CN109303746A - A kind of prebiotic compositions and its preparation method and application - Google Patents
A kind of prebiotic compositions and its preparation method and application Download PDFInfo
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- CN109303746A CN109303746A CN201811524633.7A CN201811524633A CN109303746A CN 109303746 A CN109303746 A CN 109303746A CN 201811524633 A CN201811524633 A CN 201811524633A CN 109303746 A CN109303746 A CN 109303746A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The present invention provides a kind of prebiotic compositions, the composition includes: saccharomycete/rice fermentation Product filtrate 45-65%, xylose 01 derivatives 5-21% and Gotu Kola P.E 20-40% by weight percent, and the sum of mass percent of each component is 100%.A kind of prebiotic compositions provided by the invention, each component synergistic effect, the microecological balance of common maintenance skin, restore and reinforce the ability of skin itself self-renewing and maintenance, enhance skin barrier, improve skin quality from the root, well solves that water oil is unbalance, the skin problems such as red and swollen, dark yellow, coarse, dry, skin can be made to become water Rinsing simultaneously to slide, it is compact full.
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of prebiotic compositions and its preparation method and application, and in particular to
It is a kind of to adjust skin Tiny ecosystem, moisturizing and nourishing, the prebiotic compositions for improving skin resistance and its preparation method and application.
Background technique
Skin is the natural barrier of mankind's body surface, and there is many microorganisms, skin microecological balance remains skin ring
The stabilization in border plays an important role to the health of body.
Under the conditions of normal colony balance, a large amount of beneficial bacteriums of skin surface play the effect for protecting skin health.
Probiotics is had the advantage, and change ring by own metabolism after the privileged site growth of skin surface in nutrient competition
The pH value or release antibiotic in border generate Ant agonism to other floras to inhibit the growth of harmful bacteria and foreign bacteria.
The skins excreta such as inorganic salts, uric acid and urea can also be absorbed and utilized in probiotics, and heavy metal ion pair is resisted on balance skin surface
The infringement of cell, water conservation moisturizing etc..
However the slight change of skin environment, excessive cleaning, using antibiotic, ultraviolet light, lack nutrition, cold etc. all
It can constitute a threat to probiotics, destroy the balance between probiotics and other bacteriums, cause flora imbalance.At this point, probiotics is reduced,
They will gradually be replaced by harmful bacteria, and skin environment changes, while also changing the environment of growth of probiotics, the number of probiotics
Amount will be further reduced, and skin food is sucked by harmful bacteria, and harmful bacteria is promoted further to breed, and generate pernicious circulation.
Skin is occupied by harmful bacteria, and first barrier is destroyed, if flora imbalance be not effectively controlled will cause it is some common
Skin disease, such as chloasma, psoriasis, atopic dermatitis, acne, redness, convulsion are itched, and the original brilliance of skin is lost.
As it can be seen that skin probiotics is for maintaining the integrality of skin texture and function to be very important.CN
105997593 A disclose a kind of unbalance prebiotic meta function formula for alleviating eczema of adjusting skin flora, and which disclose this
A kind of unbalance prebiotics formula for alleviating eczema of adjusting skin flora filtered out of disclosure of the invention, the formula active component group by
Chinese mugwort essential oil, inulin and alpha-glucans oligosaccharides are formed by different proportion, but are added to Chinese mugwort essential oil in that patent, cost compared with
It is high.103622901 A of CN discloses a kind of composition of skin cleanser for being adjustable skin microecological balance and its preparation side
Method ", which disclose a kind of composition of skin cleanser for being adjustable skin microecological balance.The composition of raw materials of the composition
Especially through the composition of addition oligosaccharide and probiotics metabolite, achieve the purpose that adjust skin microecological balance.But
In the patent, product composition is single, both effectiveness not strong.
As biotechnology is in molecular biology, the fast development of medicine and other fields, adjusts and maintenance skin Tiny ecosystem is flat
Weighing apparatus will be increasingly becoming one of the new direction of cosmetic industry development so as to improve skin quality.Therefore it provides to be adjustable skin micro- for one kind
The composition of the ecological balance is to be of great significance and wide prospect.
Summary of the invention
In view of the deficiencies of the prior art and actual demand, the present invention provide a kind of prebiotic compositions, are adjustable skin
The surface microorganism ecological balance, and then promote skin resistance, skin has been damaged in maintenance.Invention further provides the benefits
Raw member composition is used to prepare cosmetics, while replenishing water and preserving moisture, maintenance are nourished, improves the flat of skin surface Tiny ecosystem
Weighing apparatus promotes profitable strain, inhibits the breeding of harmful bacteria.
To achieve this purpose, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of prebiotic compositions, the composition includes: by weight percent
Saccharomycete/rice fermentation Product filtrate 45-65%
Xylose 01 derivatives 5-21%
Gotu Kola P.E 20-40%；
The sum of mass percent of each component is 100%.
