CN102188346A - Formula with whitening and anti-aging effects and application thereof - Google Patents
Formula with whitening and anti-aging effects and application thereof Download PDFInfo
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- CN102188346A CN102188346A CN2011101041965A CN201110104196A CN102188346A CN 102188346 A CN102188346 A CN 102188346A CN 2011101041965 A CN2011101041965 A CN 2011101041965A CN 201110104196 A CN201110104196 A CN 201110104196A CN 102188346 A CN102188346 A CN 102188346A
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Abstract
The invention provides a compound formula with whitening and anti-aging effects and application thereof. The formula is formed by compounding plant extract, vitamin and biochemical preparation. The plant extract consists of one or more of herbal plants of pine extract, vitamin A, vitamin E, rhodiola rosea extract, lily extract, dipotassium glycyrrhizate, hyaluronic acid, azelaic acid, propolis, grape seed, seaweed, phytic acid, green tea, sea-buckthorn, usnic acid, abietic acid, vitamin C, vitamin B, vitamin E, maltose, maltitol, glucose, glucitol, glucan, trehalose, glycyrrhizinic acid and the like; and proved by a large amount of clinical tests, the formula has good whitening and anti-aging effects on the skin. The formula can be prepared into cosmetics such as cleaning products, maintenance products, beautifying products and the like according to the conventional processes and accessories for preparing the cosmetics.
Description
Technical field
The invention belongs to the Chinese medicine technical field, relate to a kind of prescription prescription and preparation of whitening anti-aging, also relate to the application in these prescription cosmetics simultaneously.
Background technology
The whitening anti-aging cosmetics are the focuses that society chases always.But the whitening anti-aging cosmetics of society always do not reach everybody requirement at present.If it were not for DeGrain, if it were not for being exactly contains the heavy metal that exceeds standard, if it were not for just having very strong zest.Our company excavates Chinese ancient prescription from Chinese medicine, uses modern advanced technologies, adds necessary vitamin and the biochemical preparation of human body, strengthens the whitening anti-aging effect, and greatly reduces zest.
Summary of the invention
The object of the present invention is to provide a kind of prescription of whitening anti-aging.
Another object of the present invention provides the application of this prescription in the preparation cosmetics.
Prescription of the present invention, select for use pine extract, vitamin A, vitamin E, Radix Rhodiolae extract, Bulbus Lilii extract, dipotaccium glycyrrhizate, hyaluronic acid and azelaic acid to make up, these raw material combination make each efficacy of drugs produce synergism, thus skin played whiten, antidotal effect.
Extract from pine needles is a kind of Natural antioxidant of high effect nontoxic, the Natural antioxidant and nutrients such as its rich in vitamin E, vitamin C, vitamin D, beta-carotene, sterol, trace element, growth hormone and flavone compound oligomeric proanthocyanidin have the effect of nourishing beauty and disease preventing and treating to human body skin.Can go down cutaneous pigmentation, soften cuticle suppress the skin secretion, keep lubricated, delicate, fine and smooth, the softish naturally effect of skin.Clinical showing, Folium Pini and series of products all have significant curative effect to treatment chilblain, dermatitis, eczema, acne, and effectively sick to alopecia areata, chronic ulcer, comedo etc.
Vitamin A is a kind of regulator of normalization, and it is not only normal development, also is the growth of fingernail and hair and safeguards necessary.Its major function is the normal condition that keeps various skin surfaces, helps to keep skin soft and plentiful, improves the function of skin as the barrier layer of water.It has the effect of tangible anti-angle proteinization, and can delaying decrepitude of skin, and is very effective to the acne topical therapeutic, also can prevent pachylosis, chilblain, Exposure to Sunlight, tanned, dandruff and erosion etc.
Vitamin E is the injury of the fatty acid oxidation thing that causes because of cells injury or enzyme deactivation of a kind of antioxidant and preventing.A large amount of experiment confirms, vitamin E have the photo-aging of delaying, sun-proof, suppress sunburn, level and smooth skin, reduce wrinkle of skin, effects such as skin moistening and antiinflammatory.Apparent in view prevent pachylosis, chap, macule, little wrinkle, black speck, macula lutea, freckle, acne, Exposure to Sunlight, dandruff and antiinflammatory etc.
