CN108392434A - A kind of silk-extract and whitening spot-eliminating composition and preparation method containing it - Google Patents
A kind of silk-extract and whitening spot-eliminating composition and preparation method containing it Download PDFInfo
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- CN108392434A CN108392434A CN201810422200.4A CN201810422200A CN108392434A CN 108392434 A CN108392434 A CN 108392434A CN 201810422200 A CN201810422200 A CN 201810422200A CN 108392434 A CN108392434 A CN 108392434A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a kind of silk-extracts.The invention discloses a kind of whitening spot-eliminating compositions, including silk-extract, Gotu Kola P.E, Matrixyl 20, saccharomycete lysis object extract, Cer NP.The present invention provides a kind of whitening spot-removing creams, by weight percentage, including the following raw material：Functional component 2.4 30%, glycerine 1 5%, emulsifier 1 5%, grease 5 23%, thickener 2 8%, triethanolamine 0.1 2%, 1,2 pentanediols 1 3%, surplus is deionized water, wherein, the functional component includes silk-extract, Gotu Kola P.E, Matrixyl 20, saccharomycete lysis object extract, Cer NP.The invention also discloses a kind of preparation methods of whitening spot-removing creams.Whitening spot-removing creams provided by the invention play synergistic function between each raw material, and whitening spot-removing creams whitening spot-removing ability obtained is strong, while also having many advantages, such as that property is mild, irritation is small, it is high to moisten degree, easily absorbing, safe without toxic side effect.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of silk-extract and the whitening spot-removing combination containing it
Object and preparation method.
Background technology
Because in skin hyperpigmentation due to make occur the spot different with ambient color on skin, referred to as color spot, for a long time with
Come the big problem for always perplexing human skin.Color spot includes freckle, sunburn, blackspot, chloasma and senile plaque etc., belongs to pigment
Obstacle dermatoses.Ultraviolet light irradiation, sleeping time is unstable, computer radiation, disorder of hormone secretion, abuse cosmetics, makes up
Product improper use, environmental pollution etc. may cause skin surface pigment anomaly calm and form color spot.
Tyrosinase is a kind of metalloenzyme of cupric, and tyrosinase is the key enzyme of B16 cell, the enzyme of tyrosinase
Activity is stronger, and the melanin of generation is more, otherwise fewer.Therefore, the technical principle for lightening the stain core the most is to pass through
Inhibit the enzymatic activity of tyrosinase and generated pigment is accelerated to decompose, the nti-freckle active material being widely used at present has bear
Fruit glycosides, vitamin C and its derivative.Ursin (Arbutine) also known as Arbutin extract the leaf from black bearberry, can speed up
The decomposition and excretion of melanin to reduce Skin pigmentation, dispelling stain and freckle, while also having the work of sterilization, anti-inflammatory
With.Vitamin C (Vitamin C) has anti-oxidant, anti-inflammatory effect, can promote the absorption of collagen, skin is made to restore to live
Power；Melanin in decomposable asymmetric choice net skin prevents pigmentation, contributes to even skin tone and keep skin careful.
The ability that such active material has the enzymatic activity of certain inhibition tyrosine and pigment is accelerated to decompose, to reach
Whitening spot-removing effect, but have certain irritation, part is sensitive, more sensitive skin crowd cannot be used for a long time.
Invention content
It is of the existing technology in order to solve the problems, such as, the purpose of the present invention is to provide a kind of safety and there is whitening spot-removing
The silk-extract of effect.The present invention provides a kind of whitening spot-eliminating composition and whitening spot-removing creams, the creams nti-freckle abilities
By force, it and does not stimulate mildly, safe without toxic side effect, is suitble to that part is sensitive, more sensitive skin crowd uses.The present invention also provides
A kind of preparation method of whitening spot-removing creams.
To achieve the above object, the first aspect of the present invention provides a kind of silk-extract, the silk-extract by
Following steps are made：
Silk cocoon is after over cleaning infiltrates, with 1:40-60 bath raioes enter water, and in 0.1-0.15MPa, 110-130 DEG C handles 2-3h,
Filtering, after filtrate is freeze-dried, obtains silk-extract.
The second aspect of the present invention provides a kind of whitening spot-eliminating composition, and the whitening spot-eliminating composition includes above-mentioned
Silk-extract, Gotu Kola P.E, Matrixyl -20, saccharomycete lysis object extract, ceramide -3.
