CN107595724B - Skin matrix and preparation method thereof and the cosmetics including it - Google Patents
Skin matrix and preparation method thereof and the cosmetics including it Download PDFInfo
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- CN107595724B CN107595724B CN201711089313.9A CN201711089313A CN107595724B CN 107595724 B CN107595724 B CN 107595724B CN 201711089313 A CN201711089313 A CN 201711089313A CN 107595724 B CN107595724 B CN 107595724B
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Abstract
The present invention provides a kind of skin matrixes and preparation method thereof and the cosmetics including it, it is related to cosmetic field, the skin matrix includes following components by weight percentage: deionized water 55%~85%, modified Schizophyllum commune Fr polysaccharides 0.1%~3%, 1,3-BDO 5%~35%, Phenoxyethanol 0.1%~0.6%, Antarctic Continent clump stalk algae extract 0.5%~5% and chicory root extract 0.5%~5%.The skin matrix can alleviate the technical issues of skin care item in the prior art have a single function, while have effects that anti-light aging, moisturizing and maintenance.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly, to a kind of skin matrix and preparation method thereof with include it
Cosmetics.
Background technique
The skin of health is soft and smooth, uniform color and flexible, as external environment changes and the tune of inherent gene
Control, the skin of people will appear the various problems such as skin sensitivity, the colour of skin are dimmed, skin is coarse, wrinkle, dark sore and acne.Cosmetics
To nursing skin, improve skin quality and promote the makings of people, there is irreplaceable role, and there are the cosmetics of efficacy effect
It is more welcomed by the people.
Light aging refers to skin for a long time by damage caused by solar radiation, show as pachylosis, thicken, relax and
The symptoms such as deep and thick wrinkle；The skin of normal human is with certain moisture-retaining capacity, the water content that skin can be maintained certain,
The problems such as resisting as internal and external factor to evaporation drying caused by skin, even chapped skin, if the moisture-retaining capacity of skin goes out
Existing problem, a series of skin problem will generate；The skin of people has certain repair ability, this is derived from epidermal cell not
Disconnected update and various growth factors are to the regenerated stimulation of skin cell.When the barrier function of human skin goes wrong
When, skin becomes more and more fragile, to be easier to be encroached on by the external world, the maintenance ability of skin can decline therewith, this performance
Lead to dry skin for skin sensitivity, redness, skin moisture content reduction.With the development in market, single component, list
The increasingly atrophy of the market of the cosmetics of one effect, and have the cosmetics of a variety of nursing effects increasingly by the joyous of people simultaneously
It meets.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of skin matrix, be had a single function with alleviating skin care item in the prior art
The technical issues of, which has effects that anti-light aging, moisturizing and maintenance simultaneously.
The second object of the present invention is to provide a kind of preparation method of above-mentioned skin matrix, the preparation method process flow
Simply, product is easy to get.
The third object of the present invention is to provide a kind of purposes of above-mentioned skin matrix.
The fourth object of the present invention is to provide a kind of skin care item, which has anti-light aging, moisturizing and maintenance
Skin-care effect.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of skin matrix includes following components by weight percentage: deionized water 55%~85%, modified schizophyllum commune
Polysaccharide 0.1%~3%, 1,3 butylene glycol 5%~35%, Phenoxyethanol 0.1%~0.6%, Antarctic Continent clump stalk algae extract
0.5%~5% and chicory root extract 0.5%~5%.
It further, by weight percentage include following components: deionized water 60%~80%, modified Schizophyllum commune Fr polysaccharides
0.3%~2.8%, 1,3 butylene glycol 5%~30%, Phenoxyethanol 0.3%~0.5%, the Antarctic Continent clump stalk algae extract 1%~
4% and chicory root extract 1%~4%；
It preferably, by weight percentage include following components: deionized water 65%~75%, modified Schizophyllum commune Fr polysaccharides
0.5%~1.8%, 1,3 butylene glycol 10%~30%, Phenoxyethanol 0.4%~0.5%, Antarctic Continent clump stalk algae extract 2%
~4% and chicory root extract 2.5%~4%.
Further, the modified Schizophyllum commune Fr polysaccharides are prepared using following methods, and the method includes by schizophyllum commune
Polysaccharide fermentation liquid is successively concentrated, ultrasonotomography, alcohol precipitation and drying step；
Preferably, the concentration includes being centrifuged Schizophyllum commune Fr polysaccharides fermentation liquid to obtain supernatant, and then supernatant is concentrated
Obtain the concentrate containing Schizophyllum commune Fr polysaccharides；
Preferably, the mass fraction of Schizophyllum commune Fr polysaccharides is 0.5%~1% in the concentrate；
Preferably, the concentration is reduced pressure；
Preferably, in the ultrasonotomography, ultrasonic device be probe type ultrasonic wave producer, the ultrasonic power 500W~
700W, 15~90min of ultrasonic time, ultrasonic temperature≤50 DEG C, ultrasonic temperature are preferably 30~50 DEG C；
Preferably, ethanol solution is added after ultrasonotomography and carries out alcohol precipitation processing；
Preferably, it is 60%~65% that concentration of alcohol in the mixing liquid obtained after ethanol solution, which is added, alcohol precipitation temperature 3~
6 DEG C, 11~14h of alcohol precipitation time；
Preferably, the volume fraction of the ethanol solution of addition is 92~96%；
Preferably, the drying mode is freeze-drying；
Preferably, the molecule of the modification Schizophyllum commune Fr polysaccharides after drying is 1 × 105Da~2 × 106Da。
A kind of preparation method of above-mentioned skin matrix, including will be modified Schizophyllum commune Fr polysaccharides, 1,3-BDO, Phenoxyethanol,
Antarctic Continent clump stalk algae extract and chicory root extract are dissolved in the step in deionized water.
Further, first modified Schizophyllum commune Fr polysaccharides are dissolved in deionized water, add 1,3-BDO, Phenoxyethanol,
Antarctic Continent clump stalk algae extract and chicory root extract simultaneously stir evenly, and obtain the skin matrix.
Further, modified Schizophyllum commune Fr polysaccharides are dissolved in deionized water, are stirred under the conditions of 85~90 DEG C, kept the temperature
After 20~60min, 40~50 DEG C are cooled to, then adds 1,3-BDO, Phenoxyethanol, Antarctic Continent clump stalk algae extract
With chicory root extract and stir evenly, obtain the skin matrix；
Preferably, the mixing speed is 400~800r/min；
Preferably, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract and after mixing evenly again is being added
It is filtered processing, obtains the skin matrix；
Preferably, mesh number when filtering is 150~250 mesh.
A kind of above-mentioned skin matrix is preparing the purposes in cosmetics.
A kind of cosmetics, including above-mentioned skin matrix.
Further, by weight percentage include 1%~40% skin matrix.
Further, the cosmetics are Essence, and the Essence includes following components in percentage by weight:
Component A: deionized water 40%~75%, acrylic acid or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymeric
Object 0.05%~0.2%, dipotassium glycyrrhizinate 0.05%~0.15% and disodium ethylene diamine tetraacetate 0.05%~0.1%；
B component: 1,3 butylene glycol 5%~15% and Sodium Hyaluronate 0.01%~0.3%；
Component C: propylene glycol 1%~3% and Phenoxyethanol 0.3%~1%；
D component: aminomethyl propanol 0.03%~0.14% and deionized water 1%~3%；
Component E: the skin matrix 1%~35%.
