CN107737062A - A kind of hyaluronic acid BB frosts and preparation method with multi-efficiency - Google Patents
A kind of hyaluronic acid BB frosts and preparation method with multi-efficiency Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention provide it is a kind of with multi-efficiency hyaluronic acid BB frost, said composition including following weight than component：Hyaluronic acid 0.01 3.0%, non-plant sucrose clear cream 1.0 5.0%, function compound 0.5 3.5%, matrix auxiliary material 89.0 98.4%；Wherein, non-plant sucrose clear cream：Eight kinds of element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel active plants are slided by aloe silk to mix system with sucrose solution and match somebody with somebody；Wherein, function compound：System is mixed in proportion by niacinamide, allantoin and polyglutamic acid to match somebody with somebody.The present invention, which not only has, hides the flaw, the adjustment colour of skin, the basic effect of sun-proof, careful pore, also there is the multi-efficiency such as moisturizing, skin lightening, antiallergic, anti-inflammatory, antibacterial, anti-ageing, composition is natural simply simultaneously, water-resistance is excellent, ability of fixing is strong, is a safe and practical, lasting stability, the novel transparent matter acid BB frosts of multi-efficiency.
Description
Technical field
The present invention relates to beauty filed of daily-use chemical industry, it is more particularly to a kind of with multi-efficiency hyaluronic acid BB frost and
Preparation method.
Background technology
BB frosts, it is BlemishBalm abbreviation, is the Novel foundation in order to protect, stabilizing and modify skin and research and develop, mesh
Preceding cooperation air cushion using effect is more preferably.Its effect mainly hides the flaw, the adjustment colour of skin, sun-proof, careful pore, realize foundation cream, every
From, hide the flaw, sun-proof and other effects, the sensation of NudeLook (nude look effect) can be created, turn into modern female make up it is indispensable
A part.
Also produced with human sciences's accumulation of knowledge, requirement of the people for cosmetics such as BB frosts with the improvement of living standards
Very big change has been given birth to, the effects such as the screening flaw of skin, the adjustment colour of skin, sun-proof and careful pore has no longer been contented just to, also requires
Product can attach more efficacy effects simultaneously.It is the foundation emulsion of multiple-effect unification to recognize most BB frosts simultaneously, relatively lighter
Thin, effect of fixing is bad, it is easy to which de- adornment, moisturizing degree, Bearberry Extract are nor too preferable.Also some BB frost containing it is a variety of into
Point, quality is thick and heavy, excessively focuses on hiding the flaw, and grease collocation is unreasonable, pigment essence anti-corrosion abuse, and have ignored skin bears energy
Power, the symptom such as allergy, coarse occurs in skin after long-term use, and such BB frosts are not easy to remove ornaments and formal dress, and often remain in skin
On, over time, the various skin problems such as clogging of pores, small pox just occur.In addition, there is multi-efficiency on the market at present
BB frosts are also very few, there is more still both effectiveness to realize by addition medicine, there's no such thing as a totally safe medicine, this medicine addition
Although what agent can be of short duration reaches the effect of moisturizing whitening antiallergic anti-inflammatory is antibacterial anti-ageing, but still long-term use of can make to skin
Into damage.Therefore, a kind of safer practicality of exploitation, lasting stability, the BB frosts of multi-efficiency are particularly urgent.
The content of the invention
To solve the technical problem of existing BB frosts product, there is provided a kind of screening flaw, the adjustment colour of skin, the base of sun-proof, careful pore
This effect, also with the multi-efficiency such as moisturizing, skin lightening, antiallergic, anti-inflammatory, antibacterial, anti-ageing, and composition is natural simply, water-resistance
Product excellent, ability of fixing is strong.
What the first technical scheme provided by the invention was realized in：
It is a kind of with multi-efficiency hyaluronic acid BB frost, said composition include following weight than component：
Wherein, non-plant sucrose clear cream：Element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon are slided by aloe silk
Eight kinds of blood tree, witch hazel active plants mix system with sucrose solution and matched somebody with somebody；
Wherein, function compound：System is mixed in proportion by niacinamide, allantoin and polyglutamic acid to match somebody with somebody.
Further, the aloe silk of each composition slides element, motherwort, horse chestnut, lophatherum gracile, white willow in non-plant sucrose clear cream
Skin, purslane, dragon tree, witch hazel, sucrose are 1-2 in mass ratio:0.5-1:1-2:1-2:0.5-1:1-3:0.5-1:2-3:
1-2 forms non-plant sucrose mixture.
Further, function compound niacinamide, allantoin, polyglutamic acid are 5-15 in mass ratio:0.5-1:0.5-1
Composition.
Further, the preferred shea butter of matrix auxiliary material, vegetable fat, plant emulsifying agent, titanium dioxide, sodium chloride, color
Powder, lavender oil, dipotassium glycyrrhizinate, EDTA- disodiums, parahydroxyacet-ophenone, 1,2- hexylene glycols, one kind in deionized water or two
More than kind.
Further, the hyaluronic acid uses 200-600KD macromolecular hyaluronic acid.
Second of technical scheme provided by the invention be：The preparation method of hyaluronic acid BB frosts,
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in 50g's in 35-40 DEG C
In 1.0% sodium chloride solution, 1000-3000r/min stirring digestion 3-4h, pH5.0-5.6 is adjusted, adds deionized water to mix to 100g
Close uniformly, be prepared into hyaluronic acid solution of the concentration range in 4.5%-9.0%, save backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1-2:0.5-1:1-2:1-2:0.5-1:1-3:0.5-1:2-3:1-2 forms non-plant sucrose mixture, wherein each composition
Optimum weight ratio 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1, co-grinding adds 10 times of amount water, boiling into 1000 grams of coarse powder
2 hours, filtration treatment, filter residue added 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount water, boiling 1 hour,
Filtration treatment, filtrate merge, be concentrated under reduced pressure at 50 DEG C relative density be 1.0g/ml clear cream, in use, plus ethanol make to contain
Alcohol amount stands 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, niacinamide, allantoin, polyglutamic acid 5-15 in mass ratio:0.5-1:0.5-1 composition function compounds, most preferably
Weight is than 10:1:0.5 weighs niacinamide, allantoin and polyglutamic acid respectively, first with the 30-50 DEG C of dissolving of 10-20 times of deionized water
Polyglutamic acid, add allantoin and be well mixed, niacinamide is added after cooling, be well mixed transparent solution, as function compounds
Thing, it is standby；
D, above-mentioned hyaluronic acid solution and function compound are taken, 30-50 DEG C of temperature control is stirred under 1000-2000r/min
20nim is mixed, above-mentioned non-plant sucrose clear cream is stirring evenly and then adding into and is ultrasonically treated 20-50min under 60-80HZ so that solution mixes
Close uniform；
Above-mentioned solution is slowly added into the material body configured in advance with matrix auxiliary material by e, and being gently mixed makes it divide completely
Dissipate；
F, pH4.0-9.0 is adjusted, it is standby that hyaluronic acid BB frosts are made.
