CN105769698A - Cosmetic composition without preservative and application of cosmetic composition - Google Patents

Abstract

The invention relates to a cosmetic composition without a preservative. The cosmetic composition is prepared from, by mass, 0.5-5% of salicylic acid/dextrin/xanthan gum/amylopectin, 0.1-3% of aloe extract, 0.4-1% of p-hydroxyacetophenone, 0.5-10% of oat beta-glucan, 0.01-10% of herba centellae extract, 1-3% of 1,2-pentanediol and the balance auxiliary materials. The invention further provides application of the composition. The composition can perform the effects of resisting bacteria and diminishing inflammation, repairing wound scars, replenishing moisture and preserving moisture, and improving sebum secretion, and can be used for repairing various skin damages including acne. Besides, the composition does not contain a preservative, so that the irritation and influence on the skin by cosmetics are effectively relieved, and discomfort of the facial skin is not likely to be caused; the cosmetic composition is mild, free of irritation and suitable for crowds with various skin types.

Description

A kind of cosmetic composition without preservative and application thereof

Technical field

The present invention relates to cosmetic field, be specifically related to a kind of cosmetic composition without preservative and application thereof.

Background technology

Along with rapid development of economy, work, rhythm of life are increasingly faster, add adding further of city Air Contamination The impact of the many factors such as work and rest custom, the incorrect skin nursing that under play, and high pressure life, people are bad, more and more The synthtic price index that people is dried, the skin such as coarse, the colour of skin is obscure, corse sweat pore, small pox is disorderly puzzlement.Particularly by In factors such as environment, dietary habit change, stress increases, cause the sickness rate of small pox in the trend risen year by year.Small pox Also referred to as " acne ", " skin sore ", is that pilosebaceous a kind of chronic inflammatory skin is sick, feature be mainly in face acne, All kinds of skin injurys such as pimple, pustule, tuberosity.The generation of acne and hypersteatosis, pilosebaceous duct blocking, antibacterial Infect closely related with the factor such as inflammatory reaction.Its reparation course of disease is slow, the most repeatedly, has a strong impact on beauty treatment attractive in appearance, to people's heart Reason Health and Living quality affects greatly.Therefore, the reparation problem for skin is particularly important, particularly small pox skin The reparation problem of skin.At present, in existing cosmetics use chemosynthesis materials realize anti-acne, moisturizing, sterilize, reparation etc. Effect, although although these materials can complete above-mentioned functions, but its chemosynthesis material used and preservative etc. are to skin Skin has the strongest zest, the untoward reaction such as allergy easily occurs, and deteriorates the most impaired skin, it is also possible to makes to disappear Product is produced to use and relies on by the person of expense, and life-time service possibly even affects the hormone secretion of user, and then destroys user Healthy.Owing to anti-acne repairs the limitation of efficacy assessments method, the most generally there is anti-acne and repair in existing anti-acne reparation product Multiple limitation functionally.

Summary of the invention

It is an object of the invention to provide a kind of cosmetic composition without preservative and application thereof, said composition can Play anti-inflammation, repair wound cicatrix, replenishing water and preserving moisture, improve the effect of sebum secretion, can be used for repairing including small pox skin Various skin injurys.Therefore, it has improves cutaneous circulation, increases skin elasticity, accelerates wound healing, smooth skin Wound surface, reduces cicatrix and Pigmented effect.It addition, said composition is without preservative, effectively reduce cosmetics to skin The stimulation of skin and impact, do not easily cause the discomfort of face skin；Gentle, non-stimulated, it is suitable for all kinds of skin quality crowds and uses.

For solving the problems referred to above, the technical solution adopted in the present invention is as follows:

A kind of cosmetic composition without preservative, it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-5%, Aloe extract 0.1-3%, parahydroxyacet-ophenone 0.4- 1%, avenabeta glucosan 0.5-10%, Herba Centellae extract 0.01-10%, 1,2-pentanediol 1-3%, surplus is adjuvant.

Salicylic acid/dextrin/xanthan gum/amylopectin (INCI name: Salicylic Acid/Dextrin/Xanthan Gum/Amylopectin), salicylic acid is a kind of compound to acne with good therapeutic effect.It is the most fat-soluble Hydroxy acid, thus can penetrate pore depths, dredging pore, it is possible to effectively clear up dead skin cells, and impaired and dead in cleaning Die cell time healthy cell will not be impacted.It is slightly soluble in cold water, is soluble in hot water, ethanol, ether and acetone, at present Common measure includes into salt, adds surfactant, cyclodextrin inclusion compound or use ethanol water mixed solvent hydrotropy.U.S.'s dermatosis Association (AAD) evaluates salicylic acid: " it is a kind of effective skin cleaner, it can cross remove into pore helping unnecessary Fat, spot and the horn cell of death, alleviate scytitis, prevent the formation of comedo ".FDA (Food and Drug Adminstration) And the salicylic acid safe concentration permitted of dermatosis association of the U.S. (AAD) is 0.5-2%, in China's regulation skin protection cosmetics (FDA) Adding salicylic upper limit of concentration is 2%.