In the present invention, saccharomycete/rice fermentation Product filtrate is selected to originate from Zhongxiang City of township glutinous rice of 30 ° of longevities of north latitude, warp
Unartificial yeast bacterium spontaneous fermentation forms, rear to extract the essential ingredient for being wherein beneficial to skin health, rich in a variety of work needed for skin
Property ingredient such as oligosaccharide, organic acid, polypeptide, amino acid etc..The simple and fast probiotics common by skin of energy is (such as: pentose cream
Bacillus, gram this micrococcus luteus etc.) metabolic activity be absorbed and utilized, without by pathogenic bacteria common in skin (such as: acne propionic acid bar
Bacterium, Staphylococcus aureus) it is absorbed and utilized, to help the beneficial flora in skin to grow up healthy and sound, and Reverse transcriptase pathogenic bacteria
Growth and breeding establishes the good probiotics ecological environment for being beneficial to skin；There is quickly activation Skin Cell simultaneously, inhibit skin
Inflammation strengthens the effect of skin cutin protective barrier.
The xylose 01 derivatives derive from natural plants, and adjustable skin moisture flowing is rebuild skin texture and protected
Skin moisture is held, makes skin that can become more resistance when in face of environmental stimuli.
The Gotu Kola P.E is organic Gotu Kola P.E, by French ECOCERT Organic certification, naturally without pair
Effect more meets the organic skin care trend of health of modern's pursuit.Contain Asiaticoside, ursolic acid, dimension life in the extract
Plain C and a variety of organic acids have calm, anti-inflammatory, antibacterial protective action, moreover it is possible to pass through the mild stripping to the old cutin of skin
It falls, promotes skin metabolism, it is tender white glossy to enable skin, while activating update skin cell.
As natural saccharomycete/rice fermentation Product filtrate, organic Gotu Kola P.E and xylose 01 derivatives,
It is not only nontoxic to skin, harmless, non-stimulated and safe and non-toxic without sensitization, but also synergistic effect, this hair can be generated
It is bright to be not necessarily to add other compositions, only by three kinds of substances described in combination matching, prebiotic compositions can be obtained, are specifically promoted
Growth into beneficial bacterium is bred, and the beneficial flora of skin surface is enhanced.It is colonized by occupy-place, competition nutrition and secretion inhibiting substances
Etc. come the growth that inhibits harmful bacteria, the Tiny ecosystem of imbalance is made to be restored to the substance of normal condition.
The saccharomycete/rice fermentation Product filtrate mass percent is 45-65%, for example, can be 45%, 48%,
50%, 52%, 55%, 56%, 58%, 60%, 62%, 64% or 65%, preferably 55-64%.
The mass percent of the xylose 01 derivatives is 5-21%, for example, can be 5%, 6%, 7%, 8%, 9%,
10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20 or 21%, preferably 13-18%.
The mass percent of the Gotu Kola P.E is 20-40%, for example, can be 20%, 22%, 23%, 24%,
25%, 26%, 28%, 29%, 30%, 32%, 34%, 35%, 36%, 37%, 39% or 40%, preferably 22-28%.
Strengthen beneficial flora, make probiotics relative to harmful bacteria advantageously, effective method be by provide benefit
The nutrient of raw bacterium enhances the beneficial flora of skin surface, i.e., by promoting probiotics for probiotics supplement and nutrition
Growth and holding balance.In the present invention, saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and Gotu Kola P.E exist
It is synergistic within the scope of quality proportioning of the present invention, the proliferation of probiotics is effectively facilitated, the growth of harmful bacteria is inhibited, is made prebiotic
Bacterium occupy-place field planting becomes dominant microflora；Three kinds of components have both double effects, can both promote the proliferation of probiotics and then promote flesh
Skin is to the absorption of nutrition and resists harmful bacteria damage, and directly maintenance can nourish skin, significantly improves skin to nutrition
It is absorbed and utilized, improves skin microcirculation, realize that skin care is got twice the result with half the effort.
Preferably, the xylose 01 derivatives include xylitol glucoside, anhydro xylitol and xylitol.
Preferably, the mass ratio of the xylitol glucoside, anhydro xylitol and xylitol is (4-5): (3-4): (1-
2) 4:4:2 or 5:4:1, preferably 5:4:1 be can be, such as.
Xylose 01 derivatives used in the present invention include 3 kinds of ingredients, and the 1st kind of chemical combination for being derived from glucose and xylose alcohol is anti-
Xylitol glucoside made of answering；2nd kind is anhydro xylitol；3rd kind is xylitol.In quality proportioning model of the present invention
The growth of beneficial bacterium can be effectively facilitated in enclosing, and adjust skin Tiny ecosystem.
Second aspect, the present invention provide a kind of method for preparing prebiotic compositions as described in relation to the first aspect, the side
Method includes the following steps: to mix saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and organic Gotu Kola P.E equal
Even, constant temperature stirring, filtering obtains prebiotic compositions.
Preferably, the temperature of the constant temperature is 35-45 DEG C, such as can be 35 DEG C, 36 DEG C, 38 DEG C, 40 DEG C, 42 DEG C or 45
DEG C, preferably 40 DEG C.
Preferably, the revolving speed of the stirring be 250-350rpm, such as can be 250rpm, 260rpm, 270rpm,
280rpm, 290rpm, 300rpm, 310rpm, 320rpm, 330rpm, 340rpm or 350rpm, preferably 300rpm.
Preferably, the time of constant temperature stirring is 15-25min, for example, can be 15min, 16min, 18min,
20min, 22min, 24min or 25min, preferably 20min.
Preferably, described to be filtered into micro porous filtration.
Preferably, the aperture of the micropore be 400-600 mesh, such as can be 400 mesh, 420 mesh, 450 mesh, 500 mesh,
550 mesh or 600 mesh, preferably 500 mesh.