Further, the cosmetics are moisturizing cream, and the moisturizing cream includes following components in percentage by weight:
Component A: 1,3 butylene glycol 2%~8%, glycerol 1%~6%, Sodium Hyaluronate 0.02%~0.2% and acrylic acid
Or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymer 0.05%~0.35%；
B component: deionized water 45%~66%, dipotassium glycyrrhizinate 0.05%~0.2%, disodium ethylene diamine tetraacetate
0.05%~0.15% and xanthan gum 0.05~0.25%；
Component C: methylparaben 0.05%~0.25% and propylene glycol 1%~6%；
D component: dimethyl silicone polymer 1%~5%, Butyrospermum parkii fruit rouge 0.5%~3.5%, Trivent OCG and/
Or Triglyceride DDD 2%~5%, Queensland nut seed oil 0.5%~4%, coconut oil last of the ten Heavenly stems ester 1%~4%, tocopherol acetate
0.01%~0.05%, cetostearyl alcohol 1%~3%, propylben 0.1%~0.3%, ceteareth -6 1%
~5% and PEG-60 rilanit special 1.5%~6%；
Component E: deionized water 2%~5% and aminomethyl propanol 0.03%~0.25%；
F component: sodium acrylate and/or sodium acryloyldimethyl taurate copolymers 0.5%~2.5%；
G component: Phenoxyethanol 0.3%~0.9% and the skin matrix 5%~20%.
Compared with the prior art, the invention has the following beneficial effects:
Skin matrix provided by the invention is rich in multiple efficacies ingredient, wherein modified Schizophyllum commune Fr polysaccharides have to be protected well
Wet effect can form one layer of barrier, effective protection skin in skin, while with anti-inflammatory, can promote the maintenance ability of skin；South
Pole continent clump stalk algae extract has excellent performance of keeping humidity, has good effect to photoaging skin maintenance；Cichory root extracts
Object can be improved the repair ability of skin, accelerate the ability for rebuilding mature skin barrier function.Several effect extract compoundings, respectively
It is mutually reconciled between ingredient, acts synergistically, make the skin matrix while providing long-acting moistening effect, support ultraviolet radiation resisting institute
Bring skin aging problem reinforces the barrier protection function of skin, promotes self maintenance ability of skin.By the skin matrix
Applied to skin-care effect of the skin-protection product in terms of anti-light aging, moisturizing and maintenance in corresponding cosmetics, can be promoted.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
One aspect of the present invention provides a kind of skin matrix, by weight percentage includes following components: deionization
Water 55%~85%, modified Schizophyllum commune Fr polysaccharides 0.1%~3%, 1,3 butylene glycol 5%~35%, Phenoxyethanol 0.1%~
0.6%, Antarctic Continent clump stalk algae extract 0.5%~5% and chicory root extract 0.5%~5%.
Skin matrix provided by the invention is rich in multiple efficacies ingredient, wherein modified Schizophyllum commune Fr polysaccharides have to be protected well
Wet effect can form one layer of barrier, effective protection skin in skin, while with anti-inflammatory, can promote the maintenance ability of skin；South
Pole continent clump stalk algae extract has excellent performance of keeping humidity, has good effect to photoaging skin maintenance；Cichory root extracts
Object can be improved the repair ability of skin, accelerate the ability for rebuilding mature skin barrier function.Several effect extract compoundings, respectively
It is mutually reconciled between ingredient, acts synergistically, make the skin matrix while providing long-acting moistening effect, support ultraviolet radiation resisting institute
Bring skin aging problem reinforces the barrier protection function of skin, promotes self maintenance ability of skin.By the skin matrix
Applied to skin-care effect of the skin-protection product in terms of anti-light aging, moisturizing and maintenance in corresponding cosmetics, can be promoted.
In the present invention, the typical but non-limiting weight percent of water for example can be with are as follows: 55%, 60%, 65%, 70%,
75%, 80% or 85%.
Schizophyllum commune Fr polysaccharides are a kind of neutral exocellular polysaccharides generated by medicinal fungi schizophyllum commune submerged fermentation.It has good
Physiological function, there is good film forming, form the film clearly felt, form one layer of good moisturizing screen in skin epidermis
Barrier；Schizophyllum commune Fr polysaccharides have good anti-inflammatory activity simultaneously, can alleviate by diseases such as the caused erythemas of ultraviolet light irradiation
Shape promotes the reparation of skin.
In the present invention, the modified typical but non-limiting weight percent of Schizophyllum commune Fr polysaccharides for example can be with are as follows: 0.1%,
0.3%, 0.5%, 0.7%, 1%, 1.5%, 2%, 2.5% or 3%.
1,3-BDO is a kind of polyalcohol, is used as solvent, and the stability of product is promoted, and is imitated with certain moisturizing
Fruit, to increase the moisture retention of skin matrix.
In the present invention, the typical but non-limiting weight percent of 1,3-BDO for example can be with are as follows: 5%, 7.5%,
10%, 12.5%, 15%, 17.5%, 20%, 22.5%, 25%, 27.5%, 30%, 32.5% or 35%.
Phenoxyethanol is a kind of colourless oily liquids, has antibiotic effect, while playing the role of corrosion-resistant.
In the present invention, the typical but non-limiting weight percent of Phenoxyethanol for example can be with are as follows: 0.1%, 0.2%,
0.3%, 0.4%, 0.5% or 0.6%.
The clump stalk algae that Antarctic Continent clump stalk algae extract is grown under the adverse circumstances of the Antarctic Continent, the fucoxanthine contained
There is significant antioxidant effect with ingredients such as glutathione, the ingredients such as the fucoidin in addition contained, phloroglucinol have good
Performance of keeping humidity, and inhibit the generation of inflammatory factor.Antarctic Continent clump stalk algae extract can increase skin corium fibrocyte
Quantity and matrix generation quantity, the clinical effectiveness with pachyderma and recovery skin elasticity, while matrix metal can be inhibited
Proteinase activity protects skin by sun damage, not repair photo damaged skin.
Antarctic Continent clump stalk algae extract in the present invention is preferably bought from ELICITYL company, France, the fucose contained
Glue makes it have excellent performance of keeping humidity, while can protect skin not by sun damage, has to photoaging skin method maintenance
Good effect.
In the present invention, the Antarctic Continent clump stalk typical but non-limiting weight percent of algae extract for example can be with are as follows:
0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5%.
Chicory root extract is rich in oligofructose, has good performance of keeping humidity, and current research is shown, which extracts
Object has the function of class vitamin D, can repair the endogenetic energy power of aged cells, stimulation control differentiation, angling and exfoliating process,
The repair ability of skin is improved, the ability for rebuilding mature skin barrier function is accelerated.Therefore, chicory root extract has good
Skin repair ability.
Chicory root extract in the present invention is preferably bought from SILAB company, France, is light yellow liquid, pH for 4.5~
5.5, its oligofructose rich in can be improved the repair ability of skin, accelerate the energy for rebuilding mature skin barrier function
Power.Chicory root extract of the present invention contains 30~45g/L of total reducing sugar.
In the present invention, the typical but non-limiting weight percent of chicory root extract for example can be with are as follows: 0.5%, 1%,
1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5%.
As a preferred embodiment of the present invention, the skin matrix includes following components by weight percentage: go from
Sub- water 60%~80%, modified Schizophyllum commune Fr polysaccharides 0.3%~2.8%, 1,3 butylene glycol 5%~30%, Phenoxyethanol 0.3%~
0.5%, Antarctic Continent clump stalk algae extract 1%~4% and chicory root extract 1%~4%；Preferably, by weight percentage
Including following components: deionized water 65%~75%, modified Schizophyllum commune Fr polysaccharides 0.5%~1.8%, 1,3 butylene glycol 10%~
30%, Phenoxyethanol 0.4%~0.5%, Antarctic Continent clump stalk algae extract 2%~4% and chicory root extract 2.5%~4%；
It is further preferred that by weight percentage including following components: deionized water 66.5%, modified Schizophyllum commune Fr polysaccharides 1.5%, 1,
3- butanediol 25%, Phenoxyethanol 0.5%, Antarctic Continent clump stalk algae extract 3% and chicory root extract 3.5%.Pass through optimization
The proportion of each raw material can be further improved the mutual synergistic effect relationship between each raw material, to further increase the skin matrix
Skin effect.
