CN105748347A - Plant medicinal composition with air pollution resistance effect and application of plant medicinal composition - Google Patents

Plant medicinal composition with air pollution resistance effect and application of plant medicinal composition Download PDF

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CN105748347A
CN105748347A CN201610114471.4A CN201610114471A CN105748347A CN 105748347 A CN105748347 A CN 105748347A CN 201610114471 A CN201610114471 A CN 201610114471A CN 105748347 A CN105748347 A CN 105748347A
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parts
plant
plant amedica
air pollution
medicinal composition
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龚盛昭
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Guangdong Industry Technical College
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Guangdong Industry Technical College
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a plant medicinal composition with an air pollution resistance effect and application of the plant medicinal composition. The plant medicinal composition is prepared from the following components in parts by weight: 8-10 parts of moringa oleifera, 5-25 parts of grape seeds, 5-25 parts of pomegranate bark, 5-30 parts of divaricate saposhniovia roots and 5-30 parts of cactus. The invention further discloses a preparation method and application of the plant medicinal composition with the air pollution resistance effect in cosmetics. The plant medicinal composition is based on the traditional Chinese medicine theory of assistant and guide, and due to synergism of multiple plant medicines, the purpose of pollution resistance can be achieved by virtue of comprehensive effects of clearing heat and removing toxin, scavenging free radicals, preventing allergy, preventing ultraviolet rays, inhibiting bacteria, promoting skin union and the like. Due to a scientific formula, the plant medicinal composition disclosed by the invention has good effects of air pollution resistance and skin hurt prevention when being used in cosmetics.

Description

A kind of plant amedica compositions with anti-air pollution effect and application
Technical field
The present invention relates to a kind of plant amedica compositions, a kind of plant amedica compositions with anti-air pollution effect and application, belong to cosmetic field specifically.
Background technology
In recent years, skin sufferer number sharply increases, trace it to its cause a lot, its Air Contamination is an important ring therein, air pollution is easily caused following skin problem: one is cause skin allergy: the floating thing allergy of a large amount of disperses in air, causes skin pore blocking and allergic symptom, makes people feel pruritus, play erythema welt, even trigger urticaria and eczema.Two is cause skin aging: pollutants in air, the free radical of the extremely unstable of skin generation excess can be made such as haze etc., these free radicals are by damaging the DNA of cell membrane and human body own health, thus accelerating organism aging process, aging including skin, such as dull-looking skin, pigmentation, skin easily relaxes, microgroove or wrinkle, xerosis cutis occur, even results in skin canceration.Whether three cause that skin easily infects: haze causes that the particle in air is too much, and printing opacity degree can reduce, and the ultraviolet making arrival Near Ground is weakened.So swim in various viruses, antibacterial and fungus in near-earth air to become to be not easy to be killed by ultraviolet.Poor for body constitution, there is skin allergy, the people of skin injury, this quasi-microorganism reaches skin along with the dust granules of air, and adheres to skin surface, it is easy to cause the infection of skin, such as folliculitis, tinea versicolor, herpes simplex etc., has the people of erythra to increase the weight of.
So, the outside contamination injury to skin to be resisted, should set about from aspects such as toxin expelling, antiallergic, scavenging free radicals, isolation ultraviolet, antibacterial and cleanings.
Summary of the invention
It is an object of the invention in conjunction with Traditional Chinese medical theory basis, it is provided that a kind of natural safe plant amedica compositions with anti-air pollution effect.
The preparation method that the second object of the present invention is to provide the above-mentioned plant amedica compositions with anti-air pollution effect.
The third object of the present invention is to provide the application in cosmetics of the plant amedica compositions with anti-air pollution effect.
To achieve the object of the present invention, present invention employs following technical scheme: having the plant amedica compositions of anti-air pollution effect, it is made up of the component including following parts by weight: moringa seeds 8～40 parts, Semen Vitis viniferae 5～25 parts, Pericarpium Granati 5～25 parts, Radix Saposhnikoviae 5～30 parts, Radix et Caulis Opuntiae Dillenii 5～30 parts.
