CN108904376B - Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof - Google Patents
Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects, and preparation and application thereof, and belongs to the field of cosmetics. The traditional Chinese medicine compound fermentation liquor for cosmetics is prepared from the following traditional Chinese medicine components in parts by weight: 5-30 parts of loquat leaves, 5-25 parts of olive leaves, 5-25 parts of wild chrysanthemum flowers, 5-20 parts of cogongrass rhizome, 5-20 parts of sophora flower buds, 5-20 parts of sophora flavescens, 5-25 parts of coptis chinensis and 5-20 parts of liquorice. The invention takes the monarch, minister, assistant and guide theory of traditional Chinese medicine as guidance to carry out prescription, and achieves the aims of controlling oil and removing acne through the synergistic effect of a plurality of traditional Chinese medicines. The method adopts a fermentation extraction method, namely, the traditional Chinese medicine compound fermentation liquor is obtained by filtering, sterilizing and centrifugally separating after the traditional Chinese medicine compound mixture is fermented. The traditional Chinese medicine compound fermentation liquor disclosed by the invention can effectively reduce skin grease secretion and remove whelks, is safe and non-irritant to skin, is used in cosmetics for controlling and removing acnes, and has good effects of controlling and removing acnes.
Description
Technical Field
The invention relates to a traditional Chinese medicine compound fermentation broth for cosmetics, in particular to a traditional Chinese medicine compound fermentation broth for cosmetics with oil control and acne removal effects, and preparation and application thereof, and belongs to the field of cosmetics.
Background
Sebum is oil that is produced by sebocytes within the skin and is secreted to the surface of the skin. Excessive sebum secretion can cause the skin to shine and create an uncomfortable tactile sensation. The secretion function of sebaceous glands is vigorous for people with oily skin, particularly in summer, the metabolism of the human body is accelerated, the activities of sweat glands and sebaceous glands in the body are enhanced, the secretion of sebum is increased, the beauty is influenced, excessive sebum is accumulated, skin diseases such as acne and comedo are easily caused, and therefore, the control of excessive oil secretion is necessary to a certain extent.
At present, a plurality of oil control cosmetics on the market have the defects of effectiveness and safety:
1. oil control cosmetic with oil absorbing powder component: such oil control cosmetics mainly employ some oil-absorbing powder ingredients such as silica, titanium dioxide, and the like. These components are derived from synthetic or mineral components, and have the ability to reduce oil secretion for a short time, are difficult to control oil secretion for a long time, and are relatively likely to cause skin allergy.
2. Oil control cosmetics added with algefacient: the algefacient mainly comprises alcohol and herba Menthae, both of which have the effect of instantly shrinking pores. However, the cooling effect is only palliative, i.e., the astringent effect disappears after a short time, and the subsequent exuded oil cannot be effectively controlled.
3. Oil control cosmetics added with vitamins: the oil control cosmetic takes vitamins as oil conditioning components, mainly aims at people suffering from lipid leakage dermatitis caused by vitamin B6 deficiency, and can obtain the effect of treating the root cause by selecting oil control products matched with vitamin B6, vitamin B3 and vitamin H for oily skin with pimples and lipid leakage oily skin which is often accompanied with inflammation. However, people who have oily skin generally do not necessarily use such oil-controlling cosmetics effectively.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention mainly aims to provide the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes. The traditional Chinese medicine compound fermentation liquor for cosmetics has good effects of reducing oil secretion and controlling oil secretion for a long time, and has high safety.
The invention also aims to provide a preparation method of the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes.
The invention further aims to provide application of the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects is prepared from the following traditional Chinese medicine components in parts by weight: 5-30 parts of loquat leaves, 5-25 parts of olive leaves, 5-25 parts of wild chrysanthemum flowers, 5-20 parts of cogongrass rhizome, 5-20 parts of sophora flower buds, 5-20 parts of sophora flavescens, 5-25 parts of coptis chinensis and 5-20 parts of liquorice.
Preferably, the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes is prepared from the following traditional Chinese medicine components in parts by weight: 10-20 parts of loquat leaves, 10-15 parts of olive leaves, 10-12 parts of wild chrysanthemum flowers, 10-15 parts of cogongrass rhizome, 10-15 parts of sophora flower buds, 10-15 parts of sophora flavescens, 10-15 parts of coptis chinensis and 10-15 parts of liquorice.
Preferably, the traditional Chinese medicine compound fermentation liquor (I) for cosmetics with the effects of controlling oil and removing acnes is prepared from the following traditional Chinese medicine components in parts by weight: 10 parts of loquat leaves, 15 parts of olive leaves, 10 parts of wild chrysanthemum flowers, 10 parts of cogongrass rhizome, 15 parts of sophora flower buds, 15 parts of sophora flavescens ait, 10 parts of coptis chinensis and 15 parts of liquorice.
Preferably, the traditional Chinese medicine compound fermentation liquor (II) for cosmetics with the effects of controlling oil and removing acnes is prepared from the following traditional Chinese medicine components in parts by weight: 15 parts of loquat leaves, 10 parts of olive leaves, 12 parts of wild chrysanthemum flowers, 12 parts of lalang grass rhizome, 11 parts of sophora japonica, 15 parts of sophora flavescens, 12 parts of coptis chinensis and 13 parts of liquorice.
Preferably, the traditional Chinese medicine compound fermentation liquor (III) for cosmetics with the effects of controlling oil and removing acnes is prepared from the following traditional Chinese medicine components in parts by weight: 20 parts of loquat leaves, 10 parts of olive leaves, 10 parts of wild chrysanthemum flowers, 15 parts of lalang grass rhizome, 10 parts of sophora japonica, 10 parts of sophora flavescens, 15 parts of coptis chinensis and 10 parts of liquorice.