Preferably, described method includes following steps: by saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and
Gotu Kola P.E is uniformly mixed, and 35-45 DEG C of constant temperature stirring, the revolving speed of stirring is 250-350rpm, and the time of stirring is 15-
25min obtains prebiotic compositions by the micro porous filtration of 400-600 mesh.
The third aspect, the present invention provide a kind of cosmetics, including prebiotic compositions as described in relation to the first aspect.
Preferably, the cosmetics include any one of Essence, lotion, facial mask, face cream or surfactant or at least two
The combination of kind.
Preferably, the additive amount of the prebiotic compositions be 0.01-25wt%, such as can be 0.01wt%,
0.05wt%, 0.1wt%, 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%,
9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%,
20wt%, 21wt%, 22wt%, 23wt%, 24wt% or 25wt%, preferably 0.1-20wt%.
Fourth aspect, the present invention provide a kind of lotion, including prebiotic compositions as described in relation to the first aspect.
Preferably, the lotion further includes water phase, oil phase and auxiliary material.
Preferably, the water phase includes glycerol, xanthan gum, EDETATE SODIUM, Sodium Hyaluronate, glycine betaine, panthenol or card wave
Any one of nurse 941 or at least two combination, preferably glycerol, xanthan gum, EDETATE SODIUM, Sodium Hyaluronate, glycine betaine,
The combination of panthenol and Carbopol 941.
Preferably, the oil mutually includes dimethyl silicone polymer, cetostearyl alcohol, caprylic/capric triglyceride, the wooden fruit of cream
Any one of oil, polysorbate -20, methyl hydroxybenzoate or Nipasol or at least two combination, preferably poly dimethyl
Siloxanes, cetostearyl alcohol, caprylic/capric triglyceride, shea butter, polysorbate -20, methyl hydroxybenzoate and Nipasol
Combination.
Preferably, the auxiliary material includes any one of 1,2- hexylene glycol, parahydroxyacet-ophenone or aminomethyl propanol or extremely
Few two kinds of combination, the combination of preferably 1,2- hexylene glycol, parahydroxyacet-ophenone and aminomethyl propanol.
Preferably, additive amount of the prebiotic compositions in lotion be 8-15wt%, such as can be 8wt%,
9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt% or 15wt%.
5th aspect, the present invention provides a kind of strong skin facial mask, including prebiotic compositions as described in relation to the first aspect.
Preferably, the strong skin facial mask further includes water phase and auxiliary material.
Preferably, the water phase includes glycerol, 1,3-PD, xanthan gum, hydroxyethyl cellulose, Sodium Hyaluronate or urine
Any one of Bursin or at least two combination, preferably glycerol, 1,3-PD, xanthan gum, hydroxyethyl cellulose, transparent
The combination of matter acid sodium and allantoin.
Preferably, the auxiliary material includes 1,2- hexylene glycol and/or parahydroxyacet-ophenone.
Preferably, additive amount of the prebiotic compositions in strong skin facial mask is 8-12wt%, such as be can be
8wt%, 9wt%, 10wt%, 11wt% or 12wt%.
6th aspect, the present invention provides a kind of Essence, including prebiotic compositions as described in relation to the first aspect.
Preferably, the Essence further includes water phase and auxiliary material.
Preferably, the water phase includes glycerol, 1,3-PD, Sodium Hyaluronate, allantoin, glycine betaine, panthenol, Chinese life
Any one of glue or butanediol or at least two combination, preferably glycerol, 1,3-PD, Sodium Hyaluronate, allantois
The combination of element, glycine betaine, panthenol, xanthan gum and butanediol.
Preferably, the auxiliary material includes 1,2- hexylene glycol and/or parahydroxyacet-ophenone.
Preferably, additive amount of the prebiotic compositions in Essence be 8-15wt%, such as can be 8wt%,
9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt% or 15wt%.
In the present invention, by adding suitable prebiotic compositions, promote skin to effective in lotion, facial mask and Essence
Ingredient is absorbed and utilized, and adjusts skin microecological balance, inhibits harmful bacteria breeding；Prebiotic compositions are by adjusting micro-ecological bacterial
Group promotes skin self-regeneration, improves resistance, while being aided with the ingredient of skin care nourishing, fundamentally improves skin state.
Compared with prior art, the invention has the following beneficial effects:
(1) prebiotic compositions of the invention are derivative by combination matching saccharomycete/rice fermentation Product filtrate, xylitol
Object and Gotu Kola P.E, adjust skin Tiny ecosystem balance, promote the proliferation of probiotics, by occupy-place be colonized competition nutrition at
Point, while the growth that metabolin inhibits harmful bacteria is secreted, so that the Tiny ecosystem of imbalance is restored to normal condition；
(2) prebiotic compositions of the invention not only promote the proliferation of skin surface beneficial bacterium, and composition itself can also be grown
Skin is supported, slows down skin moisture loss, adjusts acid-base scale of skin, double effects make skin care get twice the result with half the effort；
(3) composition of the invention is without side-effects safely, uses natural component for raw material, can be used for the system of a variety of cosmetics
It is standby, promote absorption of the skin to other nutritional ingredients in cosmetics, improves skin itself resistance.