Preferably, the plant amedica compositions (I) described in anti-air pollution effect is made up of the component including following parts by weight: moringa seeds 30 parts, Semen Vitis viniferae 20 parts, Pericarpium Granati 15 parts, Radix Saposhnikoviae 20 parts, Radix et Caulis Opuntiae Dillenii 15 parts.
Preferably, the plant amedica compositions (II) described in anti-air pollution effect is made up of the component including following parts by weight: moringa seeds 35 parts, Semen Vitis viniferae 25 parts, Pericarpium Granati 10 parts, Radix Saposhnikoviae 15 parts, Radix et Caulis Opuntiae Dillenii 15 parts.
Preferably, the plant amedica compositions (III) described in anti-air pollution effect is made up of the component including following parts by weight: moringa seeds 35 parts, Semen Vitis viniferae 15 parts, Pericarpium Granati 20 parts, Radix Saposhnikoviae 10 parts, Radix et Caulis Opuntiae Dillenii 20 parts.
The described plant amedica compositions with anti-air pollution effect adopts following preparation method: plant amedica pulverized, sieve by 20～100 mesh sieve respectively, mixing, it is that 5:1～20:1 adds Extraction solvent by liquid material mass ratio, after soaking 1～5h, extract at 10～100MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, with membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collect eluent, membrance concentration is 1:0.1～1:5 to the mass ratio of extracting solution Yu plant amedica, add butanediol to dissolve, filter, prepare plant amedica compositions.Extraction solvent is water, ethanol or ethanol water.
Described pollution resistant plant drug composition application in preparing cosmetics, it is characterised in that containing above-mentioned pollution resistant plant drug composition in cosmetics, its addition is calculated as 0.1～20% with mass fraction, it is preferable that addition is calculated as 1～10% with mass fraction.
The invention has the beneficial effects as follows: Chinese medicine beautifying theory is thought, good skin not only needs the modification of outside, it is often more important that skin health from inside to outside.Although the reason forming skin problem is various, but strong skin itself can resist environmental stimuli to a certain extent, so, traditional Chinese medical science antipollution is the process of a comprehensively regulating, is the ability reaching opposing outside contamination by strengthening the immunity of skin.
The present invention carries out prescription so that traditional Chinese medical science monarch is theoretical for guidance, and with moringa seeds for monarch drug, toxin expelling and acceleration metabolism are had special effect by moringa seeds, can accelerate skin metabolism toxin expelling, and have extraordinary moisturizing, antiallergic, antipruritic and uvioresistant effect；Semen Vitis viniferae and Pericarpium Granati are ministerial drug jointly, Semen Vitis viniferae has very strong scavenging free radicals, defying age, enhancing immunity and good antiallergic effect, containing multiple alkaloid in Pericarpium Granati, there is broad-spectrum antibacterial action, Propiobacterium, dysentery bacterium, staphylococcus aureus, Hemolytic streptococcus, vibrio cholera, dysentery bacterium etc. are had very strong inhibitory action；Radix Saposhnikoviae is adjuvant drug, has that very strong inducing diaphoresis to dispel wind, victory be wet, relieving convulsion effect；Radix et Caulis Opuntiae Dillenii, for making medicine, has the effects such as promoting flow of QI and blood, heat-clearing and toxic substances removing, moisturizing, has the effect of coordinating the actions of various ingredients in a prescription.All medicines share above, by force this primordial QI reinforcing, nourish conditioning, with strong skin for antipollution originally；To clean toxin expelling, antiinflammatory sterilizes, and antiallergic of releiving is the mark of antipollution.The plant amedica compositions of the present invention has the comprehensive effects such as extraordinary heat-clearing and toxic substances removing, scavenging free radicals, antiallergic, uvioresistant, antibacterial, promotion skin healing, makes an addition in cosmetics, and anti-air pollution effect is notable.
Detailed description of the invention
Below by way of specific embodiment come the present invention is further illustrated, but these embodiments simply to illustrate that, be not limitation of the present invention.