Preferably, the composite bacteria used for fermentation are lactobacillus plantarum and saccharomyces cerevisiae;
preferably, the lactobacillus plantarum and the saccharomyces cerevisiae in the composite bacteria are mixed according to the proportion (1-6): 1 composition, the concentration of the compound bacterial liquid is 106～108cfu/mL。
The second purpose of the invention is to provide a preparation method of the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes.
In order to prepare the fermentation liquor, the invention adopts a fermentation extraction method, namely, the traditional Chinese medicine compound fermentation liquor is obtained by filtering, sterilizing and centrifugally separating after the traditional Chinese medicine compound mixture is fermented. The method specifically comprises the following steps:
① the composite bacteria is added in the form of bacteria liquid, the composite bacteria liquid is composed of lactobacillus plantarum and saccharomyces cerevisiae according to the proportion of (1-6): 1, and the concentration of the composite bacteria liquid is 106～108cfu/mL；
② preparing raw materials, removing impurities from the raw materials, cleaning, oven drying, pulverizing to 40-200 mesh, mixing to obtain compound Chinese medicinal mixture with a concentration of 10%6～108Adjusting the pH value of the cfu/m L composite bacterial liquid to 6.5-7.5;
③ fermenting, namely mixing the compound bacterial liquid, the compound traditional Chinese medicine mixture and water according to the proportion, and fermenting for 36-48 hours at the temperature of 28-42 ℃ and at the speed of 50-300 r/min to obtain fermentation liquid;
④ purifying, filtering the fermentation liquor, sterilizing the filtrate at 105-120 deg.C under high pressure for 20-35 min to inactivate the bacteria, centrifuging the sterilized fermentation filtrate at 3000-8000 r/min and a centrifugation radius of 5-20 cm for 20-35 min, discarding the precipitate, collecting the supernatant, concentrating with a membrane, adsorbing the concentrate with macroporous resin, eluting with 10-95% ethanol for multiple times, collecting the eluate, concentrating with a membrane to a concentrate with the same weight as the Chinese medicinal compound mixture, adding butanediol with the same weight as the concentrate, dissolving, and filtering to obtain the Chinese medicinal compound fermentation liquor with effects of controlling oil and removing acne.
Preferably, in the step ①, the composite bacterial liquid is composed of lactobacillus plantarum and saccharomyces cerevisiae according to a ratio of 3: 1;
preferably, in step ②, the powder is ground to 80 mesh.
Preferably, in step ③, fermenting at 30-35 deg.C for 40 hr at 100r/min to obtain fermentation liquid;
the dosage ratio of the compound bacterial liquid, the traditional Chinese medicine compound mixture and water is 20m L-60 m L: 20 g-60 g: 200-600 g.
Preferably, the dosage ratio of the compound bacterial liquid to the traditional Chinese medicine compound mixture to water is 35m L-45 m L: 35 g-50 g: 300-400 g.
Preferably, the dosage ratio of the traditional Chinese medicine compound fermentation liquor (I), the compound bacterial liquid, the traditional Chinese medicine compound mixture and water is 40m L: 40 g: 300 g.
Preferably, the dosage ratio of the traditional Chinese medicine compound fermentation liquid (II), the compound bacterial liquid, the traditional Chinese medicine compound mixture and the water is 45m L: 50 g: 400 g.
Preferably, the dosage ratio of the traditional Chinese medicine compound fermentation liquor (III), the compound bacterial liquid, the traditional Chinese medicine compound mixture and water is 35m L: 35 g: 300 g.
Preferably, the centrifugal radius in the step ④ is 8-12 cm.
Preferably, in step ④, the filtrate is autoclaved at 105-120 deg.C for 30min to inactivate the strains, the sterilized fermentation filtrate is centrifuged at 4000r/min with a centrifugation radius of 10cm for 30min, the precipitate is discarded, and the supernatant is collected.
The third purpose of the invention is to apply the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil-controlling and acne-removing effects to cosmetics, and provide the cosmetics with the oil-controlling and acne-removing effects.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
the application of the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil control and acne removal effects in preparing cosmetics is characterized in that the addition amount of the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil control and acne removal effects in the cosmetics is 0.1-20% by mass.
The invention also provides a cosmetic with the oil control and acne removal effects, which contains the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil control and acne removal effects.
Preferably, the cosmetic contains 0.1-20% of the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil-controlling and acne-removing effects by mass fraction.
The cosmetic is as follows: aqueous preparations, emulsions, creams, gels, powders, powder-forming products, facial masks, sprays, essences, and lotions.
