-30 2021-11-30 深圳市巴斯星科技有限公司 Anti-inflammatory acne-removing skin care composition and preparation method and using method thereof
CN113662878A (en) * 2021-08-26 2021-11-19 广东丸美生物技术股份有限公司 Lipid-containing anti-aging skin-care matrix and application thereof

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Application publication date: 20181218