Further, in parts by weight, the whitening spot-eliminating composition include above-mentioned 2-20 parts of silk-extract,
0.1-2 parts of Gotu Kola P.E, -20 0.1-2 parts of Matrixyl, 0.1-3 parts of saccharomycete lysis object extract, ceramide -
3 0.1-3 parts.
The third aspect of the present invention provides a kind of whitening cosmetics, using above-mentioned whitening spot-eliminating composition as effect
Ingredient.
Further, the whitening cosmetics include any one of creams, lotion, facial mask.
Further, the whitening cosmetics are creams, and by weight percentage, the whitening spot-removing creams include such as
Lower raw material：Functional component 2.4-30%, glycerine 1-5%, emulsifier 1.2-5%, grease 5-23%, thickener 2-8%, three ethyl alcohol
Amine 0.1-2%, 1,2- pentanediol 1-3%, surplus is deionized water.
Further, the emulsifier includes cetostearyl alcohol olive oleate and cetanol palmitate, it is preferable that institute
It includes cetostearyl alcohol olive oleate 1-3% and cetanol palmitate 0.2-2% to state emulsifier.
Further, the grease is selected from SIMMONDSIA CHINENSIS SEED OIL, isononyl isononanoate, dimethiconol, ring five poly- two
It is one or more in methylsiloxane/Dimethicone Crosspolymer, isomery hexadecane.Preferably, the grease
Including SIMMONDSIA CHINENSIS SEED OIL 1-5%, isononyl isononanoate 1-5%, dimethiconol 1-5%, ring five dimethyl silicone polymer/
Dimethicone Crosspolymer 1-5%, isomery hexadecane 1-3%.
Further, the thickener includes acrylic acid (ester) analog copolymer, lecithin, acrylic acid (ester) class/isodecyl acid
It is one or more in vinyl acetate cross-linked polymer, glycerine polyacrylate.Preferably, the thickener includes acrylic acid (ester)
Analog copolymer 0.6-1%, lecithin 0.4-1%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer 0.1-1%, glycerine
Polyacrylate 1-5%.
The fourth aspect of the present invention provides the preparation method of above-mentioned whitening cosmetics, which is creams,
Described method includes following steps：
(1) each raw material for standby is weighed by weight percentage；
(2) emulsifier, grease, acrylic acid (ester) analog copolymer, lecithin are sequentially added into oil phase pot, under stirring condition,
Warming-in-water is to keeping the temperature 15-20min after 85 DEG C；
(3) by acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer, glycerine polyacrylate, triethanolamine, go from
Sub- water sequentially adds water phase pot, and under stirring condition, warming-in-water is to keeping the temperature 15-20min after 85 DEG C；
(4) homogenizer, at a temperature of 60 DEG C, 8000-12000rpm homogeneous is added in the material of oil phase pot and water phase pot
5-30min, until forming uniform emulsified body, temperature is down to 40 DEG C or less；
(5) at a temperature of 25-40 DEG C, mixing glycerine, functional component, 1,2- pentanediols, and stir to after dissolving and be added
Into the system of step (4), continue homogeneous 10-15min, after observation material body is uniform, is transferred to blender and stirs 10-15min, it is cold
But it can discharge to room temperature.
The effect of each component of the present invention, is as follows：
Gotu Kola P.E：From samphire centella, modern research shows that the product that Gotu Kola P.E contains
Oxalic acid and brahmic acid are avenged, has certain inhibiting effect to Pseudomonas aeruginosa, staphylococcus aureus, Propiobacterium etc.；
The generation of proinflammatory medium can be reduced, improve and repairs skin itself barrier function, to prevent and correct skin immune function
It is disorderly；Facilitation with fibroblast and collagen synthesis；Also there is stronger antioxidation, can inhibit freedom
Base activity, desalination melanin pigmentation improve skin blood circulation, update skin cell regeneration, and melanin is helped smoothly to be metabolized out
In vitro, beautiful using the smooth delicacy of rear skin, whitening.
Matrixyl -20：Inhibiting expression of tyrosinase gene reduces tyrosinase content；By reducing melanotropin
α-MSH and melanotropin precursor POMC inhibit melanocyte activation, reduce melanin production；Inhibit interleukins
The gene expression of interleukin-6 and interleukin-8 reduces pigmentation after inflammation.