Embodiment 1 one kinds has plant amedica compositions (I) and the preparation method of anti-air pollution effect
A kind of plant amedica compositions with anti-air pollution effect, is made up of the vegetable drug component of following weight: moringa seeds 30g, Semen Vitis viniferae 20g, Pericarpium Granati 15g, Radix Saposhnikoviae 20g, Radix et Caulis Opuntiae Dillenii 15g.
Preparation method is as follows: plant amedica pulverized, and sieves by 60 mesh sieve, mixing, it is that 10:1 adds Extraction solvent by liquid material mass ratio, after soaking 2h, extracts at 50MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, by membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collecting eluent, membrance concentration, to extracting solution 50g, adds 50g butanediol and dissolves, filter, prepare plant amedica compositions (I).
Embodiment 2 one kinds has plant amedica compositions (II) and the preparation method of anti-air pollution effect
A kind of plant amedica compositions with anti-air pollution effect, is made up of the vegetable drug component of following weight: moringa seeds 35g, Semen Vitis viniferae 25g, Pericarpium Granati 10g, Radix Saposhnikoviae 15g, Radix et Caulis Opuntiae Dillenii 15g.
Preparation method is as follows: plant amedica pulverized, and sieves by 40 mesh sieve respectively, mixing, it is that 8:1 adds Extraction solvent by liquid material mass ratio, after soaking 2.5h, extracts at 60MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, by membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collecting eluent, membrance concentration, to extracting solution 50g, adds 50g butanediol and dissolves, filter, prepare plant amedica compositions (II).
Embodiment 3 has plant amedica compositions (III) and the preparation method of anti-air pollution effect
A kind of plant amedica compositions with anti-air pollution effect, is made up of the vegetable drug component of following weight: moringa seeds 35g, Semen Vitis viniferae 15g, Pericarpium Granati 20g, Radix Saposhnikoviae 10g, Radix et Caulis Opuntiae Dillenii 20g.
Preparation method is as follows: plant amedica pulverized, and sieves by 60 mesh sieve respectively, mixing, it is that 12:1 adds Extraction solvent by liquid material mass ratio, after soaking 2h, extracts at 50MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, by membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collecting eluent, membrance concentration, to extracting solution 50g, adds 50g butanediol and dissolves, filter, prepare plant amedica compositions (III).
The preparation of comparative example 1-5 monotaste plant medicament extract
Weigh plant drug material moringa seeds 100g respectively, Semen Vitis viniferae 100g, Pericarpium Granati 100g, Radix Saposhnikoviae 100g and Radix et Caulis Opuntiae Dillenii 100g, just plant amedica is pulverized, sieve by 60 mesh sieve, mixing, it is that 10:1 adds Extraction solvent by liquid material mass ratio, after soaking 2h, extract at 50MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, with membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collect eluent, membrance concentration is to extracting solution 50g, add 50g butanediol to dissolve, filter, prepare monotaste plant medicament extract.
The preparation of embodiment 4 antipollution facial cleaning cream
Table 1 provides the antipollution facial cleaning cream formula of the plant amedica compositions extract containing the present invention.
Table 1
Title Mass fraction (%)
Water To 100
Glycerol 4.00
EDTA disodium 0.05
Cocos nucifera oil acyl isethionic acid ester sodium 20.00
Methyl cocoyl sulphonic acid sodium 8.00
Lauric acid/dodecanoic acid 2.00
Tetradecylic acid 4.00
Cetearyl alcohol 3.80
Glyceryl stearate 0.75
PEG-100 stearate 0.25
Cocoyl glycine betaine 6.00
Olive oil PEG-7 esters 1.00
Hydroxypropyl methyl cellulose 0.15
DMDM hydantoin 0.30
A kind of plant amedica compositions extract (I) with anti-air pollution effect 5.00
Preparation method is as follows:
(1) after cocos nucifera oil acyl isethionic acid ester sodium and methyl cocoyl sulphonic acid sodium being heated in advance, put into oil cauldron together with other oiliness raw materials, be warming up to 75～80 DEG C of degree stirring and dissolving to fully transparent, for oil phase.
