CN108379124B - Essential oil for preventing and repairing skin barrier damage and preparation method and application thereof - Google Patents
Essential oil for preventing and repairing skin barrier damage and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses essential oil for preventing and repairing skin barrier damage, which comprises the following components in percentage by weight: 1.0-50% of camellia seed oil, 2.0-20% of vegetable oil, 0.5-5% of a soothing agent, 0.05-5% of a stabilizing agent and the balance of synthetic oil. The essential oil disclosed by the invention is rich in various functional components, and the components are mutually blended and have a synergistic effect, so that the essential oil can prevent the damage of a skin barrier and promote the repair process of the damage of the skin barrier, and has a good anti-allergy effect on sensitive skin with abnormal skin barrier function; in addition, the essential oil disclosed by the invention does not contain an emulsifier and an essence component, so that no extra burden is caused on the skin.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to essential oil for preventing and repairing skin barrier damage, and a preparation method and application thereof.
Background
With the improvement of living standard, people pay more attention to the skin care, especially the facial skin care. Maintaining normal barrier function of the skin is a fundamental and important component of skin care. The skin barrier structure and function are abnormal in different degrees due to internal and external factors such as hormone level fluctuation, mental stress, external stimulation, ultraviolet rays and environmental pollution, and even seriously, the skin barrier function is damaged, and the damage of the skin barrier function is one of important factors for causing various skin diseases. The thickness of the stratum corneum of the face is thin, and skin barrier abnormal conditions such as sensitivity, intolerance and the like easily occur to external stimulation, so that more attention needs to be paid to preventing the damage of the skin barrier function of the face, and measures are taken to recover the barrier function in time once the damage of the skin barrier occurs. The prior art reports the role of ceramide in skin barrier repair, but studies show that ceramide mainly plays a role in the later stage of skin barrier repair (Wu jin Yan, Jiangxu, ceramide and skin barrier, China J. dermatosis (J), 2011,25(1): 64-65.). Moreover, no reports on the prevention of skin barrier damage by using an efficacy substance have been found so far.
Camellia seed oil, also known as tea oil, camellia oil, tea seed oil and the like, is rich in nutrient substances such as unsaturated fatty acid, tea polyphenol, squalene, vitamin E, zinc and the like, has a nutritional value comparable to that of olive oil, and is called oriental olive oil and magical oriental oil. Camellia japonica is a unique woody oil tree species in southern areas of China and has a very long cultivation history. In view of the unique growth environment of camellia, the unique components and effects of woody oil, camellia oil has excellent cosmetic application value. Compared with the common high-grade oil of cosmetics, the camellia oil also has potential advantages in the aspects of skin feel, efficacy, safety and the like. The camellia seed oil, tea seed oil and camellia seed oil of the camellia genus are also very similar in components, efficacy and the like. At present, researches on camellia seed oil mainly focus on the aspects of food health care, moistening, antioxidation, whitening, aging resistance and the like, and the researches on the prevention and repair of skin barrier damage of the camellia seed oil are still in a blank stage.
Although some skin care products for repairing skin barrier damage exist on the market, in order to improve certain aspects of efficacy, ingredients such as preservatives, emulsifiers, essences, hormones and surfactants are usually added, and the ingredients can cause additional burden to the skin. CN105997625A discloses a moisturizing cream for daily care of children skin mucosa and application thereof, wherein the moisturizing cream contains a surfactant APG and a preservative lysozyme or antimicrobial peptide, and causes unnecessary burden on the skin. Therefore, it is necessary to develop an essential oil for preventing and repairing skin barrier damage and relieving skin sensitivity without adding components such as emulsifiers, essence components and the like.
Disclosure of Invention
In view of the defects of the prior art, the invention aims to provide the essential oil for preventing and repairing skin barrier damage. The essential oil disclosed by the invention is rich in various functional components, and the components are mutually blended and have a synergistic effect, so that the essential oil can prevent the damage of a skin barrier and promote the repair process of the damage of the skin barrier, and has a good anti-allergy effect on sensitive skin with abnormal skin barrier function. In addition, the essential oil disclosed by the invention does not contain an emulsifier and an essence component, and does not generate additional burden on the skin.
The technical scheme adopted by the invention is as follows: the essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 1.0-50% of camellia seed oil, 2.0-20% of vegetable oil, 0.5-5% of a soothing agent, 0.05-5% of a stabilizing agent and the balance of synthetic oil. More preferably, the essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 5-40% of camellia seed oil, 5-15% of vegetable oil, 1-5% of a soothing agent, 0.1-4% of a stabilizing agent and the balance of synthetic oil; further preferably, the essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 10-30% of camellia seed oil, 8-12% of vegetable oil, 2-4% of a soothing agent, 1-3% of a stabilizing agent and the balance of synthetic oil.