Saccharomycete lysis object extract：By various natural components such as amino acid, polypeptide, minerals composition.It is imitated with moisturizing
Fruit can increase the absorption of the nascent protein confrontation moisture in Skin Cell, promote utilization of the skin to oxygen, to keep skin rich
It is full；With hyaluronic acid synthesis is promoted, promote the synthesis of elastin laminin and collagen, inhibit free radical, increases that cell is aerobic exhales
It inhales, releive, promote wound healing and other effects；To the inhibition of tyrosinase, inhibits melanin to be formed, promote the new old of skin
Metabolism, to achieve the effect that brilliant white skin.
Ceramide -3：Skin it is natural it is pure ingredient, play an important role to maintenance skin barrier；Angling can be remarkably reinforced
Adhesion strength between cell improves skin dryness, reduces desquamation of skin phenomenon；With hydrone ability of associating by force very much, pass through
Reticular structure is formed in cuticula maintains moisture of skin.
Glycerine：With dispersion, moisture-keeping function.
Emulsifier：Emulsification system is formed, makes each stable components, be uniformly dispersed wherein.
Grease：With water lock moisturizing, Palmitoleic Acid, the effect for protecting skin.
Thickener：With thickening, improve skin sense effect.
Triethanolamine：PH adjusting agent is used for the acid-base value of regulation system.
1,2- pentanediols：Natural polyalcohol is extracted from sugarcane and corn and is obtained.With antisepsis, avoid
Various adverse reactions caused by using traditional preservatives.
The invention has the advantages that：
The present invention has carried out a large amount of research to the extraction process of silk cocoon, and obtained silk-extract is to be distributed wide, molecule
Suitable protein combination is measured, based on the silk-extract, compounding Gotu Kola P.E, Matrixyl -20, saccharomycete are molten
The effect of born of the same parents' object extract and ceramide -3 ingredient, in the common of emulsifier, moisturizer, thickener, grease and pH adjusting agent
Under effect, synergistic function is played between each raw material, creams whitening spot-removing ability obtained is strong, while also having property temperature
With irritation it is small, moisten the advantages that degree is high, easily absorb, safe without toxic side effect.
Description of the drawings
Fig. 1 is the SDS-PAGE collection of illustrative plates for the silk-extract that the extraction process of number 1-11 in the embodiment of the present invention 1 obtains.
Fig. 2 is that subject's face spot change rate of experimental group and control group changes with time relationship comparison diagram.
Fig. 3 is that the ultraviolet spot change rate of subject's face of experimental group and control group changes with time relational graph.
Fig. 4 is that subject's part spot chloasma change rate of experimental group and control group changes with time relational graph.
Fig. 5 is that subject's changes in faces rate of experimental group and control group changes with time relational graph.
Fig. 6 is that subject's face melanin change rate of experimental group and control group changes with time relational graph.
Fig. 7 is that subject's changes in faces rate of experimental group and control group changes with time relational graph.
Fig. 8 is the chloasma that a certain subject is shown using 0 week rear face of creams of the embodiment of the present invention 4.
Fig. 9 is the chloasma that a certain subject is shown using 4 weeks rear faces of creams of the embodiment of the present invention 4.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
In addition to silk-extract, other reagents used in the present invention can be commercially available by commercial sources, wherein silkworm
Cocoon is practical kind, is bought from sericulture research institute of Chongqing City.
Embodiment 1
The present invention carries out following tests to silk extraction process：
Number 1：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, and papain is added, and the end of acquired solution is dense
Degree is 3g/L, and 60 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 2：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, and papain is added, and the end of acquired solution is dense
Degree is 2g/L, and 60 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 3：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, 0.1MPa, and 120 DEG C of processing 120min are filtered,
Filtrate is freeze-dried to obtain silk-extract.
Number 4：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, 0.1MPa, and 120 DEG C of processing 60min are filtered, filter
Liquid is freeze-dried to obtain silk-extract.
Number 5：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, 0.1MPa, and 120 DEG C of processing 30min are filtered, filter
Liquid is freeze-dried to obtain silk-extract.
Number 6：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, are added neutral soap, acquired solution it is final concentration of
2g/L, 100 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 7：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, are added sodium carbonate, acquired solution it is final concentration of
2g/L, 100 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 8：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, are added malic acid, acquired solution it is final concentration of
11g/L, 100 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 9：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, and papain is added, and the end of acquired solution is dense
Degree is 2.5g/L, and 60 DEG C of processing 60min, filtering, filtrate is freeze-dried to obtain silk-extract.
