CN106214532B - Composition and preparation method thereof with oil-control bacteriostasis efficacy - Google Patents
Composition and preparation method thereof with oil-control bacteriostasis efficacy Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
The present invention relates to a kind of compositions with oil-control bacteriostasis efficacy, it is formulated each component including following mass percent: PEG-20 methyl sesquistearate 0.8%~3.0%, isooctadecanol isostearate 1.0%~5.0%, methyl sesquistearate 1.0%~2.0%, isononyl isononanoate 2.0%~6.0%, glycerol 2.0%~8.0%, Sodium Hyaluronate 0.02%~0.1%, thickener 0.08%~0.3%, octyl butanedioic acid aluminium starch 0.5%~3.0%, propylene glycol 0.8%~5.0%, anti-sensitizer 0.1%~0.3%, Biopol β 2.0%~5.0%, glucan 1.0%~3.0%, hazel extract 1.0%~5.0%, surplus is deionization Water.The present invention provides, and there is the composition of oil-control bacteriostasis efficacy can persistently control skin oil and fat secretion, the extra grease that skin secretion can be absorbed simultaneously, has good antibacterial bacteriostatic effect, without adding preservative, it is a highly safe, without any side effects product.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of composition and its system with obvious oil-control bacteriostasis efficacy
Preparation Method.
Background technique
Sebum be by skin inside sebocyte cell generate, be secreted into the oil of skin surface.It is had shown that through research, sebum
Composition approximately as about 57% triglycerides or fatty acid, about 23% wax ester, about 12% squalene, about 3% steroid
Alcohol ester, 1~2% cholesterol.The metabolism in summer especially big in hot weather, humidity, human body itself can be accelerated, body
Interior sweat gland, sebaceous gland activity can be reinforced, and cause the secretion of sebum more and more, excessive sebum is distributed in skin surface, just
Pore can be blocked, causes cutin slightly thick, forms acne, the skin diseases such as seborrhea.
The secretion of the people of Oily, sebaceous glands are more vigorous, and facial perception is greasy, not easy to clean.Pore is coarse usually
Be hormone in vivo parasecretion, due to pressure is excessive and environmental pollution, cleaning are not carried out etc. caused by.With the age
Growth, environmental pollution, computer radiation, the appearance for the problems such as operating pressure is increasing, to cause many bad shadows to skin
It rings, the people of combination is more and more, and in addition to groups of people are born combination, some people is from neutral skin
Skin or Oily are transformed into combination.The formation of Combination or Oily is precisely due to skin oil and fat hypersecretion is made
At, fat secretion is excessive, and the grease support that pore can be stacked is big.In addition, with advancing age, skin gradually loses bullet
Property, perifollicolar lacks support construction, is also easy to that pore is made to seem bigger；Coarse pore is puzzlement oiliness and mixing skin
Greatest problem.
In the cosmetics of existing oil-control class, in order to control or regulate sebum secretion, one kind using some oil suction powders at
Point, these powder have hollow structure, the excess oil on skin can be largely adsorbed, such as: nylon powder, nitrogen
Change boron powder, talcum, silica, polymethyl methacrylate etc.；These ingredients are largely synthetic ingredient or mineralogical composition,
Other than absorbing extra sebum, it is difficult to have effects that further.Another major class is exactly to pass through chemical action, it can be reduced
The quantity of skin activity sebum body of gland, it is possible to reduce the fat secretion ability of skin activity sebaceous glands, to reach inhibition grease
Excessive secretion.The oil-control product of both types, due to acting on relatively simple, its oil-control less effective, and meanwhile it is not antibacterial
Effect, the even skin overdrying that can generate is used for a long time, or become not soft situation.
In addition, in order to reach ideal removing acnes and controlling oil effect, the anti-acne product of Cosmetic Market often will appear addition
Hormone, antibiotic and some other disabling limit the use of ingredient, these situations are very universal, and there are security risks for product use.
Summary of the invention
In order to solve the above-mentioned problems in the prior art, the present invention provides a kind of antibacterial with natural oil-control
The composition of effect, the composition can persistently control skin oil and fat secretion, while can absorb the extra grease of skin secretion,
There is good antibacterial bacteriostatic effect, without adding preservative.