The present invention is formed by different quality percentage by hyaluronic acid, non-plant sucrose clear cream, function compound, and is added phase
Close matrix auxiliary material and make hyaluronic acid BB frosts.Four kinds of key components respective specific composition, effect and mutual synergetical principle
It is as follows：
1st, hyaluronic acid：Also known as Hyaluronic Acid, it is a kind of high molecular polymer, by unit D-Glucose aldehydic acid and N- acetyl
The advanced acid mucopolysaccharide of aminoglucose composition, it is the tender important foundation material of skin water, itself is also a kind of composition of human body,
It has special water retention, and deal is more up to 100 times of itself weight, is that moisture retention is most in the nature having now been found that
Good material, it can also improve skin-nourishing metabolism, make skin it is tender, it is smooth, go to wrinkle, increase it is elastic, prevent aging, protecting
It is good skin penetration enhancer again while wet, is used cooperatively with other nutritional ingredients, promotion nutrient absorption can be played
More preferable effect；
2nd, non-plant sucrose clear cream：Element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon's blood are slided by aloe silk
Eight kinds of tree, witch hazel active plants mix in sucrose solution, are condensed into clear cream according to a certain percentage, then extract gained, the work
Property non-plant sucrose clear cream combined formulation in other active ingredients can be with efficient moisture-retention water lock, regulation skin water and oil balance, calmness
Releive, anti-inflammatory is antibacterial, bright color, it is anti-oxidant, anti-ageing wait for a long time have the function that deep layer nurse one's health skin；
2.1 aloe silks slide element：The polysaccharide material moisture retention that aloe silk is slided in element is strong, and it can supplement the water lost in skin
Point, recover the function of collagen, prevent facial wrinkles, holding skin is soft and moist, smooth, high resilience；It contain histamine and
The compositions such as prostaglandin inhibitor, ferric lactate, B family vitamin and enzyme, skin inflammation allergy can be prevented, promote cell metabolism
And skin regeneration, mitigate pain and itch, it is effective in cure to pimples, whelk, allergy, redness；Aloe silk is slided contained in element
Suppress melanin product, whiteness of skin can be made, desalinate color spot.Moisturizing, anti-inflammatory are mainly played in hyaluronic acid BB frosts, is highlighted
The effect of the colour of skin.
2.2 motherwort：Leonurus extract has good facilitation to NMF generation, has moisturizing to skin
Effect；There is good inhibiting rate to B-16 cells, therefore available for preventing and treating freckle, cutaneous pigmentation；With inoxidizability, knot
The activation to glutathione reductase is closed, there is Antiageing effect.It is mainly moisturizing in hyaluronic acid BB frosts, anti-oxidant anti-
Aging, the effect of bright color.
2.3 horse chestnut：Horse chestnut extract contains abundant aescin, is the most important composition to reduce inflammation, and it is logical
Cross and fill up veinlet and capillary microscopic nicks and trickle visible gap, can effectively improve the integrality of blood vessel astillen, because
This aescin helps to repair capillary；Horse chestnut extract can also play in external prescription and stimulate circulation, promote
Enter that wound healing, antioedematous, anti-inflammatory are impervious to be gone out with vascular protection to act on (go livid ring around eye, go red blood silk, crease-resistant, maintenance).Saturating
It is mainly the effect of anti-inflammatory in bright matter acid BB frosts.
2.4 lophatherum gracile：Research shows that Herba Lophatheri extract has antibiotic property, to Staphylococcus aureus, hemolytic streptococcus, green
Purulence bacillus and Escherichia coli have certain inhibitory action；The zoopery of Herba Lophatheri extract shows, it have suppress allergy and
The function of itching, it can be used as the anti-allergic agent of cosmetics.Mainly antibacterial, antiallergic the effect in hyaluronic acid BB frosts.
2.5 salicis,cortex：Active ingredient salicylic acid in Salix Babylonica L.P.E can alleviate headache as natural aspirin
With the pain caused by inflammation, there are expelling wind and removing dampness, sterilization swelling and pain effect；Skin surface dead skin cells can be gently dispelled simultaneously, are added
Fast senile cell comes off, and increases epidermal cell vigor, improves skin immunity, shines skin brilliance.In hyaluronic acid BB frosts
In mainly anti-inflammatory, the effect of bright color.
2.6 purslane：Can be with nutrition greasy skin and promotion epithelium containing plant polyose and vitamin in purslane extract
The physiological function of cell tends to be normal, reduces the generation of dead skin and cuticula caused by drying；Amino acid, it can be put down with vasoconstriction
Sliding flesh, maincenter that contraction has concurrently and peripheral, the skin and suppressing of can releiving dry caused by skin itching；Flavones and soap
Glucoside can remove free radical and anti-oxidant, delay skin aging；Alkaloid and flavones can be with antibacterial and suppression Common Pathogenic skins
Fungi.Mainly releived in hyaluronic acid BB frosts the antibacterial effect of calmness, antioxidant and anti-aging, anti-inflammatory.
2.7 dragon tree：Dragon tree extract contains thaspine (Taspine) and former cyanine (PAC).Thaspine has non-
Chang Qiang inoxidizability, skin keratin barrier can also be strengthened, and repair the facial obscure, skin caused by aging and external injury
The uneven skin of color, significantly improves the colour of skin and skin pattern；OPC be at present it is internationally recognized removing human free radical most
Effective natural, it potent can resist inflammation and repair damage, while establish skin moisture barrier, improve red blood
Silk and sensitivity.The effect of mainly anti-oxidant, anti-aging, bright color in hyaluronic acid BB frosts.
2.8 witch hazel：Hamamelis extract, which includes a variety of tannin matter, can adjust sebum secretion Hydrolyzed Protein and Milk Protein,
With effect that is calm, pacifying, to being cracked, tanning severely, acne have improvement, releive, and restrain, the effect of antibacterial, because there is receipts
Hold back oil-control, the significant curative effect of sterilization.In hyaluronic acid BB frosts mainly regulation water and oil balance, releive it is calm, antibiotic and sterilizing
Effect.
Sucrose is the small molecule wetting agent that content is high in beet, sugarcane and fruit, has good moisture-keeping function, necessarily
The sucrose solution of concentration has osmosis, and active ingredient can be promoted to rapidly enter acne skin and play efficacy effect, simultaneously
The sucrose solution of high concentration can also suppress harmful microbe growth.It is mainly moisturizing in hyaluronic acid BB frosts, promotees ooze, be antibacterial
Effect.
3rd, function compound：Arranged in pairs or groups and used with method according to a certain percentage by niacinamide, allantoin and polyglutamic acid, with reference to
Hyaluronic acid not only has certain collaboration moisture retention, can also effective bright color, reduction sensitization rate, deep layer reparation and nourishing
Skin, there is certain efficacy effect to skin and mucosa and skin；
3.1 niacinamide are a kind of water-soluble stable small molecular weight materials, can quickly pass through cuticula, can improve skin
The barrier action of skin, transepidermal water loss rate is reduced, melanosome can also be suppressed and be transferred to keratinocyte from chromatophore,
Suppress melanocyte transport way, reduce face red spot, pigment deposition, avoid the generation of pockmark, acne print, dermal collagen can also be promoted
The content of polysaccharide is sticked in albumen and regulation corium, repairs pockmark, can be by reducing the secretion of grease, reducing pore makes skin line
Manage moist.It is mainly bright color, moisturizing in hyaluronic acid BB frosts, repairs the effect nourished.
3.2 allantoin：It is main to do skin conditioning agent, protective agent use, it is good NMF, allantoin can reduce cutin
The adhesion strength of confluent monolayer cells, keratin can be softened, accelerate epidermal cell renewal, additionally it is possible to help skin anti-inflammatory, releive and promote
Cell repair, stimulation can be mitigated, while have antioxidation.Sensitization rate, moisturizing are mainly reduced in hyaluronic acid BB frosts, is repaiied
Multiple effect.
