CN108904376A - It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application - Google Patents
It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention disclose it is a kind of have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application, belong to cosmetic field.The Chinese medicine compound prescription fermentation liquid used for cosmetic is by including that the traditional Chinese medicinal components of following parts by weight are made：5~30 parts of loguat leaf, 5~25 parts of olive leaf, 5~25 parts of wild chrysanthemum, 5~20 parts of rhizoma imperatae, 5~20 parts of the sophora bud, 5~20 parts of kuh-seng, 5~25 parts of the coptis, 5~20 parts of Radix Glycyrrhizae.The present invention is that guidance carries out prescription with Chinese medicine monarch theory, is acted synergistically by plurality of Chinese, achievees the purpose that oil-control and anti-acne.Method of the invention uses fermentation extraction method, i.e., after Chinese medicine compound prescription mixture being carried out fermentation process, obtains Chinese medicine compound prescription fermentation liquid using filter, sterilizing and centrifugal separation.Chinese medicine compound prescription fermentation liquid of the invention can effectively reduce skin oil and fat secretion and removal whelk, and non-stimulated to skin safe, for having good oil-control and acne-removing in oil-control and acne-eliminating cosmetic.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound prescription fermentation liquids used for cosmetic, and particularly relating to one kind has effects that oil control and acne removal
Chinese medicine compound prescription fermentation liquid used for cosmetic and its preparation and application, belong to cosmetic field.
Background technique
Sebum be by skin inside sebaceous cell generate, and be secreted into the oil of skin surface.Hypersteatosis, meeting
Lead to glowing skin and generates uncomfortable sense of touch.The secreting function of the people of Oily, sebaceous glands are more vigorous, especially in the summer
It, the metabolism of human body itself can be accelerated, and intracorporal sweat gland, sebaceous gland activity can be reinforced, and the secretion of sebum can be added, not only
It will affect beauty, and excessive sebum accumulation, be also easy to cause some skin diseases, such as acne, acne, therefore controlled
Many greases of sauce secretion has certain necessity.
Currently, oil-control cosmetic on the market has very much, but mostly haves the defects that both effectiveness and safety：
1. the oil-control cosmetic of oil suction powder ingredient is added：Such oil-control cosmetic mainly using some oil suction powders at
Point, such as silica, titanium dioxide etc..These ingredients are to reduce from synthetic ingredient or mineralogical composition in addition to having in short-term
Outside the ability of fat secretion, it is difficult to have effects that control fat secretion for a long time, and be easier to cause cutaneous anaphylaxis.
2. the oil-control cosmetic of freshener is added：Freshener is mainly alcohol and peppermint, both there is moment pore refining
The effect of.But this cooling effect can only treat the symptoms, that is to say, that effect is restrained after the very short time can disappear, Wu Fayou
Effect controls the subsequent grease emerged.
3. the oil-control cosmetic of vitamin is added：Such oil-control cosmetic is using vitamin as grease conditioning ingredients, mainly
Object is the people that rouge leakage property dermatitis is caused due to a lack of vitamin B6, for suffering from the Oily of pimples, and is frequently accompanied by hair
The rouge leakage property oily skin of scorching phenomenon, the oil-control product of selection collocation vitamin B6, vitamin B3 and biotin, compared with can obtain
The effect effected a permanent cure.But the people of general Oily, it might not be effective using such oil-control cosmetic.
Summary of the invention
In order to overcome the disadvantages and deficiencies of the prior art, the primary purpose of the present invention is that providing a kind of with oil control and acne removal
The Chinese medicine compound prescription fermentation liquid used for cosmetic of effect.The Chinese medicine compound prescription fermentation liquid used for cosmetic have it is preferable reduce fat secretion and
Persistently the effect of control fat secretion, and safety with higher.
Another object of the present invention is to provide a kind of above-mentioned Chinese medicine compound prescription used for cosmetic hairs with oil control and acne removal
The preparation method of zymotic fluid.
A further object of the present invention is to provide a kind of above-mentioned Chinese medicine compound prescription used for cosmetic hairs with oil control and acne removal
The application of zymotic fluid.
The purpose of the invention is achieved by the following technical solution：
It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by the Chinese medicine group including following parts by weight
Divide and is made：It is 5~30 parts of loguat leaf, 5~25 parts of olive leaf, 5~25 parts of wild chrysanthemum, 5~20 parts of rhizoma imperatae, 5~20 parts of the sophora bud, bitter
5~20 parts, 5~25 parts of the coptis, 5~20 parts of Radix Glycyrrhizae of ginseng.
Preferably, described to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by including following weight
The traditional Chinese medicinal components of part are made：10~20 parts of loguat leaf, 10~15 parts of olive leaf, 10~12 parts of wild chrysanthemum, 10~15 parts of rhizoma imperatae,
10~15 parts of the sophora bud, 10~15 parts of kuh-seng, 10~15 parts of the coptis, 10~15 parts of Radix Glycyrrhizae.
Preferably, described to have effects that the Chinese medicine compound prescription fermentation liquid (I) used for cosmetic of oil control and acne removal, by including following heavy
The traditional Chinese medicinal components of amount part are made：10 parts of loguat leaf, 15 parts of olive leaf, 10 parts of wild chrysanthemum, 10 parts of rhizoma imperatae, 15 parts of the sophora bud, kuh-seng
15 parts, 10 parts of the coptis, 15 parts of Radix Glycyrrhizae.