(2) aqueous materials is put into emulsifying pot, be warming up to 75～80 DEG C of degree stirring and dissolving uniform, for aqueous phase.
(3) by quick for oil phase suction emulsifying pot, continuously stirred with the speed of 30～50rpm, saponification 1.5 hours, emulsion process is maintained at 75～80 DEG C.
(4) saponification puts into cocoyl glycine betaine and olive oil PEG-7 esters after terminating, and stirring and dissolving uniformly starts cooling,
(5) being dissipated by hydroxypropyl methyl cellulose moisture, treat that temperature is down to 60 DEG C, put into emulsifying pot, stirring and dissolving is uniform.
(6) treating that temperature is cooled to 45 DEG C, put into surplus materials, stirring is to being uniformly dissolved.
(7) treat that temperature is down to 35 DEG C, vacuum defoamation, check color, fragrance, the physical and chemical index such as outward appearance, 200 orders filter discharging after the assay was approved.
The preparation of embodiment 5 antipollution protective skin cream
Table 2 provides the antipollution prescription for skin cream of the plant amedica compositions extract containing the present invention.
Table 2
Composition Mass fraction (%)
Arachidic alcohol glucoside 1.5
PEG-100 stearate 1.2
Glyceryl stearate 1.0
Cetearyl glucoside 0.8
Shea butter 0.5
White Limnanthes Alba Seed Oil 3.0
Parleam 3.0
Cyclomethicone 4.0
Polydimethylsiloxane 2.0
Methyl hydroxybenzoate 0.20
Propyl hydroxybenzoate 0.080
Deionized water Surplus
EDTA-2Na 0.02
Glycerol 5.0
1,3 butylene glycol 3.0
Hyaluronate sodium 0.05
Carbomer (CA) 0.2
Phenoxyethanol 0.30
Aminomethyl propanol 0.12
Essence 0.10
A kind of plant amedica compositions extract (I) with anti-air pollution effect 3.00
Its preparation method:
(1) being evenly stirred until transparent by 1,3 butylene glycol and hyaluronate sodium in advance, carbomer is made into the aqueous dispersions that mass fraction is 1%；
(2) Oil soluble materials being put into oil phase pot heat to 80 DEG C, stirring is to dissolving completely, for oil phase；
(3) putting into emulsifying pot through 1,3 butylene glycol, hyaluronate sodium and other Aqueous Phase Raw Material that step (1) is handled well to heat to 80 DEG C, stirring is to dissolving completely, for aqueous phase；
(4) by quick for oil phase suction agitated kettle, after addition, with the speed emulsifying 5～10 minutes of 4000～6000rpm, emulsifying is continuously stirred with the speed of 1000～2000rpm and start cooling after terminating；
(5) when being down to 65 DEG C, the aqueous dispersions that mass fraction is 1% for preparing through step (1) is added, with the speed homogenizing 2 minutes of 4000～6000rpm；
(6) treating that temperature is cooled to 45 DEG C, add other compositions, stirring is to being uniformly dissolved；
(7) treating that temperature is down to the physical and chemical indexs such as 35 DEG C of final vacuum deaerations, inspection color, fragrance, outward appearance, 200 orders filter discharging after the assay was approved.
The preparation of the common facial cleaning cream of comparative example 6
A kind of do not contain the present invention have anti-air pollution effect plant amedica compositions common facial cleaning cream, be made up of the component of following mass fraction:
Table 3
Title Mass fraction (%)
Water To 100
Glycerol 4.00
EDTA disodium 0.05
Cocos nucifera oil acyl isethionic acid ester sodium 20.00
Methyl cocoyl sulphonic acid sodium 8.00
Lauric acid/dodecanoic acid 2.00
Tetradecylic acid 4.00
Cetearyl alcohol 3.80
Glyceryl stearate 0.75
PEG-100 stearate 0.25
Cocoyl glycine betaine 6.00
Olive oil PEG-7 esters 1.00
Hydroxypropyl methyl cellulose 0.15
DMDM hydantoin 0.30
Preparation method is as follows:
Preparation method is as follows:
(1) after cocos nucifera oil acyl isethionic acid ester sodium and methyl cocoyl sulphonic acid sodium being heated in advance, put into oil cauldron together with other oiliness raw materials, be warming up to 75～80 DEG C of degree stirring and dissolving to fully transparent, for oil phase.