Detailed description of the invention
Fig. 1 is the variation of 6 skin moisture content of the embodiment of the present invention；
Fig. 2 is the percutaneous water loss change rate of 6 skin of the embodiment of the present invention；
Fig. 3 is that 6 test zone skin shine of the embodiment of the present invention changes with time；
Fig. 4 is that 8 test zone skin ph value of the embodiment of the present invention changes with time；
Fig. 5 is that 8 test zone skin oil and fat magnitude of the embodiment of the present invention changes with time.
Specific embodiment
Further to illustrate technological means and its effect adopted by the present invention, below by way of specific embodiment come into
One step illustrates technical solution of the present invention, but the present invention is not limited in scope of embodiments.
Raw material:
Saccharomycete/rice fermentation Product filtrate buying is in Angel Yeast Co., Ltd；
The buying of xylose 01 derivatives matches Bicc Public Ltd. Co in France；
Organic Gotu Kola P.E buying is in France Chinese mugwort than Europe plant material company；
I) prebiotic compositions
Embodiment 1
A kind of prebiotic compositions, the composition include following component by mass percentage:
Saccharomycete/rice fermentation Product filtrate 56%, xylose 01 derivatives 17%, organic Gotu Kola P.E 27%.
The preparation method is as follows:
Weigh saccharomycete/rice fermentation Product filtrate according to the above ratio, xylose 01 derivatives, organic Gotu Kola P.E,
By temperature control at 40 DEG C, control mixing speed is 300r/min, and constant temperature stirs 20min, stirs evenly, the filtering of 500 mesh of micropore
?.
Embodiment 2
A kind of prebiotic compositions, the composition include following component by mass percentage:
Saccharomycete/rice fermentation Product filtrate 64%, xylose 01 derivatives 13%, organic Gotu Kola P.E 23%.
The preparation method is as follows:
Weigh saccharomycete/rice fermentation Product filtrate according to the above ratio, xylose 01 derivatives, organic Gotu Kola P.E,
By temperature control at 40 DEG C, control mixing speed is 300r/min, and constant temperature stirs 20min, stirs evenly, the filtering of 550 mesh of micropore
?.
Embodiment 3
A kind of prebiotic compositions, the composition include following component by mass percentage:
Saccharomycete/rice fermentation Product filtrate 60%, xylose 01 derivatives 16%, organic Gotu Kola P.E 24%.
The preparation method is as follows:
Weigh saccharomycete/rice fermentation Product filtrate according to the above ratio, xylose 01 derivatives, organic Gotu Kola P.E,
By temperature control at 40 DEG C, control mixing speed is 300r/min, and constant temperature stirs 20min, stirs evenly, the filtering of 450 mesh of micropore
?.
Embodiment 4
A kind of prebiotic compositions, the composition include following component by mass percentage:
Saccharomycete/rice fermentation Product filtrate 45%, xylose 01 derivatives 20%, organic Gotu Kola P.E 35%.
The preparation method is as follows:
Weigh saccharomycete/rice fermentation Product filtrate according to the above ratio, xylose 01 derivatives, organic Gotu Kola P.E,
By temperature control at 35 DEG C, control mixing speed is 350r/min, and constant temperature stirs 15min, stirs evenly, the filtering of 400 mesh of micropore
?.
Embodiment 5
A kind of prebiotic compositions, the composition include following component by mass percentage:
Saccharomycete/rice fermentation Product filtrate 52%, xylose 01 derivatives 8%, organic Gotu Kola P.E 40%.
The preparation method is as follows:
Weigh saccharomycete/rice fermentation Product filtrate according to the above ratio, xylose 01 derivatives, organic Gotu Kola P.E,
By temperature control at 45 DEG C, control mixing speed is 250r/min, and constant temperature stirs 25min, stirs evenly, the filtering of 600 mesh of micropore
?.
Comparative example 1
Compared with Example 2, in addition to saccharomycete/rice fermentation Product filtrate 35%, xylose 01 derivatives 25%, You Jiji
It avenges except careless extract 40%, other conditions are the same as embodiment 2.
Comparative example 2
Compared with Example 2, in addition to saccharomycete/rice fermentation Product filtrate 70%, xylose 01 derivatives 20%, You Jiji
It avenges except careless extract 10%, other conditions are the same as embodiment 2.
Comparative example 3
Compared with Example 2, in addition to not adding saccharomycete/rice fermentation Product filtrate, and xylose 01 derivatives 30%, have
Except machine Gotu Kola P.E 70%, other conditions are the same as embodiment 2.
Comparative example 4
Compared with Example 2, in addition to not adding xylose 01 derivatives, and saccharomycete/rice fermentation Product filtrate 70%, have
Except machine Gotu Kola P.E 30%, other conditions are the same as embodiment 2.
Comparative example 5
Compared with Example 2, in addition to not adding organic xylitol derivative, and saccharomycete/rice fermentation Product filtrate
70%, except xylose 01 derivatives 30%, other conditions are the same as embodiment 2.
Comparative example 6
Compared with Example 2, other than only adding saccharomycete/rice fermentation Product filtrate, other conditions are same
Embodiment 2.
Comparative example 7
Compared with Example 2, other than only adding xylose 01 derivatives, other conditions are the same as embodiment 2.
Comparative example 8
Compared with Example 2, other than only adding organic Gotu Kola P.E, other conditions are the same as embodiment 2.