Radix Rhodiolae extract belongs to herbaceos perennial, and it has medical value in the 107 kinds of sengreens in the world, be famous and precious medicinal plants; China mainly is grown in height above sea level more than 3500 meters among the high mountain.Main component is rhodioloside and butyl alcohol, and polyphenol is arranged in addition, protein, fat, tannic acid, flavone compound and trace element volatile oil, and trace element such as ferrum, zinc, stannum, molybdenum, manganese.Scientific research proves: Radix Rhodiolae all is better than Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi at aspects such as anti-hypoxia, resisting fatigue, defying age, adjusting human immunities.
Dipotaccium glycyrrhizate comes from Radix Glycyrrhizae extract, is a kind of biochemical preparation, can make that skin is fine and smooth to be moistened, and keeps smooth, tender, have preserve moisture, antiinflammatory, antipruritic and Bearberry Extract.Share with other component, can strengthen other active matters sun-proof, brighten, the curative effect of aspect such as conditioning and anti-acne.
Hyaluronic acid is a kind of biochemical preparation, can keep skin and hair moisture, and skin care, hair increase gloss, and can prevent the generation of chapped skin and wrinkle.This preparation can obviously reduce the stimulation of environment to skin and hair, reduces the radiation of sunlight to skin and hair.
Azelaic acid comes from Folium Rhododendri Simsii, is a kind of biochemical preparation, has very outstanding sterilization and antibacterial effect, and can strengthen the skin absorbs function, has tangible bright skin and white-skinned face function.
We reach collaborative effect with the one or more combination in these raw materials.
Through a large amount of test with grope, the consumption of drug component of the present invention has effect preferably in following portions by weight:
Prescription: by weight percentage
Pine extract 0.1～60%, vitamin A 0.5～50%, vitamin E 0.8～35%, Radix Rhodiolae extract 0.6～28%, Bulbus Lilii extract 1～55%, dipotaccium glycyrrhizate 0.01～50%, hyaluronic acid 0.001～5%, azelaic acid 0.1～50.
The preferred proportion of prescription exists:
Pine extract 0.5～3%, vitamin A 0.8～35%, vitamin e1～31%, Radix Rhodiolae extract 0.8～25%, Bulbus Lilii extract 2～30%, dipotaccium glycyrrhizate 0.1～30%, hyaluronic acid 0.01～4%, azelaic acid 0.5～35.
The optimum material proportion of prescription is:
Pine extract 1～25%, retinol1～25%, vitamin e1～25%, Radix Rhodiolae extract 1～15%, Bulbus Lilii extract 5～30%, dipotaccium glycyrrhizate 0.1～20%, hyaluronic acid 0.01～2%, azelaic acid 0.5～20.
In order to make the whitening of prescription of the present invention, defying age effect more outstanding, in above-mentioned prescription, can comprise Mel, propolis, Semen Vitis viniferae, Sargassum, phytic acid, green tea, Fructus Hippophae, usnic acid, rosin acid, vitamin C, vitamin B, vitamin D, maltose, maltose alcohol, glucose, glucitol, glucosan, trehalose, glycyrrhizic acid can be selected wherein one or more for use.Since the astriction of Mel, the non-oxidizability of propolis, Semen Vitis viniferae good wetting property, the antibiotic property of phytic acid, the nutrition of Sargassum, green tea slow down wrinkle, whitening of Fructus Hippophae, the defying age of usnic acid, rosin acid antibiotic, the easy infiltration of maltose alcohol, the sandworm of VD, VB preserves moisture, the free radical resisting of VC, the multi-nutrition of glucosan, the sterilization of trehalose, the glycyrrhizic acid sterilization utilizes the composite of these Chinese herbal medicine and raw material noted earlier, reaches best whitening anti-aging effect.The percentage by weight of these compositions is 0.1～25%, and preferred proportion is 0.1～18%, and optimal proportion is 1～15%.
The hybrid technique of prescription of the present invention:
With above-mentioned prescription mix homogeneously, add permeation-promoter and get final product.
Permeation-promoter in the extraction process is to be mixed by following component in percentage by weight:
Organic solvent or water 0.01～90%, surfactant 0～55%, co-penetrant 0～50%.
