CN108524414A - A kind of more effect Chinese pitted skin films and its preparation process - Google Patents
A kind of more effect Chinese pitted skin films and its preparation process Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses a kind of facial mask composition and its preparation processes, are formulated by a certain percentage by the cannabidiol of given activity component content, propolis extract, ginseng extract, ginseng essential oil, collagen, Gotu Kola P.E, Rosmarinic acid and water, moisturizer, thickener, preservative, solubilizer.By rationally utilizing the anti-inflammatory anti-allergic effects of cannabidiol, the skin repair of propolis extract to act on, in ginseng extract, the cytotrophy of saponin(e and ginseng essential oil is acted on antibacterial action, the skin-tightening effect of Gotu Kola P.E, the water conservation wetting action of collagen and the Eradicates spots of Rosmarinic acid, is made mask product provided by the present invention with moisturizing, whitening, is removed the multi-efficiencies such as wrinkle, anti-inflammatory, antiultraviolet, nti-freckle.Simultaneously because active component content is clear, consequently facilitating ensureing product quality.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of more effect Chinese pitted skin films and its preparation process.
Background technology
Facial mask is important face skin nursing product, and nursing purpose includes moisturizing, whitening, cytotrophy, anti-inflammatory, anti-purple
Outside line, anti-oxidant, nti-freckle etc..Common facial mask is often relatively simple due to ingredient and the difference of content, nursing role, it is difficult to reach
Multiple demand of the consumer to skin nursing；Or because different batches raw material due to active component content difference it is excessive, cause to produce
Product effect is unstable.
A large amount of data with practice have shown that, cannabidiol, propolis extract, ginsenoside, ginseng essential oil, collagen egg
In vain, Gotu Kola P.E, Rosmarinic acid all have good nursing role to skin, can be used for the preparation of facial mask essence.
Cannabidiol (CBD) is to come from the annual grass of Cannabaceae (Cannabinaceae) Cannabis Cannabis Linn.
A kind of active skull cap components in this cannabis plant Cannabis sativa Linn. stems, leaf, seed have anti-oxidant, anti-ageing
A variety of pharmacological activity such as always, anti-inflammatory, antibacterial, antiallergy, uvioresistant, before medicine, cosmetic field have a wide range of applications
Scape.
Propolis is a kind of extremely rare natural resources, is known as the title of " purple gold ", includes 20 major class more than totally 300 kind battalion
It forms point, such as flavones, terpene, organic acid, vitamin and various trace elements.It can not only eliminate fungal infection, additionally it is possible to
It decomposes pigment, calm down wrinkle, delaying senility, accelerate the healing of histiocytic regeneration and wound, to the left acne scar of small pox
Acne print also has good curative effect.
Ginseng is known as " King of Herbs ", and various effects are confirmed by a large amount of Research Literature and practice.
For skin, ginseng because containing the active skull cap components such as ginsenoside, Panaxynol (being primarily present in ginseng essential oil),
It can promote blood circulation, prevent skin ageing and wrinkle from generating, increase the nutrition supply of skin, play tonifying Qi beauty treatment and promoting blood circulation
Effect, while immune function can also be improved, prevent skin from receiving the destructive stimulus of external environment；Can accelerate human metabolism,
Deep layer moisturizing prevents dry and aging, and effectively treats the effect of itch and decortication, keeps face skin moist.People
Ginseng saponin(e is mostly produced with solvent extraction, column chromatography purifying etc., and ginseng essential oil is then with supercritical carbon dioxide extraction
It is preferred.
Centella is commonly called as plant collagen.Epidermis and corium interconnecting piece the study found that Gotu Kola P.E can compact
Point, skin can be made to limber up, help to solve cutis laxa phenomenon, keep skin smooth flexible；Help promotes glue in skin corium
Former albumen is formed, and fibrin is made to regenerate, and reconnect is got up, make skin achieve the effect that compact it is smooth；It can help impaired
Organization healing and consolidation skin can promote the close connection between epidermis and corium and inhibit the increase of adipocyte, prevent
Only hydroderma, appearance are fat.In addition, Gotu Kola P.E also has anti-oxidant, inhibition free radical activity, adjusting skin immune
Power, desalination melanin pigmentation, the regeneration of update skin cell, increase skin water conservation degree, activation update skin cell, antiallergic protection are made
With so as to protect skin from external injury.