Aloe (Aloe, including Aloe vulgaris, Aloe arborescens var. natalensis, Aloe ferox Miller, Aloe Perryi Baker) extract: Aloe contains anthracene Quinone derivative, Aloe Radix Et Rhizoma Rhei, Saponin, aminoacid and polysaccharide etc..Having moisture-keeping function, anti-sunlight function, anti-aging effects, sterilization is made With, antiinflammatory action, immunity and regeneration, analgesia, sedation, antisepsis.Its main mechanism is the guarantor that (1) is natural Wet and lock water effect, promotes that fibrous polymer albumen is converted into NMF, thus increases nature moisturizing factor, immediately increase water content, logical Cross slight filming function and reduce percutaneous water loss (28 days reduce 20%)；Saccharide in Aloe and Amino acid profile are natural Moisture factor, can supplement the moisture lost in skin, recovers the function of collagen protein.Collagen protein has water storage function and changes The effect of water inlet metabolism；(2) one layer of smooth hygroscopic mem-brane can be formed at skin surface, because rich in polysaccharide, not increasing viscosity In the case of promote flexibility and the beautiful feeling of formula, and have the effect releived；(3) antiinflammatory and healing of wound effect, include life Thing enzyme, by slowly hydrolyzing with skin, plays the effect of bactericidal antiphlogistic, and under aminoacid effect, with collagen egg in horny layer White effect, healing of wound.Japanese scholars, through the research of 8 years, finds in Aloe possibly together with three kinds of chemical compositions, A Lao meter piperazine (Alomicin), Aloetin (Aloetin), Ah's Laue crow Rosin (Aloeulcin).And it is aobvious to think that cancer is had by A Lao meter piperazine Writing antagonism, Aloetin has the most antibacterial and mycostatic nature, can suppress the growth of pathogen bacteria, breeding and kill in a large number Going out them, Ah's Laue crow Rosin, to scalding, burn, abrade and ulcer playing Healing, has significantly treatment wound ability, can For the local of wound, it is substantially all and will not leave behind cicatrix.

Parahydroxyacet-ophenone: a kind of natural equivalent compound, (medical herbs originates in and draws to be present in Lampaya hieronymi Fourth America) and Rubus chamaemorus in (molka is grown on alpine zone).It has irritation in cosmetic formulations Activity also promotes the novel material of preservative efficacy, with other anticorrosion accelerator with the use of still having good preservative efficacy, makees For not interfering with again stability of emulsion while anticorrosion synergist.Additionally it also have antioxidation, irritation, emulsion stabilizer and The multi-efficiencies such as product protection agent.It can be dissolved in glycerol, water, glycol, ethanol and caprylic/capric triglyceride, additionization In cosmetic, operating procedure is simple.It has potential incompatibility with some specified proteins, therefore when containing albumen in formula During matter, need to measure formulation stability, it is to avoid variable color.

Avenabeta glucosan: a kind of natural non-starch class water-soluble plant sugar being present in big oat hull, it can be accelerated Determine the immunocyte of crowd, alleviate the reaction that antibacterial infects the position controlling antibacterial infection, make infection face recover as early as possible； There is the straight-chain molecular structure of uniqueness, impart good Transdermal absorption performance；Promote fibroblast synthesis collagen protein, promote Enter wound healing, repair impaired skin, give skin as silk, moisten smooth sense of touch.It addition, it is sun-proof except self having Effect (radical scavenging activity, antagonism uv damage) also can reduce outside pain inflammation, moreover it is possible to improves resisting skin allergy ability, Activate the multiple effects such as immunologic function, skin moisture-keeping, delay skin aging.Its powerful both originate from the activation to macrophage Effect.It is well known that macrophage is not only the non-single-minded cytotoxin of malignant cell, it can also attract immunity to live simultaneously Sexual cell and other leukocyte, thus promote wound healing and produce normal structure.Although macrophage membrane receptor is divided Separate out, but the activation mechanism of macrophage also imperfectly understands.Avenabeta glucosan can well by macrophage identification also Promote macrophage breeding, it may be possible to owing to its special snail stereochemical structure causes.