Preferably, the camellia seed oil is selected from one or more of camellia seed oil, camellia seed oil and tea seed oil.
Preferably, the vegetable oil and fat is selected from one or more of wheat germ oil, sea buckthorn fruit oil, olive fruit oil, almond oil, prinsepia utilis royle oil, sweet almond oil, bitter orange flower oil, sweet orange peel oil, jojoba seed oil, maorezu fruit oil, avocado oil, wild soybean oil and macadamia nut seed oil.
Preferably, the soothing agent is selected from one or more of defensel, chamomile extract, calendula extract, bisabolol, asiaticoside, indomethacin and licoflavone.
Preferably, the stabilizer is selected from one or more of tocopheryl acetate, rosemary extract, BHT, ethylhexyl methoxycinnamate, benzotriazolyl dodecyl p-cresol, methylene bis-benzotriazolyl tetramethyl butyl phenol and coenzyme Q10.
Preferably, the synthetic oil or fat is selected from one or more of ethylhexyl palmitate, coco-caprylate/caprate, hydrogenated olive oil sebacate, dioctyl carbonate, squalane, ceramide and glyceryl caprylate/caprate.
The invention also provides a preparation method of the essential oil for preventing and repairing skin barrier damage, which comprises the following steps:
1) adding synthetic grease and a stabilizer into a reactor, heating to 55-60 ℃, and stirring and mixing;
2) cooling to 40-45 ℃, adding vegetable oil and stirring;
3) cooling to room temperature, sequentially adding camellia seed oil and a soothing agent, stirring, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Preferably, in the step 1), the rotation speed of stirring and mixing is 200-300rpm, and the stirring time is 3-5 min; in the step 2), the rotation speed of stirring and mixing is 200-300rpm, and the stirring time is 5-10 min; in the step 3), the rotation speed of stirring and mixing is 200-300rpm, and the stirring time is 5-10 min.
More specifically, the preparation method of the essential oil for preventing and repairing skin barrier damage comprises the following steps: adding synthetic oil and a stabilizer into a reactor under stirring at a rotating speed of 200-300rpm, heating to 55-60 ℃, stirring and mixing for 3-5min, cooling to 40-45 ℃, adding vegetable oil, stirring uniformly for 5-10min, continuously cooling to room temperature, sequentially adding camellia seed oil and a soothing agent, stirring and mixing at a rotating speed of 200-300rpm for 5-10min, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
The invention also provides application of the essential oil for preventing and repairing skin barrier damage in cosmetics for preventing and repairing skin barrier damage.
More preferably, the essential oil for preventing and repairing skin barrier damage can be applied to sensitive skin with abnormal skin barrier function, and used as anti-allergy cosmetics.
The invention also provides application of the essential oil for preventing and repairing skin barrier damage in cosmetics for people with weak skin barrier function.
More preferably, the essential oil for preventing and repairing skin barrier damage can be applied to infant skin care products or cosmetics.
The invention has the beneficial effects that: the essential oil disclosed by the invention is rich in various functional components, and the camellia seed oil contains tea polyphenol, monounsaturated fatty glyceride, phytosterol and saponin components, and has the effects of resisting inflammation, relieving, supplementing skin lipid and promoting skin barrier recovery; the vegetable oil and fat can supplement skin lipid, restore skin water and oil balance and enhance skin barrier; soothing agents can improve the sensitive conditions caused by barrier damage; the stabilizer enhances the antioxidation and ultraviolet absorption of the skin, helps the skin to resist the damage of harmful factors such as ultraviolet and the like, and simultaneously improves the stability of the product to the light and heat; the synthetic oil forms a protective film on the skin surface. The components are mutually blended and have synergistic effect, so that the skin barrier repairing liquid can prevent the damage of the skin barrier and promote the repairing process of the damage of the skin barrier, and has good anti-allergy effect on sensitive skin with abnormal skin barrier function; in addition, the essential oil disclosed by the invention does not contain an emulsifier and an essence component, so that no extra burden is caused on the skin.
Detailed Description
The present invention is further illustrated by the following specific examples, which are intended to be illustrative only and not limiting.
Example 1
The essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 5% of camellia seed oil, 14% of vegetable oil, 1.15% of a soothing agent, 2.45% of a stabilizing agent and 77.4% of synthetic oil.