Collagen is the main component in animal connective tissue, and content is most in the mammalian body, distribution is most wide
Functional protein, account for the 25%~30% of total protein, certain organisms are even as high as 80% or more.The skin of collagen
Skin nursing is mainly due to its powerful latching moisture of unique triple-helix structure energy, the shape for allowing the skin moment to keep moistening, water tender
State is natural moisturizing factor.It is strong to the permeability of skin additionally, due to collagen, it can pass through cuticula and skin epithelial cell
In conjunction with, the metabolism of Skin Cell is participated in and improved, the collagen activity in skin is made to reinforce, holding cuticula moisture and fiber
The integrality of structure improves Skin Cell living environment and promotes the metabolism of skin histology, enhances blood circulation, reach taste
Moisten the purpose of skin.
Rosmarinic acid (Rosmarinicacid, abbreviation RosA) is a kind of natural phenolic acid constituents, is widely present in fan and changes
In the plants such as perfume, Prunella vulgaris, Salvia japonica.Rosmarinic acid has extremely strong removing interior free yl activity and antioxidant activity, has
Help cell damage caused by preventing free radical, and pigment deposition can be eliminated by improving microcirculation, achievees the effect that Eradicates spots.
In addition Rosmarinic acid also has broad-spectrum anti-microbial activity, has inhibiting effect to bacterium and fungi, and can inhibit by micro- allergy
The allergic inflammation of original induction, is alternatively arranged as a kind of bright protective agent, plays the role of radiation protection antiultraviolet.Currently, rosemary
Acid has embodied its important application value in the fields such as pharmacy, food, cosmetics.
Above-mentioned cannabidiol, propolis extract, ginsenoside, ginseng essential oil, collagen, Gotu Kola P.E, fan change
Fragrant acid all has a good nursing role to skin, nursing efficacy be presented as respectively it is anti-inflammatory with antiultraviolet, cytotrophy with
Skin repair moisturizes the skin, goes wrinkle, Eradicates classes of whitening etc..By rationally controlling the ratio of each ingredient, it can assign facial mask multiple work(
Effect, to meet multiple demand of the consumer to skin nursing.Differ additionally, due to active component content in extract, causes to produce
Product stable effect is poor, it is therefore necessary to is defined to the content of active constituent in raw material.
Invention content
The present invention be directed to consumers to the moisturizing of skin nursing, whitening, go wrinkle, anti-inflammatory, antiultraviolet, nti-freckle etc. multiple
Demand provides a kind of more effect facial masks and its preparation process.
The present invention is achieved by the following technical solutions：
A kind of more effect Chinese pitted skin films, are composed of the following raw materials in parts by weight：100 parts of water, 5~10 parts of moisturizer, 5~10
Part thickener, 0.1~1 portion of preservative, 5~10 parts of solubilizer, 0.5~1 part of cannabidiol, 1~10 part of propolis extract, 0.5
~5 parts of ginseng extract, 0.05~1 part of ginseng essential oil, 1~5 part of collagen, 1~5 part of Gotu Kola P.E, 0.5~1
Part Rosmarinic acid.
The cannabinol purity is not less than 95%.
General flavone content is not less than 50% in the propolis.
Total saponin content is not less than 75% in the ginseng extract.
The ginseng essential oil is the essential oil extracted from ginseng with supercritical carbon dioxide.
The Gotu Kola P.E uses (20~100)：1 ratio extract.
The collagen purity is not less than 90%.
The Rosmarinic acid purity is not less than 95%.
The moisturizer is one or more mixing in glycerine, propylene glycol, butanediol, sorbierite, hyaluronic acid
Object.
The thickener is one or more mixtures in xanthans, sodium carboxymethylcellulose, chitosan.
The preservative is the mixture of one or both of Phenoxyethanol, methylisothiazolinone.
The solubilizer is Cremophor RH40.
The method for preparing more effect Chinese pitted skin films using above-mentioned composition, which is characterized in that include the following steps：
1. take the water of half formula ratio, 50 DEG C~80 DEG C pre-temperatures, sequentially add solubilizer, cannabidiol, propolis extract,
Ginsenoside, ginseng essential oil fully dissolve and stir evenly postcooling to room temperature.
2. separately taking the water of half formula ratio, 30 DEG C~50 DEG C pre-temperatures sequentially add moisturizer, thickener, preservative, collagen
Albumen, Gotu Kola P.E, Rosmarinic acid fully dissolve and stir evenly postcooling to room temperature.
3. mixing two kinds of solution, stir, detect sense organ physical and chemical index, after qualified it is filling to obtain the final product.