As a preferred embodiment of the present invention, the modified Schizophyllum commune Fr polysaccharides are prepared using following methods, described
Method includes the steps that successively concentrated, ultrasonotomography, alcohol precipitation and drying by Schizophyllum commune Fr polysaccharides fermentation liquid.Schizophyllum commune Fr polysaccharides are high
Molecular compound has high viscosity under lower mass concentration, influences its skin sense and effect, it is therefore desirable to counterincision pleat
Granulose is modified, and reduces its molecular weight, to change its solubility and reduce viscosity.Keep its part high by ultrasonic treatment
Molecular chain rupture forms the lesser polysaccharide of molecular weight, so as to improve its solubility and viscosity.
As a preferred embodiment of the present invention, the concentration includes being centrifuged Schizophyllum commune Fr polysaccharides fermentation liquid to obtain supernatant
Then supernatant is concentrated to get the concentrate containing Schizophyllum commune Fr polysaccharides by liquid；Preferably, in the concentrate Schizophyllum commune Fr polysaccharides matter
Measuring score is 0.5%~1%；Preferably, the concentration is reduced pressure.
The mass fraction of Schizophyllum commune Fr polysaccharides is typical but non-limiting in above-mentioned preferred embodiment, in concentrate for example may be used
Think 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1%.
As a preferred embodiment of the present invention, in the ultrasonotomography, ultrasonic device is probe type ultrasonic wave producer,
Ultrasonic power 500W~the 700W, 15~90min of ultrasonic time, ultrasonic temperature≤50 DEG C, ultrasonic temperature are preferably 30~50
℃。
In above-mentioned preferred embodiment, ultrasonic power is typical but non-limiting for example can be with are as follows: 500W, 550W, 600W,
650W or 700W；Processing time in ultrasonic treatment it is typical but non-limiting for example can be with are as follows: 15min, 30min, 45min,
60min, 75min or 90min；Ultrasonic temperature is typical but non-limiting for example can be with are as follows: 30 DEG C, 35 DEG C, 40 DEG C, 45 DEG C or 50
℃。
As a preferred embodiment of the present invention, ethanol solution is added after ultrasonotomography and carries out alcohol precipitation processing；Ethyl alcohol is added
In the mixing liquid obtained after solution concentration of alcohol be 60%~65%, 3~6 DEG C of alcohol precipitation temperature, 11~14h of alcohol precipitation time；It is excellent
Selection of land, the volume fraction of the ethanol solution of addition are 92~96%.
In above-mentioned preferred embodiment, concentration of alcohol is added after ethanol solution in obtained mixing liquid for example can be with are as follows:
60%, 61%, 62%, 63%, 64% or 65%；Alcohol precipitation temperature for example can be with are as follows: 3 DEG C, 4 DEG C, 5 DEG C or 6 DEG C；Alcohol precipitation time example
It such as can be with are as follows: 11h, 12h, 13h or 14h；The volume fraction of ethanol solution is, for example, 92%, 93%, 94%, 95% or 96%.
As a preferred embodiment of the present invention, the drying mode is freeze-drying；Preferably, the modification after drying is split
The molecule of gill fungus polysaccharide is 1 × 105Da~2 × 106Da。
Solution after ultrasonic treatment is first carried out to alcohol precipitation to carry out freeze-drying process again and further can effectively control to split pleat
The decomposition of granulose, to further increase the solubility of modified Schizophyllum commune Fr polysaccharides.
Another aspect of the present invention provides a kind of preparation method of above-mentioned skin matrix, including will to be modified schizophyllum commune more
Sugar, 1,3 butylene glycol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract are dissolved in the step in deionized water.
The preparation method process flow is simple, and product is easy to get.
As a preferred embodiment of the present invention, first modified Schizophyllum commune Fr polysaccharides are dissolved in deionized water, add 1,3-
Butanediol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract simultaneously stir evenly, and obtain the skin matrix.
Modified Schizophyllum commune Fr polysaccharides, which are first dissolved in deionized water, can be such that modified Schizophyllum commune Fr polysaccharides sufficiently dissolve, and then be added 1,3- simultaneously again
Butanediol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract, 1,3-BDO can help to dissolve the Antarctic Continent
Clump stalk algae extract and chicory root extract, increase the stability of solution entirety.
As a preferred embodiment of the present invention, modified Schizophyllum commune Fr polysaccharides are dissolved in deionized water, in 85~90 DEG C of items
Be stirred under part, keep the temperature 20~60min after, be cooled to 40~50 DEG C, then add 1,3-BDO, Phenoxyethanol,
Antarctic Continent clump stalk algae extract and chicory root extract simultaneously stir evenly, and obtain the skin matrix；Preferably, the stirring speed
Degree is 400~800r/min.It dissolves modified Schizophyllum commune Fr polysaccharides sufficiently, 1,3- fourth two is added after then cooling down again
Alcohol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract, can be such that various substances are substantially soluble in water, improve
The skin effect of skin matrix.
In above-mentioned preferred embodiment, the solution temperature of modified Schizophyllum commune Fr polysaccharides be it is typical but non-limiting for example
Are as follows: 85 DEG C, 86 DEG C, 87 DEG C, 88 DEG C, 89 DEG C or 90 DEG C, soaking time is typical but non-limiting for example are as follows: 20min, 30min,
40min, 50min or 60min, the modified dissolved cooling temperature of Schizophyllum commune Fr polysaccharides are typical but non-limiting for example are as follows: 40 DEG C,
42 DEG C, 44 DEG C, 46 DEG C, 48 DEG C or 50 DEG C.
As a preferred embodiment of the present invention, 1,3-BDO, Phenoxyethanol, Antarctic Continent clump stalk algae extract is being added
It is filtered processing again with chicory root extract and after mixing evenly, obtains the skin matrix；Preferably, mesh number when filtering
For 150~250 mesh.Undissolved substance and granule foreign can be separated by filtering, guarantees the presentation quality of skin matrix.
The third aspect of the invention provides a kind of above-mentioned skin matrix and is preparing the purposes in cosmetics.
Fourth object of the present invention is to provide a kind of cosmetics, including above-mentioned skin matrix.The skin care item have anti-
The skin-care effect of light aging, moisturizing and maintenance.Cosmetics in the present invention are skin care category cosmetics, including moisturizing class is made up
Product, anti-light aging class cosmetics and maintenance class cosmetics.Cosmetics in the present invention can be Essence, be also possible to moisturizing
Cream is also possible to skin cream, can also be other skin-protection products, such as facial mask.
As a preferred embodiment of the present invention, the cosmetics include 1%~40% skin care by weight percentage
Matrix.
In the cosmetics of above-mentioned preferred embodiment, the content of skin matrix is typical but non-limiting for example can be with
Are as follows: 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35% or 40%.
As a preferred embodiment of the present invention, the cosmetics are Essence, and the Essence includes following weight hundred
Divide the component of ratio:
Component A: deionized water 40%~75%, acrylic acid or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymeric
Object 0.05%~0.2%, dipotassium glycyrrhizinate 0.05%~0.15% and disodium ethylene diamine tetraacetate 0.05%~0.1%；
B component: 1,3 butylene glycol 5%~15% and Sodium Hyaluronate 0.01%~0.3%；
Component C: propylene glycol 1%~3% and Phenoxyethanol 0.3%~1%；
D component: aminomethyl propanol 0.03%~0.14% and deionized water 1%~3%；
Component E: the skin matrix 1%~35%.