Preferably, described to have effects that the Chinese medicine compound prescription fermentation liquid (II) used for cosmetic of oil control and acne removal, by including following
The traditional Chinese medicinal components of parts by weight are made：It is 15 parts of loguat leaf, 10 parts of olive leaf, 12 parts of wild chrysanthemum, 12 parts of rhizoma imperatae, 11 parts of the sophora bud, bitter
15 parts, 12 parts of the coptis, 13 parts of Radix Glycyrrhizae of ginseng.
Preferably, described to have effects that the Chinese medicine compound prescription fermentation liquid (III) used for cosmetic of oil control and acne removal, by including following
The traditional Chinese medicinal components of parts by weight are made：It is 20 parts of loguat leaf, 10 parts of olive leaf, 10 parts of wild chrysanthemum, 15 parts of rhizoma imperatae, 10 parts of the sophora bud, bitter
10 parts, 15 parts of the coptis, 10 parts of Radix Glycyrrhizae of ginseng.
Preferably, compound bacteria used in the fermentation is lactobacillus plantarum and S. cervisiae；
Preferably, lactobacillus plantarum and S. cervisiae be in proportion (1~6) in the compound bacteria：1 composition, compound bacteria
Liquid concentration is 106~108cfu/mL。
The second object of the present invention, which is to provide, above-mentioned has effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal
Preparation method.
In order to which the fermentation liquid is made, present invention employs fermentation extraction methods, i.e., send out Chinese medicine compound prescription mixture
After ferment processing, Chinese medicine compound prescription fermentation liquid is obtained using filter, sterilizing and centrifugal separation.Specifically comprise the following steps：
1. compound bacteria is added in the form of bacterium solution, the composite bacteria liquid be lactobacillus plantarum and S. cervisiae in proportion
(1~6)：1 composition, composite bacteria liquid concentration are 106~108cfu/mL；
2. stocking up：By the removal of impurities of each Chinese medicine material, cleaning, drying, 40~200 mesh are crushed to, are mixed, it is mixed to obtain Chinese medicine compound prescription
Close object；Compound concentration is 106~108The composite bacteria liquid of cfu/mL, pH value are adjusted to 6.5~7.5；
3. fermenting：Composite bacteria liquid, Chinese medicine compound prescription mixture and water are mixed according to the ratio, in 28~42 DEG C, 50~300r/
It ferments 36~48 hours in min condition, obtains fermentation liquid；
4. purifying：By gained filtering fermentation liquor, filtrate makes in 105~120 DEG C of at a temperature of 20~35min of high pressure sterilization
Strain inactivation；Ferment filtrate after sterilizing is centrifuged 20 under conditions of 3000~8000r/min, centrifugation radius are 5~20cm
~35min abandons precipitating, collects supernatant, is concentrated with film, concentrate macroporous resin adsorption, then with volume fraction for 10~
95% ethyl alcohol repeatedly elutes, and collects eluent, and film is concentrated into the concentrate with Chinese medicine compound prescription mixture identical weight, adds
It is dissolved with the butanediol of concentrate identical weight, filtering, as has effects that the Chinese medicine compound prescription used for cosmetic fermentation of oil control and acne removal
Liquid.
Preferably, step 1. described in composite bacteria liquid be lactobacillus plantarum and S. cervisiae in proportion 3：1 composition；
Preferably, step 2. in, be crushed to 80 mesh.
Preferably, step 3. in, ferment 40 hours in 30~35 DEG C, 100r/min condition, obtain fermentation liquid；
The amount ratio of the composite bacteria liquid, Chinese medicine compound prescription mixture and water is 20mL~60mL：20g~60g：200~
600g。
Preferably, the amount ratio of the composite bacteria liquid, Chinese medicine compound prescription mixture and water is 35mL~45mL：35g~
50g：300~400g.
Preferably, the Chinese medicine compound prescription fermentation liquid (I), the amount ratio of composite bacteria liquid, Chinese medicine compound prescription mixture and water are
40mL：40g：300g.
Preferably, the Chinese medicine compound prescription fermentation liquid (II), the amount ratio of composite bacteria liquid, Chinese medicine compound prescription mixture and water are
45mL：50g：400g.
Preferably, the Chinese medicine compound prescription fermentation liquid (III), the amount ratio of composite bacteria liquid, Chinese medicine compound prescription mixture and water are
35mL：35g：300g.
Preferably, step 4. described in centrifugation radius be 8~12cm.
Preferably, step 4. in, filtrate inactivates strain in 105~120 DEG C of at a temperature of high pressure sterilization 30min；It will go out
Ferment filtrate after bacterium is centrifuged 30min under conditions of 4000r/min, centrifugation radius are 10cm, abandons precipitating, collects supernatant.
Third object of the present invention is that this kind being had effects that, the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal is answered
A kind of have effects that the cosmetics of oil control and acne removal for providing in cosmetics.
In order to reach this purpose of the invention, this invention takes following technical solutions：
A kind of Chinese medicine compound prescription fermentation liquid used for cosmetic with oil control and acne removal is described in the application prepared in cosmetics
Have effects that additive amount of the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal in cosmetics be based on mass fraction 0.1~
20%.