Number 10：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, are put into ultrasonic cleaning instrument, handle 60min, mistake
Filter, filtrate is freeze-dried to obtain silk-extract.
Number 11：Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, fiber is put under normal temperature condition discongests instrument and stir
60min is mixed, is filtered, filtrate is freeze-dried to obtain silk-extract.
The degumming rate and albumen concentration of the obtained silk-extracts of number 1-11 are calculated, representational result
It is shown in Table 1.
Table 1
The SDS-PAGE collection of illustrative plates for the silk-extract that the extraction process respectively numbered above obtains is shown in Fig. 1.
The result shows that：Most of method is not only of high cost, and the protein concentration extracted is low, molecular weight is big, or hydrolyzed
For only specific protein, effect is single, and has the problem of acid-base value differs, and needs post-processing.As the high temperature high pressure process time increases
Long, silk-extract protein molecular weight effectively reduces, and the smaller protein amounts of molecular weight increase, can obtain distribution it is wide,
The suitable protein combination of molecular weight, the extraction process can extract sericin and keep its activity, acquired silkworm to greatest extent
Silk extract, which has, to be inhibited tyrosinase activity, and is reduced melanin and is generated, and anti-oxidant, antiultraviolet protects skin, reduces skin
The characteristic of synthesis of melanin.
Embodiment 2
A kind of whitening spot-removing creams, by weight percentage, including the following raw material：Silk-extract 11%, centella extraction
Object 0.6%, Matrixyl -20 0.2%, saccharomycete lysis object extract 2.6%, ceramide -3 0.6%, glycerine 3%,
Cetostearyl alcohol olive oleate 2.2%, SIMMONDSIA CHINENSIS SEED OIL 1%, isononyl isononanoate 1%, gathers cetanol palmitate 1.8%
Dimethyl silica alkanol 1%, ring five dimethyl silicone polymer/Dimethicone Crosspolymer 1%, isomery hexadecane
1%, acrylic acid (ester) analog copolymer 0.6%, lecithin 0.6%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer
0.8%, glycerine polyacrylate 4%, triethanolamine 0.6%, 1,2- pentanediols 1%, surplus are deionized water.
Wherein, silk-extract is made as follows：
Silk cocoon is after over cleaning infiltrates, with 1:40 bath raioes enter water, and 2h is handled under conditions of 0.1MPa, 120 DEG C, filtering,
After filtrate is freeze-dried, silk-extract is obtained.
The preparation method of above-mentioned whitening spot-removing creams, includes the following steps：
(1) each raw material for standby is weighed by weight percentage；
(2) emulsifier, grease, acrylic acid (ester) analog copolymer, lecithin are sequentially added into oil phase pot, under stirring condition,
Warming-in-water is to keeping the temperature 15min after 85 DEG C；
(3) by acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer, glycerine polyacrylate, triethanolamine, go from
Sub- water sequentially adds water phase pot, and under stirring condition, warming-in-water is to keeping the temperature 20min after 85 DEG C；
(4) homogenizer, at a temperature of 60 DEG C, 8000-12000rpm homogeneous is added in the material of oil phase pot and water phase pot
15min, until forming uniform emulsified body, temperature is down to 40 DEG C or less；
(5) at a temperature of 35 DEG C, mixing glycerine, functional component, 1,2- pentanediols, and stir and be added to step to after dissolving
Suddenly in the system of (4), continue homogeneous 15min, after observation material body is uniform, is transferred to blender stirring 10min, is cooled to room temperature i.e.
It can discharge.
Embodiment 3
A kind of whitening spot-removing creams, by weight percentage, including the following raw material：Silk-extract 6%, Gotu Kola P.E
0.2%, Matrixyl -20 0.5%, saccharomycete lysis object extract 0.2%, ceramide -3 0.2%, glycerine 5%, whale
Wax stearyl alcohol olive oleate 1.5%, SIMMONDSIA CHINENSIS SEED OIL 3.5%, isononyl isononanoate 1%, gathers cetanol palmitate 1.5%
Dimethyl silica alkanol 3%, ring five dimethyl silicone polymer/Dimethicone Crosspolymer 2.5%, isomery hexadecane
2%, acrylic acid (ester) analog copolymer 1%, lecithin 1%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer 1%, sweet
Oily polyacrylate 5%, triethanolamine 1.5%, 1,2- pentanediols 3%, surplus are deionized water.