3.3 polyglutamic acid：It is reported that polyglutamic acid (γ-PGA) is a kind of water-soluble, biodegradation, made without toxicity
The boiomacromolecule made from microbe fermentation method, it is a kind of sticking material, is found first in " natto ".γ-
PGA is a kind of special anion nature polymer, be using the glutamic acid of left and right optical activity as cell cube, alpha-amido and γ-
Be bonded formed homotype polyamide polypeptide through acid amides between carboxyl, γ-PGA molecular weight from 5 ten thousand to 2 megadaltons not
Deng.Special molecular structure, extremely strong moisture-retaining capacity is made it have, can effectively increase the moisture-retaining capacity of skin, promote skin
Health, its superpower moisture-retaining capacity are better than common moisturizing ingredient, for the biotechnology NMF of a new generation.In hyaluronic acid
It is mainly the effect of moisturizing in BB frosts.
4th, matrix auxiliary material：It is preferred that shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, sodium chloride, toner, smoking clothing
It is more than one or both of careless oil, dipotassium glycyrrhizinate, EDTA- disodiums, parahydroxyacet-ophenone, 1,2- hexylene glycols, deionized water,
For product figuration and other effects.
Above-mentioned several component cooperative effects are,
(1) hyaluronic acid has excellent moisture retention, and it can improve skin-nourishing metabolism, make skin tender, smooth, light
Change microgroove, increase elasticity, prevent aging, be good skin penetration enhancer again while moisturizing, with other nutritional ingredients
It is used cooperatively, the more preferably synergy for promoting nutrient absorption can be played.
(2) eight kinds of natural active plants are condensed into clear cream in sucrose solution, and active component therein is in sucrose molecule
Together with tight clusters in the presence of hyaluronic acid, infiltration, it can efficiently suppress or kill Candida albicans, golden yellow Portugal
The bacteriums such as grape coccus, Escherichia coli, Pseudomonas aeruginosa and fungi, so as to reduce as the skin and mucosa infection and inflammation caused by them
The generation of reaction；The active ingredient in non-plant sucrose clear cream can also be quick in the presence of sucrose molecule and hyaluronic acid simultaneously
Into skin, so as to promote skin and mucosa to secrete functional component, and then suppress the inflammatory stimulus effect of inflammation and anti-endotoxin,
Reach the effect of enhancing skin and mucosa immunity；Non-plant sucrose clear cream, which includes plurality of active ingredients, can adjust sebum secretion, suppression
Melanin processed produces, removes free radical, stimulation of releiving, can with reference to compositions such as hyaluronic acid, polyglutamic acid, niacinamide and allantoins
So that skin reaches more preferably state, releive etc. and reach in replenishing water and preserving moisture, bright color, antioxidant and anti-aging and calmness
To synergy；Certain density sucrose clear cream has osmosis, and active ingredient can be promoted to rapidly enter skin and play work(
Effect acts on, while the sucrose clear cream of high concentration can also suppress harmful microbe growth, prevent skin infection and secondary inflammation
Occur.
(3) each composition in function compound is after certain proportion and method complex treatment obtain, with reference to hyaluronic acid and
Non-plant sucrose clear cream, which uses, to be reduced face red spot, pigment deposition with the generation and transfer of significantly more efficient suppression melanin, be risen
To the effect of uniform bright color；Dermal collagen can also be promoted and adjust the content that polysaccharide is sticked in corium, from skin
Deep layer carries out maintenance conditioning, smooth out wrinkles anti-aging；Skin anti-inflammatory, antiallergy can also be helped simultaneously, is releived and is promoted thin
Born of the same parents repair, and can improve the anti-irritant ability of skin, maintain the optimal health status of skin.
In a word, hyaluronic acid adds non-plant sucrose clear cream, the composition of function compound highlights antiallergic in moisturizing using it and disappeared
The multi-efficiency of scorching antibacterial anti-ageing aspect, not only has common BB by adding hyaluronic acid BB frosts made of related matrix auxiliary material
Frost hides the flaw, the adjustment colour of skin, the basic effect of sun-proof, careful pore, also with moisturizing, skin lightening, antiallergic, anti-inflammatory, antibacterial, anti-ageing etc.
Multi-efficiency, while composition is natural simply, water-resistance is excellent, ability of fixing is strong, is a safe and practical, lasting stability, multiple
The novel transparent matter acid BB frosts of effect.
Brief description of the drawings
Fig. 1 is percutaneous absorbability experimental result picture.
Embodiment
To describe the technology contents of the present invention, construction feature, the objects and the effects in detail, below in conjunction with embodiment
And accompanying drawing is coordinated to be explained in detail.
1st, a kind of composition and preparation method of the hyaluronic acid BB frosts with multi-efficiency
A kind of 1.1 composition components of the hyaluronic acid BB frosts with multi-efficiency
Said composition include following weight than component：
Wherein, non-plant sucrose clear cream：Element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon are slided by aloe silk
Eight kinds of blood tree, witch hazel active plants mix system with sucrose solution and matched somebody with somebody；
Wherein, function compound：System is mixed in proportion by niacinamide, allantoin and polyglutamic acid to match somebody with somebody.
Further, the aloe silk of each composition slides element, motherwort, horse chestnut, lophatherum gracile, white willow in non-plant sucrose clear cream
Skin, purslane, dragon tree, witch hazel, sucrose are 1-2 in mass ratio:0.5-1:1-2:1-2:0.5-1:1-3:0.5-1:2-3:
1-2 forms non-plant sucrose mixture, wherein each composition optimum weight ratio 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1.
Further, function compound niacinamide, allantoin, polyglutamic acid are 5-15 in mass ratio:0.5-1:0.5-1
Composition, optimum weight percent 10:1:0.5.
The preferred shea butter of matrix auxiliary material, vegetable fat, plant emulsifying agent, titanium dioxide, sodium chloride, toner, lavender
It is more than one or both of oil, dipotassium glycyrrhizinate, EDTA- disodiums, parahydroxyacet-ophenone, 1,2- hexylene glycols, deionized water.
Wherein, hyaluronic acid uses 200-600KD macromolecular hyaluronic acid.
1.2 preparation methods and embodiment
1.2.1 embodiment one：
Hyaluronic acid BB frost formulas (part by weight)
Hyaluronic acid 1.0%, non-plant sucrose clear cream 2.5%, function compound 2.0%, shea butter 2.0%, vegetable oil
Fat 10.0%, plant emulsifying agent 4.0%, titanium dioxide 14.0%, sodium chloride 1.2%, toner 0.8%, lavender oil 0.3%,
Dipotassium glycyrrhizinate 0.1%, EDTA- disodiums 0.1%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycols 0.3%, surplus deionization
Water is mended to 100.
Preparation method (technical scheme)
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 35 DEG C
Sodium chloride solution in, 1000 stirring digestion 3h, adjust pH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
5.0% hyaluronic acid solution, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1 weighs totally 1000 grams of each composition, and co-grinding adds into 1000 grams of coarse powder
10 times of amount water, boiling 2 hours, filtration treatment, filter residue add 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount
Water, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C, is used
When, add ethanol alcohol content is stood 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, in mass ratio 10：1：The 0.5 function compound for weighing niacinamide, allantoin and polyglutamic acid composition respectively is total to
2.0 grams, with 10 times of deionized waters, 45 DEG C of dissolving polyglutamic acids, add allantoin and be well mixed, niacinamide is added after cooling, mix
Uniform transparent solution, as function compound, it is standby；
D, 20.0 grams of above-mentioned hyaluronic acid solutions are taken, temperature control adds 2.0 grams of function compound 1000r/ at 35 DEG C
20nim is stirred under min, 2.5 grams of above-mentioned non-plant sucrose clear creams is stirring evenly and then adding into and is ultrasonically treated 25min under 60HZ so that
Solution is well mixed；
E, above-mentioned solution is slowly added into advance with shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, chlorine
Change in the system after sodium, toner, dipotassium glycyrrhizinate, EDTA- disodiums and deionized water emulsifying cooling, add lavender
Oil, parahydroxyacet-ophenone and 1,2- hexylene glycol, stir；
F, pH6.5 is adjusted, it is standby.
