CN111265443A - Anti-aging essence skin care lotion containing codonopsis pilosula extract and preparation method of anti-aging essence skin care lotion - Google Patents
Anti-aging essence skin care lotion containing codonopsis pilosula extract and preparation method of anti-aging essence skin care lotion Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Abstract
The invention discloses an anti-aging essence skin moisturizer of a codonopsis pilosula extract, which is prepared from the following raw materials: radix Codonopsis extract water soluble extract, natural polysaccharide modified attapulgite, taurine, hyaluronic acid, and ultrapure water; and provides a preparation method thereof. The invention has the beneficial effects that: the invention completely reserves the natural effective component proportion of the codonopsis pilosula, does not contain any ester component, and ensures the breathing smoothness of the skin; the product of the invention has unique texture, moist skin feel, refreshing and no stickiness, can be used for daily skin care, and has the effects of moisturizing, resisting inflammation, relieving, resisting aging and brightening skin; the invention does not add any preservative, and is a completely friendly skin care product; compared with the prior high-grade commercially available essence, the anti-aging essence disclosed by the invention is better in permeability, moisture retention and anti-aging property and easier to absorb; the preparation method disclosed by the invention is simple in process, low in cost and easy to construct a processing production line, and provides favorable conditions for popularization and application of the anti-aging essence.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine cosmetics, and in particular relates to a codonopsis pilosula extract anti-aging essence skin care lotion and a preparation method thereof.
Background
The radix Codonopsis is dried root of radix Codonopsis, radix Codonopsis Lanceolatae or radix Codonopsis Pilosulae belonging to Campanulaceae family. Radix Codonopsis is a traditional Chinese tonic drug with sweet and mild properties and flavor, and enters spleen and lung meridians. The main effects are strengthening spleen, benefiting lung, nourishing blood and promoting the production of body fluid. The name of the codonopsis pilosula is recorded in Ben Cao Yuan Xin of Wu Yiluo in Qing Dynasty, later in Ben Cao gang mu Shi and plant famous and realty charts, but the medicine is supplied before the Qing Dynasty, namely, the codonopsis pilosula in the Campanulaceae of Taihang mountain is utilized and the codonopsis pilosula in the Taihang mountain is distinguished from the Ben Cao Yuan Xin in the Ben Cao Xin.
According to the published data, the codonopsis pilosula is mainly used for enhancing the immunity of the organism, resisting oxidation and stress, regulating intestinal flora, resisting mutation, enriching the blood, resisting fatigue, promoting blood coagulation, increasing blood sugar, protecting heart and brain and the like, and has the effects of resisting aging, scavenging free radicals, resisting oxidation and the like. It is used for treating spleen and lung deficiency, deficiency of both qi and blood, asthenia, chronic diarrhea or proctoptosis, and for treating iron deficiency and nutritional anemia. The compound radix Codonopsis tablet is prepared from radix Codonopsis, Saviae Miltiorrhizae radix and radix tinosporae, has effects of promoting blood circulation for removing blood stasis, invigorating qi and calming heart, and can be used for treating coronary heart disease, angina pectoris and chest distress caused by myocardial ischemia.
The codonopsis pilosula is wide in production area in China, but rare codonopsis pilosula is produced in a small number of production areas, especially the wendang and the white-striped dang produced in Gansu province, and is mainly used for preparing traditional Chinese medicines.
With the improvement of living standard of people, the protection of the skin of women is more and more important, and especially, skin care products and color cosmetics which utilize natural components are more popular. Among a plurality of natural skin care products, the Chinese herbal medicine skin care product is more popular. Ancient Chinese people have known the use of natural medicines for internal or external use for beautifying the face for thousands of years, and the ancient books have recorded a lot. It is known that more than 500 Chinese herbal medicines are used in the cosmetics developed at present in China, and the advertisements of the cosmetics are all played as the Wang brand of 'natural essence'. The beauty of the Chinese herbal medicine is unique. It is not a simple makeup or skin care, and teaches an integral beauty treatment, i.e., promoting normal development and metabolism of the whole body and the body surface of the human body, and preventing aging. And the Chinese herbal medicines with the skin care and beauty functions have a plurality of tonic products belonging to tonifying medicines or medicinal and edible sources, and have the advantages of convenient material acquisition and small side effect. In particular, people have been in the beginning to abandon chemical compositions and have advocated natural substances. Therefore, Chinese herbal medicine beauty treatment is popular among people.