Wherein the Camellia seed oil is selected from Camellia seed oil; the vegetable oil is selected from almond oil, wheat germ oil and palm fruit oil; the soothing agent is selected from defensel and phentermine; the stabilizer is selected from BHT, tocopherol acetate and ethylhexyl methoxycinnamate; the synthetic oil and fat is ethylhexyl palmitate.
The preparation method of the essential oil for preventing and repairing skin barrier damage comprises the following steps: adding 77.4% of ethylhexyl palmitate, 0.05% of BHT, 2.0% of tocopheryl acetate and 0.4% of ethylhexyl methoxycinnamate into a reactor under stirring at the rotating speed of 200rpm, heating to 55 ℃, stirring and mixing for 3min, cooling to 40 ℃, adding 6.0% of almond oil, 6.0% of wheat germ oil and 2.0% of Daphnia giraldii fruit oil, uniformly stirring for 5min, continuously cooling to room temperature, sequentially adding 5.0% of camellia oil, 1.0% of defenseil and 0.15% of chlorphenamine, stirring and mixing for 5min at the rotating speed of 300rpm, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Example 2
The essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 1% of camellia seed oil, 12% of vegetable oil, 0.5% of a soothing agent, 4.6% of a stabilizing agent and 81.9% of synthetic oil.
Wherein the Camellia seed oil is selected from Camellia seed oil; the vegetable oil is selected from olive oil, prinsepia utilis royle oil, and sea buckthorn oil; the soothing agent is selected from bisabolol; the stabilizer is selected from BHT, tocopherol acetate and benzotriazolyl dodecyl p-cresol; the synthetic oil and fat is ethylhexyl palmitate.
Adding 81.9% ethylhexyl palmitate, 0.1% BHT, 4.0% tocopheryl acetate and 0.5% benzotriazole dodecyl p-cresol into a reactor under stirring at the rotating speed of 300rpm, heating to 60 ℃, stirring and mixing for 5min, cooling to 45 ℃, adding 6.0% olive oil, 5.0% prinsepia utilis royle oil and 1.0% seabuckthorn fruit oil, stirring uniformly for 10min, continuously cooling to room temperature, sequentially adding 1% camellia oleifera seed oil and 0.5% bisabolol, stirring and mixing for 10min at the rotating speed of 200rpm, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Example 3
The essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 10% of camellia seed oil, 14% of vegetable oil, 2% of a soothing agent, 4.7% of a stabilizing agent and 69.3% of synthetic oil.
Wherein the Camellia seed oil is selected from tea seed oil; the vegetable oil is selected from olive oil, bitter orange flower oil, sweet orange peel oil, jojoba oil and sweet almond oil; the soothing agent is selected from the group consisting of chamomile flower extract and calendula extract; the stabilizer is selected from BHT, tocopherol acetate and ethylhexyl methoxycinnamate; the synthetic oil and fat is selected from ethylhexyl palmitate and coco caprylate/caprate.
Adding 39% of ethylhexyl palmitate, 30.3% of coconut oil alcohol-caprylate/caprate, 0.1% of BHT, 4.0% of tocopherol acetate and 0.6% of ethylhexyl methoxycinnamate into a reactor under the stirring of a rotating speed of 250rpm, heating to 55 ℃, stirring and mixing for 5min, cooling to 45 ℃, adding 6.0% of olive oil, 4.0% of bitter orange flower oil, 2.0% of sweet orange peel oil, 1.0% of jojoba seed oil and 1.0% of sweet almond oil, stirring uniformly for 10min, continuously cooling to room temperature, sequentially adding 10% of tea seed oil, 1% of chamomile extract and 1% of calendula extract, stirring and mixing for 5min at a rotating speed of 250rpm, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Example 4
The essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 50% of camellia seed oil, 10% of vegetable oil, 1.15% of a soothing agent, 0.38% of a stabilizing agent and 38.47% of synthetic oil.
Wherein the Camellia seed oil is selected from tea seed oil; the vegetable oil and fat is selected from olive oil, wild soybean oil, avocado oil and macadamia nut oil; the soothing agent is selected from licoflavone and phenix; the stabilizer is selected from BHT and ethylhexyl methoxycinnamate; the synthetic oil is selected from hydrogenated olive oil decanol esters, dioctyl carbonate, ceramide and squalane.