1.2.2 embodiment two：
Hyaluronic acid BB frost formulas (part by weight)
Hyaluronic acid 2.0%, non-plant sucrose clear cream 1.0%, function compound 3.5%, shea butter 2.0%, vegetable oil
Fat 10.0%, plant emulsifying agent 4.0%, titanium dioxide 14.0%, sodium chloride 1.2%, toner 0.8%, lavender oil 0.3%,
Dipotassium glycyrrhizinate 0.1%, EDTA- disodiums 0.1%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycols 0.3%, surplus deionization
Water is mended to 100.
Preparation method (technical scheme)
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 38 DEG C
Sodium chloride solution in, 1500 stirring digestion 3.4h, adjust pH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
6.0% hyaluronic acid solution, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1 weighs totally 1000 grams of each composition, and co-grinding adds into 1000 grams of coarse powder
10 times of amount water, boiling 2 hours, filtration treatment, filter residue add 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount
Water, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C, is used
When, add ethanol alcohol content is stood 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, in mass ratio 10：1：The 0.5 function compound for weighing niacinamide, allantoin and polyglutamic acid composition respectively is total to
3.5 grams, with 10 times of deionized waters, 45 DEG C of dissolving polyglutamic acids, add allantoin and be well mixed, niacinamide is added after cooling, mix
Uniform transparent solution, as function compound, it is standby；
D, 33.0 grams of above-mentioned hyaluronic acid solutions are taken, temperature control adds 3.5 grams of function compound 1500r/ at 40 DEG C
20nim is stirred under min, 1.0 grams of above-mentioned non-plant sucrose clear creams is stirring evenly and then adding into and is ultrasonically treated 30min under 70HZ so that
Solution is well mixed；
E, above-mentioned solution is slowly added into advance with shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, chlorine
Change in the system after sodium, toner, dipotassium glycyrrhizinate, EDTA- disodiums and deionized water emulsifying cooling, add lavender
Oil, parahydroxyacet-ophenone and 1,2- hexylene glycol, stir；
F, pH6.5 is adjusted, it is standby.
1.2.3 embodiment three：
Hyaluronic acid BB frost formulas (part by weight)
Hyaluronic acid 0.1%, non-plant sucrose clear cream 5.0%, function compound 0.5%, shea butter 2.0%, vegetable oil
Fat 10.0%, plant emulsifying agent 4.0%, titanium dioxide 14.0%, sodium chloride 1.2%, toner 0.8%, lavender oil 0.3%,
Dipotassium glycyrrhizinate 0.1%, EDTA- disodiums 0.1%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycols 0.3%, surplus deionization
Water is mended to 100.
Preparation method (technical scheme)
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 38 DEG C
Sodium chloride solution in, 1500 stirring digestion 3.4h, adjust pH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
6.0% hyaluronic acid solution, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1 weighs totally 1000 grams of each composition, and co-grinding adds into 1000 grams of coarse powder
10 times of amount water, boiling 2 hours, filtration treatment, filter residue add 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount
Water, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C, is used
When, add ethanol alcohol content is stood 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, in mass ratio 10：1：The 0.5 function compound for weighing niacinamide, allantoin and polyglutamic acid composition respectively is total to
0.5 gram, with 10 times of deionized waters, 45 DEG C of dissolving polyglutamic acids, add allantoin and be well mixed, niacinamide is added after cooling, mix
Uniform transparent solution, as function compound, it is standby；
D, 1.65 grams of above-mentioned hyaluronic acid solutions are taken, temperature control adds 0.5 gram of function compound 1200r/ at 40 DEG C
20nim is stirred under min, 5.0 grams of above-mentioned non-plant sucrose clear creams is stirring evenly and then adding into and is ultrasonically treated 50min under 80HZ so that
Solution is well mixed；
E, above-mentioned solution is slowly added into advance with shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, chlorine
Change in the system after sodium, toner, dipotassium glycyrrhizinate, EDTA- disodiums and deionized water emulsifying cooling, add lavender
Oil, parahydroxyacet-ophenone and 1,2- hexylene glycol, stir；
F, pH6.5 is adjusted, it is standby.
1.2.4 example IV：
Hyaluronic acid BB frost formulas (part by weight)
Hyaluronic acid 1.0%, non-plant sucrose clear cream 3.0%, function compound 1.5%, shea butter 2.0%, vegetable oil
Fat 10.0%, plant emulsifying agent 4.0%, titanium dioxide 14.0%, sodium chloride 1.2%, toner 0.8%, lavender oil 0.3%,
Dipotassium glycyrrhizinate 0.1%, EDTA- disodiums 0.1%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycols 0.3%, surplus deionization
Water is mended to 100.
Preparation method (technical scheme)
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 40 DEG C
Sodium chloride solution in, 2000 stirring digestion 3.8h, adjust pH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
8.0% hyaluronic acid solution, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1 weighs totally 1000 grams of each composition, and co-grinding adds into 1000 grams of coarse powder
10 times of amount water, boiling 2 hours, filtration treatment, filter residue add 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount
Water, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C, is used
When, add ethanol alcohol content is stood 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, in mass ratio 10：1：The 0.5 function compound for weighing niacinamide, allantoin and polyglutamic acid composition respectively is total to
1.5 grams, with 10 times of deionized waters, 45 DEG C of dissolving polyglutamic acids, add allantoin and be well mixed, niacinamide is added after cooling, mix
Uniform transparent solution, as function compound, it is standby；
D, 12.5 grams of above-mentioned hyaluronic acid solutions are taken, temperature control adds 1.5 grams of function compound 1000r/ at 40 DEG C
20nim is stirred under min, 3.0 grams of above-mentioned non-plant sucrose clear creams is stirring evenly and then adding into and is ultrasonically treated 35min under 65HZ so that
Solution is well mixed；
E, above-mentioned solution is slowly added into advance with shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, chlorine
Change in the system after sodium, toner, dipotassium glycyrrhizinate, EDTA- disodiums and deionized water emulsifying cooling, add lavender
Oil, parahydroxyacet-ophenone and 1,2- hexylene glycol, stir；
F, pH6.5 is adjusted, it is standby.
1.2.5 embodiment five：
Hyaluronic acid BB frost formulas (part by weight)
Hyaluronic acid 1.5%, non-plant sucrose clear cream 4.0%, function compound 2.5%, shea butter 2.0%, vegetable oil
Fat 10.0%, plant emulsifying agent 4.0%, titanium dioxide 14.0%, sodium chloride 1.2%, toner 0.8%, lavender oil 0.3%,
Dipotassium glycyrrhizinate 0.1%, EDTA- disodiums 0.1%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycols 0.3%, surplus deionization
Water is mended to 100.