Herba Centellae extract: the dry herb of a kind of dicotyledonous samphire Herba Centellae, plants for perennial draft of crawling Thing, often crispaturas into bulk, and its stem is elongated, and tuberosity is taken root, and happiness is born in moistening riverbank, marsh, meadow, is mainly distributed in China Each province on the south the Changjiang river.In recent years, substantial amounts of research confirms that Herba Centellae extract has immunomodulating, antibacterial, the effect of antiinflammatory； Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, by epidermis and the corium connecting portion of compacting Decompose certainly cutis laxa phenomenon, make skin reach compact smooth effect and promote the several functions such as wound healing.Herba Centellae Extract main active in cosmetics is asiatic acid and Madecassic acid, asiaticoside and madacasso grass Glycosides.Its effect is as follows: (1) antibacterial action: asiatic acid and Madecassic acid belong to activity saponin material, can acidifying plant Cytoplasm in cell, thus protect plant self to resist the invasion and attack of yeast and mold.Herba Centellae extract is to green pus bar Bacterium, staphylococcus aureus, Propiobacterium etc. all have certain inhibitory action.(2) antiinflammation: Herba Centellae extract improve and Repair skin self barrier function, thus prevent and correct skin immunologic function disorder.(3) promote that fibroblast and collagen are thin The anabolic effect of born of the same parents: Herba Centellae extract can promote the synthesis of collagen protein I and III, also can promote the secretion of mucopolysaccharide simultaneously (such as the synthesis of hyaluronic acid), increases the water conservation degree of skin, activated fibroblast gene, strengthens the work of skin basal layer cell Power, keeps elasticity of skin and consolidation sense, smooth face fine wrinkles, makes skin be rich in reflecting feel.(4) colour of skin effect is improved: long-pending Snow grass extract has stronger antioxidation, can suppress free radical activity, desalinate melanin pigmentation, improves skin blood and follow Ring, promotion skin cell regeneration, help the smooth metabolism of melanin to go out external, make the smooth delicacy of skin, whitening beautiful.(5) cicatrix Repair: the pharmacological research that Chinese scholars is made shows, Herba Centellae extract has outstanding healing of wound and cicatrix is repaiied Multiple effect, its reason is that asiaticoside has the internal collage synthesis of promotion and the important work such as new vascular generation, stimulation granulation growth With, therefore beneficially wound healing.

Pentanediol (1,2-pentanediol): pentanediol is good wetting agent, the colourless liquid having slight characteristic odor, and There is the broad spectrum antibiotic activity of excellence.Cooperative effect is had between it and traditional preservatives, can be strong while reducing preservative consumption Change protective system performance and effectively reduce the zest of protective system.It is particularly suitable for tender and lovely skin such as infant and aging The nursing of dry skin.

Cosmetic composition of the present invention, with salicylic acid/dextrin/xanthan gum/amylopectin, Aloe extract, to hydroxyl Benzoylformaldoxime, avenabeta glucosan, Herba Centellae extract, 1, based on 2-pentanediol, by add adjuvant preparation possess anti-acne Repair the cosmetic composition of effect.

Adjuvant of the present invention include in water, alcohols, oil preparation, pH adjusting agent, surfactant one or both with On.Wherein, described alcohols is the one in 1,3-PD, 1,2-PD, glycerol or 1,3 butylene glycol or two More than Zhong.Described oil preparation is one or more in semi-synthetic oils and fats, higher alcohol, animal and plant fat or silicone oil. Described surfactant is selected from for emulsifying, the anion surfactant of hydrotropy, nonionic surfactant or both sexes One or more in surfactant.Described pH adjusting agent is in citric acid-sodium citrate, lactic acid-sodium lactate One.

In order to reach to promote anti-acne, moisturizing, sterilization, the purpose of repair, adjuvant of the present invention also includes compounding Other compositions, described other compounding compositions are selected from Herba portulacae extract, glycyrrhizic acid dipotassium, pantothenylol, hyaluronate sodium, allantois One or more in element, camomile extract, antipruritic and antipruritic agent.Wherein, described compounding composition accounts for described cosmetics group The 0.01%-10% of compound gross mass, preferably 0.1%-5%.

Cosmetic composition of the present invention is in water aqua type cosmetics, emulsion-type cosmetics, gel cosmetics or face Membranous type cosmetics are applied.

As preferably, described water aqua type cosmetics are that a kind of anti-acne repairs elite dew, and it includes based on weight/mass percentage composition Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-3%, Aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 0.8%, avenabeta glucosan 0.5-3%, Herba Centellae extract 0.3-10%, 1,2-pentanediol 1-2%；

Adjuvant: butanediol 3-7%, antipruritic and antipruritic agent 0.5-1%, 1,3-PD 5-12%, hydroxyethyl cellulose 0.1- 0.5%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, D-panthenol 0.5- 2%, hyaluronate sodium 0.01-0.1%, Herba Portulacae extract 0.5-3%, camomile extract 0.5-3%, sodium citrate 0.3- 0.35%, citric acid 0.004-0.008%, purified water supplies 100%.