Adding 31% hydrogenated olive oil decanol esters, 5% dioctyl carbonate, 2% squalane, 0.47% ceramide, 0.3% ethylhexyl methoxycinnamate and 0.08% BHT into a reactor under the stirring of 250rpm, heating to 55 ℃, stirring and mixing for 5min, cooling to 45 ℃, adding 6.0% olive oil, 2.0% wild soybean oil, 1.0% avocado oil and 1.0% macadamia nut seed oil, stirring uniformly for 5min, continuously cooling to room temperature, sequentially adding 50% tea seed oil, 1% licoflavone and 0.15% euphorbia mollifolia, stirring and mixing for 10min at 300rpm, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Example 5
The essential oil for preventing and repairing skin barrier damage comprises the following components in percentage by weight: 20% of camellia seed oil, 8% of vegetable oil, 1.15% of a soothing agent, 0.43% of a stabilizing agent and 70.42% of synthetic oil.
Wherein the Camellia seed oil is selected from tea seed oil and camellia seed oil; the vegetable oil is selected from olive oil, prinsepia utilis royle oil and wheat germ oil; the soothing agent is selected from asiaticoside and phentermine; the stabilizer is selected from coenzyme Q10 and herba Rosmarini officinalis extract; the synthetic oil is selected from hydrogenated olive oil decanol esters, dioctyl carbonate and squalane.
Adding 32% hydrogenated olive oil decanol esters, 34% dioctyl carbonate, 4.42% squalane, 0.3% coenzyme Q10 and 0.13% rosemary extract into a reactor under the stirring of 300rpm, heating to 60 ℃, stirring and mixing for 3min, cooling to 45 ℃, adding 6.0% olive oil, 1.0% prinsepia utilis royle oil and 1.0% wheat germ oil, stirring uniformly for 5min, continuously cooling to room temperature, sequentially adding 10% tea seed oil, 10% camellia seed oil, 1% asiaticoside and 0.15% indomethacin, stirring and mixing for 5min at 300rpm, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
Comparative example 1
Adding 82.4% ethylhexyl palmitate, 0.05% BHT, 2.0% tocopheryl acetate and 0.4% ethylhexyl methoxycinnamate into a reactor under stirring at the rotating speed of 200rpm, heating to 55 ℃, stirring and mixing for 3min, cooling to 40 ℃, adding 6.0% almond oil, 6.0% wheat germ oil and 2.0% sorrel fruit oil, stirring uniformly for 5min, continuously cooling to room temperature, sequentially adding 1.0% defenseil and 0.15% chlorpheniramine, stirring and mixing for 5min at the rotating speed of 300rpm, and filtering to obtain a control sample without camellia seed oil.
Test example 1 evaluation of protective Barrier Damage prevention and repair Effect
1. Evaluation method
The control samples of examples 1-5, comparative example 1 without camellia oil and the pure camellia oil samples were used for the tests. The test is completed by 10 qualified volunteers. Volunteers were between 23 and 41 years of age, with a mean age of 30.2 ± 5.94 years. During the trial, the subjects did not develop erythema, papules, wheal, itching, and other adverse skin reactions associated with the trial samples.
After the skin is adapted in a room with constant temperature (22 +/-1 ℃) and constant humidity (50 +/-5%) for 30 minutes, the moisture content of the horny layer and the percutaneous water loss rate (TEW L) of the skin are firstly tested, and samples are added according to the ratio of (2.0 +/-0.1) mg/cm2The amount was applied to the inner forearm (4cm × 4cm) and the inner right forearm (4cm × 4cm) of the volunteer, after massage until absorption, the parts were peeled off 15 times with a tape to cause skin barrier damage, the stratum corneum moisture content and the percutaneous water loss rate (TEW L) of the skin were tested before application of the sample, 1 hour, 2 hours, and 4 hours after tape peeling, respectively, blank control (no sample applied but also peeled off with tape) was tested simultaneously.
2. Evaluation results
(1) The evaluation results are expressed as the average value of the water content of the horny layer and are shown in Table 1.