(2) aqueous materials is put into emulsifying pot, be warming up to 75～80 DEG C of degree stirring and dissolving uniform, for aqueous phase.
(3) by quick for oil phase suction emulsifying pot, continuously stirred with the speed of 30～50rpm, saponification 1.5 hours, emulsion process is maintained at 75～80 DEG C.
(4) saponification puts into cocoyl glycine betaine and olive oil PEG-7 esters after terminating, and stirring and dissolving uniformly starts cooling,
(5) being dissipated by hydroxypropyl methyl cellulose moisture, treat that temperature is down to 60 DEG C, put into emulsifying pot, stirring and dissolving is uniform.
(6) treating that temperature is cooled to 45 DEG C, put into surplus materials, stirring is to being uniformly dissolved.
(7) treat that temperature is down to 35 DEG C, vacuum defoamation, check color, fragrance, the physical and chemical index such as outward appearance, 200 orders filter discharging after the assay was approved.
The preparation of the common protective skin cream of comparative example 7
A kind of present invention that do not contain has the common protective skin cream of anti-air pollution effect plant amedica compositions, is made up of the component of following mass fraction:
Table 4
Composition Mass fraction (%)
Arachidic alcohol glucoside 1.5
PEG-100 stearate 1.2
Glyceryl stearate 1.0
Cetearyl glucoside 0.8
Shea butter 0.5
White Limnanthes Alba Seed Oil 3.0
Parleam 3.0
Cyclomethicone 4.0
Polydimethylsiloxane 2.0
Methyl hydroxybenzoate 0.20
Propyl hydroxybenzoate 0.080
Deionized water Surplus
EDTA-2Na 0.02
Glycerol 5.0
1,3 butylene glycol 3.0
Hyaluronate sodium 0.05
Carbomer (CA) 0.2
Phenoxyethanol 0.30
Aminomethyl propanol 0.12
Essence 0.10
Its preparation method:
(1) being evenly stirred until transparent by 1,3 butylene glycol and hyaluronate sodium in advance, carbomer is made into the aqueous dispersions that mass fraction is 1%；
(2) Oil soluble materials being put into oil phase pot heat to 80 DEG C, stirring is to dissolving completely, for oil phase；
(3) putting into emulsifying pot through 1,3 butylene glycol, hyaluronate sodium and other Aqueous Phase Raw Material that step (1) is handled well to heat to 80 DEG C, stirring is to dissolving completely, for aqueous phase；
(4) by quick for oil phase suction agitated kettle, after addition, with the speed emulsifying 5～10 minutes of 4000～6000rpm, emulsifying is continuously stirred with the speed of 1000～2000rpm and start cooling after terminating；
(5) when being down to 65 DEG C, the aqueous dispersions that mass fraction is 1% for preparing through step (1) is added, with the speed homogenizing 2 minutes of 4000～6000rpm；
(6) treating that temperature is cooled to 45 DEG C, add other compositions, stirring is to being uniformly dissolved；
(7) treating that temperature is down to the physical and chemical indexs such as 35 DEG C of final vacuum deaerations, inspection color, fragrance, outward appearance, 200 orders filter discharging after the assay was approved.
Test example 1 suppresses propionibacterium acnes efficacy assessments
1, the preparation of plant amedica extract sample
A kind of plant amedica extract with anti-air pollution effect plant amedica compositions extract and comparative example 1-5 embodiment 1 prepared all is formulated as the aqueous solution that mass fraction is 0.5%, 1.0%, 1.5% and 2.0%, standby.