Wherein organic solvent can be an alcohols: as ethanol, and ethylene glycol, Polyethylene Glycol, propylene glycol, poly-propanol, glycerol, polyglycereol, 1,3 butanediol etc., ethanol preferably, polypropylene glycol, 1,3 butanediol;
Also can select liquid grease for use: as the acetone ester, ether ester, ethyl acetate, preferably ethyl acetate;
Also can be oil: as white oil, Oleum Hippophae, Semen Lini oil, American Avocado Tree oil, Flos Camelliae Japonicae caul-fat, safflower oil, almond oil, Oleum Caryophylli, azalea oil, Camellia oil, azalea oil preferably, Oleum Caryophylli, safflower oil;
Above-mentioned surfactant can be:
Anion surfactant: as metal carboxylate, general formula is RCOOM, M representation metal ion wherein, and R is the alkyl that contains 11～17 carbon atoms; Sulfonates; The sulfuric ester salt;
Above-mentioned cationic surfactant: as the amine salt class; Quaternary ammonium salt; Pyridine salt etc.;
Non-ionic surface active agent: as Polyethylene Glycol (PEG) or polyoxyethylene (POE) type; Polyhydric alcohol type and high molecular surfactant etc.;
Amphoteric surfactant: as betaines; Amino acids; Imidazolines etc.
Above-mentioned co-penetrant can be inorganic salt such as sodium chloride, potassium chloride, zinc sulfate, sodium sulfate etc., also can be quintessence oil, as Flos Rosae Rugosae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, Radix Et Rhizoma Nardostachyos quintessence oil, Flos pini quintessence oil, Japan pepper essential oil etc.
Prescription of the present invention can be prepared into cleaning class, skin type and beautify cosmetics such as class according to the common process and the adjuvant of preparation cosmetics
The specific embodiment
Illustrate that below by specific embodiment the present invention hides the preparation and the whitening anti-aging effect thereof of herbal extracting solution.
Embodiment 1～8 is the preparation prescription of prescription of the present invention, specifically sees Table 1, and unit by weight percentage.
The preparation of the prescription of table 1 embodiment 1～8 prescription
| Title | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | Example 7 | Example 8 |
| Pine extract | 25 | ?24 | ?23 | ?22 | ?10 | ?15 | ?60 | ?1 |
| Vitamin A | 1 | ?50 | ?15 | ?10 | ?20 | ?25 | ?22 | ?25 |
| Vitamin E | 1 | ?25 | ?20 | ?10 | ?9 | ?16 | ?2 | ?22 |
| Radix Rhodiolae extract | 15 | ?10 | ?2 | ?1 | ?15 | ?10 | ?2 | ?1 |
| Bulbus Lilii extract | 28 | ?0.6 | ?10 | ?20 | ?28 | ?0.6 | ?10 | ?20 |
| Dipotaccium glycyrrhizate | 0.01 | ?20 | ?50 | ?20 | ?10 | ?20 | ?50 | ?20 |
| Hyaluronic acid | 0.001 | ?2 | ?3 | ?2 | ?5 | ?1 | ?0.8 | ?2 |
| Azelaic acid | 50 | ?15 | ?30 | ?10 | ?10 | ?0.1 | ?30 | ?10 |
| Mel | 5 | ?10 | ?15 | ?5 | ?5 | ?10 | ?15 | ?10 |
| Sargassum | 5 | ?15 | ?20 | ?5 | ?5 | ?15 | ?20 | ?15 |
| Phytic acid | 8 | ?8 | ?15 | ?8 | ?8 | ?8 | ?15 | ?8 |
| Green tea | 10 | ?20 | ?30 | ?10 | ?10 | ?20 | ?30 | ?20 |
| Fructus Hippophae | 10 | ?10 | ?10 | ?10 | ||||
| Glucosan | 10 | ?1 |
| Vitamin C | 10 | ?5 | ||||||
| Usnic acid | ?10 | ?10 | ||||||
| Rosin acid | ?10 | ?10 | ||||||
| Ethanol | 500 | |||||||
| Water | 500 | ?500 | ?500 | ?500 | ?500 | ?500 | ?500 | ?500 |
| Propylene glycol | ?500 | |||||||
| Ethyl acetate | ?500 | |||||||
| Ether | ?500 | |||||||
| White oil | ?500 | |||||||
| Ethanol+ether=1: 1 | ?500 | |||||||
| Rose oil | 2 | ?2 | ?2 | ?2 | ||||
| Peregal-4 | 5 | ?5 | ?5 | ?5 | ?5 | ?5 | ?5 | ?5 |
| Polysorbas20 | ?3 | ?2 | ?2 | ?2 |
Preparation method: with book on Chinese herbal medicine mix homogeneously proportionally, add permeation-promoter, mix homogeneously gets final product.