The Chinese herbal medicine series skin care products have definite beauty maintaining and young keeping effects; the traditional Chinese medicine is inheritable in history, green, natural, safe and reliable, has clinical application experience of a human body for thousands of years, accumulates a plurality of single products and compound products with unique effects and obvious effects, is derived from nature, is pure normal temperature and mild, has small toxic and side effects, and is safer and more reliable compared with a chemical synthetic product; the Chinese medicinal cosmetics are complete in types and various in dosage forms, almost cover various types of modern cosmetics, are particularly rich and various in dosage forms, and have pertinence to different body parts, different efficacy requirements and different use preferences.
The Chinese herbal medicine containing saccharides, proteins, peptides, amino acids, alkaloids and organic acids has wide beautifying effect, and has the effects of nourishing, repairing, moisturizing, moistening skin, moistening hair, whitening, preventing allergy, resisting aging, inhibiting bacteria, removing freckles and the like. The prior literature reports that the codonopsis pilosula contains a large amount of polysaccharides, codonopsis pilosula glycosides (four types), n-hexyl glucoside, fructosyl glycollic glycoside and the like. Also contains sterol components such as bosterol, stigmasterol; the triterpene components include taraxerol, taraxerol acetate, and friedelin; contains alkaloids such as codonopsis pilosula alkaloid, choline, 5-hydroxy-2-hydroxymethyl pyridine; sesquiterpene lactone component such as atractyloide, 5-hydroxymethyl furfural, and coumarin component such as angelolide, psoralen and succinic acid.
The radix codonopsitis water extract (a product obtained by the traditional water decoction process) can play a role in delaying senility by eliminating excessive free radicals generated by an aging organism and resisting lipid peroxidation; the aqueous extract of radix Codonopsis belongs to strong antioxidant medicine and plays an important role in anti-aging process. The polysaccharide in the water extract can resist the degeneration of immune organs of aging organisms, and can eliminate hydroxyl free radicals and superoxide anions and resist lipid peroxidation to different degrees; the radix codonopsis water extract can delay aging by inhibiting nerve cell apoptosis. In addition, the codonopsis pilosula polysaccharide has immunological activity, can obviously improve lymphocyte proliferation and is in a dose-dependent relationship.
For traditional Chinese medicines, the main components are used for playing the effects, but the synergistic effect of the whole components of the traditional Chinese medicines is also needed for the efficacy, so that the purpose of natural efficacy cannot be achieved by adding a certain main component into cosmetics. In chinese invention patent CN109464342B, an anti-aging essence is disclosed, which comprises the following components by mass percent: 0.01-2% of active peptide, 3-15% of polyalcohol, 0.01-10% of humectant, 0.5-1.2% of plant preservative, 0.1-10% of skin conditioner, 0.02-0.1% of chelating agent, 0.1-2% of anti-inflammatory repairing agent and the balance of deionized water. The invention also provides a preparation method of the anti-aging essence and application of the anti-aging essence in preparation of skin care products. The anti-aging essence disclosed by the invention can be used for daily skin care, has the effects of moisturizing, resisting inflammation, relieving, fading wrinkles and brightening skin color, and meanwhile, the natural plant preservative is adopted, so that the problem of inactivation caused by the compatibility of active peptide and the traditional chemical preservative is solved, and the stability of the product function is ensured. However, the invention does not adopt the combination of the integral components of the natural plants, and the preservative is added, so that the friendliness is still to be improved compared with the product with the preservative added 0. Therefore, the search for safer, milder and more effective skin care essence is not easy.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a codonopsis pilosula extract anti-aging essence skin care lotion and a preparation method thereof. By utilizing modern advanced traditional Chinese medicine extraction technology and combining with the traditional water extraction process of traditional Chinese medicines, the codonopsis pilosula extract is loaded on the surface of the modified attapulgite clay for enhancing the drug effect, and the codonopsis pilosula essence skin moisturizer which has the effects of moisturizing, moistening skin, resisting aging and inhibiting bacteria on skin is prepared.