By adopting the above-described technical solution, the present invention has the advantages that：
1. making in the skin repair of the upper anti-inflammatory anti-allergic effects for rationally utilizing cannabidiol of formula design, propolis extract
With the cytotrophy of, ginsenoside and ginseng essential oil and antibacterial action, the skin-tightening effect of Gotu Kola P.E, collagen
Water conservation wetting action and Rosmarinic acid Eradicates spots effect, make product have multiple nursing effect.
2. carrying out specific active component content restriction to raw material, it is more advantageous to and product progress quality control and effect is commented
Valence.
It is inclined to by thermally labile 3. collagen, Rosmarinic acid all have, therefore at relatively low temperature by the two
With being mixed again with other feed liquids after liquid, to keep the stability of both ingredients in process of production.
Specific implementation mode
The following examples are not the limitation to substantive content of the present invention to explain the present invention.For not special
Dated technological parameter or condition can refer to routine techniques progress.
A kind of more effect Chinese pitted skin films of embodiment 1. and its preparation process
100 parts of water, 5 parts of propylene glycol, 5 parts of xanthans, 0.1 part of methylisothiazolinone, 5 parts of PEG-40 hydrogen are weighed by weight
Change castor oil, 0.5 part of cannabidiol (purity 96%, HPLC), 1 part of propolis extract (general flavone content 67%, UV), 0.5 part
Ginseng extract (total saponin content 82%, UV), 0.05 part of ginseng essential oil (supercritical carbon dioxide extraction), 1 part of glue
Former albumen (purity 96%), 5 parts of Gotu Kola P.Es (30：1 ratio extract), 0.5 part of Rosmarinic acid (purity 97%,
HPLC)。
The water of half formula ratio, 50 DEG C~80 DEG C pre-temperatures is taken to sequentially add Cremophor RH40, cannabidiol, bee
Glue extract, ginsenoside, ginseng essential oil fully dissolve and stir evenly postcooling to room temperature；The another water for taking half formula ratio,
30 DEG C~50 DEG C pre-temperatures, sequentially add propylene glycol, xanthans, methylisothiazolinone, collagen, Gotu Kola P.E, fan
Repeatedly fragrant acid, fully dissolves and stirs evenly postcooling to room temperature.Two kinds of solution are mixed, are stirred, sense organ physics and chemistry is detected
Index, after qualified it is filling to obtain the final product.
A kind of more effect Chinese pitted skin films of embodiment 2. and its preparation process
100 parts of water, 10 parts of butanediols, 10 parts of sodium carboxymethylcelluloses, 1 part of Phenoxyethanol, 10 parts of PEG- are weighed by weight
40 rilanit specials, 1 part of cannabidiol (purity 95%, HPLC), 10 parts of propolis extracts (general flavone content 72%, UV), 5 parts
Ginseng extract (total saponin content 77%, UV), 1 part of ginseng essential oil (supercritical carbon dioxide extraction), 5 portions of collagen eggs
(purity 98%) in vain, 2 parts of Gotu Kola P.Es (50：1 ratio extract), 1 part of Rosmarinic acid (purity 98%, HPLC).
The water of half formula ratio, 50 DEG C~80 DEG C pre-temperatures is taken to sequentially add Cremophor RH40, cannabidiol, bee
Glue extract, ginsenoside, ginseng essential oil fully dissolve and stir evenly postcooling to room temperature；The another water for taking half formula ratio,
30 DEG C~50 DEG C pre-temperatures, sequentially add butanediol, sodium carboxymethylcellulose, Phenoxyethanol, collagen, Gotu Kola P.E,
Rosmarinic acid fully dissolves and stirs evenly postcooling to room temperature.Two kinds of solution are mixed, are stirred, detection sense organ reason
Change index, after qualified it is filling to obtain the final product.
A kind of more effect Chinese pitted skin films of embodiment 3. and its preparation process
100 parts of water, 8 parts of hyaluronic acids, 5 parts of sodium carboxymethylcelluloses, 0.1 part of Phenoxyethanol, 0.1 part of first are weighed by weight
Base isothiazolinone, 6 parts of Cremophor RH40s, 0.6 part of cannabidiol (purity 97%, HPLC), 4 parts of propolis extracts
(general flavone content 87%, UV), 1 part of ginseng extract (total saponin content 82%, UV), 0.1 part of ginseng essential oil (overcritical two
Carbon oxide fluid extracts), 2 parts of collagens (purity 98%), 1 part of Gotu Kola P.E (100：1 ratio extract), 1 part of fan
Repeatedly fragrant sour (purity 97%, HPLC).