II) measure of merit
1) proliferation of probiotics growth test
1. the preparation of sample
Embodiment 1-5 and comparative example 1-8 are respectively added in tryptone culture medium (USP), additive amount 0.5%,
Setting sterile water is control group, and probiotics Ke Shiku micrococcus luteus and Lactobacillus pentosus are inoculated in respectively in above-mentioned culture medium,
6h and for 24 hours rear plate count calculate the amount of probiotics, influence and effect of the measurement to growth of probiotics situation.Strain is purchased from Guangdong
Culture Collection is saved, the results are shown in Table 1.
1 proliferation of probiotics of table grows test result
As shown in Table 1, in saccharomycete of the present invention/rice fermentation Product filtrate, xylose 01 derivatives and organic accumulated snow
The proliferation of beneficial bacterium can be effectively facilitated in the ratio range of careless extract.Comparing embodiment 2 and comparative example 1-2 it is found that saccharomycete/
The additive amount of rice fermentation Product filtrate it is excessive or it is very few influence beneficial bacterium proliferation；Comparing embodiment 2 and comparative example 3-5 can
Know, saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and organic Gotu Kola P.E three are synergistic, lack one not
Can, the missing of any component significantly affects the accumulation beneficial to bacteria biomass；Comparing embodiment 2 and comparative example 6-8 is it is found that single
The saccharomycete of component/rice fermentation Product filtrate, xylose 01 derivatives or organic Gotu Kola P.E make the proliferation of beneficial bacterium
With unobvious, the proliferation of beneficial bacterium only can be just remarkably promoted under the conditions of three's combination matching.
2) competitive growth test
Embodiment 1-5 and comparative example 1-8 are respectively added in tryptone culture medium (USP), additive amount 0.5%,
Probiotics Ke Shiku micrococcus luteus and pathogen staphylococcus aureus are inoculated in above-mentioned culture medium simultaneously, in 6h and for 24 hours after
Plate count calculates the amount of probiotics and pathogen, measures prebiotic compositions when probiotics and pathogen exist simultaneously to bacterium
The influence and effect of group's condition of production.Strain is purchased from Guangdong Province's Culture Collection, the results are shown in Table 2.
The competitive production test result of table 2
As shown in Table 2, after using prebiotic compositions of the invention, the quantity of probiotics Ke Shiku micrococcus luteus is mentioned
Height, but the quantity of pathogen staphylococcus aureus is in reduced trend.Illustrate saccharomycete in prebiotic compositions of the present invention/big
Rice tunning filtrate, xylose 01 derivatives and organic Gotu Kola P.E can promote the growth of probiotics, then to pathogen
It will not promote its growth, can make pathogen due to a lack of food and nutrition instead and quantity gradually decreases, and inhibit growth of pathogenic bacteria
Effect.Comparing embodiment 2 and comparative example 1-2 are it is found that saccharomycete/rice fermentation Product filtrate additive amount is excessive or very few equal
Prebiotic compositions are reduced to the proliferation of beneficial bacterium, weaken the inhibiting effect to harmful bacteria；Comparing embodiment 2 and comparative example 3-5
It is found that saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and organic Gotu Kola P.E three are synergistic, one is lacked
It can not；Comparing embodiment 2 and comparative example 6-8 are it is found that be used alone saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives
The proliferation of beneficial bacterium can not be remarkably promoted with component any in organic Gotu Kola P.E, it is micro- to the inhibiting effect of harmful bacteria
It is weak.
III) cosmetics
Lotion of the embodiment 6 containing prebiotic compositions
Lotion is prepared using the prebiotic compositions of optimum embodiment 2, specific formula is as shown in table 3 below:
The formula of 3 prebiotic compositions lotion of table
Above-mentioned emulsion, preparation method are as follows:
1, addition phase raw material parahydroxyacet-ophenone is dissolved by heating in 1,2- hexylene glycol to clear in advance, it is spare；
2, water phase is put into emulsion pot, is stirred evenly, heating stirring is to 75-85 DEG C；
3, oil is mutually put into oil mutually to prepare in pot, is stirred evenly, heating stirring is to 75-85 DEG C；
4, material in oily phase pot is pumped into emulsion pot, is stirred evenly, then will vacuumized in emulsion pot, emulsifying
10 minutes；
5,15 minutes are kept the temperature, then opens cooling and is water-cooled to 40 DEG C, addition phase and prebiotic compositions are added, stirring is
It is even；
6,35 DEG C are cooled to, qualified discharging is examined.
Comparative example 9
Compared with Example 6, in addition to the prebiotic compositions of the prebiotic compositions alternative embodiment 2 using comparative example 3
Except, other conditions are the same as embodiment 6.
Comparative example 10
Compared with Example 6, in addition to the prebiotic compositions of the prebiotic compositions alternative embodiment 2 using comparative example 4
Except, other conditions are the same as embodiment 6.
Comparative example 11
Compared with Example 6, in addition to the prebiotic compositions of the prebiotic compositions alternative embodiment 2 using comparative example 5
Except, other conditions are the same as embodiment 6.
Comparative example 12
Compared with Example 6, other than not adding prebiotic compositions, other conditions are the same as embodiment 6.
Skin moisture content and skin moisture are lost the test of (TEWL)
1, test equipment
The skin moisture content Corneometer test of German Courage+Khazaka company (German CK company) manufacture
Probe.The skin moisture of German Courage+Khazaka company (German CK company) manufacture is lost (TEWL) Tewameter
TM300 test probe.