Technical purpose of the invention is achieved through the following technical solutions:
Composition of the present invention with oil-control bacteriostasis efficacy, formula include each component of following mass percent:
PEG-20 methyl sesquistearate 0.8%~3.0%, isooctadecanol isostearate 1.0%~5.0%, methyl Portugal
Sugared sesquistearate 1.0%~2.0%, isononyl isononanoate 2.0%~6.0%, glycerol 2.0%~8.0%, hyaluronic acid
Sodium 0.02%~0.1%, thickener 0.08%~0.3%, octyl butanedioic acid aluminium starch 0.5%~3.0%, propylene glycol 0.8%
~5.0%, anti-sensitizer 0.1%~0.3%, Biopol β 2.0%~5.0%, glucan 1.0%~3.0%, witch hazel are extracted
Liquid 1.0%~5.0%, surplus are deionized water.
Preferably, the Particle size requirements of the octyl butanedioic acid aluminium starch are as follows: 95%~99% logical sieves with 100 mesh sieve.
Wherein, the Biopol β is bought to Qi company, Austria, the U.S., and the water-soluble products are sweet from the modification Portugal of konjaku root
The activity extract for revealing glycan and black willow bark is adjustable facial glossy and the microbial flora for causing acne is inhibited to generate.It is pungent
Base butanedioic acid aluminium starch (hereinafter referred to as DRY FLO PC) is bought to Akzo Nobel N.V., is through the hydrophobic of denaturation treatment
Property denaturation starch, be applicable to various personal care products, providing fine and smooth soft and smooth, velvet-like use feels, can be by
It is widely used in various talcum powders and spats powder, becomes " natural " sub of talcum powder.Witch hazel is the day of U.S. FDA identification
So, efficient astringent.The leaf and bark of witch hazel contain 8~10% tannic acid (mainly by hamameli tannin and galla turcica
The composition such as tannin), have and releives, restrains and haemostatic effect.
Further, the formula includes each component of following mass percent: PEG-20 methyl sesquialter stearic acid
Ester 0.8%~1.0%, isooctadecanol isostearate 2.0%~5.0%, methyl sesquistearate 1.0%~
2.0%, isononyl isononanoate 2.0%~3.0%, glycerol 5.0%~8.0%, Sodium Hyaluronate 0.02%~0.05%, thickening
Agent 0.08%~0.3%, octyl butanedioic acid aluminium starch 2.0%~3.0%, propylene glycol 3.0%~5.0%, anti-sensitizer 0.1%~
0.3%, Biopol β 2.0%~3.0%, glucan 2.0%~3.0%, hazel extract 1.0%~3.0%, surplus are
Deionized water.
Further, formula includes each component of following mass percent: PEG-20 methyl times semihard to the present invention
Resin acid ester 1.0%~3.0%, isooctadecanol isostearate 1.0%~5.0%, methyl sesquistearate 1.2%~
2.0%, isononyl isononanoate 2.0%~6.0%, glycerol 2.0%~5.0%, Sodium Hyaluronate 0.05%~0.10%, thickening
Agent 0.1%~0.3%, octyl butanedioic acid aluminium starch 0.5%~3.0%, propylene glycol 0.8%~5.0%, anti-sensitizer 0.2%~
0.3%, Biopol β 2.0%~5.0%, glucan 1.0%~3.0%, hazel extract 3.0%~5.0%, surplus are
Deionized water.
Specifically, the thickener be one or both of xanthan gum, carbomer, cellulose thickener, carragheen with
On combination.
Specifically, the anti-sensitizer is one of bisabolol, Ginger P.E, dipotassium glycyrrhizinate, allantoin or two
Kind or more combination.
Another technical purpose of the present invention is to provide a kind of method for preparing the above-mentioned composition with oil-control bacteriostasis efficacy, wraps
Include following steps:
1) is by the PEG-20 methyl sesquistearate, isooctadecanol isostearate, methyl of formula ratio times
Semi-solid fat acid esters, isononyl isononanoate sequentially add in emulsion pot, open stirring, are warming up to 70~80 DEG C, and heat preservation 10~
15min, as A group component；
Then plus deionized water 2) soaks the xanthan gum of formula ratio, Sodium Hyaluronate with glycerol, stirs and is warming up to
70~80 DEG C, 10~15min is kept the temperature to being completely dissolved, as B group component；The mixing speed of emulsion pot be maintained at 25~30 turns/
Min, by emulsion pot described in B phase vacuum suck, 8~10min of high speed homogenization is cooled to 40~45 DEG C；
3) octyl butanedioic acid aluminium starch is added in propylene glycol, stirs evenly, as C group component, emulsion pot is then added
In；
4) will successively add as the bisabolol of D group component, Phenoxyethanol, Biopol β, glucan, hazel extract
Enter in emulsion pot, stirring is uniform to being completely dispersed, discharging when being down to 35~40 DEG C.