Specifically, the invention provides oil-controlling acne-removing toner which comprises the following components in parts by mass:
| name of raw materials | Mass fraction/% |
| Deionized water | To 100 of |
| EDTA-2Na | 0.02 |
| Glycerol | 5 |
| Panthenol | 0.2 |
| 1, 3-butanediol | 5 |
| Hyaluronic acid sodium salt | 0.05 |
| Preservative | Proper amount of |
| The Chinese herbal compound fermentation liquor of the invention | 5 |
| Essence | Proper amount of |
Specifically, the invention provides oil-controlling acne-removing skin care cream which comprises the following components in parts by mass:
specifically, the invention provides an oil-controlling acne-removing mask which comprises the following components in parts by mass:
| components | Mass fraction/% |
| The traditional Chinese medicine compound fermentation liquor of the invention | 5 |
| Glycerol | 5.00 |
| 1, 3-propanediol | 5.00 |
| Hyaluronic acid sodium salt | 0.10 |
| Xanthan gum | 0.10 |
| Hydroxyethyl cellulose | 0.12 |
| Glycyrrhizic acid dipotassium salt | 0.60 |
| Aloe extract | 1.20 |
| 1, 2-hexanediol | 0.80 |
| P-hydroxyacetophenone | 0.40 |
| Deionized water | Balance of |
The mechanism of the invention is as follows:
the beauty theory of traditional Chinese medicine holds that good skin needs external decoration, and more importantly, the skin is healthy from inside to outside. The traditional Chinese medicine considers that acne is formed mostly due to blood heat, blood deficiency and wind dryness, heat toxin, dampness and the like, so the common method for treating acnes is also from the aspects of clearing heat, dispelling toxin and eliminating dampness.
The invention takes the monarch, minister, assistant and guide theory of the traditional Chinese medicine as guidance to carry out the prescription, takes the loquat leaves as monarch drug, and the loquat leaves have the effects of clearing away heat and toxic material, eliminating phlegm and relieving cough, and simultaneously have good antibacterial and grease secretion control functions; flos Chrysanthemi Indici, lalang grass rhizome, and flos Sophorae Immaturus are ministerial drugs, flos Chrysanthemi Indici has effects of clearing heat and detoxicating, dispelling pathogenic wind and heat, and removing blood stasis, lalang grass rhizome has effects of cooling blood and hemostasis, clearing heat and promoting urination, and flos Sophorae Immaturus has effects of cooling blood and hemostasis, clearing liver-fire and lowering fire, and resisting inflammation, and resisting oxidation; the sophora flavescens, the olive leaves and the coptis are used as adjuvant drugs together, the sophora flavescens has the effects of clearing heat and drying dampness, killing insects and promoting urination and has good antibacterial effect, the olive leaves have the broad-spectrum antibacterial effect and good antioxidant effect, and the coptis has the effects of clearing heat and drying dampness, purging intense heat and removing toxicity and has good antibacterial effect; the licorice root is a guiding drug, has the effects of clearing away heat and toxic materials, resisting inflammation, resisting free radicals and the like, and has the effect of harmonizing the medicines. The medicines are used together to strengthen the body resistance, consolidate the vitality, nourish and condition, and remove heat, poison and dampness as the basis for removing acnes; the anti-pollution targets are anti-inflammation, sterilization and anti-oxidation. The traditional Chinese medicine compound fermentation liquor disclosed by the invention has very good comprehensive effects of oil control, bacteriostasis, oxidation resistance and the like, and is obvious in acne removing effect when added into acne removing cosmetics.
Compared with the prior art, the invention has the following advantages and effects:
the traditional Chinese medicine composition is formulated by taking the monarch, minister, assistant and guide theory of traditional Chinese medicine as guidance, and achieves the aims of controlling oil and removing acnes from the aspects of comprehensive effects of controlling oil, inhibiting bacteria, resisting oxidation and the like through the synergistic effect of various traditional Chinese medicines. The preparation method adopts a fermentation extraction method, namely, the traditional Chinese medicine compound fermentation liquor is obtained by filtering, sterilizing and centrifugally separating after the traditional Chinese medicine compound mixture is fermented. The traditional Chinese medicine compound fermentation liquor disclosed by the invention can effectively reduce skin grease secretion and remove whelks, is safe and non-irritant to skin, is used in cosmetics for controlling and removing acnes, and has good effects of controlling and removing acnes.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
The test methods in the following examples, in which specific experimental conditions are not specified, are generally performed according to conventional experimental conditions or according to the experimental conditions recommended by the manufacturer.
The lactobacillus plantarum used in the examples (L actinobacillus plantarum), available from changzhou probiotic gazette ltd, model NJ 2205;
saccharomyces cerevisiae (Saccharomyces cerevisiae) used in the examples was purchased from Kyork, Guangdong, Inc., model ATCC 9763;
propionibacterium acnes (Propionibacterium acnes) used in the examples were obtained from Kyork, Guangdong, Inc. of Microbiol. technology, model GIM 1.162.
Example 1A Chinese medicinal compound fermentation broth for cosmetics with oil-controlling and acne-removing effects (I)
A traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects is prepared from the following traditional Chinese medicine components in parts by weight: 10 parts of loquat leaves, 15 parts of olive leaves, 10 parts of wild chrysanthemum flowers, 10 parts of cogongrass rhizome, 15 parts of sophora flower buds, 15 parts of sophora flavescens ait, 10 parts of coptis chinensis and 15 parts of liquorice.
The preparation method comprises the following steps:
① the composite bacteria is added in the form of bacteria liquid, the composite bacteria liquid is composed of Lactobacillus plantarum and Saccharomyces cerevisiae at a ratio of 3: 1, and the concentration of the composite bacteria liquid is 106～108cfu/mL。
② preparing raw materials, removing impurities from the raw materials, cleaning, oven drying, pulverizing to 80 mesh, mixing to obtain compound Chinese medicinal mixture with a concentration of 10%6～108The pH value of the cfu/m L composite bacterial liquid is adjusted to 6.5-7.5.
③ fermenting, mixing the compound bacteria liquid, the compound Chinese medicinal mixture and water according to a ratio, and fermenting for 40 hours in a shaking table at 30-35 ℃ and 100r/min to obtain the fermentation liquid.