2, test method
Moisture measurement is using universally acknowledgedMethod --- capacitance method.Moisture of skin stream
It loses TEWL and parameter is very important to the function of assessment moisture of skin protective layer, have been obtained in the world very extensive
Approve.Protective layer of skin is more intact, and the content of moisture will be higher, and the numerical value of skin water loss TEWL is lower.It is tested
Principle derives from Fick Fick's law of diffusion:
3, early-stage preparations are tested
It is tested as follows using embodiment 6 and the lotion of comparative example 9-12, chooses sensitive dry skin crowd 60, year
Age at 20~45 years old, is randomly divided into 5 groups, every group of 7 males, 8 women.Any product cannot be used within 15 days before recipient site
(cosmetics or topical drug or health care product for oral administration).Before test, it is desirable that subject cleans both hands forearm, into 22 ± 1 DEG C of temperature,
Sit quietly 30min in the constant temperature and humidity room of humidity 50 ± 5%, and keeps relaxation state.Then it is drawn in tester or so forearm side
3*3cm out2The square Experimental Area of size, using left arm as the test zone of moisturizer, the corresponding symmetrical region of right arm is
Blank control, then the moisture content that probe detects each Test sites is tested with Corneometer, it is repeated 5 times, obtains every respectively
The average value of secondary test records data.It the results are shown in Table 4.Skin moisture value is calculated by different time intervals moisture content of skin
Change rate and skin water loss change rate, calculation formula are as follows:
Skin moisture value change rate=[moisture content of skin (sample)-moisture content of skin (control)]/moisture content of skin is (right
According to) × 100%
Skin water loss change rate=[TEWL value (sample)-TEWL value (control)]/TEWL (control) × 100%；
Skin moisture content result of variations is shown in Fig. 1, and the percutaneous water loss change rate result of skin is shown in Fig. 2.
4 different time intervals moisture content of skin (%) of table
| Time interval (h) | Embodiment 6 | Comparative example 9 | Comparative example 10 | Comparative example 11 | Comparative example 12 |
| 0 | 36.25 | 35.29 | 35.50 | 36.32 | 36.05 |
| 0.5 | 61.63 | 43.16 | 52.62 | 47.29 | 42.13 |
| 1.0 | 65.29 | 42.44 | 53.33 | 47.05 | 40.32 |
| 1.5 | 63.51 | 43.72 | 56.84 | 48.05 | 39.64 |
| 2.0 | 61.71 | 45.37 | 52.77 | 45.83 | 39.59 |
| 2.5 | 60.44 | 45.25 | 50.85 | 47.45 | 40.06 |
| 3.0 | 62.18 | 45.77 | 50.01 | 49.34 | 40.21 |
By Fig. 1-2 it is found that comparing embodiment 6 shows the lotion containing prebiotic compositions of the invention with comparative example 12
With good moistening effect, keratoderma moisture content can be dramatically increased, reduces the external water loss of skin.Compare reality
Example 6 and comparative example 9-12 are applied it is found that synergistic between prebiotic compositions each component of the invention, indispensable, any component
Missing significantly reduce lotion comprehensive performance.
The test of skin shine
1, test equipment
Skin shine tester Glossymeter GL200；U.S. Canfield sci VISIA-CR.
2, test method
Skin shine measurement is that whether health is than more objective method for analyzing skin.In general, numerical value is higher, skin
Health degree it is better.
3, early-stage preparations are tested
Selection example 6 and comparative example 12 are tested as follows, choose the personnel 30 that face skin has acne, red swelling of the skin
Name, the age, men and women was fifty-fifty at 20~45 years old.Volunteer or so cheek is randomly choosed, side uses embodiment 6, and the other side uses
Comparative example 12；It tests in the last week, recipient site must not use intimate cosmetics；According to test subregion, subject is every
It respectively uses a test sample sooner or later, and by personal habits use, (subject's face must not use and survey applying amount during test
The similar cosmetics of test agent).
Tested region is measured with instrument before using sample and using after sample 2 weeks, 4 weeks, 6 weeks, 8 weeks.Test
On the same day, volunteer does not use sample, and needs temperature (22 ± 1) DEG C indoors, quiet in the constant temperature and humidity room of humidity (55 ± 5) %
30min is sat, and keeps relaxation state.Same position is surveyed 3 times, takes its average value, and use VISIA-CR photographic analysis acneform
State.As a result see Fig. 3
From the figure 3, it may be seen that after embodiment 6, skin shine is in rising trend within 8 weeks test periods, it is higher than and uses
Before, and at the 8th week, paired t-test before relative usage illustrates as a result, there are significant difference (P < 0.05) in tested area
Domain, embodiment 6 have the effect of improving skin shine.Each test point within 8 weeks of comparative example 12, pairing t inspection before relative usage
It tests as a result, there are no significant difference (P > 0.05), illustrates comparative example 12 to the promotion effect of tested region glossiness without conspicuousness
Difference.It is noted that taken pictures by VISIA-CR, discovery is obviously subtracted using subject's acne on the face of embodiment 6
It is few.So prebiotic compositions of the present invention can reduce acne and generate, improve skin gloss by improving skin microecological balance
Degree makes skin tend to health.