Have effects that the cosmetics of oil control and acne removal the present invention also provides a kind of, which contains above-mentioned with oil control and acne removal
The Chinese medicine compound prescription fermentation liquid used for cosmetic of effect.
Preferably, which, which contains, above-mentioned has effects that the change of oil control and acne removal based on mass fraction for 0.1~20%
Cosmetic Chinese medicine compound prescription fermentation liquid.
The cosmetics are：Aqua, type of latex type, cream kind, gel class, powder class, powder compacting class, facial mask, spray-like,
Essence class washes shield class.
Specifically, the present invention provides a kind of oil control and acne removal toner, the component including following mass fraction meter：
| Material name | Mass fraction/% |
| Deionized water | Add to 100 |
| EDTA-2Na | 0.02 |
| Glycerol | 5 |
| Panthenol | 0.2 |
| 1,3 butylene glycol | 5 |
| Sodium Hyaluronate | 0.05 |
| Preservative | In right amount |
| Chinese medicine compound prescription fermentation liquid of the present invention | 5 |
| Essence | In right amount |
Specifically, the present invention provides a kind of oil control and acne removal skin care milk, the component including following mass fraction meter：
Specifically, the present invention provides a kind of oil control and acne removal facial mask, the component including following mass fraction meter：
| Component | Mass fraction/% |
| Chinese medicine compound prescription fermentation liquid of the invention | 5 |
| Glycerol | 5.00 |
| 1,3- propylene glycol | 5.00 |
| Sodium Hyaluronate | 0.10 |
| Xanthan gum | 0.10 |
| Hydroxyethyl cellulose | 0.12 |
| Dipotassium glycyrrhizinate | 0.60 |
| Aloe extract | 1.20 |
| 1,2- hexylene glycol | 0.80 |
| Parahydroxyacet-ophenone | 0.40 |
| Deionized water | Surplus |
Mechanism of the invention is：
Traditional Chinese medicine beautifying theory thinks, good skin not only needs external modification, it is often more important that skin is from inside to outside
Health.Chinese medicine thinks that acne is formed mostly because blood-head, blood-deficiency and wind-dry, heat toxin, wet etc. cause, so treatment small pox common method is also
Set about from heat of dispelling, toxic removing, clearing damp.
The present invention is that guidance carries out prescription with Chinese medicine monarch theory, and using loguat leaf as monarch drug in a prescription, loguat leaf has heat-clearing
The effect of removing toxic substances, preventing phlegm from forming and stopping coughing, while there is good antibacterial, control fat secretion effect；Wild chrysanthemum, rhizoma imperatae, the sophora bud are common
For ministerial drug, wild chrysanthemum has effects that clearing heat and detoxicating, wind-dispelling heat-dissipating, dissipates the stasis of blood, and rhizoma imperatae has effects that cooling blood and hemostasis, reducing fever and causing diuresis,
The sophora bud has effects that cooling blood and hemostasis, clearing liver fall fire and anti-inflammatory, antioxidation；Kuh-seng, olive leaf and the coptis are adjutant jointly, bitter
Ginseng has effects that heat-clearing and damp-drying drug, desinsection, diuresis and good antibacterial action, and olive leaf has broad-spectrum antibacterial action and well anti-oxidant
Effect, coptis heat-clearing and damp-drying drug, purging fire for removing toxin effect and good antibacterial action；Radix Glycyrrhizae is to make medicine, is had clearing heat and detoxicating, anti-inflammatory, anti-
Free radical and other effects has the function of coordinating the drug actions of a prescription.The above all medicines share, this strong solid member, nourishes conditioning, with heat of dispelling, toxic removing, dispels
Wet is anti-acne sheet；The mark of antipollution is turned to anti-inflammatory, sterilization, antioxygen.It is very good that Chinese medicine compound prescription fermentation liquid of the invention has
Oil-control, the comprehensive effect such as antibacterial, anti-oxidant, make an addition in acne-eliminating cosmetic, acne-removing is significant.
The present invention has the following advantages and effects with respect to the prior art：
The present invention is that guidance carries out prescription with Chinese medicine monarch theory, is acted synergistically by plurality of Chinese, from oil-control, suppression
Achieve the purpose that oil-control and anti-acne in terms of the comprehensive effect such as bacterium, anti-oxidant.Preparation method of the invention uses fermentation extraction method,
After Chinese medicine compound prescription mixture is carried out fermentation process, Chinese medicine compound prescription fermentation liquid is obtained using filter, sterilizing and centrifugal separation.This
The Chinese medicine compound prescription fermentation liquid of invention can effectively reduce skin oil and fat secretion and removal whelk, and non-stimulated to skin safe, use
In oil-control and acne-eliminating cosmetic, there is good oil-control and acne-removing.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
The test method of specific experiment condition is not specified in the following example, usually according to conventional laboratory conditions or according to system
Make experiment condition proposed by factory.
Lactobacillus plantarum used in embodiment (Lactobacillus plantarum), adds biology purchased from Changzhou beneficial bacteria
Science and Technology Ltd., model NJ2205；
S. cervisiae used in embodiment (Saccharomyces cerevisiae) is purchased from the triumphant microorganism of Guangdong ring
Science and Technology Ltd., model ATCC9763；
Propionibacterium acnes used in embodiment (Propionibacterium acnes) are purchased from the triumphant micro- life of Guangdong ring
Object Science and Technology Ltd., model GIM1.162.