④ purifying, filtering the obtained fermentation liquor, sterilizing the filtrate at 105-120 deg.C under high pressure for 30min to inactivate the strain, centrifuging the sterilized fermentation filtrate for 30min at 4000r/min with a centrifugation radius of 10cm, discarding the precipitate, collecting the supernatant, concentrating with membrane, adsorbing the concentrated solution with macroporous resin (AB-8 macroporous adsorbent resin, available from Tianjin Pradde Biotech limited), eluting with 10-95% ethanol for multiple times, collecting the eluate, concentrating with membrane to the same weight as the Chinese medicinal compound mixture, adding butanediol to dissolve the concentrated solution, and filtering to obtain the Chinese medicinal compound fermentation liquor (I).
The dosage ratio of the compound bacterial liquid, the traditional Chinese medicine compound mixture and water is 40m L: 40 g: 300 g.
Embodiment 2A Chinese medicinal compound fermentation broth for cosmetics with oil control and acne removing effects (II)
A traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects is prepared from the following traditional Chinese medicine components in parts by weight: 15 parts of loquat leaves, 10 parts of olive leaves, 12 parts of wild chrysanthemum flowers, 12 parts of lalang grass rhizome, 11 parts of sophora japonica, 15 parts of sophora flavescens, 12 parts of coptis chinensis and 13 parts of liquorice.
The preparation method is consistent with the example 1 except that the dosage ratio of the compound bacterial liquid, the compound traditional Chinese medicine mixture and the water is 45m L: 50 g: 400g, and the traditional Chinese medicine compound fermentation liquid (II) provided by the invention is prepared.
Embodiment 3A Chinese medicinal compound fermentation broth (III) for cosmetics with oil-controlling and acne-removing effects
A traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects is prepared from the following traditional Chinese medicine components in parts by weight: 20 parts of loquat leaves, 10 parts of olive leaves, 10 parts of wild chrysanthemum flowers, 15 parts of lalang grass rhizome, 10 parts of sophora japonica, 10 parts of sophora flavescens, 15 parts of coptis chinensis and 10 parts of liquorice.
The preparation method is the same as the embodiment 1 except that the dosage ratio of the compound bacterial liquid, the compound traditional Chinese medicine mixture and the water is 35m L: 35 g: 300g, and the traditional Chinese medicine compound fermentation liquid (III) provided by the invention is prepared.
Comparative examples 1-8 fermentation liquor of single Chinese medicine
100 parts of loquat leaves, 100 parts of olive leaves, 100 parts of wild chrysanthemum flowers, 100 parts of lalang grass rhizome, 100 parts of sophora flower buds, 100 parts of radix sophorae flavescentis, 100 parts of coptis chinensis and 100 parts of liquorice are respectively weighed. Fermenting and extracting according to the preparation method of the embodiment 1, and sequentially and respectively preparing single traditional Chinese medicine fermentation liquor.
Comparative example 9 Chinese medicinal compound extract
According to the dosage of the traditional Chinese medicine compound mixture consistent with the embodiment 1, the traditional Chinese medicine compound mixture is prepared from the following traditional Chinese medicine components in parts by weight: 10 parts of loquat leaves, 15 parts of olive leaves, 10 parts of wild chrysanthemum flowers, 10 parts of cogongrass rhizome, 15 parts of sophora flower buds, 15 parts of sophora flavescens ait, 10 parts of coptis chinensis and 15 parts of liquorice.
The preparation method comprises the following steps: removing impurities from the traditional Chinese medicine raw materials, cleaning, drying, crushing to 100 meshes, adding deionized water according to the liquid-material mass ratio of 8:1, soaking for 2.5h, extracting at normal temperature by using a high-pressure homogenizing extractor under the extraction pressure of 60MPa, centrifugally separating the extract, concentrating by using a membrane, adsorbing the concentrate by using macroporous resin, eluting for multiple times by using ethanol with the volume fraction of 10-95%, collecting the eluent, concentrating by using the membrane to obtain the concentrate with the same weight as the traditional Chinese medicine, adding butanediol with the same weight as the concentrate for dissolving, and filtering to obtain the traditional Chinese medicine compound extract.
Test example 1 evaluation of efficacy in inhibiting Propionibacterium acnes
1. Preparation of Chinese medicine extract sample
The traditional Chinese medicine compound fermentation liquor for cosmetics with the oil-controlling and acne-removing effects prepared in the embodiment 1, the single traditional Chinese medicine fermentation liquor prepared in the comparative examples 1-8 and the traditional Chinese medicine compound extracting solution prepared in the comparative example 9 are prepared into sample aqueous solutions with the mass fractions of 0.5%, 1.0%, 1.5%, 2.0% and 3.0% for later use.
2. Method for testing inhibition capacity of propionibacterium acnes
10 kinds of aqueous solutions 1m L were each added to a sterile glass test tube, and 8m L of a previously prepared modified GAM broth (Nissui, Japan, No. ZZM-05433) was poured, and the resulting mixture was taken out, purified and CO-incubated at 35 deg.C2Culturing clinical Propionibacterium acnes in incubator for 48h, respectively injecting 1m L bacterial suspension into improved GAM broth culture medium test tube containing sample water solution, using a glass test tube containing no bacterial suspension as negative control, sequentially inoculating Propionibacterium acnes in each sample culture medium from low concentration, and placing at constant temperature of 35 deg.C and CO as soon as possible2The incubator is used for 48 hours. After the culture, the liquid in the improved GAM broth culture medium was first extracted for preliminary verification experiments, and then the kill of Propionibacterium acnes was determined by a VITEK full-automatic microbiological analysis system and an ANI anaerobe identification card, with the results as shown in Table 1 below.