Strong skin facial mask of the embodiment 7 containing prebiotic compositions
Strong skin facial mask is prepared using the prebiotic compositions of optimum embodiment 2, specific formula is as shown in table 5 below:
5 prebiotic compositions of table are good for the formula of skin facial mask
Above-mentioned mask, preparation method are as follows:
1, addition phase raw material parahydroxyacet-ophenone is dissolved by heating into matter clear in 1,2- hexylene glycol in advance, it is spare；
2, Aqueous Phase Raw Material is put into deionized water, is heated to 75-85 DEG C, stirring is to being uniformly dissolved；
3, water phase is cooled to 60 DEG C, is slowly added to the para hydroxybenzene dissolved in 1,2- hexylene glycol in advance while stirring
Ethyl ketone, stirring is to being uniformly dissolved；
4,40 DEG C are cooled to, prebiotic compositions are added, stir evenly, is cooled to 35 DEG C, 300 mesh go out after surveying pH qualification
Material.
Comparative example 13
Compared with Example 7, other than not adding prebiotic compositions, other conditions are the same as embodiment 7.
Comparative example 14
A kind of any one commercially available moisturizing is releived facial mask.The facial mask contains Sodium Hyaluronate, allantoin, panthenol, Curacao
Aloe (ALOE BARBADENSIS) leaf extract, the effective components such as cucumber (CUCUMIS SATIVUS) berry extract, declares have
There is preferable moisturizing to releive effect.
Normal individual trial evaluation test
1, test population:
90 people of personnel for selecting face skin drying, red swelling of the skin, convulsion to itch, the age, men and women was fifty-fifty at 18-28 years old, at random
It is divided into 3 groups, every group of 15 males, 15 women.It is required that subject's health, it can be by Normalization rule cosmetics, to makeup
Product hyperesthesia can be judged accurately after use.
2, experimental procedure:
It is tested as follows using embodiment 7, comparative example 13-14, before subject tries out sample, first voluntarily face cleaning is dried
Afterwards, fixed point is persistently used 30 days using primary daily, and observation uses a skin condition after 1 month.Subject is in experimental period
Between cannot use other any cosmetics or other drugs, avoid staying up late, smoke and keep bland diet.To sample in use process
Product moisturizing degree, degree of highlighting, mildness, sophistication, elasticity are evaluated, and wherein highest is divided into 5 points, minimum to be divided into 1 point.
3, test result
The practical effect of sample is tracked and recorded, the feedback opinion and finishing analysis of collecting test person, statistics
It the results are shown in Table 6.
6 normal individual trial result average value of table
| Evaluation result | Embodiment 7 | Comparative example 13 | Comparative example 14 |
| Moisturizing degree | 4.50 | 3.00 | 3.00 |
| Degree of highlighting | 3.54 | 2.50 | 3.25 |
| Mildness | 4.50 | 4.50 | 4.50 |
| Sophistication | 4.25 | 1.5 | 1.5 |
| Elastic effect | 4.00 | 1.75 | 2.00 |
By 6 result of table as it can be seen that comparing embodiment 7 and comparative example 13-14 are it is found that prebiotic compositions of the invention can be obvious
Improve moisturizing degree, sophistication and the elastic effect of skin.
In addition, 75% people indicates the obvious water profit of skin in crowd using embodiment 7, red and swollen, analgesic, antipruritic is eliminated
Effect is obvious, and there is good moisturizing to releive effect；25% people indicates that skin has a water moisture feeling, and red and swollen fading and convulsion symptom of itching subtract
Gently, there is good moisturizing to releive effect；100% use crowd indicates that dry skin is showed no using 7 face of embodiment to be taken off
The side effects such as skin, tingling sensation, inflammation, skin gradually becomes water Rinsing cunning after 30 days, compact full.
In crowd using comparative example 13,28% people indicates that skin has a water moisture feeling, and red and swollen fading and convulsion are itched symptom mitigation,
70% indicates that symptom has no improvements using crowd, and 2% people indicates that the pair work such as dry skin decortication, tingling sensation occurs in face
With.
In crowd using comparative example 14, only 42% people indicates skin water profit, and red and swollen and convulsion is itched symptom mitigation；Have 50%
People indicate symptom have no improvement；There is 8% people to indicate bored acne situation, red swelling of the skin and convulsion are itched exacerbation of symptoms.
Essence of the embodiment 8 containing prebiotic compositions
Strong skin facial mask is prepared using the prebiotic compositions of optimum embodiment 2, specific formula is as shown in table 7 below:
The formula of 7 prebiotic compositions Essence of table
Above-mentioned Essence, preparation method are as follows:
1, addition phase raw material parahydroxyacet-ophenone is dissolved by heating in 1,2- hexylene glycol to clear in advance, it is spare；
2, water phase is put into deionized water, is stirred evenly, heating stirring is to 75~85 DEG C；
3, keep the temperature 10 minutes, then open cooling water temperature to 60 DEG C, be slowly added to while stirring in advance 1,2- oneself two
The parahydroxyacet-ophenone dissolved in alcohol, stirring is to being uniformly dissolved；
4,40 DEG C are cooled to, prebiotic compositions are added；
5, it stirs evenly, is cooled to 35 DEG C, 300 mesh discharge after surveying pH qualification.
Comparative example 15
Compared with Example 8, other than not adding prebiotic compositions, other conditions are the same as embodiment 8.
The test of skin oil and fat amount and PH
1, test equipment
Acid-base scale of skin test probe Skin-PH-Meter PH905；Grease tester Sebumeter SM815.