It is each in component A, B component, component C, D component and component E in the Essence that the preferred embodiment for the present invention provides
What the percentage composition of raw material was calculated on the basis of the weight of entire Essence.
In component A, the typical but non-limiting percentage composition of deionized water for example can be with are as follows: 40%, 45%, 50%,
55%, 60%, 65%, 70% or 75%；Acrylic acid or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymer it is typical but
Unrestricted percentage composition for example can be with are as follows: 0.05%, 0.1%, 0.15% or 0.2%；Dipotassium glycyrrhizinate typical case but non-limit
The percentage composition of property processed for example can be with are as follows: 0.05%, 0.07%, 0.1%, 0.12% or 0.15%；Disodium ethylene diamine tetraacetate
Typical but non-limiting percentage composition for example can be with are as follows: 0.05%, 0.06%, 0.07%, 0.08%, 0.09% or 0.1%.
In B component, the typical but non-limiting percentage composition of 1,3-BDO for example can be with are as follows: 5%, 7%, 9%,
11%, 13% or 15%；The typical but non-limiting percentage composition of Sodium Hyaluronate for example can be with are as follows: 0.01%, 0.05%,
0.1%, 0.15%, 0.2%, 0.25% or 0.3%.
In component C, the typical but non-limiting percentage composition of propylene glycol for example can be with are as follows: 1%, 1.2%, 1.5%,
1.7%, 2%, 2.2%, 2.5%, 2.8% or 3%；The typical but non-limiting percentage composition of Phenoxyethanol for example can be with are as follows:
0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1%.
In D component, the typical but non-limiting percentage composition of aminomethyl propanol for example can be with are as follows: 0.03%, 0.05%,
0.07%, 0.09%, 0.1%, 0.12% or 0.14%；The typical but non-limiting percentage composition of deionized water for example can be with
Are as follows: 1%, 1.5%, 2%, 2.5% or 3%.
In component E, the typical but non-limiting percentage composition of skin matrix for example can be with are as follows: 1%, 5%, 10%, 15%,
20%, 25% or 30%.
As a preferred embodiment of the present invention, the cosmetics are moisturizing cream, and the moisturizing cream includes following heavy
Measure the component of percentage:
Component A: 1,3 butylene glycol 2%~8%, glycerol 1%~6%, Sodium Hyaluronate 0.02%~0.2% and acrylic acid
Or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymer 0.05%~0.35%；
B component: deionized water 45%~66%, dipotassium glycyrrhizinate 0.05%~0.2%, disodium ethylene diamine tetraacetate
0.05%~0.15% and xanthan gum 0.05~0.25%；
Component C: methylparaben 0.05%~0.25% and propylene glycol 1%~6%；
D component: dimethyl silicone polymer 1%~5%, Butyrospermum parkii fruit rouge 0.5%~3.5%, Trivent OCG and/
Or Triglyceride DDD 2%~5%, Queensland nut seed oil 0.5%~4%, coconut oil last of the ten Heavenly stems ester 1%~4%, tocopherol acetate
0.01%~0.05%, cetostearyl alcohol 1%~3%, propylben 0.1%~0.3%, ceteareth -6 1%
~5% and PEG-60 rilanit special 1.5%~6%；
Component E: deionized water 2%~5% and aminomethyl propanol 0.03%~0.25%；
F component: sodium acrylate and/or sodium acryloyldimethyl taurate copolymers 0.5%~2.5%；
G component: Phenoxyethanol 0.3%~0.9% and the skin matrix 5%~20%.
In the moisturizing cream that the preferred embodiment for the present invention provides, component A, B component, component C, D component, component E, F group
Point and the percentage composition of each raw material in G component calculated on the basis of the weight of entire skin care cream.
In component A, the typical but non-limiting percentage composition of 1,3-BDO for example can be with are as follows: 2%, 3%, 4%, 5%,
6%, 7% or 8%；The typical but non-limiting percentage composition of glycerol for example can be with are as follows: 1%, 2%, 3%, 4%, 5% or 6%；
The typical but non-limiting percentage composition of Sodium Hyaluronate for example can be with are as follows: 0.02%, 0.04%, 0.06%, 0.08%,
0.1%, 0.12%, 0.14%, 0.16%, 0.18% or 0.2%；Acrylic acid or acrylic ester or C10-C30 alkylol acrylamide acid esters
The typical but non-limiting percentage composition of cross-linked polymer for example can be with are as follows: 0.05%, 0.1%, 0.15%, 0.2%,
0.25%, 0.3% or 0.35%.
In B component, the typical but non-limiting percentage composition of deionized water for example can be with are as follows: 45%, 47%, 50%,
52%, 54%, 56%, 58%, 60%, 62%, 64% or 66%；The typical but non-limiting percentage composition example of dipotassium glycyrrhizinate
It such as can be with are as follows: 0.05%, 0.1%, 0.15% or 0.2%；The typical but non-limiting percentage composition of disodium ethylene diamine tetraacetate
It such as can be with are as follows: 0.05%, 0.07%, 0.09%, 0.1%, 0.12% or 0.15%；Xanthan gum typical but non-limiting hundred
Point content for example can be with are as follows: 0.05%, 0.1%, 0.15% or 0.25%.
In component C, the typical but non-limiting percentage composition of methylparaben for example can be with are as follows: 0.05%, 0.1%,
0.15% or 0.25%；The typical but non-limiting percentage composition of propylene glycol for example can be with are as follows: 1%, 2%, 3%, 4%, 5% or
6%.
In D component, the typical but non-limiting percentage composition of dimethyl silicone polymer for example can be with are as follows: 1%, 2%, 3%,
4% or 5%；The typical but non-limiting percentage composition of Butyrospermum parkii fruit rouge for example can be with are as follows: 0.5%, 1%, 1.5%, 2%,
2.5%, 3% or 3.5%；Trivent OCG and/or the typical but non-limiting percentage composition of Triglyceride DDD for example may be used
With are as follows: 2%, 3%, 4% or 5%；The typical but non-limiting percentage composition of Queensland nut seed oil for example can be with are as follows: 0.5%,
1%, 2%, 3% or 4%；The typical but non-limiting percentage composition of coconut oil last of the ten Heavenly stems ester for example can be with are as follows: 1%, 2%, 3% or
4%；The typical but non-limiting percentage composition of tocopherol acetate for example can be with are as follows: 0.01%, 0.02%, 0.03%,
0.04% or 0.05%；The typical but non-limiting percentage composition of cetostearyl alcohol for example can be with are as follows: 1%, 1.5%, 2%,
2.5% or 3%；The typical but non-limiting percentage composition of propylben for example can be with are as follows: 0.1%, 0.15%, 0.2%,
0.25% or 0.3%；The typical but non-limiting percentage composition of ceteareth -6 for example can be with are as follows: 1%, 2%, 3%,
4% or 5%；The typical but non-limiting percentage composition of PEG-60 rilanit special for example can be with are as follows: 1.5%, 2%, 3%,
4%, 5% or 6%.
In component E, the typical but non-limiting percentage composition of deionized water for example can be with are as follows: 2%, 3%, 4% or 5%；
The typical but non-limiting percentage composition of aminomethyl propanol for example can be with are as follows: 0.03%, 0.05%, 0.1%, 0.15%, 0.2%
Or 0.25%.
In F component, sodium acrylate and/or the typical but non-limiting percentage of sodium acryloyldimethyl taurate copolymers contain
Amount for example can be with are as follows: 0.5%, 1%, 1.5%, 2% or 2.5%.
Below in conjunction with embodiment and comparative example, the present invention will be further described in detail.