Wherein, silk-extract is made as follows：
Silk cocoon is after over cleaning infiltrates, with 1:60 bath raioes enter water, and 3h is handled under conditions of 0.15MPa, 110 DEG C, filtering,
After filtrate is freeze-dried, silk-extract is obtained.
The preparation method of the whitening spot-removing creams of the present embodiment is the same as embodiment 2.
Embodiment 4
A kind of whitening spot-removing creams, by weight percentage, including the following raw material：Silk-extract 17%, centella extraction
Object 1%, Matrixyl -20 2%, saccharomycete lysis object extract 1.5%, ceramide -3 1.5%, glycerine 1%, spermaceti
Stearyl alcohol olive oleate 0.7%, cetanol palmitate 0.8%, SIMMONDSIA CHINENSIS SEED OIL 5%, isononyl isononanoate 5%, poly- diformazan
Radical siloxane alcohol 4.5%, ring five dimethyl silicone polymer/Dimethicone Crosspolymer 4.5%, isomery hexadecane
2.6%, acrylic acid (ester) analog copolymer 0.6%, lecithin 0.4%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer
1%, glycerine polyacrylate 1%, triethanolamine 0.1%, 1,2- pentanediols 2%, surplus are deionized water.
Wherein, silk-extract is made as follows：
Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, and 2h is handled under conditions of 0.1MPa, 130 DEG C, filtering,
After filtrate is freeze-dried, silk-extract is obtained.
The preparation method of the whitening spot-removing creams of the present embodiment is the same as embodiment 2.
Embodiment 5
A kind of whitening spot-removing creams, by weight percentage, including the following raw material：Silk-extract 17.5%, centella carry
Take object 2%, Matrixyl -20 1.5%, saccharomycete lysis object extract 3%, ceramide -3 3%, glycerine 5%, spermaceti
Stearyl alcohol olive oleate 3%, cetanol palmitate 2%, SIMMONDSIA CHINENSIS SEED OIL 2%, isononyl isononanoate 2%, poly dimethyl silicon
Oxygen alkanol 3.7%, ring five dimethyl silicone polymer/Dimethicone Crosspolymer 1.2%, isomery hexadecane 1.2%,
It is acrylic acid (ester) analog copolymer 0.6%, lecithin 1%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer 0.4%, sweet
Oily polyacrylate 1%, triethanolamine 0.8%, 1,2- pentanediols 1.6%, surplus are deionized water.
Wherein, silk-extract is made as follows：
Silk cocoon is after over cleaning infiltrates, with 1:60 bath raioes enter water, and 2.5h, mistake are handled under conditions of 0.1MPa, 110 DEG C
Filter, after filtrate is freeze-dried, obtains silk-extract.
The preparation method of the whitening spot-removing creams of the present embodiment is the same as embodiment 2.
Embodiment 6
A kind of whitening spot-removing creams, by weight percentage, including the following raw material：Silk-extract 3%, Gotu Kola P.E
0.1%, Matrixyl -20 0.1%, saccharomycete lysis object extract 0.2%, ceramide -3 0.2%, glycerine 2%, whale
Wax stearyl alcohol olive oleate 1.5%, SIMMONDSIA CHINENSIS SEED OIL 3%, isononyl isononanoate 3.6%, gathers cetanol palmitate 0.5%
Dimethyl silica alkanol 4%, ring five dimethyl silicone polymer/Dimethicone Crosspolymer 3.7%, isomery hexadecane
2.4%, acrylic acid (ester) analog copolymer 0.8%, lecithin 1%, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer
0.2%, glycerine polyacrylate 3.4%, triethanolamine 1.8%, 1,2- pentanediols 2.5%, surplus are deionized water.
Wherein, silk-extract is made as follows：
Silk cocoon is after over cleaning infiltrates, with 1:50 bath raioes enter water, and 3h is handled under conditions of 0.15MPa, 120 DEG C, filtering,
After filtrate is freeze-dried, silk-extract is obtained.
The preparation method of the whitening spot-removing creams of the present embodiment is the same as embodiment 2.
Comparative example 1
The raw material components of the whitening spot-removing creams of this comparative example are same as Example 2, the difference is that only：This comparative example
Silk-extract is replaced with ursin.
The preparation method of the whitening spot-removing creams of this comparative example is the same as embodiment 2.
Comparative example 2
The raw material components of the whitening spot-removing creams of this comparative example are same as Example 2, the difference is that：This comparative example is adopted
The silk-extract sold with Kyushu University replaces the silk-extract in embodiment 2.