In order to achieve the purpose, the technical scheme provided by the invention is as follows: the anti-aging essence skin care lotion containing the codonopsis pilosula extract is prepared from the following raw materials in parts by weight: 40 parts of codonopsis pilosula extract water-soluble extract, 5 parts of natural polysaccharide modified attapulgite, 2 parts of taurine, 10 parts of hyaluronic acid and 43 parts of ultrapure water.
Further, the preparation method of the water-soluble extract of the codonopsis pilosula for the anti-aging essence skin care lotion comprises the following steps:
1) cleaning radix Codonopsis, removing silt, drying at 45 deg.C for 24 hr, slicing, and micronizing to D100 no less than 1250 mesh;
2) placing 5kg of radix Codonopsis powder obtained in step 1) in a container, adding 10kg of anhydrous ethanol, refluxing at 80 deg.C for 2 hr, filtering with 0.45 μm microporous membrane to obtain a filtrate, repeating the above operation for 2 times, drying the residue under reduced pressure until ethanol is completely removed, and distilling under reduced pressure at 65 deg.C under-0.1 MPa;
3) adding the dried filter residue into an ultrasonic extractor, adding ultrapure water with the mass of 10 times, performing ultrasonic stirring extraction for 2 hours at 100 ℃, performing ultrasonic power of 60kHz, filtering out a solution through a 0.45-micron microporous filter membrane, repeating the operation for 2 times, and performing ultrasonic extraction and filtration for 3 times in total;
4) combining the filtrates for 3 times, adding a commercially available edible oil decolorizing agent, namely a commercially available modified active attapulgite edible oil decolorizing agent, in an amount of 3% of the total solution mass, stirring for 15 hours at 150-300 r/min to enable the decolorizing agent to fully adsorb pigments in the solution, and then performing filter pressing separation on the decolorizing agent and the aqueous solution by using a 0.45-micron microporous filter membrane at a filter pressing pressure of 0.159 MPa; concentrating the separated water solution to one third of the mass, adding anhydrous ethanol with the mass 10 times of that of the concentrated solution into the concentrated solution, and centrifuging at 3000r/min for 10 minutes after the water-soluble substances are completely precipitated to obtain a crude water-soluble extract; drying at 65 deg.C under reduced pressure of-0.1 MPa for 24 hr to obtain water soluble extract of radix Codonopsis.
Further, the preparation method of the natural polysaccharide modified attapulgite for the codonopsis pilosula extract anti-aging essence skin care lotion comprises the following steps: mixing 10 parts of carrageen crispus extract and 90 parts of commercially available high-purity attapulgite, placing the mixture into a ball mill, carrying out high-speed ball milling for 15 minutes under the condition of 1500r/min, dispersing the mixture into anhydrous ether, heating and stirring the anhydrous ether at 70 ℃ for 18 times of the mass of the attapulgite, stirring the mixture at the rotating speed of 350r/min, removing generated water while reacting until no water is generated, carrying out reduced pressure distillation to remove reaction solvent ether, wherein the reduced pressure distillation condition is 55 ℃, the pressure is-0.1 MPa, and continuously carrying out air suction and vacuum drying at 65 ℃ for 48 hours to completely remove ether, thus obtaining the natural polysaccharide modified attapulgite.
Further, the preparation method of the ultrapure water comprises the following steps: tap water was introduced into a commercially available ultrapure water preparation machine and received from an ultrapure water outlet.
Second of the inventionThe preparation method comprises the steps of mixing 40 parts of codonopsis pilosula extract water-soluble extract, 5 parts of natural polysaccharide modified attapulgite, 2 parts of taurine, 10 parts of hyaluronic acid and 43 parts of ultrapure water, adding the mixture into a high-pressure homogenizer, heating the mixture to 80 ℃ under the high pressure of 300MPa, performing ultrasonic dispersion and assisting mechanical stirring until the mixture is colorless or pale yellow transparent, wherein the ultrasonic power is 120kHz, the stirring speed is 300r/min, and the stirring time is 25 minutes; and then sterilizing and disinfecting by ultraviolet rays to obtain the codonopsis pilosula extract anti-aging essence skin care lotion, wherein the ultraviolet sterilization parameters are as follows: using a particle size of 90. mu.W/cm or more2The ultraviolet lamp is irradiated for not less than 25 seconds.