Beneficial effects of the present invention:
Compared with commercially available oil control and acne removal product, present invention uses the high oil-control ingredient of natural, safety,
By scientific and reasonable collocation, apparent performance advantage is shown in terms of oil-control, antibacterial, anti-acne, skin, experiment shows
This product is highly safe, without any side effects.It is of the invention there is oil-control bacteria inhibiting composition to have compared with the prior art with
Under feature:
1, the composition of oil-control bacteriostasis efficacy of the invention can reduce the greasy feeling of the formulas such as lotion, cream, oily wax, can have
Effect absorbs the excess oil on skin, has obvious oil-control effect, while can reduce the growth of bacterium.
2, the composition of oil-control bacteriostasis efficacy of the invention uses the antibacterial component of natural origin oil-control, and mildness is obviously excellent
In salicylate, the update of epidermal cell can be promoted, inhibit to cause the skin flora that acne is formed, there is significantly antibacterial dispel
Acne effect.Its surface tension that can also reduce grease, promotes it to be dispersed into fine oil droplets, these small oil droplets are dispersed in skin
Skin surface can visually weaken the greasy feeling for even being eliminated skin.
3, since the composition of oil-control bacteriostasis efficacy of the invention is added to antibacterial action component, so can in product
Not add preservative, the safety of product is very high.
4, the composition of oil-control bacteriostasis efficacy of the invention contains there are many effect of repairing ingredient of releiving, and is conducive to acne print flesh
The reparation of skin.
Specific embodiment
The antibacterial essence Biopol β of natural oil-control of the invention, the water-soluble products derive from the modification Portugal sweet dew of konjaku root
The activity extract of glycan and black willow bark is adjustable microbial flora that is facial glossy and inhibiting to cause acne, is that solution is more
The newest breakthrough of Oily skin.Glucomannans is the heteroglycan of high molecular weight, is made of glucose and mannose.And konjaku root
Powder extracts are rich in glucomannans, are the splendid sources of carbohydrate.By a series of distinctive chemical reactions, by alkane
Base sulfonate chain is grafted on the branched group of polysaccharide molecule, improves the structure of this carbohydrate, formed it is not only hydrophilic but also
The molecule of oleophylic.
Biopol β contains black willow bark extracting solution, and black willow bark extracting solution contains natural beta-hydroxy acid active material,
But the irritation of salicylate, black willow bark extracting solution do not make as mild analgesic, preservative and antiphlogistic
With with very long history.Verified, it can promote the update of epidermal cell, inhibit to cause the skin bacteria that acne is formed
Group.It can reduce the surface tension of grease, it is promoted to be dispersed into fine oil droplets.These small oil droplets are dispersed in skin table
Face can visually weaken the greasy feeling for even being eliminated skin.When for cosmetics, it can control sebum on a skin surface
Flowing, mitigate greasy appearance, keep dermal sensation salubrious.And the natural salicylic acid activity contained by black willow bark extracting solution
Object then has the function of more neoblast and antibacterial, while almost without stimulation.
Octyl butanedioic acid aluminium starch is bought to Akzo Nobel N.V., and name of product is Dry Flo PC, freedom
Flowing, the thin particle size of children (Particle size requirements are as follows: 95%~99% passes through the sieves of 100 mesh), sufficiently small partial size make its tool
There is soft, velvet-like feeling, there is hydrophobicity and waterproofness.It can significantly reduce lotion, the greasy feeling of cream and ointment.
It absorbs extra grease and moisture content from face and body, provides a kind of very smooth skin sense.
In order to make the object, technical solutions and advantages of the present invention definitely, below to the preferred embodiment of the present invention into
The detailed description of row.In the embodiment of the present invention weight of each component can be kilogram or kilogram.
The present invention is further elaborated below by way of specific example, but the present invention is not limited thereto specific examples.