Examples 1 to 5 and comparative example 1~6 each provide a kind of skin matrix, and Examples 1 to 5 and comparative example 1
~6 skin matrixes provided are all made of identical preparation method and are prepared, and the concrete composition of each embodiment and comparative example is listed in
Table 1.
The preparation method of Examples 1 to 5 and the skin matrix in comparative example 1~6 the following steps are included:
S1: modified Schizophyllum commune Fr polysaccharides being added in deionized water, 90 DEG C is heated to and stirs, mixing speed 800r/min,
Cooling water temperature is opened to 45 DEG C after keeping the temperature 20min；
S2: 1,3 butylene glycol, Antarctic Continent clump stalk algae extract, chicory root extract and Phenoxyethanol are added what S1 was obtained
It in solution, stirs evenly, the mixing speed during being somebody's turn to do is 600r/min, mixing time 15min；
S3: with 200 mesh filter-cloth filterings to get skin matrix.
The skin matrix of 1 Examples 1 to 5 of table and comparative example 1~6 at being grouped as
It should be pointed out that the modification Schizophyllum commune Fr polysaccharides in Examples 1 to 5 and comparative example 1~6 are all made of following methods system
It is standby to obtain, specifically includes the following steps:
S1. Schizophyllum commune Fr polysaccharides fermentation liquid is centrifuged to obtain supernatant, it is 0.75% that supernatant, which is concentrated as mass fraction of polysaccharide,
Concentrate；
S2. Schizophyllum commune Fr polysaccharides concentrate obtained by S1. is placed in constant temperature water bath, using probe type ultrasonic wave producer pair
It carries out ultrasonotomography processing, and ultrasonic power 600W, ultrasonic time 60min, being ultrasonically treated temperature in whole process is 40 DEG C；
S3. 95% ethyl alcohol is added into S2. treated polysaccharide solution, makes ethyl alcohol final concentration of 62% in solution, 4 DEG C of alcohol
Precipitating freeze-drying is obtained the modified Schizophyllum commune Fr polysaccharides by heavy 12h.
Embodiment 6
The present embodiment is a kind of Essence, including following components in percentage by weight:
Component A: deionized water 55%, acrylic acid 0.15%, dipotassium glycyrrhizinate 0.05% and disodium ethylene diamine tetraacetate
0.1%；
B component: 1,3 butylene glycol 8% and Sodium Hyaluronate 0.1%；
Component C: propylene glycol 3% and Phenoxyethanol 0.5%；
D component: aminomethyl propanol 0.1% and deionized water 3%；
Component E: the skin matrix 30% that embodiment 1 provides.
Wherein, the preparation method of the Essence in the present embodiment, comprising the following steps:
Step a): the Sodium Hyaluronate in B component is added in 1,3-BDO, and stirring is pre-dispersed, obtains preformed solution I,
It is spare；
Step b): successively by the deionized water and acrylic acid addition water phase pot in component A, stirring heating is reached to temperature
Preformed solution I, dipotassium glycyrrhizinate and disodium ethylene diamine tetraacetate are added after to 70 DEG C, is continuously heating to 85 DEG C, opens homogeneous
2min is kept the temperature spare；Mixing speed during this is 700r/min, soaking time 20min, homogeneous speed 3000r/min；
Step c): the Phenoxyethanol in component C being added in propylene glycol, stirs evenly, obtains preformed solution II, spare；
Step d): the aminomethyl propanol in D component is added in deionized water, is stirred to state is completely dissolved, is obtained prefabricated
Solution III, it is spare；
Step e): it in step b) after the insulating process of homogeneous, opens cooling water and cooling is stirred to water phase pot raw material, stir
Speed 500r/min is mixed, when being cooled to 50 DEG C, preformed solution II, preformed solution III and component E is added, continues to stir 15min, stir
It mixes and crosses 200 mesh filter clothes uniformly to get the Essence containing the skin matrix.
Embodiment 7
The present embodiment is a kind of Essence, compared with Example 6, the shield of the offer of embodiment 2 is used in this embodiment
Skin matrix, other compositions and preparation method are same as Example 6.
Embodiment 8
The present embodiment is a kind of Essence, compared with Example 6, the shield of the offer of embodiment 3 is used in this embodiment
Skin matrix, other compositions and preparation method are same as Example 6.
Embodiment 9
The present embodiment is a kind of Essence, compared with Example 6, the shield of the offer of embodiment 4 is used in this embodiment
Skin matrix, other compositions and preparation method are same as Example 6.
Embodiment 10
The present embodiment is a kind of Essence, compared with Example 6, the shield of the offer of embodiment 5 is used in this embodiment
Skin matrix, other compositions and preparation method are same as Example 6.
Embodiment 11
The present embodiment is a kind of Essence, including following components in percentage by weight:
Component A: deionized water 50%, acrylic acid 0.2%, dipotassium glycyrrhizinate 0.15% and disodium ethylene diamine tetraacetate
0.05%；
B component: 1,3 butylene glycol 12% and Sodium Hyaluronate 0.15%；
Component C: propylene glycol 1% and Phenoxyethanol 1%；
D component: aminomethyl propanol 0.05% and deionized water 2%；
Component E: the skin matrix 33% that embodiment 1 provides.
The preparation method of Essence in the present embodiment is same as Example 6.
Embodiment 12
The present embodiment is a kind of Essence, including following components in percentage by weight:
Component A: deionized water 65%, acrylic acid 0.05%, dipotassium glycyrrhizinate 0.05% and disodium ethylene diamine tetraacetate
0.08%；
B component: 1,3 butylene glycol 15% and Sodium Hyaluronate 0.2%；
Component C: propylene glycol 2% and Phenoxyethanol 0.8%；
D component: aminomethyl propanol 0.12% and deionized water 1%；
Component E: the skin matrix 16% that embodiment 1 provides.
The preparation method of Essence in the present embodiment is same as Example 6.
Comparative example 7
This comparative example is a kind of Essence, is the shield that comparative example 1 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Comparative example 8
This comparative example is a kind of Essence, is the shield that comparative example 2 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Comparative example 9
This comparative example is a kind of Essence, is the shield that comparative example 3 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Comparative example 10
This comparative example is a kind of Essence, is the shield that comparative example 4 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Comparative example 11
This comparative example is a kind of Essence, is the shield that comparative example 5 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Comparative example 12
This comparative example is a kind of Essence, is the shield that comparative example 6 provides compared with Example 6, used in this comparative example
Skin matrix, other compositions and preparation method are same as Example 6.
Embodiment 13
The present embodiment is a kind of face cream, including following components in percentage by weight:
Component A: 1,3 butylene glycol 5.5%, glycerol 3.6%, Sodium Hyaluronate 0.05% and acrylic acid 0.23%；
B component: deionized water 46%, dipotassium glycyrrhizinate 0.05%, disodium ethylene diamine tetraacetate 0.1% and xanthan gum
0.15%；
Component C: methylparaben 0.1% and propylene glycol 2%；
D component: dimethyl silicone polymer 3.5%, Butyrospermum parkii fruit rouge 2.5%, caprylic/capric triglyceride 4%, Australia
Nut seed oil 2.5%, coconut oil last of the ten Heavenly stems ester 1.5%, tocopherol acetate 0.05%, cetostearyl alcohol 2%, propylben
0.2%, ceteareth -6 3% and PEG-60 rilanit special 4%；
Component E: deionized water 2% and aminomethyl propanol 0.17%；
F component: sodium acrylate/sodium acryloyldimethyl taurate copolymers 1.2%；
G component: the skin matrix 15% of Phenoxyethanol 0.6% and the offer of embodiment 1.