Embodiment 1 is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid (I) used for cosmetic of oil control and acne removal
It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by the Chinese medicine group including following parts by weight
Divide and is made：10 parts of loguat leaf, 15 parts of olive leaf, 10 parts of wild chrysanthemum, 10 parts of rhizoma imperatae, 15 parts of the sophora bud, 15 parts of kuh-seng, the coptis 10
Part, 15 parts of Radix Glycyrrhizae.
Preparation method is as follows：
1. compound bacteria is added in the form of bacterium solution, the composite bacteria liquid be lactobacillus plantarum and S. cervisiae in proportion
3：1 composition, composite bacteria liquid concentration are 106~108cfu/mL。
2. stocking up：By the removal of impurities of each Chinese medicine material, cleaning, drying, 80 mesh are crushed to, mixes, obtains Chinese medicine compound prescription mixture；
Compound concentration is 106~108The composite bacteria liquid of cfu/mL, pH value are adjusted to 6.5~7.5.
3. fermenting：Composite bacteria liquid, Chinese medicine compound prescription mixture and water are mixed according to the ratio, in 30~35 DEG C, 100r/min
It ferments 40 hours in shaking table, obtains fermentation liquid.
4. purifying：By gained filtering fermentation liquor, filtrate makes strain in 105~120 DEG C of at a temperature of high pressure sterilization 30min
Inactivation.Ferment filtrate after sterilizing is centrifuged 30min under conditions of 4000r/min, centrifugation radius are 10cm, precipitating is abandoned, receives
Collect supernatant, is concentrated with film, (AB-8 macroporous absorbent resin has concentrate purchased from Tianjin pula moral biotechnology with macroreticular resin
Limit company) absorption, then repeatedly eluted with the ethyl alcohol that volume fraction is 10~95%, eluent is collected, film is concentrated into multiple with Chinese medicine
The concentrate of square mixture identical weight is added and is dissolved with the butanediol of concentrate identical weight, and filtering, as the present invention mentions
The Chinese medicine compound prescription fermentation liquid (I) of confession.
The amount ratio of the composite bacteria liquid, Chinese medicine compound prescription mixture and water is 40mL：40g：300g.
Embodiment 2 is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid (II) used for cosmetic of oil control and acne removal
It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by the Chinese medicine group including following parts by weight
Divide and is made：15 parts of loguat leaf, 10 parts of olive leaf, 12 parts of wild chrysanthemum, 12 parts of rhizoma imperatae, 11 parts of the sophora bud, 15 parts of kuh-seng, the coptis 12
Part, 13 parts of Radix Glycyrrhizae.
Preparation method is in addition to " amount ratio of composite bacteria liquid, Chinese medicine compound prescription mixture and water is 45mL：50g：400g " outside,
It is remaining consistent with embodiment 1, Chinese medicine compound prescription fermentation liquid (II) provided by the invention is made.
Embodiment 3 is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid (III) used for cosmetic of oil control and acne removal
It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by the Chinese medicine group including following parts by weight
Divide and is made：20 parts of loguat leaf, 10 parts of olive leaf, 10 parts of wild chrysanthemum, 15 parts of rhizoma imperatae, 10 parts of the sophora bud, 10 parts of kuh-seng, the coptis 15
Part, 10 parts of Radix Glycyrrhizae.
Preparation method is in addition to " amount ratio of composite bacteria liquid, Chinese medicine compound prescription mixture and water is 35mL：35g：300g " outside,
It is remaining consistent with embodiment 1, Chinese medicine compound prescription fermentation liquid (III) provided by the invention is made.
1~8 single medicinal material fermentation liquid of comparative example
Weigh 100 parts of Chinese medicine loguat leaf respectively, 100 parts of olive leaf, 100 parts of wild chrysanthemum, 100 parts of rhizoma imperatae, the sophora bud 100
Part, 100 parts of kuh-seng, 100 parts of the coptis, 100 parts of Radix Glycyrrhizae.Fermentation extraction is carried out according to preparation method described in embodiment 1, is successively divided
It Zhi get not single medicinal material fermentation liquid.
9 traditional Chinese medicine compound extract of comparative example
According to the consistent Chinese medicine compound prescription amount of mixture of embodiment 1, i.e., Chinese medicine compound prescription mixture by include following weight
Chinese medicine component be made：10 parts of loguat leaf, 15 parts of olive leaf, 10 parts of wild chrysanthemum, 10 parts of rhizoma imperatae, 15 parts of the sophora bud, kuh-seng 15
Part, 10 parts of the coptis, 15 parts of Radix Glycyrrhizae.
Preparation method：By the removal of impurities of each Chinese medicine material, cleaning, drying, 100 mesh are crushed to, are 8 by liquid material mass ratio:1 is added
Deionized water after impregnating 2.5h, carries out room temperature extraction with high pressure homogenization method machine in the case where 60MPa extracts pressure, extracting solution through from
It after heart separation, is concentrated with film, concentrate macroporous resin adsorption, then is repeatedly eluted with the ethyl alcohol that volume fraction is 10~95%,
Eluent is collected, film is concentrated into the concentrate with Chinese medicine identical weight, and it adds and is dissolved with the butanediol of concentrate identical weight,
Traditional Chinese medicine compound extract is made in filtering.