1、The formula of the composition of Examples 1 to 3 and reference examples 1
The formula of 1 composition of table
2. the preparation process of the composition of Examples 1 to 3
1) raw material of A group component is sequentially added in emulsion pot, opens stirring, is warming up to 70~80 DEG C, heat preservation 10~
15min。
2) deionized water is added in water phase pot, xanthan gum, the Sodium Hyaluronate in B group component is soaked with glycerol, so
It is added in water phase pot afterwards, opens stirring, be warming up to 80 DEG C, 10min is kept the temperature, until being completely dissolved.
3) mixing speed of emulsion pot is maintained at 30 turns/min, and B group component is passed through vacuum suck emulsion pot, high speed
(2500 revs/min~3000 revs/min) homogeneous 8min, starts to cool down, is down to 45 DEG C.
4) the Dry Flo PC of component C is added in propylene glycol, is stirred evenly, is added in emulsion pot.
5) D group component is successively sequentially added into emulsion pot, stirring goes out when being down to 35~40 DEG C up to being completely dispersed uniformly
Material, it is qualified to examine, and discharges filling.
The preparation method of reference examples 1 and the preparation method of Examples 1 to 3 are identical.
3. measure of merit
Composition with oil-control bacteriostasis efficacy of the invention passes through following three performance tests:
One, antibiotic effect is evaluated
Antibiotic effect test: it test basis and analysis method: is surveyed by EU criteria USP51, BP2002XVI C antibacterial efficacy
Examination measurement cosmetics resist the efficiency of microbial contamination, see table 2~5.
The test of 2 embodiment of table, 1 antibiotic effect
The test of 3 embodiment of table, 2 antibiotic effect
The test of 4 embodiment of table, 3 antibiotic effect
5 conclusion judgment criteria of table
Experimental result: the antibacterial system of Examples 1 to 3 has microorganism very strong by challenge test, the antibacterial system
Suppression kill effect, product production, storage and using when be not easy the pollution of microorganism.
Two, human skin patch
Composition with oil-control bacteriostasis efficacy of the invention contains natural black willow bark extracting solution and modified starch, formula
In be free of any chemical preservative, product is highly safe, and product has passed through human skin patch test, test side
Method and as follows as the result is shown:
Evaluation method:
1.1 tested materials: Examples 1 to 3, reference examples 1 (commercially available oil-control essence cream).
1.2 negative controls: blank control.
1.3 subjects: totally 25 people, male 12 people, 13 people of female the age 18~30 years old, meet subject and volunteer inclusion criteria.
Spot test method: selecting qualified spot tester, with enclosed patch test method, by tested material about 0.02ml~
0.025ml is applied in spot tester, and external application special adhesive tape is pasted on subject's forearm song side, removes tested material after 24 hours, in going
Except 30min after tested material spot tester, dermoreaction is observed after impression disappearance, by " cosmetics health specification " (version in 2007)
Dermoreaction grade scale records its result.
1.4 evaluation of result: reaction result is recorded by table 6 (skin adverse reaction grading standard).
6 skin adverse reaction grading standard of table
Test result is shown in Table 7:
7 cosmetic skin patch test results of table
The above results show that: in Examples 1 to 3,25 subjects skins are all negative (grading system: 0 grade).
According to " cosmetics health specification " (version in 2007) human skin class patch test judgment criteria, sample is bad anti-without skin to human body
It answers, embodiment all has good safety.Reference examples 1 have 21 order reactions, and the safety of product is not good enough.
Three, long-acting oil control effect experiment
The volunteer of 120 oiliness or combination is chosen, the age was 18~40 one full year of life, was divided into 4 groups, every group of 30 people.
Application method: being surrounding using the time, twice daily by the invention patent product (Examples 1 to 3) and reference examples 1
(commercially available oil-control essence cream) is applied to the forehead left and right sides of experimenter respectively, obtained makeup in each embodiment of comparative analysis
The oil-control effect of product.Wherein, the oil-control effect is that face is glossy, pore is coarse, the improvement situation of blackhead, as a result be see the table below
8:
Experimental result: the composition with oil-control bacteriostasis efficacy of Examples 1 to 3 does not find to stimulate during on probation
Property and allergic phenomena.Reference examples 1 have 2 volunteers the case where allergy occur.Experiment results proved, each product pair of Examples 1 to 3
Face is glossy, pore is coarse, the improvement degree of blackhead is apparently higher than control group 1.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.Here all embodiments can not be exhaustive.It is all to belong to this hair
The obvious changes or variations that bright technical solution is extended out are still in the scope of protection of the present invention.