2, test method
It is tested as follows using embodiment 8 and comparative example 15, selects vigorous 30 people of personnel of face skin fat secretion, year
Age, men and women was fifty-fifty at 18-28 years old, was randomly divided into 2 groups, every group of 15 males, 15 women.Before subject tries out sample, first certainly
Row face cleaning, after drying, fixed point is persistently used 60 days using primary daily, and observation uses a skin condition after 2 months.By
Examination person cannot use other any cosmetics or other drugs during test, avoid staying up late, smoke and keep bland diet.?
Tested region is measured with instrument using before sample and using after sample 2 weeks, 4 weeks, 6 weeks, 8 weeks.The test same day, volunteer
Without using sample, and temperature (22 ± 1) DEG C indoors being needed, sit quietly 30min in the constant temperature and humidity room of humidity (55 ± 5) %, and
Keep relaxation state.The test zone skin ph result that changes with time is shown in Fig. 4, and skin oil and fat amount changes with time result
See Fig. 5.
Under normal circumstances, the vigorous skin acidity of fat secretion is stronger, by Fig. 4-5 it is found that in continuous use embodiment 8
Afterwards, skin ph value is gradually increasing, and after 2 months in a healthy range, while skin oil and fat secretion is reduced, and gradually tends to water
Oil balance；Compared to comparative example 15, without apparent difference before and after use.Illustrate that prebiotic compositions of the present invention provide for skin flora
Healthy balanced diet, rebalances the skin flora being destroyed, and balance skin pH value improves skin health.
In conclusion prebiotic compositions of the present invention can not only effectively facilitate the growth of skin probiotics, inhibit harmful
Bacterium maintains the balance of skin Tiny ecosystem, can also promote skin moisture content, effective maintenance cutin.Combination of prebiotics of the invention
Object each component synergistic effect, the common microecological balance for safeguarding skin restore and reinforce skin itself self-renewing and maintenance
Ability enhances skin barrier, improves skin quality from the root, well solves that water oil is unbalance, the skins such as red and swollen, dark yellow, coarse, dry
Skin problem, while skin can be made to become water Rinsing and slided, it is compact full.
The Applicant declares that the present invention is explained by the above embodiments method detailed of the invention, but the present invention not office
Be limited to above-mentioned method detailed, that is, do not mean that the invention must rely on the above detailed methods to implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of prebiotic compositions, which is characterized in that the composition includes: by weight percent
Saccharomycete/rice fermentation Product filtrate 45-65%
Xylose 01 derivatives 5-21%
Gotu Kola P.E 20-40%；
The sum of mass percent of each component is 100%.
2. prebiotic compositions according to claim 1, which is characterized in that the composition includes: by weight percent
Saccharomycete/rice fermentation Product filtrate 55-64%
Xylose 01 derivatives 13-18%
Gotu Kola P.E 22-28%；
The sum of mass percent of each component is 100%.
3. prebiotic compositions according to claim 1 or 2, which is characterized in that the xylose 01 derivatives include xylose
Alcohol glucoside, anhydro xylitol and xylitol；
Preferably, the mass ratio of the xylitol glucoside, anhydro xylitol and xylitol is (4-5): (3-4): (1-2),
Preferably 5:4:1.
4. a kind of method for preparing prebiotic compositions as described in any one of claims 1-3, which is characterized in that the method
Include the following steps: for saccharomycete/rice fermentation Product filtrate, xylose 01 derivatives and Gotu Kola P.E to be uniformly mixed, it is permanent
Temperature stirring, filtering obtain prebiotic compositions.
5. according to the method described in claim 4, it is characterized in that, the temperature of the constant temperature is 35-45 DEG C, preferably 40 DEG C；
Preferably, the revolving speed of the stirring is 250-350rpm, preferably 300rpm；
Preferably, the time of the constant temperature stirring is 15-25min, preferably 20min；
Preferably, described to be filtered into micro porous filtration；
Preferably, the aperture of the micropore is 400-600 mesh, preferably 500 mesh.
6. method according to claim 4 or 5, which is characterized in that described method includes following steps: by saccharomycete/big
Rice tunning filtrate, xylose 01 derivatives and Gotu Kola P.E are uniformly mixed, 35-45 DEG C of constant temperature stirring, the revolving speed of stirring
Time for 250-350rpm, stirring obtains prebiotic compositions by the micro porous filtration of 400-600 mesh for 15-25min.
7. a kind of cosmetics, which is characterized in that including prebiotic compositions as described in any one of claims 1-3；
Preferably, the cosmetics include any one of Essence, lotion, facial mask, face cream or surfactant or at least two
Combination；
Preferably, the additive amount of the prebiotic compositions is 0.01-25wt%, preferably 0.1-20wt%.
8. a kind of lotion, which is characterized in that be prepared using prebiotic compositions as described in any one of claims 1-3；
Preferably, additive amount of the prebiotic compositions in lotion is 8-15wt%.
9. a kind of strong skin facial mask, which is characterized in that be prepared into using prebiotic compositions as described in any one of claims 1-3
It arrives；
Preferably, additive amount of the prebiotic compositions in strong skin facial mask is 8-12wt%.
10. a kind of Essence, which is characterized in that be prepared into using prebiotic compositions as described in any one of claims 1-3
It arrives；
Preferably, additive amount of the prebiotic compositions in Essence is 8-15wt%.
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