The specific preparation method of face cream in the present embodiment includes the following steps:
Step a): by the Sodium Hyaluronate and acrylic acid addition 1,3-BDO and glycerol in component A, being dispersed with stirring,
Obtain preformed solution I；
Step b): the methylparaben in component C is added in propylene glycol, 60 DEG C is heated with stirring to being completely dissolved, obtains
Preformed solution II；
Step c): the aminomethyl propanol in component E is added in deionized water, is stirred to being completely dissolved, is obtained preformed solution
ⅲ；
Step d): by B component deionized water and xanthan gum sequentially add water phase pot, when agitating and heating is warming up to 70 DEG C
Dipotassium glycyrrhizinate, EDTA-2Na, preformed solution I and preformed solution II is added, continues stirring and is warming up to 90 DEG C, heat preservation is spare, obtains
Aqueous Phase Raw Material；800~1000r/min of mixing speed during this, 15~20min of soaking time；
Step e): by dimethyl silicone polymer, the Butyrospermum parkii fruit rouge, caprylic/capric triglyceride, Australia in D component
Nut seed oil, coconut oil last of the ten Heavenly stems ester, tocopherol acetate, cetostearyl alcohol, propylben, ceteareth -6 and PEG-
60 rilanit specials sequentially add oily phase pot, and agitating and heating is warming up to 85 DEG C, and heat preservation is spare, obtains oily phase raw material；During this
600~800r/min of mixing speed, 10~15min of soaking time；
Step f): Aqueous Phase Raw Material is added in emulsifier unit, high-speed stirred is opened, under the conditions of 85~90 DEG C, by oily phase
Raw material is slowly added in emulsifier unit, obtains mixed liquor, and mixed liquor is then carried out high speed homogenization；Mixing speed during this
800~1000r/min, homogeneous 2000~3000r/min of speed, homogenizing time 3min；
Step g): after the completion of homogeneous, it is constant to be kept stirring speed, and preformed solution III is added when being cooled to 70~75 DEG C, opens
Homogeneous 2min is opened, sodium acrylate/sodium acryloyldimethyl taurate copolymers are then added, homogeneous 2min is opened, is kept stirring
Speed is constant, opens cooling water and continues to cool down；1500~2500r/min of homogeneous speed during this；
Step h): G component is added when being cooled to 45~55 DEG C, with the mixing speed mixing time of 600~800r/min
15min crosses 200 meshes after mixing evenly to get skin lotion.
Embodiment 14
The present embodiment is a kind of skin lotion, and compared with embodiment 13, the shield of the offer of embodiment 2 is used in this embodiment
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Embodiment 15
The present embodiment is a kind of skin lotion, and compared with embodiment 13, the shield of the offer of embodiment 3 is used in this embodiment
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Embodiment 16
The present embodiment is a kind of skin lotion, and compared with embodiment 13, the shield of the offer of embodiment 4 is used in this embodiment
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Embodiment 17
The present embodiment is a kind of skin lotion, and compared with embodiment 13, the shield of the offer of embodiment 5 is used in this embodiment
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Embodiment 18
The present embodiment is a kind of skin lotion, including following components in percentage by weight:
Component A: 1,3 butylene glycol 2%, glycerol 4.5%, Sodium Hyaluronate 0.1% and acrylic acid 0.3%；
B component: deionized water 48%, dipotassium glycyrrhizinate 0.1%, disodium ethylene diamine tetraacetate 0.12% and xanthan gum
0.18%；
Component C: methylparaben 0.2% and propylene glycol 3.5%；
D component: dimethyl silicone polymer 1%, Butyrospermum parkii fruit rouge 1%, caprylic/capric triglyceride 2.2%, Australia are hard
Fruit seed oil 3%, coconut oil last of the ten Heavenly stems ester 3%, tocopherol acetate 0.02%, cetostearyl alcohol 1%, propylben 0.13%, whale
Wax stereth -6 2% and PEG-60 rilanit special 5%；
Component E: deionized water 3.75% and aminomethyl propanol 0.1%；
F component: sodium acrylate/sodium acryloyldimethyl taurate copolymers 0.5%；
G component: the skin matrix 18% of Phenoxyethanol 0.3% and the offer of embodiment 1.
The preparation method of skin lotion in the present embodiment is identical as embodiment 13.
Embodiment 19
The present embodiment is a kind of skin lotion, including following components in percentage by weight:
Component A: 1,3 butylene glycol 8%, glycerol 1.7%, Sodium Hyaluronate 0.17% and acrylic acid 0.07%；
B component: deionized water 53%, dipotassium glycyrrhizinate 0.12%, disodium ethylene diamine tetraacetate 0.05% and xanthan gum
0.1%；
Component C: methylparaben 0.15% and propylene glycol 3%；
D component: dimethyl silicone polymer 5%, Butyrospermum parkii fruit rouge 3.5%, caprylic/capric triglyceride 2%, Australia are hard
Fruit seed oil 1%, coconut oil last of the ten Heavenly stems ester 2%, tocopherol acetate 0.04%, cetostearyl alcohol 2.5%, propylben 0.2%, whale
Wax stereth -6 3% and PEG-60 rilanit special 1.5%；
Component E: deionized water 2% and aminomethyl propanol 0.2%；
F component: sodium acrylate/sodium acryloyldimethyl taurate copolymers 2%；
G component: the skin matrix 8% of Phenoxyethanol 0.7% and the offer of embodiment 1.
The preparation method of skin lotion in the present embodiment is identical as embodiment 13.
Comparative example 13
This comparative example is a kind of skin lotion, is the shield that comparative example 1 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Comparative example 14
This comparative example is a kind of skin lotion, is the shield that comparative example 2 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Comparative example 15
This comparative example is a kind of skin lotion, is the shield that comparative example 3 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Comparative example 16
This comparative example is a kind of skin lotion, is the shield that comparative example 4 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Comparative example 17
This comparative example is a kind of skin lotion, is the shield that comparative example 5 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Comparative example 18
This comparative example is a kind of skin lotion, is the shield that comparative example 6 provides compared with embodiment 13, used in this comparative example
Skin matrix, other compositions and preparation method are identical as embodiment 13.
Efficacy validation test
1, anti-light aging confirmatory experiment
The skin matrix that the embodiment of the present invention 1~5 and comparative example 1~6 provide is tested using elastoser Inhibition test
Anti-light aging effect.
(1) experimental principle
Elastomer is made of elastin laminin and microfibril, is distributed in corium and subcutaneous tissue, and skin is made to have elasticity.
And due to the effect of the environmental factors such as ultraviolet light irradiation, the generation of internal elastoser can be promoted.Elastoser is that pancreas is solidifying
A member in galactase family, can degrade elastin laminin, cause the forfeiture for connecting tissue in epidermis, decline so as to cause skin
Always, the generation of wrinkle and light aging.
(2) experiment reagent
Tris-HCl buffer, N- methoxyl group succinyl-Ala-Pro-Val -4- nitroaniline
(MAAPVN), elastoser and catechin and gallate.
(3) tested material
Skin matrix in Example 1~5 and comparative example 1~6 respectively, is diluted to various concentration and is tested, to go
Ionized water is blank control.
(4) experimental procedure
By the Tris-HCl buffer of the 0.2mol/L of 100 μ L, the MAAPVN of the 10mmol/L of 25 μ L and 50 μ L's is tested
Object mixes, and is incubated for 15min under the conditions of 25 DEG C；Then the elastoser (active highest) that the 0.3U/mL of 25 μ L is added continues
It is incubated for 15min.Microplate reader detects OD value under the conditions of 410nm, and is calculated by the following formula inhibiting rate:
Test result is listed in table 2.