Test example 1 inhibits propionibacterium acnes efficacy assessments
1, the preparation of Chinese medical extract sample
A kind of have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and comparative example 1 for prepared by embodiment 1
~8 preparation single medicinal material fermentation liquid, comparative example 9 prepare traditional Chinese medicine compound extract be formulated as mass fraction be 0.5%,
1.0%, 1.5%, 2.0,3.0% sample aqueous solution, it is spare.
2, to the test method of propionibacterium acnes rejection ability
It respectively takes 10 kinds of sample aqueous solution 1mL to be added separately in sterile glass test tube, topples over the previously prepared improvement of 8mL respectively
GAM broth bouillon (Japanese Nissui, number ZZM-05433).Taking-up has divided pure and in 35 DEG C of constant temperature CO2Incubator culture
The clinical propionibacterium acnes of 48h take the injection of 1mL bacteria suspension that the improvement GAM broth bouillon of sample aqueous solution has been added to try respectively
Guan Zhong does negative control with a teat glass without bacteria suspension.Every kind of sample culturing base successively connects since low concentration
Kind propionibacterium acnes, are placed in 35 DEG C of constant temperature CO as early as possible after inoculation2Incubator culture 48h.After culture, improvement GAM meat is first extracted
Liquid in soup culture medium carries out preliminary identification experiment, then is reflected by VITEK full automatic microorganism analysis system, ANI anaerobic bacteria
It is fixed to block the killing situation for determining propionibacterium acnes, as a result as shown in table 1 below.
The killing situation of 1 propionibacterium acnes of table
Embodiment 1 shows Chinese medicine compound prescription fermentation liquid prepared by the present invention to acne propionic acid with 1~8 comparing result of comparative example
Bacillus has obvious inhibitory effect, more much better than single medicinal material fermentation liquid effect prepared by comparative example 8, illustrates the Chinese medicine after compound
It acts synergistically between component significant.In addition, the fungistatic effect of embodiment 1 is substantially better than comparative example 9, illustrate that Chinese medicine compound prescription mixture passes through
After everfermentation, bacteriostasis efficacy is remarkably reinforced.
The experiment of 2 oil-control efficacy assessments of test example
1, test principle
Using the fat content of grease tester Sebumeter SM815 test skin.It is to be based on photometer principle, one
After the special delustring adhesive tape absorption grease on human skin of kind of 0.1mm thickness, a kind of translucent adhesive tape just will become, it saturating
Light quantity will change, and the grease of absorption is more, and light transmission capacity will be bigger, can thus measure containing for skin oil and fat
Amount.
2, test apparatus：
Sebumeter SM815 (German Courage+Khazaha company)
3, test specimen
Test specimen #1~#3 includes prepared by the component of 2 mass percent of table such as.
The component of 2 test specimen #1~#3 of table
| Material name | #1 | #2 | #3 |
| Deionized water | Surplus | Surplus | Surplus |
| EDTA-2Na | 0.02% | 0.02% | 0.02% |
| Glycerol | 5% | 5% | 5% |
| Panthenol | 0.2% | 0.2% | 0.2% |
| 1,3 butylene glycol | 8% | 8% | 8% |
| Sodium Hyaluronate | 0.05% | 0.05% | 0.05% |
| Preservative | In right amount | In right amount | In right amount |
| Fermentation liquid described in embodiment 1 | 5% | / | / |
| Extracting solution described in comparative example 9 | / | 5% | / |
Preparation method is as follows：
(1) by raw material deionized water, EDTA-2Na, glycerol, panthenol is mixed and is heated to 80 DEG C, and stirring is to transparent molten
Solution is complete；
(2) by raw material 1,3-BDO, after Sodium Hyaluronate is mixed and stirred for uniformly at normal temperature, it is added to step (1)
In resulting solution, 80 DEG C keep the temperature 10 minutes, are stirred until homogeneous；
(3) stirring is cooled to 45 DEG C, and surplus stock is added, stirs evenly；
(4) vacuum defoamation, 38 DEG C with bottom discharge, Material is aqueous solution.
#1~#3 sample is made respectively by preparation method, wherein #2~#3 is contrast sample, in addition, selecting one in the market
Money sales volume is preferable and declares the cosmetics with oil control and acne removal, and Material is fitted into sample bottle, is designated as #4 sample, same to make
For contrast sample.
4, subjects
1. the age is at Oily volunteer totally 180 of 20~40 years old；
2. recipient site did not receive skin without serious systemic disease, without immune deficiency or autoimmune disease person
Treatment, beauty and other may influence the test of result；No active anaphylactia person；Without the highly sensitive person of constitution；Closely
Hormone medicine and immunosuppressor person are not used in January；Present or nearest three months recipient sites do not participate in other clinics
Experimenter.