After the skin moisturizer product is packaged according to 1g, oxygen is completely removed, high-purity nitrogen is filled, the oxygen content is finally lower than 0.001%, and the shelf life of the product can reach more than 1 year.
The innovation points of the invention comprise the following aspects:
1. the combined product of the codonopsis pilosula extract and the attapulgite is not reported in the literature;
2. the application of the codonopsis pilosula and the attapulgite used as cosmetics at the same time is not reported;
3. according to the invention, the codonopsis pilosula extract is decolored through the selective adsorbent, so that the codonopsis pilosula extract is more transparent and more suitable for being applied to skin care products;
4. the invention discovers that natural taurine is added into the product, so that the absorption efficiency of the skin on the codonopsis pilosula extract can be improved, the anti-aging effect is increased, and the process of compounding the codonopsis pilosula and the taurine is not reported;
5. the product of the invention is not added with any preservative, and is completely green and safe.
The invention has the beneficial effects that:
1. the anti-aging essence of the codonopsis pilosula extract completely reserves the natural effective component proportion of the codonopsis pilosula, cannot be achieved by any artificial proportioning, does not contain any ester component, and ensures the breathing smoothness of skin.
2. The product of the invention has unique texture, moist skin feel, refreshing and no stickiness, can be used for daily skin care, and has the effects of moisturizing, resisting inflammation, relieving, resisting aging and brightening skin color.
3. The invention does not add any preservative, namely the preservative 0 is really added, and the invention is a completely friendly skin care product.
4. Compared with the prior high-grade commercially available essence, the anti-aging essence disclosed by the invention has better permeability, moisture retention and anti-aging performance and is easier to absorb.
5. The preparation method disclosed by the invention is simple in process, low in cost and easy to construct a processing production line, and provides necessary conditions for popularization and application of the anti-aging essence.
Detailed Description
The preparation sources used by the invention are as follows:
edible oil fat decolorant (modified active attapulgite): xuyi Ou Bai Teclay materials Limited, OBT-O-2.
Chondrus crispus extract: ningxia Vanilla Biotechnology Ltd, 100-.
High-purity attapulgite: xuyi Ougeobai Teclay materials Ltd, OBT-A-2.
Taurine: shanghai Michelin Biochemical technology Ltd, 107-35-7.
Hyaluronic acid: shanghai Michelin Biochemical technology, Inc., H823435.
Ultrapure water: tap water may be introduced into an ultrapure water preparation machine of commercially available hogfast instruments ltd and received from an ultrapure water outlet.
Example 1:
the anti-aging essence skin care lotion containing the codonopsis pilosula extract is prepared from the following raw materials in parts by weight: 40kg of water-soluble extract of the codonopsis pilosula, 5kg of natural polysaccharide modified attapulgite, 2kg of taurine, 10kg of hyaluronic acid and 43kg of ultrapure water.
The preparation method of the codonopsis pilosula extract water-soluble extract comprises the following steps:
1) cleaning radix Codonopsis, removing silt, drying at 45 deg.C for 24 hr, slicing, and micronizing to D100 no less than 1250 mesh;
2) placing 5kg of radix Codonopsis powder obtained in step 1) in a container, adding 10kg of anhydrous ethanol, refluxing at 80 deg.C for 2 hr, filtering to obtain a filtrate (0.45 μm microporous membrane filtration), repeating the above operation for 2 times, and drying the residue under reduced pressure until ethanol is completely removed (reduced pressure distillation condition: at 65 ℃ and-0.1 MPa);
3) adding the dried filter residue into an ultrasonic extractor, adding ultrapure water with the mass of 10 times, performing ultrasonic stirring extraction at 100 ℃ for 2 hours (ultrasonic power of 60kHz), filtering to obtain a solution (filtering with a 0.45 mu m microporous membrane), repeating the operation for 2 times, and performing ultrasonic extraction and filtration for 3 times in total;
4) mixing the filtrates for 3 times, adding a commercially available edible oil decolorizer (the decolorizer is a commercially available modified active attapulgite edible oil decolorizer) according to the addition amount of 3% of the total solution mass, stirring at 150-300 r/min for 15 hours to enable the decolorizer to fully adsorb pigments in the solution, and then performing filter pressing by using a 0.45-micrometer microporous filter membrane to separate the decolorizer and the aqueous solution (filter pressing at 0.159 MPa); concentrating the separated water solution to one third of the mass, adding anhydrous ethanol (the addition amount of the anhydrous ethanol is 10 times of the mass of the concentrated solution) into the concentrated solution, and after the water-soluble substances are completely precipitated, performing centrifugal separation (centrifuging at 3000r/min for 10 minutes) to obtain a crude water-soluble extract; drying under reduced pressure at 65 deg.C for 24 hr (pressure of-0.1 MPa) to obtain water soluble extract of radix Codonopsis.