The whitening anti-aging measure of merit of embodiment 1～8 gained extracting solution:
Embodiment 9
Get embodiment 1～8 each 5g of gained extracting solution respectively, and be diluted to 50g with glycerol respectively, it is standby to be prepared into the facial film skin-protection product;
Healthy normal trial volunteer 80 people of choosing are divided into 8 groups, every group 10 people, and, make this part, zone tanned with UVA irradiation wrist medial region;
Smear for respectively 8 groups of experimenters with the diluent of embodiment 1～8 extracting solution, one day 2 times, smeared 30 days, only smear half of skin tanning at every turn.
Testing result: after 30 days, every group of experimenter be local to shine black region to smear half of extracting solution diluent all original whiter without tanned skin, and shine that black region do not smear the extracting solution diluent half significantly deceived without tanned skin originally.
Result of the test shows that prescription of the present invention has good whitening effect to people's skin.
Embodiment 10
Get embodiment 1～8 each 5g of gained extracting solution respectively, and be diluted to 50g with glycerol respectively, preparation cleansing milk cleaning product is standby;
Selecting freckle, patient with chloasma 80 people is the experimenter, is divided into 8 groups, every group 10 people;
Smear the position that face has freckle, chloasma for respectively 8 groups of experimenters with the diluent of embodiment 1～8 extracting solution, one day 2 times, smeared 30 days;
Testing result: the freckle of 80 experimenter's faces, chloasma all have desalination in various degree.
Implementation column 11
Get embodiment 1～8 each 5g of gained extracting solution respectively, and be diluted to 50g with glycerol respectively, being prepared into foundation emulsion, to beautify product standby;
Healthy normal trial volunteer 80 people of choosing are divided into 8 groups, every group 10 people;
Smear face for respectively 8 groups of experimenters with the diluent of embodiment 1～8 extracting solution, one day 2 times, smeared 30 days;
Testing result: skin exquisiteness, glossy before 80 experimenters smear, good springiness.
Claims (9)
1. antidotal prescription of Pear Power is to be formed by following raw material and prepared:
Prescription: by weight percentage
Pine extract 1～25%, retinol1～25%, vitamin e1～25%, Radix Rhodiolae extract 1～15%, Bulbus Lilii extract 5～30%, dipotaccium glycyrrhizate 0.1～20%, hyaluronic acid 0.01～2%, azelaic acid 0.5～20%
Technology:
With above-mentioned raw materials and permeation-promoter mix homogeneously promptly.
2. the antidotal prescription of Pear Power as claimed in claim 1 is characterized in that: also comprise 0.5～15% in the described prescription, Mel, propolis, Semen Vitis viniferae, Sargassum, phytic acid, green tea, Fructus Hippophae, usnic acid, rosin acid, vitamin C, vitamin B, vitamin E, maltose, maltose alcohol, glucose, glucitol, glucosan, trehalose, at least a in the glycyrrhizic acid.
3. the antidotal prescription of Pear Power as claimed in claim 1, it is characterized in that: the permeation-promoter in the described extraction process is to be mixed by following percentage by weight composition: organic solvent or water 0.01～90%, surfactant 0～55%, co-penetrant 0～50%.
4. the antidotal prescription of Pear Power as claimed in claim 3 is characterized in that: described organic solvent is any in alcohols, ethers, ketone, liquid grease, vegetable oil, mineral oils or the aromatic compound.
5. the antidotal prescription of Pear Power as claimed in claim 3 is characterized in that: described surfactant is anion surfactant or cationic surfactant or amphoteric surfactant or non-anion surfactant.
6. the antidotal prescription of Pear Power as claimed in claim 3 is characterized in that: described co-penetrant is inorganic salt and quintessence oil.
7. the antidotal prescription of Pear Power as claimed in claim 1, conventional formulation, technology and adjuvant by the preparation cleaning product are prepared into cleaning product.
8. the antidotal prescription of Pear Power as claimed in claim 1, conventional formulation, technology and adjuvant by preparation maintenance product are prepared into the maintenance product.
9. the antidotal prescription of Pear Power as claimed in claim 1 beautifies conventional formulation, technology and the adjuvant of product with preparation, is prepared into and beautifies product.