As preferably, described patch type cosmetics are a kind of anti-acne repair surface pad pasting, and it includes based on weight/mass percentage composition Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-1%, Aloe extract 0.1-1%, parahydroxyacet-ophenone 0.4- 0.7%, avenabeta glucosan 0.5-2%, Herba Centellae extract 0.01-0.5%, 1,2-pentanediol 1-1.5%；

Adjuvant: butanediol 3-5%, antipruritic and antipruritic agent 0.5-1%, 1,3-PD 5-10%, xanthan gum 0.1-0.3%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, glycerol 1-4%, hyaluronic acid Sodium 0.01-0.1%, sodium citrate 0.23-0.35%, citric acid 0.003-0.005%, purified water supplies 100%.

As preferably, described emulsion-type cosmetics are that a kind of anti-acne repairs succinct breast, and it includes based on weight/mass percentage composition Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, Aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 1%, avenabeta glucosan 0.5-2%, Herba Centellae extract 0.3-3%, 1,2-pentanediol 1-2%；

Adjuvant: tristerin and PEG-100 tristerin 0.5-3%, polydimethyl siloxane fluid 1-3%, L-essence Propylhomoserin 0.8-1.5%, carbomer 0.8-1.5%, hexadecanol 0.1-2%, caprylic/capric triglyceride 3-6%, squalane 1- 2%, polysorbate60 1-4%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, D-panthenol 0.5-1%, hyaluronate sodium 0.01-0.1%, citric acid 0.004-0.01%, essence 0.02%, purified water is supplied 100%.

As preferably, described gel cosmetics are that a kind of anti-acne repairs curry, and it includes based on weight/mass percentage composition Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, Aloe extract 0.3-0.8%, parahydroxyacet-ophenone 0.5-1%, avenabeta glucosan 0.5-2%, Herba Centellae extract 0.3-0.8%, 1,2-pentanediol 1-2%；

Adjuvant: butanediol 3-10%, concentrated glycerin 3-5%, L-arginine 1-1.5%, carbomer 1-1.5%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.13%, allantoin 0.01-0.1%, D-panthenol 0.5-1%, hyaluronate sodium 0.01-0.05%, citric acid 0.003%, purified water supplies 100%.

Compared with prior art, it is an advantage of the current invention that:

The anti-acne repair of the salicylic acid of the present invention, Aloe, Herba Centellae extract and avenabeta glucosan is especially prominent. Aloe, containing abundant vitamin, aminoacid, fatty acid, polysaccharose substance, can penetrate into skin soon, through deep skin, Small pox skin had certain repair at interior various skin injurys；Aloe is possibly together with panimmunity protective factors and many Glucide is possible to prevent the delayed hypersensitivity of ultraviolet induction, inflammation-resisting itch-stopping, the pigmentation after reducing inflammation, favorably Recovery in impaired skin；Additionally the mucin of Aloe is in addition to promoting normal cell growth, also can make mass reduction, accelerates Repair of damaged tissues.By promoting granulation to be formed and the decomposition of various enzymes is to remove dead cell and infected group Knit.It does not only have extremely strong antiinflammatory and bactericidal action, also has and promotes cell metabolism and then promote the work of tissue regeneration With.Herba Centellae extract can promote the synthesis of collagen protein I and III, also can promote that the secretion of mucopolysaccharide is (such as hyaluronic acid simultaneously Synthesis), increase skin water conservation degree, activation update Skin Cell, make skin releive, promote and be rich in reflecting feel；Pass through CDNA arrangement testing research also finds, Herba Centellae extract also has the activation of fibroblast gene, can strengthen skin The vigor of basal layer cell, keeps elasticity of skin and consolidation sense, smooth face fine wrinkles.Avenabeta glucosan has uniqueness Straight-chain molecular structure, imparts good Transdermal absorption performance；Promote fibroblast synthesis collagen protein, promote that wound is more Close, repair impaired skin, give skin as silk, moisten smooth sense of touch.Salicylic acid is a kind of natural skin-protecting factor, energy Enough effectively clear up dead skin cells, dredging pore, dissolving acne, coarse skin also can be allowed to become smooth, pale.Para hydroxybenzene second Ketone has the multi-efficiencies such as antioxidation, irritation, emulsion stabilizer, anticorrosion accelerator and product protection agent.Pentanediol has excellence Broad spectrum antibiotic activity and performance of keeping humidity.The cosmetic composition being configured to for compositions with them, it is possible to obtain safety and Efficient anti-acne repairing effect.