Preparation method (technical scheme)
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in the 1.0% of 50g in 35 DEG C
Sodium chloride solution in, 2500 stirring digestion 4.0h, adjust pH5.5, add deionized water to be well mixed to 100g, being prepared into concentration is
8.0% hyaluronic acid solution, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel in mass ratio
With sucrose 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1 weighs totally 1000 grams of each composition, and co-grinding adds into 1000 grams of coarse powder
10 times of amount water, boiling 2 hours, filtration treatment, filter residue add 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue add again 8 times amount
Water, boiling 1 hour, filtration treatment, filtrate merge, and the clear cream that relative density is 1.0g/ml is concentrated under reduced pressure at 50 DEG C, is used
When, add ethanol alcohol content is stood 24 hours, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby up to 60%；
C, in mass ratio 10：1：The 0.5 function compound for weighing niacinamide, allantoin and polyglutamic acid composition respectively is total to
2.5 grams, with 10 times of deionized waters, 45 DEG C of dissolving polyglutamic acids, add allantoin and be well mixed, niacinamide is added after cooling, mix
Uniform transparent solution, as function compound, it is standby；
D, 18.75 grams of above-mentioned hyaluronic acid solutions are taken, temperature control adds 2.5 grams of function compound 1500r/ at 40 DEG C
20nim is stirred under min, 4.0 grams of above-mentioned non-plant sucrose clear creams is stirring evenly and then adding into and is ultrasonically treated 40min under 75HZ so that
Solution is well mixed；
E, above-mentioned solution is slowly added into advance with shea butter, vegetable fat, plant emulsifying agent, titanium dioxide, chlorine
Change in the system after sodium, toner, dipotassium glycyrrhizinate, EDTA- disodiums and deionized water emulsifying cooling, add lavender
Oil, parahydroxyacet-ophenone and 1,2- hexylene glycol, stir；
F, pH6.5 is adjusted, it is standby.
1.3 Efficacy experiments
1.3.1 the moisture retention experiment of hyaluronic acid BB frosts
The women 20 in 18-50 year the without disease of skin that experimental selection can be influenceed by result of the test completely is entitled
Object is tested, to test the moistening effect of hyaluronic acid BB frosts (each sample formula is as shown in table 1).Specific method is as follows：
Each experimental subjects first with behind water cleaning experiment position, then adapts to external environment condition 30 minutes before sample.The environmental condition of experiment
It is：22-24 DEG C of indoor temperature, indoor humidity 45-50% are kept, and is tested in same place.In inboard arm with 2*
2cm2 smears each 10ul of sample, and dries 1 minute.Then respectively apply the ultra-pure water for spreading 20ul again at the position of smearing, use towel
Dry after moisture with 1 point for interval (0 minute, 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9
Minute, 10 minutes), moisturizing is measured to the skin surface moisture at each smearing position with Corneometer CM 825 and imitated
Fruit.Measurement result is as shown in table 2, and unit is Corneometer value (Cv).
The each sample hyaluronic acid BB frosts composition of table 1 composition situation is as follows：
Note："-" represents to be not added with.
The each sample hyaluronic acid BB frost moistening effect measurement results of table 2 are as follows：
Conclusion：(1) certain weight ratio is pressed from table 1,2, hyaluronic acid, non-plant sucrose clear cream and function compound three
The moistening effect of BB frosts can be dramatically increased in BB frosts by applying；
(2) combined from table 1,2, hyaluronic acid, non-plant sucrose clear cream and function compound three by certain weight ratio
Manufactured hyaluronic acid BB frosts are than BB frost moistening effects made of single hyaluronic acid, non-plant sucrose clear cream, function compound
More preferably, illustrate hyaluronic acid, non-plant sucrose clear cream, function compound three combination made of BB frosts have in terms of moistening effect
Obvious chemiluminescence；
(3) from table 1,2, hyaluronic acid of the mass fraction in the range of 0.01-3.0%, in the range of 1.0-5.0%
Non-plant sucrose clear cream, in the range of 0.5-3.5% function compound three combination made of hyaluronic acid BB frosts in moisturizing
Chemiluminescence is respectively provided with terms of effect；
(4) comparative sample understand, hyaluronic acid, non-plant sucrose clear cream, function compound three addition be 1.0%,
2.5%th, 2.0% when, the moisturizing chemiluminescence of hyaluronic acid BB frosts is most reasonable, inadequate less than this value moistening effect, high
Slow down in this value moistening effect amplification and the problems such as expecting body waste, cost increase occur.
1.3.2 the percutaneous absorbability experiment of hyaluronic acid BB frosts
The mouse skin cuticula handled well is fixed on Franz diffusion cells upwards according to Transdermal Absorption experiment, connect
30% ethanol-physiological saline is added in receives pond, is placed in the intelligent penetrating absorption instrument of water bath with thermostatic control, design temperature (37.0 ±
0.5) DEG C, rotating speed 200rmin- 1.1h is balanced, sample is added after draining the bubble in reception tank.On diffusion cell supply area
Even smearing sample each 1g as shown in table 3, every group parallel 3 times, respectively 0,0.1,0.3,0.5,1.0,2.0,4.0,6.0,8.0,
10.0th, 12.0 when draw reception liquid 1mL, and fill into the reception liquid of equality of temperature same volume.The reception liquid of absorption adds examination after filtering
Pipe, then it is accurate add 2mLCTAB test solutions, enough long-times are rocked in the timing from when adding, gently vibration, and during which trying one's best avoids
Reaction solution produces foam, stands to close to 10min, then pours into reaction solution in 1cm cuvettes, and measure wavelength exists during 10min
Absorbance (A during 400nm400), the Transdermal absorption of hyaluronic acid is obtained according to the standard curve of hyaluronic acid at that wavelength
Rate.
The each sample hyaluronic acid BB frosts composition of table 3 composition situation is as follows：
| Hyaluronic acid | Non-plant sucrose clear cream | Function compound | Matrix auxiliary material | |
| Sample 1 | 1.0% | 2.5% | 2.0% | To 100 |
| Sample 2 | 1.0% | - | 2.0% | To 100 |
| Sample 3 | 1.0% | 2.5% | - | To 100 |
| Control group | 1.0% | - | - | To 100 |
Note："-" represents to be not added with.
Conclusion：Using hyaluronic acid transdermal absorption factor as ordinate, the time (t) is abscissa, draws the transdermal suction of hyaluronic acid
Yield-time graph, is shown in Fig. 1, as a result shows the absorptivity of hyaluronic acid in 12h for one ＞ samples of sample, three ＞ samples two ＞ pairs
According to group, show hyaluronic acid, non-plant sucrose clear cream, hyaluronic acid BB frosts are remarkably improved made of function compound three combination
The transdermal absorption factor of hyaluronic acid；As a result show that absorption of the 0.5h inner skins to hyaluronic acid is most fast, hyaluronic acid BB frosts exist
The transdermal absorption factor of hyaluronic acid is influenceed in 0.5h most notable；Experiment is shown by the research to hyaluronic acid transdermal absorption factor
There is hyaluronic acid BB frosts certain rush imbibition to receive effect.
1.3.3 the antiallergic anti-inflammatory anti-attenuation experiment of hyaluronic acid BB frosts
Now using human experimentation method detection hyaluronic acid BB frosts human body bioactivity, i.e., it is calm releive, anti-inflammatory
The activity of conditioning is repaired, nourishes, it is uncomfortable with conditioning skin to prevent to study hyaluronic acid BB frosts.
All experimenters of this experiment are different degrees of skin discomfort person, and each sample hyaluronic acid BB frosts composition forms such as
Shown in table 4, experimental group 1 uses the sample of the combination of hyaluronic acid 1.0%+ non-plant sucrose clear cream 2.5%+ functions compound 2.0%
Smeared 1 time before sleeping every night；Before experimental group 2 is slept every night using the sample of the combination of hyaluronic acid 1.0%+ non-plant sucroses clear cream 2.5%
Smear 1 time；Experimental group 3 is smeared 1 time before being slept every night using the sample of the combination of hyaluronic acid 1.0%+ functions compound 2.0%；Sun
Property control using hyaluronic acid 1.0% sample sleep every night before smear 1 time；Negative control sleeps preceding smearing every night using common BB frosts
1 time；Symptom improves situation after comparing five groups of conditionings 7 days.