The water of half formula ratio, 50 DEG C~80 DEG C pre-temperatures is taken to sequentially add Cremophor RH40, cannabidiol, bee
Glue extract, ginsenoside, ginseng essential oil fully dissolve and stir evenly postcooling to room temperature；The another water for taking half formula ratio,
30 DEG C~50 DEG C pre-temperatures, sequentially add butanediol, sodium carboxymethylcellulose, Phenoxyethanol, collagen, Gotu Kola P.E,
Rosmarinic acid fully dissolves and stirs evenly postcooling to room temperature.Two kinds of solution are mixed, are stirred, detection sense organ reason
Change index, after qualified it is filling to obtain the final product.
4. sense organ of embodiment and physicochemical property evaluation
1 made facial mask liquid of Example is placed 15 days at 40 DEG C and 0 DEG C respectively, carries out sense organ and physicochemical property test, knot
Fruit is shown in Table 1. as it can be seen from table 1 facial mask liquid appearance is clarified, is transparent, and weakly acidic, stability is good, mildly, to facial nothing after applying
Stimulation.With rear skin comfort, salubrious, moistening is good；After a period of use, it can be clearly felt that skin has the effect to bleach,
And skin becomes to compact, and wrinkle significantly reduces.
1. sense organ of table and physical and chemical index testing result
The investigation on probation of 5. facial mask of embodiment
2 made facial mask of Example carries out investigation on probation.Altogether provide 20 parts of questionnaire, evaluation index include comfort level,
Moisten degree, salubrious sense, whitening effect, remove wrinkle, Eradicates spots etc., using arithmetic average Data-Statistics, final appraisal results are shown in Table 2.
As can be seen from Table 2, every score illustrates that the facial mask prepared by the present invention is a more effects at 4 points or more
Facial mask.
2. questionnaire survey statistical result of table
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope of present disclosure, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of more effect Chinese pitted skin films, are composed of the following raw materials in parts by weight：100 parts of water, 5~10 parts of moisturizer, 5~10 parts
Thickener, 0.1~1 portion of preservative, 5~10 parts of solubilizer, 0.5~1 part of cannabidiol, 1~10 part of propolis extract, 0.5~5
The ginseng extract of part, 0.05~1 part of ginseng essential oil, 1~5 part of collagen, 1~5 part of Gotu Kola P.E, 0.5~1 part of fan
Repeatedly fragrant acid.
2. a kind of preparation process of more effect Chinese pitted skin films according to claim 1, which is characterized in that including walking as follows
Suddenly：
1. taking the water of half formula ratio, 50 DEG C~80 DEG C pre-temperatures sequentially add solubilizer, cannabidiol, propolis extract, ginseng
Extract, ginseng essential oil fully dissolve and stir evenly postcooling to room temperature；
2. separately taking the water of half formula ratio, 30 DEG C~50 DEG C pre-temperatures sequentially add moisturizer, thickener, preservative, collagen egg
In vain, Gotu Kola P.E, Rosmarinic acid fully dissolve and stir evenly postcooling to room temperature；
3. mixing two kinds of solution, stir, detect sense organ physical and chemical index, after qualified it is filling to obtain the final product.
3. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that cannabinol purity used is not less than
95%.
4. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that general flavone content is not in propolis used
Less than 50%.
5. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that total saposins in ginseng extract used
Content is not less than 75%.
6. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that ginseng essential oil used is with overcritical
The essential oil that carbon dioxide is extracted from ginseng.
7. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that Gotu Kola P.E used uses
(20~100)：1 ratio extract.
8. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that collagen purity used is not less than
90%.
9. a kind of more effect Chinese pitted skin films according to claim 1, which is characterized in that Rosmarinic acid purity used is not less than
95%.
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| CN109820744A (en) * | 2019-04-02 | 2019-05-31 | 浙江邦良日用品有限公司 | A cleaning makeup removing skin care wet tissue based on CBD oil formula |
| CN109908033A (en) * | 2019-04-02 | 2019-06-21 | 浙江邦良日用品有限公司 | A Baby Care wet tissue based on CBD oil formula |
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| WO2021018936A1 (en) | 2019-07-29 | 2021-02-04 | Echo Pharmaceuticals B.V. | Treatment of inflammatory skin conditions |
| WO2021018934A1 (en) | 2019-07-29 | 2021-02-04 | Echo Pharmaceuticals B.V. | Treatment of sebaceous gland disorders |
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