The preparation method of the whitening spot-removing creams of this comparative example is the same as embodiment 2.
Comparative example 3
The raw material components of the whitening spot-removing creams of this comparative example are same as Example 2, the difference is that：This comparative example
Silk-extract is made up of the extraction process of number 9 in embodiment 1.
The preparation method of the whitening spot-removing creams of this comparative example is the same as embodiment 2.
Test case
1, the sense organ and physical and chemical index of the whitening spot-removing creams of the present invention are tested
Appearance：Wiping materials in visual observations under temperature and non-direct sunlight indoors on skin.
Fragrance：It materialses, is differentiated with smell.
Heat-resisting cold-resistant indication test method：Outturn sample is respectively placed in 40 DEG C of constant incubator and -15 DEG C of refrigerator
In, it takes out afterwards restore whether have layering or apparent Traits change to room temperature observation sample for 24 hours.
Acid-base value test method：Using dilution method, it is 10% that sample, which is diluted to mass percent, with deionized water, uses pH
Meter is tested.
The organoleptic indicator of creams made from the embodiment of the present invention 2 and physical and chemical index test result are shown in Table 2.
Table 2
The organoleptic indicator of the creams of embodiment 3-6 and physical and chemical index test result and embodiment 2 are without significant difference.
The result shows that：The sense organ and physical and chemical index of the whitening spot-removing creams of the present invention meet China's moisturizing cream industry mark
The requirement of quasi- QB/T 1857-2013, product are stablized, and pH=5.5-7 is close with skin ph value, does not stimulate mildly.
2, sanitary microorganism inspection and health chemical testing are carried out to the whitening spot-removing creams of the present invention
The sanitary microorganism of creams made from the embodiment of the present invention 2 is examined and health chemical testing the results are shown in Table 3.
Table 3
The sanitary microorganism inspection of the creams of embodiment 3-6 and health chemical testing result and embodiment 2 are without significant difference.
The result shows that：The whitening spot-removing creams of the present invention meet《Cosmetics health specification》Regulation.
3, the safety and skin irritation of the whitening spot-removing creams of the present invention are tested
Test method 1：New zealand rabbit 20 (weight 1.5-2Kg) is chosen, the first 24 hours back ridges to every rabbit are tested
Column both sides carry out depilation processing, the left and right each 3cm × 3cm of unhairing range.Mode, the left backbone of every rabbit are compareed using skin auto
The creams about 3g of the embodiment of the present invention 2 is smeared in area, applies skin daily 1 time, and continuous 14 days, upper right spinal area did not made any processing conduct
Control.Situations such as daily observation applies skin and compares the erythema and oedema at position, the results are shown in Table 4.
Table 4
Above-mentioned skin irritation test is carried out respectively to the creams of embodiment 3-6, result is with embodiment 2 without significance difference
It is different.
The result shows that：The whitening spot-removing creams of the present invention belong to nonirritant to skin irritatin strength grading.
Test method 2：9 age in days Bai Laihang chickens fertilization SPF chicken embryos 30 are taken, experiment 1-5 groups, every group of 6 chicken embryos are divided into.
Eggshell surface marks gas chamber position, and the eggshell part of tape label is peelled off with the curved tweezer of dentistry sawtooth, white egg film is exposed, uses suction pipe
0.9% sodium chloride of 2mL (NaCl) solution, which is added dropwise, makes egg film infiltrate, and slurry sodium chloride solution pours out, and inner membrance is carefully removed with tweezers,
Ensure that tunica vasculose is not damaged.The creams of 0.3mL embodiment of the present invention 2-6 are taken correspondingly to directly act on experiment 1-5 groups respectively
Chicken embryo CAM films are gently rinsed with physiological saline after 3min.Observation experiment result after 30s.Its summation that scores reacts creams of the present invention
Potential eye irritation and corrosivity degree.It the results are shown in Table 5.
Table 5
The result shows that：Potential Eye irritation and the corrosivity classification of the whitening spot-removing creams of the present invention belong to nothing/subexcite.
(with reference to SN/T 2329-2009 cosmetics eye irritation/corrosive chick chorioallantoic membrane experiment)
Test method 3：0.025g/mL raw materials of the present invention (being diluted to 5% solution with olive oil or water) are taken respectively
And creams finished product made of embodiment 2-6 is put into spot examination device.Health volunteer 30 is randomly selected, by spot examination device with non-stimulated
Adhesive tape is affixed on the survey of subject's forearm song, is gently pressed with palm and is allowed to uniformly stick, continued for 24 hours.After removing spot examination device 30min, to skin
Skin adverse reaction is scored, is classified.It the results are shown in Table 6.