Each experimental group sample solution composition composition situation of table 4 is as follows:
| Hyaluronic acid | Non-plant sucrose clear cream | Function compound | Matrix auxiliary material | |
| Experimental group 1 | 1.0% | 2.5% | 2.0% | To 100 |
| Experimental group 2 | 1.0% | 2.5% | - | To 100 |
| Experimental group 3 | 1.0% | - | 2.0% | To 100 |
| Positive controls | 1.0% | - | - | To 100 |
| Negative control group | - | - | - | To 100 |
Note："-" represents to be not added with.
The symptom assessments such as dermal sensation discomfort, allergy, inflammation, microgroove, peculiar smell, spot：
It is effective：Symptom is significantly improved or disappeared, experimenter's satisfaction；Effectively：Symptom has improvement or mitigated, and experimenter still has not
It is suitable, it is desirable to continue to nurse one's health；It is invalid：Symptom mitigates without obvious, and experimenter is unsatisfied with.
Statistical method：Statistical procedures are carried out using SPSS12.0 statistics softwares, compared between metering and enumeration data group
Examined compared with being examined using t with x2, with p<0.05 is statistically significant difference.
As a result it is as follows：
As shown in table 5, the 8th day symptom improves situation：Experimental group 1 effective 10, total effective rate 100%；Experimental group 2 is effective
6, effective 1, invalid 3, total effective rate 70%, obvious effective rate P compared with experimental group 1<0.01；Experimental group 3 effective 6, has
Effect 2, it is invalid, 2, total effective rate 80%, obvious effective rate P compared with experimental group 1<0.01；Effective 2 of positive control, effective 4
Example, invalid 4, total effective rate 60%, obvious effective rate P compared with experimental group 1<0.01.
The 8th day each group experimenter symptom of table 5 improves situation and is compared as follows：
| Group | Sample number | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Experimental group 1 | 10 | 10 | 0 | 0 | 100 |
| Experimental group 2 | 10 | 6 | 1 | 3 | 70 |
| Experimental group 3 | 10 | 6 | 2 | 2 | 80 |
| Positive control | 10 | 2 | 4 | 4 | 60 |
| Negative control | 10 | 0 | 0 | 10 | 0 |
Conclusion：
(hyaluronic acid 1.0%+ non-plant sucrose clear cream 2.5%+ functions compound 2.0% combines manufactured BB to experimental group 1
Frost) it is substantially (more transparent than experimental group 2 (hyaluronic acid 1.0%+ non-plant sucroses clear cream 2.5% combines manufactured BB frosts), experimental group 3
Matter acid 1.0%+ functions compound 2.0% combine made of BB frosts), positive control (made of hyaluronic acid 1.0% BB frost) and
Negative control (common BB frosts) is effectively.The hyaluronic acid BB frost human experimentations of the present invention show (1) hyaluronic acid, non-plant sucrose
BB frosts are to prevention and conditioning skin discomfort significant effect made of clear cream and function compound three combination；(2) hyaluronic acid, plant
Thing sucrose clear cream and function compound three combination made of BB frosts in a short time calm releive, anti-inflammatory reparation, nourish conditioning skin
Skin problem has certain effect, and permanence operation can be more preferably；(3) hyaluronic acid, non-plant sucrose clear cream and function compound three
BB frosts made of combination have obvious chemiluminescence in terms of preventing with conditioning skin discomfort.
1.3.4 the optimum proportioning experiment of hyaluronic acid BB frosts effect combination
0.01%, 1.0%, 3.0% hyaluronic acid, the plant sugarcane of proportioning 1.0%, 2.5%, 5.0% will be matched respectively
Sugared clear cream, the function compound and matrix auxiliary material (mending to 100%) of proportioning 0.5%, 2.0%, 3.5% are configured to BB frosts, owned
Ingredient percent summation 100%.All experimenters of this experiment are different degrees of skin discomfort person, and 1-27 is with saturating for experiment
The BB frosts of bright matter acid, non-plant sucrose clear cream and different ratio made of function compound three combination are smeared 2 times sooner or later daily
The orthogonal experiment of row Three factors-levels, the situation after observation conditioning；Positive control 28-30 be respectively adopted proportioning 0.01%,
1.0%th, BB frosts are smeared 2 times sooner or later daily made of 3.0% hyaluronic acid, the situation after observation conditioning；31 be negative control
Smeared 2 times sooner or later daily using common BB frosts, the situation after observation conditioning；Every group of 5 patients, compare symptom after nursing one's health 7 days and change
Kind situation.
The orthogonal experiment factor meter of table 6：
The symptom assessment standards such as dermal sensation discomfort, allergy, inflammation, microgroove, peculiar smell, spot are same as above.
Statistical method：Statistical procedures are carried out using SPSS12.0 statistics softwares, compared between metering and enumeration data group
Examined compared with being examined using t with x2, with p<0.05 is statistically significant difference.
The 8th day each group experimenter symptom of table 7 improves situation and is compared as follows：
Conclusion：
Experiment is used through human body, the results showed that uses the hyaluronic acid of proportioning 0.01%, 1.0%, 3.0%, proportioning
1.0%th, 2.5%, 5.0% non-plant sucrose clear cream, proportioning 0.5%, 2.0%, 3.5% function compound be configured to it is transparent
Matter acid BB frosts it is calm releive, anti-inflammatory reparation, nourish conditioning skin problem in terms of have the effect of certain, but do not limit to this model
Enclose；When the hyaluronic acid that proportioning is 1.0%, the non-plant sucrose clear cream for 2.5% is matched, matches the function compound for 2.0%
When being configured to hyaluronic acid BB frosts, effect embodiment is most obvious, and the proportioning is optimum proportioning.
1.3.5 the biocidal property experiment of hyaluronic acid BB frosts
Take Clinical isolation Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans a little, connect respectively
Kind cultivates 18h in broth bouillon at 37 DEG C.(calf serum that 20% is added in Pseudomonas aeruginosa broth bouillon) takes
Each bacterial strain nutrient broth culture of 18h cultures, it is made into bacteria suspension and is used to test.Take sterilizing test tubes 11 respectively, the 1st
Nutrient broth fluid nutrient medium 9ml is added, 2-10 branch adds 5ml, the 11st addition 10ml, separately sampled product solution such as table 8
Shown 1ml adds the 1st test tube, takes 5ml to add the 2nd after well mixed, is diluted to the 10th successively, the 11st is not loaded
Product are as control.Often pipe adds escherichia coli suspension 0.1ml, and 24h is cultivated at a temperature of 37 DEG C, takes out observation bacterial growth feelings
Condition.Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans are the same as above-mentioned Germicidal efficacy growing state.As test tube becomes cloudy, i.e. table
Show bacterial growth, sample is without bacteriostasis；As test tube is limpid, expression bacterial growth is suppressed.Experimental result is as shown in table 9,
Hyaluronic acid BB frosts of the present invention are to Clinical isolation Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans
There is stronger bacteriostasis.
The bacteriostatic experiment each sample solution composition of table 8 forms：
Note："-" represents to be not added with.