The preparation method of the natural polysaccharide modified attapulgite comprises the following steps: mixing 10kg of Chondrus crispus extract and 90kg of high-purity attapulgite, placing the mixture into a ball mill, carrying out high-speed ball milling for 15 minutes under the condition of 1500r/min, dispersing the mixture into anhydrous ether, heating and stirring the mixture at 70 ℃ (the mass of the anhydrous ether is 18 times of that of the attapulgite, the rotating speed is 350r/min), removing generated water while reacting until no water is generated, carrying out reduced pressure distillation to remove reaction solvent ether (the reduced pressure distillation condition is 55 ℃ and is-0.1 MPa), and continuously carrying out air suction and vacuum drying at 65 ℃ for 48 hours to completely remove the ether, thus obtaining the natural polysaccharide modified attapulgite.
The preparation method of the ultrapure water comprises the following steps: tap water may be introduced into an ultrapure water preparation machine of commercially available hogfast instruments ltd and received from an ultrapure water outlet.
The preparation method of the anti-aging essence skin care lotion of the codonopsis pilosula extract comprises the steps of mixing water-soluble extract of the codonopsis pilosula extract, natural polysaccharide modified attapulgite, taurine, hyaluronic acid and ultrapure water according to a ratio, heating to 80 ℃ under the high pressure of 300MPa, then carrying out ultrasonic dispersion and assisting mechanical stirring until the mixture is colorless or light yellow transparent (the ultrasonic power is 120kHz, 300r/min and 25 minutes); sterilizing with ultraviolet rays to obtain the anti-aging essence skin care liquid (ultraviolet sterilization parameter: using at least 90 μ W/cm)2Not less than 25 seconds).
Example 2:
the product performance of the invention is evaluated:
comparative sample 1: a certain large brand of anti-aging skin care essence is sold in the market, and the packaged product is 30mL and the market price is 1230 yuan;
comparative sample 2: the best product of the invention is different from the best product of the invention in that only the codonopsis pilosula extract (water-soluble extract) is contained;
comparative sample 3: the difference from the best product of the invention is that the added attapulgite carrier is pure attapulgite, and the others are consistent;
comparative sample 4: the difference from the best product of the invention is that the product does not contain taurine, and the others are consistent;
comparative sample 5: the difference from the best product of the invention is that the hyaluronic acid is not contained, and the others are consistent.
1. And (3) testing the antibacterial performance:
1g of the product of the invention was taken out and tested in comparison with 1 to 5 products.
Preparation of test bacterial suspension: inoculating bacillus subtilis, escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and aspergillus niger into a test tube culture medium, culturing for 48 hours at 37 ℃ in a thermostat, adding sterile ultrapure water, and shaking to obtain an experimental bacteria suspension. 15mL of the melted SOB medium was taken and placed in a sterile plate, and then 1mL of the experimental strain was added dropwise and allowed to spread flat on the bottom of the plate. After the culture medium is solidified, 4 Oxford cups are vertically placed on each flat plate, then 0.1mL of the product and the comparison product are respectively added, and the size (unit: mm) of the diameter of the inhibition zone is respectively measured after the culture is carried out for 24 hours at 37 ℃.
The results of the bacteriostatic experiments are shown in table 1.
TABLE 1
2. And (3) stability testing:
30mL of the product of the invention is taken, compared with 1-5 of the product, and is put into the environment of 50 ℃, 25 ℃ and-25 ℃ respectively for stability test, and the contrast observation is carried out for 1 time every 1 week for 1 month continuously, and then the contrast observation is carried out for 1 time every 3 months for 10 months continuously.