1. the invention provides a kind of cosmetic composition without preservative, effectively reduce cosmetics to skin Stimulate and impact, do not easily cause the discomfort of face skin；Gentle, non-stimulated, it is suitable for all kinds of skin quality crowds and uses.

2. a kind of cosmetic composition without preservative that the present invention provides, containing natural moisturizing ingredient Herba bromi japonici β-Portugal Polysaccharide, simultaneously facilitates moisture absorption and the water metabolism of skin, and promotes the skin absorption to other effective ingredient；

3. a kind of cosmetic composition without preservative that the present invention provides, is not added with the preservative of synthetic, right Hydroxy acetophenone, 1,2-pentanediol, Herba Centellae extract and Aloe extract have synergetic antibacterial effect；It is applied to after formula also Need not add other preservative, can be effectively reduced its to the zest of sensitive skin and susceptibility, make skin to effectively The absorption of composition is more complete.

4. the present invention provide a kind of cosmetic composition without preservative, play anti-inflammation, repair wound cicatrix, Replenishing water and preserving moisture, improves the effect of sebum secretion, can be used for repairing small pox skin at interior various skin injurys.So having improvement Cutaneous circulation, increases skin elasticity, accelerates wound healing, smooth skin wound, reduces cicatrix and Pigmented effect.

Accompanying drawing explanation

The skin oil and fat content balance figure of Fig. 1: each time point of experimenter's forehead.

The skin oil and fat content balance figure of Fig. 2: each time point of the experimenter wing of nose.

The mean skin moisture comparison diagram of Fig. 3: each time point of experimenter's arm.

The photo of Fig. 4: experimenter former wound cicatrix.

Fig. 5: experimenter uses compositions photo of wound cicatrix after 2 months.

Fig. 6: experimenter uses compositions photo of wound cicatrix after 6 months.

Detailed description of the invention

Hereinafter embodiments of the invention are specifically described, in an embodiment of the present invention, cosmetics of the present invention The proportioning of compositions uses percentage by weight meter, can be content unit known to the field of medicaments such as μ g, mg, g, kg.The present invention In described cosmetic composition, each composition can be buied from chemical industry or medical market.Cosmetic composition system of the present invention Standby cosmetics or skin care item preparation do not limit form, such as, but not limited to, making water preparation, Emulsion, gel and facial film Deng form.

Embodiment 1-3

Cosmetic composition described in the present embodiment is fabricated to a kind of water aqua type cosmetics, is specially a kind of anti-acne and repairs essence Hua Lu, its formula is shown in Table 1.

The proportioning table of table 1 embodiment 1-3

Anti-acne described in the present embodiment repairs the preparation method of elite dew, sequentially includes the following steps:

1) sterilization of instruments: first with 80 DEG C of-100 DEG C of aquesterilisa, the instruments Appliances including reactor is cleaned, then use 75% ethanol for disinfection rinses, and cold wind dries up；

2) charging: add the purified water of formula ratio in reactor, begin to warm up, opens stirring, by propylene glycol, fourth two Add after alcohol, pentanediol and hydroxyethyl cellulose mixing and stir, more successively EDTA-2Na, parahydroxyacet-ophenone are added anti- Answering in still, be heated to 70-80 DEG C, stirring is allowed to fully dissolve, and is incubated half an hour, opens cooling, is down to when 45-50 DEG C add water Poplar acid/dextrin/xanthan gum/amylopectin, glycyrrhizic acid dipotassium, Aloe extract, Herba Centellae extract, allantoin and hyaluronic acid Sodium, stirring and dissolving is uniform.Continue to be down to 40-45 DEG C of addition avenabeta glucosan, D-panthenol, Herba Portulacae extract, Flos Matricariae chamomillae to carry Taking thing and antipruritic and antipruritic agent, stirring and dissolving is uniform；

3) pH is adjusted: add appropriate citric acid and sodium citrate stirring and adjusting pH to 5.5-6.5；

4) quality inspection subpackage: be down to after room temperature subpackage after passed examination.

Embodiment 4-6

Cosmetic composition described in the present embodiment is fabricated to a kind of face patch type cosmetics, is specially a kind of anti-acne repair surface Pad pasting, its formula is shown in Table 2.