Table 6
The result shows that：The creams and its raw material of the present invention have no adverse reaction to human skin.(reference《Cosmetics
Hygienic practice (version in 2007)》)
4, evaluation experiment is carried out to the effect of whitening spot-removing creams of the present invention
Appraisal procedure one：The health volunteer between 240 ages 18-45 Sui is randomly selected, is grouped at random, is divided into
Test 1-5 groups, every group of 30 people compare 1-3 groups, every group of 30 people, and for every group of subject in gender, compare in terms of the age, difference is equal
Not statistically significant (P ＞ 0.05), is comparable.
The subject for testing 1-5 groups respectively smears creams made from 2 pump embodiment 2-6 after face cleaning daily morning and evening.
The subject for compareing 1-3 groups respectively smears creams made from 2 pump comparative example 1-3 after face cleaning daily morning and evening.
Skin detection is carried out using VISIA and MPA580 within 0th, 1,2,3,4 week, experimental data is counted with SPSS.
It the results are shown in Table 7.
Table 7
The result shows that：The subject of experimental group spot in the creams 28 days using the present invention is reduced；Ultraviolet spot, which has, to be subtracted
It is few；Chloasma is reduced；Black is known as fluctuation (speculating related with weather), and whole is still in substantially reduce trend.(*：p<0.05 has
Significant difference)
The subject of control group 1 spot in the creams 28 days using comparative example 1, which has, increases phenomenon, other are without significantly becoming
Change；Control group 2,3 subjects in the creams 28 days for using comparative example 2,3 respectively each index without significant changes.
Appraisal procedure 2：It chooses the health volunteer between 30 ages 18-45 Sui and carries out half face efficacy assessments, half face is surveyed
The error that examination can effectively reduce subject's medication, life pattern, hormonal change are brought.Subject takes after face cleaning daily morning and evening
Creams are applied to left face (experimental group) made from the 1 pump embodiment of the present invention 4, and creams made from 1 pump comparative example 2 is taken to be applied to right face conduct
It compares (control group).Skin detection is carried out using VISIA and MPA580 within 0th, 1,2,3,4 week, to experimental data Graphpad
Prism6 is counted.As a result see Fig. 2-Fig. 7.
The result shows that：In 4 weeks after use, the spot of subject's face of experimental group, ultraviolet spot, chloasma, red
Region, melanin, each index of haematochrome change rate increase slow than control group or decrease.Fig. 8 and Fig. 9 can be seen that certain
One subject using creams of the present invention after 4 weeks chloasma it is obviously thin out.
Above the experimental results showed that：The creams of the present invention can effectively reach whitening, spot-removal function.
5, the use feeling of the whitening spot-removing creams of the present invention is evaluated
It randomly selects 300 subjects, creams made from 2 pump embodiment of the present invention 2-6 is smeared after face cleaning 5min in face,
Questionnaire is filled in after 30min, and result is obtained through statistics.It the results are shown in Table 9.
Table 9
The result shows that：The quality of the whitening spot-removing creams of the present invention, sense of touch, trap, moistens degree by public good at gloss
It comments, meets the requirement of consumer.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.
Claims (10)
1. a kind of silk-extract, which is characterized in that the silk-extract is made of following steps：
Silk cocoon is after over cleaning infiltrates, with 1:40-60 bath raioes enter water, in 0.1-0.15MPa, 110-130 DEG C of processing 2-3h, mistake
Filter, after filtrate is freeze-dried, obtains silk-extract.
2. a kind of whitening spot-eliminating composition, which is characterized in that the whitening spot-eliminating composition includes silk described in claim 1
Extract, Gotu Kola P.E, Matrixyl -20, saccharomycete lysis object extract, ceramide -3.
3. whitening spot-eliminating composition according to claim 2, which is characterized in that in parts by weight, the whitening is dispelled
Spot composition includes silk-extract 2-20 parts described in claim 1,0.1-2 parts of Gotu Kola P.E, Matrixyl -20
0.1-2 parts, 0.1-3 parts of saccharomycete lysis object extract, -3 0.1-3 parts of ceramide.