, method of testing to propionibacterium acnes rejection ability
Respectively take 6 kinds of sample aqueous solution 1mL and be added separately in sterile glass test tube, topple over 8mL previously prepared improvement GAM broth bouillon respectively.Take out divided pure and at 35 DEG C of constant temperature CO2Incubator cultivates the clinical propionibacterium acnes of 48h, takes 1mL bacteria suspension respectively and injects in the human body culture medium test tube having added solution of extract, does negative control with a teat glass without bacteria suspension.Every kind of extract culture medium, all from low concentration, inoculates propionibacterium acnes successively, is placed in 35 DEG C of constant temperature CO after inoculation as early as possible2Incubator cultivates 48h.After cultivation, the liquid first extracted in human body culture medium carries out preliminary identification experiment, analyzes system again through VITEK full automatic microorganism, the situation of killing of propionibacterium acnes determined by ANI Identification of Anaerobic Bacteria card, and result is as shown in table 5 below:
Table 5
Test sample 0.5% 1.0% 1.5% 2.0%
Blank - - - -
Embodiment 1 - + + +
Comparative example 1 - - - +
Comparative example 2 - - - +
Comparative example 3 - - - -
Comparative example 4 - - + +
Comparative example 5 - - - +
Note :+positive, there is fungistatic effect ,-negative, without fungistatic effect
Result shows, propionibacterium acnes is had obvious inhibition by a kind of plant amedica compositions extract with anti-air pollution effect prepared by the present invention, synergism between compositions is notable, the monotaste plant medicament extract that propionibacterium acnes rejection ability is prepared apparently higher than comparative example.
Test example 2 scavenging free radicals effect assessment
1, the preparation of sample
Single medicinal material extract prepared by the Chinese medicine composition prepared by embodiment 1-3 and comparative example 1-5 is made into the sample solution that mass fraction degree of being is 1%, carries out experiment below.
2, ultra-oxygen anion free radical Scavenging activity is evaluated
Take the Tris-HCl buffer 4.5mL of 0.05mol/LpH=8.2, in 25 DEG C of water-baths, preheat 20min.Adding the pyrogallol solution of 1mL sample and 0.4mL25mmol/L, after mixing, react 5min in 25 DEG C of water-baths, the HCl1.0mL adding 8mol/L terminates reaction.Make reference with Tris-HCl buffer, survey absorbance at 299nm place.The solvent of blank 1mL sample substitutes sample.Clearance rate (D) is calculated according to formula (2).
Ultra-oxygen anion free radical clearance rate (%)=[1-(A2/A1)] × 100%(2)
In formula, A1 is the absorbance of blank；A2 is the absorbance of medicine.
3, the Scavenging activity evaluation to hydroxy radical
25mL color comparison tube is sequentially added into 2mmol/LFeSO43mL, 1mmol/LH2O23mL, shakes up, and is subsequently added into 6mmol/L salicylic acid 3mL, shakes up, and takes out, survey its absorbance after 37 DEG C of heating in water bath 15min；It is separately added into certain density liquid to be measured, shakes up, continue heating in water bath 15min, take out and survey its absorbance.Following formula is the liquid to be measured clearance rate to hydroxy radical (OH):
Scavenging action to hydroxyl free radical (%)=[A1-A2-(A1-A3)] A1 × 100%(3)
In formula, A1 does not add the absorbance of reaction system before medicine；A2 is the absorbance of system after medicine removing OH；A3 is the absorbance of system after blank removing OH.
4, experimental result
Anti-senescence function evaluation experimental is as shown in table 6.
Table 6
Sample To superoxide anion clearance rate, % To Scavenging action to hydroxyl free radical, %
Embodiment 1 91.1 89.6
Embodiment 2 92.4 88.3
Embodiment 3 90.6 90.2
Comparative example 1 85.3 81.6
Comparative example 2 88.2 85.3
Comparative example 3 80.6 81.4
Comparative example 4 53.2 31.6
Comparative example 5 56.7 42.8
Experiments show that the Chinese medicine composition potent scavenging free radicals of energy of the present invention has good anti-senescence function.And the scavenging free radicals of the single medicinal material extract more prepared than comparative example is effective, illustrates to serve the effect of Synergistic after optimum organization.
Test example 3 cleaning effect functional evaluation
1, test instrunment
The skin oil and fat content Sebumeter test probe that Courage+Khazaka company of Germany (CK company of Germany) manufactures.