The proportioning table of table 2 embodiment 4-6

The preparation method of the anti-acne repair surface pad pasting described in the present embodiment, sequentially includes the following steps:

1) sterilization of instruments: first with 80 DEG C of-100 DEG C of aquesterilisa, the instruments Appliances including reactor is cleaned, then use 75% ethanol for disinfection rinses, and cold wind dries up；

2) charging: in reactor, add the purified water of formula ratio, begin to warm up, open stirring, by glycerol, propylene glycol, Add after butanediol, pentanediol and xanthan gum mixing and stir, more successively EDTA-2Na, parahydroxyacet-ophenone are added reaction In still, being heated to 70-80 DEG C, stirring is allowed to fully dissolve, and is incubated half an hour, opens cooling, is down to when 45-50 DEG C add bigcatkin willow Acid/dextrin/xanthan gum/amylopectin, glycyrrhizic acid dipotassium, Aloe extract, Herba Centellae extract, allantoin and hyaluronic acid Sodium, stirring and dissolving is uniform.Continuing to be down to 40-45 DEG C and add avenabeta glucosan and antipruritic and antipruritic agent, stirring and dissolving is uniform；

3) pH is adjusted: add appropriate citric acid and sodium citrate stirring and adjusting pH to 5.5-6.5；

4) quality inspection subpackage: be down to after room temperature subpackage after passed examination.

Embodiment 7-9

Cosmetic composition described in the present embodiment is fabricated to a kind of emulsion-type cosmetics, is specially a kind of anti-acne and repairs essence Pure breast, its formula is shown in Table 3.

The proportioning table of table 3 embodiment 7-9

Anti-acne described in the present embodiment repairs the preparation method of succinct breast, sequentially includes the following steps:

1) prefabricated solution: by hyaluronate sodium, allantoin, Aloe extract, Herba Centellae extract and glycyrrhizic acid dipotassium, with suitable Amount purified water makes aqueous solution, standby；

2) aqueous phase: purified water, glycerol, butanediol, pentanediol and carbomer add a suitable vessel, and stirring mixing is all Even, add polysorbate60, EDTA-2Na and parahydroxyacet-ophenone, be heated with stirring to 75-80 DEG C, standby；

3) oil phase: by tristerin and PEG-100 tristerin, polydimethyl siloxane fluid, hexadecanol, octanoic acid/ Capric acid triglyceride and squalane add a suitable vessel, are uniformly mixed, and are heated to 75-80 DEG C, standby；

4) aqueous phase and oil phase are mixed, homogenizing 5-10 minute, then stop homogenizing, stirring cooling；

5) it is cooled to 60 DEG C, adds L-arginine, continue stirring cooling；

6) being cooled to 45 DEG C, addition salicylic acid/dextrin/xanthan gum/amylopectin, prefabricated solution, D-panthenol, Herba bromi japonici β-Portugal gather Sugar and essence, continue stirring cooling；

7) pH is adjusted: add appropriate citric acid stirring and adjusting pH to 6-7；

8) being cooled to 28 DEG C, allotment terminates.

Embodiment 10-12

Cosmetic composition described in the present embodiment is fabricated to a kind of gel cosmetics, is specially a kind of anti-acne reparation Curry, its formula is shown in Table 4.

The proportioning table of table 4 embodiment 10-12

Anti-acne described in the present embodiment repairs the preparation method of curry, sequentially includes the following steps:

1) prefabricated solution: by hyaluronate sodium, allantoin, Aloe extract, Herba Centellae extract and glycyrrhizic acid dipotassium, with suitable Amount purified water makes aqueous solution, standby；

2) aqueous phase: purified water, glycerol, butanediol, pentanediol and carbomer add a suitable vessel, and stirring mixing is all Even, add EDTA-2Na and parahydroxyacet-ophenone, be heated with stirring to 75-80 DEG C；

3) stirring cooling, is cooled to 60 DEG C, adds L-arginine, continues stirring cooling；

4) it is cooled to 45 DEG C, adds salicylic acid/dextrin/xanthan gum/amylopectin, prefabricated solution, D-panthenol and Herba bromi japonici β-Portugal Polysaccharide, continues stirring cooling；

5) pH is adjusted: add appropriate citric acid stirring and adjusting pH to 5.5-7；

6) being cooled to 28 DEG C, allotment terminates.

The product made to embodiment 1-12, with reference to the Microbial Challenge of American Pharmacopeia 2015 USP 38 editions test into Row test.Detection method and detection data see below:

Weighing the made product of above-described embodiment 1-12 respectively, the inoculation that carries out for the 0th day in test adds bacterium operation, exists respectively Add the bacteria containing amount in the 7th day after bacterium, the 14th day and the 28th day sampling analysis sample.