TABLE 1 Propionibacterium acnes kill
The comparison result of the embodiment 1 and the comparative examples 1-8 shows that the traditional Chinese medicine compound fermentation liquor prepared by the invention has an obvious inhibition effect on propionibacterium acnes, and the effect is much better than that of the single traditional Chinese medicine fermentation liquor prepared by the comparative example 8, which shows that the synergistic effect of the traditional Chinese medicine components is obvious after the compound treatment. In addition, the bacteriostatic effect of the example 1 is obviously better than that of the comparative example 9, which shows that the bacteriostatic effect of the traditional Chinese medicine compound mixture is obviously enhanced after fermentation.
Test example 2 evaluation experiment of oil control efficiency
1. Principle of experiment
The skin was tested for oil content using a grease tester Sebumeter SM 815. Based on the principle of a photometer, a special extinction adhesive tape with the thickness of 0.1mm can be changed into a semitransparent adhesive tape after absorbing grease on human skin, the light transmission quantity of the semitransparent adhesive tape can be changed, the more grease is absorbed, the greater the light transmission quantity is, and the content of the grease on the skin can be measured.
2. The test instrument:
sebumeter SM815 (Courage + Khazaha, Germany)
3. Test sample
Test samples #1 to #3 were prepared including the components in the mass percentages as shown in table 2.
TABLE 2 compositions of test samples #1 to #3
| Name of raw materials | #1 | #2 | #3 |
| Deionized water | Balance of | Balance of | Balance of |
| EDTA-2Na | 0.02％ | 0.02％ | 0.02％ |
| Glycerol | 5％ | 5％ | 5％ |
| Panthenol | 0.2％ | 0.2％ | 0.2％ |
| 1, 3-butanediol | 8％ | 8％ | 8％ |
| Hyaluronic acid sodium salt | 0.05％ | 0.05％ | 0.05％ |
| Preservative | Proper amount of | Proper amount of | Proper amount of |
| Fermentation broth according to example 1 | 5％ | / | / |
| Extract liquid described in comparative example 9 | / | 5％ | / |
The preparation method comprises the following steps:
(1) mixing and stirring raw materials including deionized water, EDTA-2Na, glycerol and panthenol, heating to 80 ℃, and stirring until the raw materials are transparent and completely dissolved;
(2) mixing the raw materials 1, 3-butanediol and sodium hyaluronate at normal temperature, uniformly stirring, adding the mixture into the solution obtained in the step (1), keeping the temperature at 80 ℃ for 10 minutes, and uniformly stirring;
(3) cooling to 45 deg.C under stirring, adding the rest materials, and stirring;
(4) vacuum defoaming, discharging at 38 deg.C or below, and making the material body be aqueous solution.
Respectively preparing samples #1 to #3 according to a preparation method, wherein the samples #2 to #3 are comparison samples, selecting a cosmetic which has better sales and is declared to have the effects of controlling oil and removing acnes on the market, and filling the cosmetic into a sample bottle, wherein the sample bottle is marked as a sample #4 and is also used as a comparison sample.
4. Test object
1. 180 oily skin volunteers aged 20-40 years old;
2. patients without severe systemic disease, immunodeficiency or autoimmune disease, the subject site has not received skin treatment, cosmetic and other tests that may affect outcome; those with inactive allergic disease; those without constitutional hypersensitivity; hormone drugs and immunosuppressants have not been used in the last month; the test sites were not enrolled in other clinical trials now or in the last three months.
5. Test method
The subjects were randomly divided into 3 groups of 30, and the group numbers were #1 to #2 and # 4. The subjects sit still for 30 minutes in a laboratory with the temperature of 22 +/-3 ℃ and the relative humidity of 50 +/-5 percent, the skin oil content of the left forehead and the right forehead is respectively tested by using an oil tester Sebumeter SM815 and the data is recorded as D0, the samples #3 and the correspondingly numbered samples of each group are distributed to each subject, the subjects are guided to carry out half-face comparison and trial, the two samples are respectively smeared on the left half-face or the right half-face, 0.5g of the sample is smeared once in the morning and at the evening every day and lasts for 28 days, and the skin oil content is respectively tested by returning to the constant temperature laboratory on the 14 th day and the 28 th day and the data is recorded as D14 and D28. Respectively calculating the oil content change rate of D14 and D28 according to the following formula:
oil content change rate { (oil content after use sample-oil content before use sample)/oil content before use sample } × 100%
(4) The experimental results are as follows:
the results are shown in Table 3.
TABLE 3 rate of change of oil content
| Test sample | D14 change in fat (%) | D28 change in fat (%) |
| Sample #1 | -23.9％ | -39.6％ |
| Sample #2 | -17.4 | -29.6％ |
| Sample #4 | -12.5％ | -20.3％ |
The result shows that the skin oil content is obviously reduced after 14 days of the experimental sample #1 added with the fermentation liquid prepared in the embodiment 1 of the invention, and the effect is more obvious after the continuous use for 28 days, while the oil control effect is obviously inferior to that of the sample #1 when the experimental sample #2 prepared by the extracting solution containing the comparative example 9 is continuously used, which shows that the acne removing effect of the traditional Chinese medicine compound is obviously enhanced after the fermentation. And the oil control effect of the samples #1 and #2 is much stronger than that of the sample #4, which shows that the traditional Chinese medicine compound of the invention has obvious oil control effect.