5, test method
Subject is randomly divided into 3 groups, every group 30, group number is denoted as #1~#2, #4.Subject is in temperature 22 ± 3
DEG C, it sits quietly in the laboratory of relative humidity 50 ± 5% 30 minutes, tests a left side respectively with grease tester Sebumeter SM815
The skin oil and fat content of right forehead, is denoted as the data of D0, the sample of sample #3 and each group reference numeral is distributed to each tested
Person and guides subject to carry out the comparison of half face and tries out, and two kinds of samples are smeared respectively and are used in left half face or right half face, primary each
It smears sample 0.5g and once in the morning and once at night continues 28 days, and returned constant temperature laboratory at the 14th day and the 28th day respectively and test skin
Skin fat content, data are denoted as D14 and D28.The fat content change rate of D14 and D28 is calculated separately out as follows：
Fat content change rate=(using fat content before sample using fat content-after sample)/using oil before sample
Rouge content } × 100%
(4) experimental result：
The results are shown in Table 3.
3 fat content change rate of table
| Test sample | D14 grease change rate (%) | D28 grease change rate (%) |
| Sample #1 | - 23.9% | - 39.6% |
| Sample #2 | -17.4 | - 29.6% |
| Sample #4 | - 12.5% | - 20.3% |
The results show that using the laboratory sample #1 for being added to fermentation liquid prepared by embodiment 1 in the present invention, at 14 days, skin
Skin fat content is decreased obviously, and persistently using after 28 days, effect is more obvious, and continues to use the extracting solution system containing comparative example 9
Standby laboratory sample #2, oil-control effect are obviously not so good as sample #1, illustrate that Chinese medicine compound prescription acne-removing is shown after everfermentation
Write enhancing.And the oil-control effect of sample #1, #2 are more much better than than sample #4, illustrate that Chinese medicine compound prescription of the invention has significant control
Oily effect.
3 irritation evaluation experimental of test example
Fermentation liquid irritation is evaluated using rabbit erythrocyte hemolytic experiment.Concrete operations are as follows：Example 1 and comparison respectively
500 μ L of fermentation liquid prepared by example 1~8 is placed in 2mL centrifuge tube, then is separately added into 2% rabbit erythrocyte (commercially available) suspension, 500 μ L,
Jog mixes, and is placed in 37 DEG C of constant incubators after incubating 3h, and 2000r/min is centrifuged 3min, Aspirate supernatant, with physiological saline
Light absorption value is measured at wavelength 414nm, haemolysis degree is calculated by formula using distilled water as positive control for negative control.As a result such as
Shown in table 4.
4 haemolysis degree result of table
Embodiment 1 shows Chinese medicine compound prescription fermentation liquid haemolysis ratio ratio of the invention with the comparison of 1~8 experimental result of comparative example
The fermentation liquid of single medicinal material made from comparative example 1~8 is much lower, significantly reduces by the irritation of compound post-fermentation liquid.
1 oil control and acne removal toner of Application Example
Contain a kind of oil control and acne removal toner with the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, formula
It is shown in Table 5.
5 oil control and acne removal toner formula of table
| Material name | Mass fraction/% |
| Deionized water | Add to 100 |
| EDTA-2Na | 0.02 |
| Glycerol | 5 |
| Panthenol | 0.2 |
| 1,3 butylene glycol | 5 |
| Sodium Hyaluronate | 0.05 |
| Preservative | In right amount |
| Chinese medicine compound prescription fermentation liquid (I) of the present invention | 5 |
| Essence | In right amount |
Preparation method is as follows：
(1) by raw material deionized water, EDTA-2Na, glycerol, panthenol is mixed and is heated to 80 DEG C, and stirring is to transparent molten
Solution is complete；
(2) by raw material 1,3-BDO, after Sodium Hyaluronate is mixed and stirred for uniformly at normal temperature, it is added to step (1)
In resulting solution, 80 DEG C keep the temperature 10 minutes, are stirred until homogeneous；
(3) stirring is cooled to 45 DEG C, and surplus stock is added, stirs evenly；
(4) vacuum defoamation, 38 DEG C with bottom discharge, Material is aqueous solution.
2 oil control and acne removal skin care milk of Application Example
Contain a kind of oil control and acne removal skin care milk with the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, formula
It is shown in Table 6.
6 oil control and acne removal skin care milk formula of table
| Material name | Mass fraction/% |
| Polyglycereol-3-methyl distearate | 1.4 |
| Stearine | 0.8 |
| Isopropyl palmitate | 1.5 |
| Caprylic/capric triglyceride | 4 |
| White pond flower seed oil | 4 |
| Dimethyl silicone polymer | 1 |
| Deionized water | Add to 100 |
| EDTA-2Na | 0.02 |
| Glycerol | 3 |
| 1,3 butylene glycol | 5 |
| Carbomer (CA) | 0.15 |
| Aminomethyl propanol | 0.09 |
| Preservative | In right amount |
| Chinese medicine compound prescription fermentation liquid (I) of the present invention | 5 |
| Essence | In right amount |
Specific preparation method is as follows：
(1) by raw material deionized water, EDTA-2Na, glycerol, 1,3-BDO, carbomer (CA) mixing is heated to 80
DEG C, heat preservation for standby use；
(2) by raw material polyglycereol-3-methyl distearate, stearine, isopropyl palmitate, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, white pond flower seed oil, dimethyl silicone polymer are mixed and stirred for being heated to 80 DEG C, until quickly adding after dissolution completely
Enter into step (1) resulting solution, with speed homogeneous 15 minutes of 3000 revs/min；
(3) when being cooled to 45 DEG C, surplus stock is added, stirs evenly；
(4) vacuum defoamation discharges when being down to 38 DEG C, and Material is emulsion.