4. a kind of whitening cosmetics, which is characterized in that using whitening spot-eliminating composition according to claim 2 or 3 as effect
Ingredient.
5. whitening cosmetics according to claim 4, which is characterized in that the whitening cosmetics include breast
Any one of frost, lotion, facial mask.
6. whitening cosmetics according to claim 5, which is characterized in that the whitening cosmetics are creams,
By weight percentage, including the following raw material：Functional component 2.4-30%, glycerine 1-5%, emulsifier 1.2-5%, grease 5-
23%, thickener 2-8%, triethanolamine 0.1-2%, 1,2- pentanediol 1-3%, surplus is deionized water.
7. whitening cosmetics according to claim 6, which is characterized in that the emulsifier includes cetostearyl alcohol olive
Olive oleate and cetanol palmitate.
8. whitening cosmetics according to claim 6, which is characterized in that the grease is selected from SIMMONDSIA CHINENSIS SEED OIL, different nonyl
The different nonyl ester of acid, dimethiconol, ring five dimethyl silicone polymer/Dimethicone Crosspolymer, isomery ten
It is one or more in six alkane.
9. whitening cosmetics according to claim 6, which is characterized in that the thickener includes acrylic acid (ester) class
Copolymer, lecithin, acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer, one kind in glycerine polyacrylate or more
Kind.
10. a kind of preparation method of the whitening cosmetics described in claim 9, described method includes following steps：
(1) each raw material for standby is weighed by weight percentage；
(2) emulsifier, grease, acrylic acid (ester) analog copolymer, lecithin are sequentially added into oil phase pot, under stirring condition, water-bath
15-20min is kept the temperature after being warming up to 85 DEG C；
(3) by acrylic acid (ester) class/isodecyl vinyl acetate cross-linked polymer, glycerine polyacrylate, triethanolamine, deionized water
Sequentially add water phase pot, under stirring condition, warming-in-water is to keeping the temperature 15-20min after 85 DEG C；
(4) homogenizer, at a temperature of 60 DEG C, 8000-12000rpm homogeneous 5- is added in the material of oil phase pot and water phase pot
30min, until forming uniform emulsified body, temperature is down to 40 DEG C or less；
(5) at a temperature of 25-40 DEG C, mixing glycerine, functional component, 1,2- pentanediols, and stir and be added to step to after dissolving
Suddenly in the system of (4), continue homogeneous 10-15min, after observation material body is uniform, is transferred to blender stirring 10-15min, is cooled to
Room temperature can discharge.
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| CN201810422200.4A CN108392434A (en) | 2018-05-04 | 2018-05-04 | A kind of silk-extract and whitening spot-eliminating composition and preparation method containing it |
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| CN109330968A (en) * | 2018-11-15 | 2019-02-15 | 广州博科化妆品有限公司 | A kind of sleep mask and preparation method thereof with tax regeneration function living |
| CN110664698A (en) * | 2019-11-21 | 2020-01-10 | 樊瑞 | Composition with whitening effect and preparation method thereof |
| CN110840793A (en) * | 2019-12-06 | 2020-02-28 | 广州微肽生物科技有限公司 | Fibroin mask liquid and preparation method thereof |
| CN113893216A (en) * | 2021-10-14 | 2022-01-07 | 安徽中美生谷生物科技有限公司 | Composition with whitening effect and preparation method thereof |
| CN115813774A (en) * | 2022-12-08 | 2023-03-21 | 麦吉丽生物科技有限公司 | Water-oil double-layer refined composition with whitening effect and preparation method and application thereof |
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| CN109330968A (en) * | 2018-11-15 | 2019-02-15 | 广州博科化妆品有限公司 | A kind of sleep mask and preparation method thereof with tax regeneration function living |
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| CN110840793A (en) * | 2019-12-06 | 2020-02-28 | 广州微肽生物科技有限公司 | Fibroin mask liquid and preparation method thereof |
| CN110840793B (en) * | 2019-12-06 | 2022-08-12 | 广州微肽生物科技有限公司 | Fibroin mask liquid and preparation method thereof |
| CN113893216A (en) * | 2021-10-14 | 2022-01-07 | 安徽中美生谷生物科技有限公司 | Composition with whitening effect and preparation method thereof |
| CN115813774A (en) * | 2022-12-08 | 2023-03-21 | 麦吉丽生物科技有限公司 | Water-oil double-layer refined composition with whitening effect and preparation method and application thereof |
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