Test example 3 irritation evaluation test
Specifically, 500 mu L of the fermentation liquid prepared in example 1 and comparative examples 1 to 8 was placed in a 2m L centrifuge tube, and then 2% rabbit red blood cell (commercially available) suspension 500 mu L was added, the mixture was gently shaken and mixed, incubated in a 37 ℃ incubator for 3 hours, centrifuged at 2000r/min for 3 minutes, the supernatant was extracted, physiological saline was used as a negative control, distilled water was used as a positive control, the absorbance was measured at a wavelength of 414nm, and the hemolysis was calculated according to the formula, and the results are shown in Table 4.
TABLE 4 results of hemolysis
The comparison of the experimental results of the embodiment 1 and the comparative examples 1 to 8 shows that the hemolysis ratio of the fermentation liquid of the traditional Chinese medicine compound is much lower than that of the fermentation liquid of a single traditional Chinese medicine prepared by the comparative examples 1 to 8, and the irritation of the fermentation liquid after the compound is obviously reduced.
Application example 1 oil-controlling acne-removing toner
The formula of the oil-control acne-removing toner containing the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil-control acne-removing efficacy is shown in table 5.
TABLE 5 formula of oil-controlling acne-removing toner
| Name of raw materials | Mass fraction/% |
| Deionized water | To 100 of |
| EDTA-2Na | 0.02 |
| Glycerol | 5 |
| Panthenol | 0.2 |
| 1, 3-butanediol | 5 |
| Hyaluronic acid sodium salt | 0.05 |
| Preservative | Proper amount of |
| The invention relates to a Chinese medicine compound fermentation liquor (I) | 5 |
| Essence | Proper amount of |
The preparation method comprises the following steps:
(1) mixing and stirring raw materials including deionized water, EDTA-2Na, glycerol and panthenol, heating to 80 ℃, and stirring until the raw materials are transparent and completely dissolved;
(2) mixing the raw materials 1, 3-butanediol and sodium hyaluronate at normal temperature, uniformly stirring, adding the mixture into the solution obtained in the step (1), keeping the temperature at 80 ℃ for 10 minutes, and uniformly stirring;
(3) cooling to 45 deg.C under stirring, adding the rest materials, and stirring;
(4) vacuum defoaming, discharging at 38 deg.C or below, and making the material body be aqueous solution.
Application example 2 oil-controlling acne-removing skin-care lotion
The formula of the oil-controlling acne-removing skin care cream containing the traditional Chinese medicine compound fermentation liquor for cosmetics with the oil-controlling acne-removing efficacy is shown in table 6.
TABLE 6 formula of oil-controlling acne-removing skin-care lotion
| Name of raw materials | Mass fraction/% |
| Polyglyceryl-3-methylglucose distearate | 1.4 |
| Glycerol stearate | 0.8 |
| Palmitic acid isopropyl ester | 1.5 |
| Caprylic/capric triglyceride | 4 |
| Potentilla chinensis seed oil | 4 |
| Polydimethylsiloxane | 1 |
| Deionized water | To 100 of |
| EDTA-2Na | 0.02 |
| Glycerol | 3 |
| 1, 3-butanediol | 5 |
| Carbomer (CA) | 0.15 |
| Aminomethyl propanol | 0.09 |
| Preservative | Proper amount of |
| The invention relates to a Chinese medicine compound fermentation liquor (I) | 5 |
| Essence | Proper amount of |
The preparation method comprises the following steps:
(1) mixing raw materials including deionized water, EDTA-2Na, glycerol, 1, 3-butanediol and Carbomer (CA), stirring, heating to 80 ℃, and keeping the temperature for later use;
(2) mixing raw materials of polyglycerol-3 methyl glucose distearate, glycerol stearate, isopropyl palmitate, caprylic/capric triglyceride, meadowfoam seed oil and polydimethylsiloxane, stirring and heating to 80 ℃ until the raw materials are completely dissolved, quickly adding the mixture into the solution obtained in the step (1), and homogenizing for 15 minutes at the speed of 3000 revolutions per minute;
(3) cooling to 45 deg.C, adding the rest materials, and stirring;
(4) when the temperature is reduced to 38 ℃, vacuum defoaming is carried out, and the material body is emulsion.
Application example 3 oil-controlling acne-removing mask
The formula of the facial mask for controlling oil and removing acnes containing the traditional Chinese medicine compound fermentation liquid is shown in table 7.
TABLE 7 formula of facial mask for controlling oil and removing acne
| Components | Mass fraction/% |
| The invention relates to a Chinese medicine compound fermentation liquor (I) | 5 |
| Glycerol | 5.00 |
| 1, 3-propanediol | 5.00 |
| Hyaluronic acid sodium salt | 0.10 |
| Xanthan gum | 0.10 |
| Hydroxyethyl cellulose | 0.12 |
| Glycyrrhizic acid dipotassium salt | 0.60 |
| Aloe extract | 1.20 |
| 1, 2-hexanediol | 0.80 |
| P-hydroxyacetophenone | 0.40 |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) dispersing xanthan gum and sodium hyaluronate in glycerol in advance, adding into deionized water together with dipotassium glycyrrhizinate, hydroxyethyl cellulose and Chinese medicinal compound fermentation broth (I), stirring and dissolving until uniformly dispersed and transparent;
(2) heating and dissolving p-hydroxyacetophenone in 1, 3-propylene glycol and 1, 2-hexanediol in advance, putting the mixture into the solution in the step (1), and stirring and dissolving the mixture uniformly;
(3) adding Aloe extract, stirring to dissolve completely;
(4) and (5) inspecting the physicochemical indexes such as color, pH, fragrance and appearance, filtering with 200 meshes after passing inspection, and discharging.