3 oil control and acne removal facial mask of Application Example
A kind of oil control and acne removal face pack prescription containing Chinese medicine compound prescription fermentation liquid of the invention is shown in Table 7.
7 oil control and acne removal face pack prescription of table
| Component | Mass fraction/% |
| Chinese medicine compound prescription fermentation liquid (I) of the invention | 5 |
| Glycerol | 5.00 |
| 1,3- propylene glycol | 5.00 |
| Sodium Hyaluronate | 0.10 |
| Xanthan gum | 0.10 |
| Hydroxyethyl cellulose | 0.12 |
| Dipotassium glycyrrhizinate | 0.60 |
| Aloe extract | 1.20 |
| 1,2- hexylene glycol | 0.80 |
| Parahydroxyacet-ophenone | 0.40 |
| Deionized water | Surplus |
Preparation method is as follows：
(1) xanthan gum and Sodium Hyaluronate are dispersed in advance in glycerol, then with dipotassium glycyrrhizinate, hydroxy ethyl fiber
Element, Chinese medicine compound prescription fermentation liquid (I) are put into deionized water together, and stirring and dissolving is transparent to being uniformly dispersed；
(2) parahydroxyacet-ophenone is dissolved by heating in 1,3-PD and 1,2- hexylene glycol in advance, investment to step (1)
In the solution, stirring and dissolving is uniform；
(3) aloe extract is put into again, is evenly stirred until and is completely dissolved；
(4) color, pH, fragrance, the physical and chemical indexes such as appearance, after the assay was approved 200 mesh filtering and discharging are examined.
1 anti-acne effect of effect example, oil-control effect and skin irritation evaluation
Evaluation object：Selecting face to have acne, age is young man 30 of 15~30 years old, wherein male 15, women
15.
Evaluation method：Using double-blind study, face is applied with oil control and acne removal facial mask prepared by Application Example 3 sooner or later daily, is removed
Face is massaged after facial mask until facial mask liquid is all absorbed by the skin.
Evaluate the course for the treatment of：Anti-acne effect evaluation is with 20 days as a treatment course, and oil-control effect assessment is with 28 days as a treatment course, thorn
Property evaluation is swashed with 20 days as a treatment course.
Anti-acne effect evaluation criterion：1. effective：70% or more acne fading；2. effectively：30% or more acne fading；3. nothing
Effect：30% or less acne fading.
Oil-control effect assessment standard：It is consistent described in test method and test example 2.
Irritation evaluation criterion：It is checked according to 8 standard of table.It has carried out testing for 20 days altogether.
8 irritation evaluation criterion of table
| Grade | Standard of perfection |
| 0 | Negative reaction：It is non-stimulated, without erythema |
| 1 | Suspicious reaction：Slight erythema |
| 2 | Weakly positive reaction：Erythema |
| 3 | Strong positive reaction：Erythema, papule, blister |
| 4 | Extremely strong positive reaction：Serious edema, bulla |
Anti-acne effect evaluation result：Effective 15, account for 50%；Effective 7, account for 23.3%；Invalid 8, account for 26.7%.Always
Effective percentage reaches 73.3%, illustrates that Chinese medicine compound prescription fermentation liquid of the present invention has good anti-acne effect.
Oil-control effect assessment result：Volunteer's skin oil and fat slip is 41.6% after 28 days, illustrates that Application Example 3 is made
Standby oil control and acne removal facial mask has good oil-control effect.
Irritation evaluation result：Allergic phenomena is not found in all volunteers.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, it is characterised in that：Described is used for cosmetic
Chinese medicine compound prescription fermentation liquid is by including that the traditional Chinese medicinal components of following parts by weight are made：5~30 parts of loguat leaf, 5~25 parts of olive leaf, mother chrysanthemum
Spend 5~25 parts, 5~20 parts of rhizoma imperatae, 5~20 parts of the sophora bud, 5~20 parts of kuh-seng, 5~25 parts of the coptis, 5~20 parts of Radix Glycyrrhizae.
2. according to claim 1 have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, it is characterised in that：
Described has effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, by the traditional Chinese medicinal components including following parts by weight
It is made：10~20 parts of loguat leaf, 10~15 parts of olive leaf, 10~12 parts of wild chrysanthemum, 10~15 parts of rhizoma imperatae, the sophora bud 10~15
Part, 10~15 parts of kuh-seng, 10~15 parts of the coptis, 10~15 parts of Radix Glycyrrhizae.