The each sample solution of table 9 corresponds to last limpid test tube numbering in bacteriostatic test：
| Escherichia coli | Staphylococcus aureus | Pseudomonas aeruginosa | Candida albicans | |
| Sample 1 | 7 | 6 | 6 | 7 |
| Sample 2 | 5 | 4 | 4 | 5 |
| Sample 3 | 2 | 2 | 1 | 2 |
| Sample 4 | 4 | 3 | 3 | 3 |
| Sample 5 | 2 | 1 | 1 | 1 |
| Sample 6 | 3 | 2 | 1 | 2 |
| Sample 7 | - | - | - | - |
| Sample 8 | - | - | - | - |
Note："-" represents not limpid.
By above-mentioned limpid broth tubes and control group the transferred species broth agar plates after diluting according to a certain percentage, observation
24h, the Cmin of no bacterial growth is bacteriocidal concentration, is designated as C, unit mg/mL, as a result as shown in table 10, illustrates this
Invention hyaluronic acid BB frosts to be clinically separated common Bacteria skin infection strain Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa,
Candida albicans has stronger bactericidal action, can effectively suppress the activity of these Bacteria skin infections to prevent and conditioning skin
It is uncomfortable；Simultaneously by contrast as can be seen that transparent made of hyaluronic acid, non-plant sucrose clear cream and function compound three combination
Matter acid BB frosts also have chemiluminescence at antibacterial aspect.
The each sample solution sterilization conditions of table 10：
| C (Escherichia coli) | C (staphylococcus aureus) | C (Pseudomonas aeruginosa) | C (Candida albicans) | |
| Sample 1 | 0.12 | 0.15 | 0.17 | 0.11 |
| Sample 2 | 0.22 | 0.37 | 0.40 | 0.25 |
| Sample 3 | 0.76 | 0.50 | 0.80 | 0.66 |
| Sample 4 | 0.47 | 0.52 | 0.55 | 0.60 |
| Sample 5 | 0.78 | 0.82 | 0.88 | 0.91 |
| Sample 6 | 0.46 | 0.52 | 0.77 | 0.51 |
| Sample 7 | - | - | - | - |
| Sample 8 | - | - | - | - |
| Control group | - | - | - | - |
Note："-" indicates no bactericidal properties.
1.3.6 the whitening that highlights of hyaluronic acid BB frosts is tested
Experiment crowd：Totally 60 people, female volunteers of the age between 18-50 year, experiment crowd are divided into four groups, and one group is
The dark yellow crowd of blee, two groups are that face has sunburn caused by primary macule, ultraviolet injury, after three groups have dark sore for face
Pigmentation, four groups have the bounce-back spot produced after multiple whitening failure, pigmentation for face.Respectively the present invention is used in face
Hyaluronic acid BB frosts are (by hyaluronic acid 1.0%, non-plant sucrose clear cream 2.5%, function compound 2.0% and matrix auxiliaries
Into hyaluronic acid BB frosts), study subject is used continuously 8 weeks daily using once, original life is kept during experiment
Regularity, without using other any products.
(1) measure of skin complexion：Under the conditions of 25 ± 1 DEG C of environment temperature, humidity 50 ± 5%, German Courage is used
The skin color tester ColorimeterCL400 of+Khazaka (CK) company production using 1 day before hyaluronic acid BB frosts and
Continuous use determines target site skin complexion L values, commented by measuring product using the change of front and rear skin L values for 8 weeks weekly
Estimate influence of the product to skin degree of highlighting.
(2) measure of dermal melanin：Under the conditions of 25 ± 1 DEG C of environment temperature, humidity 50 ± 5%, Germany is used
The dermal melanin and ferroheme measuring instrument MX18 of Courage+Khazaka (CK) company production are before using hyaluronic acid BB frosts
1 day and continuous use 8 weeks weekly, determine skin in melanin value, target site dermal melanin measurement 5 times, take its average value,
White-skinned face function of the product to skin is assessed by measuring product using the change of front and rear dermal melanin numerical value.
(3) researcher and research object carry out whitening efficiency assessment：Evaluation index include skin moisturizing, skin splash,
Skin gloss and gloomy skin color.
Influence of the hyaluronic acid BB frosts of table 11 to skin degree of highlighting is as follows：
The measurement result of the dermal melanin of table 12 is as follows：
The hyaluronic acid BB frosts of table 13 are following (to the white-skinned face function of skin) to dermal melanin inhibiting rate measurement result：
As shown in Table 11, the hyaluronic acid BB made of hyaluronic acid, non-plant sucrose clear cream, function compound three combination
Frost has the effect of notable bright color to the crowd of all kinds of skin quality, and permanence operation is more preferably；From table 12,13, this hair
Bright hyaluronic acid BB frosts have higher melanin inhibiting rate, and whitening effect is notable after long-term use.
1.3.7 the scour resistance experiment of hyaluronic acid BB frosts
The women 10 in 18-50 year the without disease of skin that experimental selection can be influenceed by result of the test completely is entitled
Object is tested, to test the anti-impact brushing effects of hyaluronic acid BB frosts in each embodiment.The environmental condition of experiment is basically identical,
And tested in same place.Sample is smeared with 2*2cm2 in inboard arm, after drying 1 minute, VISIA images are respectively adopted
Before analyzer test use, wash by water 15 minutes after use and after use after smoothness change, comprehensive acquirement smoothness rate of change
Data.Test result such as table 13.
The scour resistance test data of hyaluronic acid BB frosts is as follows in 14 each embodiment of table：
From the test data of table 14, the hyaluronic acid BB frosts in each embodiment wash by water 15 minutes with using after use
Smoothness changing value when not washing by water afterwards is little, and the smoothness changing value of commercially available common BB frosts is very big, shows that the present invention is transparent
Matter acid BB frosts have good erosion resistibility.
1.3.8 the resistance to migration test data of hyaluronic acid BB frosts is as follows in each embodiment：
The women 10 in 18-50 year the without disease of skin that experimental selection can be influenceed by result of the test completely is entitled
Object is tested, to test the anti-migration effect of hyaluronic acid BB frosts in each embodiment.The environmental condition of experiment is basically identical,
And tested in same place.Sample is smeared with 2*2cm2 in inboard arm, after drying 1 minute, VISIA images are respectively adopted
Before analyzer test use, after use and using it is rear wiped three times with paper handkerchief after red area, obtain red area area and become
The integrated data of change.Test result such as table 15.
The resistance to migration test data of hyaluronic acid BB frosts in 15 each embodiment of table
From the test data of table 15, when not wiping after the hyaluronic acid BB frosts in each embodiment are wiped three times with paper handkerchief and
Area change value it is little, and the area change value of commercially available common BB frosts is very big, shows that hyaluronic acid BB frosts of the present invention have very
Good ability of fixing.
1.3.9 the acute oral toxicity experiment of hyaluronic acid BB frosts
According to test basis《Disinfection technology standard》(defend method prison hair in the 3.4 of (third edition) first fascicle experimental technique specification
[1999] No. 448).By animal (regular grade NIH mouse 20, male and female half and half, 18~22g of body weight) water supply fasting 12 hours,
Distilled water is solvent, and tested material (the hyaluronic acid BB frosts in embodiment one) sets dosage as 5500mg/kg, by 0.2ml/20g bodies
Gavage syringe needle is reused once to fill tested material to animal.Observed immediately after administration and record the poisoning manifestations of animal, death toll and
Death time, secondary, two weeks observation periods are observed daily.Toxicity grading is carried out according to acute toxicity grading criteria.Experimental result：See
Examine in the phase, test mice does not occur manifest symptom, no dead generation.