2, facial area forehead oil stain removing rate method of testing
Choosing the volunteer 40 of oily skin, the age, men and women half and half at 20～35 years old.Volunteer can not use any control oil product in first 30 days of on-test, such as cosmetics or topical drug or health product for oral administration etc..Before test, enter temperature 22 ± 2 DEG C, sit quietly in the constant temperature and humidity room of humidity 50 ± 5% 30min, the left and right forehead of volunteer is chosen by random table, taking glabella center line with the cross point from upper eyebrow edge 1cm parallel lines is test midpoint, then put in testing and respectively test a position to from left to right side by side, take the meansigma methods oils and fats data as forehead 0h of 3 values, then require that experimenter uses sample clean 30min after cleaning by random table respectively at cheek one side, left and right, 2h, 4h, 6h, the each time point of 8h carries out oils and fats test, blank is for only cleaning with deionized water.
3, test result
Skin oil and fat content is shown in Table 7.
Table 7
Forehead oils and fats minimizing amount Embodiment 4 Comparative example 6 Blank
30min 43.5% 23.8% 7.1%
2h 31.8% 16.8% -3.6%
4h 25.4% 11.2% -6.8%
6h 19.5% 7.5% -5.1%
8h 13.7% 2.6% -15.2%
Result shows, joining in product by the plant amedica compositions of the present invention, can effectively remove skin excess oil regulation of skin fat secretion, its cleaning capacity is significantly larger than comparative example and blank example, so, the plant amedica compositions of the present invention has good cleaning action.
Test example 4 skin irritation evaluation experimental
Choosing 40 volunteers, men and women half and half.Antipollution protective skin cream that every volunteer's inboard arm uses embodiment 5 to prepare respectively and the common protective skin cream of comparative example 7 preparation.Check according to table 8 standard.Carry out experiment in 10 days altogether.Result is as shown in table 9.
Table 8
Grade Standard of perfection
0 Negative reaction: non-stimulated, without erythema
1 Suspicious reaction: slight erythema
2 Weak positive reaction: erythema
3 Strong positive reaction: erythema, pimple, vesicle
4 Extremely strong positive reaction: serious edema, bulla
Table 9
Allergy grade Comparative example 7 Embodiment 5
0 grade number 37 40
1 grade number 3 0
2 grade numbers 0 0
3 grade numbers 0 0
4 grade numbers 0 0
As seen from the results in Table 9, do not add the common protective skin cream allergic phenomena of comparative example 7 preparation of the Chinese medicine composition extract of the present invention, and allergic phenomena does not occur in the antipollution protective skin cream that with the addition of embodiment 5 preparation of the Chinese medicine composition extract of the present invention, illustrate that the Chinese medicine composition of the present invention has good antiallergic effect.

Claims (6)

1. a plant amedica compositions with anti-air pollution effect, it is characterised in that be made up of the plant amedica of following parts by weight: moringa seeds 25～30 parts, Semen Vitis viniferae 20～25 parts, Pericarpium Granati 15～20 parts, Radix Saposhnikoviae 15～20 parts, Radix et Caulis Opuntiae Dillenii 10～15 parts.
2. a plant amedica compositions with anti-air pollution effect, it is characterised in that be made up of the plant amedica of following parts by weight: moringa seeds 30 parts, Semen Vitis viniferae 20 parts, Pericarpium Granati 15 parts, Radix Saposhnikoviae 20 parts, Radix et Caulis Opuntiae Dillenii 15 parts.
3. a plant amedica compositions with anti-air pollution effect, it is characterised in that be made up of the plant amedica of following parts by weight: moringa seeds 35 parts, Semen Vitis viniferae 25 parts, Pericarpium Granati 10 parts, Radix Saposhnikoviae 15 parts, Radix et Caulis Opuntiae Dillenii 15 parts.
4. a plant amedica compositions with anti-air pollution effect, it is characterised in that be made up of the plant amedica of following parts by weight: moringa seeds 35 parts, Semen Vitis viniferae 15 parts, Pericarpium Granati 20 parts, Radix Saposhnikoviae 10 parts, Radix et Caulis Opuntiae Dillenii 20 parts.