3. according to claim 1 or 2 have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal, feature exists
In：Compound bacteria used in the fermentation is lactobacillus plantarum and S. cervisiae；
Lactobacillus plantarum and S. cervisiae be in proportion (1~6) in the compound bacteria：1 composition, composite bacteria liquid concentration are 106~
108cfu/mL。
4. the described in any item preparations with the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal of claims 1 to 3
Method, it is characterised in that：
Using fermentation extraction method, i.e., after Chinese medicine compound prescription mixture being carried out fermentation process, using filter, sterilizing and centrifugal separation
Obtain Chinese medicine compound prescription fermentation liquid；
Specifically comprise the following steps：
1. compound bacteria is added in the form of bacterium solution, the composite bacteria liquid be lactobacillus plantarum and S. cervisiae in proportion (1~
6)：1 composition, composite bacteria liquid concentration are 106~108cfu/mL；
2. stocking up：By the removal of impurities of each Chinese medicine material, cleaning, drying, 40~200 mesh are crushed to, are mixed, Chinese medicine compound prescription mixing is obtained
Object；Compound concentration is 106~108The composite bacteria liquid of cfu/mL, pH value are adjusted to 6.5~7.5；
3. fermenting：Composite bacteria liquid, Chinese medicine compound prescription mixture and water are mixed according to the ratio, in 28~42 DEG C, 50~300r/min item
It ferments 36~48 hours in part, obtains fermentation liquid；
4. purifying：By gained filtering fermentation liquor, filtrate makes strain in 105~120 DEG C of at a temperature of 20~35min of high pressure sterilization
Inactivation；By the ferment filtrate after sterilizing 3000~8000r/min, centrifugation radius be 5~20cm under conditions of centrifugation 20~
35min, abandon precipitating, collect supernatant, be concentrated with film, concentrate macroporous resin adsorption, then with volume fraction be 10~95%
Ethyl alcohol repeatedly elute, collect eluent, film is concentrated into the concentrate with Chinese medicine compound prescription mixture identical weight, add with it is dense
The butanediol of contracting liquid identical weight dissolves, and filtering as has effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal.
5. the preparation method with the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal according to claim 4,
It is characterized in that：
The amount ratio of the composite bacteria liquid, Chinese medicine compound prescription mixture and water is 20mL~60mL：20g~60g：200~600g；
Step 1. described in composite bacteria liquid be lactobacillus plantarum and S. cervisiae in proportion 3：1 composition；
Step 3. in, ferment 40 hours in 30~35 DEG C, 100r/min condition, obtain fermentation liquid.
6. prepared by the described in any item Chinese medicine compound prescription fermentation liquids used for cosmetic with oil control and acne removal of claims 1 to 3
Application in cosmetics.
7. application according to claim 6, it is characterised in that：
Described has effects that additive amount of the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal in cosmetics with quality point
Number is calculated as 0.1~20%.
8. a kind of have effects that the cosmetics of oil control and acne removal, it is characterised in that：Contain the described in any item tools of claims 1 to 3
There is the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal effect.
9. according to claim 8 have effects that the cosmetics of oil control and acne removal, it is characterised in that：
The cosmetics, which contain, has effects that the Chinese medicine compound prescription used for cosmetic of oil control and acne removal based on mass fraction for 0.1~20%
Fermentation liquid；
The cosmetics are：Aqua, type of latex type, cream kind, gel class, powder class, powder compacting class, facial mask, spray-like, essence
Class washes shield class.
10. according to claim 8 or claim 9 have effects that the cosmetics of oil control and acne removal, it is characterised in that：
The cosmetics are oil control and acne removal toner, the component including following mass fraction meter：
The cosmetics are oil control and acne removal skin care milk, the component including following mass fraction meter：
The cosmetics are oil control and acne removal facial mask, the component including following mass fraction meter：
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| CN201810870369.6A CN108904376B (en) | 2018-08-02 | 2018-08-02 | Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof |
| PCT/CN2018/099357 WO2020024314A1 (en) | 2018-08-02 | 2018-08-08 | Traditional chinese medicine compound fermentation liquid for cosmetics having mattifying and acne removal effects, and preparation therefor and application thereof |
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|---|---|---|---|
| CN201810870369.6A CN108904376B (en) | 2018-08-02 | 2018-08-02 | Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof |
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| CN109846744A (en) * | 2019-04-09 | 2019-06-07 | 广州昀东生物科技有限公司 | One Plant Extracts repair effect cosmetic |
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| CN113143835A (en) * | 2020-10-12 | 2021-07-23 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined enzyme for removing mites and acnes as well as preparation method and application thereof |
| CN115337233A (en) * | 2022-06-24 | 2022-11-15 | 广州环亚化妆品科技股份有限公司 | Gel mask with mild acne removing effect and preparation method thereof |
| CN117298029A (en) * | 2023-11-24 | 2023-12-29 | 广州伽能生物科技有限公司 | Composition with external comprehensive oil control effect and preparation method and application thereof |
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| CN113143835A (en) * | 2020-10-12 | 2021-07-23 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined enzyme for removing mites and acnes as well as preparation method and application thereof |
| CN113143835B (en) * | 2020-10-12 | 2022-08-23 | 中华全国供销合作总社南京野生植物综合利用研究所 | Plant combined enzyme for removing mites and acnes as well as preparation method and application thereof |
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| CN117298029A (en) * | 2023-11-24 | 2023-12-29 | 广州伽能生物科技有限公司 | Composition with external comprehensive oil control effect and preparation method and application thereof |
| CN117298029B (en) * | 2023-11-24 | 2024-01-30 | 广州伽能生物科技有限公司 | Composition with external comprehensive oil control effect and preparation method and application thereof |
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| CN108904376B (en) | 2020-07-10 |
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