Table 1 essential oils of examples 1-5 and comparative example 1 essential oil, camellia seed oil, and blank control
Water content of stratum corneum at different times%
| Sample (I) | 0h | 1h | 2h | 4h |
| EXAMPLE 1 essential oils | 19.7±8.8 | 41.5±10.7 | 40.8±9.5 | 40.5±9.4 |
| EXAMPLE 2 essential oils | 19.3±6.6 | 38.7±8.9 | 36.3±8.7 | 35.4±8.6 |
| EXAMPLE 3 essential oils | 18.6±7.8 | 39.5±9.5 | 37.3±10.5 | 36.3±12.8 |
| EXAMPLE 4 essential oils | 18.9±9.3 | 40.7±12.6 | 39.5±9.4 | 38.2±7.3 |
| Practice ofEXAMPLE 5 essential oil | 18.2±8.7 | 41.1±10.4 | 38.1±11.3 | 37.6±9.5 |
| Comparative example 1 sample | 18.4±7.2 | 37.2±11.7 | 38.8±14.6 | 40.1±15.9 |
| Camellia seed oil | 19.2±9.7 | 33.4±9.4 | 32.3±10.2 | 31.1±10.6 |
| Blank control | 19.7±7.3 | 25.4±7.5 | 23.3±7.6 | 22.2±8.8 |
The results of comparing the essence oil in example 1, the sample in comparative example 1 and the camellia oil show that, for the improvement effect of the moisture content of the skin stratum corneum, the essence oil in example 1, the sample in comparative example 1 and the camellia oil > blank control, the results show that the synthetic oil ethylhexyl palmitate is replaced by the camellia oil on the basis of example 1, the moisture content of the stratum corneum is reduced, and the synergistic effect of the essence oil obtained by compounding the camellia oil on the prevention and repair of the skin barrier damage is realized. The results in Table 1 show that the essential oils of examples 2 to 5 also have the effect of preventing and repairing skin barrier damage.
(2) The evaluation results were expressed as the average value of the percutaneous water loss rate (TEW L), and the results are shown in Table 2.
Table 2 essential oils of examples 1-5 and comparative example 1 essential oil, camellia seed oil, and blank control
TEW L/% of the percutaneous water loss rate at different times
It is known that in various skin having a problem of impaired skin barrier function (for example, atopic dermatitis, contact dermatitis, etc.), water loss from the skin is more vigorous than that of healthy skin.
The results of comparing the essence oil in example 1, the sample in comparative example 1 and the camellia oil show that, for the reduction effect of the transdermal water loss rate (TEW L), the essence oil in example 1 > the sample in comparative example 1 > the camellia oil > blank control, the results show that the camellia oil is replaced by the synthetic oil ethylhexyl palmitate on the basis of example 1, the transdermal water loss rate (TEW L) is increased, and the essence oil obtained by compounding the camellia oil has a synergistic effect on the prevention and repair of the skin barrier damage, and the results in Table 2 show that the essence oils in examples 2 to 5 also have the effects of preventing and repairing the skin barrier damage.
According to the evaluation results, the essential oil disclosed by the invention is rich in various functional components, and the components are mutually blended and have a synergistic effect, so that the essential oil can prevent the damage of the skin barrier and promote the repair process of the damage of the skin barrier, and has a good anti-allergy effect on sensitive skin with abnormal skin barrier function.
Test example 2 evaluation of soothing anti-allergy Effect
20 volunteers with sensitive skin were selected, first using the essential oils prepared according to examples 1-5 of the present invention, and then filled in the efficacy questionnaire and described the feeling of use. The average result shows that 90% of volunteers think that the skin is dry and tight and the skin is obviously relieved, 85% of volunteers think that the skin is relaxed, and 95% of volunteers think that the skin becomes smooth and moist after the skin is used. All volunteers did not show any side effects or allergic phenomena. Therefore, the essential oil has better relieving and anti-allergy performance.
Claims (8)
1. The essential oil for preventing and repairing skin barrier damage is characterized by comprising the following components in percentage by weight: 1.0-50% of camellia seed oil, 2.0-20% of vegetable oil, 0.5-5% of a soothing agent, 0.05-5% of a stabilizing agent and the balance of synthetic oil;
the camellia seed oil is selected from camellia seed oil; the synthetic oil and fat is selected from ethylhexyl palmitate.
2. A essential oil for preventing and repairing skin barrier damage according to claim 1, wherein the vegetable oil is selected from one or more of wheat germ oil, seabuckthorn fruit oil, olive fruit oil, almond oil, prinsepia utilis royle oil, sweet almond oil, bitter orange flower oil, sweet orange peel oil, jojoba seed oil, maoreur fruit oil, avocado oil, wild soybean oil and macadamia nut seed oil.
3. The essential oil for preventing and repairing skin barrier damage according to claim 1, wherein the soothing agent is selected from one or more of defensel, chamomile extract, calendula extract, bisabolol, asiaticoside, indomethacin and licoflavone.