The standard is that the product has no abnormal conditions with obvious changes such as precipitation, peculiar smell, color change and the like.
The results of the stability experiments are shown in Table 2.
TABLE 2
3. And (3) evaluation of moisturizing effect:
subject: normal female subjects between 30 and 60 years of age. The subjects are divided into 30-35-year-old groups according to all age groups, and each group contains 10 persons; groups of 35-40 years old, each group containing 10 persons; groups of 40-45 years old, each group containing 10 persons; groups of 45-50 years old, each group containing 10 persons; 50-55 years old, 10 people each; groups of 55-60 years old, 10 people each. After 2 hours of skin cleansing, the product of the invention and the comparative product (1 g each) were applied and skin moisture was measured at 1h, 4h, 8h, 12h, 16h and 24h, respectively. The measurements were carried out using a skin moisture tester of Delfin vapormer, finland at 25 ℃, 50% relative humidity and the mean values were finally calculated to give the results of the table below.
The moisturizing experimental results are shown in table 3.
TABLE 3
As can be seen from Table 3, the moisturizing effect of the anti-aging essence is obviously better than that of the comparative example, and after the anti-aging essence prepared by the invention is compounded through scientific combination, the characteristics of the components play a role in complementation of advantages, so that the anti-aging essence has a good moisturizing effect.
4. Anti-aging test:
testing an instrument: skin elasticity, model MPA580 host manufactured by CK company, germany, the probe used was a Reviscometer RV600 elasto-fibrous tissue test probe.
Subject: normal female subjects between 30-60 years of age. The subjects are divided into 30-35-year-old groups according to all age groups, and each group contains 10 persons; groups of 35-40 years old, each group containing 10 persons; groups of 40-45 years old, each group containing 10 persons; groups of 45-50 years old, each group containing 10 persons; 50-55 years old, 10 people each; groups of 55-60 years old, 10 people each. Each group used 1g of the product of the process and the comparative product.
The tester area: the forehead area 2cm above the middle of the eyebrow, the chin area 2cm below the middle of the lower lip, and the left and right cheek areas at the intersection of the nose tip and the pupil.
The test method comprises the following steps:
constant negative pressure mode (-), negative pressure set to 450 mbar.
Uf-maximum amount of skin stretching;
Ue-the amount of stretching of the skin at 0.1 seconds after a constant negative pressure has been applied to the skin, to locate the amount of stretching of the elastic portion;
Uv—Uf-Uethe amount of stretching of the viscoelastic part of the skin, or the plastic part.
For the skin, the younger the skin, the skin with good elasticity, UeThe higher the value of (A), and for aged skin, less elastic skin, the value of the elastic fraction UeRelatively low, and a viscoelastic part value UvThe value is relatively high.
UrAfter the negative pressure is removed, the skin is rapidly restored, again with a value of the elastic part UrI.e. the recovery value of the skin and the value of the viscoelastic part, or the value of the plastic part, after 0.1 second of removal of the negative pressure.
Ua-the recovery value of the skin from the removal of the negative pressure to the next successive testing of the skin surface plus the negative pressure.
Similarly, the younger skin is more elastic, and the elastic part value UrHigher, old skin, poor elasticity, UrThe lower the value.
The testing steps are as follows:
and measuring a blank value of 30min after the cleaning of the area in the test area, and finally calculating the increase rate of the skin elasticity through the test value to determine the anti-aging effect, wherein the higher the increase rate of the skin elasticity is, the better the anti-aging effect is. All data were averaged after testing and were used continuously for 6 months, once a month.
The statistical data of the anti-aging test are shown in table 4.
TABLE 4
As can be seen from Table 4, after 2 months of experiments, the anti-aging essence of the invention has outstanding effect, and shows that the anti-aging essence of the invention has the effect of obviously improving the elasticity of the skin and resisting aging. Especially more remarkable for the experiencers in the age stage of 40-55 years.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The anti-aging essence skin care lotion containing the codonopsis pilosula extract is characterized by being prepared from the following raw materials in parts by weight: 40 parts of codonopsis pilosula extract water-soluble extract, 5 parts of natural polysaccharide modified attapulgite, 2 parts of taurine, 10 parts of hyaluronic acid and 43 parts of ultrapure water.