The tested material of table 16 is to NIH chmice acute Oral toxicity result of the tests
Conclusion：Hyaluronic acid BB frosts of the present invention are to the acute through LD50 ＞ 5000mg/kg, the true nontoxic level in border of NIH mouse.
Embodiments of the invention are the foregoing is only, not thereby limit the scope of patent protection of the present invention, every utilization
The equivalent structure or equivalent flow conversion that description of the invention and accompanying drawing content are made, or directly or indirectly it is used in other correlations
Technical field, be included within the scope of the present invention.
Claims (8)
1. it is a kind of with multi-efficiency hyaluronic acid BB frost, said composition include following weight than component：
Wherein, non-plant sucrose clear cream：By aloe silk slide element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree,
Eight kinds of active plants of witch hazel mix system with sucrose solution and matched somebody with somebody；
Wherein, function compound：System is mixed in proportion by niacinamide, allantoin and polyglutamic acid to match somebody with somebody.
2. hyaluronic acid BB frosts as claimed in claim 1, it is characterised in that the aloe silk of each composition is slided in non-plant sucrose clear cream
Element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel, sucrose are 1-2 in mass ratio:0.5-1:
1-2:1-2:0.5-1:1-3:0.5-1:2-3:1-2 forms non-plant sucrose clear cream.
3. hyaluronic acid BB frosts as claimed in claim 2, it is characterised in that the aloe silk in the non-plant sucrose clear cream is slided
Each composition optimum weight ratio 1.5 of element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel, sucrose:
0.5:1:1:0.5:1.5:0.5:2.5:1。
4. hyaluronic acid BB frosts as claimed in claim 1, it is characterised in that niacinamide, allantois in the function compound
Element, polyglutamic acid 5-15 in mass ratio:0.5-1:0.5-1 is formed.
5. hyaluronic acid BB frosts as claimed in claim 4, it is characterised in that niacinamide, allantois in the function compound
Element, polyglutamic acid optimum weight percent are 10:1:0.5.
6. hyaluronic acid BB as claimed in claim 1 frost, it is characterised in that the preferred shea butter of matrix auxiliary material, vegetable fat,
Plant emulsifying agent, titanium dioxide, sodium chloride, toner, lavender oil, dipotassium glycyrrhizinate, EDTA- disodiums, parahydroxyacet-ophenone, 1,
It is more than one or both of 2- hexylene glycols, deionized water.
7. hyaluronic acid BB frosts as claimed in claim 1, it is characterised in that the hyaluronic acid is big using 200-600KD's
Molecular weight hyaluronic acid.
8. prepare the preparation method of above-mentioned hyaluronic acid BB frosts, it is characterised in that preparation process includes：
A, purity 90.0%-99.9% 200-600KD macromolecular hyaluronic acid is taken to be dissolved in 35-40 DEG C the 1.0% of 50g
In sodium chloride solution, 1000-3000r/min stirring digestion 3-4h, pH5.0-5.6 is adjusted, adds deionized water to be well mixed to 100g,
Hyaluronic acid solution of the concentration range in 4.5%-9.0% is prepared into, is saved backup；
B, aloe silk slides element, motherwort, horse chestnut, lophatherum gracile, salicis,cortex, purslane, dragon tree, witch hazel and sugarcane in mass ratio
Sugared 1-2:0.5-1:1-2:1-2:0.5-1:1-3:0.5-1:2-3:1-2 forms non-plant sucrose mixture, wherein each composition is optimal
Weight is than 1.5:0.5:1:1:0.5:1.5:0.5:2.5:1, co-grinding adds 10 times to measure water, boiling 2 is small into 1000 grams of coarse powder
When, filtration treatment, filter residue adds 8 times of amount water, boiling 1 hour, filtration treatment；Filter residue adds the water of 8 times of amounts, boiling 1 hour, filtering again
Processing, filtrate merge, be concentrated under reduced pressure at 50 DEG C relative density be 1.0g/ml clear cream, in use, plus ethanol make alcohol content
Up to 60%, 24 hours are stood, filtering, decompression filtrate recycling ethanol is simultaneously concentrated into no alcohol taste, standby；
C, niacinamide, allantoin, polyglutamic acid 5-15 in mass ratio:0.5-1:0.5-1 composition function compounds, optimum weight
Than 10:1:0.5 weighs niacinamide, allantoin and polyglutamic acid respectively, first with 30-50 DEG C of poly- paddy of dissolving of 10-20 times of deionized water
Propylhomoserin, add allantoin and be well mixed, niacinamide is added after cooling, be well mixed transparent solution, as function compound, it is standby
With；
D, above-mentioned hyaluronic acid solution and function compound are taken, is stirred under 30-50 DEG C of 1000-2000r/min of temperature control
20nim, it is stirring evenly and then adding into above-mentioned non-plant sucrose clear cream and is ultrasonically treated 20-50min under 60-80HZ so that solution mixes
Uniformly；
E, above-mentioned solution is slowly added into the material body configured in advance with matrix auxiliary material, being gently mixed is completely dispersed it；
F, pH4.0-9.0 is adjusted, it is standby that hyaluronic acid BB frosts are made.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653157A (en) * | 2018-08-22 | 2018-10-16 | 广州市藻谷生物科技有限公司 | A kind of cosmetic additive agent and preparation method and application with white-skinned face function |
| CN114681358A (en) * | 2022-02-16 | 2022-07-01 | 合肥卡迪尔生物科技有限公司 | Tyrosinase activity inhibitor and skin care product with synergistic whitening effect |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127325A (en) * | 2014-08-14 | 2014-11-05 | 陈展辉 | Optically variable BB cream |
| CN104473847A (en) * | 2014-11-27 | 2015-04-01 | 浙江长生鸟珍珠生物科技有限公司 | Pearl skin-whitening BB cream and preparation method thereof |
| CN104546651A (en) * | 2014-12-31 | 2015-04-29 | 广州九美仟惠生物科技有限公司 | BB cushion cream with light-induction color adjustment, light weight and blemish covering effects |
| CN105342884A (en) * | 2015-11-05 | 2016-02-24 | 杭州堡资达生物科技有限公司 | BB cream having whitening, moisturizing and makeup-dizziness preventing functions |
-
2017
- 2017-09-30 CN CN201710917323.0A patent/CN107737062A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127325A (en) * | 2014-08-14 | 2014-11-05 | 陈展辉 | Optically variable BB cream |
| CN104473847A (en) * | 2014-11-27 | 2015-04-01 | 浙江长生鸟珍珠生物科技有限公司 | Pearl skin-whitening BB cream and preparation method thereof |
| CN104546651A (en) * | 2014-12-31 | 2015-04-29 | 广州九美仟惠生物科技有限公司 | BB cushion cream with light-induction color adjustment, light weight and blemish covering effects |
| CN105342884A (en) * | 2015-11-05 | 2016-02-24 | 杭州堡资达生物科技有限公司 | BB cream having whitening, moisturizing and makeup-dizziness preventing functions |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653157A (en) * | 2018-08-22 | 2018-10-16 | 广州市藻谷生物科技有限公司 | A kind of cosmetic additive agent and preparation method and application with white-skinned face function |
| CN114681358A (en) * | 2022-02-16 | 2022-07-01 | 合肥卡迪尔生物科技有限公司 | Tyrosinase activity inhibitor and skin care product with synergistic whitening effect |
| CN114681358B (en) * | 2022-02-16 | 2023-11-21 | 合肥卡迪尔生物科技有限公司 | Tyrosinase activity inhibitor and skin care product with synergistic whitening effect |
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