4. The essential oil for preventing and repairing skin barrier damage according to claim 1, wherein the stabilizer is selected from one or more of tocopheryl acetate, rosemary extract, BHT, ethylhexyl methoxycinnamate, benzotriazolyl dodecyl p-cresol, methylene bis-benzotriazolyl tetramethylbutyl phenol, and coenzyme Q10.
5. The method for preparing essential oil for preventing and repairing skin barrier damage according to any one of claims 1 to 4, comprising the steps of:
1) adding synthetic grease and a stabilizer into a reactor, heating to 55-60 ℃, and stirring and mixing;
2) cooling to 40-45 ℃, adding vegetable oil and stirring;
3) cooling to room temperature, sequentially adding camellia seed oil and a soothing agent, stirring, and filtering to obtain the essential oil for preventing and repairing skin barrier damage.
6. Use of the essential oil for preventing and repairing skin barrier damage of any one of claims 1 to 4 in cosmetics for preventing and repairing skin barrier damage.
7. Use of the essential oil for preventing and repairing skin barrier damage according to any one of claims 1 to 4 in an anti-allergy cosmetic for sensitive skin with skin barrier dysfunction.
8. Use of essential oils for the prevention and repair of skin barrier damage according to any one of claims 1 to 4 in cosmetics for people with weak skin barrier function.
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| CN201810331060.XA CN108379124B (en) | 2018-04-13 | 2018-04-13 | Essential oil for preventing and repairing skin barrier damage and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000021373A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | DERMO-COSMETIC COMPOSITION FOR TOPICAL USE |
| IT202000021367A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | COMPOSITION BASED ON VITAMIN E FOR TOPICAL USE |
| IT202000021370A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | DERMO-COSMETIC COMPOSITION FOR TOPICAL USE |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109305A (en) * | 2016-07-19 | 2016-11-16 | 上海清轩生物科技有限公司 | Moisturizing remediation composition containing Camellia oil and application thereof |
| CN107281040A (en) * | 2017-07-28 | 2017-10-24 | 广州科缇生物科技有限公司 | A kind of maintenance essential oils for being directed to sensitive flesh and preparation method thereof |
| CN107854353A (en) * | 2017-11-02 | 2018-03-30 | 广州市美晟美容化妆品有限公司 | A kind of camellia skin-protection Essence and its preparation technology |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326750A (en) * | 2015-11-25 | 2016-02-17 | 杨挺 | Special tea oil skincare lotion for pregnant women |
| CN105832615A (en) * | 2016-05-18 | 2016-08-10 | 广州丹奇日用化工厂有限公司 | Cleansing and removing two-in-one cleansing oil and preparation method thereof |
| CN106176444A (en) * | 2016-08-26 | 2016-12-07 | 天津天狮生物发展有限公司 | Skin nursing essential oils and preparation method thereof |
| CN107095804A (en) * | 2017-06-09 | 2017-08-29 | 中山大学附属第医院 | A kind of tea seed extraction oil skin cream and preparation method thereof |
-
2018
- 2018-04-13 CN CN201810331060.XA patent/CN108379124B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109305A (en) * | 2016-07-19 | 2016-11-16 | 上海清轩生物科技有限公司 | Moisturizing remediation composition containing Camellia oil and application thereof |
| CN107281040A (en) * | 2017-07-28 | 2017-10-24 | 广州科缇生物科技有限公司 | A kind of maintenance essential oils for being directed to sensitive flesh and preparation method thereof |
| CN107854353A (en) * | 2017-11-02 | 2018-03-30 | 广州市美晟美容化妆品有限公司 | A kind of camellia skin-protection Essence and its preparation technology |
Non-Patent Citations (1)
| Title |
|---|
| 化妆品级茶籽油功能性的应用研究;刘建才等;《第一届中国个人护理品及原料学术研讨会暨中国天然植物化妆品产业发展论坛》;20131121;21-26 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000021373A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | DERMO-COSMETIC COMPOSITION FOR TOPICAL USE |
| IT202000021367A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | COMPOSITION BASED ON VITAMIN E FOR TOPICAL USE |
| IT202000021370A1 (en) * | 2020-09-09 | 2022-03-09 | Sigla S R L | DERMO-COSMETIC COMPOSITION FOR TOPICAL USE |
| EP3967295A1 (en) * | 2020-09-09 | 2022-03-16 | Sigla S.r.l. | Dermato-cosmetic composition for topical use |
| EP3967294A1 (en) * | 2020-09-09 | 2022-03-16 | Sigla S.r.l. | Dermato-cosmetic composition for topical use |
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