5. the preparation method of a kind of plant amedica compositions with anti-air pollution effect described in any one of Claims 1 to 4, it is characterized in that preparing as follows: plant amedica pulverized, sieve by 20～100 mesh sieve respectively, mixing, it is that 5:1～20:1 adds Extraction solvent by liquid material mass ratio, after soaking 1～5h, extract at 10～100MPa and carry out extract at room temperature with high pressure homogenization method machine under pressure, after extracting solution is performing centrifugal separation on, with membrance concentration, concentrated solution macroporous resin adsorption, again with the ethanol that volume fraction is 10～95% repeatedly eluting, collect eluent, membrance concentration is 1:0.1～1:5 to the mass ratio of extracting solution Yu plant amedica, add butanediol to dissolve, filter, prepare plant amedica compositions；Extraction solvent is water, ethanol or ethanol water.
6. claim 1, claim 2, claim 3, pollution resistant plant's drug composition application in preparing cosmetics described in any one of claim 4, it is characterized in that its addition is calculated as 0.1～20% with mass fraction containing above-mentioned pollution resistant plant drug composition in cosmetics.
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106420467A (en) * 2016-10-23 2017-02-22 广东轻工职业技术学院 Anti-allergic plant moisturizing composition and application thereof
CN106731495A (en) * 2016-12-09 2017-05-31 重庆医学检验试剂研究所 A kind of composition and its application in air pollutants are removed
CN108904376A (en) * 2018-08-02 2018-11-30 广东轻工职业技术学院 It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application
CN108904306A (en) * 2018-09-03 2018-11-30 芜湖凌梦电子商务有限公司 Anti-fog haze Essence and preparation method thereof
CN109077957A (en) * 2018-08-02 2018-12-25 广东轻工职业技术学院 It is a kind of to have effects that the Chinese medicine composition fermentation liquid used for cosmetic of antipollution and its preparation and application
CN110368468A (en) * 2019-08-29 2019-10-25 无限极（中国）有限公司 A kind of composition and preparation method with antipollution damaging action, application
CN110507569A (en) * 2019-08-09 2019-11-29 湖北大学 Moringa seeds water extract, its extracting method and cosmetics

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
中华人民共和国卫生部: "《化妆品管理及安全性和功效性评价》", 31 January 2007, 化学工业出版社 *
刘军红 等: "生物碱提取、分离和纯化的研究进展", 《时珍国医国药》 *
安徽医学院: "《中毒急救手册》", 28 February 1978, 上海科学技术出版社 *

Cited By (9)

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Publication number Priority date Publication date Assignee Title
CN106420467A (en) * 2016-10-23 2017-02-22 广东轻工职业技术学院 Anti-allergic plant moisturizing composition and application thereof
CN106731495A (en) * 2016-12-09 2017-05-31 重庆医学检验试剂研究所 A kind of composition and its application in air pollutants are removed
CN108904376A (en) * 2018-08-02 2018-11-30 广东轻工职业技术学院 It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application
CN109077957A (en) * 2018-08-02 2018-12-25 广东轻工职业技术学院 It is a kind of to have effects that the Chinese medicine composition fermentation liquid used for cosmetic of antipollution and its preparation and application
CN108904376B (en) * 2018-08-02 2020-07-10 广东赛安特新材料有限公司 Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof
CN109077957B (en) * 2018-08-02 2021-02-09 广州优科生物科技有限公司 Traditional Chinese medicine composition fermentation liquor with anti-pollution effect for cosmetics and preparation and application thereof
CN108904306A (en) * 2018-09-03 2018-11-30 芜湖凌梦电子商务有限公司 Anti-fog haze Essence and preparation method thereof
CN110507569A (en) * 2019-08-09 2019-11-29 湖北大学 Moringa seeds water extract, its extracting method and cosmetics
CN110368468A (en) * 2019-08-29 2019-10-25 无限极（中国）有限公司 A kind of composition and preparation method with antipollution damaging action, application

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