Effect example 1 evaluation of acne removing Effect, oil controlling Effect and skin irritation
Evaluation target: 30 young people with acne on the face and the age of 15-30 years are selected, wherein 15 male people and 15 female people are selected.
The evaluation method comprises the following steps: the oil-control acne-removing mask prepared in application example 3 is applied to the face in the morning and at night every day by a double-blind method, and the face is massaged after the mask is taken down until all the mask liquid is absorbed by the skin.
Evaluation course of treatment: the acne removing effect evaluation takes 20 days as a treatment course, the oil control effect evaluation takes 28 days as a treatment course, and the irritation evaluation takes 20 days as a treatment course.
The evaluation standard of the acne removing effect is that ① has obvious effect that acne is removed by more than 70 percent, ② has effective effect that acne is removed by more than 30 percent, and ③ has no effect that acne is removed by less than 30 percent.
Evaluation standard of oil control effect: the test method was the same as that described in test example 2.
Irritation evaluation criteria: the examination was performed according to the criteria of Table 8. The experiment was carried out for a total of 20 days.
TABLE 8 irritation evaluation criteria
| Grade | Identification criteria |
| 0 | Negative reaction: has no irritation and erythema |
| 1 | And (3) suspicious reaction: mild erythema |
| 2 | Weak positive reaction: erythema |
| 3 | Strong positive reaction: erythema, papules, blisters |
| 4 | Extremely strong positive reaction: severe edema and bulla |
Evaluation results of acne removal effects: 15 cases of obvious effect account for 50 percent; 7 effective cases account for 23.3 percent; the number of the ineffective 8 cases is 26.7 percent. The total effective rate reaches 73.3 percent, which shows that the traditional Chinese medicine compound fermentation liquor has good acne removing effect.
Evaluation results of oil control effect: after 28 days, the skin oil reduction rate of the volunteers is 41.6%, which shows that the facial mask for controlling oil and removing acnes prepared in application example 3 has a good oil control effect.
Evaluation results of irritation: no allergic phenomenon was found in all volunteers.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (13)
1. A traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects is characterized in that: the traditional Chinese medicine compound fermentation liquor for cosmetics is prepared from the following traditional Chinese medicine components in parts by weight: 5-30 parts of loquat leaves, 5-25 parts of olive leaves, 5-25 parts of wild chrysanthemum flowers, 5-20 parts of cogongrass rhizome, 5-20 parts of sophora flower buds, 5-20 parts of sophora flavescens, 5-25 parts of coptis chinensis and 5-20 parts of liquorice;
the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes adopts a fermentation extraction method, namely, after the traditional Chinese medicine compound mixture is subjected to fermentation treatment, the traditional Chinese medicine compound fermentation liquor is obtained through filtration, sterilization and centrifugal separation;
the method specifically comprises the following steps:
① the composite bacteria is added in the form of bacteria liquid, the composite bacteria liquid is composed of lactobacillus plantarum and saccharomyces cerevisiae according to the proportion of (1-6): 1, and the concentration of the composite bacteria liquid is 106～108cfu/mL；
② preparing raw materials, removing impurities from the raw materials, cleaning, oven drying, pulverizing to 40-200 mesh, mixing to obtain compound Chinese medicinal mixture with a concentration of 10%6～108Adjusting the pH value of the cfu/m L composite bacterial liquid to 6.5-7.5;
③ fermenting, namely mixing the compound bacterial liquid, the compound traditional Chinese medicine mixture and water according to the ratio of 20m L-60 m L: 20 g-60 g: 200-600 g, and fermenting for 36-48 hours at the temperature of 28-42 ℃ under the condition of 50-300 r/min to obtain fermentation liquid;
④ purifying, filtering the fermentation liquor, sterilizing the filtrate at 105-120 deg.C under high pressure for 20-35 min to inactivate the bacteria, centrifuging the sterilized fermentation filtrate at 3000-8000 r/min and a centrifugation radius of 5-20 cm for 20-35 min, discarding the precipitate, collecting the supernatant, concentrating with a membrane, adsorbing the concentrate with macroporous resin, eluting with 10-95% ethanol for multiple times, collecting the eluate, concentrating with a membrane to a concentrate with the same weight as the Chinese medicinal compound mixture, adding butanediol with the same weight as the concentrate, dissolving, and filtering to obtain the Chinese medicinal compound fermentation liquor with effects of controlling oil and removing acne.
2. The traditional Chinese medicine compound fermentation liquor with the effects of controlling oil and removing acnes for cosmetics according to claim 1, which is characterized in that:
the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes is prepared from the following traditional Chinese medicine components in parts by weight: 10-20 parts of loquat leaves, 10-15 parts of olive leaves, 10-12 parts of wild chrysanthemum flowers, 10-15 parts of cogongrass rhizome, 10-15 parts of sophora flower buds, 10-15 parts of sophora flavescens, 10-15 parts of coptis chinensis and 10-15 parts of liquorice.