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| CN2011101041965A CN102188346A (en) | 2011-04-26 | 2011-04-26 | Formula with whitening and anti-aging effects and application thereof |
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| CN2011101041965A CN102188346A (en) | 2011-04-26 | 2011-04-26 | Formula with whitening and anti-aging effects and application thereof |
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| CN103462866A (en) * | 2013-09-01 | 2013-12-25 | 梁苑春 | All natural termite powder neck mask cream |
| KR20140034595A (en) * | 2012-09-12 | 2014-03-20 | (주)아모레퍼시픽 | Compositions containing a dehydroabietic acid for skin whitening |
| CN104997669A (en) * | 2014-12-26 | 2015-10-28 | 尚臣美邦（北京）生物科技有限公司 | Composition for cleansing face, tendering skin and improving skin metabolism |
| CN105287261A (en) * | 2015-10-28 | 2016-02-03 | 广州靓美莲美容科技有限公司 | Azelaic acid compound acne removal cream containing rose oil and preparation method of cream |
| CN105769602A (en) * | 2016-04-21 | 2016-07-20 | 黄艳敏 | Safe and multivitamin compounded freckle-removing cream and preparation method thereof |
| CN106265106A (en) * | 2016-08-24 | 2017-01-04 | 华泽庆 | A kind of cleansing milk adding kieselguhr and extract from pine needles and preparation method thereof |
| CN106723521A (en) * | 2017-03-14 | 2017-05-31 | 石桐瑄 | A kind of haze composition, agalloch eaglewood haze mouth mask and its preparation technology |
| CN106860182A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN106860139A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN106860079A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN107744487A (en) * | 2017-11-30 | 2018-03-02 | 林俊浩 | One kind improves the obscure composition of the colour of skin |
| CN108524333A (en) * | 2018-05-04 | 2018-09-14 | 江苏欧亚立日化有限公司 | A kind of efficient moisturizing skin cream of eutrophy and preparation method thereof |
| CN109689020A (en) * | 2016-09-08 | 2019-04-26 | 株式会社爱茉莉太平洋 | For skin anti-aging, composition comprising dehydroabietic acid and compound K |
| WO2023128946A1 (en) * | 2021-12-27 | 2023-07-06 | Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi | Skin cleansing product |
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2011
- 2011-04-26 CN CN2011101041965A patent/CN102188346A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20140034595A (en) * | 2012-09-12 | 2014-03-20 | (주)아모레퍼시픽 | Compositions containing a dehydroabietic acid for skin whitening |
| KR101970504B1 (en) | 2012-09-12 | 2019-04-19 | (주)아모레퍼시픽 | Compositions containing a dehydroabietic acid for skin whitening |
| CN103462866A (en) * | 2013-09-01 | 2013-12-25 | 梁苑春 | All natural termite powder neck mask cream |
| CN104997669A (en) * | 2014-12-26 | 2015-10-28 | 尚臣美邦（北京）生物科技有限公司 | Composition for cleansing face, tendering skin and improving skin metabolism |
| CN105287261B (en) * | 2015-10-28 | 2017-11-17 | 广州靓美莲美容科技有限公司 | A kind of azalaic acid compound acne-removing cream containing rose oil and preparation method thereof |
| CN105287261A (en) * | 2015-10-28 | 2016-02-03 | 广州靓美莲美容科技有限公司 | Azelaic acid compound acne removal cream containing rose oil and preparation method of cream |
| CN105769602A (en) * | 2016-04-21 | 2016-07-20 | 黄艳敏 | Safe and multivitamin compounded freckle-removing cream and preparation method thereof |
| CN106265106A (en) * | 2016-08-24 | 2017-01-04 | 华泽庆 | A kind of cleansing milk adding kieselguhr and extract from pine needles and preparation method thereof |
| CN109689020B (en) * | 2016-09-08 | 2022-06-21 | 株式会社爱茉莉太平洋 | Composition containing dehydroabietic acid and compound K for resisting skin aging |
| CN109689020A (en) * | 2016-09-08 | 2019-04-26 | 株式会社爱茉莉太平洋 | For skin anti-aging, composition comprising dehydroabietic acid and compound K |
| CN106860139A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN106860079A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN106860182A (en) * | 2017-01-19 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-aging emulsion |
| CN106723521A (en) * | 2017-03-14 | 2017-05-31 | 石桐瑄 | A kind of haze composition, agalloch eaglewood haze mouth mask and its preparation technology |
| CN107744487A (en) * | 2017-11-30 | 2018-03-02 | 林俊浩 | One kind improves the obscure composition of the colour of skin |
| CN108524333A (en) * | 2018-05-04 | 2018-09-14 | 江苏欧亚立日化有限公司 | A kind of efficient moisturizing skin cream of eutrophy and preparation method thereof |
| WO2023128946A1 (en) * | 2021-12-27 | 2023-07-06 | Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi | Skin cleansing product |
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Application publication date: 20110921 |