Result of the test is as shown in table 5:

The Microbial Challenge test of table 5 embodiment 1-12

The product of embodiment 1-12, the 7th day after inoculation, all clump counts are 0cfu/g, compared with initial value, carefully Bacterium test organisms number declines no less than 1.0lg, and the quantity that mycologic test bacterium increases is less than 0.5lg；The 14th day after inoculation, institute Having clump count to be 0cfu/g, compared with initial value, bacteria test bacterium number declines no less than 2.0lg, and mycologic test bacterium increases Quantity is less than 0.5lg；The 28th day after inoculation, all clump counts are 0cfu/g, and compared with 14 days, bacteria test bacterium increases The quantity added is less than 0.5lg, and compared with initial value, the quantity that mycologic test bacterium increases is less than 0.5lg；Test data table Bright, the product of embodiment 1-12 has good fungistatic effect.Microbial Challenge test carries out pass the test.

To anti-acne remediation composition (each component content: salicylic acid/dextrin/xanthan gum/amylopectin 2%, Aloe extract 3%, parahydroxyacet-ophenone 0.6%, avenabeta glucosan 10%, Herba Centellae extract 8%, 1,2-pentanediol 2%, purified water is mended Foot 100%.) carry out following experiment test:

1. suppression sebum secretion effect test:

Test sample: anti-acne remediation composition and water

Method of testing:

Randomly select skin health, without dermatosis and 30 experimenters of allergies, 30 experimenter's face areas are drawn Being divided into left and right face, left face is blank region, and right face is tested material the area of application, and left and right face can arbitrarily select the portion of face Position, takes point of symmetry as test point including at forehead, the wing of nose.Face is carried out with clear water, dries.By tested material with 1.25 μ L/cm2 coating density short-term is coated on tested region (right face) for 1 time, pats to absorption gently, uses skin oil measuring device (MPA 580 skinanalysis apparatus) measures the mean skin of each time point of each test point tested rear 0min, 30min, 1h, 2h respectively Fat content.

Test data, as shown in table 6 below, table 7, Fig. 1 and Fig. 2, are smeared sample at result display experimenter's forehead, the wing of nose and are resisted After pox remediation composition, mean skin fat content value is lower than water, illustrates that anti-acne remediation composition has significantly suppression sebum to divide The effect secreted.

Table 6: the skin oil and fat content of each time point of experimenter's forehead

Table 7: the skin oil and fat content of each time point of the experimenter wing of nose

2. moisture-keeping efficacy test

Test sample: anti-acne remediation composition and hyaluronic acid 0.1% aqueous solution.

Method of testing:

Randomly select skin health, without dermatosis and 30 experimenters of allergies, and choose the flexion of upper limb side of experimenter District's proper area is test section.By tested region by clean water before test, more naturally dry after the uniform wiping of ethanol 15min, with moisture of skin measurer (CM 825 skinanalysis apparatus) measure putting down before not smearing sample All moisture content of skin (blank value).The two kinds of samples coating 30 μ L in the range of experimenter's inner forearm 3cm × 3cm respectively are molten Liquid, with the complete uniform application of finger, pats to absorption gently.Measure after smearing 5 minutes with moisture of skin measurer, 30 points Zhong Hou, after 1 hour, the moisture content of skin after 2 hours, compares the mean skin water content of two each time points of sample.

Test data are as shown in table 8 below and Fig. 3, and result shows, smears the mean skin after sample anti-acne remediation composition Water content slightly above smears the mean skin water content value after hyaluronic acid 0.1% aqueous solution, and anti-acne remediation composition is described Replenishing water and preserving moisture effect is preferable.

Table 8: the mean skin moisture of each time point of experimenter's arm

3, cicatrix measure of merit is repaired:

Test sample: anti-acne remediation composition

Method of testing:

Every day coats the sample solution of 0.5-1mL sooner or later in the range of experimenter's established wound cicatrix respectively, uses The complete uniform application of finger, pats gently to absorption.Observing respectively after smearing sample 2 months, after 6 months, wound cicatrix repaiies Multiple effect.

Shown in observed result below figure 4, Fig. 5 and Fig. 6, result shows, smears sample anti-acne remediation composition after 6 months Wound cicatrix substantially improves, and illustrates that anti-acne remediation composition has the effect repairing wound cicatrix.

Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to limit the scope of protection of the invention with this, The change of any unsubstantiality that those skilled in the art is done on the basis of the present invention and replacement belong to institute of the present invention Claimed scope.

Claims (10)

1., without the cosmetic composition of preservative, it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-5%, Aloe extract 0.1-3%, parahydroxyacet-ophenone 0.4-1%, Avenabeta glucosan 0.5-10%, Herba Centellae extract 0.01-10%, 1,2-pentanediol 1-3%, surplus is adjuvant.

Cosmetic composition without preservative the most according to claim 1, it is characterised in that described adjuvant be water, One or more in alcohols, oil preparation, pH adjusting agent, surfactant.