3. The preparation method of the traditional Chinese medicine compound fermentation liquor with the effects of controlling oil and removing acnes for cosmetics according to any one of claims 1 to 2 is characterized by comprising the following steps:
adopts a fermentation extraction method, namely, after the traditional Chinese medicine compound mixture is fermented, the traditional Chinese medicine compound fermentation liquor is obtained through filtration, sterilization and centrifugal separation;
the method specifically comprises the following steps:
① the composite bacteria is added in the form of bacteria liquid, the composite bacteria liquid is composed of lactobacillus plantarum and saccharomyces cerevisiae according to the proportion of (1-6): 1, and the concentration of the composite bacteria liquid is 106～108cfu/mL；
② preparing raw materials, removing impurities from the raw materials, cleaning, oven drying, pulverizing to 40-200 mesh, mixing to obtain compound Chinese medicinal mixture with a concentration of 10%6～108Adjusting the pH value of the cfu/m L composite bacterial liquid to 6.5-7.5;
③ fermenting, namely mixing the compound bacterial liquid, the compound traditional Chinese medicine mixture and water according to the ratio of 20m L-60 m L: 20 g-60 g: 200-600 g, and fermenting for 36-48 hours at the temperature of 28-42 ℃ under the condition of 50-300 r/min to obtain fermentation liquid;
④ purifying, filtering the fermentation liquor, sterilizing the filtrate at 105-120 deg.C under high pressure for 20-35 min to inactivate the bacteria, centrifuging the sterilized fermentation filtrate at 3000-8000 r/min and a centrifugation radius of 5-20 cm for 20-35 min, discarding the precipitate, collecting the supernatant, concentrating with a membrane, adsorbing the concentrate with macroporous resin, eluting with 10-95% ethanol for multiple times, collecting the eluate, concentrating with a membrane to a concentrate with the same weight as the Chinese medicinal compound mixture, adding butanediol with the same weight as the concentrate, dissolving, and filtering to obtain the Chinese medicinal compound fermentation liquor with effects of controlling oil and removing acne.
4. The application of the traditional Chinese medicine compound fermentation liquor with the oil-controlling and acne-removing effects for cosmetics as claimed in any one of claims 1-2 in preparing cosmetics.
5. Use according to claim 4, characterized in that:
the addition amount of the traditional Chinese medicine compound fermentation liquor for cosmetics with the effects of controlling oil and removing acnes in the cosmetics is 0.1-20% by mass.
6. A cosmetic with oil control and acne removal effects is characterized in that: the traditional Chinese medicine compound fermentation liquor with the oil-controlling and acne-removing effects for cosmetics contains the traditional Chinese medicine compound fermentation liquor with the oil-controlling and acne-removing effects of any one of claims 1-2.
7. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic contains 0.1-20% of traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects in percentage by mass;
the cosmetic is as follows: emulsions, creams, gels, powders, masks, sprays, essences.
8. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic contains 0.1-20% of traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects in percentage by mass;
the cosmetic is as follows: a water aqua.
9. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic contains 0.1-20% of traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects in percentage by mass;
the cosmetic is as follows: powder molding.
10. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic contains 0.1-20% of traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects in percentage by mass;
the cosmetic is as follows: washing and protecting.
11. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic is the oil-control acne-removing toner, and comprises the following components in parts by mass: 0.02% of EDTA-2Na, 5% of glycerol, 0.2% of panthenol, 5% of 1, 3-butanediol, 0.05% of sodium hyaluronate, a proper amount of preservative, 5% of Chinese herbal compound fermentation liquor, a proper amount of essence and deionized water are added to 100%.
12. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic is oil-control acne-removing skin-care emulsion, and comprises the following components in parts by mass: 1.4% of polyglycerol-3-methyl glucose distearate, 0.8% of glycerol stearate, 1.5% of isopropyl palmitate, 4% of caprylic/capric triglyceride, 4% of chinaroot greenbrier seed oil, 1% of polydimethylsiloxane, 0.02% of EDTA-2Na, 3% of glycerol, 5% of 1, 3-butanediol, 0.15% of carbomer, 0.09% of aminomethyl propanol, a proper amount of preservative, 5% of Chinese herbal compound fermentation liquor, a proper amount of essence and deionized water are added to 100%.
13. The cosmetic with the efficacy of controlling oil and removing acne according to claim 6, characterized in that:
the cosmetic is an oil-control acne-removing mask and comprises the following components in parts by mass: 2% of traditional Chinese medicine compound fermentation liquor, 5.00% of glycerol, 5.00% of 1, 3-propylene glycol, 0.10% of sodium hyaluronate, 0.10% of xanthan gum, 0.12% of hydroxyethyl cellulose, 0.60% of dipotassium glycyrrhizinate, 1.20% of aloe extract, 0.80% of 1, 2-hexanediol, 0.40% of p-hydroxyacetophenone and the balance of deionized water.
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| PCT/CN2018/099357 WO2020024314A1 (en) | 2018-08-02 | 2018-08-08 | Traditional chinese medicine compound fermentation liquid for cosmetics having mattifying and acne removal effects, and preparation therefor and application thereof |
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| CN109846744A (en) * | 2019-04-09 | 2019-06-07 | 广州昀东生物科技有限公司 | One Plant Extracts repair effect cosmetic |
| CN110200884B (en) * | 2019-06-19 | 2022-03-25 | 广州环亚化妆品科技有限公司 | Composition with oil control and repair effects, preparation method thereof and application thereof in cosmetics |
| CN112076141A (en) * | 2020-10-12 | 2020-12-15 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined enzyme for removing mites and acnes as well as preparation method and application thereof |
| CN115337233B (en) * | 2022-06-24 | 2023-05-30 | 广州环亚化妆品科技股份有限公司 | Gel mask with mild acne removing effect and preparation method thereof |
| CN117298029B (en) * | 2023-11-24 | 2024-01-30 | 广州伽能生物科技有限公司 | Composition with external comprehensive oil control effect and preparation method and application thereof |
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