2. The anti-aging essence skin care lotion containing codonopsis pilosula extract according to claim 1, wherein the preparation method of the water-soluble extract of codonopsis pilosula extract comprises the following steps:
1) cleaning radix Codonopsis, removing silt, drying at 45 deg.C for 24 hr, slicing, and micronizing to D100 no less than 1250 mesh;
2) placing 5kg of radix Codonopsis powder obtained in step 1) in a container, adding 10kg of anhydrous ethanol, refluxing at 80 deg.C for 2 hr, filtering with 0.45 μm microporous membrane to obtain a filtrate, repeating the above operation for 2 times, drying the residue under reduced pressure until ethanol is completely removed, and distilling under reduced pressure at 65 deg.C under-0.1 MPa;
3) adding the dried filter residue into an ultrasonic extractor, adding ultrapure water with the mass of 10 times, performing ultrasonic stirring extraction for 2 hours at 100 ℃, performing ultrasonic power of 60kHz, filtering out a solution through a 0.45-micron microporous filter membrane, repeating the operation for 2 times, and performing ultrasonic extraction and filtration for 3 times in total;
4) combining the filtrates for 3 times, adding a commercially available edible oil decolorizing agent, namely a commercially available modified active attapulgite edible oil decolorizing agent, in an amount of 3% of the total solution mass, stirring for 15 hours at 150-300 r/min to enable the decolorizing agent to fully adsorb pigments in the solution, and then performing filter pressing separation on the decolorizing agent and the aqueous solution by using a 0.45-micron microporous filter membrane at a filter pressing pressure of 0.159 MPa;
concentrating the separated water solution to one third of the mass, adding anhydrous ethanol with the mass 10 times of that of the concentrated solution into the concentrated solution, and centrifuging at 3000r/min for 10 minutes after the water-soluble substances are completely precipitated to obtain a crude water-soluble extract; drying at 65 deg.C under reduced pressure of-0.1 MPa for 24 hr to obtain water soluble extract of radix Codonopsis.
3. The anti-aging essence skin moisturizer containing the codonopsis pilosula extract as claimed in claim 1, wherein the preparation method of the natural polysaccharide modified attapulgite comprises the following steps: mixing 10 parts of carrageen crispus extract and 90 parts of commercially available high-purity attapulgite, placing the mixture into a ball mill, carrying out high-speed ball milling for 15 minutes under the condition of 1500r/min, dispersing the mixture into anhydrous ether, heating and stirring the anhydrous ether at 70 ℃ for 18 times of the mass of the attapulgite, stirring the mixture at the rotating speed of 350r/min, removing generated water while reacting until no water is generated, carrying out reduced pressure distillation to remove reaction solvent ether, wherein the reduced pressure distillation condition is 55 ℃, the pressure is-0.1 MPa, and continuously carrying out air suction and vacuum drying at 65 ℃ for 48 hours to completely remove ether, thus obtaining the natural polysaccharide modified attapulgite.
4. The anti-aging essence skin care lotion containing codonopsis pilosula extracts as claimed in claim 1, wherein the preparation method of ultrapure water comprises the following steps: tap water was introduced into a commercially available ultrapure water preparation machine and received from an ultrapure water outlet.
5. The preparation method of the codonopsis pilosula extract anti-aging essence skin care lotion according to any one of claims 1 to 4, characterized in that 40 parts of codonopsis pilosula extract water-soluble extract, 5 parts of natural polysaccharide modified attapulgite, 2 parts of taurine, 10 parts of hyaluronic acid and 43 parts of ultrapure water are mixed and added into a high-pressure homogenizer, the mixture is heated to 80 ℃ under the high pressure of 300MPa, then ultrasonic dispersion is carried out and mechanical stirring is assisted until the mixture is colorless or yellowish transparent, the ultrasonic power is 120kHz, the stirring speed is 300r/min, and the time is 25 minutes; and then sterilizing and disinfecting by ultraviolet rays to obtain the codonopsis pilosula extract anti-aging essence skin care lotion, wherein the ultraviolet sterilization parameters are as follows: using a particle size of 90. mu.W/cm or more2The ultraviolet lamp is irradiated for not less than 25 seconds.
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Application publication date: 20200612 |