2 skin matrix of table is to elastoser inhibition assay result
Experimental result is as shown in table 2, it can be seen that as concentration increases, inhibiting effect of each sample to elastoser
It gradually rises；Under identical mass concentration, the skin matrix in Examples 1 to 5, especially embodiment 1 and embodiment 2 is for elasticity
The inhibiting effect of protease will be significantly higher than the sample in comparative example 1~6.Experimental result illustrates skin care base according to the present invention
Matter has good anti-light aging effect.
2, moistening effect confirmatory experiment
Each sample moisturizing is carried out according to light industry professional standard QB/T 4256-2011 cosmetics moisture-keeping efficacy evaluation guide
The measurement of effect.
(1) preparation of tested material
First group of test specimen: 30% mass point is diluted to the skin matrix in Examples 1 to 5 and comparative example 1~6
Several aqueous solutions are measured；
Second group of test specimen: it is measured with the Essence stoste that embodiment 6-12 and comparative example 7-12 is provided；
Third group test specimen: it is measured with the Essence stoste that embodiment 13-19 and comparative example 13-18 is provided.
(2) test method
Healthy volunteer 30, male 15, women 15, the age 20~40 years old, healthy volunteer is divided into 3 groups, often
Group each 5 people of men and women, is tested with first group to third group test specimen respectively.In isoperibol (22 ± 1 DEG C), relative humidity
After 50 ± 5%, rest 1h.Subject's left hand inner forearm (4cm × 4cm) is applied to according to the dosage of (2.0 ± 0.1) mg/cm2
With (4cm × 4cm) on the inside of right forearm, blank control (not applying) while testing.Respectively be painted with sample 0.5h, 1.0h, 2.0h,
The hydrauture state of skin is tested after 4.0h, 8.0h.The moistening effect test result of skin matrix is listed in table 3, the guarantor of Essence
Wet measure of merit result is listed in table 4, and the moistening effect test result of skin lotion is listed in table 5.
The moistening effect measurement result of 3 skin matrix of table
It is can be seen that by the experimental result of table 3 with the extension of time, hydrauture gradually decreases, but embodiment 1~
Skin matrix moistening effect in 5, especially embodiment 1 and embodiment 2 is significantly higher than the skin matrix in comparative example 1~6.It is real
It applies the hydrauture of the skin matrix in example 1 and embodiment 2 after 8 hours and is higher by 60% or more than comparative example 1~6, illustrate this
The skin matrix provided is invented, other than with preferable initial stage moistening effect, it is often more important that the moistening effect in later period is more
Add significant.Each component in raw material can make skin matrix have preferable moistening effect, missing or reduction by synergistic effect
Any component or the content of feed change can impact the moistening effect of skin matrix, wherein missing is reduced
The moistening effect of the skin matrix of the comparative example 1 and comparative example 2 of modified Schizophyllum commune Fr polysaccharides is worst.
4 embodiment of table and the comparison of comparative example Essence moistening effect
It is can be seen that by the experimental result of table 4 with the extension of time, hydrauture gradually decreases, but embodiment 6~
Essence moistening effect in 12, especially embodiment 6 and embodiment 7 is significantly higher than the Essence in comparative example 7~12.Implement
The hydrauture of Essence after 8 hours in example 6 and embodiment 7 is higher by 60% or more than comparative example 7~12, illustrates the present invention
The Essence of offer, other than with preferable initial stage moistening effect, it is often more important that the moistening effect in later period is more significant.
Each component in raw material can make Essence have preferable moistening effect, missing or reduction are any by synergistic effect
Component or the content of feed change can affect greatly the moistening effect of Essence.
5 embodiment of table and the comparison of comparative example cold cream moistening effect
It is can be seen that by the experimental result of table 5 with the extension of time, hydrauture gradually decreases, but embodiment 13
Cold cream moistening effect in~19, especially embodiment 13 and embodiment 14 is significantly higher than the skin care in comparative example 13~18
Cream.The hydrauture of cold cream after 8 hours in embodiment 13 and embodiment 14 is maintained at 50% or more, and comparative example 13~18
In cold cream hydrauture after 8 hours keep 40% hereinafter, illustrating Essence provided by the invention, in addition to having
Except preferable initial stage moistening effect, it is often more important that the moistening effect in later period is more significant.Each component in raw material passes through association
Same effect can make cold cream have preferable moistening effect, missing or the content for reducing any component or feed change
The moistening effect of cold cream can be affected greatly.
Above-mentioned experimental result illustrates that skin matrix provided by the present invention has good moistening effect, adds it to essence
In magnificent liquid and cream, good moisture-retaining capacity can be provided for product.
3, maintenance compliance test result is tested
(1) tested crowd
Skin of face suffers from the women of ulcer between 50 25~35 one full year of life.
(2) subject method
The skin matrix prepared in each embodiment and comparative example, Essence and cream are tried out in face, is smeared daily twice,
Persistently using after four weeks, the maintenance effect of skin is examined or check.
(3) judgment criteria
Significant obviously to decline for supervisor's symptom, keloid flattens, soft and normal skin is close, flush decline；Effectively
For subjective symptom mitigation, keloid is compared to flatten and soft originally；It is general effectively to decline for flush, no hair trend；In vain
Unobvious for subjective symptom mitigation, keloid is without significant change or is aggravated.The calculation formula of total effective rate are as follows:
Evaluation result is listed in table 6.
6 maintenance experiment results of table
As known from Table 6, embodiment 1-5 and the desalination scar total effective rate using its Essence and skin lotion that are prepared
75% or more, and comparative example 1-6 and equal using the desalination scar total effective rate of its Essence and skin lotion that are prepared
Below 50%.Each component in raw material can make Essence and skin lotion have preferable moistening effect by synergistic effect,
Missing or any component of reduction or the content of feed change can be obviously reduced the maintenance ability of product, are especially missing from and change
The skin matrix of property Schizophyllum commune Fr polysaccharides and its skin repair ability of cosmetics are worst.Experiment show is of the invention
Skin matrix has good skin repair ability, can be applied in the skin-protection product of corresponding effect.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (23)
1. a kind of skin matrix, which is characterized in that by weight percentage include following components: deionized water 65%~75%,
Modified Schizophyllum commune Fr polysaccharides 0.5%~1.8%, 1,3 butylene glycol 10%~30%, Phenoxyethanol 0.4%~0.5%, Antarctic Continent clump
Obstruct algae extract 2%~4% and chicory root extract 2.5%~4%.
2. skin matrix according to claim 1, which is characterized in that the modified Schizophyllum commune Fr polysaccharides use following methods system
Standby to obtain, the method includes the successively concentrated, ultrasonotomography by Schizophyllum commune Fr polysaccharides fermentation liquid, alcohol precipitation and the steps of drying.
3. skin matrix according to claim 2, which is characterized in that it is described concentration include by Schizophyllum commune Fr polysaccharides fermentation liquid from
Then supernatant is concentrated to get the concentrate containing Schizophyllum commune Fr polysaccharides to supernatant by gains in depth of comprehension.
4. skin matrix according to claim 3, which is characterized in that the mass fraction of Schizophyllum commune Fr polysaccharides in the concentrate
It is 0.5%~1%.
5. skin matrix according to claim 2, which is characterized in that the concentration is reduced pressure.
6. skin matrix according to claim 2, which is characterized in that in the ultrasonotomography, ultrasonic device is sonde-type
Supersonic generator, the ultrasonic power 500W~700W, 15~90min of ultrasonic time, ultrasonic temperature≤50 DEG C.
7. skin matrix according to claim 6, which is characterized in that ultrasonic temperature is 30~50 DEG C.
8. skin matrix according to claim 2, which is characterized in that ethanol solution is added after ultrasonotomography and carries out at alcohol precipitation
Reason.