Claims (4)
1. a kind of composition with oil-control bacteriostasis efficacy, which is characterized in that it is formulated each group including following mass percent
Point: PEG-20 methyl sesquistearate 0.8%~3.0%, isooctadecanol isostearate 1.0%~5.0%, methyl
Glucose sesquistearate 1.0%~2.0%, isononyl isononanoate 2.0%~6.0%, glycerol 2.0%~8.0%, hyalomitome
Sour sodium 0.02%~0.1%, thickener 0.08%~0.3%, octyl butanedioic acid aluminium starch 0.5%~3.0%, propylene glycol
0.8%~5.0%, anti-sensitizer 0.1%~0.3%, Biopol β 2.0%~5.0%, glucan 1.0%~3.0%, witch hazel
Extracting solution 1.0%~5.0%, surplus are deionized water；The thickener is xanthan gum；The anti-sensitizer is bisabolol；
The method of the composition with oil-control bacteriostasis efficacy the following steps are included:
1) is by PEG-20 methyl sesquistearate, isooctadecanol isostearate, the methyl times semihard of formula ratio
Resin acid ester, isononyl isononanoate sequentially add in emulsion pot, open stirring, are warming up to 70~80 DEG C, keep the temperature 10~15min, make
For A group component；
2) soaks the xanthan gum of formula ratio, Sodium Hyaluronate with glycerol, then plus deionized water, stir and it is warming up to 70~
80 DEG C, 10~15min is kept the temperature to being completely dissolved, as B group component；The mixing speed of emulsion pot is maintained at 25~30 turns/min,
By in emulsion pot described in B phase vacuum suck, 8~10min of high speed homogenization is cooled to 40~45 DEG C；
3) octyl butanedioic acid aluminium starch is added in propylene glycol, stirs evenly, and as C group component, is then added in emulsion pot；
4) will be sequentially added in emulsion pot as the bisabolol of D group component, Biopol β, glucan, hazel extract, be stirred
Mix, when being down to 35~40 DEG C discharging uniform to being completely dispersed.
2. the composition according to claim 1 with oil-control bacteriostasis efficacy, which is characterized in that the octyl butanedioic acid aluminium
The Particle size requirements of starch are as follows: 95%~99% passes through the sieve of 100 mesh.
3. the composition according to claim 1 or 2 with oil-control bacteriostasis efficacy, which is characterized in that it includes such as that it, which is formulated,
The each component of lower mass percent: PEG-20 methyl sesquistearate 0.8%~1.0%, isooctadecanol isostearic acid
Ester 2.0%~5.0%, methyl sesquistearate 1.0%~2.0%, isononyl isononanoate 2.0%~3.0%, glycerol
5.0%~8.0%, Sodium Hyaluronate 0.02%~0.05%, thickener 0.08%~0.3%, octyl butanedioic acid aluminium starch
2.0%~3.0%, propylene glycol 3.0%~5.0%, anti-sensitizer 0.1%~0.3%, Biopol β 2.0%~3.0%, glucan
2.0%~3.0%, hazel extract 1.0%~3.0%, surplus are deionized water.
4. the composition according to claim 1 or 2 with oil-control bacteriostasis efficacy, which is characterized in that it includes such as that it, which is formulated,
The each component of lower mass percent: PEG-20 methyl sesquistearate 1.0%~3.0%, isooctadecanol isostearic acid
Ester 1.0%~5.0%, methyl sesquistearate 1.2%~2.0%, isononyl isononanoate 2.0%~6.0%, glycerol
2.0%~5.0%, Sodium Hyaluronate 0.05%~0.10%, thickener 0.1%~0.3%, octyl butanedioic acid aluminium starch
0.5%~3.0%, propylene glycol 0.8%~5.0%, anti-sensitizer 0.2%~0.3%, Biopol β 2.0%~5.0%, glucan
1.0%~3.0%, hazel extract 3.0%~5.0%, surplus are deionized water.
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| CN106580734A (en) * | 2017-03-08 | 2017-04-26 | 张仕英 | Formula and preparation process of cleansing milk containing porous PMMA particles |
| CN107582490A (en) * | 2017-10-10 | 2018-01-16 | 胡江宇 | A kind of hand lotion containing ginger composition |
| CN111568801A (en) * | 2020-05-07 | 2020-08-25 | 广州蛋壳网络科技有限公司 | Polysaccharide-containing moisturizing and oil-controlling composition and application thereof in cosmetics |
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