Cosmetic composition without preservative the most according to claim 2, it is characterised in that described alcohols is for being selected from One or more in 1,3-PD, 1,2-PD, glycerol, 1,3 butylene glycol；Described oil preparation is for selected from half One or more in synthetic ester oil, higher alcohol, animal and plant fat, silicone oil；Described surfactant is for selected from being used for In emulsifying, the anion surfactant of hydrotropy, nonionic surfactant or amphoteric surfactant one or both with On；Described pH adjusting agent one in citric acid-sodium citrate, lactic acid-sodium lactate.

Cosmetic composition without preservative the most according to claim 2, it is characterised in that described adjuvant also includes multiple Other compositions joined, described other compounding compositions are selected from Herba portulacae extract, glycyrrhizic acid dipotassium, pantothenylol, hyaluronate sodium, urine One or more in Bursin, camomile extract, antipruritic and antipruritic agent；Wherein, described compounding composition accounts for described cosmetics The 0.01%-10% of compositions gross mass.

Cosmetic composition without preservative the most according to claim 4, it is characterised in that described compounding composition accounts for institute State the 0.1%-5% of cosmetic composition gross mass.

6., according to an application for the cosmetic composition described in claim 1-5 any one, it is used for preparing water aqua type by it Cosmetics, emulsion-type cosmetics, gel cosmetics or face patch type cosmetics.

The application of cosmetic composition the most according to claim 6, it is characterised in that described water aqua type cosmetics are a kind of Anti-acne repairs elite dew, and it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-3%, Aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 0.8%, avenabeta glucosan 0.5-3%, Herba Centellae extract 0.3-10%, 1,2-pentanediol 1-2%；

Adjuvant: butanediol 3-7%, antipruritic and antipruritic agent 0.5-1%, 1,3-PD 5-12%, hydroxyethyl cellulose 0.1- 0.5%, EDTA-2Na0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, D-panthenol 0.5- 2%, hyaluronate sodium 0.01-0.1%, Herba Portulacae extract 0.5-3%, camomile extract 0.5-3%, sodium citrate 0.3- 0.35%, citric acid 0.004-0.008%, purified water supplies 100%.

The application of cosmetic composition the most according to claim 6, it is characterised in that described patch type cosmetics are a kind of Anti-acne repair surface pad pasting, it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-1%, Aloe extract 0.1-1%, parahydroxyacet-ophenone 0.4- 0.7%, avenabeta glucosan 0.5-2%, Herba Centellae extract 0.01-0.5%, 1,2-pentanediol 1-1.5%；

Adjuvant: butanediol 3-5%, antipruritic and antipruritic agent 0.5-1%, 1,3-PD 5-10%, xanthan gum 0.1-0.3%, EDTA- 2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, glycerol 1-4%, hyaluronate sodium 0.01-0.1%, sodium citrate 0.23-0.35%, citric acid 0.003-0.005%, purified water supplies 100%.

The application of cosmetic composition the most according to claim 6, it is characterised in that described emulsion-type cosmetics are a kind of Anti-acne repairs succinct breast, and it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, Aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5-1%, Avenabeta glucosan 0.5-2%, Herba Centellae extract 0.3-3%, 1,2-pentanediol 1-2%；

Adjuvant: tristerin and PEG-100 tristerin 0.5-3%, polydimethyl siloxane fluid 1-3%, L-arginine 0.8-1.5%, carbomer 0.8-1.5%, hexadecanol 0.1-2%, caprylic/capric triglyceride 3-6%, squalane 1-2%, tells Temperature 60 1-4%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.15%, allantoin 0.01-0.3%, D-panthenol 0.5-1%, hyaluronate sodium 0.01-0.1%, citric acid 0.004-0.01%, essence 0.02%, purified water supplies 100%.

The application of cosmetic composition the most according to claim 6, it is characterised in that described gel cosmetics are one Kind of anti-acne repairs curry, and it includes the following component based on weight/mass percentage composition:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, Aloe extract 0.3-0.8%, parahydroxyacet-ophenone 0.5- 1%, avenabeta glucosan 0.5-2%, Herba Centellae extract 0.3-0.8%, 1,2-pentanediol 1-2%；

Adjuvant: butanediol 3-10%, concentrated glycerin 3-5%, L-arginine 1-1.5%, carbomer 1-1.5%, EDTA-2Na 0.05-0.1%, glycyrrhizic acid dipotassium 0.08-0.13%, allantoin 0.01-0.1%, D-panthenol 0.5-1%, hyaluronate sodium 0.01-0.05%, citric acid 0.003%, purified water supplies 100%.