9. skin matrix according to claim 8, which is characterized in that second in the mixing liquid obtained after ethanol solution is added
Determining alcohol be 60%~65%, 3~6 DEG C of alcohol precipitation temperature, 11~14h of alcohol precipitation time.
10. skin matrix according to claim 8, which is characterized in that the volume fraction of the ethanol solution of addition be 92~
96%.
11. skin matrix according to claim 2, which is characterized in that the drying mode is freeze-drying.
12. skin matrix according to claim 2, which is characterized in that the molecular weight of the modification Schizophyllum commune Fr polysaccharides after dry
It is 1 × 105Da~2 × 106Da。
13. a kind of preparation method of the described in any item skin matrixes of claim 1-12, which is characterized in that split including that will be modified
Gill fungus polysaccharide, 1,3 butylene glycol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract are dissolved in deionized water
Step.
14. the preparation method of skin matrix according to claim 13, which is characterized in that it is molten will to be first modified Schizophyllum commune Fr polysaccharides
In deionized water, adds 1,3-BDO, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract and stir
Uniformly, the skin matrix is obtained.
15. preparation method according to claim 14, which is characterized in that modified Schizophyllum commune Fr polysaccharides are dissolved in deionized water
In, it is stirred under the conditions of 85~90 DEG C, after keeping the temperature 20~60min, is cooled to 40~50 DEG C, then adds 1,3- fourth
Glycol, Phenoxyethanol, Antarctic Continent clump stalk algae extract and chicory root extract simultaneously stir evenly, and the skin care base is obtained by filtration
Matter.
16. preparation method according to claim 15, which is characterized in that the mixing speed is 400~800r/min.
17. preparation method according to claim 15, which is characterized in that mentioned in addition Phenoxyethanol, Antarctic Continent clump stalk algae
It takes object and chicory root extract and is filtered processing again after mixing evenly, obtain the skin matrix.
18. preparation method according to claim 15, which is characterized in that mesh number when filtering is 150~250 mesh.
19. a kind of described in any item skin matrixes of claim 1~12 are preparing the purposes in cosmetics.
20. a kind of cosmetics, which is characterized in that including the described in any item skin matrixes of claim 1-12.
21. cosmetics according to claim 20, which is characterized in that by weight percentage include 1%~40% shield
Skin matrix.
22. the cosmetics according to claim 20 or 21, which is characterized in that the cosmetics are Essence, the essence
Liquid includes following components in percentage by weight:
Component A: deionized water 40%~75%, acrylic acid or acrylic ester or C10-C30 alkylol acrylamide acid esters cross-linked polymer
0.05%~0.2%, dipotassium glycyrrhizinate 0.05%~0.15% and disodium ethylene diamine tetraacetate 0.05%~0.1%；
B component: 1,3 butylene glycol 5%~15% and Sodium Hyaluronate 0.01%~0.3%；
Component C: propylene glycol 1%~3% and Phenoxyethanol 0.3%~1%；
D component: aminomethyl propanol 0.03%~0.14% and deionized water 1%~3%；
Component E: the skin matrix 1%~35%.
23. the cosmetics according to claim 20 or 21, which is characterized in that the cosmetics are moisturizing cream, the profit
Skin cream includes following components in percentage by weight:
Component A: 1,3 butylene glycol 2%~8%, glycerol 1%~6%, Sodium Hyaluronate 0.02%~0.2% and acrylic acid or third
Enester or C10-C30 alkylol acrylamide acid esters cross-linked polymer 0.05%~0.35%；
B component: deionized water 45%~66%, dipotassium glycyrrhizinate 0.05%~0.2%, disodium ethylene diamine tetraacetate 0.05%~
0.15% and xanthan gum 0.05~0.25%；
Component C: methylparaben 0.05%~0.25% and propylene glycol 1%~6%；
D component: dimethyl silicone polymer 1%~5%, Butyrospermum parkii fruit rouge 0.5%~3.5%, Trivent OCG and/or the last of the ten Heavenly stems
Acid glycerol three ester 2%~5%, Queensland nut seed oil 0.5%~4%, coconut oil last of the ten Heavenly stems ester 1%~4%, tocopherol acetate
0.01%~0.05%, cetostearyl alcohol 1%~3%, propylben 0.1%~0.3%, ceteareth -6 1%
~5% and PEG-60 rilanit special 1.5%~6%；
Component E: deionized water 2%~5% and aminomethyl propanol 0.03%~0.25%；
F component: sodium acrylate and/or sodium acryloyldimethyl taurate copolymers 0.5%~2.5%；
G component: Phenoxyethanol 0.3%~0.9% and the skin matrix 5%~20%.
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| CN108354857A (en) * | 2018-04-08 | 2018-08-03 | 大连军门保健食品有限公司 | Water beautifying liquid and preparation method thereof is refined after a kind of extraction of witloof polysaccharide |
| CN108434086A (en) * | 2018-04-25 | 2018-08-24 | 广州赛莱拉干细胞科技股份有限公司 | Composition and its cosmetics containing Antarctic Continent clump stalk algae extract |
| CN109172431A (en) * | 2018-09-10 | 2019-01-11 | 广州丽彦妆生物科技有限公司 | A kind of hormone face repairs desensitization egg white icing and preparation method thereof |
| CN109077952B (en) * | 2018-10-29 | 2020-08-07 | 广州市科能化妆品科研有限公司 | Blue-light-resistant air cushion CC cream and preparation method thereof |
| CN110433113A (en) * | 2019-08-12 | 2019-11-12 | 天津市康婷生物工程集团有限公司 | A kind of essence dew and preparation method containing the anti-ageing composition of moisturizing |
| CN111265443A (en) * | 2020-03-20 | 2020-06-12 | 西北师范大学白银师科创新研究院 | Anti-aging essence skin care lotion containing codonopsis pilosula extract and preparation method of anti-aging essence skin care lotion |
| CN112315846B (en) * | 2020-10-30 | 2023-08-25 | 广东丸美生物技术股份有限公司 | Schizophyllum commune polysaccharide liposome and preparation method and application thereof |
| CN113230162A (en) * | 2021-05-27 | 2021-08-10 | 天芮(中国)化妆品有限公司 | Composite essence with anti-aging and repairing functions and processing technology thereof |
| CN113476383A (en) * | 2021-07-26 | 2021-10-08 | 南京苗邦美业企业管理有限公司 | Soothing, repairing and moisturizing mask composition containing various plant essences |
| CN114306125B (en) * | 2021-12-27 | 2023-01-13 | 广东丸美生物技术股份有限公司 | Composition containing schizophyllan with different molecular weights as well as preparation method and application thereof |
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| CN101580557B (en) * | 2009-06-16 | 2011-08-17 | 鞍山中兴医药集团有限公司 | Preparation process for extracting inulin from cichory root |
| CN101643759B (en) * | 2009-07-31 | 2012-02-01 | 中国农业科学院农产品加工研究所 | Method for preparing Schizophyllum commune Fr polysaccharides and dedicated culture medium thereof |
| CN105411991B (en) * | 2016-01-08 | 2019-01-29 | 青岛康尔生物工程有限公司 | It is a kind of based on deep layer maintenance, the skin spray of long-acting moisturizing and preparation method thereof |
| CN110151625A (en) * | 2016-08-24 | 2019-08-23 | 田中荣 | A kind of cosmetic composition with moisturizing maintenance effect suitable for whole skin |
| CN107007525A (en) * | 2017-04-28 | 2017-08-04 | 珠海伊斯佳科技股份有限公司 | A kind of composition with long-lasting moisturization and applied in cosmetics |
| CN107266400B (en) * | 2017-07-26 | 2020-09-08 | 新疆正生农业资源开发研究院（有限公司） | Method for extracting lactuca sativa bitter principle from chicory |
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